Detailed information for compound 1286890

Basic information

Technical information
  • TDR Targets ID: 1286890
  • Name: N-[2-[(3,4-diethoxyphenyl)amino]-2-oxoethyl]- N-methyl-2-(tetrazol-1-yl)benzamide
  • MW: 424.453 | Formula: C21H24N6O4
  • H donors: 1 H acceptors: 5 LogP: 2.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1OCC)NC(=O)CN(C(=O)c1ccccc1n1cnnn1)C
  • InChi: 1S/C21H24N6O4/c1-4-30-18-11-10-15(12-19(18)31-5-2)23-20(28)13-26(3)21(29)16-8-6-7-9-17(16)27-14-22-24-25-27/h6-12,14H,4-5,13H2,1-3H3,(H,23,28)
  • InChiKey: HHLFRFPKGFRQFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(3,4-diethoxyphenyl)amino]-2-oxo-ethyl]-N-methyl-2-(tetrazol-1-yl)benzamide
  • N-[2-[(3,4-diethoxyphenyl)amino]-2-oxoethyl]-N-methyl-2-(1-tetrazolyl)benzamide
  • N-[2-[(3,4-diethoxyphenyl)amino]-2-keto-ethyl]-N-methyl-2-(tetrazol-1-yl)benzamide
  • N-[2-[(3,4-diethoxyphenyl)amino]-2-oxo-ethyl]-N-methyl-2-(1,2,3,4-tetrazol-1-yl)benzamide
  • T5443037

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Huntingtin homolog 0.0141 0.0508 0.2653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0061 0.0184 0.3172
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0004
Brugia malayi Heterochromatin protein 1 0.0071 0.0227 0.0542
Brugia malayi Pax transcription factor protein 2 0.0485 0.1912 0.4573
Trichomonas vaginalis esterase, putative 0.0077 0.025 0.1307
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0014 0.0074
Trypanosoma brucei trypanothione reductase 0.0047 0.0128 0.2185
Plasmodium vivax methionine--tRNA ligase, putative 0.0061 0.0184 0.1941
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1308 0.313
Onchocerca volvulus 0.0157 0.0576 0.3007
Brugia malayi Thioredoxin reductase 0.0047 0.0128 0.0304
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0337 0.1308 0.313
Plasmodium vivax glutathione reductase, putative 0.0047 0.0128 0.1337
Leishmania major hypothetical protein, conserved 0.0031 0.0064 0.1065
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0157 0.0576 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.007 0.0166
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0087 0.4646
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.025 0.0597
Echinococcus multilocularis GPCR, family 2 0.0081 0.0266 0.0266
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0266 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1308 0.313
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0146 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0052 0.0269
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0041 0.0105 0.0104
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0246 0.0939 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0518
Brugia malayi hypothetical protein 0.023 0.0872 0.2085
Plasmodium vivax hypothetical protein, conserved 0.0077 0.025 0.2644
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0132 0.0313
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0246 0.0939 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0087 0.0902
Echinococcus multilocularis leucyl tRNA synthetase 0.0023 0.0031 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0078 0.0185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0072
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0132 0.0313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0072
Brugia malayi Ets-domain containing protein 0.0074 0.0239 0.057
Echinococcus multilocularis chromobox protein 1 0.0071 0.0227 0.0226
Leishmania major diacylglycerol acyltransferase, putative 0.0157 0.0576 1
Leishmania major glycerol uptake protein, putative 0.0041 0.0105 0.1782
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0041 0.0105 0.2152
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0146 0.1535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0198 0.0197
Schistosoma mansoni hypothetical protein 0.0081 0.0266 0.0635
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0422 0.2163
Loa Loa (eye worm) hypothetical protein 0.0079 0.0256 0.0611
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0087 0.8269
Chlamydia trachomatis leucine--tRNA ligase 0.0023 0.0031 0.9966
Schistosoma mansoni cpg binding protein 0.0033 0.007 0.0166
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0227 0.1187
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Schistosoma mansoni cpg binding protein 0.0039 0.0094 0.0223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0087 0.1474
Echinococcus granulosus microtubule associated protein 2 0.0731 0.2911 0.6965
Echinococcus granulosus o acyltransferase membrane bound domain 0.0041 0.0105 0.0249
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0266 0.0635
Brugia malayi Hhat protein 0.0041 0.0105 0.0249
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0075 0.1116
Onchocerca volvulus 0.0083 0.0273 0.1426
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0198 0.7886
Loa Loa (eye worm) MBOAT family protein 0.0041 0.0105 0.0249
Echinococcus granulosus o acyltransferase membrane bound domain 0.0041 0.0105 0.0249
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0091 0.0216
Schistosoma mansoni hypothetical protein 0.0859 0.3432 0.8212
Schistosoma mansoni methionine-tRNA synthetase 0.0023 0.0031 0.0072
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0198 0.2085
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.1042 0.4179 1
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.015
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0003 0.0013
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0078 0.0185
Loa Loa (eye worm) zinc finger protein 0.0301 0.1163 0.2782
Brugia malayi Glycosylation related protein 12, isoform 0.0036 0.0081 0.0192
Toxoplasma gondii hypothetical protein 0.0041 0.0105 0.1091
Loa Loa (eye worm) hypothetical protein 0.0105 0.0363 0.0866
Leishmania major glycerol uptake protein, putative 0.0041 0.0105 0.1782
Trypanosoma brucei ISWI complex protein 0.0031 0.0064 0.1065
Brugia malayi Fli-1 protein 0.0226 0.0856 0.2046
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.025 0.1307
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0128 0.0304
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0041 0.0105 0.0249
Loa Loa (eye worm) fli-1 protein 0.0226 0.0856 0.2046
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0061 0.0184 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0091 0.0943
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.1846 0.1846
Schistosoma mansoni hypothetical protein 0.0042 0.0108 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.1674 0.4005
Loa Loa (eye worm) glutathione reductase 0.0047 0.0128 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0235 0.0562
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0151
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0157 0.0576 0.1377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.025 0.1276
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0266 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0337 0.1308 0.313
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.0304
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0239 0.057
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0146 0.1535
Trichomonas vaginalis transmembrane protein nessy, putative 0.0041 0.0105 0.0547
Brugia malayi MBOAT family protein 0.0041 0.0105 0.0249
Loa Loa (eye worm) beta-lactamase 0.0077 0.025 0.0597
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.025 0.1276
Echinococcus granulosus o acyltransferase membrane bound domain 0.0041 0.0105 0.0249
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0091 0.1541
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0041 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0249
Brugia malayi hypothetical protein 0.0296 0.114 0.2727
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0041 0.0105 0.0249
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0035 0.0078 0.0184
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0041 0.0105 0.0104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0337 0.1308 0.1308
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0075 0.0372
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0035 0.0078 0.0804
Echinococcus granulosus cpg binding protein 0.0039 0.0094 0.0223
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.025 0.1307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0198 0.0472
Schistosoma mansoni ap endonuclease 0.0037 0.0087 0.0206
Brugia malayi protein ZK524.3 0.0023 0.0031 0.0072
Plasmodium falciparum methionine--tRNA ligase, putative 0.0023 0.0031 0.0303
Leishmania major hypothetical protein, conserved 0.0077 0.025 0.432
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0146 0.2507
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0087 0.3411
Leishmania major hypothetical protein, conserved 0.0052 0.0146 0.2507
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0105 0.0363 0.0362
Mycobacterium leprae Probable lipase LipE 0.0077 0.025 0.5603
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0041 0.0105 0.0249
Schistosoma mansoni bromodomain containing protein 0.0131 0.0471 0.1126
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0041 0.0105 0.0249
Schistosoma mansoni hypothetical protein 0.0035 0.0078 0.0184
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1042 0.4179 1
Leishmania major diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.023 0.0548
Trypanosoma cruzi GUP1, putative 0.0041 0.0105 0.1782
Toxoplasma gondii methionyl-tRNA synthetase 0.0061 0.0184 0.1941
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.1943 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0266 0.0266
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0007 0.0016
Schistosoma mansoni zinc finger protein 0.0031 0.0064 0.015
Loa Loa (eye worm) inositol-1 0.0038 0.0091 0.0216
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.025 0.0597
Schistosoma mansoni zinc finger protein 0.0041 0.0105 0.0249
Trypanosoma cruzi glycerol uptake protein, putative 0.0041 0.0105 0.1782
Brugia malayi Inositol-1 0.0038 0.0091 0.0216
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0091 0.1541
Schistosoma mansoni hypothetical protein 0.0081 0.0266 0.0635
Loa Loa (eye worm) hypothetical protein 0.023 0.0872 0.2085
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0035 0.0078 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Loa Loa (eye worm) hypothetical protein 0.0175 0.0649 0.1552
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0003 0.0013
Echinococcus multilocularis sterol O acyltransferase 1 0.0041 0.0105 0.0104
Brugia malayi hypothetical protein 0.0108 0.0374 0.0893
Mycobacterium ulcerans hypothetical protein 0.0077 0.025 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0041 0.0105 0.1782
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0035 0.0078 0.0184
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0273 0.0653
Schistosoma mansoni ap endonuclease 0.0037 0.0087 0.0206
Onchocerca volvulus 0.0033 0.007 0.0363
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0112 0.0583
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0091 0.0475
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.025 0.0597
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.025 1
Mycobacterium ulcerans beta-lactamase 0.0077 0.025 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0087 0.0455
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0337 0.1308 0.313
Brugia malayi MBOAT family protein 0.0041 0.0105 0.0249
Loa Loa (eye worm) hypothetical protein 0.0141 0.0508 0.1215
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0041 0.0105 0.0249
Brugia malayi hypothetical protein 0.0141 0.0508 0.1215
Echinococcus multilocularis zinc finger transcription factor gli2 0.0301 0.1163 0.1163
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0872 0.2085
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0041 0.0105 0.0249
Echinococcus multilocularis microtubule associated protein 2 0.0731 0.2911 0.291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.033 0.0788
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0087 0.0902
Plasmodium falciparum glutathione reductase 0.0047 0.0128 0.1337
Onchocerca volvulus 0.0047 0.0127 0.066
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0031 0.0304
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0441 0.0441
Brugia malayi Pre-SET motif family protein 0.0427 0.1674 0.4005
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0105 0.0547
Loa Loa (eye worm) hypothetical protein 0.0064 0.0195 0.0465
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0105 0.0363 0.0866
Onchocerca volvulus 0.0296 0.114 0.5957
Mycobacterium tuberculosis Probable reductase 0.0107 0.0373 0.1911
Loa Loa (eye worm) hypothetical protein 0.0145 0.0526 0.1256
Leishmania major glycerol uptake protein, putative 0.0041 0.0105 0.1782
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.025 0.1276
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0087 0.0206
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0091 0.1541
Loa Loa (eye worm) MBOAT family protein 0.0041 0.0105 0.0249
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.033 0.0329
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0188 0.1978
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0108 0.0257
Echinococcus granulosus zinc finger protein 0.0042 0.0107 0.0254
Brugia malayi MH2 domain containing protein 0.0119 0.0422 0.1008
Loa Loa (eye worm) hhat protein 0.0041 0.0105 0.0249
Plasmodium vivax methionine--tRNA ligase, putative 0.0023 0.0031 0.0303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.098 0.2343
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0422 0.2163
Mycobacterium ulcerans hypothetical protein 0.0035 0.0078 0.3041
Brugia malayi beta-lactamase 0.0077 0.025 0.0597
Echinococcus multilocularis methionine tRNA synthetase 0.0061 0.0184 0.0184
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0422 0.2163
Brugia malayi Bromodomain containing protein 0.0078 0.0255 0.0609
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0041 0.0105 0.0104
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0246 0.0939 0.2246
Loa Loa (eye worm) hypothetical protein 0.0105 0.0363 0.0866
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0031 1
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0061 0.0184 0.3921
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0041 0.0105 0.0249
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0041 0.0105 0.0104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.025 0.1276
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.025 0.432
Brugia malayi CHD4 protein 0.0017 0.0007 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.025 0.0597
Plasmodium vivax SET domain protein, putative 0.0062 0.0188 0.1978
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0099 0.0515
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0188 0.0187
Echinococcus multilocularis zinc finger protein 0.0042 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0083 0.0273 0.0653
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0192
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0041 0.0105 0.0104
Brugia malayi GNT-I family protein 0.0105 0.0363 0.0866
Loa Loa (eye worm) hhat protein 0.0041 0.0105 0.0249
Loa Loa (eye worm) hypothetical protein 0.0052 0.0146 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.025 0.1307
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0031 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0061 0.0184 0.3172
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0041 0.0105 0.2152
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Brugia malayi Ets-domain containing protein 0.0074 0.0239 0.057
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0146 0.2507
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0087 0.0435
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0031 0.0304
Brugia malayi hypothetical protein 0.0033 0.0072 0.017
Echinococcus granulosus methionine tRNA synthetase 0.0061 0.0184 0.044
Brugia malayi MBOAT family protein 0.0041 0.0105 0.0249
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0078 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.025 0.432
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0441 0.1055
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0061 0.0184 0.7343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.025 0.0597
Mycobacterium tuberculosis Conserved protein 0.0077 0.025 0.1276
Chlamydia trachomatis methionine--tRNA ligase 0.0023 0.0031 0.9966
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0105 0.0547
Mycobacterium leprae conserved hypothetical protein 0.0077 0.025 0.5603
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0023 0.0031 0.1144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0188 0.0448
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0031 0.1564
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0031 0.0496
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0087 0.1474
Echinococcus granulosus GPCR family 2 0.0081 0.0266 0.0635
Loa Loa (eye worm) hypothetical protein 0.0256 0.098 0.2343
Brugia malayi diacylglycerol acyltransferase family protein 0.0157 0.0576 0.1377
Schistosoma mansoni hypothetical protein 0.0023 0.003 0.0071
Leishmania major methionyl-tRNA synthetase, putative 0.0061 0.0184 0.3172
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0157 0.0576 1
Trichomonas vaginalis porcupine, putative 0.0041 0.0105 0.0547
Entamoeba histolytica hypothetical protein 0.0108 0.0374 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.025 0.1307
Treponema pallidum alginate O-acetylation protein (algI) 0.0041 0.0105 1
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0061 0.0184 0.0937
Giardia lamblia Methionyl-tRNA synthetase 0.0061 0.0184 1
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0227 0.0542
Plasmodium falciparum methionine--tRNA ligase 0.0061 0.0184 0.1941
Onchocerca volvulus 0.0077 0.025 0.1304
Leishmania major diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Echinococcus granulosus chromobox protein 1 0.0071 0.0227 0.0542
Onchocerca volvulus 0.0077 0.025 0.1304
Schistosoma mansoni hypothetical protein 0.0175 0.0649 0.1552
Schistosoma mansoni hypothetical protein 0.0469 0.1846 0.4417
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0105 0.2152
Toxoplasma gondii tRNA ligases class I (M) protein 0.0023 0.0031 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0236 0.0235
Brugia malayi CXXC zinc finger family protein 0.0033 0.007 0.0166
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0374 0.0893
Brugia malayi beta-lactamase family protein 0.0077 0.025 0.0597
Onchocerca volvulus 0.0031 0.0064 0.033
Loa Loa (eye worm) pax transcription factor protein 2 0.0485 0.1912 0.4573
Schistosoma mansoni hypothetical protein 0.0859 0.3432 0.8212
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0422 0.1008
Entamoeba histolytica hypothetical protein 0.0108 0.0374 1
Onchocerca volvulus Huntingtin homolog 0.0141 0.0508 0.2653
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0091 0.0475
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.025 0.1276
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0091 0.1749
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.025 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.025 0.1276
Loa Loa (eye worm) hypothetical protein 0.0097 0.033 0.0788
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.025 0.432
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0014 0.0074
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0127 0.0302
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0249
Brugia malayi Pre-SET motif family protein 0.0062 0.0188 0.0448
Toxoplasma gondii hypothetical protein 0.0042 0.0105 0.1099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.098 0.2343
Echinococcus multilocularis chromobox protein 1 0.0071 0.0227 0.0226
Schistosoma mansoni hypothetical protein 0.0081 0.0266 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0099 0.0518
Schistosoma mansoni cpg binding protein 0.0039 0.0094 0.0223
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0091 0.3567
Echinococcus granulosus dnaJ subfamily B 0.0469 0.1846 0.4417
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0007 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Loa Loa (eye worm) hypothetical protein 0.0296 0.114 0.2727
Treponema pallidum leucyl-tRNA synthetase 0.0023 0.0031 0.2774
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0041 0.0105 0.2152
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0087 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Schistosoma mansoni chromobox protein 0.0071 0.0227 0.0542
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1042 0.4179 0.4179
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0246 0.0939 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0087 0.1474
Mycobacterium tuberculosis Conserved protein 0.0077 0.025 0.1276
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0087 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.033 0.0788
Toxoplasma gondii ABC1 family protein 0.0077 0.025 0.2644
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0273 0.0273
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0087 0.4646
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0072
Loa Loa (eye worm) hypothetical protein 0.0141 0.0508 0.1215
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0087 0.1474
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0246 0.0939 1
Entamoeba histolytica hypothetical protein 0.0041 0.0105 0.2152
Echinococcus granulosus chromobox protein 1 0.0071 0.0227 0.0542
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0128 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.037 0.1934
Brugia malayi methionyl-tRNA synthetase 0.0061 0.0184 0.044
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0031 0.1148
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0003 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0337 0.1308 0.313
Brugia malayi hypothetical protein 0.0052 0.0146 0.0348
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0273 0.0653
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0373 0.1911
Schistosoma mansoni inositol monophosphatase 0.0038 0.0091 0.0216
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0266 0.0635
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.003 0.0071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0198 0.1007
Schistosoma mansoni methionine-tRNA synthetase 0.0061 0.0184 0.044
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0038 0.009 0.0213
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0061 0.0184 0.0963
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0266 0.0635
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0239 0.057
Loa Loa (eye worm) MBOAT family protein 0.0041 0.0105 0.0249
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0273 0.0653
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0052 0.0269
Leishmania major glycerol uptake protein, putative 0.0041 0.0105 0.1782
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0227 0.1187
Schistosoma mansoni leucyl-tRNA synthetase 0.0023 0.0031 0.0072
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0061 0.0184 0.044
Mycobacterium ulcerans lipase LipD 0.0077 0.025 1
Trypanosoma brucei glycerol uptake protein, putative 0.0041 0.0105 0.1782
Leishmania major trypanothione reductase 0.0047 0.0128 0.2185
Brugia malayi beta-lactamase family protein 0.0077 0.025 0.0597
Schistosoma mansoni hypothetical protein 0.0047 0.0127 0.0302
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0373 0.1911
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0031 0.2784
Brugia malayi MBOAT family protein 0.0041 0.0105 0.0249
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0219 0.2312
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0422 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.098 0.2343
Echinococcus granulosus geminin 0.0859 0.3432 0.8212
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0132 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0146 0.1535
Trypanosoma cruzi ISWI complex protein 0.0031 0.0064 0.1065
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0249
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0041 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0081 0.0266 0.0635
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0337 0.1308 0.1308
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0007 0.0016
Leishmania major leucyl-tRNA synthetase, putative 0.0023 0.0031 0.0494
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0031 0.1148
Entamoeba histolytica hypothetical protein 0.0108 0.0374 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Entamoeba histolytica hypothetical protein 0.0108 0.0374 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0128 0.1337
Toxoplasma gondii exonuclease III APE 0.0037 0.0087 0.0902
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0198 0.3406
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0236 0.0562
Onchocerca volvulus 0.0041 0.0105 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0105 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0201 0.1049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0091 0.1541
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0249
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0198 0.0472
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0246 0.0939 0.2246
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0128 0.0127
Echinococcus granulosus zinc finger transcription factor gli2 0.0301 0.1163 0.2782
Schistosoma mansoni inositol monophosphatase 0.0038 0.0091 0.0216
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0128 0.0646
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0091 0.009
Plasmodium falciparum thioredoxin reductase 0.0047 0.0128 0.1337
Brugia malayi glutathione reductase 0.0047 0.0128 0.0304
Loa Loa (eye worm) hypothetical protein 0.0205 0.0771 0.1843
Brugia malayi Zinc finger, C2H2 type family protein 0.0301 0.1163 0.2782
Echinococcus granulosus sterol O acyltransferase 1 0.0041 0.0105 0.0249
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1042 0.4179 1
Onchocerca volvulus 0.0074 0.0235 0.1227
Schistosoma mansoni survival motor neuron protein 0.0047 0.0127 0.0302
Schistosoma mansoni sterol O-acyltransferase 1 0.0041 0.0105 0.0249
Loa Loa (eye worm) hypothetical protein 0.0089 0.0299 0.0714
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0108 0.0374 0.0893
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0373 0.1911
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.025 0.1307
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0023 0.0031 0.0072
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0422 0.1008
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0041 0.0105 0.0249
Toxoplasma gondii diacylglycerol acyltransferase 0.0035 0.0078 0.0804
Brugia malayi diacylglycerol acyltransferase 0.0246 0.0939 0.2246
Entamoeba histolytica vacuolar protein sorting 26 0.0041 0.0105 0.2152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1308 0.313
Schistosoma mansoni microtubule-associated protein tau 0.0731 0.2911 0.6965
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0083 0.0198
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0023 0.0031 0.1559
Schistosoma mansoni chromobox protein 0.0071 0.0227 0.0542
Toxoplasma gondii dgat2l1-prov protein 0.0157 0.0576 0.6121
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0023 0.0031 0.003
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0239 0.0238
Echinococcus multilocularis cpg binding protein 0.0039 0.0094 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0374 0.0373
Onchocerca volvulus 0.0038 0.009 0.0465
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0031 0.0496
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0091 0.0475
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0091 0.4858
Trypanosoma cruzi GUP1, putative 0.0041 0.0105 0.1782
Entamoeba histolytica hypothetical protein 0.0023 0.0031 0.0003
Treponema pallidum methionyl-tRNA synthetase 0.0023 0.0031 0.2774
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0087 0.0086
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0157 0.0576 0.1377
Giardia lamblia Leucyl-tRNA synthetase 0.0023 0.0031 0.1559
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0157 0.0576 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0128 0.0304
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0176 0.0419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0014 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0112 0.0583
Loa Loa (eye worm) hypothetical protein 0.1042 0.4179 1
Brugia malayi chromobox protein homolog 3 0.004 0.0099 0.0236
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0246 0.0939 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0035 0.0078 0.1313
Schistosoma mansoni gabp alpha 0.0074 0.0239 0.057
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.0304
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.025 0.0249
Brugia malayi Bromodomain containing protein 0.0155 0.0569 0.136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0087 0.0206
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0087 0.1636
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0198 0.0472
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0374 0.0893
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0041 0.0105 0.0249
Echinococcus multilocularis geminin 0.0859 0.3432 0.3431
Leishmania major hypothetical protein, conserved 0.0041 0.0105 0.1782
Onchocerca volvulus 0.0486 0.1914 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0198 0.7886
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0128 0.1337
Onchocerca volvulus 0.0077 0.025 0.1304
Trypanosoma brucei glycerol uptake protein, putative 0.0041 0.0105 0.1782
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0198 0.7886
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.025 0.1276
Schistosoma mansoni zinc finger protein 0.0042 0.0107 0.0254
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0036 0.0081 0.0835
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.025 0.1276
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0031 0.0303
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0872 0.0871
Schistosoma mansoni ets-related 0.0226 0.0856 0.2046
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0146 0.2507
Loa Loa (eye worm) hypothetical protein 0.004 0.0099 0.0236
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0373 0.1911
Onchocerca volvulus 0.0485 0.1912 0.9989
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0105 0.0363 0.0866
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0373 0.8753
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0246 0.0939 0.2246
Brugia malayi PHD-finger family protein 0.0053 0.0151 0.0361
Schistosoma mansoni hypothetical protein 0.0081 0.0266 0.0635
Trichomonas vaginalis set domain proteins, putative 0.0486 0.1914 1
Trypanosoma cruzi ISWI complex protein 0.0031 0.0064 0.1065
Brugia malayi methionyl-tRNA synthetase 0.0023 0.0031 0.0072
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0041 0.0105 0.0249
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0373 0.1911
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0078 0.0185
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.033 0.0788
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0266 0.0635
Leishmania major glycerol uptake protein, putative 0.0041 0.0105 0.1782
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.003 0.003
Brugia malayi MBOAT family protein 0.0041 0.0105 0.0249
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.0649 0.1552
Loa Loa (eye worm) hypothetical protein 0.0077 0.025 0.0597
Trypanosoma cruzi glycerol uptake protein, putative 0.0041 0.0105 0.1782
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0112 0.0579

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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