Detailed information for compound 1330634

Basic information

Technical information
  • TDR Targets ID: 1330634
  • Name: [4-[di(phenyl)methyl]piperazin-1-yl]-(1-methy lsulfonylpiperidin-4-yl)methanone
  • MW: 441.586 | Formula: C24H31N3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)C)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C24H31N3O3S/c1-31(29,30)27-14-12-22(13-15-27)24(28)26-18-16-25(17-19-26)23(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-11,22-23H,12-19H2,1H3
  • InChiKey: KXSROBQZJVCMNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[di(phenyl)methyl]piperazin-1-yl]-(1-methylsulfonyl-4-piperidyl)methanone
  • [4-[di(phenyl)methyl]-1-piperazinyl]-(1-methylsulfonyl-4-piperidinyl)methanone
  • [4-[di(phenyl)methyl]piperazin-1-yl]-(1-mesyl-4-piperidyl)methanone
  • 1-(diphenylmethyl)-4-{[1-(methylsulfonyl)-4-piperidinyl]carbonyl}piperazine
  • MLS000693207
  • SMR000299625
  • STK102103
  • AH-487/41730149

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii target of rapamycin (TOR), putative 0.0054 0.0414 0.1664
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.0545 0.0936
Mycobacterium ulcerans beta-lactamase 0.0115 0.1126 0.2813
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0518 0.0628
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.038 0.1425
Loa Loa (eye worm) hypothetical protein 0.0034 0.0192 0.0329
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0594 0.0707
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.038 0.0453
Toxoplasma gondii ABC1 family protein 0.0115 0.1126 0.4596
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0056 0.0446 0.1678
Giardia lamblia Cysteine protease 0.0056 0.0446 0.2077
Brugia malayi polk-prov protein 0.0019 0.002 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0205 0.0253
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.038 0.1425
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0518 0.0617
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0794 0.0946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.031 0.1154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0545 0.2059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0183 0.0313
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0056 0.0446 0.1796
Giardia lamblia Cathepsin B precursor 0.0056 0.0446 0.2077
Plasmodium falciparum serine repeat antigen 4 0.0056 0.0446 0.1796
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0794 0.0794
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0414 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0518 0.1957
Loa Loa (eye worm) inositol-1 0.0042 0.0278 0.0477
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0183 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.044 0.1657
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1362 0.1633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0131 0.1313 0.5014
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.014 0.0169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0358 0.0358
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0278 0.0347
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0414 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.031 0.1154
Brugia malayi Cathepsin L-like precursor 0.0154 0.1571 0.2698
Echinococcus multilocularis GPCR, family 2 0.0086 0.0794 0.0794
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0522 0.5823 0.7525
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0446 0.1678
Schistosoma mansoni hypothetical protein 0.004 0.0259 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0309 0.1152
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0026 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0227 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0545 0.2059
Leishmania major DNA damage repair protein, putative 0.0019 0.002 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0183 0.0313
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0035 0.0205 0.0248
Schistosoma mansoni cathepsin F (C01 family) 0.0154 0.1571 0.1904
Entamoeba histolytica cysteine proteinase, putative 0.0131 0.1313 0.5333
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0183 0.0183
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0205 0.0352
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0446 0.0766
Giardia lamblia Cathepsin B precursor 0.0056 0.0446 0.2077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0075 0.0662 0.1138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0183 0.0217
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.038 0.1525
Mycobacterium tuberculosis Conserved protein 0.0115 0.1126 0.1347
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0287 1
Echinococcus granulosus cathepsin L 0.0056 0.0446 0.0531
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0287 0.0359
Trypanosoma cruzi cysteine proteinase, putative 0.0131 0.1313 0.1686
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.1126 0.2813
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1362 0.1633
Toxoplasma gondii cathepsin B 0.02 0.2109 0.8644
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0446 0.1678
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0287 0.0493
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0065 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0262 0.097
Echinococcus granulosus zinc finger protein 0.0026 0.0092 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0518 0.1281
Plasmodium falciparum cysteine proteinase falcipain 3 0.0229 0.2438 1
Entamoeba histolytica hypothetical protein 0.004 0.0259 0.0963
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0081 0.0097
Entamoeba histolytica Ran family GTPase 0.0025 0.0087 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Echinococcus granulosus snurportin 1 0.0366 0.4024 0.4792
Schistosoma mansoni cathepsin F (C01 family) 0.0229 0.2438 0.2954
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0423 0.1701
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0912 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0183 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0051 0.0088
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0117 0.0412
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0183 0.0217
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0446 0.1286
Schistosoma mansoni ran 0.0025 0.0087 0.0106
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0067 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0736 0.8294 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0229 0.2438 0.2904
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0259 0.0314
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.1716 0.2079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0183 0.0221
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1517 0.1517
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0183 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.1126 0.1341
Schistosoma mansoni cathepsin s 0.0075 0.0662 0.0803
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0056 0.0446 0.1796
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0446 0.1678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0056 0.0446 0.1796
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0065 0.0545 0.0693
Echinococcus granulosus importin subunit beta 1 0.0034 0.0192 0.0228
Loa Loa (eye worm) hypothetical protein 0.0154 0.1571 0.2698
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0183 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0336 0.1255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0358 0.0434
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.1055 0.1278
Giardia lamblia Hypothetical protein 0.0056 0.0446 0.2077
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Giardia lamblia Encystation-specific protease 0.0056 0.0446 0.2077
Brugia malayi steroid hormone receptor 0.0034 0.0183 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0229 0.2438 0.9345
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0037 0.0219 0.0265
Giardia lamblia Hypothetical protein 0.0056 0.0446 0.2077
Echinococcus granulosus cathepsin L 0.0131 0.1313 0.1563
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1126 0.4596
Toxoplasma gondii preprocathepsin c precursor, putative 0.0056 0.0446 0.1796
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0511 0.0619
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0446 0.0766
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.002 0.0013
Brugia malayi Muscleblind-like protein 0.0149 0.1517 0.2606
Brugia malayi Cathepsin L-like cysteine proteinase 0.0154 0.1571 0.2698
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.002 0.0042
Brugia malayi cathepsin L-like cysteine proteinase 0.0056 0.0446 0.0766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1577 0.1878
Brugia malayi latrophilin 2 splice variant baaae 0.0187 0.1953 0.3353
Loa Loa (eye worm) hypothetical protein 0.0075 0.0662 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0183 0.0313
Echinococcus multilocularis geminin 0.0205 0.2158 0.2158
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0183 0.0313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0794 0.0946
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0093
Plasmodium falciparum serine repeat antigen 1 0.0056 0.0446 0.1796
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0183 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.044 0.1657
Trypanosoma cruzi cysteine protease, putative 0.0131 0.1313 0.1686
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0087 0.0369
Brugia malayi PHD-finger family protein 0.0031 0.0156 0.0267
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0065 0.0545 0.066
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0075 0.0662 0.1138
Echinococcus granulosus dnaJ subfamily B 0.0408 0.451 0.5371
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0423 0.1701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0183 0.0313
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0287 0.0359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Echinococcus multilocularis cathepsin b 0.0522 0.5823 0.5823
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0229 0.2438 0.2438
Loa Loa (eye worm) beta-lactamase 0.0115 0.1126 0.1933
Leishmania major cathepsin L-like protease 0.0229 0.2438 0.3143
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.1126 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0205 0.0751
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0081 0.0081
Leishmania major hypothetical protein, conserved 0.0054 0.0423 0.0535
Plasmodium vivax vivapain-2 0.0229 0.2438 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0626
Echinococcus granulosus dna polymerase eta 0.0063 0.0518 0.0617
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.038 0.1525
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0423 0.1701
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0594 0.0594
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0518 0.0658
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.002 0.0013
Giardia lamblia Cathepsin B precursor 0.02 0.2109 1
Brugia malayi cathepsin L precursor 0.0056 0.0446 0.0766
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0518 0.0658
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0518 0.0658
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Brugia malayi Importin beta-1 subunit 0.0034 0.0192 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0294 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.044 0.1657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Onchocerca volvulus 0.0031 0.0156 0.012
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0056 0.0446 0.1796
Schistosoma mansoni cathepsin S (C01 family) 0.0056 0.0446 0.054
Loa Loa (eye worm) hypothetical protein 0.0046 0.0324 0.0556
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0567 0.0567
Leishmania major DNA polymerase eta, putative 0.0019 0.002 0.0013
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0414 0.071
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0287 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.1716 0.1716
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0127 0.0217
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0594 0.0705
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0306 0.1219
Giardia lamblia Cysteine protease 0.0056 0.0446 0.2077
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0065 0.0545 0.2149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0446 0.1678
Giardia lamblia Cathepsin B precursor 0.0056 0.0446 0.2077
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1126 0.4295
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1126 0.4295
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0278 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0183 0.0221
Trypanosoma cruzi major cysteine proteinase, putative 0.011 0.106 0.1359
Schistosoma mansoni DNA polymerase eta 0.0063 0.0518 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0156 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0183 0.0313
Brugia malayi Pre-SET motif family protein 0.0031 0.0156 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Leishmania major DNA polymerase kappa, putative 0.0019 0.002 0.0013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0278 0.9672
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Giardia lamblia DINP protein human, muc B family 0.0063 0.0518 0.2422
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0056 0.0446 0.1796
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1126 0.1364
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0517 0.0887
Echinococcus granulosus cpg binding protein 0.0032 0.0168 0.02
Plasmodium vivax vivapain-1 0.0131 0.1313 0.5365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0235 0.0868
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.1126 0.1347
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0794 0.1364
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0221 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0183 0.0313
Onchocerca volvulus 0.0115 0.1126 0.4026
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0229 0.2438 0.9345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0136 0.0162
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0087 0.0319
Loa Loa (eye worm) hypothetical protein 0.0063 0.0518 0.089
Toxoplasma gondii thioredoxin reductase 0.0054 0.0414 0.1663
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0065 0.0545 0.0693
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0097 0.0912 0.1168
Loa Loa (eye worm) ctsf protein 0.0229 0.2438 0.4187
Schistosoma mansoni cathepsin C 0.0056 0.0446 0.054
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0423 0.1701
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0183 0.0221
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0065 0.0545 0.0693
Mycobacterium tuberculosis Conserved protein 0.0115 0.1126 0.1347
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0414 0.0523
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1126 0.1364
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0117 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0183 0.0313
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.002 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1126 0.1445
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1362 0.1633
Leishmania major cathepsin L-like protease 0.0282 0.3052 0.3938
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Onchocerca volvulus 0.0229 0.2438 0.9315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0037 0.0219 0.0271
Schistosoma mansoni ap endonuclease 0.0043 0.0287 0.0348
Loa Loa (eye worm) hypothetical protein 0.0229 0.2438 0.4187
Onchocerca volvulus Cathepsin L homolog 0.0229 0.2438 0.9315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1577 0.1577
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.1126 0.1347
Brugia malayi Thioredoxin reductase 0.0054 0.0414 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0235 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1313 0.1686
Entamoeba histolytica cysteine proteinase, putative 0.0131 0.1313 0.5333
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0037 0.0219 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0626
Entamoeba histolytica cysteine proteinase 2 0.0131 0.1313 0.5333
Onchocerca volvulus 0.0229 0.2438 0.9315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0205 0.0751
Leishmania major hypothetical protein, conserved 0.0115 0.1126 0.1445
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0518 0.1957
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0035 0.0205 0.0253
Plasmodium falciparum serine repeat antigen 6 0.0056 0.0446 0.1796
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0229 0.2438 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0056 0.0446 0.0766
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0309 0.1152
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0522 0.5823 0.7056
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0326 0.3553 0.4587
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0594 0.2404
Echinococcus granulosus tumor protein p63 0.0745 0.8397 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0366 0.1372
Toxoplasma gondii hypothetical protein 0.0111 0.1076 0.4392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0309 0.1152
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Echinococcus multilocularis tumor protein p63 0.0745 0.8397 0.8397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.1571 0.601
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0056 0.0446 0.2077
Entamoeba histolytica hypothetical protein 0.0037 0.0219 0.0798
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0035 0.0205 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0013
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1205 0.1443
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0278 0.0347
Trypanosoma brucei trypanothione reductase 0.0054 0.0414 0.0523
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.001 0.0012
Loa Loa (eye worm) cathepsin B 0.02 0.2109 0.3622
Entamoeba histolytica hypothetical protein 0.004 0.0259 0.0963
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0518 0.0658
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Echinococcus granulosus geminin 0.0205 0.2158 0.2569
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0183 0.0225
Mycobacterium tuberculosis Conserved protein 0.0115 0.1126 0.1347
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0594 0.0756
Giardia lamblia DNA damage repair protein 0.0019 0.002 0.0048
Echinococcus multilocularis cathepsin b 0.0522 0.5823 0.5823
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0278 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0219 0.0805
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.02 0.2109 0.2555
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0423 0.0535
Entamoeba histolytica hypothetical protein 0.004 0.0259 0.0963
Onchocerca volvulus 0.0229 0.2438 0.9315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0446 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.031 0.1154
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0205 0.0352
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0087 0.01
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0056 0.0441 0.0558
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0594 0.0719
Echinococcus multilocularis snurportin 1 0.0366 0.4024 0.4024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0091
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Entamoeba histolytica hypothetical protein 0.0028 0.0117 0.0375
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0087 0.01
Loa Loa (eye worm) hypothetical protein 0.0522 0.5823 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.044 0.1657
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0056 0.0446 0.1678
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1126 0.1445
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.1577 0.1878
Schistosoma mansoni hypothetical protein 0.0021 0.004 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0183 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0518 0.089
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0446 0.0766
Onchocerca volvulus 0.0109 0.1055 0.3739
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0056 0.0446 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Brugia malayi beta-lactamase 0.0115 0.1126 0.1933
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0026 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0064
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Entamoeba histolytica cysteine proteinase, putative 0.0154 0.1571 0.6406
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0056 0.0446 0.1678
Brugia malayi glutathione reductase 0.0054 0.0414 0.071
Loa Loa (eye worm) acetyltransferase 0.0166 0.1716 0.2947
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.1126 0.1933
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0183 0.0313
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0056 0.0446 0.2077
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0205 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0087 0.0104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0183 0.0313
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0056 0.0446 0.2077
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0065 0.0545 0.2149
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1205 0.1443
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0414 0.0492
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0446 0.054
Trichomonas vaginalis esterase, putative 0.0115 0.1126 0.4295
Leishmania major cathepsin L-like protease 0.0282 0.3052 0.3938
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0183 0.0313
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0688 0.7736 1
Echinococcus granulosus cathepsin L cysteine protease 0.0131 0.1313 0.1563
Brugia malayi Pre-SET motif family protein 0.0214 0.2268 0.3894
Loa Loa (eye worm) hypothetical protein 0.003 0.014 0.0241
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.02 0.2109 0.2717
Leishmania major cathepsin L-like protease 0.0229 0.2438 0.3143
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Leishmania major GTP-binding protein, putative 0.0025 0.0087 0.01
Brugia malayi hypothetical protein 0.004 0.0259 0.0444
Trypanosoma brucei unspecified product 0.0043 0.0294 0.0368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Loa Loa (eye worm) hypothetical protein 0.0109 0.1055 0.1811
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0087 0.0319
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0594 0.1471
Brugia malayi Inositol-1 0.0042 0.0278 0.0477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.1577 0.2708
Trypanosoma cruzi cysteine proteinase, putative 0.0131 0.1313 0.1686
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0183 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1577 0.1911
Brugia malayi MH2 domain containing protein 0.0141 0.1424 0.2445
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0594 0.0719
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0567 0.0675
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0287 0.108
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1205 0.1443
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0306 0.141
Echinococcus granulosus cathepsin l1 0.0154 0.1571 0.1871
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0794 0.1364
Schistosoma mansoni bromodomain containing protein 0.0071 0.0609 0.0738
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0183 0.0313
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0278 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0358 0.0434
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0688 0.7736 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0517 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0446 0.1678
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0205 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0183 0.0313
Plasmodium falciparum serine repeat antigen 8 0.0056 0.0446 0.1796
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Trypanosoma cruzi cruzipain precursor, putative 0.0282 0.3052 0.3938
Echinococcus multilocularis dna polymerase eta 0.0063 0.0518 0.0518
Mycobacterium ulcerans lipase LipD 0.0115 0.1126 0.2813
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0294 0.0368
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0518 0.0628
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.1126 0.1347
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1205 0.8614
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0056 0.0446 0.1678
Trypanosoma cruzi cysteine peptidase, putative 0.0229 0.2438 0.3143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.1126 0.1126
Loa Loa (eye worm) phosphatidylinositol 3 0.0065 0.0545 0.0936
Echinococcus granulosus microtubule associated protein 2 0.0733 0.8253 0.9828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0287 0.1067
Plasmodium vivax unspecified product 0.0075 0.0662 0.2688
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0278 0.1104
Brugia malayi Bromodomain containing protein 0.0043 0.0295 0.0507
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0287 0.0359
Loa Loa (eye worm) hypothetical protein 0.0072 0.0632 0.1086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0056 0.0446 0.1796
Toxoplasma gondii exonuclease III APE 0.0043 0.0287 0.1141
Giardia lamblia Cathepsin B precursor 0.02 0.2109 1
Mycobacterium ulcerans hypothetical protein 0.0362 0.3978 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0183 0.0183
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0517 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0517 0.0517
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.002 0.0024
Mycobacterium tuberculosis Probable reductase 0.0122 0.1205 0.1443
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0278 0.1042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0326 0.3553 0.4587
Leishmania major DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0183 0.0313
Schistosoma mansoni hypothetical protein 0.0366 0.4024 0.4876
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Giardia lamblia Cysteine protease 0.0056 0.0446 0.2077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1313 0.1686
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0192 0.0749
Brugia malayi cathepsin L-like precursor 0.0154 0.1571 0.2698
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0087 0.01
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0081 0.0098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0131 0.1313 0.159
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0045
Echinococcus multilocularis cpg binding protein 0.0032 0.0168 0.0168
Onchocerca volvulus 0.0229 0.2438 0.9315
Trypanosoma brucei unspecified product 0.0063 0.0518 0.0658
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0287 0.0287
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0056 0.0446 0.2077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.044 0.1657
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1126 0.4295
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0065 0.0545 0.0649
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0056 0.0446 0.1796
Schistosoma mansoni ran 0.0025 0.0087 0.0106
Onchocerca volvulus 0.0229 0.2438 0.9315
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0287 0.0493
Entamoeba histolytica cysteine proteinase, putative 0.0131 0.1313 0.5333
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1362 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0273 0.2951 0.5068
Trypanosoma brucei unspecified product 0.0043 0.0294 0.0368
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0035 0.0205 0.0205
Brugia malayi nuclear hormone receptor 0.0034 0.0183 0.0313
Giardia lamblia Cathepsin L-like protease 0.0056 0.0446 0.2077
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0287 0.1067
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0087 0.015
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0626
Brugia malayi RNA, U transporter 1 0.0098 0.0922 0.1583
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.002 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0156 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2608 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0205 0.0253
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0326 0.3553 0.4587
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0156 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.002 0.0013
Leishmania major cysteine peptidase A (CPA) 0.0229 0.2438 0.3143
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0183 0.0183
Plasmodium falciparum serine repeat antigen 3 0.0056 0.0446 0.1796
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.451 0.451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0131 0.1313 0.5014
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Toxoplasma gondii FATC domain-containing protein 0.0037 0.0219 0.0862
Brugia malayi Papain family cysteine protease containing protein 0.0131 0.1313 0.2254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.001 0.0012
Plasmodium vivax importin-beta 2, putative 0.0034 0.0192 0.0749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0522 0.5823 0.7056
Brugia malayi cathepsin B-like cysteine proteinase 0.0522 0.5823 1
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0662 0.0845
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0259 0.0308
Leishmania major cathepsin L-like protease 0.0282 0.3052 0.3938
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.1126 0.1347
Loa Loa (eye worm) hypothetical protein 0.0149 0.1517 0.2606
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0229 0.2438 0.4187
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0053 0.0166
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0183 0.0313
Brugia malayi Bromodomain containing protein 0.0083 0.0748 0.1285
Brugia malayi hypothetical protein 0.0035 0.0201 0.0344
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.004 0.0068
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Leishmania major trypanothione reductase 0.0054 0.0414 0.0523
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.8253 0.8253
Loa Loa (eye worm) RNA binding protein 0.0062 0.0517 0.0887
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.1126 0.1347
Schistosoma mansoni hypothetical protein 0.0205 0.2158 0.2614
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.0053 0.0177
Loa Loa (eye worm) hypothetical protein 0.0075 0.0662 0.1138
Schistosoma mansoni inositol monophosphatase 0.0042 0.0278 0.0337
Loa Loa (eye worm) hypothetical protein 0.0086 0.0794 0.1364
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0219 0.0376
Leishmania major cathepsin L-like protease 0.0229 0.2438 0.3143
Echinococcus granulosus muscleblind protein 0.0149 0.1517 0.1807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Echinococcus multilocularis cathepsin L cysteine protease 0.0229 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Loa Loa (eye worm) glutathione reductase 0.0054 0.0414 0.071
Schistosoma mansoni hypothetical protein 0.0086 0.0794 0.0962
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0056 0.0446 0.1796
Schistosoma mansoni coup transcription factor 0.0034 0.0183 0.0221
Schistosoma mansoni cpg binding protein 0.0032 0.0168 0.0204
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.1635 0.1947
Trypanosoma cruzi target of rapamycin kinase 3 0.0056 0.0441 0.0558
Brugia malayi cathepsin Z-like cysteine proteinase 0.0056 0.0446 0.0766
Onchocerca volvulus 0.0154 0.1571 0.5822
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0183 0.0221
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0056 0.0446 0.1739
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0229 0.2438 0.2438
Schistosoma mansoni cpg binding protein 0.0032 0.0168 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1126 0.4295
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0287 0.0335
Giardia lamblia Cathepsin B precursor 0.0056 0.0446 0.2077
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.1424 0.2445
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0183 0.0217
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0278 0.1032
Plasmodium vivax SET domain protein, putative 0.0031 0.0156 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Brugia malayi beta-lactamase family protein 0.0115 0.1126 0.1933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0183 0.0313
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0087 0.0087
Schistosoma mansoni importin beta-1 0.0034 0.0192 0.0232
Toxoplasma gondii cathepsin CPL 0.0229 0.2438 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0183 0.0313
Onchocerca volvulus 0.0229 0.2438 0.9315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0522 0.5823 0.7056
Giardia lamblia GTOR 0.0065 0.0545 0.2549
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.1571 0.601
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Plasmodium falciparum serine repeat antigen 5 0.0056 0.0446 0.1796
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0056 0.0446 0.1796
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0518 0.0614
Brugia malayi hypothetical protein 0.0054 0.0423 0.0726
Schistosoma mansoni hypothetical protein 0.0187 0.1953 0.2366
Echinococcus granulosus serine protein kinase ATM 0.0037 0.0219 0.0261
Onchocerca volvulus 0.0115 0.1126 0.4026
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0065 0.0545 0.0693
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0518 0.2039
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0518 0.0614
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0518 0.089
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0097 0.0912 0.1168
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.038 0.1525
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.3052 0.3938
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0366 0.4024 0.6911
Plasmodium falciparum importin beta, putative 0.0034 0.0192 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0183 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0626
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0131 0.1313 0.159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0365 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0039 0.025 0.0428
Loa Loa (eye worm) hypothetical protein 0.0187 0.1953 0.3353
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0157 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0518 0.0658
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0446 0.054
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0183 0.0313
Plasmodium vivax unspecified product 0.0056 0.0446 0.1796
Brugia malayi Cathepsin L-like precursor 0.0075 0.0662 0.1138
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0518 0.0518
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0183 0.0221
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0056 0.0446 0.054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0594 0.1471
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0287 0.0698
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0278 0.0676
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.8253 1
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0183 0.0221
Echinococcus granulosus dna polymerase kappa 0.0063 0.0518 0.0617
Mycobacterium leprae conserved hypothetical protein 0.0115 0.1126 0.7916
Giardia lamblia Cathepsin L precursor 0.0056 0.0446 0.2077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0131 0.1313 0.159
Schistosoma mansoni hypothetical protein 0.0086 0.0794 0.0962
Leishmania major phosphatidylinositol kinase related protein, putative 0.0023 0.0067 0.0074
Plasmodium falciparum glutathione reductase 0.0054 0.0414 0.1663
Brugia malayi cathepsin F-like cysteine proteinase 0.0075 0.0662 0.1138
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0278 0.0347
Schistosoma mansoni hypothetical protein 0.0205 0.2158 0.2614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Brugia malayi RNA binding protein 0.0062 0.0517 0.0887
Echinococcus multilocularis serine protein kinase ATM 0.0037 0.0219 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0517 0.0626
Entamoeba histolytica cysteine protease, putative 0.0229 0.2438 1
Plasmodium vivax unspecified product 0.0131 0.1313 0.5365
Echinococcus granulosus GPCR family 2 0.0086 0.0794 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Onchocerca volvulus 0.0229 0.2438 0.9315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0156 0.019
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0056 0.0446 0.1796
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0083 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0287 0.1141
Toxoplasma gondii cathepsin CPC1 0.0056 0.0446 0.1796
Brugia malayi Papain family cysteine protease containing protein 0.0131 0.1313 0.2254
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0446 0.0564
Plasmodium vivax glutathione reductase, putative 0.0054 0.0414 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Brugia malayi beta-lactamase family protein 0.0115 0.1126 0.1933
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0087 0.0319
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0183 0.0221
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0065 0.0545 0.0693
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1205 0.1443
Schistosoma mansoni cathepsin F (C01 family) 0.0229 0.2438 0.2954
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0056 0.0446 0.1739
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0115 0.1126 0.1933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Mycobacterium tuberculosis Conserved hypothetical protein 0.0362 0.3978 0.479
Loa Loa (eye worm) hypothetical protein 0.0149 0.1517 0.2606
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0086 0.0794 0.0962
Echinococcus granulosus cysteine protease 0.0131 0.1313 0.1563
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0229 0.2438 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0192 0.0236
Echinococcus multilocularis cathepsin L 0.0056 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.031 0.1154
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0273 0.2951 0.5068
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0035 0.0205 0.0253
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0192 0.0236
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1126 0.4295
Plasmodium vivax vivapain-2 0.0229 0.2438 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0205 0.0751
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0594 0.1471
Plasmodium vivax serine-repeat antigen (SERA) 0.0056 0.0446 0.1796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1577 0.1911
Onchocerca volvulus 0.0034 0.0183 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0545 0.2059
Schistosoma mansoni zinc finger protein 0.0026 0.0092 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0446 0.1678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0336 0.1255
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Echinococcus multilocularis muscleblind protein 0.0149 0.1517 0.1517
Toxoplasma gondii cathepsin CPC2 0.0056 0.0446 0.1796
Mycobacterium leprae Probable lipase LipE 0.0115 0.1126 0.7916
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Onchocerca volvulus Cathepsin F homolog 0.0229 0.2438 0.9315
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0446 0.1678
Leishmania major cathepsin L-like protease 0.0229 0.2438 0.3143
Loa Loa (eye worm) hypothetical protein 0.0056 0.0446 0.0766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0273 0.2951 0.5068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0205 0.0751
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0412
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0287 0.1141
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0518 0.1281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0288 0.1071
Mycobacterium ulcerans hypothetical protein 0.0019 0.002 0.0026
Leishmania major importin beta-1 subunit, putative 0.0028 0.0117 0.0139
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0358 0.0426
Loa Loa (eye worm) fibroinase 0.0229 0.2438 0.4187
Loa Loa (eye worm) hypothetical protein 0.0049 0.0358 0.0615
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0087 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0446 0.1678
Echinococcus multilocularis zinc finger protein 0.0026 0.0092 0.0092
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.002 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0235 0.0868
Brugia malayi Cathepsin L-like precursor 0.0154 0.1571 0.2698
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0026 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1126 0.1445
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0183 0.0221
Leishmania major DNA polymerase eta, putative 0.0063 0.0518 0.0658
Giardia lamblia Cysteine protease 0.0056 0.0446 0.2077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.1577 0.2708
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0183 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0229 0.2438 0.9315
Trypanosoma brucei cysteine peptidase C (CPC) 0.02 0.2109 0.2717
Mycobacterium ulcerans hypothetical protein 0.0115 0.1126 0.2813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0414 0.1555
Echinococcus granulosus tar DNA binding protein 0.0062 0.0517 0.0615
Trichomonas vaginalis ran, putative 0.0025 0.0087 0.0298
Plasmodium falciparum serine repeat antigen 9 0.0056 0.0446 0.1796
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0056 0.0446 0.1796
Brugia malayi CXXC zinc finger family protein 0.0029 0.0127 0.0217
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0287 0.132
Giardia lamblia Cathepsin B precursor 0.02 0.2109 1
Plasmodium vivax vivapain-3 0.0131 0.1313 0.5365
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.051 0.2061
Onchocerca volvulus 0.0056 0.0446 0.1286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1313 0.1686
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0794 0.0794
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0518 0.0518
Echinococcus granulosus cathepsin l1 0.0229 0.2438 0.2904
Onchocerca volvulus 0.0244 0.2608 1
Plasmodium falciparum serine repeat antigen 2 0.0056 0.0446 0.1796
Brugia malayi cathepsin F-like cysteine proteinase 0.0056 0.0446 0.0766
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0056 0.0446 0.0766
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Brugia malayi Cathepsin L-like precursor 0.0229 0.2438 0.4187
Echinococcus granulosus cathepsin b 0.0522 0.5823 0.6935
Schistosoma mansoni inositol monophosphatase 0.0042 0.0278 0.0337
Schistosoma mansoni cpg binding protein 0.0029 0.0127 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0446 0.054
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.3052 0.3938
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0183 0.0221
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0287 0.0342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0183 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0229 0.2438 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0077 0.0092
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0056 0.0446 0.1796
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0183 0.0221
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0205 0.0253
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0518 0.089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2268 0.3894
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0446 0.0766
Brugia malayi ecdysteroid receptor 0.0034 0.0183 0.0313
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.002 0.0042
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0097 0.0912 0.1168
Loa Loa (eye worm) hypothetical protein 0.0034 0.0183 0.0313
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1205 0.1443
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0221 0.0221
Echinococcus multilocularis cysteine protease 0.0229 0.2438 0.2438
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0131 0.1313 0.1686
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0287 0.0359
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0662 0.0845
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Echinococcus granulosus cathepsin b 0.0522 0.5823 0.6935
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0183 0.0217
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0056 0.0446 0.054
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0518 0.0658
Echinococcus multilocularis cathepsin L cysteine protease 0.0229 0.2438 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Schistosoma mansoni cathepsin B (C01 family) 0.0056 0.0446 0.054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0183 0.0217
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.1716 0.2947
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0026 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0013
Entamoeba histolytica cysteine protease, putative 0.0131 0.1313 0.5333
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0056 0.0446 0.1796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Loa Loa (eye worm) hypothetical protein 0.0154 0.1571 0.2698
Onchocerca volvulus 0.0115 0.1126 0.4026
Leishmania major cathepsin L-like protease 0.0229 0.2438 0.3143
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0229 0.2438 0.4187
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.3052 0.3938
Entamoeba histolytica cysteine protease, putative 0.0056 0.0446 0.1739
Entamoeba histolytica hypothetical protein 0.0056 0.0446 0.1739
Leishmania major mitochondrial DNA polymerase beta 0.0688 0.7736 1
Giardia lamblia Cathepsin L-like protease 0.0056 0.0446 0.2077
Brugia malayi TAR-binding protein 0.0062 0.0517 0.0887
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3052 0.3938
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.1126 0.2813
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0056 0.0446 0.054
Schistosoma mansoni ap endonuclease 0.0043 0.0287 0.0348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.1577 0.1911
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0306 0.1158
Brugia malayi fibroinase precursor 0.0056 0.0446 0.0766
Brugia malayi nuclear receptor NHR-88 0.0034 0.0183 0.0313
Echinococcus granulosus cathepsin l cysteine peptidase 0.0229 0.2438 0.2904
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0183 0.0221
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.02 0.2109 0.2717
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0294 0.0368
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.1126 0.1347
Schistosoma mansoni hypothetical protein 0.0408 0.451 0.5465
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0446 0.054
Entamoeba histolytica cysteine proteinase, putative 0.0131 0.1313 0.5333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0183 0.0313
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0688 0.7736 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0056 0.0446 0.0766
Plasmodium vivax serine-repeat antigen (SERA) 0.0056 0.0446 0.1796
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0446 0.0766
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0518 0.0658
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0118 0.1156 0.1484
Plasmodium falciparum thioredoxin reductase 0.0054 0.0414 0.1663
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.002 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.002 0.0013
Echinococcus multilocularis cysteine protease 0.0229 0.2438 0.2438
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.1126 0.1933
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0086 0.0794 0.0962
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0207 0.2186 0.2816
Entamoeba histolytica cysteine proteinase, putative 0.0229 0.2438 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0154 0.1571 0.2698
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0423 0.0535
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0446 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.2438 0.9345
Brugia malayi Papain family cysteine protease containing protein 0.0229 0.2438 0.4187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0183 0.0313
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0522 0.5823 0.7056
Plasmodium falciparum cysteine proteinase falcipain 1 0.0131 0.1313 0.5365
Entamoeba histolytica cysteine proteinase 1, putative 0.0131 0.1313 0.5333
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.1424 0.2445
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0183 0.0221
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0056 0.0441 0.0558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0183 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.02 0.2109 0.8078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0794 0.1364
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0278 0.1032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0446 0.1678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.2438 0.9345
Plasmodium falciparum serine repeat antigen 7 0.0056 0.0446 0.1796
Giardia lamblia Cathepsin B precursor 0.0056 0.0446 0.2077
Loa Loa (eye worm) hypothetical protein 0.0075 0.0662 0.1138
Loa Loa (eye worm) hypothetical protein 0.0054 0.0423 0.0726
Loa Loa (eye worm) hypothetical protein 0.0273 0.2951 0.5068
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0423 0.0535
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0414 0.0487
Echinococcus multilocularis cathepsin L 0.0131 0.1313 0.1313
Loa Loa (eye worm) cysteine protease 0.0229 0.2438 0.4187
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0065 0.0545 0.0693
Entamoeba histolytica hypothetical protein 0.004 0.0259 0.0963

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.92 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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