Detailed information for compound 1338037

Basic information

Technical information
  • TDR Targets ID: 1338037
  • Name: N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-4-(3 ,5-dimethylpyrazol-1-yl)benzamide
  • MW: 432.924 | Formula: C20H21ClN4O3S
  • H donors: 1 H acceptors: 4 LogP: 3.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c(c1)C)c1ccc(cc1)C(=O)Nc1cc(ccc1Cl)S(=O)(=O)N(C)C
  • InChi: 1S/C20H21ClN4O3S/c1-13-11-14(2)25(23-13)16-7-5-15(6-8-16)20(26)22-19-12-17(9-10-18(19)21)29(27,28)24(3)4/h5-12H,1-4H3,(H,22,26)
  • InChiKey: JCBWFUDCLOMGHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-4-(3,5-dimethyl-1-pyrazolyl)benzamide
  • T0508-7578
  • MLS000395030
  • SMR000248468

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0207 0.0207
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.008 0.089 0.1937
Loa Loa (eye worm) hypothetical protein 0.0703 0.8927 1
Brugia malayi G-protein coupled receptor 0.0027 0.0207 0.0221
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0171 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0056
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1481 0.1606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Entamoeba histolytica hypothetical protein 0.0043 0.0419 0.105
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.109 0.3114
Brugia malayi Pre-SET motif family protein 0.0059 0.0626 0.0691
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Schistosoma mansoni hypothetical protein 0.0027 0.0207 0.0231
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.001 0.0011
Schistosoma mansoni multidrug resistance protein 0.0021 0.0125 0.014
Plasmodium vivax vivapain-3 0.0017 0.0078 0.0025
Echinococcus granulosus cathepsin l1 0.0033 0.0284 0.0319
Onchocerca volvulus 0.0048 0.0477 0.0795
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0078 0.0025
Brugia malayi FAD binding domain containing protein 0.0703 0.8927 1
Leishmania major cathepsin L-like protease 0.0126 0.1481 0.1606
Leishmania major cytochrome-b5 reductase, putative 0.008 0.089 0.0939
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.125 0.1401
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.8575 0.9605
Brugia malayi hypothetical protein 0.0286 0.3542 0.3962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0179 0.0197
Giardia lamblia Nitric oxide synthase, inducible 0.0623 0.7896 1
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0284 0.0467
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Echinococcus granulosus g protein coupled receptor 0.0027 0.0207 0.0231
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0207 0.0231
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0748 0.078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Brugia malayi cathepsin L-like precursor 0.0022 0.0144 0.015
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0171 0.0191
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0207 0.0231
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Onchocerca volvulus 0.0033 0.0284 0.0467
Loa Loa (eye worm) cytochrome b5 reductase 4 0.008 0.089 0.0994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0179 0.019
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0235 0.0482
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.1134 0.1215
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.6017 0.6017
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0171 0.0138
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0125 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0284 0.0257
Schistosoma mansoni amine GPCR 0.0027 0.0207 0.0231
Onchocerca volvulus 0.0022 0.0144 0.0228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.125 0.1401
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.125 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.109 0.109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0078 0.0033
Brugia malayi PAS domain containing protein 0.0094 0.1075 0.1195
Echinococcus granulosus geminin 0.033 0.4118 0.4613
Trypanosoma brucei NADH-dependent fumarate reductase 0.008 0.089 0.0939
Leishmania major protein kinase, putative 0.0025 0.0175 0.0134
Echinococcus granulosus hypothetical protein 0.0027 0.0207 0.0231
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.008 0.089 0.0939
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0078 0.0087
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0171 0.0266
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0175 0.0142
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni amine GPCR 0.0027 0.0207 0.0231
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0125 0.0006
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0166 0.0166
Onchocerca volvulus 0.0027 0.0207 0.0335
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0027 0.0207 0.0231
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Onchocerca volvulus 0.044 0.553 0.9385
Loa Loa (eye worm) hypothetical protein 0.0025 0.0175 0.0193
Loa Loa (eye worm) hypothetical protein 0.002 0.0121 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Leishmania major cathepsin L-like protease 0.0033 0.0284 0.0257
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Onchocerca volvulus 0.0027 0.0207 0.0335
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0179 0.019
Leishmania major p-glycoprotein e 0.0021 0.0125 0.0078
Schistosoma mansoni multidrug resistance protein 0.0021 0.0125 0.014
Leishmania major NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Onchocerca volvulus 0.0028 0.0221 0.036
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.008 0.089 0.6979
Schistosoma mansoni hypothetical protein 0.0033 0.0285 0.0319
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0171 0.0129
Trypanosoma cruzi oxidoreductase-like protein, putative 0.008 0.089 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Schistosoma mansoni diflavin oxidoreductase 0.0349 0.4358 0.4882
Echinococcus multilocularis serotonin receptor 0.0027 0.0207 0.0207
Loa Loa (eye worm) diaphorase 0.008 0.089 0.0994
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.125 0.3608
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0179 0.02
Onchocerca volvulus 0.0033 0.0284 0.0467
Echinococcus multilocularis cytochrome b5 reductase 4 0.008 0.089 0.089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0179 0.02
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.001 0.0008
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0284 0.0257
Mycobacterium tuberculosis Probable oxidoreductase 0.008 0.089 0.6979
Giardia lamblia ABC transporter, putative 0.0021 0.0125 0.0006
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0171 0.0191
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0207 0.0231
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0175 0.0134
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0179 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0207 0.0207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0179 0.02
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0703 0.8927 0.8927
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0431 0.0482
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0175 0.0142
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0207 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0179 0.0197
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0207 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0179 0.0179
Schistosoma mansoni neuropeptide receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0056 0.006
Loa Loa (eye worm) DR-78 0.0012 0.001 0.0008
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0125 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.125 0.1354
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.109 0.1221
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0235 0.0121
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0171 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0207 0.0231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0174 0.0133
Echinococcus granulosus orexin receptor type 2 0.0027 0.0207 0.0231
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.008 0.089 0.0987
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0174 0.0273
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0626 0.0701
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0125 0.0078
Trypanosoma cruzi oxidoreductase-protein, putative 0.008 0.089 0.0939
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0207 0.0207
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0171 0.0191
Echinococcus granulosus cytochrome b5 reductase 4 0.008 0.089 0.0996
Schistosoma mansoni hypothetical protein 0.0039 0.0368 0.0412
Trypanosoma brucei p-glycoprotein 0.0021 0.0125 0.0078
Echinococcus granulosus methionine synthase reductase 0.0434 0.5458 0.6114
Onchocerca volvulus 0.0033 0.0284 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0179 0.0179
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0207 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0207 0.0228
Entamoeba histolytica hypothetical protein 0.0021 0.0125 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0175 0.0134
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0171 0.0171
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) hypoxia-induced factor 1 0.0292 0.3625 0.4058
Onchocerca volvulus 0.0027 0.0207 0.0335
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0171 0.0138
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0171 0.0171
Brugia malayi hypothetical protein 0.0043 0.0419 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0235 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0387 0.0381
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0191
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0207 0.0228
Plasmodium vivax SET domain protein, putative 0.0059 0.0626 0.0642
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0207 0.0207
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1352 0.1512
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0207 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.125 0.1398
Leishmania major pentamidine resistance protein 1 0.0021 0.0125 0.0078
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0171 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Onchocerca volvulus 0.0033 0.0284 0.0467
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Onchocerca volvulus 0.0027 0.0207 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0144 0.0107
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.125 0.1346
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0475 0.5989 0.6708
Onchocerca volvulus 0.0233 0.2869 0.4861
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0188
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0703 0.8927 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0078 0.0025
Schistosoma mansoni cytochrome B5 0.008 0.089 0.0996
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.001 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.001 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.125 0.3608
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0179 0.0197
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0419 0.0469
Trichomonas vaginalis taga, putative 0.0024 0.0171 0.0138
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0235 0.021
Echinococcus granulosus neuropeptide receptor 0.0027 0.0207 0.0231
Leishmania major p450 reductase, putative 0.0703 0.8927 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.001 0.0011
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0125 0.0137
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0235 0.0415
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0431 0.0472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Brugia malayi flavodoxin family protein 0.0269 0.3327 0.3721
Schistosoma mansoni hypothetical protein 0.0043 0.0419 0.0469
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0703 0.8927 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0269 0.3327 0.3688
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0175 0.0134
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0387 0.0434
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0056 0.0056
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0316
Loa Loa (eye worm) flavodoxin family protein 0.0269 0.3327 0.3725
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0125 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) cysteine protease 0.0033 0.0284 0.0316
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0207 0.0231
Schistosoma mansoni zinc finger protein 0.0012 0.001 0.0011
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni aryl hydrocarbon receptor 0.0094 0.1075 0.1205
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0179 0.0197
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.001 0.0011
Trichomonas vaginalis abcb9, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0175 0.0193
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0174 0.0133
Onchocerca volvulus 0.0025 0.0175 0.0281
Schistosoma mansoni opsin-like receptor 0.0027 0.0207 0.0231
Schistosoma mansoni adenoreceptor 0.0027 0.0207 0.0231
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.001 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0179 0.02
Trichomonas vaginalis set domain proteins, putative 0.0468 0.5891 0.6581
Echinococcus multilocularis tumor protein p63 0.0328 0.4084 0.4084
Entamoeba histolytica hypothetical protein 0.0043 0.0419 0.105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0284 0.0257
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0387 0.0387
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.125 0.1398
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0536 0.0598
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0207 0.0231
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0284 0.0257
Plasmodium vivax flavodoxin domain containing protein 0.0623 0.7896 0.8838
Entamoeba histolytica hypothetical protein 0.0043 0.0419 0.105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0179 0.02
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Schistosoma mansoni multidrug resistance protein 0.0021 0.0125 0.014
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0207 0.0231
Schistosoma mansoni neuropeptide receptor 0.0027 0.0207 0.0231
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0269 0.3327 0.3688
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0284 0.0319
Leishmania major protein kinase, putative 0.0025 0.0175 0.0134
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0284 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Echinococcus granulosus serotonin receptor 0.0027 0.0207 0.0231
Plasmodium vivax hypothetical protein, conserved 0.0269 0.3327 0.3688
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0269 0.3327 0.3693
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0532
Leishmania major cytochrome-b5 reductase, putative 0.008 0.089 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0078 0.0033
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0171 0.0286
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0174 0.0133
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0207 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0179 0.0287
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Brugia malayi sulfakinin receptor protein 0.0027 0.0207 0.0221
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0125 0.0145
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0207 0.0231
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0078 0.0025
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0171 0.0138
Brugia malayi nuclear receptor NHR-88 0.0025 0.0179 0.019
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0207 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0179 0.019
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0703 0.8927 1
Brugia malayi hypothetical protein 0.044 0.553 0.619
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0175 0.0008
Brugia malayi Cathepsin L-like precursor 0.0022 0.0144 0.015
Echinococcus multilocularis transcription factor btf3 0.0069 0.0748 0.0748
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.134 0.1448
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0207 0.0231
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0626 0.0701
Brugia malayi Pax transcription factor protein 2 0.0233 0.2869 0.3206
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0171 0.0171
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0125 0.014
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0207 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1618 0.1813
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0179 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0179 0.019
Brugia malayi CHE-14 protein 0.0041 0.0387 0.0423
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0207 0.0228
Leishmania major NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0207 0.0231
Echinococcus granulosus cpg binding protein 0.003 0.0242 0.0271
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0207 0.0221
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0175 0.0142
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0078 0.0077
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0207 0.0207
Loa Loa (eye worm) FAD binding domain-containing protein 0.0434 0.5458 0.6113
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0028 0.0031
Leishmania major reductase, putative 0.008 0.089 0.0939
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0056 0.0056
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0171 0.0138
Brugia malayi 6-phosphofructokinase 0.0108 0.1255 0.1396
Onchocerca volvulus 0.0027 0.0207 0.0335
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0207 0.0221
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0078 0.0025
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.008 0.089 0.0989
Onchocerca volvulus 0.0024 0.0171 0.0274
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0179 0.019
Echinococcus granulosus lamin 0.0053 0.0536 0.0601
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0703 0.8927 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.006
Brugia malayi putative neuropeptide receptor 0.0027 0.0207 0.0221
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0284 0.0467
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0056 0.006
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.125 1
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0284 0.0467
Brugia malayi hypothetical protein 0.0024 0.0174 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0179 0.02
Trypanosoma cruzi p450 reductase, putative 0.0703 0.8927 1
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0078 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0222 0.0238
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Plasmodium vivax vivapain-2 0.0033 0.0284 0.0257
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Brugia malayi MH2 domain containing protein 0.0116 0.1352 0.1505
Brugia malayi AKH receptor 0.0027 0.0207 0.0221
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0235 0.0415
Trichomonas vaginalis sulfite reductase, putative 0.0703 0.8927 1
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.044 0.553 0.6193
Loa Loa (eye worm) ctsf protein 0.0033 0.0284 0.0316
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0703 0.8927 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0056 0.0052
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0125 0.0006
Brugia malayi Serotonin receptor 0.0027 0.0207 0.0221
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0207 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0626 0.0701
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0179 0.0197
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0179 0.02
Schistosoma mansoni amine GPCR 0.0027 0.0207 0.0231
Brugia malayi hypothetical protein 0.0013 0.0028 0.002
Schistosoma mansoni intermediate filament proteins 0.0053 0.0536 0.0601
Echinococcus granulosus neuropeptide receptor 0.0027 0.0207 0.0231
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0477 0.0534
Schistosoma mansoni opsin-like receptor 0.0027 0.0207 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Brugia malayi follicle stimulating hormone receptor 0.0475 0.5989 0.6705
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0207 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.001 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0056
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0235 0.0201
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0175 0.0142
Loa Loa (eye worm) hypothetical protein 0.012 0.1406 0.1572
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0179 0.019
Onchocerca volvulus 0.0027 0.0207 0.0335
Leishmania major cathepsin L-like protease 0.0033 0.0284 0.0257
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0179 0.019
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.001 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0179 0.02
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.6017 0.6741
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0207 0.0228
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.125 0.125
Echinococcus multilocularis cysteine protease 0.0033 0.0284 0.0284
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0207 0.0335
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0171 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Entamoeba histolytica type A flavoprotein, putative 0.0269 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.3941 0.4413
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0171 0.0138
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.008 0.089 0.1937
Schistosoma mansoni transcription factor btf3 0.0069 0.0748 0.0838
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0041 0.0387 0.0431
Schistosoma mansoni coup transcription factor 0.0025 0.0179 0.02
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0703 0.8927 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0235 0.0147
Brugia malayi 6-phosphofructokinase 0.0108 0.125 0.1391
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.008 0.089 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0235 0.0201
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0078 0.0025
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0125 0.0078
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Schistosoma mansoni hypothetical protein 0.0039 0.0368 0.0412
Onchocerca volvulus 0.0027 0.0207 0.0335
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0137
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.008 0.089 0.0996
Brugia malayi larval opioid receptor 0.0027 0.0207 0.0221
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0284 0.0319
Mycobacterium ulcerans flavodoxin oxidoreductase 0.008 0.089 0.016
Mycobacterium ulcerans oxidoreductase 0.008 0.089 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Plasmodium falciparum nitric oxide synthase, putative 0.0703 0.8927 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni neuropeptide receptor 0.0027 0.0207 0.0231
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0171 0.0129
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0171 0.0171
Brugia malayi Melatonin receptor type 1A 0.0027 0.0207 0.0221
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0207 0.0221
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Trichomonas vaginalis abcb9, putative 0.0024 0.0171 0.0138
Schistosoma mansoni lamin 0.0053 0.0536 0.0601
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0125 0.0145
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0207 0.0221
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0748 0.078
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0078 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0431 0.0482
Leishmania major cathepsin L-like protease 0.0033 0.0284 0.0257
Trypanosoma cruzi nitrate reductase, putative 0.008 0.089 0.0939
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0179 0.0179
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0078 0.0087
Treponema pallidum flavodoxin 0.0269 0.3327 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Schistosoma mansoni nuclear receptor 0.0012 0.001 0.0011
Echinococcus granulosus GPCR family 2 0.0015 0.0056 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0431 0.0431
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0207 0.0207
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0387 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0482 0.0537
Schistosoma mansoni hypothetical protein 0.033 0.4118 0.4613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0431 0.0482
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0703 0.8927 0.8927
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0748 0.078
Onchocerca volvulus 0.0027 0.0207 0.0335
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.001 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.0271
Echinococcus multilocularis sex peptide receptor 0.0027 0.0207 0.0207
Chlamydia trachomatis sulfite reductase 0.0434 0.5458 1
Schistosoma mansoni cytochrome P450 reductase 0.0703 0.8927 1
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0179 0.02
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0171 0.096
Brugia malayi G-protein coupled receptor 0.0027 0.0207 0.0221
Onchocerca volvulus 0.0053 0.0536 0.0896
Entamoeba histolytica type A flavoprotein, putative 0.0269 0.3327 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0207 0.0207
Leishmania major nitrate reductase, putative 0.008 0.089 0.0939
Mycobacterium ulcerans monooxygenase 0.008 0.089 0.016
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.109 0.1211
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Schistosoma mansoni hypothetical protein 0.0027 0.0207 0.0231
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0171 0.0191
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0703 0.8927 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0284 0.0635
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0056 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0748 0.0788
Giardia lamblia MRP-like ABC transporter 0.0021 0.0125 0.0006
Brugia malayi multidrug resistance related protein 1 0.0021 0.0125 0.0129
Entamoeba histolytica ABC transporter, putative 0.0021 0.0125 0.0145
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus somatostatin receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0188
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0419 0.0469
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0028 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0028 0.0028
Mycobacterium ulcerans flavodoxin reductase Hmp 0.008 0.089 0.016
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0125 0.0145
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0269 0.3327 0.3693
Loa Loa (eye worm) hypothetical protein 0.0059 0.0626 0.0698
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0175 0.0196
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0056 0.0063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0207 0.0207
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0269 0.3327 0.3693
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0186 0.0208
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.008 0.089 0.6979
Entamoeba histolytica type A flavoprotein, putative 0.0269 0.3327 1
Entamoeba histolytica P-glycoprotein-1 0.0024 0.0171 0.0286
Schistosoma mansoni nuclear receptor 0.0012 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0063
Echinococcus multilocularis GPCR, family 2 0.0015 0.0056 0.0056
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.008 0.089 0.2118
Echinococcus granulosus cysteine protease 0.0017 0.0078 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0179 0.0287
Schistosoma mansoni multidrug resistance protein 0.0021 0.0125 0.014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0626 0.1324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0431 0.0482
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Brugia malayi diaphorase 0.008 0.089 0.0987
Onchocerca volvulus 0.0027 0.0207 0.0335
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0144 0.0161
Echinococcus multilocularis protein patched 0.0041 0.0387 0.0387
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0235 0.0201
Onchocerca volvulus Huntingtin homolog 0.012 0.1406 0.2374
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0284 0.0308
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0434 0.5458 0.6114
Loa Loa (eye worm) hypothetical protein 0.012 0.1406 0.1572
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0207 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0748 0.0788
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0207 0.0231
Toxoplasma gondii flavodoxin domain-containing protein 0.0349 0.4358 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0269 0.3327 0.3688
Echinococcus granulosus lamin dm0 0.0053 0.0536 0.0601
Plasmodium vivax ferredoxin--NADP reductase, putative 0.008 0.089 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0175 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0175 0.0142
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.001 0.0011
Entamoeba histolytica hypothetical protein 0.0043 0.0419 0.105
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0186 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0284 0.0635
Brugia malayi hypoxia-induced factor 1 0.0292 0.3625 0.4054
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0179 0.0179
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0269 0.3327 0.3688
Entamoeba histolytica hypothetical protein 0.0069 0.0748 0.2062
Echinococcus multilocularis methionine synthase reductase 0.0434 0.5458 0.5458
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.001 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Entamoeba histolytica type A flavoprotein, putative 0.0269 0.3327 1
Schistosoma mansoni histamine h1 receptor 0.0027 0.0207 0.0231
Schistosoma mansoni hypothetical protein 0.0027 0.0207 0.0231
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0207 0.0231
Schistosoma mansoni hypothetical protein 0.0039 0.0368 0.0412
Brugia malayi nuclear receptor RXR 0.0013 0.0028 0.002
Echinococcus multilocularis geminin 0.033 0.4118 0.4118
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0166 0.0186
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0171 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Schistosoma mansoni biogenic amine receptor 0.0027 0.0207 0.0231
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0183
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.125 0.3284
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0171 0.0266
Schistosoma mansoni hypothetical protein 0.0101 0.1157 0.1296
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.001 0.001
Onchocerca volvulus 0.0027 0.0207 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0179 0.019
Brugia malayi GnHR receptor homolog 0.0027 0.0207 0.0221
Echinococcus granulosus allatostatin A receptor 0.0027 0.0207 0.0231
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0207 0.0231
Giardia lamblia Hypothetical protein 0.0623 0.7896 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0703 0.8927 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0626 0.0701
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0207 0.0207
Brugia malayi hypothetical protein 0.0013 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0174 0.0133
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0207 0.0207
Onchocerca volvulus 0.0027 0.0207 0.0335
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.125 0.3608
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0207 0.0231
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5025 0.5025
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.125 0.0601
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0125 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0078 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Brugia malayi ORL1-like opioid receptor 0.0027 0.0207 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0175 0.0142
Loa Loa (eye worm) hypothetical protein 0.005 0.0506 0.0564
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Leishmania major ABC-thiol transporter 0.0021 0.0125 0.0078
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Brugia malayi hypothetical protein 0.012 0.1406 0.1566
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0207 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0179 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Trichomonas vaginalis abcb9, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) hypothetical protein 0.0053 0.0536 0.0598
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.0171 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0626 0.0701
Brugia malayi neuropeptide F receptor 0.0027 0.0207 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0207 0.0231
Trypanosoma cruzi reductase, putative 0.008 0.089 0.0939
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0144 0.0202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.008 0.089 0.0939
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.125 0.1354
Schistosoma mansoni hypothetical protein 0.033 0.4118 0.4613
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0284 0.0257
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0175 0.0142
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0179 0.02
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0171 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Brugia malayi ABC transporter family protein 0.0024 0.0171 0.0181
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.125 0.1346
Trypanosoma brucei nitrate reductase, putative 0.008 0.089 0.0939
Echinococcus multilocularis musashi 0.0053 0.0536 0.0536
Schistosoma mansoni cpg binding protein 0.0028 0.0221 0.0248
Echinococcus multilocularis lamin dm0 0.0053 0.0536 0.0536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0179 0.0179
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0207 0.0231
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0207 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Echinococcus multilocularis lamin 0.0053 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0179 0.02
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0574 0.1203
Brugia malayi ecdysteroid receptor 0.0025 0.0179 0.019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0028 0.0031
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0175 0.0142
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.008 0.089 0.089
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0207 0.0207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0179 0.02
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0207 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0431 0.048
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0052 0.0524 0.0584
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1481 0.1606
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.516 0.5779
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0419 0.0419
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.061 0.0673
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0536 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0179 0.019
Brugia malayi G protein-coupled receptor 0.0027 0.0207 0.0221
Onchocerca volvulus 0.0059 0.0626 0.1048
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Schistosoma mansoni amine GPCR 0.0027 0.0207 0.0231
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0284 0.0316
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0748 0.078
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0284 0.0266
Onchocerca volvulus 0.0027 0.0207 0.0335
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0125 0.0078
Onchocerca volvulus 0.0033 0.0284 0.0467
Brugia malayi hypothetical protein 0.0016 0.0062 0.0059
Leishmania major cathepsin L-like protease 0.0033 0.0284 0.0257
Echinococcus multilocularis protein dispatched 1 0.0047 0.0462 0.0462
Trypanosoma cruzi p450 reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0656 0.0735
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Brugia malayi flavodoxin family protein 0.0703 0.8927 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0192
Entamoeba histolytica type A flavoprotein, putative 0.0269 0.3327 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0207 0.0231
Brugia malayi phosphofructokinase 0.0108 0.125 0.1391
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0207 0.0207
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.001 0.001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0171 0.0171
Onchocerca volvulus 0.0025 0.0179 0.0287
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.059 0.0661
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus multilocularis somatostatin receptor 0.0027 0.0207 0.0207
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0175 0.0134
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0269 0.3327 0.3693
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Echinococcus granulosus cytochrome b5 reductase 4 0.008 0.089 0.0996
Echinococcus granulosus sex peptide receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0179 0.0197
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0175 0.0134
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Echinococcus granulosus single minded 2 0.007 0.0759 0.085
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0175 0.0142
Onchocerca volvulus Huntingtin homolog 0.012 0.1406 0.2374
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.125 0.1346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0144 0.0107
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni lamin 0.0053 0.0536 0.0601
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0125 0.0078
Leishmania major cathepsin L-like protease 0.0126 0.1481 0.1606
Schistosoma mansoni nuclear hormone receptor 0.0012 0.001 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Brugia malayi hypothetical protein 0.0316 0.3941 0.4408
Echinococcus granulosus transcription factor btf3 0.0069 0.0748 0.0838
Brugia malayi Serotonin receptor 0.0027 0.0207 0.0221
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0284 0.0319
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0125 0.0145
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0387 0.0434
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0284 0.0316
Echinococcus multilocularis transfer RNA-Lys 0.007 0.0759 0.0759
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0063
Onchocerca volvulus 0.0027 0.0207 0.0335
Loa Loa (eye worm) hypothetical protein 0.0286 0.3542 0.3966
Brugia malayi multidrug resistance protein 3 0.0024 0.0171 0.0181
Leishmania major basic transcription factor 3a, putative 0.0069 0.0748 0.078
Leishmania major NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Schistosoma mansoni multidrug resistance protein 0.0024 0.0171 0.0191
Toxoplasma gondii cathepsin CPL 0.0033 0.0284 0.0531
Onchocerca volvulus 0.0027 0.0207 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0179 0.019
Brugia malayi FAD binding domain containing protein 0.0434 0.5458 0.611
Echinococcus granulosus cathepsin l1 0.0022 0.0144 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Echinococcus multilocularis cpg binding protein 0.003 0.0242 0.0242
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0207 0.0231
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0285 0.0309
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0703 0.8927 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0179 0.02
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0179 0.02
Schistosoma mansoni multidrug resistance protein 0.0024 0.0171 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0703 0.8927 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0207 0.0231
Schistosoma mansoni smdr2 0.0024 0.0171 0.0191
Echinococcus multilocularis expressed conserved protein 0.009 0.1015 0.1015
Brugia malayi beta-NAC-like protein 0.0069 0.0748 0.0828
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0171 0.0171
Echinococcus multilocularis serotonin receptor 0.0027 0.0207 0.0207
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0482 0.053
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0207 0.0231
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0207 0.0231
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0207 0.0231
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Leishmania major hypothetical protein, conserved 0.0024 0.0174 0.0133
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0179 0.019
Schistosoma mansoni myosin xvIII 0.0027 0.0207 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0171 0.0286
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0171 0.0286
Plasmodium falciparum ferredoxin--NADP reductase 0.008 0.089 0.0939
Trypanosoma brucei multidrug resistance protein E 0.0021 0.0125 0.0078
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0748 0.1608
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0431 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0179 0.019
Onchocerca volvulus 0.0468 0.5891 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.001 0.0011
Onchocerca volvulus 0.0033 0.0284 0.0467
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0207 0.0207
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0703 0.8927 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0125 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0056 0.0056
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0171 0.0191
Schistosoma mansoni hypothetical protein 0.0039 0.0368 0.0412
Loa Loa (eye worm) phosphofructokinase 0.0108 0.125 0.1398
Brugia malayi Dopamine receptor protein 2 0.0027 0.0207 0.0221
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0144 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0179 0.0197
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0207 0.0207
Echinococcus granulosus fmrfamide receptor 0.0027 0.0207 0.0231
Echinococcus granulosus microtubule associated protein 2 0.0676 0.8575 0.9605
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0207 0.0207
Trypanosoma brucei RNA helicase, putative 0.0101 0.1157 0.1241
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0174 0.0133
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0207 0.0207
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0235 0.0201
Schistosoma mansoni survival motor neuron protein 0.0058 0.061 0.0683
Brugia malayi isocitrate dehydrogenase 0.0015 0.0056 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0207 0.0231
Leishmania major cathepsin L-like protease 0.0126 0.1481 0.1606
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0235 0.0121
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0207 0.0207
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0207 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0056 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1352 0.1512
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0207 0.0207
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0171 0.0138
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0174 0.0133
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0703 0.8927 1
Brugia malayi steroid hormone receptor 0.0025 0.0179 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Brugia malayi intermediate filament protein 0.0053 0.0536 0.0591
Schistosoma mansoni nuclear hormone receptor 0.0012 0.001 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0179 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0078 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0078 0.0077
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0179 0.02
Mycobacterium ulcerans electron transfer protein FdxB 0.008 0.089 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Mycobacterium ulcerans oxygenase 0.008 0.089 0.016
Leishmania major p-glycoprotein 0.0024 0.0171 0.0129
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0179 0.02
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0175 0.0175
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0175 0.0196
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0207 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.125 0.1354
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0137
Schistosoma mansoni neuropeptide receptor 0.0027 0.0207 0.0231
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0056 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0626 0.0626
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0175 0.0175
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0626 0.0626
Brugia malayi nuclear hormone receptor 0.0025 0.0179 0.019
Leishmania major oxidoreductase-like protein 0.008 0.089 0.0939
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0158
Onchocerca volvulus 0.007 0.0759 0.1274
Echinococcus multilocularis Protein lozenge 0.0055 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni NADH-cytochrome B5 reductase 0.008 0.089 0.0996
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0125 0.0145
Loa Loa (eye worm) hypothetical protein 0.044 0.553 0.6193
Brugia malayi bHLH-PAS transcription factor 0.007 0.0759 0.0841
Schistosoma mansoni opsin-like receptor 0.0027 0.0207 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0284 0.0266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0482 0.053
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Schistosoma mansoni NADPH flavin oxidoreductase 0.0354 0.4427 0.4959
Schistosoma mansoni biogenic amine receptor 0.0027 0.0207 0.0231
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0207 0.0231
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus expressed conserved protein 0.009 0.1015 0.1137
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0028 0.002
Brugia malayi Cathepsin L-like precursor 0.0022 0.0144 0.015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0179 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1481 0.1606
Echinococcus granulosus cathepsin L 0.0017 0.0078 0.0087
Onchocerca volvulus 0.0033 0.0284 0.0467
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1109 0.1242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0179 0.019
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0748 0.078
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0179 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0179 0.02
Brugia malayi neuropeptide F receptor 0.0027 0.0207 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Schistosoma mansoni multidrug resistance protein 0.0024 0.0171 0.0191
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0056 0.0056
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0207 0.0221
Leishmania major NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0171 0.0188
Loa Loa (eye worm) runx1 0.0055 0.057 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0179 0.019
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0207 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0285 0.0316
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0078 0.0087
Schistosoma mansoni amine GPCR 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0179 0.0197
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0207 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0207 0.0207
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0207 0.0231
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.0271
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0171 0.0138
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0179 0.02
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0207 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Brugia malayi Pre-SET motif family protein 0.0411 0.516 0.5776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0284 0.0266
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0207 0.0207
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0125 0.0078
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0125 0.0125
Loa Loa (eye worm) FAD binding domain-containing protein 0.0703 0.8927 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0008
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0049 0.0054
Trypanosoma brucei NADH-dependent fumarate reductase 0.008 0.089 0.0939
Brugia malayi RE15519p 0.0027 0.0207 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0179 0.019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0125 0.0125
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0269 0.3327 0.3688
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3542 0.3968
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.1481 0.1606
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0063
Brugia malayi hypothetical protein 0.0027 0.0207 0.0221
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0191
Echinococcus granulosus neuropeptide s receptor 0.0477 0.6017 0.6741
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0207 0.0228
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0536 0.0591
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0158
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0623 0.7896 0.8839
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.6017 0.6017
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.125 0.1401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0063
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0207 0.0228
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0049 0.0054
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0222 0.0245
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.008 0.089 0.1359
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0221 0.0245
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0125 0.016
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0207 0.0231
Echinococcus granulosus tumor protein p63 0.0328 0.4084 0.4575
Loa Loa (eye worm) hypothetical protein 0.0025 0.0186 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Mycobacterium tuberculosis Probable monooxygenase 0.008 0.089 0.6979
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0207 0.0231
Plasmodium vivax vivapain-2 0.0033 0.0284 0.0257
Schistosoma mansoni hypothetical protein 0.0027 0.0207 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.125 0.1354
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0171 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0179 0.019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0207 0.0221
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0171 0.0191
Onchocerca volvulus 0.0027 0.0207 0.0335
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.008 0.089 0.0939
Echinococcus granulosus g protein coupled receptor 0.0027 0.0207 0.0231
Schistosoma mansoni single-minded 0.0094 0.1075 0.1205
Onchocerca volvulus 0.0053 0.0536 0.0896
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0748 0.0835
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.8575 0.8575
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.001 0.0011
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.008 0.089 0.0939
Mycobacterium tuberculosis Possible oxygenase 0.008 0.089 0.6979
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0207 0.0231
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0748 0.0788
Echinococcus granulosus dnaJ subfamily B 0.04 0.5025 0.5629
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Schistosoma mansoni lozenge 0.0055 0.057 0.0639
Echinococcus granulosus g protein coupled receptor 0.0027 0.0207 0.0231
Leishmania major NADH-dependent fumarate reductase-like protein 0.008 0.089 0.0939
Schistosoma mansoni hypothetical protein 0.04 0.5025 0.5629
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0095 0.109 0.1218
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0171 0.0286
Leishmania major cathepsin L-like protease 0.0033 0.0284 0.0257
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.008 0.089 0.0939
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2869 0.3211
Echinococcus granulosus intermediate filament protein 0.0053 0.0536 0.0601
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0235 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0431 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1481 0.1606
Toxoplasma gondii flavodoxin domain-containing protein 0.0349 0.4358 1
Onchocerca volvulus 0.008 0.089 0.1496
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0228
Onchocerca volvulus 0.0027 0.0207 0.0335
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0125 0.0078
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0175 0.0142
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0207 0.0231
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0207 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0284 0.0266
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0269 0.3327 0.3688
Schistosoma mansoni patched 1 0.0041 0.0387 0.0434
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0171 0.0138
Brugia malayi Dopamine receptor 0.0027 0.0207 0.0221
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0482 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0207 0.0207
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0171 0.0171
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0284 0.0284
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0207 0.0335
Loa Loa (eye worm) fibroinase 0.0033 0.0284 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0207 0.0231
Leishmania major hypothetical protein, conserved 0.0269 0.3327 0.3688
Brugia malayi Cathepsin L-like precursor 0.0033 0.0284 0.0308
Brugia malayi CXXC zinc finger family protein 0.0028 0.0221 0.0238
Plasmodium vivax unspecified product 0.0017 0.0078 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0207 0.0231
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0175 0.0134
Schistosoma mansoni hypothetical protein 0.0058 0.061 0.0683
Echinococcus multilocularis cathepsin L 0.0017 0.0078 0.0078
Brugia malayi Dopamine receptor protein 1 0.0027 0.0207 0.0221
Leishmania major cytochrome P450 reductase, putative 0.0623 0.7896 0.8838
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0207 0.0228
Onchocerca volvulus 0.0027 0.0207 0.0335
Echinococcus multilocularis cysteine protease 0.0033 0.0284 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0284 0.0635
Onchocerca volvulus 0.0058 0.061 0.1021
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0748 0.2062
Entamoeba histolytica P-glycoprotein-5 0.0024 0.0171 0.0286
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0028 0.0031
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3542 0.3542
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0175 0.0134
Plasmodium vivax vivapain-1 0.0017 0.0078 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0056 0.0056
Trypanosoma brucei oxidoreductase-protein, putative 0.008 0.089 0.0939

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.