Detailed information for compound 1358735

Basic information

Technical information
  • TDR Targets ID: 1358735
  • Name: 1-[6-[3-[4-(4-methoxyphenyl)piperazine-1-carb onyl]piperidin-1-yl]sulfonyl-3,4-dihydro-2H-q uinolin-1-yl]ethanone
  • MW: 540.674 | Formula: C28H36N4O5S
  • H donors: 0 H acceptors: 4 LogP: 2.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)C1CCCN(C1)S(=O)(=O)c1ccc2c(c1)CCCN2C(=O)C
  • InChi: 1S/C28H36N4O5S/c1-21(33)32-14-4-5-22-19-26(11-12-27(22)32)38(35,36)31-13-3-6-23(20-31)28(34)30-17-15-29(16-18-30)24-7-9-25(37-2)10-8-24/h7-12,19,23H,3-6,13-18,20H2,1-2H3
  • InChiKey: UZHIXSQNACMUKU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[6-[[3-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-1-piperidyl]sulfonyl]-3,4-dihydro-2H-quinolin-1-yl]ethanone
  • 1-[6-[[3-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-1-piperidinyl]sulfonyl]-3,4-dihydro-2H-quinolin-1-yl]ethanone
  • 1-[6-[3-[4-(4-methoxyphenyl)piperazin-1-yl]carbonylpiperidin-1-yl]sulfonyl-3,4-dihydro-2H-quinolin-1-yl]ethanone
  • G855-6094
  • NCGC00135610-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Onchocerca volvulus 0.0106 0.0665 0.5467
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.007 0.0063
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0037 0.0172 0.0439
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0106 0.0665 0.0665
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0665 0.0651
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0206 0.0526
Schistosoma mansoni neuropeptide receptor 0.0106 0.0665 0.0665
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0104 0.0265
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0446 0.1137
Schistosoma mansoni alpha-1 adrenergic receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Onchocerca volvulus 0.0037 0.0172 0.1417
Loa Loa (eye worm) norepinephrine transporter 0.0182 0.1217 0.2079
Echinococcus granulosus neuropeptides capa receptor 0.0106 0.0665 0.0665
Echinococcus granulosus neuropeptide receptor A26 0.0106 0.0665 0.0665
Toxoplasma gondii ion channel protein 0.0037 0.0172 0.316
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Brugia malayi hypothetical protein 0.0037 0.0172 0.0439
Brugia malayi MH2 domain containing protein 0.0025 0.0084 0.0215
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0037 0.0172 0.0439
Loa Loa (eye worm) nuclear factor I 0.0014 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0294 0.0294
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.032
Echinococcus multilocularis G-protein coupled receptor, putative 0.0106 0.0665 0.0651
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Loa Loa (eye worm) serotonin transporter b 0.0182 0.1217 0.2079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Brugia malayi MH1 domain containing protein 0.0025 0.0084 0.0215
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0122 0.0783 0.1337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0134 0.0341
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0184 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0106 0.0665 0.0665
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Entamoeba histolytica hypothetical protein 0.01 0.062 0.2557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0214 0.0544
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0037 0.0172 0.0439
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.0123
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.001 0.0027
Schistosoma mansoni histamine h1 receptor 0.0106 0.0665 0.0665
Onchocerca volvulus 0.0106 0.0665 0.5467
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.016 0.0407
Loa Loa (eye worm) TYRA-2 protein 0.0106 0.0665 0.1137
Brugia malayi hypothetical protein 0.0036 0.0161 0.041
Echinococcus multilocularis neuropeptide Y receptor 0.0106 0.0665 0.0651
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0106 0.0665 0.1695
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0261 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0152 0.0998 0.0998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus granulosus tumor protein p63 0.0408 0.2844 0.2844
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0236 0.0602
Leishmania major cathepsin L-like protease 0.0077 0.0458 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0294 0.613
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Brugia malayi sulfakinin receptor protein 0.0106 0.0665 0.1695
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Brugia malayi Serotonin receptor 0.0106 0.0665 0.1695
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0126 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0106 0.0665 0.0665
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0084 0.0084
Onchocerca volvulus 0.0037 0.0172 0.1417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.007 0.0074
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.007 0.0867
Toxoplasma gondii ABC1 family protein 0.0075 0.0446 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0037 0.0172 0.0439
Brugia malayi AKH receptor 0.0106 0.0665 0.1695
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0214 0.4251
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0221 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0283 0.0722
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0084 0.0069
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0037 0.0172 0.0439
Brugia malayi hypothetical protein 0.0031 0.0126 0.032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0106 0.0665 0.0651
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Mycobacterium tuberculosis Conserved protein 0.0075 0.0446 0.1202
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.3376 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0283 0.5886
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0446 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0082
Onchocerca volvulus 0.002 0.0048 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0294 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Onchocerca volvulus 0.0075 0.0446 0.3667
Onchocerca volvulus 0.0031 0.0126 0.1032
Onchocerca volvulus 0.0031 0.0126 0.1032
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0446 0.1137
Onchocerca volvulus 0.0083 0.05 0.4107
Schistosoma mansoni calcium-activated potassium channel 0.0826 0.5854 0.5854
Onchocerca volvulus 0.0031 0.0126 0.1032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Onchocerca volvulus 0.0106 0.0665 0.5467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0086
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0037 0.0172 0.038
Schistosoma mansoni adenoreceptor 0.0106 0.0665 0.0665
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0665 0.0665
Echinococcus multilocularis potassium channel subfamily K 0.0037 0.0172 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0046 0.0289
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0037 0.0172 0.0294
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0106 0.0665 0.1137
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0106 0.0665 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0215
Plasmodium vivax potassium channel, putative 0.0037 0.0172 0.316
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0048 0.0082
Echinococcus multilocularis sex peptide receptor 0.0106 0.0665 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Loa Loa (eye worm) acetyltransferase 0.015 0.0986 0.1684
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0106 0.0665 0.0665
Echinococcus granulosus g-protein coupled receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0172 0.0439
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0126 0.199
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0106 0.0665 0.1137
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0126 0.0126
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0294 0.613
Onchocerca volvulus 0.0037 0.0172 0.1417
Echinococcus granulosus G protein coupled receptor 139 0.0106 0.0665 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.029
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.112 0.462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0037 0.0172 0.0439
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0126 0.0126
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0194 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0113 0.0289
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0037 0.0172 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Echinococcus granulosus g protein coupled receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.199
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0016
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0194 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0106 0.0665 0.0651
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0037 0.0172 0.3271
Schistosoma mansoni hypothetical protein 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0178
Brugia malayi RE15519p 0.0106 0.0665 0.1695
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0182 0.1217 0.1217
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Onchocerca volvulus 0.0106 0.0665 0.5467
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0106 0.0665 0.0665
Brugia malayi ORL1-like opioid receptor 0.0106 0.0665 0.1695
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0084 0.0084
Onchocerca volvulus 0.0106 0.0665 0.5467
Leishmania major hypothetical protein, conserved 0.0037 0.0172 0.3271
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.1826 0.4653
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Schistosoma mansoni hypothetical protein 0.0826 0.5854 0.5854
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.0032
Echinococcus granulosus neuropeptides capa receptor 0.0106 0.0665 0.0665
Onchocerca volvulus 0.006 0.0333 0.2736
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Onchocerca volvulus 0.0037 0.0172 0.1417
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0184 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.0199
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0283 0.5886
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0221 0.0563
Onchocerca volvulus 0.0037 0.0172 0.1417
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.05 0.0485
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0665 0.0665
Onchocerca volvulus 0.0106 0.0665 0.5467
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0343
Trichomonas vaginalis esterase, putative 0.0075 0.0446 0.1137
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0283 0.0998
Onchocerca volvulus 0.0075 0.0446 0.3667
Echinococcus granulosus 7tm_1 domain containing protein 0.0106 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Onchocerca volvulus 0.002 0.0048 0.0396
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0283 0.5886
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0283 0.5886
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0446 0.1202
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0283 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis Smad4 0.0025 0.0084 0.0069
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0037 0.0172 0.0439
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0084 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.1086 0.1072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Schistosoma mansoni hypothetical protein 0.0701 0.4953 0.4953
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.041 0.8864
Onchocerca volvulus 0.0106 0.0665 0.5467
Echinococcus granulosus potassium channel subfamily K 8 0.0037 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0161 0.0145
Onchocerca volvulus 0.0106 0.0665 0.5467
Onchocerca volvulus Cathepsin L homolog 0.002 0.0048 0.0396
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0087 0.1269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0019
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0283 0.5886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0294 0.0748
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0046 0.0189
Schistosoma mansoni hypothetical protein 0.0701 0.4953 0.4953
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0104 0.0178
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0037 0.0172 0.0439
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.05 0.1273
Echinococcus multilocularis allatostatin A receptor 0.0106 0.0665 0.0651
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0106 0.0665 0.0665
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0446 0.1032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0037 0.0172 0.1417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0294 0.0748
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0343
Leishmania major hypothetical protein, conserved 0.0037 0.0172 0.3271
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.05 0.05
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0665 0.0665
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0106 0.0665 0.1695
Mycobacterium leprae Probable lipase LipE 0.0075 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0252
Echinococcus multilocularis neuropeptides capa receptor 0.0106 0.0665 0.0651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0446 0.1137
Echinococcus granulosus Smad4 0.0025 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0665 0.0651
Brugia malayi Serotonin receptor 0.0106 0.0665 0.1695
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0037 0.0172 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1233 0.3141
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.062 0.2557
Echinococcus granulosus cathepsin l1 0.002 0.0048 0.0048
Brugia malayi glutaminase DH11.1 0.0558 0.3925 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0037 0.0172 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0126 0.011
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0283 0.0722
Echinococcus granulosus neuropeptide s receptor 0.0106 0.0665 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0037 0.0172 0.0439
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.0046
Echinococcus multilocularis twik family of potassium channels 0.0037 0.0172 0.0157
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Schistosoma mansoni amine GPCR 0.0106 0.0665 0.0665
Echinococcus granulosus g protein coupled receptor 0.0106 0.0665 0.0665
Plasmodium vivax potassium channel, putative 0.0037 0.0172 0.316
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.2571 0.4393
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.029
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0048 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.029
Echinococcus multilocularis g-protein coupled receptor 0.0106 0.0665 0.0651
Brugia malayi G-protein coupled receptor 0.0106 0.0665 0.1695
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.0032
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0294 0.0294
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0037 0.0172 0.0172
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0283 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1086 0.1086
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0925 0.158
Toxoplasma gondii cathepsin CPL 0.002 0.0048 0.0057
Schistosoma mansoni hypothetical protein 0.0036 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.029
Onchocerca volvulus Cathepsin L homolog 0.002 0.0048 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Brugia malayi Tachykinin-like peptides receptor 99D 0.0106 0.0665 0.1695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0113 0.0289
Echinococcus granulosus somatostatin receptor 0.0106 0.0665 0.0665
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0998 0.0984
Leishmania major cathepsin L-like protease 0.0077 0.0458 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0126 0.032
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.0664
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.0032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0294 0.0748
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0037 0.0172 0.0439
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0046 0.0289
Brugia malayi Dopamine receptor protein 2 0.0106 0.0665 0.1695
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0106 0.0665 0.1137
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Schistosoma mansoni sodium/chloride dependent transporter 0.0182 0.1217 0.1217
Schistosoma mansoni opsin-like receptor 0.0106 0.0665 0.0665
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0283 0.0283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Echinococcus multilocularis calcium activated potassium channel variant 0.0037 0.0172 0.0157
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0126 0.011
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0283 0.0268
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.004
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0446 1
Brugia malayi G-protein coupled receptor 0.0106 0.0665 0.1695
Onchocerca volvulus Huntingtin homolog 0.0122 0.0783 0.6431
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0221 0.4375
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0106 0.0665 0.0651
Brugia malayi neuropeptide F receptor 0.0106 0.0665 0.1695
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0106 0.0665 0.0651
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0048 0.0123
Echinococcus multilocularis lamin dm0 0.0028 0.0104 0.0088
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Brugia malayi beta-lactamase family protein 0.0075 0.0446 0.1137
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0283 0.5886
Echinococcus multilocularis fmrfamide receptor 0.0106 0.0665 0.0651
Echinococcus multilocularis serotonin transporter 0.0182 0.1217 0.1203
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0106 0.0665 0.1695
Echinococcus granulosus potassium channel subfamily K 0.0037 0.0172 0.0172
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.007 0.0613
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0147 0.0375
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0221 0.4375
Echinococcus multilocularis neuropeptide receptor 0.0106 0.0665 0.0651
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0446 0.1032
Schistosoma mansoni biogenic amine receptor 0.0106 0.0665 0.0665
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0126 0.5362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Trypanosoma cruzi ion transport protein, putative 0.0037 0.0172 0.3271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Loa Loa (eye worm) neuropeptide F receptor 0.0106 0.0665 0.1137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0046 0.0289
Schistosoma mansoni amine GPCR 0.0106 0.0665 0.0665
Echinococcus multilocularis G protein coupled receptor 139 0.0106 0.0665 0.0651
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0446 0.0446
Brugia malayi G protein-coupled receptor F59B2.13 0.0106 0.0665 0.1695
Onchocerca volvulus 0.0106 0.0665 0.5467
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0294 0.613
Loa Loa (eye worm) hypothetical protein 0.006 0.0333 0.0569
Toxoplasma gondii ion channel protein 0.0037 0.0172 0.316
Brugia malayi beta-lactamase 0.0075 0.0446 0.1137
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0221 0.4375
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0106 0.0665 0.0651
Echinococcus granulosus tachykinin peptides receptor 99D 0.0106 0.0665 0.0665
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0316 0.0541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trypanosoma brucei protein kinase, putative 0.0053 0.0283 0.5886
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0065 0.0738
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Plasmodium vivax vivapain-2 0.002 0.0048 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0106 0.0665 0.1695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0037 0.0172 0.0711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.199
Echinococcus multilocularis neuropeptides capa receptor 0.0106 0.0665 0.0651
Echinococcus multilocularis somatostatin receptor 0.0106 0.0665 0.0651
Echinococcus granulosus 7TM GPCR rhodopsin 0.0106 0.0665 0.0665
Mycobacterium ulcerans beta-lactamase 0.0075 0.0446 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0136 0.0347
Echinococcus granulosus twik family of potassium channels 0.0037 0.0172 0.0172
Onchocerca volvulus 0.0106 0.0665 0.5467
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0261 0.0664
Echinococcus granulosus lamin 0.0028 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Schistosoma mansoni smad1 5 8 and 0.0025 0.0084 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0413 0.1052
Onchocerca volvulus Neuropeptide F receptor homolog 0.0106 0.0665 0.5467
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0172 0.3271
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0172 0.3271
Schistosoma mansoni biogenic amine receptor 0.0106 0.0665 0.0665
Onchocerca volvulus 0.0075 0.0446 0.3667
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Loa Loa (eye worm) melatonin receptor type 1A 0.0106 0.0665 0.1137
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0037 0.0172 0.3271
Echinococcus granulosus fmrfamide receptor 0.0106 0.0665 0.0665
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.032
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0446 0.0446
Echinococcus multilocularis smad 0.0025 0.0084 0.0069
Brugia malayi putative neuropeptide receptor NPR1 0.0106 0.0665 0.1695
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0339 0.7198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Onchocerca volvulus 0.002 0.0048 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0046 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Loa Loa (eye worm) hypothetical protein 0.0346 0.2394 0.4089
Leishmania major calcium/potassium channel (CAKC), putative 0.0037 0.0172 0.3271
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0294 0.1211
Echinococcus multilocularis neuropeptide FF receptor 2 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0037 0.0172 0.0157
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0037 0.0172 0.0439
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Brugia malayi Smad1 0.0025 0.0084 0.0215
Schistosoma mansoni neuropeptide receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Mycobacterium ulcerans hypothetical protein 0.0075 0.0446 0.1032
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0126 0.011
Leishmania major cathepsin L-like protease 0.0077 0.0458 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0446 0.9727
Onchocerca volvulus 0.002 0.0048 0.0396
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.0199
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.0664
Schistosoma mansoni opsin-like receptor 0.0106 0.0665 0.0665
Echinococcus granulosus lamin dm0 0.0028 0.0104 0.0104
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0413 0.1052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.016 0.0144
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0037 0.0172 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0214 0.0544
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.2571 0.4393
Schistosoma mansoni neuropeptide receptor 0.0106 0.0665 0.0665
Echinococcus granulosus alpha 1A adrenergic receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0048 0.0082
Brugia malayi larval opioid receptor 0.0106 0.0665 0.1695
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0446 0.1137
Echinococcus granulosus peptide allatostatin:somatostatin 0.0106 0.0665 0.0665
Loa Loa (eye worm) Smad1 0.0025 0.0084 0.0144
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0343
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0221 0.0563
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0925 0.0911
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0446 0.1202
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0084 0.0084
Loa Loa (eye worm) beta-lactamase 0.0075 0.0446 0.0762
Echinococcus granulosus potassium channel subfamily K 8 0.0037 0.0172 0.0172
Schistosoma mansoni microtubule-associated protein tau 0.1401 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Leishmania major ion transport protein-like protein 0.0037 0.0172 0.3271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.1217 0.2079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Echinococcus multilocularis musashi 0.0028 0.0104 0.0088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.5728 0.5721
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Onchocerca volvulus 0.002 0.0048 0.0396
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0037 0.0172 0.0157
Giardia lamblia DNA repair protein RAD52 0.035 0.2424 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0156 0.0398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0161 0.0161
Schistosoma mansoni neuropeptide F-like receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus granulosus twik family of potassium channels 0.0037 0.0172 0.0172
Echinococcus granulosus neuropeptide FF receptor 2 0.0106 0.0665 0.0665
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0283 0.0722
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0027
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.0046
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.199
Schistosoma mansoni amine GPCR 0.0106 0.0665 0.0665
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0194 0.0802
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.0171
Echinococcus multilocularis serotonin receptor 0.0106 0.0665 0.0651
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0048 0.0048
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0986 0.2512
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0182 0.1217 0.31
Loa Loa (eye worm) hypothetical protein 0.0169 0.112 0.1913
Onchocerca volvulus 0.002 0.0048 0.0396
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0048 0.0155
Brugia malayi follicle stimulating hormone receptor 0.0106 0.0665 0.1695
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0126 0.0126
Onchocerca volvulus 0.0106 0.0665 0.5467
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Onchocerca volvulus 0.0077 0.0459 0.3769
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0283 0.0283
Loa Loa (eye worm) neuropeptide F receptor 0.0106 0.0665 0.1137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0027
Schistosoma mansoni neuropeptide receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0665 0.0651
Echinococcus granulosus allatostatin A receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0182 0.1217 0.2079
Brugia malayi putative neuropeptide receptor 0.0106 0.0665 0.1695
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis neuropeptide receptor A26 0.0106 0.0665 0.0651
Onchocerca volvulus Cathepsin F homolog 0.002 0.0048 0.0396
Schistosoma mansoni neuropeptide f receptor 76f 0.0106 0.0665 0.0665
Toxoplasma gondii hypothetical protein 0.0031 0.0126 0.199
Trypanosoma cruzi ion transport protein, putative 0.0037 0.0172 0.3271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1233 0.3141
Schistosoma mansoni opsin-like receptor 0.0106 0.0665 0.0665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0136 0.0347
Schistosoma mansoni calcium-activated potassium channel 0.0731 0.517 0.517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0086
Mycobacterium ulcerans glutaminase 0.0558 0.3925 1
Brugia malayi hypothetical protein 0.0122 0.0783 0.1994
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0283 0.0722
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0925 0.0911
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0018
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0037 0.0172 0.3271
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.0117
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0048 0.0155
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0446 0.0431
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0126 0.011
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0129 0.0129
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0446 0.1202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0106 0.0665 0.0665
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.05 0.05
Trichomonas vaginalis glutaminase, putative 0.0558 0.3925 1
Echinococcus granulosus orexin receptor type 2 0.0106 0.0665 0.0665
Brugia malayi G protein-coupled receptor 0.0106 0.0665 0.1695
Onchocerca volvulus 0.0106 0.0665 0.5467
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0986 0.0972
Trypanosoma brucei calcium-activated potassium channel, putative 0.0037 0.0172 0.3271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0214 0.0544
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0446 0.9727
Echinococcus granulosus serotonin transporter 0.0182 0.1217 0.1217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0136 0.0347
Echinococcus multilocularis microtubule associated protein 2 0.1401 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) TWK-28 protein 0.0037 0.0172 0.0294
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Echinococcus multilocularis serotonin receptor 0.0106 0.0665 0.0651
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0106 0.0665 0.0651
Schistosoma mansoni lamin 0.0028 0.0104 0.0104
Schistosoma mansoni growth hormone secretagogue receptor 0.0106 0.0665 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0046 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) glutaminase 2 0.0558 0.3925 0.6705
Echinococcus multilocularis neuropeptide s receptor 0.0106 0.0665 0.0651
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0214 0.4251
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0283 0.0283
Mycobacterium ulcerans transmembrane cation transporter 0.0037 0.0172 0.0326
Schistosoma mansoni glutaminase 0.0558 0.3925 0.3925
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.007 0.1651
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0104 0.0178
Brugia malayi Dopamine receptor protein 1 0.0106 0.0665 0.1695
Treponema pallidum sodium- and chloride- dependent transporter 0.0182 0.1217 1
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0446 0.1202
Leishmania major potassium channel subunit-like protein 0.0037 0.0172 0.3271
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0446 0.0762
Entamoeba histolytica cysteine protease, putative 0.002 0.0048 0.0199
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.007 0.0613
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0458 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Brugia malayi Melatonin receptor type 1A 0.0106 0.0665 0.1695
Onchocerca volvulus 0.0106 0.0665 0.5467
Onchocerca volvulus 0.0106 0.0665 0.5467
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0446 0.1137
Echinococcus granulosus intermediate filament protein 0.0028 0.0104 0.0104
Brugia malayi MH2 domain containing protein 0.0025 0.0084 0.0215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Brugia malayi MH1 domain containing protein 0.0025 0.0084 0.0215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Onchocerca volvulus 0.0037 0.0172 0.1417
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0086
Echinococcus granulosus sex peptide receptor 0.0106 0.0665 0.0665
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0037 0.0172 0.3271
Echinococcus granulosus biogenic amine 5HT receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) uncoordinated protein 58 0.0037 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0106 0.0665 0.5467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0086
Brugia malayi beta-lactamase family protein 0.0075 0.0446 0.1137
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.0664
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0126 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0048 0.0048
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0037 0.0172 0.0439
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0037 0.0172 0.0439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0762
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0106 0.0665 0.1137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0046 0.003
Schistosoma mansoni biogenic amine receptor 0.0106 0.0665 0.0665
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0106 0.0665 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Echinococcus granulosus neuropeptide receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0206 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0214 0.0544
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0446 0.1137
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0106 0.0665 0.0651
Loa Loa (eye worm) solute carrier family 6 member 4 0.0182 0.1217 0.2079
Giardia lamblia Hypothetical protein 0.0037 0.0172 0.0532
Plasmodium vivax vivapain-2 0.002 0.0048 0.0057
Toxoplasma gondii hypothetical protein 0.0031 0.0126 0.199
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0446 0.9727
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0126 0.011
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.1826 0.312
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0294 0.0502
Brugia malayi intermediate filament protein 0.0028 0.0104 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0333 0.0333
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.007 0.0209
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.016 0.0273
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Schistosoma mansoni amine GPCR 0.0106 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0106 0.0665 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0106 0.0665 0.0665
Schistosoma mansoni intermediate filament proteins 0.0028 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0826 0.5854 1
Echinococcus granulosus neuropeptide Y receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.0086
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0294 0.613
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0214 0.4251
Schistosoma mansoni calcium-activated potassium channel 0.0037 0.0172 0.0172
Echinococcus granulosus small conductance calcium activated potassium 0.0826 0.5854 0.5854
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0046 0.0117
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0106 0.0665 0.0651
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0458 1
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0037 0.0172 0.3271
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0046 0.0289
Mycobacterium ulcerans ion transport protein 0.0037 0.0172 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0294 0.0748
Echinococcus multilocularis dro:myosuppressin receptor 0.0106 0.0665 0.0651
Loa Loa (eye worm) G-protein coupled receptor 0.0106 0.0665 0.1137
Brugia malayi hypothetical protein 0.0106 0.0665 0.1695
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0446 0.1202
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.1165 0.9571
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0458 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0193 0.0493
Plasmodium vivax amine transporter, putative 0.0031 0.0126 0.199
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0037 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Brugia malayi MH2 domain containing protein 0.037 0.2571 0.6552
Brugia malayi MAP kinase sur-1 0.0053 0.0283 0.0722
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0998 0.0998
Onchocerca volvulus 0.0106 0.0665 0.5467
Echinococcus multilocularis tumor protein p63 0.0408 0.2844 0.2833
Schistosoma mansoni amine GPCR 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Onchocerca volvulus 0.0106 0.0665 0.5467
Onchocerca volvulus 0.0106 0.0665 0.5467
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0986 0.0986
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.0117
Schistosoma mansoni lamin 0.0028 0.0104 0.0104
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.035 0.2424 1
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.0664
Loa Loa (eye worm) G-protein coupled receptor 0.0106 0.0665 0.1137
Plasmodium falciparum potassium channel 0.0037 0.0172 0.8514
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0037 0.0172 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0446 0.1202
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0034 0.0034
Onchocerca volvulus 0.0028 0.0104 0.0855
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0048 0.0155
Plasmodium falciparum transporter, putative 0.0031 0.0126 0.5362
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0126 0.0126
Loa Loa (eye worm) glutaminase 0.0558 0.3925 0.6705
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0193 0.3685
Onchocerca volvulus 0.002 0.0048 0.0396
Onchocerca volvulus 0.0037 0.0172 0.1417
Echinococcus granulosus neuropeptide receptor 0.0106 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Echinococcus granulosus serotonin receptor 0.0106 0.0665 0.0665
Onchocerca volvulus 0.0028 0.0104 0.0855
Schistosoma mansoni calcium-activated potassium channel 0.0037 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0214 0.0544
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0106 0.0665 0.0665
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0106 0.0665 0.0651
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0665 0.0665
Leishmania major hypothetical protein, conserved 0.0075 0.0446 0.9727
Echinococcus granulosus neuropeptide Y receptor 0.0106 0.0665 0.0665
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0446 0.1202
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0283 0.593
Onchocerca volvulus Huntingtin homolog 0.0122 0.0783 0.6431
Schistosoma mansoni smad1 5 8 and 0.0025 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0182 0.1217 0.2079
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Brugia malayi Dopamine receptor 0.0106 0.0665 0.1695
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1826 0.4653
Echinococcus granulosus calcium activated potassium channel variant 0.0037 0.0172 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0261 0.0664
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Brugia malayi hypothetical protein 0.0037 0.0172 0.0439
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0294 0.1211
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0161 0.0161
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.007 0.0613
Schistosoma mansoni Smad4 0.0025 0.0084 0.0084
Onchocerca volvulus 0.0182 0.1217 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0925 0.0925
Echinococcus granulosus smad 0.0025 0.0084 0.0084
Schistosoma mansoni neuropeptide F-like receptor 0.0106 0.0665 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0665 0.0651
Schistosoma mansoni hypothetical protein 0.0106 0.0665 0.0665
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.0032
Brugia malayi neuropeptide F receptor 0.0106 0.0665 0.1695
Echinococcus multilocularis neuropeptide Y receptor 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Loa Loa (eye worm) hypothetical protein 0.0122 0.0783 0.1337
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0294 0.613
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0665 0.0651
Echinococcus multilocularis geminin 0.0701 0.4953 0.4945
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0083 0.05 0.0854
Loa Loa (eye worm) fibroinase 0.002 0.0048 0.0082
Leishmania major cysteine peptidase A (CPA) 0.002 0.0048 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0925 0.0925
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0955 0.0955
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0925 0.2357
Loa Loa (eye worm) hypothetical protein 0.0385 0.2678 0.4576
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0106 0.0665 0.0651
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0106 0.0665 0.0665
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0126 0.032
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0106 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0113 0.0289
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.007 0.0867
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0106 0.0665 0.0651
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Schistosoma mansoni smad 0.0025 0.0084 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0925 0.0925
Echinococcus multilocularis lamin 0.0028 0.0104 0.0088
Schistosoma mansoni hypothetical protein 0.0037 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0665 0.0651
Plasmodium falciparum potassium channel 0.0037 0.0172 0.8514
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0084 0.0069
Loa Loa (eye worm) TWK-7 protein 0.0037 0.0172 0.0294
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0106 0.0665 0.0665
Echinococcus multilocularis orexin receptor type 2 0.0106 0.0665 0.0651
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus granulosus g protein coupled receptor 0.0106 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0034 0.0147 0.0147
Echinococcus granulosus dro:myosuppressin receptor 0.0106 0.0665 0.0665
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0126 0.0126
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.007 1
Loa Loa (eye worm) cysteine protease 0.002 0.0048 0.0082
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0034
Echinococcus multilocularis twik family of potassium channels 0.0037 0.0172 0.0157
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0084 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus multilocularis fmrfamide receptor 0.0106 0.0665 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0134 0.0341
Echinococcus granulosus geminin 0.0701 0.4953 0.4953
Mycobacterium tuberculosis Conserved protein 0.0075 0.0446 0.1202
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0126 0.0126
Echinococcus granulosus biogenic amine 5HT receptor 0.0106 0.0665 0.0665
Schistosoma mansoni smad1 5 8 and 0.0025 0.0084 0.0084
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0458 1
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Giardia lamblia GTOR 0.0054 0.0294 0.1042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0925 0.0925
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0294 0.613
Echinococcus multilocularis small conductance calcium activated potassium 0.0826 0.5854 0.5847
Brugia malayi GnHR receptor homolog 0.0106 0.0665 0.1695
Brugia malayi MH1 domain containing protein 0.0014 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0261 0.0445
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0037 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0123
Echinococcus granulosus hypothetical protein 0.0106 0.0665 0.0665
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0665 0.0651
Echinococcus multilocularis potassium channel subfamily K 8 0.0037 0.0172 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0458 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.0048
Mycobacterium ulcerans lipase LipD 0.0075 0.0446 0.1032
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Mycobacterium tuberculosis Conserved protein 0.0075 0.0446 0.1202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0294
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0283 0.5886
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.1137
Echinococcus multilocularis potassium channel subfamily K 8 0.0037 0.0172 0.0157
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0172 0.0172
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.112 0.462
Loa Loa (eye worm) ctsf protein 0.002 0.0048 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1165 0.2967
Schistosoma mansoni myosin xvIII 0.0106 0.0665 0.0665

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1167 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2328 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3621 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 16.4816 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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