Detailed information for compound 1386264

Basic information

Technical information
  • TDR Targets ID: 1386264
  • Name: N-(2-amino-2-oxoethyl)-4-[(2-methoxyphenyl)-m ethylsulfamoyl]-N-propan-2-ylbenzamide
  • MW: 419.495 | Formula: C20H25N3O5S
  • H donors: 1 H acceptors: 4 LogP: 1.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N(S(=O)(=O)c1ccc(cc1)C(=O)N(C(C)C)CC(=O)N)C
  • InChi: 1S/C20H25N3O5S/c1-14(2)23(13-19(21)24)20(25)15-9-11-16(12-10-15)29(26,27)22(3)17-7-5-6-8-18(17)28-4/h5-12,14H,13H2,1-4H3,(H2,21,24)
  • InChiKey: QIMMZBPXRAYFPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-amino-2-oxo-ethyl)-N-isopropyl-4-[(2-methoxyphenyl)-methyl-sulfamoyl]benzamide
  • N-(2-amino-2-oxoethyl)-N-isopropyl-4-[(2-methoxyphenyl)-methylsulfamoyl]benzamide
  • N-(2-amino-2-keto-ethyl)-N-isopropyl-4-[(2-methoxyphenyl)-methyl-sulfamoyl]benzamide
  • N-(2-amino-2-oxo-ethyl)-4-[(2-methoxyphenyl)-methyl-sulfamoyl]-N-propan-2-yl-benzamide
  • MLS000566409
  • ZINC03352750
  • SMR000153494
  • T5326001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0016 0.0095 0.1648
Giardia lamblia Cysteine protease 0.0016 0.0095 0.0252
Echinococcus granulosus importin subunit beta 1 0.0035 0.033 0.0718
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0177 0.0421
Echinococcus granulosus cathepsin L 0.0016 0.0095 0.0203
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0545 0.1593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Echinococcus multilocularis importin subunit beta 1 0.0035 0.033 0.0329
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0485 0.1048
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0033 0.0097
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0033 0.0031
Onchocerca volvulus 0.0012 0.0041 0.0648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.065 0.1408
Loa Loa (eye worm) MBCTL1 0.0054 0.0568 0.1236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0568 0.1673
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0065 0.0532
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.0065 0.0532
Brugia malayi cathepsin L precursor 0.0016 0.0095 0.0279
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1086 0.2652
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0362 0.6609
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Giardia lamblia Hypothetical protein 0.0016 0.0095 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0095 0.0194
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0054 0.0897
Onchocerca volvulus 0.0052 0.0545 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0414 0.7577
Schistosoma mansoni smad1 5 8 and 0.001 0.0015 0.0019
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0006 0.0004
Leishmania major hypothetical protein, conserved 0.0036 0.034 0.3011
Leishmania major trypanothione reductase 0.0037 0.0362 0.3216
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0015 0.0029
Echinococcus granulosus chromobox protein 1 0.0069 0.0759 0.1655
Echinococcus granulosus cathepsin l1 0.0052 0.0545 0.1187
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0369 0.0802
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.171 0.373
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.0065 0.0532
Toxoplasma gondii cathepsin B 0.0097 0.1114 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0054 0.0436
Brugia malayi hypothetical protein 0.0011 0.0033 0.0097
Trypanosoma brucei p-glycoprotein 0.0014 0.0065 0.0532
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.034 0.0946
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0095 0.0194
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0277 0.0817
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0485 0.1057
Echinococcus granulosus cathepsin b 0.0277 0.3392 0.7403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0016 0.0095 0.1648
Echinococcus granulosus cathepsin l1 0.0037 0.0363 0.0789
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0214 0.3861
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0214 0.3861
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0545 0.1187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.034 0.0819
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0568 0.1236
Mycobacterium ulcerans beta-lactamase 0.0036 0.034 0.0819
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0095 0.0263
Echinococcus multilocularis chromobox protein 1 0.0069 0.0759 0.0758
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0115
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.1114 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0015 0.0013
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Giardia lamblia Encystation-specific protease 0.0016 0.0095 0.0252
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0485 0.1048
Brugia malayi Importin beta-1 subunit 0.0035 0.033 0.0973
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0065 0.0138
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0095 0.0279
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0378 0.6892
Brugia malayi Alpha/beta hydrolase 0.0009 0.0006 0.0017
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1671 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0095 0.0194
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0054 0.0436
Giardia lamblia Cathepsin L-like protease 0.0016 0.0095 0.0252
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0247 0.0684
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0015 0.0029
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0545 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0214 0.0631
Plasmodium vivax importin-beta 2, putative 0.0035 0.033 0.6011
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0545 0.1187
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0545 1
Giardia lamblia Cysteine protease 0.0016 0.0095 0.0252
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.3534 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0065 0.0174
Mycobacterium tuberculosis Conserved protein 0.0036 0.034 0.0819
Leishmania major pentamidine resistance protein 1 0.0014 0.0065 0.0532
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0177 0.3179
Giardia lamblia ABC transporter, putative 0.0014 0.0065 0.0167
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1086 0.2652
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0054 0.0436
Brugia malayi beta-lactamase family protein 0.0036 0.034 0.1001
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0277 0.3392 0.7401
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.0065 0.0174
Brugia malayi beta-lactamase 0.0036 0.034 0.1001
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0545 0.1593
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0065 0.0532
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0053 0.0113
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0966 0.2357
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0545 0.0544
Brugia malayi Thioredoxin reductase 0.0037 0.0362 0.1068
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0065 0.0167
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0065 0.0138
Brugia malayi CXXC zinc finger family protein 0.0028 0.0249 0.0733
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0033 0.0097
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0016 0.0095 0.1648
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0095 0.1648
Toxoplasma gondii cathepsin CPL 0.0052 0.0545 0.4866
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1086 0.6491
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0436
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Trypanosoma brucei trypanothione reductase 0.0037 0.0362 0.3216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Brugia malayi mbt repeat family protein 0.0047 0.0485 0.1431
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0095 0.0252
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0363 0.1011
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0545 0.0544
Echinococcus granulosus cathepsin L 0.0031 0.0277 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Entamoeba histolytica ABC transporter, putative 0.0014 0.0065 0.0167
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0065 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0568 0.0566
Echinococcus granulosus chromobox protein 1 0.0069 0.0759 0.1655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0277 0.077
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0033 0.0503
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.034 0.0819
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0363 0.078
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0759 0.2135
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0024 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0277 0.077
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0054 0.0137
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0759 0.2135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0033 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0016 0.0095 0.0252
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0015 0.0029
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0006 0.0017
Giardia lamblia Cathepsin B precursor 0.0016 0.0095 0.0252
Echinococcus multilocularis cysteine protease 0.0052 0.0545 0.0544
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0073 0.0157
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.1114 1
Onchocerca volvulus 0.0037 0.0363 0.6614
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0568 0.0566
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0545 0.1607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Loa Loa (eye worm) helicase 0.0011 0.0033 0.0069
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0065 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0095 0.0279
Schistosoma mansoni hypothetical protein 0.0167 0.2003 0.4366
Schistosoma mansoni importin beta-1 0.0035 0.033 0.0709
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0362 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0568 0.1228
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0095 0.0279
Giardia lamblia Cathepsin B precursor 0.0097 0.1114 0.3142
Onchocerca volvulus 0.0036 0.034 0.6187
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0545 0.1529
Onchocerca volvulus 0.0052 0.0545 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.0966 0.2357
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0076 0.02
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Loa Loa (eye worm) glutathione reductase 0.0037 0.0362 0.0788
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0095 0.0252
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0966 0.2357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0177 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0011 0.0032
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Brugia malayi MH2 domain containing protein 0.001 0.0015 0.0043
Leishmania major ABC-thiol transporter 0.0014 0.0065 0.0532
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0065 0.0167
Mycobacterium ulcerans epoxide hydrolase EphA 0.0332 0.4081 1
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.034 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0095 0.0252
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0277 0.3392 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0095 0.0203
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0277 0.077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.034 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.171 0.373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0485 0.889
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0363 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3392 0.7401
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0016 0.0095 0.1648
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0033 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0363 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0095 0.0252
Onchocerca volvulus 0.0036 0.034 0.6187
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0033 0.0503
Schistosoma mansoni cathepsin s 0.0014 0.0073 0.0148
Schistosoma mansoni hypothetical protein 0.0167 0.2003 0.4366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.034 0.0338
Giardia lamblia Cathepsin B precursor 0.0016 0.0095 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0277 0.245
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0016 0.0095 0.0252
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Onchocerca volvulus 0.0052 0.0545 1
Leishmania major p-glycoprotein e 0.0014 0.0065 0.0532
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0966 0.2357
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0485 0.1057
Plasmodium vivax vivapain-3 0.0031 0.0277 0.5034
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Schistosoma mansoni chromobox protein 0.0011 0.0033 0.0059
Echinococcus multilocularis cathepsin L 0.0016 0.0095 0.0093
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0033 0.0077
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Plasmodium falciparum thioredoxin reductase 0.0037 0.0362 0.6609
Plasmodium vivax vivapain-2 0.0052 0.0545 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0095 0.0194
Schistosoma mansoni smad 0.001 0.0015 0.0019
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0009 0.0006 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Echinococcus multilocularis cathepsin b 0.0277 0.3392 0.3391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0363 0.1011
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0095 0.0263
Brugia malayi fibroinase precursor 0.0016 0.0095 0.0279
Mycobacterium tuberculosis Conserved protein 0.0036 0.034 0.0819
Brugia malayi Protein cec-1. 0.0011 0.0033 0.0097
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2292 0.2291
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0114 0.0307
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2758 0.6755
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0015 0.0029
Echinococcus multilocularis chromobox protein 1 0.0069 0.0759 0.0758
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0009 0.0006 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0545 0.1179
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0016 0.0095 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0095 0.0194
Trypanosoma cruzi hypothetical protein 0.0011 0.0024 0.0055
Brugia malayi cathepsin Z-like cysteine proteinase 0.0016 0.0095 0.0279
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1086 0.2652
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0362 0.0788
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Echinococcus multilocularis chromobox protein 2 0.0011 0.0033 0.0031
Giardia lamblia Cathepsin B precursor 0.0097 0.1114 0.3142
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0414 0.1159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0015 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0177 0.0384
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Plasmodium falciparum serine repeat antigen 2 0.0016 0.0095 0.1648
Entamoeba histolytica hypothetical protein 0.0011 0.0033 0.0077
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0177 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0651
Mycobacterium ulcerans lipase LipD 0.0036 0.034 0.0819
Giardia lamblia Cathepsin B precursor 0.0016 0.0095 0.0252
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0138
Entamoeba histolytica hypothetical protein 0.0011 0.0033 0.0077
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0576
Schistosoma mansoni hypothetical protein 0.0372 0.4581 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Schistosoma mansoni ran 0.0026 0.0214 0.0455
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0545 0.1179
Brugia malayi cathepsin L-like cysteine proteinase 0.0016 0.0095 0.0279
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.034 0.0819
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0065 0.0063
Plasmodium vivax vivapain-1 0.0031 0.0277 0.5034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.007 0.0183
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0177 0.1547
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0033 0.0077
Brugia malayi Cathepsin L-like precursor 0.0014 0.0073 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0378 0.1054
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0277 0.077
Onchocerca volvulus 0.0052 0.0545 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1671 0.4085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Brugia malayi Heterochromatin protein 1 0.0069 0.0759 0.2238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0033 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0177 0.0486
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0277 0.0802
Giardia lamblia Cysteine protease 0.0016 0.0095 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.034 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0378 0.1054
Schistosoma mansoni multidrug resistance protein 0.0014 0.0065 0.0129
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0277 0.0602
Loa Loa (eye worm) ctsf protein 0.0052 0.0545 0.1187
Toxoplasma gondii cathepsin CPC1 0.0016 0.0095 0.0802
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0016 0.0095 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0095 0.0252
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0177 0.3179
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0065 0.0167
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0568 0.1236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0214 0.0464
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0545 0.1529
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.033 0.2925
Plasmodium falciparum serine repeat antigen 1 0.0016 0.0095 0.1648
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0485 0.1057
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0033 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0009 0.0006 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0177 0.0421
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0106
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0065 0.0167
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0009 0.0006 0.0009
Plasmodium vivax glutathione reductase, putative 0.0037 0.0362 0.6609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Loa Loa (eye worm) hypothetical protein 0.0054 0.0568 0.1236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Loa Loa (eye worm) cathepsin B 0.0097 0.1114 0.243
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0177 0.0486
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0095 0.0194
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0006 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3392 0.7401
Brugia malayi beta-lactamase family protein 0.0036 0.034 0.1001
Schistosoma mansoni ran 0.0026 0.0214 0.0455
Onchocerca volvulus 0.0052 0.0545 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0016 0.0095 0.1648
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0214 0.0464
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0277 0.077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0114 0.0307
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0095 0.0279
Loa Loa (eye worm) hydrolase 0.0009 0.0006 0.0009
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.034 0.0946
Leishmania major importin beta-1 subunit, putative 0.0028 0.0247 0.2176
Mycobacterium tuberculosis Conserved protein 0.0036 0.034 0.0819
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0545 0.4866
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0095 0.0194
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Echinococcus granulosus Smad4 0.001 0.0015 0.0029
Schistosoma mansoni multidrug resistance protein 0.0014 0.0065 0.0129
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0033 0.0503
Giardia lamblia Cathepsin B precursor 0.0016 0.0095 0.0252
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0277 0.0802
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.003 0.0272 0.0592
Echinococcus multilocularis snurportin 1 0.0372 0.4581 0.458
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0054 0.0897
Brugia malayi glutathione reductase 0.0037 0.0362 0.1068
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4581 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0363 0.1069
Onchocerca volvulus 0.0016 0.0095 0.1648
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0247 0.0712
Echinococcus multilocularis cathepsin b 0.0277 0.3392 0.3391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0033 0.0077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0095 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0054 0.0897
Echinococcus granulosus smad 0.001 0.0015 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.3534 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0033 0.0077
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0119
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0009 0.0006 0.0004
Loa Loa (eye worm) cysteine protease 0.0052 0.0545 0.1187
Trichomonas vaginalis hypothetical protein 0.0011 0.0033 0.0077
Brugia malayi RNA, U transporter 1 0.0099 0.114 0.3361
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0033 0.0077
Schistosoma mansoni chromobox protein 0.0069 0.0759 0.1647
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0966 0.2357
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0545 0.1187
Schistosoma mansoni Smad4 0.001 0.0015 0.0019
Brugia malayi MH2 domain containing protein 0.0144 0.171 0.5041
Brugia malayi mbt repeat family protein 0.0047 0.0485 0.1431
Mycobacterium leprae conserved hypothetical protein 0.0036 0.034 0.2005
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0214 0.059
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0759 0.1655
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0277 0.0802
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0214 0.1879
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0065 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0789
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0065 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0016 0.0095 0.0279
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0065 0.0167
Plasmodium vivax unspecified product 0.0016 0.0095 0.1648
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0095 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0016 0.0095 0.1648
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0054 0.5
Plasmodium falciparum serine repeat antigen 5 0.0016 0.0095 0.1648
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2292 0.5001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3534 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0789
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0016 0.0095 0.0252
Loa Loa (eye worm) fibroinase 0.0052 0.0545 0.1187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Echinococcus multilocularis smad 0.001 0.0015 0.0013
Onchocerca volvulus 0.0036 0.034 0.6187
Brugia malayi MH1 domain containing protein 0.001 0.0015 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0177 0.0507
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0054 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0036 0.034 0.6187
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0033 0.0077
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0362 0.1053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0789
Entamoeba histolytica cysteine protease, putative 0.0052 0.0545 0.1529
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0545 0.1593
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0054 0.0897
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0277 0.0594
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0277 0.0802
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0053
Loa Loa (eye worm) multidrug resistance-associated protein 0.0011 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.0065 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0037 0.0363 0.1054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0576
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0545 1
Onchocerca volvulus 0.0047 0.0485 0.889
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0247 0.0684
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0024 0.0023
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.034 0.0819
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0966 0.577
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0177 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0545 0.1593
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Brugia malayi SET domain containing protein 0.0012 0.0041 0.012
Echinococcus granulosus Chromo domain 0.0011 0.0033 0.0069
Onchocerca volvulus 0.003 0.0272 0.4942
Echinococcus granulosus cysteine protease 0.0031 0.0277 0.0602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.034 0.073
Schistosoma mansoni hypothetical protein 0.0291 0.3564 0.7776
Echinococcus multilocularis cysteine protease 0.0052 0.0545 0.0544
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0033 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0095 0.0252
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Schistosoma mansoni multidrug resistance protein 0.0014 0.0065 0.0129
Loa Loa (eye worm) hypothetical protein 0.0277 0.3392 0.7403
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0545 1
Echinococcus multilocularis Chromo domain 0.0011 0.0033 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0252
Giardia lamblia MRP-like ABC transporter 0.0014 0.0065 0.0167
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0214 0.0615
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0332 0.4081 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0277 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0277 0.0594
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0054 0.0436
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0569 0.5081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Brugia malayi CHD4 protein 0.0013 0.0053 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0041 0.0076
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0016 0.0095 0.0252
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0177 0.0176
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.034 0.0946
Toxoplasma gondii ABC1 family protein 0.0036 0.034 0.3011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0966 0.2357
Brugia malayi MH1 domain containing protein 0.001 0.0015 0.0043
Giardia lamblia Cathepsin B precursor 0.0097 0.1114 0.3142
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0016 0.0095 0.0252
Toxoplasma gondii exonuclease III APE 0.0023 0.0177 0.1547
Echinococcus multilocularis abhydrolase domain containing 3 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.034 0.0819
Brugia malayi alpha/beta hydrolase 0.0009 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Schistosoma mansoni ap endonuclease 0.0023 0.0177 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0177 0.0384
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0277 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0076 0.02
Plasmodium falciparum glutathione reductase 0.0037 0.0362 0.6609
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0016 0.0095 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Plasmodium falciparum importin beta, putative 0.0035 0.033 0.6011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Trichomonas vaginalis esterase, putative 0.0036 0.034 0.0946
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0157
Brugia malayi cathepsin B-like cysteine proteinase 0.0277 0.3392 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.033 0.2925
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0095 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0014 0.0073 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Echinococcus granulosus geminin 0.0167 0.2003 0.4371
Plasmodium falciparum serine repeat antigen 6 0.0016 0.0095 0.1648
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0065 0.0167
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0249 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.034 0.0946
Echinococcus multilocularis cathepsin L 0.0031 0.0277 0.0276
Mycobacterium ulcerans hypothetical protein 0.0036 0.034 0.0819
Schistosoma mansoni smad1 5 8 and 0.001 0.0015 0.0019
Plasmodium falciparum serine repeat antigen 9 0.0016 0.0095 0.1648
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0033 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Giardia lamblia Hypothetical protein 0.0016 0.0095 0.0252
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0545 1
Entamoeba histolytica hypothetical protein 0.0014 0.0065 0.0167
Echinococcus granulosus abhydrolase domain containing protein 3 0.0009 0.0006 0.0009
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0095 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Echinococcus granulosus snurportin 1 0.0372 0.4581 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.1114 0.3142
Echinococcus granulosus cathepsin b 0.0277 0.3392 0.7403
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0545 0.1187
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0054 0.0436
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0214 0.0213
Entamoeba histolytica hypothetical protein 0.0011 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0033 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0073 0.02
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0033 0.0503
Toxoplasma gondii thioredoxin reductase 0.0037 0.0362 0.3216
Echinococcus granulosus Chromobox protein 3 0.0011 0.0033 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0485 0.0484
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0718
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0277 0.077
Giardia lamblia Cathepsin L-like protease 0.0016 0.0095 0.0252
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0016 0.0095 0.1648
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0011 0.0032
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0016 0.0095 0.1648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0545 0.1529
Leishmania major GTP-binding protein, putative 0.0026 0.0214 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Brugia malayi UPF0017 protein CG3488 0.0009 0.0006 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0436
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0047 0.0485 0.1057
Plasmodium falciparum serine repeat antigen 3 0.0016 0.0095 0.1648
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0277 0.077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.034 0.0819
Brugia malayi Cathepsin L-like precursor 0.0052 0.0545 0.1607
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0095 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.1114 0.2423
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0138
Giardia lamblia Cathepsin B precursor 0.0016 0.0095 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0033 0.0077
Onchocerca volvulus 0.0052 0.0545 1
Brugia malayi multidrug resistance related protein 1 0.0014 0.0065 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0545 0.1529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0177 0.0507
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0033 0.0059
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0247 0.0684
Plasmodium falciparum serine repeat antigen 7 0.0016 0.0095 0.1648
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Giardia lamblia Cysteine protease 0.0016 0.0095 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0277 0.245
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0095 0.1648
Plasmodium falciparum serine repeat antigen 4 0.0016 0.0095 0.1648
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0016 0.0095 0.1648
Brugia malayi MH2 domain containing protein 0.001 0.0015 0.0043
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0053 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0177 0.1547
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0054 0.0143
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.033 0.2925
Entamoeba histolytica Ran family GTPase 0.0026 0.0214 0.059
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0054 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0054 0.0143
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0095 0.0194
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0054 0.0119
Echinococcus granulosus cpg binding protein 0.003 0.0269 0.0584
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.034 0.0738
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0073 0.0216
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0016 0.0095 0.1648
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0277 0.0817
Plasmodium falciparum glutathione reductase 0.0013 0.0054 0.0897
Mycobacterium leprae Probable lipase LipE 0.0036 0.034 0.2005
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0063 0.0163
Loa Loa (eye worm) Smad1 0.001 0.0015 0.0029
Trichomonas vaginalis ran, putative 0.0026 0.0214 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0033 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.034 0.3011
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0015 0.0013
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Schistosoma mansoni smad1 5 8 and 0.001 0.0015 0.0019
Plasmodium vivax unspecified product 0.0031 0.0277 0.5034
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0065 0.0063
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.3534 1
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0054 0.0137
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0414 0.1159
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0054 0.0119
Onchocerca volvulus 0.0011 0.0033 0.0503
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0485 0.1048
Schistosoma mansoni multidrug resistance protein 0.0014 0.0065 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0545 0.4866
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0054 0.0119
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0016 0.0095 0.1648
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0651
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0054 0.0436
Trypanosoma cruzi cruzipain precursor, putative 0.0014 0.0073 0.02
Schistosoma mansoni cpg binding protein 0.0028 0.0249 0.0531
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0065 0.0167
Echinococcus granulosus chromobox protein 2 0.0011 0.0033 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0545 0.0544
Toxoplasma gondii cathepsin CPC2 0.0016 0.0095 0.0802
Echinococcus multilocularis cpg binding protein 0.003 0.0269 0.0268
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0033 0.0503
Plasmodium vivax serine-repeat antigen (SERA) 0.0016 0.0095 0.1648
Echinococcus multilocularis geminin 0.0167 0.2003 0.2002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0054 0.0436
Giardia lamblia Cathepsin L precursor 0.0016 0.0095 0.0252
Plasmodium falciparum serine repeat antigen 8 0.0016 0.0095 0.1648
Echinococcus multilocularis Smad4 0.001 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0738
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0277 0.077
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0033 0.0503
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.034 0.1001
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0095 0.1648
Schistosoma mansoni ap endonuclease 0.0023 0.0177 0.0375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.034 0.073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0095 0.0252
Schistosoma mansoni chromobox protein 0.0011 0.0033 0.0059
Echinococcus granulosus abhydrolase domain containing protein 11 0.0009 0.0006 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0369 0.0367
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0009 0.0006 0.0009
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0065 0.0532
Plasmodium vivax vivapain-2 0.0052 0.0545 1
Brugia malayi Smad1 0.001 0.0015 0.0043
Onchocerca volvulus 0.0011 0.0033 0.0503
Toxoplasma gondii preprocathepsin c precursor, putative 0.0016 0.0095 0.0802
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.034 0.0946
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0203
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0033 0.0245
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.1114 0.3274
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.034 0.0819
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0095 0.0252
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0006 0.0017
Entamoeba histolytica cysteine protease, putative 0.0016 0.0095 0.0252
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0095 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Brugia malayi Cathepsin L-like precursor 0.0037 0.0363 0.1069
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0545 1
Echinococcus granulosus abhydrolase domain containing protein 0.0009 0.0006 0.0009
Onchocerca volvulus 0.0052 0.0545 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.0065 0.0532
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0545 0.1593
Leishmania major cathepsin L-like protease 0.0052 0.0545 0.4866
Entamoeba histolytica cysteine protease, putative 0.0031 0.0277 0.077
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0095 0.0279
Loa Loa (eye worm) beta-lactamase 0.0036 0.034 0.0738
Brugia malayi chromobox protein homolog 3 0.0039 0.0378 0.1113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0095 0.0194
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0177 0.0486
Entamoeba histolytica hypothetical protein 0.0016 0.0095 0.0252
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0485 0.0484
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0545 0.0544
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0157
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0177 0.0354
Echinococcus multilocularis abhydrolase domain containing protein 0.0009 0.0006 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0114 0.0307
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0069
Schistosoma mansoni chromobox protein 0.0069 0.0759 0.1647
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0214 0.0615
Plasmodium falciparum thioredoxin reductase 0.0013 0.0054 0.0897
Plasmodium vivax unspecified product 0.0014 0.0073 0.1254
Schistosoma mansoni cathepsin C 0.0016 0.0095 0.0194
Entamoeba histolytica hypothetical protein 0.0028 0.0247 0.0684
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0214 0.1879
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1671 0.4085
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0033 0.0031
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0053 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0545 0.1529
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0545 0.1187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.3534 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0016 0.0095 0.1648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0545 0.1529
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.034 0.0986
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.034 0.0819
Brugia malayi cathepsin L-like precursor 0.0037 0.0363 0.1069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0277 0.0594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3392 0.7401
Onchocerca volvulus 0.0028 0.0249 0.4504

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1995 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.