Detailed information for compound 1387853

Basic information

Technical information
  • TDR Targets ID: 1387853
  • Name: 2-[2-(1-adamantylamino)-2-oxoethoxy]benzamide
  • MW: 328.405 | Formula: C19H24N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC12CC3CC(C2)CC(C1)C3)COc1ccccc1C(=O)N
  • InChi: 1S/C19H24N2O3/c20-18(23)15-3-1-2-4-16(15)24-11-17(22)21-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,12-14H,5-11H2,(H2,20,23)(H,21,22)
  • InChiKey: FOGKNUFCEUUUJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(1-adamantylamino)-2-oxo-ethoxy]benzamide
  • 2-[2-(1-adamantylamino)-2-keto-ethoxy]benzamide
  • MLS000568042
  • SMR000154427
  • ZINC04550325
  • T5669514

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0259 0.3167 0.369
Loa Loa (eye worm) hypothetical protein 0.012 0.1365 0.2355
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0286 0.3519
Leishmania major hypothetical protein, conserved 0.0072 0.0736 0.9748
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0365 0.0425
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0446 0.6059
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0115
Brugia malayi hypothetical protein 0.0147 0.1713 0.2956
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0381 0.0381
Schistosoma mansoni smad 0.0016 0.0005 0.0006
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Brugia malayi G protein-coupled receptor 0.0027 0.0158 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0 0.0003
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0161 0.0187
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0057 0.0538 0.0929
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0736 0.2082
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.1239
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0057 0.0538 0.0929
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0094
Brugia malayi hypothetical protein 0.005 0.0446 0.0769
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0259 0.3167 0.369
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0286 0.3519
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0161 0.1975
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3533 1
Echinococcus granulosus cpg binding protein 0.0034 0.0243 0.0283
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.6234 0.6234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.5778 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0041 0.0551
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 0.5
Echinococcus multilocularis zinc finger protein 0.0025 0.013 0.013
Brugia malayi G-protein coupled receptor 0.0027 0.0158 0.0272
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0006
Brugia malayi RNA, U transporter 1 0.0079 0.0831 0.1435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0546 0.0636
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0288 0.0498
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0736 0.1273
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus smad 0.0016 0.0005 0.0006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.032 0.2569
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0436 0.5475 0.638
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0161 0.2184
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0403 0.0696
Schistosoma mansoni organic anion transporter 0.0028 0.0161 0.0187
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0736 0.0736
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0286 0.5317
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0094
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Schistosoma mansoni hypothetical protein 0.0674 0.8581 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0055 0.0015
Brugia malayi sulfakinin receptor protein 0.0027 0.0158 0.0272
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0057 0.0538 0.1523
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0158 0.0184
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0074 0.1377
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0055 0.0094
Brugia malayi Bromodomain containing protein 0.0092 0.1001 0.1728
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis agrin 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0028 0.0161 0.0211
Brugia malayi MH2 domain containing protein 0.0231 0.2813 0.4855
Echinococcus granulosus fmrfamide receptor 0.0027 0.0158 0.0184
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0158 0.0206
Trypanosoma brucei antigen, putative 0.002 0.0064 0.0865
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0446 0.548
Echinococcus granulosus FTZ F1 alpha 0.002 0.0055 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.6234 0.7265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0055 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Brugia malayi steroid hormone receptor 0.002 0.0055 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0436 0.5475 0.9448
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0158 0.0158
Onchocerca volvulus 0.0027 0.0158 0.0206
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0021 0.0074 0.0914
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0446 0.548
Schistosoma mansoni inositol monophosphatase 0.0045 0.0381 0.0444
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Brugia malayi ecdysteroid receptor 0.002 0.0055 0.0094
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0531 0.0618
Brugia malayi Serotonin receptor 0.0027 0.0158 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0064
Echinococcus multilocularis smad 0.0016 0.0005 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0158 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0163 0.2211
Leishmania major geranylgeranyltransferase, putative 0.0015 0 0.0003
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.0985
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Brugia malayi CXXC zinc finger family protein 0.003 0.0191 0.0329
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0055
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0161 0.0277
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Onchocerca volvulus 0.0027 0.0158 0.0206
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0149 0.1834
Echinococcus granulosus Smad4 0.0016 0.0005 0.0006
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0064 0.0865
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0158 0.0184
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0288 0.3816
Leishmania major hypothetical protein, conserved 0.0018 0.0041 0.0537
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus neuropeptide receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0724
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0476 0.0822
Echinococcus granulosus allatostatin A receptor 0.0027 0.0158 0.0184
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0158 0.0158
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0005
Brugia malayi hypothetical protein 0.0028 0.0161 0.0277
Brugia malayi neuropeptide F receptor 0.0027 0.0158 0.0272
Echinococcus multilocularis caspase 2 0.012 0.1365 0.1365
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Echinococcus granulosus hypothetical protein 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Brugia malayi beta-lactamase family protein 0.0072 0.0736 0.127
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0094
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0814 0.0948
Schistosoma mansoni hypothetical protein 0.0036 0.0262 0.0306
Onchocerca volvulus 0.0027 0.0158 0.0206
Brugia malayi Pre-SET motif family protein 0.0252 0.3081 0.5317
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0015 0 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0427 0.5362 0.6249
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0446 0.6059
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.009 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0074 0.101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0158
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0055 0.0094
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.046 0.5794 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0381 0.468
Onchocerca volvulus 0.0028 0.0161 0.0211
Loa Loa (eye worm) hypothetical protein 0.0049 0.0441 0.076
Loa Loa (eye worm) hypothetical protein 0.0057 0.0546 0.0942
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0184
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Echinococcus multilocularis somatostatin receptor 0.0027 0.0158 0.0158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0286 0.3891
Loa Loa (eye worm) calpain family protein 1 0.004 0.0315 0.0543
Echinococcus granulosus geminin 0.0674 0.8581 1
Brugia malayi hypothetical protein 0.0228 0.2774 0.4788
Schistosoma mansoni zinc finger protein 0.0025 0.013 0.0152
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Brugia malayi hypothetical protein 0.012 0.1365 0.2355
Echinococcus multilocularis sex peptide receptor 0.0027 0.0158 0.0158
Echinococcus granulosus agrin 0.0019 0.0046 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0755 0.0879
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0158 0.0206
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Onchocerca volvulus 0.003 0.0191 0.0266
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0055 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0286 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0158 0.0272
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0278 0.0278
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Schistosoma mansoni hypothetical protein 0.0436 0.5475 0.638
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2813 0.4855
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus max protein X 0.046 0.5794 0.6753
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0158 0.0184
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0064
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0436 0.5475 0.638
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0046 0.008
Onchocerca volvulus 0.012 0.1365 0.2429
Toxoplasma gondii hypothetical protein 0.0021 0.0074 0.0914
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0288 0.3914
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0278 0.0324
Trypanosoma cruzi ISWI complex protein 0.0018 0.0041 0.0551
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0158 0.0272
Brugia malayi beta-lactamase family protein 0.0072 0.0736 0.127
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0158 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.009 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0055 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0 0.0003
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Brugia malayi Serotonin receptor 0.0027 0.0158 0.0272
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0464 0.0464
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0158 0.0184
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0079
Schistosoma mansoni bhlhzip transcription factor bigmax 0.046 0.5794 0.6753
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0054 0.0499 0.0861
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0283
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0067 0.0823
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0736 0.0857
Schistosoma mansoni survival motor neuron protein 0.0047 0.0407 0.0474
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Brugia malayi Probable ClpP-like protease 0.0078 0.0814 0.1404
Brugia malayi G-protein coupled receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0464 0.0541
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.061 0.829
Brugia malayi prostaglandin transporter 0.0028 0.0161 0.0277
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0436 0.5475 0.9448
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0288 0.0336
Schistosoma mansoni importin beta-1 0.0028 0.0163 0.019
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2774 0.3233
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0055 0.0064
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0027 0.0158 0.0206
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0149 0.1834
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0021 0.0074 0.0914
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus granulosus snurportin 1 0.0297 0.3672 0.4279
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.1377
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0158 0.0184
Trypanosoma brucei ISWI complex protein 0.0018 0.0041 0.0551
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0006
Mycobacterium ulcerans beta-lactamase 0.0072 0.0736 0.8524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0252 0.0294
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.2214 0.258
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0158 0.0158
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0158 0.0158
Echinococcus multilocularis calpain 0.002 0.0064 0.0064
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0158 0.0158
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0068 0.0068
Onchocerca volvulus 0.0072 0.0736 0.127
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0158 0.0184
Echinococcus granulosus tm gpcr rhodopsin 0.0542 0.6853 0.7987
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0094
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0158 0.0272
Echinococcus multilocularis geminin 0.0674 0.8581 0.8581
Schistosoma mansoni zinc finger protein 0.0018 0.0041 0.0047
Schistosoma mansoni hypothetical protein 0.0047 0.0407 0.0474
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0158 0.0158
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0177 0.0206
Brugia malayi Pre-SET motif family protein 0.0037 0.0278 0.048
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0158 0.0158
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0158 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0094
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0009
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Importin beta-1 subunit 0.0028 0.0163 0.0281
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Schistosoma mansoni ap endonuclease 0.0037 0.0286 0.0334
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0286 0.3793
Echinococcus granulosus inhibitor of apoptosis protein 0.0436 0.5475 0.638
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0736 0.8524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Cell death protein 3 precursor 0.012 0.1365 0.2355
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0436 0.5475 0.5475
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0068 0.0079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0158 0.0184
Plasmodium vivax geranylgeranyltransferase, putative 0.0015 0 0.0003
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Echinococcus granulosus calpain 5 0.002 0.0064 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0094
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0009
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Onchocerca volvulus 0.002 0.0055 0.0015
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.046 0.5794 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0736 0.1273
Echinococcus granulosus zinc finger protein 0.0025 0.013 0.0152
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0055 0.0094
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0158 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Brugia malayi hypothetical protein 0.0028 0.0161 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0094 0.0266
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0074 0.101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0027 0.0158 0.0206
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0286 0.2064
Brugia malayi Smad1 0.0016 0.0005 0.0009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0542 0.6853 0.6853
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0286 0.3891
Schistosoma mansoni agrin 0.0019 0.0046 0.0054
Trypanosoma brucei lanosterol synthase 0.0062 0.061 0.829
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0163 0.2
Onchocerca volvulus 0.0027 0.0158 0.0206
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0057 0.0538 0.6615
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0021 0.0074 0.0914
Schistosoma mansoni nuclear hormone receptor 0.002 0.0055 0.0064
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0161 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0158 0.0272
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0158 0.0184
Plasmodium falciparum geranylgeranyltransferase, putative 0.0015 0 0.0003
Onchocerca volvulus 0.0072 0.0736 0.127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.2214 0.258
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Onchocerca volvulus 0.0147 0.1713 0.3071
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0499 0.0581
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.0281
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0288 0.0814
Mycobacterium leprae Probable lipase LipE 0.0072 0.0736 0.8828
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0064
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3081 0.5317
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0546 0.0546
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0158 0.0158
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0115
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0736 0.0857
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0814 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0736 0.8828
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.0543
Echinococcus granulosus calpain 7 C02 family 0.002 0.0064 0.0074
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.1365 0.159
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Echinococcus multilocularis max protein X 0.046 0.5794 0.5794
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0177 0.0177
Echinococcus granulosus dna polymerase kappa 0.0037 0.0288 0.0336
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0436 0.5475 0.5475
Echinococcus multilocularis expressed protein 0.0019 0.0046 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.012 0.1365 0.159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0094
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0064
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0158 0.0158
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0286 0.081
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0286 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0021 0.0074 0.0087
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0755 0.1306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0286 0.0286
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0814 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0057 0.0538 1
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0288 0.0032
Giardia lamblia Prenyltransferase 0.0057 0.0538 1
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0057 0.0538 0.7315
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.061 0.829
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0381 0.0444
Brugia malayi Inositol-1 0.0045 0.0381 0.0657
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0124 0.0215
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus Cell death protein 3 homolog 0.012 0.1365 0.2429
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0736 0.1273
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0381 0.1077
Schistosoma mansoni bromodomain containing protein 0.0078 0.0817 0.0952
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0064
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.101
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0446 0.548
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0381 0.1077
Onchocerca volvulus 0.0033 0.0235 0.0348
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0158 0.0158
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0057 0.0538 0.0627
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0028 0.0161 0.0211
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0057 0.0538 0.6615
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0436 0.5475 0.9448
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0055
Toxoplasma gondii hypothetical protein 0.0027 0.0149 0.1834
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0005
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0057 0.0538 0.6615
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0381 0.1077
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0055 0.0055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0055 0.0064
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0158 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Trypanosoma cruzi protein farnesyltransferase, putative 0.0057 0.0538 0.7315
Trypanosoma cruzi protein farnesyltransferase, putative 0.0057 0.0538 0.7315
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0074 0.1377
Trypanosoma brucei unspecified product 0.0037 0.0288 0.3914
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0009
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0158 0.0184
Plasmodium falciparum importin beta, putative 0.0028 0.0163 0.2
Plasmodium vivax importin-beta 2, putative 0.0028 0.0163 0.2
Onchocerca volvulus 0.0436 0.5475 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0158 0.0272
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0158 0.0272
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Brugia malayi AKH receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0053 0.0493 0.085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0755 1
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0057 0.0538 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0094 0.0266
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0064 0.0064
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Entamoeba histolytica hypothetical protein 0.0023 0.0094 0.1744
Brugia malayi putative neuropeptide receptor 0.0027 0.0158 0.0272
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0158 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0736 0.9043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0286 0.3891
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0755 0.0879
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Onchocerca volvulus 0.0072 0.0736 0.127
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0094 0.1279
Onchocerca volvulus 0.0021 0.0074 0.0052
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0315 0.0315
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0381 0.1791
Loa Loa (eye worm) hypothetical protein 0.0052 0.0476 0.0822
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0446 0.6059
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0062 0.061 0.1056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0228 0.2774 0.4788
Loa Loa (eye worm) beta-lactamase 0.0072 0.0736 0.127
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0158 0.0272
Echinococcus multilocularis GPCR, family 2 0.0016 0.0014 0.0014
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0531
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0736 0.127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0158 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0055 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0158 0.0158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0158 0.0184
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0446 0.548
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0222
Leishmania major importin beta-1 subunit, putative 0.0023 0.0094 0.1247
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0814 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0259 0.3167 0.3167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0094
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0064 0.0074
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0087
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0288 0.5349
Echinococcus multilocularis follistatin 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0015 0 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0736 0.0857
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0288 0.0032
Brugia malayi Dopamine receptor protein 2 0.0027 0.0158 0.0272
Echinococcus granulosus sex peptide receptor 0.0027 0.0158 0.0184
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0161 0.0161
Brugia malayi calpain family protein 1 0.0054 0.0499 0.0861
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0278 0.3416
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Echinococcus granulosus serotonin receptor 0.0027 0.0158 0.0184
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0755 0.9277
Leishmania major DNA polymerase eta, putative 0.0037 0.0288 0.3816
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Brugia malayi nuclear receptor NHR-88 0.002 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0286 0.0494
Onchocerca volvulus 0.0047 0.0407 0.0664
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2774 0.2774
Schistosoma mansoni hypothetical protein 0.0297 0.3672 0.4279
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.5362 0.5362
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0464 0.0804
Schistosoma mansoni hypothetical protein 0.0674 0.8581 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Onchocerca volvulus 0.0027 0.0158 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0094
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0158 0.0158
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0814 0.0948
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0158 0.0184
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0814 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0158 0.0272
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0278 0.0324
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0055 0.0064
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.0769
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0476 0.0822
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0761 0.0761
Echinococcus granulosus GPCR family 2 0.0016 0.0014 0.0016
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0161 0.0277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0283
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0094
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0055 0.0015
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0158 0.0184
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0158 0.0184
Schistosoma mansoni calpain C (C02 family) 0.002 0.0064 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0736 0.2082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis cpg binding protein 0.0034 0.0243 0.0243
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0158
Brugia malayi calpain 7 0.002 0.0064 0.011
Schistosoma mansoni bhlhzip transcription factor bigmax 0.046 0.5794 0.6753
Loa Loa (eye worm) hypothetical protein 0.012 0.1365 0.2355
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0016
Schistosoma mansoni adenoreceptor 0.0027 0.0158 0.0184
Schistosoma mansoni neuropeptide receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0078 0.0814 0.1404
Brugia malayi Bromodomain containing protein 0.0046 0.0402 0.0694
Echinococcus multilocularis dna polymerase eta 0.0037 0.0288 0.0288
Onchocerca volvulus 0.0027 0.0158 0.0206
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.091
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.6234 0.6234
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0161 0.0161
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0158 0.0184
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0057 0.0538 0.0627
Onchocerca volvulus 0.0037 0.0278 0.0427
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0158 0.0158
Echinococcus granulosus apoptotic protease activating factor 1 0.012 0.1365 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0094
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0067 0.0067
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0074 0.021
Schistosoma mansoni biogenic amine receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0476 0.0822
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0618
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0158 0.0158
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0158 0.0158
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0736 0.1273
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0067 0.0823
Loa Loa (eye worm) hypothetical protein 0.0147 0.1713 0.2956
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0546 0.0636
Entamoeba histolytica Ran family GTPase 0.0021 0.0067 0.1239
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0531 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.2214 0.258
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0067 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0163 0.2211
Echinococcus granulosus calpain 0.002 0.0064 0.0074
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0158 0.0184
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0736 0.1273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0755 0.0879
Schistosoma mansoni calpain (C02 family) 0.002 0.0064 0.0074
Echinococcus multilocularis serotonin receptor 0.0027 0.0158 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0736 1
Brugia malayi neuropeptide F receptor 0.0027 0.0158 0.0272
Schistosoma mansoni Smad4 0.0016 0.0005 0.0006
Trypanosoma brucei calpain-like protein, putative 0.002 0.0064 0.0865
Toxoplasma gondii exonuclease III APE 0.0037 0.0286 0.3519
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0381 0.1791
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0286 0.0334
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0046 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0074 0.101
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0843
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0064 0.0074
Onchocerca volvulus Deterin homolog 0.0436 0.5475 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0014 0.0024
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0158 0.0272
Echinococcus multilocularis apoptotic protease activating factor 1 0.012 0.1365 0.1365
Brugia malayi Melatonin receptor type 1A 0.0027 0.0158 0.0272
Schistosoma mansoni opsin-like receptor 0.0027 0.0158 0.0184
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0021 0.0074 0.0087
Trypanosoma brucei unspecified product 0.0026 0.0137 0.1856
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0814 1
Schistosoma mansoni hypothetical protein 0.0018 0.0041 0.0047
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.032 0.0554
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0646 0.0752
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0064 0.0865
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0158 0.0272
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Leishmania major DNA polymerase kappa, putative 0.0037 0.0288 0.3816
Leishmania major hypothetical protein, conserved 0.005 0.0446 0.5907
Echinococcus granulosus caspase 2 0.012 0.1365 0.159
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0161 0.0211
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0094 0.0266
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0021 0.0074 0.1377
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Echinococcus multilocularis calpain 5 0.002 0.0064 0.0064
Brugia malayi ORL1-like opioid receptor 0.0027 0.0158 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0736 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0158 0.0272
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0064 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0736 0.1273
Giardia lamblia DINP protein human, muc B family 0.0037 0.0288 0.5349
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2813 0.4855
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.2214 0.2214
Mycobacterium tuberculosis Conserved protein 0.0072 0.0736 0.1273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Plasmodium vivax calpain, putative 0.002 0.0064 0.0782
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0022 0.009 0.0104
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0158 0.0272
Schistosoma mansoni hypothetical protein 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0055 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0286 0.0495
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0736 0.1273
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0055 0.0094
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0009
Onchocerca volvulus 0.0027 0.0158 0.0206
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0158 0.0272
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Echinococcus granulosus neuropeptide s receptor 0.0494 0.6234 0.7265
Leishmania major GTP-binding protein, putative 0.0021 0.0067 0.0887
Onchocerca volvulus 0.0028 0.0161 0.0211
Brugia malayi hypothetical protein 0.0032 0.0217 0.0374
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0736 0.8524
Echinococcus multilocularis serotonin receptor 0.0027 0.0158 0.0158
Echinococcus multilocularis hypothetical protein 0.002 0.0064 0.0064
Schistosoma mansoni organic anion transporter 0.0028 0.0161 0.0187
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Leishmania major lanosterol synthase, putative 0.0047 0.041 0.5428
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0288 0.3914
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0094
Echinococcus granulosus neuropeptide receptor 0.0027 0.0158 0.0184
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0158 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0288 0.0498
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0177 0.0206
Brugia malayi beta-lactamase 0.0072 0.0736 0.127
Schistosoma mansoni coup transcription factor 0.002 0.0055 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0546 0.0636
Brugia malayi RE15519p 0.0027 0.0158 0.0272
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0288 0.0288
Trypanosoma brucei unspecified product 0.0026 0.0137 0.1856
Loa Loa (eye worm) calpain 0.002 0.0064 0.011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Onchocerca volvulus 0.0287 0.3533 0.6423
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0094
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0078 0.0134
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0158 0.0184
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0158 0.0184
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0021 0.0074 0.021
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0041 0.0338 0.4154
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0015 0 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Schistosoma mansoni inhibitor of apoptosis protein 0.0436 0.5475 0.638
Mycobacterium ulcerans hypothetical protein 0.0072 0.0736 0.8524
Schistosoma mansoni hypothetical protein 0.0051 0.0459 0.0535
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0158 0.0158
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0158 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0736 1
Schistosoma mansoni follistatin 0.0019 0.0046 0.0054
Brugia malayi SPARC precursor 0.0019 0.0046 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0158 0.0158
Brugia malayi GnHR receptor homolog 0.0027 0.0158 0.0272
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0464 0.0804
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0464 0.4744
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0262 0.0453
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0381 0.7073
Schistosoma mansoni myosin xvIII 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0497
Schistosoma mansoni hypothetical protein 0.0025 0.0124 0.0145
Schistosoma mansoni hypothetical protein 0.0427 0.5362 0.6249
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0158 0.0158
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0064 0.0865
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0057 0.0538 0.1523
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0562 0.0655
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Echinococcus multilocularis calpain A 0.0056 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0736 0.127
Schistosoma mansoni DNA polymerase eta 0.0037 0.0288 0.0336
Onchocerca volvulus 0.0027 0.0158 0.0206
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0191 0.0329
Leishmania major farnesyltransferase beta subunit 0.0057 0.0538 0.7131
Brugia malayi PHD-finger family protein 0.0032 0.0214 0.0369
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Echinococcus granulosus somatostatin receptor 0.0027 0.0158 0.0184
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0046 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0761 0.0887
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0499 0.0861
Echinococcus granulosus calpain A 0.002 0.0064 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0406
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0094
Trichomonas vaginalis esterase, putative 0.0072 0.0736 0.2082
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0074 0.0074
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0074 0.0128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0158 0.0184
Onchocerca volvulus 0.0027 0.0158 0.0206
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0158 0.0158
Schistosoma mansoni ap endonuclease 0.0037 0.0286 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0736 0.2082
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0057 0.0538 0.1523
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0158 0.0184
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0436 0.5475 0.9448
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0094
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0055 0.0094
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0094
Trichomonas vaginalis ran, putative 0.0021 0.0067 0.0189
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0277
Echinococcus granulosus g protein coupled receptor 0.0027 0.0158 0.0184
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0055 0.0015
Schistosoma mansoni amine GPCR 0.0027 0.0158 0.0184
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0158 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0288 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0158 0.0184
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0015 0 0.0003
Echinococcus granulosus orexin receptor type 2 0.0027 0.0158 0.0184
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0074 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0755 0.0755
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0158 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0074 0.101
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0286 0.5317
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.008
Schistosoma mansoni inositol monophosphatase 0.0045 0.0381 0.0444
Echinococcus granulosus dna polymerase eta 0.0037 0.0288 0.0336
Brugia malayi larval opioid receptor 0.0027 0.0158 0.0272
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0288 0.0814
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0814 1
Schistosoma mansoni histamine h1 receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) inositol-1 0.0045 0.0381 0.0657
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.2214 0.382
Brugia malayi Dopamine receptor 0.0027 0.0158 0.0272
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0288 0.0336
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0021 0.0074 0.0914
Loa Loa (eye worm) hypothetical protein 0.0085 0.0912 0.1574
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0021 0.0074 0.0074
Echinococcus multilocularis snurportin 1 0.0297 0.3672 0.3672
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.2214 0.382
Loa Loa (eye worm) hypothetical protein 0.0072 0.0736 0.127
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0055 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0137 0.1856
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Brugia malayi nuclear hormone receptor 0.002 0.0055 0.0094
Toxoplasma gondii ABC1 family protein 0.0072 0.0736 0.9043
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0407 0.0702
Mycobacterium ulcerans lipase LipD 0.0072 0.0736 0.8524
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0158 0.0184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3672 0.6337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0755 0.8884
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0158 0.0158
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0288 0.3914
Echinococcus granulosus calpain A 0.0056 0.0531 0.0618
Brugia malayi Dopamine receptor protein 1 0.0027 0.0158 0.0272
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0594 0.7306
Brugia malayi calpain family protein 1 0.0054 0.0499 0.0861
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0453
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0381 0.5175
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0158 0.0272
Brugia malayi hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0365 0.0365
Onchocerca volvulus 0.0028 0.0161 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0158 0.0158
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Echinococcus granulosus follistatin 0.0019 0.0046 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.0272
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0158 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0128
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0046 0.0569
Echinococcus granulosus importin subunit beta 1 0.0028 0.0163 0.019
Plasmodium vivax SET domain protein, putative 0.0037 0.0278 0.3416

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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