Detailed information for compound 1395829

Basic information

Technical information
  • TDR Targets ID: 1395829
  • Name: (E)-3-(4-methylphenyl)-2-[4-(3-oxobenzo[f]chr omen-2-yl)-1,3-thiazol-2-yl]prop-2-enenitrile
  • MW: 420.482 | Formula: C26H16N2O2S
  • H donors: 0 H acceptors: 3 LogP: 6.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1ccc(cc1)C)/c1scc(n1)c1cc2c(oc1=O)ccc1c2cccc1
  • InChi: 1S/C26H16N2O2S/c1-16-6-8-17(9-7-16)12-19(14-27)25-28-23(15-31-25)22-13-21-20-5-3-2-4-18(20)10-11-24(21)30-26(22)29/h2-13,15H,1H3/b19-12+
  • InChiKey: NKFIBRHOTFMPIV-XDHOZWIPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-methylphenyl)-2-[4-(3-oxobenzo[f]chromen-2-yl)-1,3-thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(4-methylphenyl)-2-[4-(3-oxobenzo[f]chromen-2-yl)thiazol-2-yl]prop-2-enenitrile
  • 3-(4-methylphenyl)-2-[4-(3-oxobenzo[f]chromen-2-yl)thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(4-methylphenyl)-2-[4-(3-oxo-2-benzo[f]chromenyl)-2-thiazolyl]prop-2-enenitrile
  • 3-(4-methylphenyl)-2-[4-(3-oxo-2-benzo[f]chromenyl)-2-thiazolyl]prop-2-enenitrile
  • 2-[4-(3-ketobenzo[f]chromen-2-yl)thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile
  • (E)-2-[4-(3-ketobenzo[f]chromen-2-yl)thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile
  • AH-034/10841015
  • NCGC00098346-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cysteine protease 0.0018 0.0007 0.0007
Loa Loa (eye worm) cysteine protease 0.0034 0.0028 0.013
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0043 0.0043
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0076 0.5092
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0589
Brugia malayi Cathepsin L-like precursor 0.0023 0.0014 0.0065
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Trypanosoma brucei unspecified product 0.0019 0.001 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0014 0.0143
Mycobacterium ulcerans beta-lactamase 0.011 0.0123 0.034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Brugia malayi hypothetical protein 0.175 0.2169 1
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0013 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0123 0.034
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0065 0.0301
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0007 0.0139
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0001 0.0005
Echinococcus granulosus muscleblind protein 0.0146 0.0167 0.0167
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0073 0.0076 0.1621
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0013 0.006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Onchocerca volvulus 0.011 0.0123 0.1233
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0073 0.0076 0.0201
Entamoeba histolytica hypothetical protein 0.0383 0.0464 1
Plasmodium vivax vivapain-3 0.0018 0.0007 0.0215
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0028 0.0028
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.03 1
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0007 0.0435
Loa Loa (eye worm) hypothetical protein 0.0045 0.0042 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0007 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0102 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0123 0.1348
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0028 0.0028
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0073 0.0076 0.0201
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0028 0.0587
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0032 0.2096
Onchocerca volvulus 0.0073 0.0076 0.0705
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0123 0.0568
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0185 0.0216 0.0613
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0247 0.0294 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0013 0.006
Plasmodium vivax hypothetical protein, conserved 0.011 0.0123 0.4091
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0076 0.0201
Brugia malayi RNA binding protein 0.0064 0.0065 0.0301
Schistosoma mansoni survival motor neuron protein 0.0357 0.0431 0.0431
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0013 0.0013
Entamoeba histolytica cysteine protease, putative 0.0034 0.0028 0.0587
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0252 0.03 0.03
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0032 0.0667
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0013 0.0013
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0123 0.1348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0065 0.0301
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0123 0.034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0247 0.0294 0.0842
Brugia malayi beta-lactamase family protein 0.011 0.0123 0.0568
Plasmodium vivax vivapain-1 0.0018 0.0007 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0013 0.006
Loa Loa (eye worm) ctsf protein 0.0034 0.0028 0.013
Onchocerca volvulus 0.0247 0.0294 0.3142
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0073 0.0076 0.5092
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0065 0.0065
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0073 0.0076 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0143 0.0659
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0175 0.0175
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Schistosoma mansoni peptidase Clp (S14 family) 0.0252 0.03 0.03
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0073 0.0076 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Plasmodium falciparum acyl-CoA synthetase 0.0185 0.0216 0.7197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0013 0.006
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.0131 0.0148 0.5026
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0028 0.0909
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0294 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0073 0.0076 0.2511
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0032 0.2096
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0247 0.0294 0.1356
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0028 0.013
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0028 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0043 0.0043
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0043 0.0043
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0044 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0028 0.0299
Echinococcus granulosus ferritin 0.0018 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0073 0.0076 0.0076
Brugia malayi cathepsin L-like precursor 0.0023 0.0014 0.0065
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0032 0.2096
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0065
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0013 0.0013
Onchocerca volvulus 0.0034 0.0028 0.017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0028 0.0909
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0076 0.0201
Plasmodium falciparum flap endonuclease 1 0.0028 0.002 0.0634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0097 0.0097
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.011 0.0123 0.034
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0028 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0073 0.0076 0.0201
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.002 0.0646
Loa Loa (eye worm) hypothetical protein 0.0263 0.0314 0.1446
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0013 0.0013
Brugia malayi beta-lactamase family protein 0.011 0.0123 0.0568
Leishmania major hypothetical protein, conserved 0.011 0.0123 0.417
Leishmania major DNA polymerase eta, putative 0.0045 0.0042 0.139
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0032 0.0032
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0073 0.0076 0.0201
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.002 0.1286
Toxoplasma gondii propionate-CoA ligase 0.0073 0.0076 0.2511
Echinococcus granulosus flap endonuclease 1 0.0028 0.002 0.002
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0032 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0001 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0123 0.034
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0035
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.005 0.1627
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0013 0.006
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0123 0.034
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.0435
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0357 0.0431 0.1986
Toxoplasma gondii hypothetical protein 0.0087 0.0094 0.3103
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0192 0.054
Leishmania major DNA polymerase eta, putative 0.0032 0.0025 0.0818
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0148 1
Schistosoma mansoni flap endonuclease-1 0.0025 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0028 0.0028
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0073 0.0076 0.0076
Echinococcus granulosus expressed protein 0.0018 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0252 0.03 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0123 0.0568
Onchocerca volvulus 0.0073 0.0076 0.0705
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0123 0.0123
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.001
Leishmania major cathepsin L-like protease 0.0131 0.0148 0.5026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Plasmodium vivax SET domain protein, putative 0.0093 0.0102 0.3368
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0073 0.0076 0.0201
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0076 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0013 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0123 0.1348
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0007 0.0031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Brugia malayi Muscleblind-like protein 0.0146 0.0167 0.0771
Toxoplasma gondii ABC1 family protein 0.011 0.0123 0.4091
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0073 0.0076 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Loa Loa (eye worm) inositol-1 0.0037 0.0032 0.0147
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0094 0.0253
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0146 0.0167 0.0771
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0028 0.017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0043 0.0043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0123 0.034
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0013 0.0013
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0252 0.03 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0203 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0435
Echinococcus multilocularis cysteine protease 0.0034 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Loa Loa (eye worm) RNA binding protein 0.0064 0.0065 0.0301
Echinococcus granulosus cathepsin L 0.0018 0.0007 0.0007
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0027 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0013 0.006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0013 0.006
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0076 0.5092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0013 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0045
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0123 0.8296
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0076 0.0827
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0073 0.0076 0.0351
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0013 0.006
Schistosoma mansoni hypothetical protein 0.0383 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0014 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0102 0.0102
Brugia malayi nuclear receptor NHR-88 0.0022 0.0013 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0123 0.1348
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0294 0.0842
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0076 0.0201
Leishmania major cathepsin L-like protease 0.0034 0.0028 0.0926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Onchocerca volvulus 0.011 0.0123 0.1233
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0192 0.054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0073 0.0076 0.0351
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0013 0.006
Brugia malayi hypothetical protein 0.0383 0.0464 0.2138
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Onchocerca volvulus 0.0034 0.0028 0.017
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0028 0.0926
Brugia malayi Flap endonuclease-1 0.0028 0.002 0.0092
Loa Loa (eye worm) hypothetical protein 0.0093 0.0102 0.0469
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0102 0.0102
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Brugia malayi Inositol-1 0.0037 0.0032 0.0147
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0093 0.0102 0.0991
Trichomonas vaginalis antibiotic synthetase, putative 0.0073 0.0076 0.0827
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.0294 0.6334
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0044 0.1448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0013 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0123 0.8296
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.005 0.0536
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0073 0.0076 0.5092
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0174 0.0203 0.0203
Giardia lamblia DINP protein human, muc B family 0.0019 0.001 0.2005
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.002 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Echinococcus multilocularis tumor protein p63 0.1797 0.2227 0.2227
Loa Loa (eye worm) hypothetical protein 0.0037 0.0031 0.0144
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0007 0.0435
Schistosoma mansoni hypothetical protein 0.0152 0.0175 0.0175
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0042 0.2765
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0013 0.006
Echinococcus multilocularis 0.0013 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.011 0.0123 0.034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.0294 0.0842
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0294 0.1356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0102 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0013 0.0013
Echinococcus multilocularis expressed protein 0.0018 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0123 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0247 0.0294 0.0842
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0065
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0123 0.034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0034 0.0028 0.0926
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0203 0.0576
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0073 0.0076 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0032 0.0835
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0013 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0013 0.006
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0007 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0013 0.006
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0007 0.0215
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0014 0.0065
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0192 0.0192
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0589
Entamoeba histolytica acyl-CoA synthetase, putative 0.0247 0.0294 0.6334
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Brugia malayi TAR-binding protein 0.0064 0.0065 0.0301
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2746 0.3412 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0073 0.0076 0.0201
Brugia malayi Probable ClpP-like protease 0.0252 0.03 0.1382
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0076 0.256
Echinococcus granulosus dna polymerase eta 0.0045 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0065 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0052 0.0242
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.0294 0.1356
Loa Loa (eye worm) hypothetical protein 0.175 0.2169 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0032 0.0032
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.002 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0294 0.1356
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0013 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0013 0.006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0027 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0013 0.0013
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0028 0.013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0192 0.054
Schistosoma mansoni acetyl-CoA synthetase 0.0073 0.0076 0.0076
Brugia malayi steroid hormone receptor 0.0022 0.0013 0.006
Leishmania major cathepsin L-like protease 0.0034 0.0028 0.0926
Echinococcus granulosus tumor protein p63 0.1797 0.2227 0.2227
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0013 0.0013
Mycobacterium ulcerans transcriptional regulator 0.2746 0.3412 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0076 0.256
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0143 0.0659
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0247 0.0294 0.0842
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0028 0.017
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0032 0.1053
Leishmania major cathepsin L-like protease 0.0131 0.0148 0.5026
Echinococcus granulosus cathepsin l1 0.0023 0.0014 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0065
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0013 0.0013
Entamoeba histolytica Flap nuclease, putative 0.0028 0.002 0.0409
Loa Loa (eye worm) hypothetical protein 0.0247 0.0294 0.1356
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0052 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0383 0.0464 0.0464
Trypanosoma cruzi cruzipain precursor, putative 0.0131 0.0148 1
Echinococcus multilocularis cathepsin L 0.0018 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0383 0.0464 1
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0123 0.034
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Onchocerca volvulus 0.0034 0.0028 0.017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0247 0.0294 0.0842
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0013 0.0013
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0175 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0043 0.02
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0014 0.0281
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.0296
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0042 0.2765
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0034 0.0028 0.017
Echinococcus multilocularis GPCR, family 2 0.0017 0.0007 0.0007
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0028 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0589
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0073 0.0076 0.0201
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0045
Brugia malayi Pre-SET motif family protein 0.065 0.0796 0.3669
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0096
Mycobacterium tuberculosis Conserved protein 0.011 0.0123 0.034
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0028 0.1843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0013 0.006
Mycobacterium ulcerans hypothetical protein 0.0247 0.0294 0.0842
Schistosoma mansoni hypothetical protein 0.0357 0.0431 0.0431
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.005 0.1627
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0052 0.0242
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0023 0.0014 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0076 0.0201
Onchocerca volvulus 0.0263 0.0314 0.336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0071
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0294 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0028 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0013 0.006
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.002 0.4379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0203 0.0576
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0123 0.034
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0028 0.0299
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0094 0.3103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0013 0.0013
Mycobacterium leprae conserved hypothetical protein 0.011 0.0123 0.034
Onchocerca volvulus 0.0073 0.0076 0.0705
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0007 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0383 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0185 0.0216 0.0996
Loa Loa (eye worm) hypothetical protein 0.0185 0.0216 0.0996
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0042 0.0193
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0028 0.0028
Plasmodium vivax acyl-CoA synthetase, putative 0.0185 0.0216 0.7197
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0065 0.0301
Onchocerca volvulus 0.0739 0.0908 1
Echinococcus multilocularis cysteine protease 0.0034 0.0028 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0123 0.8296
Loa Loa (eye worm) acetyltransferase 0.0175 0.0204 0.094
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Echinococcus multilocularis dna polymerase eta 0.0045 0.0042 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0094 0.3103
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0204 0.0204
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 0.0859
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0073 0.0076 0.0201
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0076 0.5092
Onchocerca volvulus 0.011 0.0123 0.1233
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0007 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.0102 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0102 0.3368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0043
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0073 0.0076 0.2511
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0001 0.0001
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0185 0.0216 0.0996
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0123 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0031 0.0144
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0032 0.034
Brugia malayi MH2 domain containing protein 0.0126 0.0143 0.0659
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0096
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.001
Brugia malayi nuclear hormone receptor 0.0022 0.0013 0.006
Mycobacterium ulcerans TetR family transcriptional regulator 0.2746 0.3412 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0216 0.0996
Onchocerca volvulus 0.0023 0.0014 0.0012
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0073 0.0076 0.0201
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0013 0.006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0028 0.0909
Leishmania major acetyl-CoA synthetase, putative 0.0073 0.0076 0.256
Trichomonas vaginalis esterase, putative 0.011 0.0123 0.1348
Trichomonas vaginalis set domain proteins, putative 0.0739 0.0908 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0589
Mycobacterium leprae Probable lipase LipE 0.011 0.0123 0.034
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0294 0.0842
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0247 0.0294 0.0842
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0013 0.006
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Mycobacterium tuberculosis Conserved protein 0.011 0.0123 0.034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.0296
Toxoplasma gondii cathepsin CPL 0.0034 0.0028 0.0909
Onchocerca volvulus 0.0034 0.0028 0.017
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0025 0.1628
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0032 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0123 0.1348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Loa Loa (eye worm) hypothetical protein 0.0252 0.03 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0435
Trypanosoma brucei unspecified product 0.0013 0.0002 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2746 0.3412 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0185 0.0216 0.0996
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0025 0.0803
Brugia malayi Pre-SET motif family protein 0.0093 0.0102 0.0469
Mycobacterium tuberculosis Conserved protein 0.011 0.0123 0.034
Echinococcus granulosus cathepsin l1 0.0034 0.0028 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0032 0.1033
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0063 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0383 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0065 0.0065
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0073 0.0076 0.0201
Schistosoma mansoni coup transcription factor 0.0022 0.0013 0.0013
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0094 0.295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0134 0.904
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0076 0.0201
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Onchocerca volvulus 0.0357 0.0431 0.467
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0032 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Echinococcus multilocularis survival motor neuron protein 1 0.175 0.2169 0.2169
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0073 0.0076 0.0201
Echinococcus granulosus tar DNA binding protein 0.0064 0.0065 0.0065
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Loa Loa (eye worm) beta-lactamase 0.011 0.0123 0.0568
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0006
Brugia malayi beta-lactamase 0.011 0.0123 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Onchocerca volvulus 0.0034 0.0028 0.017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0123 0.034
Schistosoma mansoni DNA polymerase eta 0.0045 0.0042 0.0042
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0247 0.0294 0.0842
Loa Loa (eye worm) hypothetical protein 0.0073 0.0076 0.0351
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0073 0.0076 0.2511
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 0.0859
Brugia malayi AMP-binding enzyme family protein 0.0247 0.0294 0.1356
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0185 0.0216 0.0613
Echinococcus multilocularis ferritin 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0013 0.006
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0203 0.0203
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0204 0.094
Echinococcus granulosus survival motor neuron protein 1 0.175 0.2169 0.2169
Entamoeba histolytica hypothetical protein 0.0383 0.0464 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 1
Echinococcus multilocularis muscleblind protein 0.0146 0.0167 0.0167
Leishmania major cathepsin L-like protease 0.0034 0.0028 0.0926
Loa Loa (eye worm) hypothetical protein 0.011 0.0123 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0148 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0073 0.0076 0.0201
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0252 0.03 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.005 0.0536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0247 0.0294 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2746 0.3412 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0247 0.0294 0.0842
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0013 0.006
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.002 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0065 0.0065
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0073 0.0076 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0076 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0113 0.7633
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0073 0.0076 0.5092
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0706 0.0866 0.2522
Echinococcus multilocularis flap endonuclease 1 0.0028 0.002 0.002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.001 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0043 0.02
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.002 0.1286
Mycobacterium ulcerans acetyl-CoA synthetase 0.0073 0.0076 0.0201
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0252 0.03 0.0859
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.065 0.0796 0.3669
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.001 0.0006
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0073 0.0076 0.2511
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.006
Schistosoma mansoni transcription factor LCR-F1 0.0383 0.0464 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0028 0.0299
Loa Loa (eye worm) fibroinase 0.0034 0.0028 0.013
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0044 0.0935
Echinococcus granulosus GPCR family 2 0.0017 0.0007 0.0007
Schistosoma mansoni inositol monophosphatase 0.0037 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0139
Loa Loa (eye worm) hypothetical protein 0.0146 0.0167 0.0771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Onchocerca volvulus 0.0073 0.0076 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0589
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.005 0.1627
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0008
Loa Loa (eye worm) oxidoreductase 0.0073 0.0076 0.0351
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0187
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.0435
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0589
Trichomonas vaginalis ferritin, putative 0.0018 0.0008 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0052 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.0034 0.0028 0.0926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0028 0.0299
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.013
Plasmodium vivax unspecified product 0.0018 0.0007 0.0215
Plasmodium vivax vivapain-2 0.0034 0.0028 0.0909
Brugia malayi Cathepsin L-like precursor 0.0034 0.0028 0.013
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.002 0.0634
Schistosoma mansoni cellular tumor antigen P53 0.0263 0.0314 0.0314
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.03 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0139
Schistosoma mansoni hypothetical protein 0.0037 0.0031 0.0031
Brugia malayi ecdysteroid receptor 0.0022 0.0013 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0002 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0076 0.0351
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0148 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0175 0.0203 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0148 1
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0203 0.0203
Entamoeba histolytica acyl-coA synthetase, putative 0.0247 0.0294 0.6334
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0589
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0031
Onchocerca volvulus 0.0034 0.0028 0.017
Plasmodium vivax vivapain-2 0.0034 0.0028 0.0909

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.