Detailed information for compound 139601

Basic information

Technical information
  • TDR Targets ID: 139601
  • Name: ethyl 4-amino-6-methyl-1-pent-4-ynylpyrazolo[ 3,4-b]pyridine-5-carboxylate
  • MW: 286.329 | Formula: C15H18N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)nc2c(c1N)cnn2CCCC#C
  • InChi: 1S/C15H18N4O2/c1-4-6-7-8-19-14-11(9-17-19)13(16)12(10(3)18-14)15(20)21-5-2/h1,9H,5-8H2,2-3H3,(H2,16,18)
  • InChiKey: BNWNSVFBDMBIOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-amino-6-methyl-1-pent-4-ynyl-pyrazolo[3,4-b]pyridine-5-carboxylate
  • 4-amino-6-methyl-1-pent-4-ynyl-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester
  • ethyl 4-azanyl-6-methyl-1-pent-4-ynyl-pyrazolo[3,4-b]pyridine-5-carboxylate
  • 4-amino-6-methyl-1-pent-4-ynyl-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
  • ethyl 4-amino-6-methyl-1-pent-4-ynylpyrazolo[4,5-e]pyridine-5-carboxylate
  • ethyl 4-amino-6-methyl-1-pent-4-ynyl-pyrazolo[4,5-e]pyridine-5-carboxylate
  • 4-amino-6-methyl-1-pent-4-ynyl-5-pyrazolo[4,5-e]pyridinecarboxylic acid ethyl ester
  • 4-amino-6-methyl-1-pent-4-ynyl-pyrazolo[4,5-e]pyridine-5-carboxylic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0156 0.0375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0396 0.0392
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0588 0.4066 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.0037 0.0083
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.0037 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0186 0.1202 0.1199
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0602 0.4913
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0123 0.0754 0.1854
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0279 0.0696
Onchocerca volvulus 0.0022 0.0036 0.0166
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.0037 0.0034
Brugia malayi hypothetical protein 0.0021 0.0024 0.005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0086 0.0491 0.1207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0582 0.0578
Entamoeba histolytica hypothetical protein 0.0186 0.1202 1
Brugia malayi Cation transporter family protein 0.0023 0.0037 0.0083
Trypanosoma cruzi GMP reductase 0.0588 0.4066 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0022 0.0036 0.008
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0396 0.0921
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0973
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0754 0.1839
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0051 0.0068
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0054 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0051 0.0109
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0218 0.0214
Loa Loa (eye worm) cytochrome P450 family protein 0.0235 0.1553 0.3814
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0914 0.0911
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Onchocerca volvulus Putative nachr subunit 0.0023 0.0037 0.0174
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0086 0.0491 0.1207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Schistosoma mansoni cytochrome P450 0.0086 0.0491 0.0487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Onchocerca volvulus 0.0023 0.0037 0.0174
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0164 0.1045 0.2565
Brugia malayi Probable ClpP-like protease 0.0164 0.1045 0.2565
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0396 0.0991
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0147 0.0353
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0086 0.0491 0.1207
Leishmania major inosine-5-monophosphate dehydrogenase 0.0588 0.4066 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0086 0.0491 0.1207
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0288 0.0285
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0024 0.0051
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0004 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0582 0.0578
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0164 0.1045 0.2528
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0036 0.008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0103 0.0611 0.0607
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0037 0.0034
Brugia malayi ecdysone receptor 0.0019 0.0008 0.0012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0051 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0156 0.0152
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0008 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0396 0.0392
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0288 0.07
Schistosoma mansoni DNA ligase IV 0.0021 0.0024 0.002
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0218 0.0527
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 0.2558
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0396 0.6339
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0086 0.0491 0.1192
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.0973 0.2386
Schistosoma mansoni topbp1 0.0021 0.0024 0.002
Leishmania major cytochrome p450-like protein 0.0154 0.0973 0.2386
Toxoplasma gondii IMP dehydrogenas 0.0588 0.4066 1
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.1778 0.1775
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.0037 0.0034
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0754 0.075
Onchocerca volvulus 0.0023 0.0037 0.0174
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0086 0.0491 0.1207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0396 0.0958
Toxoplasma gondii cytochrome p450 superfamily protein 0.0086 0.0491 0.12
Brugia malayi hypothetical protein 0.0186 0.1202 0.295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0955 0.2343
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.1778 0.1775
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0147 0.0353
Brugia malayi Cytochrome P450 family protein 0.0154 0.0973 0.2386
Schistosoma mansoni coup transcription factor 0.0039 0.0156 0.0152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0147 0.0143
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0588 0.4066 1
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.032 0.2157 0.5279
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0086 0.0491 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0156 0.0375
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0103 0.0611 1
Schistosoma mansoni hypothetical protein 0.0186 0.1202 0.1199
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0037 0.0034
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0588 0.4066 0.4063
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0506 0.0503
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Brugia malayi intermediate filament protein 0.0024 0.0047 0.0108
Echinococcus granulosus cytochrome P450 2K1 0.0086 0.0491 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0147 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0611 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0582 0.1423
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0054 0.0074
Mycobacterium leprae Possible regulatory protein 0.0022 0.0036 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0156 0.0375
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0024 0.005
Brugia malayi Cytochrome P450 family protein 0.0154 0.0973 0.2386
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0209
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0164 0.1045 0.2565
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0024 0.0021
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0086 0.0491 0.1192
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0051 0.0126
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0086 0.0491 0.1192
Schistosoma mansoni hypothetical protein 0.0054 0.0264 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0156 0.0375
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0147 0.0143
Brugia malayi Cytochrome P450 family protein 0.0235 0.1553 0.3814
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0037 0.0034
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 0.2528
Leishmania major protein kinase, putative 0.0022 0.0036 0.008
Leishmania major cytochrome p450-like protein 0.0086 0.0491 0.12
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0582 0.0578
Toxoplasma gondii exonuclease III APE 0.0038 0.0147 0.0353
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0054 0.0123
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0086 0.0491 0.1192
Trypanosoma brucei cytochrome P450, putative 0.0154 0.0973 0.2386
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0022 0.0036 0.0032
Onchocerca volvulus Putative GMP reductase 0.0253 0.1682 1
Brugia malayi hypothetical protein 0.0289 0.1935 0.4754
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Brugia malayi nuclear hormone receptor 0.0019 0.0008 0.0012
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0008 0.0005
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0086 0.0491 0.1192
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.0794
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0086 0.0491 0.1192
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0156 0.0152
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0147 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0103 0.0611 0.1494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0164 0.1045 0.1042
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0396 0.0973
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0396 0.0966
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0123 0.0754 0.1846
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.0037 0.0083
Brugia malayi nuclear receptor RXR 0.0021 0.0024 0.0051
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.3182 0.3179
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0086 0.0491 0.1207
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0279 0.0696
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0086 0.0491 0.1207
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0289 0.1935 0.4754
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0614 0.1503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0086 0.0491 0.1192
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0118
Schistosoma mansoni peptidase Clp (S14 family) 0.0164 0.1045 0.1042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0253 0.1682 0.4131
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0008 0.0005
Mycobacterium leprae putative cytochrome p450 0.0086 0.0491 0.1156
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0008 0.0012
Brugia malayi CHE-14 protein 0.0044 0.0188 0.0454
Echinococcus granulosus intermediate filament protein 0.0024 0.0047 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0156 0.0375
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0022 0.0036 0.0209
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0054 0.0127
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0123 0.0754 0.075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0156 0.0152
Echinococcus multilocularis protein patched 0.0044 0.0188 0.0185
Onchocerca volvulus 0.0021 0.0024 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0156 0.0375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0051
Echinococcus multilocularis tumor protein p63 0.068 0.4717 0.4715
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0156 0.0152
Onchocerca volvulus 0.0023 0.0037 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0396 0.0966
Brugia malayi Cation transporter family protein 0.0023 0.0037 0.0083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0218 0.0527
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.0037 0.0034
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0024 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0086 0.0491 0.1207
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0037 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0086 0.0491 0.1207
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.0794
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0054 0.0448
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0288 0.0285
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.0037 0.0034
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0024 0.005
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0602 0.0599
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0268 0.1785 0.4357
Schistosoma mansoni hypothetical protein 0.0048 0.0218 0.0214
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0288 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0156 0.0375
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0108 0.0643 0.1532
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0024 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0156 0.0882
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 0.2632
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0147 0.0361
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0086 0.0491 0.1192
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0164 0.1045 0.2565
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0103 0.0611 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0156 0.0375
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0588 0.4066 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0086 0.0491 0.1192
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Schistosoma mansoni ap endonuclease 0.0038 0.0147 0.0143
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0147 0.0353
Echinococcus granulosus lamin dm0 0.0024 0.0047 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0086 0.0491 0.1207
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0047 0.0108
Chlamydia trachomatis DNA ligase 0.0021 0.0024 0.0159
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0103 0.0611 0.0607
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0326 0.0794
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0156 0.0152
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0086 0.0491 0.1192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0009
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.0037 0.0083
Trypanosoma cruzi cytochrome P450, putative 0.0154 0.0973 0.2386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0582 0.1423
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0156 0.0375
Trichomonas vaginalis adenylate cyclase, putative 0.0022 0.0036 0.0209
Echinococcus multilocularis nibrin 0.0021 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0051 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0582 0.0578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0008 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0396 0.0966
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0156 0.0375
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0156 0.0152
Brugia malayi jmjC domain containing protein 0.0058 0.0288 0.07
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0156 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0156 0.0375
Brugia malayi GMP reductase 0.0253 0.1682 0.4131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0574 0.3962 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0008 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0156 0.0152
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0156 0.0152
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0218 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0118
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0588 0.4066 1
Brugia malayi Cytochrome P450 family protein 0.0086 0.0491 0.12
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0103 0.0611 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.0306 0.2054 0.5048
Brugia malayi bHLH-PAS transcription factor 0.0064 0.0331 0.0805
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0037 0.0083
Loa Loa (eye worm) LGC-31 protein 0.0023 0.0037 0.0083
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0588 0.4066 1
Brugia malayi nuclear receptor NHR-67 0.0019 0.0008 0.0012
Echinococcus multilocularis protein dispatched 1 0.005 0.0232 0.0229
Schistosoma mansoni nuclear receptor 0.0019 0.0008 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0147 0.0362
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Loa Loa (eye worm) hypothetical protein 0.0102 0.0602 0.1474
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0086 0.0491 0.1192
Schistosoma mansoni zinc finger protein 0.0019 0.0008 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0051 0.0109
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0574 0.3962 0.9746
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0103 0.0611 0.1494
Brugia malayi PAS domain containing protein 0.0086 0.049 0.1197
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0588 0.4066 1
Onchocerca volvulus 0.0054 0.0264 0.153
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0054 0.0123
Loa Loa (eye worm) hypothetical protein 0.0068 0.0358 0.0873
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0311 0.2092 0.2089
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0037 0.0034
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.0037 0.0034
Mycobacterium leprae Conserved hypothetical protein 0.0086 0.0491 0.1156
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0147 0.2097
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0506 0.1238
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0154 0.0973 0.2379
Brugia malayi beta-lactamase family protein 0.0073 0.0396 0.0966
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0054 0.0115
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0024 0.005
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0024 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0264 0.0642
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.0527
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.0973 0.2386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0086 0.0491 0.1207
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0051 0.0235
Entamoeba histolytica hypothetical protein 0.0186 0.1202 1
Brugia malayi conserved hypotetical protein 0.0019 0.0008 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0156 0.0152
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0506 0.0503
Loa Loa (eye worm) hypothetical protein 0.0103 0.0611 0.1494
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0086 0.0491 0.1207
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0396 0.0973
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0156 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0156 0.0375
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.3182 0.3179
Brugia malayi follicle stimulating hormone receptor 0.0497 0.3417 0.8404
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0103 0.0611 0.1494
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0051 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0086 0.0491 0.1207
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0054 0.0293
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0156 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0024 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0186 0.1202 0.1199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0288 0.0285
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0009
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0008 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0464 0.3182 0.3179
Trypanosoma cruzi cytochrome P450, putative 0.0154 0.0973 0.2386
Schistosoma mansoni ap endonuclease 0.0038 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0108
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0054 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0156 0.0375
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Brugia malayi beta-lactamase family protein 0.0073 0.0396 0.0966
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0156 0.0375
Brugia malayi ecdysteroid receptor 0.0039 0.0156 0.0375
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0086 0.0491 0.12
Loa Loa (eye worm) GMP reductase 0.0253 0.1682 0.4131
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0086 0.0491 0.1207
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0103 0.0611 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0036 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Loa Loa (eye worm) cytochrome P450 0.0086 0.0491 0.12
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0218 0.0527
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0086 0.0491 0.12
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0086 0.0491 0.1207
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0008 0.0012
Onchocerca volvulus 0.0073 0.0396 0.2315
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0973
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0173
Echinococcus multilocularis aryl hydrocarbon receptor 0.0022 0.0036 0.0032
Echinococcus granulosus GPCR family 2 0.0048 0.0218 0.0214
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0057 0.0279 0.0632
Trichomonas vaginalis guanylate cyclase, putative 0.0022 0.0036 0.0209
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0506 0.0503
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0588 0.4066 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0037 0.0083
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0588 0.4066 1
Leishmania major hypothetical protein, conserved 0.0073 0.0396 0.0966
Echinococcus multilocularis ubiquitin specific protease 41 0.0103 0.0611 0.0607
Brugia malayi hypothetical protein 0.0021 0.0024 0.005
Onchocerca volvulus 0.0099 0.0585 0.3446
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0156 0.0152
Entamoeba histolytica hypothetical protein 0.0186 0.1202 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0103 0.0611 0.1494
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0287 0.0698
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0188 0.0454
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0022 0.0036 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0156 0.0152
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0164 0.1045 0.2632
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0218 0.0214
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0022 0.0036 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.0794
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0588 0.4066 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0022 0.0036 0.008
Onchocerca volvulus 0.0023 0.0037 0.0174
Schistosoma mansoni hypothetical protein 0.0048 0.0218 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0051 0.0109
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0156 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0582 0.0578
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0024 0.0051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.3194 0.7856
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0156 0.0375
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0054 0.0074
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0008 0.0005
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0253 0.1682 0.4131
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0008 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0396 0.0958
Brugia malayi hypothetical protein 0.0019 0.0008 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0156 0.0152
Echinococcus granulosus aryl hydrocarbon receptor 0.0022 0.0036 0.0032
Entamoeba histolytica hypothetical protein 0.0186 0.1202 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.0396 0.0958
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0156 0.0375
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0396 0.0973
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.0037 0.0083
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0086 0.0491 0.1192
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0147 0.0344
Onchocerca volvulus 0.0023 0.0037 0.0174
Brugia malayi jmjC domain containing protein 0.0058 0.0288 0.07
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0156 0.0375
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.0794
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0108 0.0643 0.1581
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0086 0.0491 0.1207
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0156 0.0152
Echinococcus granulosus peptidase Clp S14 family 0.0108 0.0643 0.0639
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0396 0.0973
Entamoeba histolytica hypothetical protein 0.0025 0.0054 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0588 0.4066 0.4063
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0037 0.0034
Schistosoma mansoni single-minded 0.0086 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0086 0.0491 0.1192
Echinococcus multilocularis musashi 0.0024 0.0047 0.0044
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0396 0.0973
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0037 0.0034
Echinococcus multilocularis transfer RNA-Lys 0.0064 0.0331 0.0327
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.0037 0.0083
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0311 0.2092 0.2089
Schistosoma mansoni lamin 0.0024 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Echinococcus multilocularis expressed conserved protein 0.0096 0.0558 0.0555
Brugia malayi beta-lactamase 0.0073 0.0396 0.0966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Schistosoma mansoni hypothetical protein 0.0104 0.0614 0.0611
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0008 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0008 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0047 0.0108
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0585 0.0582
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Echinococcus multilocularis lamin dm0 0.0024 0.0047 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0156 0.0152
Schistosoma mansoni topbp1 0.0021 0.0024 0.002
Mycobacterium ulcerans beta-lactamase 0.0073 0.0396 0.0958
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0009
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0602 0.0599
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0188 0.0454
Echinococcus multilocularis microtubule associated protein 2 0.1421 1 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0188 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0326 0.0794
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0022 0.0036 0.0209
Echinococcus multilocularis nAChR subunit 0.0023 0.0037 0.0034
Schistosoma mansoni microtubule-associated protein tau 0.1421 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0209
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0396 0.0973
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0008 0.0005
Leishmania major cytochrome p450-like protein 0.0086 0.0491 0.12
Echinococcus granulosus nibrin 0.0021 0.0024 0.002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0147 0.1045
Mycobacterium tuberculosis Conserved protein 0.0073 0.0396 0.0973
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0051
Onchocerca volvulus 0.0023 0.0037 0.0174
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0188 0.0185
Echinococcus granulosus lamin 0.0024 0.0047 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0497 0.3417 0.8404
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.6339
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0024 0.0051
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0008 0.0005
Leishmania major guanosine monophosphate reductase 0.0588 0.4066 1
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0037 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0582 0.0578
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0103 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0024 0.002
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0008 0.0012
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0036 0.008
Brugia malayi nuclear receptor NHR-88 0.0019 0.0008 0.0012
Loa Loa (eye worm) beta-lactamase 0.0073 0.0396 0.0966
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0086 0.0491 0.12
Loa Loa (eye worm) hypothetical protein 0.0306 0.2054 0.5048
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 0.2558
Brugia malayi hypothetical protein 0.0267 0.1778 0.4368
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0123 0.0754 0.1846
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0123 0.0754 0.1839
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0186 0.1202 0.1199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0156 0.0882
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0103 0.0611 0.0607
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0054 0.0123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0288 0.0285
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0164 0.1045 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0156 0.0375
Echinococcus granulosus single minded 2 0.0064 0.0331 0.0327
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.0037 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0396 0.0966
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0037 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0086 0.0491 0.1207
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0008 0.0012
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0103 0.0611 0.4982
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0103 0.0611 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0147 0.0305
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0008 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0086 0.0491 0.1207
Brugia malayi nuclear receptor NHR-88 0.0039 0.0156 0.0375
Loa Loa (eye worm) DR-78 0.0019 0.0008 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0396 0.0392
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0022 0.0036 0.0209
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0051 0.0109
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0645 0.158
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Trypanosoma cruzi GMP reductase 0.0588 0.4066 1
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.3182 0.3179
Onchocerca volvulus 0.0024 0.0047 0.0233
Schistosoma mansoni aryl hydrocarbon receptor 0.0086 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0151 0.0955 0.2343
Toxoplasma gondii ABC1 family protein 0.0073 0.0396 0.0966
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.0037 0.0034
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0396 0.0973
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0024 0.002
Onchocerca volvulus 0.0073 0.0396 0.2315
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.0037 0.0034
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0173
Schistosoma mansoni patched 1 0.0044 0.0188 0.0185
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0147 0.1205
Onchocerca volvulus 0.0088 0.0506 0.2976
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0209
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0156 0.0152
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0147 0.2097
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0008 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0051 0.0118
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.032 0.2157 0.5306
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0036 0.0277
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0037 0.0083
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0037 0.0083
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0022 0.0036 0.0209
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0051 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0156 0.0375
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0086 0.0491 0.1192
Brugia malayi hypothetical protein 0.0021 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0156 0.0152
Toxoplasma gondii hypothetical protein 0.0057 0.0279 0.0679
Trichomonas vaginalis esterase, putative 0.0073 0.0396 0.6339
Mycobacterium ulcerans lipase LipD 0.0073 0.0396 0.0958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Mycobacterium ulcerans hypothetical protein 0.0025 0.0051 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0024 0.005
Brugia malayi hypoxia-induced factor 1 0.0267 0.1775 0.4361
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0156 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Loa Loa (eye worm) hypothetical protein 0.0073 0.0396 0.0966
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0037 0.0034
Brugia malayi tailless protein 0.0019 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0051
Brugia malayi nuclear receptor RXR 0.0019 0.0008 0.0012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0108 0.0643 0.1581
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.6339
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0103 0.0611 0.1494
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0051 0.0118
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0602 0.1474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.023 0.0557
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0051 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0051 0.0126
Brugia malayi hypothetical protein 0.0019 0.0008 0.0012
Brugia malayi cytochrome P450 0.0086 0.0491 0.12
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0396 0.6339
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0147 0.2097
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0037 0.0034
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0086 0.0491 0.1192
Schistosoma mansoni intermediate filament proteins 0.0024 0.0047 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0156 0.0152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0156 0.0152
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.0037 0.0083
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0086 0.0491 0.1192
Echinococcus multilocularis GPCR, family 2 0.0048 0.0218 0.0214
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0086 0.0491 0.1192
Echinococcus granulosus expressed conserved protein 0.0096 0.0558 0.0555
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0164 0.1045 0.1042
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0008 0.0005
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0037 0.0083
Brugia malayi nuclear hormone receptor 0.0039 0.0156 0.0375
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0188 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.0037 0.0083
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0156 0.0375
Loa Loa (eye worm) hypothetical protein 0.0099 0.0585 0.1431
Brugia malayi steroid hormone receptor 0.0039 0.0156 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0008 0.0005
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0086 0.0491 0.1192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0156 0.0375
Schistosoma mansoni hypothetical protein 0.0048 0.0218 0.0214
Trypanosoma brucei GMP reductase 0.0588 0.4066 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0614 0.1503
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0024 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0268 0.1785 0.438
Mycobacterium leprae Probable lipase LipE 0.0073 0.0396 0.0921
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0614 0.061
Onchocerca volvulus 0.0064 0.0331 0.1925
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0051 0.0109
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0588 0.4066 0.4063
Loa Loa (eye worm) CYP4Cod1 0.0154 0.0973 0.2386
Brugia malayi DKFZp564C0469 protein 0.0021 0.0024 0.005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0123 0.0754 0.075
Onchocerca volvulus 0.0039 0.0156 0.0882
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0288 0.0285
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypoxia-induced factor 1 0.0267 0.1775 0.4361
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0574 0.3962 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0955 0.2343
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0147 0.0362
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0018
Echinococcus granulosus tumor protein p63 0.068 0.4717 0.4715
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0054 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Leishmania major protein kinase, putative 0.0022 0.0036 0.008
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0086 0.0491 0.1207
Leishmania major cathepsin L-like protease 0.0063 0.0326 0.0794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0582 0.0578
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0036 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0396 0.6339
Brugia malayi hypothetical protein 0.0021 0.0024 0.0051
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0024 0.0021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0051 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0156 0.0152
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0086 0.0491 0.1192
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0375
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0012
Onchocerca volvulus 0.0022 0.0036 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0051 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0288 0.0285
Echinococcus multilocularis peptidase Clp (S14 family) 0.0108 0.0643 0.0639
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.01
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0008 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0024 0.0051
Echinococcus granulosus ubiquitin specific protease 41 0.0103 0.0611 0.0607
Loa Loa (eye worm) hypothetical protein 0.0088 0.0506 0.1238
Schistosoma mansoni lamin 0.0024 0.0047 0.0044
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0086 0.0491 0.12
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.0037 0.0083
Onchocerca volvulus 0.0024 0.0047 0.0233
Schistosoma mansoni nAChR subunit 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0267 0.1778 0.4368
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0955 0.2343
Mycobacterium ulcerans putative regulatory protein 0.0064 0.0331 0.0797
Schistosoma mansoni hypothetical protein 0.0048 0.0218 0.0214
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0156 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0051 0.0118
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0279 0.2501
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0037 0.0034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0051 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0147 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0156 0.0375
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0914 0.0911
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0037 0.0034
Onchocerca volvulus 0.0025 0.0051 0.0257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0024 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0156 0.0152
Brugia malayi Cation transporter family protein 0.0023 0.0037 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0326 0.0794
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0396 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0188 0.28
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0037 0.0083
Schistosoma mansoni nuclear receptor 0.0019 0.0008 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0047 0.0108
Echinococcus multilocularis lamin 0.0024 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0156 0.0152
Schistosoma mansoni survival motor neuron protein 0.0054 0.0264 0.0261
Trichomonas vaginalis guanylate cyclase, putative 0.0022 0.0036 0.0209
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0156 0.0152
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0008 0.0012
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0008 0.0012
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0037 0.0034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0008 0.0012
Echinococcus multilocularis 0.0086 0.0491 0.0487
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0008 0.0012
Onchocerca volvulus 0.0073 0.0396 0.2315
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0037 0.0034
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0054 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0396 0.0966
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0218 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0086 0.0491 0.1207
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0024 0.005
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0086 0.0491 0.12
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0083
Schistosoma mansoni hypothetical protein 0.0086 0.0491 0.0487
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0022 0.0036 0.0209
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.0037 0.0034
Loa Loa (eye worm) IMP dehydrogenase 1 0.0588 0.4066 1
Echinococcus granulosus nAChR subunit 0.0023 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0054 0.0258 0.0627
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0022 0.0036 0.0032
Brugia malayi topoisomerase 0.0021 0.0024 0.005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 31 nM Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex ChEMBL. 2573731
IC50 (binding) = 31 nM Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex ChEMBL. 2573731
MED (functional) = 25 mg kg-1 Minimum effective dose (po) tested for its anxiolytic activity in rat using the shock-induced suppression of drinking (SSD) test. ChEMBL. 2573731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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