Detailed information for compound 1409317

Basic information

Technical information
  • TDR Targets ID: 1409317
  • Name: 2-chloro-N-(3-methylphenyl)-5-phenylsulfonylb enzamide
  • MW: 385.864 | Formula: C20H16ClNO3S
  • H donors: 1 H acceptors: 3 LogP: 4.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)c1cc(ccc1Cl)S(=O)(=O)c1ccccc1
  • InChi: 1S/C20H16ClNO3S/c1-14-6-5-7-15(12-14)22-20(23)18-13-17(10-11-19(18)21)26(24,25)16-8-3-2-4-9-16/h2-13H,1H3,(H,22,23)
  • InChiKey: ITDWXXHEWWDSLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(3-methylphenyl)-5-phenylsulfonyl-benzamide
  • 2-chloro-N-(3-methylphenyl)-5-(phenylsulfonyl)benzamide
  • MLS000537571
  • SMR000161567
  • ZINC00645318

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Sus scrofa Calpain 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis calpain family protein 1, d Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus family C2 unassigned peptidase C02 family Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K08585 calpain, invertebrate, putative Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_127139 All targets in OG5_127139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Calpain-1 catalytic subunit, putative Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Calpain-A, putative Get druggable targets OG5_127139 All targets in OG5_127139
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni calpain C (C02 family) Calpain 2   324 aa 319 aa 27.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Schistosoma japonicum Calpain-9, putative Calpain 2   324 aa 275 aa 27.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Echinococcus multilocularis calpain Calpain 2   324 aa 320 aa 31.9 %
Plasmodium vivax hypothetical protein, conserved Calpain 2   324 aa 277 aa 19.9 %
Schistosoma mansoni calpain (C02 family) Calpain 2   324 aa 318 aa 24.2 %
Echinococcus granulosus calpain A Calpain 2   324 aa 297 aa 27.6 %
Echinococcus granulosus calpain Calpain 2   324 aa 322 aa 31.7 %
Echinococcus multilocularis hypothetical protein Calpain 2   324 aa 297 aa 27.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.023 0.0653
Entamoeba histolytica prolyl oligopeptidase family protein 0.0165 0.0887 0.3797
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Entamoeba histolytica calpain family cysteine protease, putative 0.0111 0.0485 0.1875
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.023 0.0241
Loa Loa (eye worm) calpain D 0.0111 0.0485 0.0509
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0565 0.0593
Echinococcus granulosus proteasome prosome macropain 0.0082 0.0273 0.0273
Plasmodium vivax histone deacetylase 1, putative 0.0086 0.03 0.0835
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0257 0.1564 0.1559
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1022 0.1022
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0165 0.0887 0.0887
Trypanosoma cruzi cysteine peptidase, putative 0.0437 0.2896 0.2971
Trypanosoma brucei prolyl oligopeptidase, putative 0.0547 0.3713 0.3837
Echinococcus multilocularis expressed protein 0.0764 0.5317 0.5317
Trypanosoma cruzi kinesin, putative 0.0281 0.1743 0.1749
Schistosoma mansoni histone deacetylase 4 5 0.0096 0.0378 0.0378
Trichomonas vaginalis calpain, putative 0.0111 0.0485 0.1281
Loa Loa (eye worm) hypothetical protein 0.034 0.2184 0.2292
Mycobacterium ulcerans proteasome PrcB 0.0082 0.0273 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Toxoplasma gondii cathepsin B 0.0241 0.145 0.1438
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Trypanosoma brucei antigen, putative 0.0392 0.2563 0.2618
Leishmania major cathepsin L-like protease 0.034 0.2184 0.2216
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Brugia malayi Cathepsin L-like cysteine proteinase 0.0233 0.1392 0.1461
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0058 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Schistosoma mansoni microtubule-associated protein tau 0.1398 1 1
Brugia malayi Pre-SET motif family protein 0.0414 0.2729 0.2865
Schistosoma mansoni cathepsin B (C01 family) 0.0076 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Schistosoma mansoni calpain C (C02 family) 0.0392 0.2563 0.2563
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0064 0.0137 0.0047
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0046 0.0005 0.0005
Onchocerca volvulus 0.0472 0.3154 0.3308
Trypanosoma brucei cysteine peptidase, putative 0.0111 0.0485 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0076 0.023 0.0446
Brugia malayi EF hand family protein 0.0058 0.0093 0.0098
Giardia lamblia Cathepsin B precursor 0.0241 0.145 0.5506
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0408 0.2686 0.2686
Echinococcus multilocularis calpain 5 0.0392 0.2563 0.2563
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0165 0.0887 0.0841
Entamoeba histolytica calpain large subunit domain III containing protein 0.0281 0.1743 0.7894
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Brugia malayi Thioredoxin family protein 0.0391 0.2553 0.2681
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0036 0.0036
Loa Loa (eye worm) prolyl oligopeptidase 0.0493 0.3313 0.3478
Loa Loa (eye worm) prolyl oligopeptidase 0.0165 0.0887 0.0931
Trypanosoma cruzi oligopeptidase b 0.0547 0.3713 0.3837
Echinococcus granulosus enteropeptidase 0.0046 0.0005 0.0005
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0547 0.3713 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Echinococcus granulosus histone deacetylase 0.0096 0.0378 0.0378
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0105 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0165 0.0887 0.3214
Loa Loa (eye worm) hypothetical protein 0.0233 0.1392 0.1461
Loa Loa (eye worm) cathepsin B 0.0241 0.145 0.1522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0105 0.0105
Schistosoma mansoni cathepsin s 0.0107 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0774 0.5389 0.5658
Brugia malayi hypothetical protein 0.0092 0.0343 0.036
Giardia lamblia Hypothetical protein 0.0076 0.023 0.0536
Echinococcus multilocularis proteasome (prosome, macropain) 0.0082 0.0273 0.0273
Trypanosoma cruzi cysteine peptidase, putative 0.034 0.2184 0.2216
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Loa Loa (eye worm) hypothetical protein 0.0082 0.0274 0.0288
Loa Loa (eye worm) programmed cell death protein 6 0.0059 0.0098 0.0103
Giardia lamblia Cathepsin B precursor 0.0076 0.023 0.0536
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1777 0.1777
Onchocerca volvulus 0.034 0.2184 0.2288
Echinococcus granulosus cathepsin L cysteine protease 0.0183 0.1022 0.1022
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0076 0.023 0.0446
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0082 0.0273 0.0858
Plasmodium falciparum serine repeat antigen 6 0.0076 0.023 0.0653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Loa Loa (eye worm) hypothetical protein 0.0107 0.0458 0.0481
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0089 0.0089
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0105 0.0105
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0059 0.0098 0.0098
Loa Loa (eye worm) trypsin family protein 0.0046 0.0005 0.0005
Trypanosoma cruzi cysteine protease, putative 0.0183 0.1022 0.0984
Leishmania major kinesin, putative 0.0281 0.1743 0.1749
Loa Loa (eye worm) calpain family protein 1 0.0774 0.5389 0.5658
Echinococcus multilocularis histone deacetylase 6 0.0102 0.0422 0.0422
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0165 0.0887 0.2594
Echinococcus granulosus calpain 0.0392 0.2563 0.2563
Echinococcus granulosus calmodulin 0.0058 0.0093 0.0093
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Echinococcus granulosus calpain A 0.0392 0.2563 0.2563
Echinococcus granulosus Dipeptidyl peptidase 9 0.0257 0.1564 0.1564
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Plasmodium falciparum serine repeat antigen 3 0.0076 0.023 0.0653
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0408 0.2686 0.2686
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1022 0.4442
Mycobacterium leprae Conserved hypothetical protein 0.0391 0.2553 0.663
Echinococcus granulosus calpain A 0.1114 0.7899 0.7899
Echinococcus multilocularis histone deacetylase 3 0.0086 0.03 0.03
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Echinococcus granulosus prolyl endopeptidase 0.1333 0.9526 0.9526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Toxoplasma gondii hypothetical protein 0.0111 0.0485 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.1022 0.0984
Loa Loa (eye worm) hypothetical protein 0.061 0.4175 0.4383
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.023 0.0241
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.034 0.2184 0.2292
Brugia malayi cathepsin L precursor 0.0076 0.023 0.0241
Schistosoma mansoni cathepsin F (C01 family) 0.034 0.2184 0.2184
Echinococcus granulosus EF hand domain containing family member A2 0.0059 0.0098 0.0098
Leishmania major cathepsin L-like protease 0.034 0.2184 0.2216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Brugia malayi hypothetical protein 0.0286 0.1777 0.1866
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0559 0.1496
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1777 0.1777
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0559 0.1496
Onchocerca volvulus Cathepsin F homolog 0.034 0.2184 0.2288
Brugia malayi calpain family protein 1 0.1055 0.7467 0.7838
Echinococcus granulosus programmed cell death protein 0.0058 0.0093 0.0093
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0064 0.0137 0.0137
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0559 0.0559
Schistosoma mansoni mitochondrial solute carrier 0.0058 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0559 0.0357
Trypanosoma brucei kinesin, putative 0.0281 0.1743 0.1749
Trypanosoma brucei calpain, putative 0.0111 0.0485 0.0415
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Schistosoma mansoni calpain-2 (C02 family) 0.0111 0.0485 0.0485
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Brugia malayi Trypsin family protein 0.0046 0.0005 0.0005
Giardia lamblia Cathepsin B precursor 0.0076 0.023 0.0536
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0165 0.0887 0.0887
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1113 0.7894 0.7894
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1022 0.1073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0391 0.2553 0.2839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Plasmodium vivax proteasome subunit beta type-5, putative 0.0082 0.0273 0.0726
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0076 0.023 0.023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Schistosoma mansoni calpain-7 (C02 family) 0.0392 0.2563 0.2563
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0111 0.0485 0.0415
Echinococcus granulosus cysteine protease 0.0183 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Echinococcus multilocularis cathepsin L 0.0183 0.1022 0.1022
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Echinococcus multilocularis calpain 0.0392 0.2563 0.2563
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Echinococcus granulosus tumor protein p63 0.0342 0.2195 0.2195
Trypanosoma brucei Calpain-like protein 2 0.0111 0.0485 0.0415
Schistosoma mansoni calpain (C02 family) 0.0392 0.2563 0.2563
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0107 0.0458 0.0481
Toxoplasma gondii cathepsin CPL 0.034 0.2184 0.2216
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0076 0.023 0.0653
Echinococcus multilocularis cysteine protease 0.034 0.2184 0.2184
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0111 0.0485 0.0415
Toxoplasma gondii cathepsin CPC1 0.0076 0.023 0.0145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Echinococcus granulosus cathepsin l1 0.034 0.2184 0.2184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0076
Echinococcus granulosus calumenin 0.0059 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.023 0.0653
Schistosoma mansoni neuronal calcium sensor 0.0058 0.0093 0.0093
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0064 0.0137 0.0137
Entamoeba histolytica cysteine proteinase, putative 0.0233 0.1392 0.6211
Leishmania major histone deacetylase, putative 0.0096 0.0378 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0233 0.1392 0.4244
Brugia malayi calcium-binding protein 0.0058 0.0093 0.0098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.061 0.4175 0.4175
Brugia malayi Cathepsin L-like precursor 0.0233 0.1392 0.1461
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0458 0.0386
Schistosoma mansoni rab 0.0058 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0076 0.023 0.0446
Trypanosoma brucei histone deacetylase 1 0.0086 0.03 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0098 0.002
Onchocerca volvulus 0.034 0.2184 0.2288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Schistosoma mansoni ef hand domain family member A2 0.0058 0.0093 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Giardia lamblia Cathepsin L-like protease 0.0076 0.023 0.0536
Mycobacterium ulcerans hypothetical protein 0.0391 0.2553 0.6874
Echinococcus multilocularis cathepsin l cysteine peptidase 0.034 0.2184 0.2184
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0046 0.0005 0.0005
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.023 0.0536
Echinococcus multilocularis EF hand domain containing family member A2 0.0058 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.1022 0.0984
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.023 0.0145
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0559 0.0494
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Leishmania major histone deacetylase, putative 0.0086 0.03 0.0219
Mycobacterium tuberculosis Conserved protein 0.0391 0.2553 0.2839
Echinococcus granulosus cathepsin b 0.061 0.4175 0.4175
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.023 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Trichomonas vaginalis calpain, putative 0.0111 0.0485 0.1281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Giardia lamblia Cathepsin B precursor 0.0076 0.023 0.0536
Toxoplasma gondii cathepsin CPC2 0.0076 0.023 0.0145
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Trypanosoma cruzi prolyl endopeptidase 0.1333 0.9526 1
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0547 0.3713 0.3837
Loa Loa (eye worm) hypothetical protein 0.0286 0.1777 0.1866
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Echinococcus multilocularis calbindin 32 0.0059 0.0098 0.0098
Onchocerca volvulus 0.0058 0.0096 0.0096
Trichomonas vaginalis hypothetical protein 0.0111 0.0485 0.1281
Trypanosoma brucei prolyl endopeptidase 0.1333 0.9526 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0105 0.0105
Plasmodium falciparum histone deacetylase, putative 0.0096 0.0378 0.136
Loa Loa (eye worm) hypothetical protein 0.0306 0.1925 0.2021
Brugia malayi Papain family cysteine protease containing protein 0.034 0.2184 0.2292
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2563 0.2618
Trichomonas vaginalis calmodulin, putative 0.0059 0.0098 0.0017
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0064 0.0137 0.021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0241 0.145 0.145
Brugia malayi fibroinase precursor 0.0076 0.023 0.0241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.061 0.4175 0.4175
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Echinococcus granulosus histone deacetylase 6 0.0102 0.0422 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Onchocerca volvulus 0.005 0.0036 0.0033
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0183 0.1022 0.0984
Trypanosoma cruzi cruzipain precursor, putative 0.0437 0.2896 0.2971
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Schistosoma mansoni reticulocalbin 0.0059 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0107 0.0458 0.0481
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1022 0.1073
Plasmodium falciparum serine repeat antigen 2 0.0076 0.023 0.0653
Loa Loa (eye worm) hypothetical protein 0.0111 0.0485 0.0509
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0076 0.023 0.0241
Brugia malayi Cathepsin L-like precursor 0.0107 0.0458 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Loa Loa (eye worm) papain family cysteine protease containing protein 0.034 0.2184 0.2292
Schistosoma mansoni hypothetical protein 0.0046 0.0005 0.0005
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2563 0.2618
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2563 0.2618
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1333 0.9526 0.9526
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.1022 0.3036
Brugia malayi programmed cell death protein 6 0.0058 0.0093 0.0098
Schistosoma mansoni hypothetical protein 0.0082 0.0274 0.0274
Echinococcus multilocularis cathepsin l cysteine peptidase 0.034 0.2184 0.2184
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Trypanosoma brucei calpain, putative 0.0111 0.0485 0.0415
Plasmodium vivax vivapain-1 0.0183 0.1022 0.376
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0257 0.1564 0.1559
Schistosoma mansoni hypothetical protein 0.0046 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2184 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Loa Loa (eye worm) hypothetical protein 0.0092 0.0343 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.1022 0.0984
Leishmania major cathepsin L-like protease 0.034 0.2184 0.2216
Plasmodium vivax unspecified product 0.0107 0.0458 0.1476
Brugia malayi cathepsin B-like cysteine proteinase 0.061 0.4175 0.4383
Loa Loa (eye worm) hypothetical protein 0.0233 0.1392 0.1461
Giardia lamblia Proteasome subunit beta type 1 0.0064 0.0137 0.0159
Loa Loa (eye worm) proteasome subunit beta type 1 0.0064 0.0137 0.0144
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0046 0.0005 0.0005
Schistosoma mansoni Mername-AA248 (C02 family) 0.0392 0.2563 0.2563
Schistosoma mansoni histone deacetylase hda2 0.0102 0.0422 0.0422
Brugia malayi Trypsin family protein 0.0046 0.0005 0.0005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1022 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0241 0.145 0.4435
Giardia lamblia Cathepsin L-like protease 0.0076 0.023 0.0536
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0137 0.0144
Mycobacterium tuberculosis Conserved hypothetical protein 0.0391 0.2553 0.2839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0111 0.0485 0.0415
Brugia malayi prolyl oligopeptidase family protein 0.0493 0.3313 0.3478
Schistosoma mansoni neuronal calcium sensor 0.0058 0.0093 0.0093
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1113 0.7894 0.7894
Brugia malayi proteasome subunit beta type 1 0.0064 0.0137 0.0144
Echinococcus granulosus EF hand domain containing family member A2 0.0058 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0111 0.0485 0.0485
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0493 0.3313 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Entamoeba histolytica histone deacetylase, putative 0.0086 0.03 0.0986
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0076 0.023 0.023
Onchocerca volvulus 0.0076 0.023 0.0237
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0086 0.03 0.0674
Plasmodium falciparum proteasome subunit beta type-5 0.0082 0.0273 0.0858
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Mycobacterium tuberculosis Hypothetical protein 0.0391 0.2553 0.2839
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0241
Onchocerca volvulus 0.0576 0.3924 0.4116
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Echinococcus granulosus cathepsin l1 0.0233 0.1392 0.1392
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0082 0.0273 0.071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Brugia malayi Pre-SET motif family protein 0.0059 0.0105 0.011
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0165 0.0887 0.3797
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0058 0.0093 0.0093
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0183 0.1022 0.1022
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0086 0.03 0.0674
Trypanosoma cruzi histone deacetylase 1, putative 0.0086 0.03 0.0219
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0408 0.2686 0.2686
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Echinococcus granulosus EF HAND 1 calcium binding site 0.0058 0.0093 0.0093
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Echinococcus granulosus calcium uptake protein 1 0.0059 0.0098 0.0098
Plasmodium vivax vivapain-2 0.034 0.2184 0.8465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.023 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.1317 0.1317
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.023 0.0553
Schistosoma mansoni neuronal calcium sensor 0.0058 0.0093 0.0093
Loa Loa (eye worm) histone deacetylase 3 0.0086 0.03 0.0314
Loa Loa (eye worm) hypothetical protein 0.0058 0.0093 0.0098
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0064 0.0137 0.0047
Trichomonas vaginalis peptide N-glycanase, putative 0.0391 0.2553 0.8043
Plasmodium falciparum calpain 0.0111 0.0485 0.1875
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0046 0.0005 0.0005
Echinococcus multilocularis histone deacetylase 6 0.0096 0.0378 0.0378
Giardia lamblia Hypothetical protein 0.0391 0.2553 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0257 0.1564 0.1559
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0257 0.1564 0.1564
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2563 0.2618
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.023 0.0536
Brugia malayi EF hand family protein 0.0059 0.0098 0.0103
Plasmodium vivax unspecified product 0.0183 0.1022 0.376
Echinococcus granulosus acylamino acid releasing enzyme 0.0165 0.0887 0.0887
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0076 0.023 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Trypanosoma brucei Calpain-like protein 1.2 0.0111 0.0485 0.0415
Mycobacterium ulcerans transglutaminase family protein 0.0391 0.2553 0.6874
Echinococcus multilocularis cathepsin b 0.061 0.4175 0.4175
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0378 0.0301
Schistosoma mansoni survival motor neuron protein 0.0058 0.0096 0.0096
Echinococcus granulosus histone deacetylase 7 0.0096 0.0378 0.0378
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0082 0.0273 0.0586
Toxoplasma gondii calmodulin CAM1 0.0059 0.0098 0.0005
Echinococcus granulosus histone deacetylase 3 0.0086 0.03 0.03
Entamoeba histolytica prolyl oligopeptidase family protein 0.0165 0.0887 0.3797
Onchocerca volvulus 0.0059 0.0105 0.0106
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0559 0.0494
Toxoplasma gondii hypothetical protein 0.0165 0.0887 0.0841
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Trypanosoma brucei histone deacetylase 3 0.0096 0.0378 0.0301
Toxoplasma gondii prolyl endopeptidase 0.1333 0.9526 1
Brugia malayi calpain family protein 1 0.1055 0.7467 0.7838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.023 0.0446
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Schistosoma mansoni memapsin-2 (A01 family) 0.0426 0.2817 0.2817
Echinococcus multilocularis histone deacetylase 7 0.0096 0.0378 0.0378
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1333 0.9526 0.9526
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0165 0.0887 0.2594
Onchocerca volvulus 0.0663 0.457 0.4795
Loa Loa (eye worm) fibroinase 0.034 0.2184 0.2292
Echinococcus multilocularis cathepsin L 0.0076 0.023 0.023
Toxoplasma gondii preprocathepsin c precursor, putative 0.0076 0.023 0.0145
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0105 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.023 0.023
Plasmodium falciparum serine repeat antigen 5 0.0076 0.023 0.0653
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Echinococcus granulosus cathepsin L cysteine proteinase 0.034 0.2184 0.2184
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.023 0.0241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0105 0.0105
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.1022 0.0984
Brugia malayi Histone deacetylase 1 0.0086 0.03 0.0314
Schistosoma mansoni cathepsin C 0.0076 0.023 0.023
Leishmania major cathepsin L-like protease 0.0437 0.2896 0.2971
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.023 0.0446
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0274 0.0288
Echinococcus multilocularis EF hand domain containing family member A2 0.0059 0.0098 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0559 0.1496
Brugia malayi calpain 5 0.0111 0.0485 0.0509
Loa Loa (eye worm) hypothetical protein 0.0153 0.0797 0.0837
Brugia malayi Proteasome A-type and B-type family protein 0.0082 0.0273 0.0286
Echinococcus multilocularis calmodulin 0.0058 0.0093 0.0093
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0111 0.0485 0.0415
Plasmodium falciparum serine repeat antigen 7 0.0076 0.023 0.0653
Mycobacterium leprae Conserved hypothetical protein 0.0391 0.2553 0.663
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Giardia lamblia Alanyl dipeptidyl peptidase 0.0165 0.0887 0.3212
Giardia lamblia Cysteine protease 0.0076 0.023 0.0536
Loa Loa (eye worm) hypothetical protein 0.0107 0.0458 0.0481
Leishmania major histone deacetylase, putative 0.0096 0.0378 0.0301
Loa Loa (eye worm) hypothetical protein 0.1333 0.9526 1
Giardia lamblia Cathepsin B precursor 0.0241 0.145 0.5506
Loa Loa (eye worm) hypothetical protein 0.0059 0.0105 0.011
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0392 0.2563 0.2618
Entamoeba histolytica cysteine protease, putative 0.034 0.2184 1
Loa Loa (eye worm) histone deacetylase 7A 0.0096 0.0378 0.0396
Echinococcus multilocularis neurocalcin 0.0058 0.0093 0.0093
Trypanosoma brucei Calpain-like protein CALP1.3 0.0111 0.0485 0.0415
Schistosoma mansoni cathepsin F (C01 family) 0.034 0.2184 0.2184
Schistosoma mansoni hypothetical protein 0.0391 0.2553 0.2553
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0076 0.023 0.0241
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1168 0.8305 1
Brugia malayi Cathepsin L-like precursor 0.0233 0.1392 0.1461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Plasmodium vivax unspecified product 0.0076 0.023 0.0553
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Onchocerca volvulus Prolyl endopeptidase homolog 0.1333 0.9526 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0076 0.023 0.0241
Schistosoma mansoni neuronal calcium sensor 0.0058 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Echinococcus multilocularis cathepsin L cysteine protease 0.034 0.2184 0.2184
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2563 0.2618
Plasmodium falciparum serine repeat antigen 4 0.0076 0.023 0.0653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Echinococcus granulosus neurocalcin 0.0058 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0887 0.2594
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Trichomonas vaginalis calcineurin B subunit, putative 0.0059 0.0098 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.023 0.0446
Echinococcus multilocularis calmodulin 0.0058 0.0093 0.0093
Echinococcus multilocularis histone deacetylase 0.0096 0.0378 0.0378
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0082 0.0273 0.0273
Trypanosoma cruzi conserved protein 0.0111 0.0485 0.0415
Echinococcus multilocularis histone deacetylase 1 0.0086 0.03 0.03
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.2729 0.2865
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0257 0.1564 0.1559
Leishmania major oligopeptidase b 0.0547 0.3713 0.3837
Echinococcus granulosus expressed protein 0.0764 0.5317 0.5317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.023 0.023
Loa Loa (eye worm) calpain family protein 1 0.1055 0.7467 0.7838
Echinococcus granulosus calbindin 32 0.0059 0.0098 0.0098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.1317 0.1317
Echinococcus multilocularis centrin 2 0.0058 0.0093 0.0093
Leishmania major histone deacetylase, putative 0.0086 0.03 0.0219
Echinococcus granulosus cathepsin l cysteine peptidase 0.034 0.2184 0.2184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Giardia lamblia Cysteine protease 0.0076 0.023 0.0536
Brugia malayi Trypsin family protein 0.0046 0.0005 0.0005
Brugia malayi hypothetical protein 0.0153 0.0797 0.0837
Plasmodium vivax SET domain protein, putative 0.0059 0.0105 0.0048
Trichomonas vaginalis calpain, putative 0.0111 0.0485 0.1281
Trypanosoma cruzi hypothetical protein, conserved 0.0165 0.0887 0.0841
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0493 0.3313 0.3475
Brugia malayi histone deacetylase 3 (HD3) 0.0086 0.03 0.0314
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0547 0.3713 1
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0378 0.0301
Schistosoma mansoni calpain-7 (C02 family) 0.0392 0.2563 0.2563
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Trypanosoma brucei calmodulin, putative 0.0059 0.0098 0.0005
Onchocerca volvulus Cathepsin L homolog 0.034 0.2184 0.2288
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1113 0.7894 0.7894
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.023 0.0241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.023 0.023
Onchocerca volvulus 0.0059 0.0098 0.0098
Brugia malayi Trypsin-like protease protein 5 0.0046 0.0005 0.0005
Loa Loa (eye worm) EF hand family protein 0.0058 0.0093 0.0098
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0082 0.0273 0.019
Giardia lamblia Encystation-specific protease 0.0076 0.023 0.0536
Brugia malayi prolyl oligopeptidase family protein 0.1333 0.9526 1
Echinococcus granulosus centrin 2 0.0058 0.0093 0.0093
Echinococcus granulosus histone deacetylase 6 0.0096 0.0378 0.0378
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.023 0.0446
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0076 0.023 0.0553
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.023 0.0446
Brugia malayi calpain 7 0.0392 0.2563 0.269
Echinococcus multilocularis neuronal calcium sensor 0.0058 0.0093 0.0093
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.023 0.023
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.061 0.4175 0.4175
Trichomonas vaginalis set domain proteins, putative 0.0471 0.3152 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.023 0.0446
Plasmodium falciparum cysteine proteinase falcipain 2a 0.034 0.2184 1
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1055 0.7467 0.7467
Giardia lamblia Cysteine protease 0.0076 0.023 0.0536
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1022 0.4442
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Echinococcus multilocularis prolyl endopeptidase 0.1333 0.9526 0.9526
Trypanosoma cruzi cysteine peptidase, putative 0.0437 0.2896 0.2971
Leishmania major hypothetical protein, conserved 0.0059 0.0098 0.0005
Mycobacterium tuberculosis Probable peptidase 0.0547 0.3713 0.4283
Schistosoma mansoni calmodulin related calcium binding protein 0.0058 0.0093 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0105 0.0105
Schistosoma mansoni cathepsin S (C01 family) 0.0076 0.023 0.023
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0165 0.0887 0.3797
Brugia malayi calpain 5 0.0281 0.1743 0.183
Loa Loa (eye worm) histone deacetylase 0.0096 0.0378 0.0396
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0493 0.3313 0.3313
Plasmodium falciparum cysteine proteinase falcipain 3 0.034 0.2184 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.023 0.0553
Loa Loa (eye worm) hypothetical protein 0.0165 0.0887 0.0931
Trypanosoma cruzi histone deacetylase 1, putative 0.0086 0.03 0.0219
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0064 0.0137 0.021
Leishmania major cathepsin L-like protease 0.0437 0.2896 0.2971
Trypanosoma brucei proteasome beta 6 subunit 0.0064 0.0137 0.0047
Echinococcus multilocularis programmed cell death protein 0.0058 0.0093 0.0093
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Schistosoma mansoni histone deacetylase 4 5 0.0096 0.0378 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Plasmodium falciparum histone deacetylase 1 0.0086 0.03 0.0986
Giardia lamblia Alanyl dipeptidyl peptidase 0.0165 0.0887 0.3212
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Loa Loa (eye worm) calpain 5 0.0281 0.1743 0.183
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0064 0.0137 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.1925 0.2021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0076 0.023 0.0446
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0493 0.3313 0.3313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Plasmodium vivax histone deacetylase, putative 0.0096 0.0378 0.1151
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0241 0.145 0.1438
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0257 0.1564 0.1564
Echinococcus multilocularis Transglutaminase 0.0391 0.2553 0.2553
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0165 0.0887 0.0841
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Loa Loa (eye worm) hypothetical protein 0.1055 0.7467 0.7838
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.0137 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Entamoeba histolytica hypothetical protein, conserved 0.0165 0.0887 0.3797
Echinococcus multilocularis calpain family protein 1, d 0.0774 0.5389 0.5389
Loa Loa (eye worm) hypothetical protein 0.0233 0.1392 0.1461
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0111 0.0485 0.0415
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1113 0.7894 0.7894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Onchocerca volvulus 0.0058 0.0093 0.0093
Echinococcus multilocularis calcium uptake protein 1 0.0059 0.0098 0.0098
Echinococcus multilocularis glycoprotein Antigen 5 0.0046 0.0005 0.0005
Schistosoma mansoni histone deacetylase 0.0086 0.03 0.03
Echinococcus granulosus histone deacetylase 6 0.0096 0.0378 0.0378
Trypanosoma brucei histone deacetylase 4 0.0096 0.0378 0.0301
Onchocerca volvulus 0.0058 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Brugia malayi Calmodulin-like protein 0.0058 0.0093 0.0098
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0076 0.023 0.0553
Schistosoma mansoni calmodulin 0.0058 0.0093 0.0093
Brugia malayi Histone deacetylase family protein 0.0096 0.0378 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.1022 0.3036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0556 0.0584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.034 0.2184 0.6833
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0076 0.023 0.0653
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1333 0.9526 1
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Plasmodium falciparum cysteine proteinase falcipain 1 0.0183 0.1022 0.4442
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2563 0.2618
Giardia lamblia Histone deacetylase 0.0086 0.03 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0165 0.0887 0.0841
Echinococcus multilocularis calumenin 0.0059 0.0098 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0559 0.0559
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0076 0.023 0.0553
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0273 0.019
Echinococcus multilocularis histone deacetylase 6 0.0096 0.0378 0.0378
Echinococcus granulosus calpain 5 0.0392 0.2563 0.2563
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0046 0.0005 0.0005
Brugia malayi histone deacetylase 1 (HD1) 0.0086 0.03 0.0314
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.061 0.4175 0.4175
Schistosoma mansoni hypothetical protein 0.0058 0.0093 0.0093
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0086 0.03 0.0674
Schistosoma mansoni hypothetical protein 0.0058 0.0096 0.0096
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.0137 0.0047
Brugia malayi prolyl oligopeptidase family protein 0.0165 0.0887 0.0931
Echinococcus multilocularis enteropeptidase 0.0046 0.0005 0.0005
Echinococcus granulosus transmembrane protease serine 3 0.0046 0.0005 0.0005
Schistosoma mansoni calmodulin 0.0058 0.0093 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0559 0.0559
Plasmodium vivax proteasome subunit beta type-1, putative 0.0064 0.0137 0.0178
Brugia malayi cathepsin F-like cysteine proteinase 0.0107 0.0458 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Onchocerca volvulus Cathepsin L homolog 0.034 0.2184 0.2288
Plasmodium falciparum histone deacetylase 2 0.0096 0.0378 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.023 0.0446
Brugia malayi Cytochrome P450 family protein 0.0054 0.0062 0.0065
Brugia malayi Trypsin family protein 0.0046 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0378 0.0301
Schistosoma mansoni histone deacetylase 0.0086 0.03 0.03
Giardia lamblia Cathepsin B precursor 0.0076 0.023 0.0536
Plasmodium falciparum cysteine proteinase falcipain 2b 0.034 0.2184 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Loa Loa (eye worm) calpain 0.0392 0.2563 0.269
Entamoeba histolytica cysteine proteinase 2 0.0183 0.1022 0.4442
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2184 1
Onchocerca volvulus 0.034 0.2184 0.2288
Loa Loa (eye worm) hypothetical protein 0.0058 0.0093 0.0098
Onchocerca volvulus 0.034 0.2184 0.2288
Echinococcus granulosus cathepsin b 0.061 0.4175 0.4175
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Echinococcus multilocularis Mastin 0.0046 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.033 0.2104 0.2131
Giardia lamblia Cathepsin L precursor 0.0076 0.023 0.0536
Leishmania major hypothetical protein, unknown function 0.0111 0.0485 0.0415
Leishmania major proteasome beta 5 subunit, putative 0.0082 0.0273 0.019
Onchocerca volvulus 0.0153 0.0797 0.0832
Plasmodium vivax histone deacetylase 2, putative 0.0096 0.0378 0.1151
Brugia malayi cathepsin L-like precursor 0.0233 0.1392 0.1461
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0556 0.0584
Echinococcus granulosus cathepsin L 0.0076 0.023 0.023
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.023 0.0553
Trypanosoma cruzi cysteine peptidase, putative 0.0437 0.2896 0.2971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Brugia malayi Histone deacetylase family protein 0.0096 0.0378 0.0396
Brugia malayi calpain D 0.0111 0.0485 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.023 0.0446
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.023 0.0553
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0257 0.1564 0.1559
Leishmania major cysteine peptidase A (CPA) 0.034 0.2184 0.2216
Brugia malayi prolyl oligopeptidase family protein 0.0165 0.0887 0.0931
Echinococcus granulosus cathepsin L 0.0183 0.1022 0.1022
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Trypanosoma cruzi oligopeptidase b 0.0547 0.3713 0.3837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.0458 0.0481
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Onchocerca volvulus 0.034 0.2184 0.2288
Toxoplasma gondii histone deacetylase HDAC1 0.0096 0.0378 0.0301
Trypanosoma brucei Calpain-like protein 1.1 0.0111 0.0485 0.0415
Schistosoma mansoni cathepsin F (C01 family) 0.0233 0.1392 0.1392
Echinococcus multilocularis microtubule associated protein 2 0.1398 1 1
Entamoeba histolytica hypothetical protein 0.0076 0.023 0.0653
Echinococcus granulosus Mastin 0.0046 0.0005 0.0005
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Schistosoma mansoni centrin-related 0.0058 0.0093 0.0093
Onchocerca volvulus Cathepsin L homolog 0.0076 0.023 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0233 0.1392 0.4244
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0111 0.0485 0.0415
Trypanosoma brucei histone deacetylase, putative 0.0096 0.0378 0.0301
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0082 0.0273 0.0286
Loa Loa (eye worm) histone deacetylase 1 0.0086 0.03 0.0314
Plasmodium falciparum serine repeat antigen 8 0.0076 0.023 0.0653
Giardia lamblia Cysteine protease 0.0076 0.023 0.0536
Giardia lamblia Transglutaminase/protease, putative 0.0391 0.2553 1
Plasmodium vivax vivapain-3 0.0183 0.1022 0.376
Brugia malayi MH2 domain containing protein 0.0122 0.0565 0.0593
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Schistosoma mansoni centrin 0.0058 0.0093 0.0093
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Echinococcus multilocularis hypothetical protein 0.0392 0.2563 0.2563
Plasmodium falciparum serine repeat antigen 1 0.0076 0.023 0.0653
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0058 0.0093 0.0093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.023 0.023
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0076 0.023 0.0536
Entamoeba histolytica cysteine protease, putative 0.0076 0.023 0.0653
Entamoeba histolytica cysteine proteinase 1, putative 0.0183 0.1022 0.4442
Brugia malayi prolyl oligopeptidase family protein 0.0257 0.1564 0.1642
Trichomonas vaginalis histone deacetylase, putative 0.0086 0.03 0.0674
Echinococcus granulosus histone deacetylase 1 0.0086 0.03 0.03
Brugia malayi Cathepsin L-like precursor 0.034 0.2184 0.2292
Echinococcus granulosus glycoprotein Antigen 5 0.0046 0.0005 0.0005
Leishmania major calpain protease-like protein 0.0111 0.0485 0.0415
Onchocerca volvulus 0.034 0.2184 0.2288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.023 0.0446
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0096 0.0101
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0257 0.1564 0.1559
Echinococcus multilocularis cathepsin L cysteine protease 0.034 0.2184 0.2184
Brugia malayi cathepsin L-like cysteine proteinase 0.0076 0.023 0.0241
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0076 0.023 0.0553
Toxoplasma gondii proteasome subunit beta type, putative 0.0082 0.0273 0.019
Echinococcus multilocularis cysteine protease 0.034 0.2184 0.2184
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0076 0.023 0.0553
Leishmania major cathepsin L-like protease 0.034 0.2184 0.2216
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.034 0.2184 0.6833
Echinococcus multilocularis transmembrane protease serine 3 0.0046 0.0005 0.0005
Echinococcus multilocularis tumor protein p63 0.0342 0.2195 0.2195
Entamoeba histolytica grainin, putative 0.0059 0.0098 0.0024
Echinococcus multilocularis acylamino acid releasing enzyme 0.0165 0.0887 0.0887
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.023 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0559 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0485 0.1281
Mycobacterium tuberculosis Long conserved protein 0.0391 0.2553 0.2839
Echinococcus granulosus calpain 7 C02 family 0.0392 0.2563 0.2563
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1022 0.4442
Loa Loa (eye worm) hypothetical protein 0.0944 0.6647 0.6978
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.023 0.023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0005 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0062 0.0065
Giardia lamblia Cathepsin B precursor 0.0076 0.023 0.0536
Leishmania major calpain family cysteine protease-like protein 0.0111 0.0485 0.0415
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0241 0.145 0.1438
Loa Loa (eye worm) ctsf protein 0.034 0.2184 0.2292
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0111 0.0485 0.1281
Echinococcus multilocularis calpain 7 (C02 family) 0.0392 0.2563 0.2563
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0547 0.3713 0.4283
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0059 0.0098 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.023 0.0241
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Loa Loa (eye worm) hypothetical protein 0.0061 0.0117 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2184 0.6833
Plasmodium falciparum peptidase, putative 0.0165 0.0887 0.3797
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0485 0.0415
Toxoplasma gondii histone deacetylase HDAC3 0.0086 0.03 0.0219
Trypanosoma cruzi cysteine proteinase, putative 0.0183 0.1022 0.0984
Echinococcus granulosus Transglutaminase 0.0391 0.2553 0.2553
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0076 0.023 0.0553
Loa Loa (eye worm) cysteine protease 0.034 0.2184 0.2292
Brugia malayi hypothetical protein 0.0046 0.0005 0.0005
Onchocerca volvulus 0.034 0.2184 0.2288
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0098 0.0024
Echinococcus multilocularis calpain A 0.1114 0.7899 0.7899
Trypanosoma cruzi major cysteine proteinase, putative 0.0173 0.0942 0.09
Toxoplasma gondii calcium-dependent protein kinase 0.0059 0.0098 0.0005
Giardia lamblia Cathepsin B precursor 0.0241 0.145 0.5506
Schistosoma mansoni cercarial elastase (S01 family) 0.0046 0.0005 0.0005
Echinococcus multilocularis cathepsin b 0.061 0.4175 0.4175
Loa Loa (eye worm) hypothetical protein 0.0165 0.0887 0.0931
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0038
Entamoeba histolytica protein kinase, putative 0.0281 0.1743 0.7894
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.061 0.4175 0.4327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0437 0.2896 0.2971
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0565 0.0593
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0547 0.3713 0.3837
Entamoeba histolytica cysteine protease, putative 0.0183 0.1022 0.4442
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0547 0.3713 0.3837
Trypanosoma brucei hypothetical protein 0.0111 0.0485 0.0415
Mycobacterium ulcerans hypothetical protein 0.0391 0.2553 0.6874
Schistosoma mansoni reticulocalbin 0.0058 0.0093 0.0093
Toxoplasma gondii histone deacetylase HDAC2 0.0086 0.03 0.0219
Onchocerca volvulus 0.0233 0.1392 0.1457
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0273 0.019
Loa Loa (eye worm) calmodulin-like protein 0.0058 0.0093 0.0098
Entamoeba histolytica prolyl oligopeptidase family protein 0.0165 0.0887 0.3797
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0111 0.0485 0.0415
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0058 0.0093 0.0093
Mycobacterium ulcerans putative transglutaminase-like protein 0.0391 0.2553 0.6874
Loa Loa (eye worm) hypothetical protein 0.0046 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.023 0.0446
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.023 0.0536
Giardia lamblia Hypothetical protein 0.0076 0.023 0.0536
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.1022 0.4442
Trypanosoma brucei cysteine peptidase C (CPC) 0.0241 0.145 0.1438
Leishmania major hypothetical protein, conserved 0.0111 0.0485 0.0415
Plasmodium falciparum serine repeat antigen 9 0.0076 0.023 0.0653
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0485 0.0415
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0076 0.023 0.0553
Trypanosoma cruzi kinesin, putative 0.0281 0.1743 0.1749
Trypanosoma brucei oligopeptidase b 0.0547 0.3713 0.3837
Loa Loa (eye worm) hypothetical protein 0.0663 0.457 0.4797
Loa Loa (eye worm) hypothetical protein 0.0086 0.03 0.0314
Leishmania major cathepsin L-like protease 0.034 0.2184 0.2216
Leishmania major cathepsin L-like protease 0.0437 0.2896 0.2971
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.0458 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.034 0.2184 0.6833
Echinococcus granulosus neuronal calcium sensor 0.0058 0.0093 0.0093
Plasmodium vivax vivapain-2 0.034 0.2184 0.8465
Plasmodium vivax calpain, putative 0.0392 0.2563 1
Echinococcus multilocularis programmed cell death protein 0.0058 0.0093 0.0093
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0076 0.023 0.0653
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0547 0.3713 0.3837
Schistosoma mansoni hypothetical protein 0.0058 0.0093 0.0093

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 3.47 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 7.129260634 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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