Detailed information for compound 1431676

Basic information

Technical information
  • TDR Targets ID: 1431676
  • Name: N-(2-methoxyethyl)-2-[(4-phenyl-1,3-thiazol-2 -yl)sulfanyl]acetamide
  • MW: 308.419 | Formula: C14H16N2O2S2
  • H donors: 1 H acceptors: 2 LogP: 2.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)CSc1scc(n1)c1ccccc1
  • InChi: 1S/C14H16N2O2S2/c1-18-8-7-15-13(17)10-20-14-16-12(9-19-14)11-5-3-2-4-6-11/h2-6,9H,7-8,10H2,1H3,(H,15,17)
  • InChiKey: STIGYNWLNNWHTG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(2-methoxyethyl)-2-(4-phenylthiazol-2-yl)sulfanyl-acetamide
  • N-(2-methoxyethyl)-2-[(4-phenyl-2-thiazolyl)thio]acetamide
  • N-(2-methoxyethyl)-2-[(4-phenylthiazol-2-yl)thio]acetamide
  • N-(2-methoxyethyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]ethanamide
  • ZINC05860499
  • T5272809
  • SMR000152878
  • MLS000565738

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase SMG1 0.021 0.1676 0.1569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0314 0.0314
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0371 0.3177 0.3177
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.3177 0.3177
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0071 0.0397 0.0273
Loa Loa (eye worm) hypothetical protein 0.0233 0.1898 0.1898
Schistosoma mansoni hypothetical protein 0.0049 0.019 0.0043
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0071 0.0397 0.0299
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0162 0.1236 0.1123
Entamoeba histolytica hypothetical protein 0.0071 0.0397 0.0397
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0148 0.0047
Trypanosoma brucei cytochrome P450, putative 0.007 0.0388 0.0243
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0071 0.0397 0.0273
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0167 0.1278 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0397 0.0397
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.021 0.1676 0.1569
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0371 0.3177 0.3177
Leishmania major phosphatidylinositol kinase related protein, putative 0.0071 0.0397 0.0397
Entamoeba histolytica hypothetical protein 0.021 0.1676 0.1676
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0397 0.0273
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1108 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1108 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.5278 0.5229
Leishmania major fk506-binding protein 1-like protein 0.0167 0.1278 0.1278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.021 0.1676 0.1676
Leishmania major phosphatidylinositol kinase, putative 0.0071 0.0397 0.0397
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0071 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0049 0.019 0.0043
Brugia malayi Cytochrome P450 family protein 0.007 0.0388 0.0388
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0167 0.1278 1
Brugia malayi FAT domain containing protein 0.0162 0.1236 0.1236
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0397 0.0345
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0167 0.1278 0.1147
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0167 0.1278 0.1147
Echinococcus multilocularis 0.0071 0.0397 0.0273
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0167 0.1278 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.5869 0.5826
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0071 0.0397 0.0273
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0167 0.1278 0.1189
Trichomonas vaginalis immunophilin, putative 0.0167 0.1278 0.1189
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.5269 0.5221
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0071 0.0397 0.0273
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0397 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.5808 0.5765
Loa Loa (eye worm) hypothetical protein 0.0144 0.1066 0.1066
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0071 0.0397 0.0299
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0167 0.1278 0.1278
Echinococcus multilocularis Zinc finger, PHD finger 0.0071 0.0397 0.0273
Onchocerca volvulus 0.0071 0.0397 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0397 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0946 0.8499 0.8484
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0853 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.3177 0.3107
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0836 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.1108 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1309 0.1197
Onchocerca volvulus 0.0071 0.0397 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.79 0.7878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.5278 0.5229
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0167 0.1278 0.1147
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.021 0.1676 0.1551
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0167 0.1278 0.1166
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0071 0.0397 0.0253
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0167 0.1278 0.0918
Loa Loa (eye worm) hypothetical protein 0.0226 0.1827 0.1827
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0167 0.1278 0.1147
Brugia malayi Cytochrome P450 family protein 0.007 0.0388 0.0388
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0071 0.0397 0.0253
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0148 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.5808 0.5765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.2489 0.2412
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.1014 0.0922
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.021 0.1676 0.1676
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0105 0.2637
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0148 0.0148
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0071 0.0397 0.0397
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1108 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0127 0.0127
Schistosoma mansoni immunophilin 0.0144 0.1066 0.0932
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0207 0.0207
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0071 0.0397 0.0273
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0371 0.3177 0.3075
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0397 0.0299
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.046 0.3998 0.3908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0397 0.0299
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0071 0.0397 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0138 0.1014 0.0922
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1108 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.007 0.0388 0.3032
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0371 0.3177 0.3075
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0167 0.1278 0.1278
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0127 0.0127
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0397 0.0299
Leishmania major peptidylprolyl isomerase-like protein 0.0167 0.1278 0.1278
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0397 0.0397
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0397 0.0253
Entamoeba histolytica hypothetical protein 0.0071 0.0397 0.0397
Loa Loa (eye worm) inositol-1 0.0045 0.0148 0.0148
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0167 0.1278 0.1147
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0071 0.0397 0.0273
Loa Loa (eye worm) hypothetical protein 0.0037 0.0075 0.0075
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1108 1 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0071 0.0397 0.0253
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.1676 0.1591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.3177 0.3107
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.1108 1 1
Schistosoma mansoni immunophilin 0.0167 0.1278 0.1147
Loa Loa (eye worm) hypothetical protein 0.0071 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0162 0.1236 0.1236
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0397 0.0299
Loa Loa (eye worm) hypothetical protein 0.0051 0.0207 0.0207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1108 1 1
Entamoeba histolytica hypothetical protein 0.0071 0.0397 0.0397
Toxoplasma gondii FATC domain-containing protein 0.021 0.1676 0.2116
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0207 0.0081
Loa Loa (eye worm) hypothetical protein 0.005 0.02 0.02
Leishmania major hypothetical protein, conserved 0.0071 0.0397 0.0397
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0882 0.7908 0.7877
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0397 0.0299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Loa Loa (eye worm) hypothetical protein 0.0138 0.1014 0.1014
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0371 0.3177 0.3075
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.021 0.1676 0.1551
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0138 0.1014 0.0879
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0299
Loa Loa (eye worm) phosphatidylinositol 3 0.1108 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.5269 0.5221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0397 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.5869 0.5826
Trypanosoma cruzi target of rapamycin kinase 3 0.0882 0.7908 0.7877
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0388 0.0388
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0397 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.1676 0.1591
Trichomonas vaginalis fk506-binding protein, putative 0.0167 0.1278 0.1189
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0397 0.0397
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0144 0.1066 0.0951
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1108 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.1236 0.1146
Leishmania major phosphatidylinositol 3-kinase, putative 0.0371 0.3177 0.3177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.5869 0.5826
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0071 0.0397 0.0397
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0071 0.0397 0.0253
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1108 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0071 0.0397 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0163 0.0015
Schistosoma mansoni immunophilin 0.0167 0.1278 0.1147
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0371 0.3177 0.3089
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0148 0.0148
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0167 0.1278 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.3177 0.3107
Echinococcus granulosus expressed conserved protein 0.0112 0.077 0.0651
Brugia malayi CHE-14 protein 0.0051 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.79 0.7878
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0397 0.0397
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0371 0.3177 0.3075
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0253
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0167 0.1278 0.1166
Loa Loa (eye worm) hypothetical protein 0.0119 0.0836 0.0836
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0049 0.019 0.0043
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0397 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.79 0.7878
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.021 0.1676 0.1551
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0397 0.0253
Echinococcus multilocularis serine protein kinase ATM 0.021 0.1676 0.1569
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0882 0.7908 0.7908
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0207 0.0081
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0397 0.0299
Leishmania major hypothetical protein, unknown function 0.0071 0.0397 0.0397
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0148 0.5
Loa Loa (eye worm) FKBP5 protein 0.0167 0.1278 0.1278
Schistosoma mansoni patched 1 0.0051 0.0207 0.006
Trypanosoma cruzi cytochrome P450, putative 0.007 0.0388 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.79 0.7878
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0524 0.4589 0.4508
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0836 0.0836
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0148 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.5278 0.5229
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0144 0.1066 0.0951
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0105 0.2637
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0071 0.0397 0.0253
Schistosoma mansoni fkbp-rapamycin associated protein 0.021 0.1676 0.1551
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0163 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0371 0.3177 0.3075
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0162 0.1236 0.1123
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1108 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0071 0.0397 0.0397
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0836 0.0719
Entamoeba histolytica protein kinase rad3, putative 0.021 0.1676 0.1676
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0397 0.0397
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0071 0.0397 0.0299
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0148 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.3177 0.3107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0719 0.6399 0.6362
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0397 0.0273
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0397 0.0253
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0397 1
Trypanosoma cruzi cytochrome P450, putative 0.007 0.0388 0.0243
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0397 0.0273
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0207 0.0081
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1108 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0148 0.0047
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1108 1 1
Loa Loa (eye worm) CYP4Cod1 0.007 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0162 0.1236 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.3177 0.3107
Echinococcus multilocularis protein patched 0.0051 0.0207 0.0081
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0397 0.0299
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0167 0.1278 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.021 0.1676 0.1676
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0167 0.1278 0.1147
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0397 0.0273
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0071 0.0397 0.0397
Brugia malayi Inositol-1 0.0045 0.0148 0.0148
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0397 0.0397
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0388 0.0388
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0836 0.0836
Echinococcus multilocularis fk506 binding protein 0.0167 0.1278 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Loa Loa (eye worm) hypothetical protein 0.021 0.1676 0.1676
Leishmania major cytochrome p450-like protein 0.007 0.0388 0.0388
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0167 0.1278 0.1278
Entamoeba histolytica hypothetical protein 0.0071 0.0397 0.0397
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0167 0.1278 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.021 0.1676 0.1591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.79 0.7878
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.5278 0.5229
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0071 0.0397 0.0253
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0397 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.5269 0.5221
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0371 0.3177 0.3089
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.021 0.1676 0.1551
Giardia lamblia GTOR 0.1108 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0397 0.0253
Echinococcus granulosus serine protein kinase ATM 0.021 0.1676 0.1569
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0397 0.0345
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0167 0.1278 0.0918
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0071 0.0397 0.0273
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1309 0.1197
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0071 0.0397 0.0253
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0148 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.1898 0.1815
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0743 0.662 0.6586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0397 0.0397
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0167 0.1278 0.1278
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0071 0.0397 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Loa Loa (eye worm) hypothetical protein 0.0071 0.0397 0.0397
Leishmania major phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0397
Echinococcus multilocularis expressed conserved protein 0.0112 0.077 0.0651
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0397 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.737 0.7343
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0397 0.0345
Schistosoma mansoni hypothetical protein 0.0049 0.019 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0071 0.0397 0.0253
Toxoplasma gondii target of rapamycin (TOR), putative 0.0824 0.737 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0233 0.1898 0.2423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1108 1 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0397
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0071 0.0397 0.0273
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0253
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0167 0.1278 0.1166
Echinococcus multilocularis protein dispatched 1 0.0058 0.0274 0.0149
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0071 0.0397 0.0253
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0167 0.1278 0.1189
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0207 0.0107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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