Detailed information for compound 1434519

Basic information

Technical information
  • TDR Targets ID: 1434519
  • Name: AQ-390/42132638
  • MW: 353.756 | Formula: C19H12ClNO4
  • H donors: 1 H acceptors: 4 LogP: 4.7 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(O)nc2c3c1c1ccccc1C(=O)c3c(cc2)Cl
  • InChi: 1S/C19H12ClNO4/c1-2-25-19(24)16-13-9-5-3-4-6-10(9)17(22)14-11(20)7-8-12(15(13)14)21-18(16)23/h3-8H,2H2,1H3,(H,21,23)
  • InChiKey: CELQOEJPNANKNS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • IDI1_023820
  • ZINC02503429
  • ChemDiv3_005910
  • MLS000704595
  • SMR000231990
  • ethyl 6-chloro-2,7-dioxo-2,7-dihydro-3H-naphtho[1,2,3-de]quinoline-1-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum ULP1 like chllamydin domain containing protease Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis sentrin specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Plasmodium knowlesi sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum sentrin-specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_127954 All targets in OG5_127954
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Schistosoma japonicum ko:K08592 sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii similar to sentrin/SUMO-specific protease Get druggable targets OG5_127954 All targets in OG5_127954
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_127954 All targets in OG5_127954
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_127954 All targets in OG5_127954
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus sentrin specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Plasmodium berghei sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_127954 All targets in OG5_127954
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0035 0.0326 0.1185
Onchocerca volvulus 0.0009 0.0014 0.0023
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0131 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0326 0.0533
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0014 0.0011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0014 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0247
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0088 0.0081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0081 0.0075
Mycobacterium ulcerans DNA gyrase subunit B 0.0028 0.024 0.5251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0014 0.0007
Schistosoma mansoni histamine h1 receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Onchocerca volvulus 0.0019 0.0131 0.046
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0007
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.024 0.0326
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0131 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0056 0.0583 0.0963
Onchocerca volvulus 0.001 0.0025 0.0066
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0028 0.024 0.5251
Brugia malayi hypothetical protein 0.0009 0.0007 0.0001
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0007
Schistosoma mansoni endoplasmin 0.0028 0.024 0.0234
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0014 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0503 0.5995 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0081 0.0075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0326 0.1089
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0557 0.055
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0131 0.0207
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0007 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0326 0.121
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0747 0.2774
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) heat shock protein 90 0.0028 0.024 0.039
Plasmodium falciparum heat shock protein 90 0.0028 0.024 0.2772
Echinococcus granulosus somatostatin receptor 0.0009 0.0014 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0014 0.0007
Trichomonas vaginalis Sentrin-specific protease, putative 0.0016 0.009 0.0336
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0014 0.0011
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0071 0.0064
Trichomonas vaginalis endoplasmin, putative 0.0028 0.024 0.0894
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0042 0.0416 0.041
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0326 0.121
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0028 0.024 0.039
Mycobacterium tuberculosis Conserved protein 0.0035 0.0326 0.1089
Schistosoma mansoni hypothetical protein 0.0165 0.1897 0.1892
Trypanosoma brucei DNA topoisomerase ii 0.0028 0.024 0.039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0489 0.0805
Echinococcus granulosus sentrin specific protease 7 0.0016 0.009 0.0084
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.2032 0.3338
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Mycobacterium tuberculosis Possible two component sensor kinase 0.0028 0.024 0.0757
Loa Loa (eye worm) hypothetical protein 0.0091 0.0999 0.1657
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0326 0.3988
Brugia malayi ecdysteroid receptor 0.0015 0.0081 0.0125
Echinococcus granulosus Ankyrin 0.0014 0.0072 0.0066
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0007
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0014 0.0011
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Brugia malayi Synaptic glycoprotein SC2 0.0042 0.0416 0.0684
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0028 0.024 0.039
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.024 0.0326
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1102 0.1096
Brugia malayi Dopamine receptor protein 1 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0495
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0028 0.024 0.5251
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0088 0.0081
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.1546
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0298 0.1106
Brugia malayi putative neuropeptide receptor 0.0009 0.0014 0.0011
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1286 0.4761
Brugia malayi RE15519p 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Schistosoma mansoni nAChR subunit 0.0009 0.0007 0.0001
Leishmania major developmentally regulated phosphoprotein-like protein 0.0503 0.5995 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2611 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0087 0.0135
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0014 0.0007
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0131 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0028 0.024 0.5251
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.024 0.0989
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0007 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0298 0.1106
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.024 0.0894
Onchocerca volvulus 0.0019 0.0131 0.046
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0081 0.0075
Plasmodium falciparum sentrin-specific protease 1 0.0056 0.0583 0.7667
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0208 0.0337
Schistosoma mansoni hypothetical protein 0.0033 0.0303 0.0296
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0131 0.0124
Loa Loa (eye worm) inositol-1 0.0036 0.0337 0.0551
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0081 0.0075
Brugia malayi GnHR receptor homolog 0.0009 0.0014 0.0011
Mycobacterium ulcerans two component regulator - sensor kinase 0.0028 0.024 0.5251
Echinococcus multilocularis GPCR, family 2 0.0015 0.0087 0.0081
Brugia malayi kinase, mitochondrial precursor 0.0503 0.5995 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0081 0.0125
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0208 0.0853
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0025 0.0031
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0088 0.0161
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0014 0.0007
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0208 0.0774
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0007 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0131 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0747 0.2774
Brugia malayi Dopamine receptor protein 2 0.0009 0.0014 0.0011
Plasmodium falciparum M18 aspartyl aminopeptidase 0.007 0.0747 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0007 0.0001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0131 0.0207
Mycobacterium tuberculosis Probable two component sensor kinase 0.0028 0.024 0.0757
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0014 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0131 0.0207
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0081 0.0075
Mycobacterium ulcerans lipase LipD 0.0035 0.0326 0.7553
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0014 0.0007
Brugia malayi Probable DNA topoisomerase II 0.0028 0.024 0.039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0081 0.0276
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0081 0.0125
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0028 0.024 1
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.007 0.0747 0.2731
Loa Loa (eye worm) amidase 0.0012 0.0046 0.0066
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1286 0.128
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0081
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Trypanosoma brucei aspartyl aminopeptidase, putative 0.007 0.0747 0.1236
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0131 0.0124
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0081 0.0276
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0042 0.0416 0.32
Brugia malayi nuclear hormone receptor 0.0015 0.0081 0.0125
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0081
Brugia malayi beta-lactamase family protein 0.0035 0.0326 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0081 0.0125
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0253 0.0247
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3541
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0014 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0081 0.0075
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0028 0.024 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0135
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Brugia malayi hypothetical protein 0.0009 0.0007 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0014 0.0011
Brugia malayi sulfakinin receptor protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0208 0.1576
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0081 0.0075
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3541
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0028 0.024 0.0234
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0014 0.0011
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0042 0.0416 0.041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.014
Onchocerca volvulus 0.0009 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0042 0.0416 0.0684
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0093 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0081 0.0075
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0042 0.0416 0.1546
Plasmodium vivax DNA gyrase subunit B, putative 0.0028 0.024 0.2772
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0014 0.0011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0088 0.0081
Onchocerca volvulus 0.0029 0.0253 0.0916
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0025 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0081 0.0125
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0042 0.0416 0.32
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0093 0.0086
Entamoeba histolytica hypothetical protein 0.001 0.0025 0.0143
Schistosoma mansoni pyruvate dehydrogenase 0.0503 0.5995 0.5992
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0025 0.0018
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0503 0.5995 0.5992
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0387 0.0635
Schistosoma mansoni flap endonuclease-1 0.0023 0.0179 0.0172
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0028 0.024 0.0757
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.007 0.0747 0.1177
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0071 0.0064
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0014 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Entamoeba histolytica hypothetical protein 0.0042 0.0416 0.32
Chlamydia trachomatis DNA gyrase subunit B 0.0028 0.024 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0007 0.0001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0291 0.3493
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0366 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Brugia malayi Endoplasmin precursor 0.0028 0.024 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0014 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0081 0.0075
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.0654
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Onchocerca volvulus Putative nachr subunit 0.0019 0.0131 0.046
Onchocerca volvulus 0.0019 0.0131 0.046
Brugia malayi Melatonin receptor type 1A 0.0009 0.0014 0.0011
Brugia malayi Protein kinase domain containing protein 0.0015 0.0078 0.0118
Brugia malayi Cation transporter family protein 0.0019 0.0131 0.0207
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1286 0.128
Mycobacterium ulcerans beta-lactamase 0.0035 0.0326 0.7553
Loa Loa (eye worm) hypothetical protein 0.0048 0.0489 0.0805
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Giardia lamblia Synaptic glycoprotein SC2 0.0042 0.0416 0.2725
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Amidase family protein 0.0012 0.0046 0.0066
Echinococcus multilocularis sentrin specific protease 1 0.0056 0.0583 0.0577
Brugia malayi Serotonin receptor 0.0009 0.0014 0.0011
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0028 0.024 1
Brugia malayi Uncoordinated protein 44 0.0014 0.0071 0.0107
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0007 0.0001
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.0557 0.055
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0131 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0081 0.0125
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0014 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0081 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0028 0.024 0.0757
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Echinococcus multilocularis aspartyl aminopeptidase 0.007 0.0747 0.074
Echinococcus granulosus nAChR subunit 0.001 0.0025 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0014 0.0007
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0014 0.0007
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.007 0.0747 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0014 0.0011
Brugia malayi Flap endonuclease-1 0.0025 0.0208 0.0337
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0007 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Plasmodium falciparum endoplasmin, putative 0.0028 0.024 0.2772
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.1546
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0028 0.024 0.0869
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0007
Echinococcus granulosus death domain containing protein 0.0014 0.0071 0.0064
Mycobacterium ulcerans putative regultory protein 0.0028 0.024 0.5251
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.0488
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.009 0.0336
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0298 0.1106
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.024 0.0869
Plasmodium vivax DNA topoisomerase II, putative 0.0028 0.024 0.2772
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0028 0.024 0.0869
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0131 0.0207
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0088 0.0342
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0007 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0088 0.0069
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0131 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0326 0.1089
Echinococcus multilocularis serotonin receptor 0.0009 0.0014 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0081 0.0125
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0014 0.0023
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Giardia lamblia Pms1-like protein 0.0028 0.024 0.1256
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0337 0.1251
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Echinococcus granulosus sentrin specific protease 1 0.0056 0.0583 0.0577
Brugia malayi Death domain containing protein 0.0014 0.0071 0.0107
Trypanosoma brucei Heat shock protein 83, putative 0.0028 0.024 0.039
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0298 0.1106
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0042 0.0416 0.1546
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0416 0.1546
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0007 0.0001
Onchocerca volvulus 0.0009 0.0014 0.0023
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0028 0.024 0.0757
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.007 0.0747 0.074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0081 0.0075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0081 0.0075
Mycobacterium leprae Probable two-component sensor kinase 0.0028 0.024 0.2772
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0014 0.0007
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0007 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0326 0.0533
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0014 0.0007
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0071 0.0064
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3584
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0014 0.0007
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.024 0.1256
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0088 0.0081
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Entamoeba histolytica heat shock protein 90, putative 0.0028 0.024 0.1828
Leishmania major DNA topoisomerase ii 0.0028 0.024 0.0326
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0081 0.0075
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.0551
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0014 0.0007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0028 0.024 0.0757
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0028 0.024 0.5251
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0131 0.0124
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0028 0.024 0.6689
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0014 0.0011
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0015 0.0081 0.0276
Plasmodium falciparum DNA gyrase subunit B 0.0028 0.024 0.2772
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0298 0.1106
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0014 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0081 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0337 0.1251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.0654
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1286 0.2136
Brugia malayi Inositol-1 0.0036 0.0337 0.0551
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1286 0.2136
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Cation transporter family protein 0.0019 0.0131 0.0207
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1286 0.2084
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0588 0.2185
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0337 0.1396
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0131 0.0207
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0131 0.0124
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0291 0.0954
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0208 0.0986
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0091 0.0999 0.1657
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0016 0.009 0.0336
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.528
Loa Loa (eye worm) Ulp1 protease 0.0016 0.009 0.014
Schistosoma mansoni netrin receptor unc5 0.0014 0.0071 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0081 0.0075
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0081 0.0125
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0503 0.5995 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0326 0.121
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0028 0.024 0.6689
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0081 0.0075
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.0654
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0131 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0088 0.0589
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0014 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0416 0.1546
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0014 0.0023
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.024 0.0326
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0326 0.0319
Echinococcus multilocularis geminin 0.0165 0.1897 0.1892
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0014 0.0011
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0081 0.0125
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.0557 0.055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0081 0.0125
Onchocerca volvulus 0.023 0.2693 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0337 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Schistosoma mansoni fatty-acid amide hydrolase 0.0099 0.1102 0.1096
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0337 0.2579
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0088 0.0135
Schistosoma mansoni myosin xvIII 0.0009 0.0014 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0087 0.0135
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0131 0.0124
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.0488
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0014 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0072 0.0066
Brugia malayi Amidase family protein 0.0012 0.0046 0.0066
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0007 0.0001
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0326 0.7553
Brugia malayi ORL1-like opioid receptor 0.0009 0.0014 0.0011
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0028 0.024 0.0757
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0014 0.0007
Brugia malayi Serotonin receptor 0.0009 0.0014 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0081 0.0075
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0056 0.0583 0.0577
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1286 0.2084
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.009 0.0354
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0016 0.009 0.2265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Plasmodium vivax sentrin-specific protease 1, putative 0.0056 0.0583 0.7667
Brugia malayi neuropeptide F receptor 0.0009 0.0014 0.0011
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.007 0.0747 0.074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0087 0.0081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0007 0.0001
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0088 0.0589
Loa Loa (eye worm) hypothetical protein 0.0038 0.0366 0.06
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0326 0.3988
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0081 0.0125
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0007 0.0001
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus granulosus fatty acid amide hydrolase 1 0.0012 0.0046 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Echinococcus granulosus aspartyl aminopeptidase 0.007 0.0747 0.074
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0337 0.7849
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0014 0.0007
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0503 0.5995 0.5992
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0087 0.0081
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0366 0.0359
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0028 0.024 0.5251
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.024 0.0326
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.024 0.0894
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0131 0.0124
Echinococcus multilocularis nAChR subunit 0.0019 0.0131 0.0124
Brugia malayi G protein-coupled receptor 0.0009 0.0014 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0014 0.0007
Trypanosoma brucei developmentally regulated phosphoprotein 0.0503 0.5995 1
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Mycobacterium leprae Probable lipase LipE 0.0035 0.0326 0.3988
Echinococcus granulosus allatostatin A receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0107
Echinococcus granulosus fmrfamide receptor 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Onchocerca volvulus 0.0009 0.0014 0.0023
Mycobacterium leprae Probable two component sensor kinase MprB 0.0028 0.024 0.2772
Mycobacterium tuberculosis Conserved protein 0.0035 0.0326 0.1089
Schistosoma mansoni heat shock protein 0.0028 0.024 0.0234
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0056 0.0583 0.2439
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0326 0.0319
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0081 0.0276
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0337 0.033
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0208 0.0337
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0081 0.0125
Echinococcus multilocularis heat shock protein 0.0028 0.024 0.0234
Onchocerca volvulus 0.0009 0.0014 0.0023
Echinococcus multilocularis somatostatin receptor 0.0009 0.0014 0.0007
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0131 0.0124
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0131 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0247
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Leishmania major hypothetical protein, conserved 0.0028 0.024 0.0326
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0093 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Toxoplasma gondii ABC1 family protein 0.0035 0.0326 0.1349
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0326 0.1089
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0012 0.0046 0.004
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0007 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0014 0.0007
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0042 0.0416 0.041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus multilocularis synaptic glycoprotein sc2 0.0042 0.0416 0.041
Brugia malayi G-protein coupled receptor 0.0009 0.0014 0.0011
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0093 0.0143
Schistosoma mansoni inositol monophosphatase 0.0036 0.0337 0.033
Onchocerca volvulus 0.0009 0.0014 0.0023
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0014 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.1546
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0014 0.0007
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0007
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0131 0.0207
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0014 0.0007
Entamoeba histolytica aspartyl aminopeptidase, putative 0.007 0.0747 0.5784
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0769 0.0763
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0208 0.0272
Brugia malayi G-protein coupled receptor 0.0009 0.0014 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0025 0.0031
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.009 0.0084
Onchocerca volvulus 0.0019 0.0131 0.046
Brugia malayi hypothetical protein 0.0009 0.0007 0.0001
Trypanosoma brucei polo-like protein kinase 0.0114 0.1286 0.2136
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0081 0.0125
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.2032 0.3382
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Onchocerca volvulus 0.0035 0.0326 0.1185
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0056 0.0583 0.0577
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0088 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Echinococcus granulosus sex peptide receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0131 0.0207
Trichomonas vaginalis receptor histidine kinase, putative 0.0028 0.024 0.0894
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Echinococcus granulosus flap endonuclease 1 0.0025 0.0208 0.0202
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Onchocerca volvulus 0.0009 0.0014 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0081 0.0075
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0131 0.0124
Onchocerca volvulus 0.0019 0.0131 0.046
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0326 0.121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0081 0.0125
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.024 0.0326
Trypanosoma cruzi hypothetical protein 0.0016 0.009 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Schistosoma mansoni coup transcription factor 0.0015 0.0081 0.0075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2353 0.3918
Loa Loa (eye worm) hypothetical protein 0.0042 0.0416 0.0684
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0028 0.024 0.6689
Loa Loa (eye worm) hypothetical protein 0.007 0.0747 0.1236
Loa Loa (eye worm) hypothetical protein 0.007 0.0747 0.1236
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0028 0.024 0.039
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0081 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Schistosoma mansoni unc-13 (munc13) 0.0009 0.001 0.0003
Mycobacterium ulcerans hypothetical protein 0.0042 0.0416 1
Plasmodium falciparum polyprenol reductase, putative 0.0042 0.0416 0.528
Brugia malayi beta-lactamase family protein 0.0035 0.0326 0.0533
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Echinococcus multilocularis sentrin specific protease 8 0.0016 0.009 0.0084
Brugia malayi hypothetical protein 0.0009 0.0007 0.0001
Brugia malayi Cation transporter family protein 0.0019 0.0131 0.0207
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.014
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0253 0.0247
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0028 0.024 0.0757
Schistosoma mansoni heat shock protein 0.0028 0.024 0.0234
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0014 0.0007
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.024 0.0989
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0081 0.0075
Plasmodium vivax SET domain protein, putative 0.0029 0.0253 0.2953
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0131 0.0207
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0769 0.0763
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0088 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0298 0.1106
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0014 0.0011
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.009 0.0354
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0028 0.024 0.0757
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0081 0.0075
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Onchocerca volvulus 0.0035 0.0326 0.1185
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1102 0.1096
Plasmodium falciparum flap endonuclease 1 0.0025 0.0208 0.2312
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0099 0.1102 0.1829
Echinococcus granulosus heat shock protein 0.0028 0.024 0.0234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0088 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0081 0.0125
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0007
Plasmodium falciparum DNA topoisomerase 2 0.0028 0.024 0.2772
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3584
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0014 0.0007
Chlamydia trachomatis DNA gyrase subunit B 0.0028 0.024 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0081 0.0075
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0204 0.2371 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0016 0.009 0.2265
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0014 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0131 0.0207
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0014 0.0007
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0016 0.009 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0028 0.024 0.2772
Leishmania major mitochondrial DNA topoisomerase II 0.0028 0.024 0.0326
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0087 0.0081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0007 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.011
Brugia malayi heat shock protein 90 0.0028 0.024 0.039
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0014 0.0007
Plasmodium vivax polyprenol reductase, putative 0.0042 0.0416 0.528
Onchocerca volvulus 0.0009 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Onchocerca volvulus 0.001 0.0025 0.0066
Plasmodium vivax heat shock protein 86, putative 0.0028 0.024 0.2772
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.0684
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0042 0.0416 0.1546
Schistosoma mansoni hypothetical protein 0.0165 0.1897 0.1892
Onchocerca volvulus 0.0009 0.0014 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0088 0.0342
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trypanosoma brucei heat shock protein 90, putative 0.0028 0.024 0.039
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0131 0.0124
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0028 0.024 0.0894
Onchocerca volvulus 0.0009 0.0014 0.0023
Brugia malayi neuropeptide F receptor 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0056 0.0583 0.4507
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0253 0.1043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0071 0.0064
Trichomonas vaginalis heat shock protein, putative 0.0028 0.024 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0007
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Brugia malayi steroid hormone receptor 0.0015 0.0081 0.0125
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0028 0.024 0.2772
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0014 0.0007
Echinococcus granulosus GPCR family 2 0.0015 0.0087 0.0081
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.007 0.0747 0.2774
Schistosoma mansoni hypothetical protein 0.0014 0.0071 0.0064
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0081 0.0075
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0056 0.0583 0.2167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.039
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Trypanosoma brucei aspartyl aminopeptidase, putative 0.007 0.0747 0.1236
Echinococcus granulosus heat shock protein 90 0.0028 0.024 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Mycobacterium tuberculosis Conserved protein 0.0028 0.024 0.0757
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0131 0.0207
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0014 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0042 0.0416 0.1732
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0042 0.0416 0.041
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0007
Schistosoma mansoni DNA topoisomerase II 0.0028 0.024 0.0234
Trypanosoma brucei heat shock protein 90, putative 0.0028 0.024 0.039
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0081
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0028 0.024 0.0326
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0208 0.0202
Plasmodium vivax endoplasmin, putative 0.0028 0.024 0.2772
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0088 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0253 0.0247
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0081 0.0125
Loa Loa (eye worm) endoplasmin 0.0028 0.024 0.039
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0303 0.0495
Leishmania major sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3541
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.007 0.0747 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0253 0.0412
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0131 0.0124
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0131 0.0124
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0028 0.024 0.0894
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0131 0.0207
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0042 0.0416 0.32
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0014 0.0007
Entamoeba histolytica heat shock protein 90, putative 0.0028 0.024 0.1828
Schistosoma mansoni nAChR subunit 0.0009 0.0007 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0014 0.0007
Schistosoma mansoni amidase 0.0099 0.1102 0.1096
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0081 0.0075
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0131 0.0207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0125
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0088 0.0135
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) beta-lactamase 0.0035 0.0326 0.0533
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0131 0.0207
Trypanosoma cruzi Heat shock protein 83, putative 0.0028 0.024 0.0326
Brugia malayi Dopamine receptor 0.0009 0.0014 0.0011
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.024 0.0326
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0253 0.0247
Echinococcus granulosus orexin receptor type 2 0.0009 0.0014 0.0007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0071 0.0107
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0007
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0208 0.2312
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0014 0.0007
Brugia malayi larval opioid receptor 0.0009 0.0014 0.0011
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Brugia malayi Protein kinase c protein 2 0.0046 0.0458 0.0754
Loa Loa (eye worm) aspartyl aminopeptidase 0.007 0.0747 0.1236
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Trichomonas vaginalis esterase, putative 0.0035 0.0326 0.121
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.007 0.0747 0.1177
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Schistosoma mansoni atypical protein kinase C 0.0015 0.0078 0.0071
Brugia malayi protein kinase C II. 0.0016 0.0093 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0326 0.0319
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0176 0.2032 0.3338
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0042 0.0416 0.0622
Brugia malayi AKH receptor 0.0009 0.0014 0.0011
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1102 0.1096
Mycobacterium tuberculosis Conserved protein 0.0035 0.0326 0.1089
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0014 0.0011
Trypanosoma brucei SUMO1/Ulp2, putative 0.0016 0.009 0.014
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.024 0.0234
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0588 0.2185
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0007
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0014 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0081 0.0125
Loa Loa (eye worm) TOPoisomerase family member 0.0028 0.024 0.039
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0014 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0016 0.009 0.0074
Echinococcus multilocularis heat shock protein 90 0.0028 0.024 0.0234
Schistosoma mansoni fatty-acid amide hydrolase 0.0012 0.0046 0.004
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis sentrin specific protease 7 0.0016 0.009 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Echinococcus granulosus neuropeptide receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0014 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1286 0.2084
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0486 0.0479
Echinococcus granulosus sentrin specific protease 8 0.0016 0.009 0.0084
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0081 0.0075
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0131 0.0124
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi nuclear receptor NHR-88 0.0015 0.0081 0.0125
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0014 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0081 0.0125
Giardia lamblia Kinase, PLK 0.0114 0.1286 1
Echinococcus granulosus geminin 0.0165 0.1897 0.1892
Onchocerca volvulus 0.0009 0.0014 0.0023
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.007 0.0747 0.1177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0081 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0337 0.0488
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0014 0.0007
Trichomonas vaginalis hypothetical protein 0.0033 0.0298 0.1106
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0012 0.0046 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0007
Trichomonas vaginalis set domain proteins, putative 0.023 0.2692 1
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Echinococcus multilocularis Ankyrin 0.0014 0.0072 0.0066
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0088 0.0069
Entamoeba histolytica DNA topoisomerase II, putative 0.0028 0.024 0.1828
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0012 0.0046 0.004
Schistosoma mansoni endoplasmin 0.0028 0.024 0.0234
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0042 0.0416 0.1732
Trypanosoma brucei Sterol methyltransferase, putative 0.0186 0.2153 0.3584
Echinococcus multilocularis serotonin receptor 0.0009 0.0014 0.0007
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0071 0.0237
Schistosoma mansoni nAChR subunit 0.0019 0.0131 0.0124
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.0622
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0007
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0014 0.0007
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.0622
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.528
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0326 0.121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0489 0.0805
Brugia malayi hypothetical protein 0.0009 0.0014 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.0654
Schistosoma mansoni kinase 0.0058 0.0606 0.06
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0028 0.024 0.2772
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0326 0.0533
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.009 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0081 0.0075
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.024 0.0326
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0088 0.0069
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0028 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0437 0.0718
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0131 0.0124
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0131 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0014 0.0007
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.024 0.0326
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0007
Leishmania major hypothetical protein, conserved 0.0035 0.0326 0.0469
Toxoplasma gondii heat shock protein HSP90 0.0028 0.024 0.0989
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1286 0.4778
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0081 0.0075
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0042 0.0416 0.0684
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0014 0.0007
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.014
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0028 0.024 0.039
Toxoplasma gondii heat shock protein 90, putative 0.0028 0.024 0.0989
Loa Loa (eye worm) hypothetical protein 0.0056 0.0583 0.0963
Echinococcus multilocularis sex peptide receptor 0.0009 0.0014 0.0007
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0046 0.004
Onchocerca volvulus 0.0019 0.0131 0.046
Brugia malayi Aspartyl aminopeptidase 0.007 0.0747 0.1236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0131 0.0207
Echinococcus multilocularis protein kinase c iota type 0.0015 0.0078 0.0071
Loa Loa (eye worm) Ulp1 protease 0.0016 0.009 0.014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Schistosoma mansoni adenoreceptor 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0326 0.1089
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0503 0.5995 0.5992
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0131 0.0207
Plasmodium vivax sentrin-specific protease 2, putative 0.0016 0.009 0.0628
Plasmodium vivax hypothetical protein, conserved 0.0028 0.024 0.2772
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0326 0.1089
Trypanosoma brucei heat shock protein, putative 0.0028 0.024 0.039
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.0622
Echinococcus granulosus nAChR subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0016 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0031
Loa Loa (eye worm) amidase 0.0012 0.0046 0.0066
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1102 0.1096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0131 0.0207
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0014 0.0007
Onchocerca volvulus 0.0009 0.0014 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.024 0.0326
Brugia malayi hypothetical protein 0.0009 0.0007 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0326 0.0319
Brugia malayi isocitrate dehydrogenase 0.0015 0.0088 0.0135
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0326 0.1089
Brugia malayi putative amidase 0.0012 0.0046 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0007
Mycobacterium ulcerans two component sensor kinase MprB 0.0028 0.024 0.5251
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0131 0.0207
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0014 0.0007
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0025 0.0018
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0014 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0326 0.7553
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0042 0.0416 0.1732
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0337 0.1251
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0176 0.2032 0.8566
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0253 0.0247
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0557 0.055
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0326 0.0469
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0028 0.024 0.0894
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0131 0.0207
Echinococcus granulosus neuropeptide receptor 0.0009 0.0014 0.0007
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0014 0.0007
Echinococcus granulosus protein kinase c iota type 0.0015 0.0078 0.0071
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0025 0.0031
Echinococcus granulosus hypothetical protein 0.0009 0.0014 0.0007
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0028 0.024 0.0757
Trichomonas vaginalis DNA topoisomerase II, putative 0.0028 0.024 0.0894
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0337 0.033
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0028 0.024 0.0234
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0042 0.0416 0.1546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0253 0.0412
Trichomonas vaginalis sensor histidine kinase, putative 0.0028 0.024 0.0894
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0014 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0081 0.0125
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0208 0.0272
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1286 0.128
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0071 0.0064
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0028 0.024 0.5251
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0014 0.0007
Echinococcus multilocularis nAChR subunit 0.001 0.0025 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0489 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0081 0.0125
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0097 0.1076 0.1785
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0014 0.0007
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0028 0.024 0.5251
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0088 0.0081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3541
Schistosoma mansoni pyruvate dehydrogenase 0.0475 0.5656 0.5653
Toxoplasma gondii DNA topoisomerase 2, putative 0.0028 0.024 0.0989
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0416 0.0684
Leishmania major heat shock protein 83-1 0.0028 0.024 0.0326
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0028 0.024 0.0757
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0028 0.024 0.5251
Echinococcus granulosus synaptic glycoprotein sc2 0.0042 0.0416 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0014 0.0011
Onchocerca volvulus 0.0042 0.0416 0.1522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1286 1
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0486 0.0479
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0131 0.0124
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0416 0.0684
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0012 0.0046 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0071 0.0107
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0326 0.1089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0087 0.0081
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0028 0.024 0.0894
Brugia malayi beta-lactamase 0.0035 0.0326 0.0533
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0326 0.0469
Echinococcus granulosus serotonin receptor 0.0009 0.0014 0.0007
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0028 0.024 0.039
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0087 0.0135
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0014 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0081 0.0075
Mycobacterium ulcerans hypothetical protein 0.0035 0.0326 0.7553
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0366 0.0359
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Brugia malayi amidase 0.0099 0.1102 0.1829
Entamoeba histolytica aminopeptidase, putative 0.007 0.0747 0.5784
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.009 0.014
Schistosoma mansoni pyruvate dehydrogenase 0.0475 0.5656 0.5653
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0014 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0016 0.009 0.0074
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0028 0.024 0.0757
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0011
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0028 0.024 0.0757
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.009 0.0336
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0337 1
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0007
Brugia malayi Pre-SET motif family protein 0.0202 0.2353 0.3918
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0014 0.0007
Leishmania major sterol 24-c-methyltransferase, putative 0.0186 0.2153 0.3541

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 2.75 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 18.3 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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