Detailed information for compound 1445725

Basic information

Technical information
  • TDR Targets ID: 1445725
  • Name: 9-hydrazinylidene-N,N'-bis(2-hydroxyethyl)-N, N'-dimethylfluorene-2,7-disulfonamide
  • MW: 468.547 | Formula: C19H24N4O6S2
  • H donors: 3 H acceptors: 6 LogP: -0.08 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(S(=O)(=O)c1ccc2c(c1)C(=NN)c1c2ccc(c1)S(=O)(=O)N(CCO)C)C
  • InChi: 1S/C19H24N4O6S2/c1-22(7-9-24)30(26,27)13-3-5-15-16-6-4-14(31(28,29)23(2)8-10-25)12-18(16)19(21-20)17(15)11-13/h3-6,11-12,24-25H,7-10,20H2,1-2H3
  • InChiKey: XGNWNVISVJWRDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-hydrazono-N,N'-bis(2-hydroxyethyl)-N,N'-dimethyl-fluorene-2,7-disulfonamide
  • 9-hydrazono-N,N'-bis(2-hydroxyethyl)-N,N'-dimethylfluorene-2,7-disulfonamide
  • 9-hydrazinylidene-N,N'-bis(2-hydroxyethyl)-N,N'-dimethyl-fluorene-2,7-disulfonamide
  • Oprea1_061629

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Echinococcus multilocularis Fibronectin, type III 0.0081 0.1741 0.1989
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0081 0.1741 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.087 0.0994
Onchocerca volvulus 0.0133 0.3628 0.5814
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0989 0.5679
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0081 0.1741 0.1658
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0747 0.1068
Onchocerca volvulus 0.0053 0.0747 0.1068
Schistosoma mansoni myosin-binding protein-related 0.0133 0.3628 0.4348
Brugia malayi SH2 domain containing protein 0.0041 0.0341 0.0244
Onchocerca volvulus 0.0038 0.0205 0.0176
Onchocerca volvulus 0.0041 0.0341 0.0398
Echinococcus multilocularis titin 0.0081 0.1741 0.1989
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Brugia malayi Muscleblind-like protein 0.018 0.5304 0.5257
Brugia malayi intracellular kinase 0.0056 0.087 0.0779
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.101 0.0921
Trypanosoma brucei protein kinase, putative 0.0056 0.087 0.4999
Brugia malayi Prion-like- 0.0053 0.0747 0.0655
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.014 0.3864 0.4414
Loa Loa (eye worm) hypothetical protein 0.006 0.101 0.0921
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.101 0.0921
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0989 0.1185
Brugia malayi Protein kinase domain containing protein 0.0178 0.5229 0.5182
Echinococcus granulosus leucine rich repeat containing protein 4 0.0053 0.0747 0.0854
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.3864 0.3803
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1207 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0059 0.0983 0.1179
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0053 0.0747 0.0854
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.1741 0.1658
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Echinococcus granulosus contactin 0.014 0.3864 0.4414
Schistosoma mansoni tyrosine kinase 0.0041 0.0341 0.0408
Echinococcus granulosus Netrin receptor DCC 0.0081 0.1741 0.1989
Echinococcus granulosus hemicentin 1 0.0059 0.0983 0.1123
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0747 0.0655
Echinococcus multilocularis tyrosine protein kinase Abl 0.0143 0.3957 0.452
Schistosoma mansoni septate junction protein 0.0059 0.0983 0.1179
Schistosoma mansoni tyrosine kinase 0.0266 0.8344 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus multilocularis muscleblind protein 0.018 0.5304 0.6059
Brugia malayi hypothetical protein 0.0101 0.2466 0.239
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Schistosoma mansoni titin 0.0133 0.3628 0.4348
Schistosoma mansoni hypothetical protein 0.0041 0.033 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.1818 0.1737
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0087 0.1977 0.1897
Echinococcus granulosus cpg binding protein 0.0037 0.0169 0.0194
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0041 0.0341 0.0389
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus multilocularis plexin a4 0.0045 0.0452 0.0516
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Echinococcus granulosus lachesin 0.0059 0.0983 0.1123
Echinococcus multilocularis tyrosine protein kinase shark 0.0041 0.0341 0.0389
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.3864 0.3803
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0053 0.0747 0.0895
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0041 0.0341 0.0398
Schistosoma mansoni cell adhesion molecule 0.0133 0.3628 0.4348
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Echinococcus multilocularis anosmin 1 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Echinococcus multilocularis c src tyrosine kinase 0.0053 0.074 0.0846
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0081 0.1741 0.1989
Schistosoma mansoni titin 0.0135 0.3697 0.4431
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0053 0.0747 0.0854
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.014 0.3864 0.4414
Echinococcus granulosus tyrosine kinase 0.0075 0.153 0.1748
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0989 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0331 0.0396
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0989 0.819
Echinococcus granulosus titin 0.0135 0.3697 0.4223
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0989 0.013
Schistosoma mansoni slit 0.0053 0.0747 0.0895
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0081 0.1741 0.1658
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6563 0.6235
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1741 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0081 0.1741 0.1989
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.087 0.4999
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0989 0.5679
Onchocerca volvulus 0.0081 0.1741 0.2705
Schistosoma mansoni titin 0.0059 0.0983 0.1179
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 1 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.087 0.4999
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0053 0.0747 0.0854
Echinococcus multilocularis transfer RNA-Phe 0.0133 0.3628 0.4144
Brugia malayi myotactin form B 0.0081 0.1741 0.1658
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Brugia malayi Protein kinase domain containing protein 0.0041 0.0341 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6563 0.6235
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0075 0.153 0.1748
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0142 0.3933 0.3873
Loa Loa (eye worm) hypothetical protein 0.012 0.3148 0.3079
Echinococcus multilocularis geminin 0.0205 0.6169 0.7048
Loa Loa (eye worm) hypothetical protein 0.0101 0.2466 0.239
Loa Loa (eye worm) TK/EGFR protein kinase 0.0097 0.2318 0.2241
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.014 0.3864 0.4631
Loa Loa (eye worm) hypothetical protein 0.0041 0.033 0.0233
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.014 0.3864 0.4414
Loa Loa (eye worm) UNCoordinated family member 0.0081 0.1741 0.1658
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0747 0.0655
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1488 0.1783
Schistosoma mansoni neuroglian 0.014 0.3864 0.4631
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0989 0.5679
Onchocerca volvulus 0.0081 0.1741 0.2705
Echinococcus granulosus peroxidasin 0.0059 0.0983 0.1123
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.087 0.0779
Brugia malayi Protein kinase domain containing protein 0.0041 0.0341 0.0244
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.2318 0.2648
Schistosoma mansoni tyrosine kinase 0.0086 0.193 0.2312
Schistosoma mansoni ephrin receptor 0.0111 0.2812 0.337
Onchocerca volvulus 0.0053 0.0747 0.1068
Onchocerca volvulus 0.0041 0.0341 0.0398
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0081 0.1741 0.1989
Brugia malayi Protein kinase domain containing protein 0.0041 0.0341 0.0244
Schistosoma mansoni tyrosine kinase 0.0053 0.074 0.0887
Echinococcus granulosus G1Y162 protein 0.0081 0.1741 0.1989
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.2318 0.2648
Echinococcus granulosus anosmin 1 0.0081 0.1741 0.1989
Onchocerca volvulus 0.0041 0.0341 0.0398
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Schistosoma mansoni factor for adipocyte differentiation 0.0081 0.1741 0.2086
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus fibronectin type III domain-containing protein 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus granulosus neuroglian 0.014 0.3864 0.4414
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Onchocerca volvulus 0.0081 0.1741 0.2705
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Onchocerca volvulus Netrin receptor homolog 0.0053 0.0747 0.1068
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.1818 0.1737
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Echinococcus multilocularis hemicentin 1 0.0059 0.0983 0.1123
Brugia malayi Lethal protein 805 0.0081 0.1741 0.1658
Echinococcus granulosus Fibronectin type III domain containing protein 0.0081 0.1741 0.1989
Echinococcus granulosus anosmin 1 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Onchocerca volvulus 0.0135 0.3697 0.5927
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0081 0.1741 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0086 0.193 0.2204
Loa Loa (eye worm) CAMK protein kinase 0.0135 0.3697 0.3634
Echinococcus granulosus tyrosine protein kinase shark 0.0041 0.0341 0.0389
Echinococcus granulosus roundabout 2 0.016 0.4589 0.5242
Onchocerca volvulus 0.0081 0.1741 0.2705
Onchocerca volvulus 0.0053 0.0747 0.1068
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0053 0.0747 0.0854
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0135 0.3697 0.3634
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0277 0.8754 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Loa Loa (eye worm) projectin 0.0133 0.3628 0.3564
Echinococcus granulosus insulin growth factor binding 0.0053 0.0747 0.0854
Onchocerca volvulus 0.0081 0.1741 0.2705
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0081 0.1741 0.1658
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Schistosoma mansoni tyrosine kinase 0.0041 0.0341 0.0408
Echinococcus granulosus tyrosine protein kinase otk 0.0059 0.0983 0.1123
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus multilocularis 0.0053 0.0747 0.0854
Echinococcus multilocularis titin 0.0053 0.0747 0.0854
Onchocerca volvulus 0.0053 0.0747 0.1068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Echinococcus granulosus insulin receptor 0.0178 0.5229 0.5974
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0459 0.0524
Loa Loa (eye worm) hypothetical protein 0.0101 0.2466 0.239
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Schistosoma mansoni plexin 0.0038 0.0205 0.0246
Schistosoma mansoni roundabout 0.0059 0.0983 0.1179
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0989 0.1129
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0041 0.0341 0.3041
Brugia malayi myotactin form A 0.0081 0.1741 0.1658
Echinococcus multilocularis roundabout 2 0.016 0.4589 0.5242
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0989 0.5679
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0081 0.1741 0.2086
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0081 0.1741 0.1658
Schistosoma mansoni tyrosine kinase 0.0089 0.2054 0.2462
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0081 0.1741 0.1658
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.1741 0.1658
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0747 0.1068
Echinococcus granulosus roundabout 2 0.014 0.3864 0.4414
Schistosoma mansoni tyrosine kinase 0.0053 0.074 0.0887
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus granulosus tyrosine protein kinase Src64B 0.0086 0.193 0.2204
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus tyrosine protein kinase Lyn 0.0088 0.1999 0.2283
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0081 0.1741 0.1658
Onchocerca volvulus 0.0053 0.0747 0.1068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0135 0.3697 0.3634
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.1741 0.1658
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.014 0.3864 0.3803
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Echinococcus multilocularis Netrin receptor DCC 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.008 0.1708 0.1625
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0081 0.1741 0.2086
Loa Loa (eye worm) SRC-1 0.0086 0.193 0.1849
Echinococcus granulosus titin 0.0053 0.0747 0.0854
Echinococcus granulosus tyrosine protein kinase Srms 0.0041 0.0341 0.0389
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0086 0.193 0.2204
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0053 0.074 0.0846
Brugia malayi hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus geminin 0.0205 0.6169 0.7048
Schistosoma mansoni tyrosine kinase 0.0086 0.193 0.2312
Echinococcus granulosus twitchin 0.0075 0.1541 0.176
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Schistosoma mansoni cpg binding protein 0.0037 0.0169 0.0203
Brugia malayi Protein kinase domain containing protein 0.0111 0.2843 0.2771
Schistosoma mansoni protein tyrosine phosphatase 0.0081 0.1741 0.2086
Schistosoma mansoni tyrosine kinase 0.0097 0.2318 0.2778
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0989 0.0899
Loa Loa (eye worm) hypothetical protein 0.0101 0.2466 0.239
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0989 0.5679
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.033 0.0233
Echinococcus multilocularis lachesin 0.0059 0.0983 0.1123
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0081 0.1741 0.1989
Loa Loa (eye worm) lethal protein 805 0.0081 0.1741 0.1658
Entamoeba histolytica protein kinase, putative 0.0063 0.112 1
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.087 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0081 0.1741 0.2086
Schistosoma mansoni cpg binding protein 0.0037 0.0169 0.0203
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Onchocerca volvulus Putative titin 0.0053 0.0747 0.1068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0177 0.1583
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0989 1
Echinococcus granulosus muscleblind protein 0.018 0.5304 0.6059
Echinococcus granulosus tyrosine protein kinase Src42A 0.0086 0.193 0.2204
Schistosoma mansoni tyrosine kinase 0.0067 0.1247 0.1494
Echinococcus granulosus c src tyrosine kinase 0.0053 0.074 0.0846
Echinococcus granulosus neuroglian 0.0073 0.1472 0.1681
Loa Loa (eye worm) hypothetical protein 0.0133 0.3628 0.3564
Schistosoma mansoni hypothetical protein 0.0081 0.1741 0.2086
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.087 0.5
Schistosoma mansoni nephrin 0.0154 0.4353 0.5216
Echinococcus granulosus tyrosine protein kinase ABL1 0.0277 0.8754 1
Echinococcus granulosus anosmin 1 0.0081 0.1741 0.1989
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.087 0.1043
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.153 0.1748
Schistosoma mansoni tyrosine kinase 0.0097 0.2318 0.2778
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus multilocularis neuroglian 0.0073 0.1472 0.1681
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0133 0.3628 0.4144
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0057 0.0892 0.0801
Loa Loa (eye worm) one IG domain family member 0.0053 0.0747 0.0655
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus tyrosine kinase 0.0041 0.0341 0.0389
Onchocerca volvulus 0.0081 0.1741 0.2705
Echinococcus multilocularis anosmin 1 0.0081 0.1741 0.1989
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.1741 0.1658
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0041 0.0341 0.0389
Echinococcus granulosus titin 0.0053 0.0747 0.0854
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0747 0.0655
Brugia malayi Myb-like DNA-binding domain containing protein 0.0053 0.0747 0.0655
Loa Loa (eye worm) hypothetical protein 0.018 0.5304 0.5257
Brugia malayi kettin 0.0053 0.0747 0.0655
Echinococcus multilocularis cpg binding protein 0.0037 0.0169 0.0194
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0259 0.811 0.9265
Echinococcus multilocularis peroxidasin 0.0059 0.0983 0.1123
Brugia malayi SRC-1 0.0086 0.193 0.1849
Leishmania major hypothetical protein, conserved 0.0081 0.1741 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Schistosoma mansoni titin 0.0053 0.0747 0.0895
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0133 0.3628 0.3564
Echinococcus multilocularis neuroglian 0.014 0.3864 0.4414
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0086 0.193 0.2204
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.3864 0.3803
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0053 0.0747 0.0655
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0053 0.0747 0.0854
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0081 0.1741 0.2705
Onchocerca volvulus 0.0053 0.0747 0.1068
Schistosoma mansoni titin 0.0053 0.0747 0.0895
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Echinococcus multilocularis muscleblind protein 1 0.018 0.5304 0.6059
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0081 0.1741 0.2705
Echinococcus granulosus Fibronectin type III 0.0081 0.1741 0.1989
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0989 0.1129
Loa Loa (eye worm) hypothetical protein 0.0082 0.1772 0.169
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0053 0.074 0.0887
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0081 0.1741 0.2705
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0892 0.0801
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0087 0.1977 0.2259
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Brugia malayi Furin-like cysteine rich region family protein 0.0097 0.2318 0.2241
Schistosoma mansoni factor for adipocyte differentiation 0.0081 0.1741 0.2086
Echinococcus multilocularis hemicentin 1 0.0059 0.0983 0.1123
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0133 0.3628 0.3564
Brugia malayi protein unc-22 0.0135 0.3697 0.3634
Loa Loa (eye worm) TK/INSR protein kinase 0.0178 0.5229 0.5182
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0087 0.1977 0.2259
Schistosoma mansoni hemicentin 0.0133 0.3628 0.4348
Echinococcus granulosus tyrosine protein kinase HCK 0.0063 0.112 0.128
Echinococcus granulosus down syndrome cell adhesion 0.0053 0.0747 0.0854
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1977 0.1897
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.014 0.3864 0.4414
Echinococcus multilocularis insulin receptor 0.0178 0.5229 0.5974
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0259 0.811 0.9265
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.087 0.7767
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Loa Loa (eye worm) TK protein kinase 0.0063 0.112 0.1032
Echinococcus granulosus titin 0.0135 0.3697 0.4223
Echinococcus multilocularis titin 0.0135 0.3697 0.4223
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.087 0.0994
Echinococcus multilocularis roundabout 2 0.014 0.3864 0.4414
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0059 0.0983 0.0893
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Loa Loa (eye worm) hypothetical protein 0.008 0.1708 0.1625
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.2318 0.2648
Onchocerca volvulus 0.0041 0.0341 0.0398
Onchocerca volvulus 0.0053 0.0747 0.1068
Echinococcus granulosus cell adhesion molecule 0.0081 0.1741 0.1989
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0083 0.1818 0.2077
Schistosoma mansoni cell adhesion molecule 0.0133 0.3628 0.4348
Schistosoma mansoni hypothetical protein 0.0081 0.1741 0.2086
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0081 0.1741 0.1989
Brugia malayi MAP kinase sur-1 0.006 0.0989 0.0899
Trypanosoma brucei protein kinase, putative 0.006 0.0989 0.5679
Brugia malayi Tyrosine-protein kinase abl-1 0.0145 0.4056 0.3997
Echinococcus granulosus nephrin 0.0133 0.3628 0.4144
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0059 0.0983 0.1457
Schistosoma mansoni hypothetical protein 0.0133 0.3628 0.4348
Schistosoma mansoni titin 0.0053 0.0747 0.0895
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Schistosoma mansoni nephrin related 0.0053 0.0747 0.0895
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.2318 0.2648
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0989 0.013
Brugia malayi SPRY domain containing protein 0.0081 0.1741 0.1658
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0081 0.1741 0.1658
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Loa Loa (eye worm) myotactin form A 0.0081 0.1741 0.1658
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0989 0.5679
Echinococcus multilocularis anosmin 1 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0177 0.1583
Onchocerca volvulus 0.0053 0.0747 0.1068
Loa Loa (eye worm) hypothetical protein 0.0041 0.0341 0.0244
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0133 0.3628 0.5814
Onchocerca volvulus 0.0081 0.1741 0.2705
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.087 0.7767
Schistosoma mansoni titin 0.0053 0.0747 0.0895
Echinococcus granulosus usherin 0.0081 0.1741 0.1989
Echinococcus granulosus plexin a4 0.0045 0.0452 0.0516
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Brugia malayi Lethal protein 805 0.0081 0.1741 0.1658
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0081 0.1741 0.1989
Echinococcus multilocularis tyrosine protein kinase Blk 0.0075 0.153 0.1748
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0081 0.1741 0.1989
Loa Loa (eye worm) hypothetical protein 0.0059 0.0983 0.0893
Schistosoma mansoni cell adhesion molecule 0.0053 0.0747 0.0895
Schistosoma mansoni cell adhesion molecule 0.0108 0.2702 0.3238
Schistosoma mansoni hypothetical protein 0.0053 0.0747 0.0895
Brugia malayi Prion-like- 0.0059 0.0983 0.0893
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Loa Loa (eye worm) TK protein kinase 0.0075 0.153 0.1445
Echinococcus multilocularis tyrosine protein kinase otk 0.0059 0.0983 0.1123
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.2318 0.2648
Brugia malayi Protein kinase domain containing protein 0.0041 0.0341 0.0244
Schistosoma mansoni hypothetical protein 0.0205 0.6169 0.7394
Echinococcus granulosus EG95 0.0081 0.1741 0.1989
Brugia malayi Protein-tyrosine phosphatase 0.0081 0.1741 0.1658
Schistosoma mansoni cpg binding protein 0.0035 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Echinococcus multilocularis tyrosine kinase 0.0041 0.0341 0.0389
Loa Loa (eye worm) hypothetical protein 0.0133 0.3628 0.3564
Brugia malayi Plexin repeat family protein 0.0038 0.0205 0.0108
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0053 0.074 0.0846
Brugia malayi Prion-like- 0.0053 0.0747 0.0655
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0083 0.1818 0.2077
Echinococcus multilocularis roundabout 2 0.014 0.3864 0.4414
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0989 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0989 0.1129
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Schistosoma mansoni factor for adipocyte differentiation 0.0081 0.1741 0.2086
Echinococcus multilocularis tyrosine protein kinase HCK 0.0063 0.112 0.128
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.3697 0.4431
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Onchocerca volvulus 0.0041 0.0341 0.0398
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0459 0.0524
Schistosoma mansoni cell adhesion molecule 0.014 0.3864 0.4631
Echinococcus multilocularis down syndrome cell adhesion 0.0053 0.0747 0.0854
Echinococcus granulosus roundabout 2 0.014 0.3864 0.4414
Onchocerca volvulus Tyrosine kinase homolog 0.0083 0.1818 0.2832
Schistosoma mansoni tyrosine kinase 0.0067 0.1247 0.1494
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0086 0.193 0.2204
Loa Loa (eye worm) hypothetical protein 0.018 0.5304 0.5257
Brugia malayi protein-tyrosine kinase 0.0075 0.153 0.1445
Brugia malayi Tyrosine-protein kinase abl-1 0.0143 0.3957 0.3897
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0081 0.1741 0.1989
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.3628 0.3564
Brugia malayi plexin A 0.0045 0.0452 0.0356
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0747 0.0655
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.193 0.2204
Echinococcus granulosus tyrosine protein kinase Blk 0.0075 0.153 0.1748
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0086 0.193 0.2204
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.1741 0.1658
Schistosoma mansoni tyrosine kinase 0.0067 0.1247 0.1494
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0059 0.0983 0.0893
Echinococcus multilocularis insulin growth factor binding 0.0053 0.0747 0.0854
Loa Loa (eye worm) hypothetical protein 0.014 0.3864 0.3803
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0341 0.0244
Echinococcus multilocularis cell adhesion molecule 0.0081 0.1741 0.1989
Schistosoma mansoni titin 0.0081 0.1741 0.2086
Brugia malayi Protein kinase domain containing protein 0.0041 0.0341 0.0244
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0747 0.0655
Echinococcus multilocularis titin 0.0053 0.0747 0.0854
Loa Loa (eye worm) hypothetical protein 0.0035 0.0125 0.0026
Schistosoma mansoni tripartite motif protein trim9 0.0081 0.1741 0.2086
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 1 1
Schistosoma mansoni cell adhesion molecule 0.0059 0.0983 0.1179
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0081 0.1741 0.2086
Brugia malayi Prion-like- 0.0053 0.0747 0.0655
Echinococcus multilocularis protein kinase shaggy 0.0056 0.087 0.0994
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.087 0.0779
Onchocerca volvulus 0.0056 0.087 0.1271
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0086 0.193 0.2204
Loa Loa (eye worm) TK/ABL protein kinase 0.0277 0.8754 0.8741
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0086 0.193 0.2204
Brugia malayi Disorganized muscle protein 1 0.0053 0.0747 0.0655
Echinococcus multilocularis titin 0.0053 0.0747 0.0854
Loa Loa (eye worm) disorganized muscle protein 1 0.0053 0.0747 0.0655
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.101 0.0921
Loa Loa (eye worm) TK protein kinase 0.0083 0.1818 0.1737
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0747 0.0655
Schistosoma mansoni tyrosine kinase 0.0097 0.2318 0.2778
Schistosoma mansoni septate junction protein 0.0059 0.0983 0.1179
Brugia malayi Leucine Rich Repeat family protein 0.0053 0.0747 0.0655
Schistosoma mansoni cell adhesion molecule 0.014 0.3864 0.4631
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Brugia malayi hypothetical protein 0.0041 0.0341 0.0244
Schistosoma mansoni tyrosine kinase 0.0178 0.5229 0.6267
Loa Loa (eye worm) hypothetical protein 0.0053 0.0747 0.0655
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6169 0.5804
Onchocerca volvulus 0.0081 0.1741 0.2705
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0086 0.193 0.2204
Loa Loa (eye worm) hypothetical protein 0.0081 0.1741 0.1658
Loa Loa (eye worm) plexin A 0.0045 0.0452 0.0356
Echinococcus multilocularis Netrin receptor DCC 0.0081 0.1741 0.1989
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.6169 1
Brugia malayi Fibronectin type III domain containing protein 0.0101 0.2466 0.239
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0989 0.5679
Brugia malayi Immunoglobulin I-set domain containing protein 0.0101 0.2466 0.239
Schistosoma mansoni nephrin 0.014 0.3864 0.4631
Schistosoma mansoni titin 0.0053 0.0747 0.0895
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0989 0.013
Schistosoma mansoni hypothetical protein 0.0205 0.6169 0.7394
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0133 0.3628 0.3564
Echinococcus multilocularis twitchin 0.0055 0.0816 0.0932
Echinococcus multilocularis contactin neuroglian septate junction protein 0.014 0.3864 0.4414
Brugia malayi SH2 domain containing protein 0.0041 0.0341 0.0244
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0053 0.0747 0.0854
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0081 0.1741 1
Brugia malayi Peroxidasin 0.0059 0.0983 0.0893
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.0983 0.0893
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0747 0.0655
Entamoeba histolytica protein kinase, putative 0.0056 0.087 0.7767
Schistosoma mansoni tyrosine kinase 0.0178 0.5229 0.6267
Echinococcus granulosus titin 0.0053 0.0747 0.0854
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0059 0.0983 0.1123
Echinococcus granulosus protein kinase shaggy 0.0056 0.087 0.0994
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.087 0.7209
Echinococcus multilocularis tyrosine protein kinase Srms 0.0075 0.153 0.1748
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0816 0.0978
Echinococcus multilocularis usherin 0.0081 0.1741 0.1989
Echinococcus granulosus Netrin receptor DCC 0.0081 0.1741 0.1989

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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