Detailed information for compound 1446006

Basic information

Technical information
  • TDR Targets ID: 1446006
  • Name: N-[2-[4-(2-fluorophenyl)piperazin-1-yl]sulfon ylethyl]-2-(4-phenylphenyl)acetamide
  • MW: 481.582 | Formula: C26H28FN3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)c1ccccc1)NCCS(=O)(=O)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C26H28FN3O3S/c27-24-8-4-5-9-25(24)29-15-17-30(18-16-29)34(32,33)19-14-28-26(31)20-21-10-12-23(13-11-21)22-6-2-1-3-7-22/h1-13H,14-20H2,(H,28,31)
  • InChiKey: PWQIJLCYQBDIBR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-[[4-(2-fluorophenyl)-1-piperazinyl]sulfonyl]ethyl]-2-(4-phenylphenyl)acetamide
  • N-[2-[4-(2-fluorophenyl)piperazin-1-yl]sulfonylethyl]-2-(4-phenylphenyl)ethanamide
  • NCGC00133028-01
  • G678-0201

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis roundabout 2 0.0143 0.5498 0.542
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Echinococcus granulosus neuroglian 0.007 0.2016 0.1877
Schistosoma mansoni hypothetical protein 0.0064 0.1704 0.1618
Brugia malayi SPRY domain containing protein 0.0064 0.1704 0.1908
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.068 0.068
Echinococcus granulosus c4b binding protein beta chain 0.0047 0.0887 0.0728
Echinococcus multilocularis titin 0.0042 0.068 0.0517
Echinococcus granulosus anosmin 1 0.0064 0.1704 0.1559
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2254
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1086 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1086 0.1086
Brugia malayi Immunoglobulin I-set domain containing protein 0.02 0.8203 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0622 0.0561
Loa Loa (eye worm) hypothetical protein 0.0104 0.3612 0.3612
Echinococcus multilocularis twitchin 0.0043 0.0702 0.054
Brugia malayi Plexin repeat family protein 0.0035 0.0316 0.018
Onchocerca volvulus 0.0064 0.1704 0.185
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0064 0.1704 0.1559
Brugia malayi Myb-like DNA-binding domain containing protein 0.0042 0.068 0.0633
Echinococcus granulosus lamin dm0 0.0033 0.0212 0.0041
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0064 0.1704 0.4949
Schistosoma mansoni tyrosine kinase 0.0038 0.0481 0.0333
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Loa Loa (eye worm) hypothetical protein 0.0115 0.4162 0.4162
Echinococcus granulosus titin 0.0042 0.068 0.0517
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.4162 0.4968
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0042 0.0686 0.0523
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0064 0.1704 0.1559
Echinococcus multilocularis Netrin receptor DCC 0.0064 0.1704 0.1559
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0481 0.0315
Echinococcus granulosus G1Y162 protein 0.0064 0.1704 0.1559
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Schistosoma mansoni titin 0.0042 0.068 0.0542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Echinococcus multilocularis anosmin 1 0.0064 0.1704 0.1559
Echinococcus multilocularis 0.0046 0.0857 0.0698
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) RNA binding protein 0.0076 0.2309 0.2309
Onchocerca volvulus 0.0064 0.1704 0.185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Loa Loa (eye worm) TK protein kinase 0.0067 0.1877 0.1877
Brugia malayi Prion-like- 0.0042 0.068 0.0633
Onchocerca volvulus 0.0042 0.068 0.0614
Schistosoma mansoni titin 0.0042 0.068 0.0542
Plasmodium vivax apical sushi protein, putative 0.0047 0.0887 0.5
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Echinococcus multilocularis anosmin 1 0.0064 0.1704 0.1559
Schistosoma mansoni titin 0.0042 0.068 0.0542
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0481 0.0315
Echinococcus granulosus titin 0.0107 0.3748 0.3639
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Brugia malayi Peroxidasin 0.0052 0.1121 0.1183
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2254
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Brugia malayi plexin A 0.0041 0.062 0.0558
Echinococcus granulosus fibronectin type III domain-containing protein 0.0064 0.1704 0.1559
Brugia malayi Fibronectin type III domain containing protein 0.0092 0.304 0.3572
Echinococcus granulosus EG95 0.0064 0.1704 0.1559
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1531 0.1531
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.1116 0.1116
Schistosoma mansoni factor for adipocyte differentiation 0.0064 0.1704 0.1618
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1086 0.093
Schistosoma mansoni neuroglian 0.0115 0.4162 0.42
Schistosoma mansoni cell adhesion molecule 0.0101 0.3476 0.348
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Schistosoma mansoni lamin 0.0033 0.0212 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.304 0.3572
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0686 0.064
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0042 0.068 0.0517
Onchocerca volvulus 0.0047 0.0887 0.0864
Schistosoma mansoni protein tyrosine phosphatase 0.0064 0.1704 0.1618
Schistosoma mansoni nephrin related 0.0042 0.068 0.0542
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2309 0.2175
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2309 0.2309
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0064 0.1704 0.1618
Onchocerca volvulus 0.0047 0.0887 0.0864
Leishmania major cathepsin L-like protease 0.0077 0.2335 1
Echinococcus multilocularis transfer RNA-Phe 0.0106 0.3726 0.3617
Schistosoma mansoni nephrin 0.0115 0.4162 0.42
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.4162 0.4968
Echinococcus multilocularis epidermal growth factor receptor 0.0104 0.3632 0.3521
Schistosoma mansoni titin 0.0051 0.1116 0.1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2254
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0115 0.4162 0.406
Echinococcus granulosus roundabout 2 0.0143 0.5498 0.542
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0107 0.3748 0.3748
Onchocerca volvulus 0.0042 0.068 0.0614
Onchocerca volvulus 0.0033 0.0212 0.0049
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0051 0.1116 0.114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0104 0.3632 0.3521
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0064 0.1704 0.1559
Schistosoma mansoni tyrosine kinase 0.0104 0.3632 0.3644
Brugia malayi Animal haem peroxidase family protein 0.0042 0.068 0.0633
Onchocerca volvulus 0.0042 0.068 0.0614
Schistosoma mansoni tyrosine kinase 0.0038 0.0481 0.0333
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1531 0.1693
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0038 0.0481 0.0333
Onchocerca volvulus 0.0064 0.1704 0.185
Schistosoma mansoni hypothetical protein 0.0041 0.0622 0.0481
Schistosoma mansoni titin 0.0064 0.1704 0.1618
Echinococcus granulosus C type lectin domian containing protein 0.0047 0.0887 0.0728
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0064 0.1704 0.1618
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2335 1
Onchocerca volvulus 0.0047 0.0887 0.0864
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0042 0.068 0.0633
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0073 0.214 0.2002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Onchocerca volvulus 0.0047 0.0887 0.0864
Schistosoma mansoni tyrosine kinase 0.0077 0.2312 0.2257
Echinococcus granulosus hemicentin 1 0.0051 0.1116 0.0961
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0064 0.1704 0.1618
Leishmania major hypothetical protein, conserved 0.0064 0.1704 0.4949
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0042 0.068 0.0517
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0064 0.1704 0.1559
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Echinococcus granulosus cell adhesion molecule 0.0064 0.1704 0.1559
Echinococcus granulosus Fibronectin type III 0.0064 0.1704 0.1559
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Brugia malayi SRC-1 0.0038 0.0481 0.0385
Echinococcus multilocularis neuroglian 0.007 0.2016 0.1877
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0106 0.3726 0.3726
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0481 0.0315
Schistosoma mansoni septate junction protein 0.0051 0.1116 0.1
Schistosoma mansoni cell adhesion molecule 0.0115 0.4162 0.42
Brugia malayi Prion-like- 0.0051 0.1116 0.1176
Echinococcus multilocularis roundabout 2 0.0115 0.4162 0.406
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1086 0.093
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1548 0.37
Onchocerca volvulus 0.0106 0.3726 0.4292
Echinococcus multilocularis Netrin receptor DCC 0.0064 0.1704 0.1559
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0136 0.5131 0.5046
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Brugia malayi Lethal protein 805 0.0064 0.1704 0.1908
Echinococcus granulosus peroxidasin 0.0052 0.1121 0.0966
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus granulosus epidermal growth factor receptor 0.0104 0.3632 0.3521
Schistosoma mansoni tyrosine kinase 0.0038 0.0481 0.0333
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Echinococcus multilocularis Fibronectin, type III 0.0064 0.1704 0.1559
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0064 0.1704 0.1908
Loa Loa (eye worm) hypothetical protein 0.0092 0.304 0.304
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0481 0.0315
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Echinococcus granulosus Netrin receptor DCC 0.0064 0.1704 0.1559
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0067 0.1877 0.1735
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0064 0.1704 0.4949
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0051 0.1116 0.1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Schistosoma mansoni titin 0.0106 0.3726 0.3742
Onchocerca volvulus Netrin receptor homolog 0.0042 0.068 0.0614
Loa Loa (eye worm) myotactin form A 0.0064 0.1704 0.1704
Brugia malayi myotactin form B 0.0064 0.1704 0.1908
Echinococcus multilocularis lamin 0.0033 0.0212 0.0041
Echinococcus multilocularis plexin a4 0.0041 0.062 0.0456
Loa Loa (eye worm) hypothetical protein 0.0033 0.0212 0.0212
Brugia malayi Disorganized muscle protein 1 0.0042 0.068 0.0633
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Schistosoma mansoni cell adhesion molecule 0.0106 0.3726 0.3742
Echinococcus granulosus leucine rich repeat containing protein 4 0.0042 0.068 0.0517
Echinococcus multilocularis titin 0.0107 0.3748 0.3639
Echinococcus multilocularis usherin 0.0064 0.1704 0.1559
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1086 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0067 0.1877 0.1735
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0115 0.4162 0.406
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Onchocerca volvulus 0.0107 0.3748 0.4319
Loa Loa (eye worm) disorganized muscle protein 1 0.0042 0.068 0.068
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0064 0.1704 0.1618
Echinococcus multilocularis hemicentin 1 0.0051 0.1116 0.0961
Onchocerca volvulus 0.0042 0.0686 0.0621
Echinococcus granulosus tar DNA binding protein 0.0076 0.2309 0.2175
Schistosoma mansoni c4b-binding protein beta chain 0.0047 0.0887 0.0759
Schistosoma mansoni myosin-binding protein-related 0.0106 0.3726 0.3742
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0481 0.0315
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) TK protein kinase 0.0032 0.0171 0.0171
Loa Loa (eye worm) plexin A 0.0041 0.062 0.062
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0115 0.4162 0.406
Echinococcus granulosus intermediate filament protein 0.0033 0.0212 0.0041
Echinococcus granulosus plexin a4 0.0041 0.062 0.0456
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0481 0.0315
Schistosoma mansoni hypothetical protein 0.0064 0.1704 0.1618
Onchocerca volvulus Tyrosine kinase homolog 0.0205 0.8453 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.02 0.8203 0.8203
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0042 0.068 0.0517
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Loa Loa (eye worm) TK/INSR protein kinase 0.0072 0.2085 0.2085
Echinococcus multilocularis titin 0.0042 0.068 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0702 0.0565
Echinococcus multilocularis epidermal growth factor receptor 0.0173 0.6921 0.6867
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0073 0.214 0.214
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0481 0.0315
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Plasmodium falciparum apical sushi protein 0.0047 0.0887 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0503 0.0337
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0115 0.4162 0.406
Echinococcus multilocularis down syndrome cell adhesion 0.0042 0.068 0.0517
Echinococcus granulosus titin 0.0042 0.068 0.0517
Onchocerca volvulus 0.0047 0.0887 0.0864
Onchocerca volvulus Peroxidasin homolog 0.0042 0.0686 0.0621
Onchocerca volvulus 0.0042 0.068 0.0614
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.068 0.068
Echinococcus granulosus anosmin 1 0.0064 0.1704 0.1559
Echinococcus multilocularis cell adhesion molecule 0.0064 0.1704 0.1559
Echinococcus granulosus contactin 0.0115 0.4162 0.406
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0064 0.1704 0.1559
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2016 0.7446
Onchocerca volvulus 0.0064 0.1704 0.185
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0064 0.1704 0.1704
Schistosoma mansoni septate junction protein 0.0051 0.1116 0.1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Echinococcus granulosus roundabout 2 0.0115 0.4162 0.406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0106 0.3726 0.3726
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0481 0.0315
Echinococcus multilocularis tyrosine protein kinase Abl 0.0117 0.4239 0.4138
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2335 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1086 1
Schistosoma mansoni hypothetical protein 0.0106 0.3726 0.3742
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Onchocerca volvulus 0.0042 0.068 0.0614
Loa Loa (eye worm) hypothetical protein 0.0052 0.1137 0.1137
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.068 0.068
Schistosoma mansoni tyrosine kinase 0.0231 0.9683 1
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.1704 0.1908
Loa Loa (eye worm) one IG domain family member 0.0042 0.068 0.068
Echinococcus multilocularis neuroglian 0.0115 0.4162 0.406
Echinococcus multilocularis tyrosine protein kinase otk 0.0051 0.1116 0.0961
Onchocerca volvulus 0.0042 0.068 0.0614
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Schistosoma mansoni roundabout 0.0051 0.1116 0.1
Echinococcus granulosus tyrosine protein kinase otk 0.0051 0.1116 0.0961
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1086 0.093
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0115 0.4162 0.42
Brugia malayi Leucine Rich Repeat family protein 0.0042 0.0686 0.064
Brugia malayi protein unc-22 0.0107 0.3748 0.4453
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1086 0.0969
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0047 0.0887 0.0887
Echinococcus granulosus titin 0.0042 0.068 0.0517
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1704 0.4949
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Onchocerca volvulus 0.0064 0.1704 0.185
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0042 0.068 0.0517
Schistosoma mansoni ephrin receptor 0.0089 0.2901 0.2875
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Onchocerca volvulus 0.0064 0.1704 0.185
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Schistosoma mansoni tyrosine kinase 0.0079 0.2436 0.2387
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0037 0.043 0.043
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Brugia malayi Prion-like- 0.0042 0.068 0.0633
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0481 0.0315
Echinococcus multilocularis c4b binding protein beta chain 0.0047 0.0887 0.0728
Echinococcus granulosus down syndrome cell adhesion 0.0042 0.068 0.0517
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.043 0.0263
Schistosoma mansoni cell adhesion molecule 0.0106 0.3726 0.3742
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0042 0.068 0.0542
Onchocerca volvulus 0.0035 0.0316 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Schistosoma mansoni slit 0.0042 0.0686 0.0548
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Schistosoma mansoni tyrosine kinase 0.0032 0.0171 0.0008
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0106 0.3726 0.3726
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.1704 0.1908
Loa Loa (eye worm) CAMK protein kinase 0.0107 0.3748 0.3748
Onchocerca volvulus 0.0047 0.0887 0.0864
Loa Loa (eye worm) animal heme peroxidase 0.0042 0.068 0.068
Echinococcus multilocularis C type lectin domian containing protein 0.0047 0.0887 0.0728
Schistosoma mansoni tyrosine kinase 0.0173 0.6921 0.7098
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Echinococcus granulosus roundabout 2 0.0115 0.4162 0.406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.2452 0.2452
Loa Loa (eye worm) UNCoordinated family member 0.0064 0.1704 0.1704
Loa Loa (eye worm) hypothetical protein 0.0032 0.0184 0.0184
Brugia malayi hypothetical protein 0.0092 0.304 0.3572
Brugia malayi TAR-binding protein 0.0076 0.2309 0.2661
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1086 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Onchocerca volvulus 0.0138 0.5234 0.6113
Echinococcus multilocularis titin 0.0042 0.068 0.0517
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0064 0.1704 0.1559
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0064 0.1704 0.1559
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Onchocerca volvulus 0.0047 0.0887 0.0864
Loa Loa (eye worm) TK/EGFR protein kinase 0.0173 0.6921 0.6921
Echinococcus multilocularis insulin growth factor binding 0.0042 0.068 0.0517
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Schistosoma mansoni tyrosine kinase 0.0079 0.2436 0.2387
Schistosoma mansoni tripartite motif protein trim9 0.0064 0.1704 0.1618
Brugia malayi Prion-like- 0.0042 0.068 0.0633
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.1704 0.1908
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Schistosoma mansoni intermediate filament proteins 0.0033 0.0212 0.0051
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0064 0.1704 0.1704
Onchocerca volvulus 0.0106 0.3726 0.4292
Loa Loa (eye worm) TK/ABL protein kinase 0.0238 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.3748 0.4453
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.1116 0.1116
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0032 0.0171 1
Echinococcus multilocularis lachesin 0.0051 0.1116 0.0961
Echinococcus granulosus nephrin 0.0106 0.3726 0.3617
Loa Loa (eye worm) hypothetical protein 0.0106 0.3726 0.3726
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0051 0.1116 0.0961
Echinococcus granulosus Netrin receptor DCC 0.0064 0.1704 0.1559
Brugia malayi GCC2 and GCC3 family protein 0.0047 0.0887 0.089
Schistosoma mansoni titin 0.0042 0.068 0.0542
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2309 0.2661
Echinococcus granulosus insulin receptor 0.0072 0.2085 0.1947
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2335 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0622 0.0622
Echinococcus granulosus twitchin 0.0071 0.2038 0.19
Onchocerca volvulus 0.0047 0.0887 0.0864
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0136 0.5131 0.5046
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0481 0.0315
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1086 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.3748 0.3765
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2335 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.4728 0.5673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2309 0.2309
Loa Loa (eye worm) projectin 0.0106 0.3726 0.3726
Echinococcus multilocularis lamin dm0 0.0033 0.0212 0.0041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Onchocerca volvulus 0.0064 0.1704 0.185
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Brugia malayi MAP kinase sur-1 0.0051 0.1086 0.1138
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.1704 0.1908
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Loa Loa (eye worm) hypothetical protein 0.006 0.1531 0.1531
Schistosoma mansoni tyrosine kinase 0.0038 0.0481 0.0333
Echinococcus granulosus Fibronectin type III domain containing protein 0.0064 0.1704 0.1559
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0116 0.4184 0.4184
Schistosoma mansoni hemicentin 0.0106 0.3726 0.3742
Brugia malayi intermediate filament protein 0.0033 0.0212 0.0051
Onchocerca volvulus 0.0042 0.068 0.0614
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0064 0.1704 0.1559
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Schistosoma mansoni tyrosine kinase 0.0079 0.2436 0.2387
Brugia malayi Protein-tyrosine phosphatase 0.0064 0.1704 0.1908
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1531 0.1693
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Schistosoma mansoni factor for adipocyte differentiation 0.0064 0.1704 0.1618
Loa Loa (eye worm) hypothetical protein 0.0106 0.3726 0.3726
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Echinococcus multilocularis roundabout 2 0.0115 0.4162 0.406
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0106 0.3726 0.3617
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.1877 0.2123
Schistosoma mansoni plexin 0.0035 0.0316 0.016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0316 0.0316
Onchocerca volvulus 0.0033 0.0212 0.0049
Echinococcus multilocularis musashi 0.0033 0.0212 0.0041
Schistosoma mansoni factor for adipocyte differentiation 0.0064 0.1704 0.1618
Brugia malayi kettin 0.0042 0.068 0.0633
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Loa Loa (eye worm) SRC-1 0.0038 0.0481 0.0481
Echinococcus granulosus anosmin 1 0.0064 0.1704 0.1559
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Brugia malayi pregnancy-associated plasma protein-A 0.0047 0.0887 0.089
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.068 0.068
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Schistosoma mansoni cell adhesion molecule 0.0042 0.068 0.0542
Echinococcus multilocularis insulin receptor 0.0072 0.2085 0.1947
Schistosoma mansoni cell adhesion molecule 0.0115 0.4162 0.42
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0481 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0117 0.4239 0.5064
Brugia malayi hypothetical protein 0.0047 0.0887 0.089
Echinococcus multilocularis titin 0.0064 0.1704 0.1559
Echinococcus multilocularis hemicentin 1 0.0051 0.1116 0.0961
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0115 0.4162 0.406
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0064 0.1704 0.4949
Brugia malayi Lethal protein 805 0.0064 0.1704 0.1908
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.1116 0.1176
Onchocerca volvulus 0.0064 0.1704 0.185
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2309 0.2254
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0064 0.1704 0.1559
Schistosoma mansoni titin 0.0042 0.068 0.0542
Schistosoma mansoni tyrosine kinase 0.0104 0.3632 0.3644
Echinococcus granulosus insulin growth factor binding 0.0042 0.068 0.0517
Loa Loa (eye worm) hypothetical protein 0.0092 0.304 0.304
Schistosoma mansoni nephrin 0.0134 0.5063 0.5146
Brugia malayi Furin-like cysteine rich region family protein 0.0173 0.6921 0.8403
Loa Loa (eye worm) hypothetical protein 0.0079 0.2452 0.2452
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0064 0.1704 0.1559
Leishmania major cathepsin L-like protease 0.0077 0.2335 1
Echinococcus granulosus c src tyrosine kinase 0.0038 0.0481 0.0315
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0038 0.0481 0.0315
Loa Loa (eye worm) lethal protein 805 0.0064 0.1704 0.1704
Onchocerca volvulus 0.0047 0.0887 0.0864
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0064 0.1704 0.1704
Echinococcus multilocularis anosmin 1 0.0064 0.1704 0.1559
Echinococcus multilocularis peroxidasin 0.0052 0.1121 0.0966
Schistosoma mansoni tyrosine kinase 0.0032 0.0171 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.068 0.0633
Schistosoma mansoni tyrosine kinase 0.0072 0.2085 0.2018
Loa Loa (eye worm) TK/ROR protein kinase 0.0067 0.1877 0.1877
Onchocerca volvulus 0.0064 0.1704 0.185
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Brugia malayi Protein kinase domain containing protein 0.0072 0.2085 0.2382
Echinococcus granulosus neuroglian 0.0115 0.4162 0.406
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0212 0.0051
Leishmania major cathepsin L-like protease 0.0077 0.2335 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1121 0.1121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1086 0.093
Brugia malayi Fibronectin type III domain containing protein 0.0064 0.1704 0.1908
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.0686 0.0686
Echinococcus granulosus titin 0.0107 0.3748 0.3639
Onchocerca volvulus Peroxidasin homolog 0.0042 0.068 0.0614
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0073 0.214 0.2002
Loa Loa (eye worm) hypothetical protein 0.0042 0.068 0.068
Echinococcus granulosus usherin 0.0064 0.1704 0.1559
Brugia malayi RNA binding protein 0.0076 0.2309 0.2661
Onchocerca volvulus 0.0064 0.1704 0.185
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0042 0.0686 0.0523
Echinococcus granulosus lamin 0.0033 0.0212 0.0041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.3726 0.4426
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0238 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1704 0.1704
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0064 0.1704 0.1908
Schistosoma mansoni titin 0.0107 0.3748 0.3765
Schistosoma mansoni hypothetical protein 0.0042 0.068 0.0542
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Onchocerca volvulus 0.0047 0.0887 0.0864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0115 0.4162 0.4162
Loa Loa (eye worm) hypothetical protein 0.0047 0.0887 0.0887
Schistosoma mansoni tyrosine kinase 0.0072 0.2085 0.2018
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1086 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.1116 0.1116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0481 0.0315
Loa Loa (eye worm) hypothetical protein 0.0092 0.304 0.304
Brugia malayi myotactin form A 0.0064 0.1704 0.1908
Onchocerca volvulus Putative titin 0.0042 0.068 0.0614
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.4162 0.4968
Echinococcus granulosus epidermal growth factor receptor 0.0173 0.6921 0.6867
Schistosoma mansoni cell adhesion molecule 0.0051 0.1116 0.1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2335 1
Onchocerca volvulus 0.0064 0.1704 0.185
Loa Loa (eye worm) TK/FER protein kinase 0.0032 0.0171 0.0171
Brugia malayi Sushi domain 0.0047 0.0887 0.089
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0064 0.1704 0.1908
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0064 0.1704 0.1704
Echinococcus granulosus lachesin 0.0051 0.1116 0.0961
Brugia malayi hypothetical protein 0.0064 0.1704 0.1908
Echinococcus multilocularis 0.0042 0.068 0.0517
Schistosoma mansoni lamin 0.0033 0.0212 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.214 0.245
Echinococcus multilocularis c src tyrosine kinase 0.0038 0.0481 0.0315

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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