Detailed information for compound 144855

Basic information

Technical information
  • TDR Targets ID: 144855
  • Name: S-[2-[(1-methylcyclohexanecarbonyl)amino]phen yl] 2,2-dimethylpropanethioate
  • MW: 333.488 | Formula: C19H27NO2S
  • H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)(C)C)Sc1ccccc1NC(=O)C1(C)CCCCC1
  • InChi: 1S/C19H27NO2S/c1-18(2,3)17(22)23-15-11-7-6-10-14(15)20-16(21)19(4)12-8-5-9-13-19/h6-7,10-11H,5,8-9,12-13H2,1-4H3,(H,20,21)
  • InChiKey: WBCRBXAFIQXPJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-dimethylpropanethioic acid S-[2-[[(1-methylcyclohexyl)-oxomethyl]amino]phenyl] ester
  • S-[2-[(1-methylcyclohexyl)carbonylamino]phenyl] 2,2-dimethylpropanethioate
  • 2,2-dimethylpropanethioic acid S-[2-[(1-methylcyclohexanecarbonyl)amino]phenyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 6 0.0035 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0102 0.0176 0.0176
Plasmodium falciparum importin beta, putative 0.0029 0.0014 0.053
Schistosoma mansoni neuropeptide receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis serotonin receptor 0.0042 0.0042 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0014 0.0415
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.4483 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0057 0.0057
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0042 0.0338
Plasmodium vivax SET domain protein, putative 0.0029 0.0013 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0515 0.0515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0033 0.3542
Onchocerca volvulus 0.0041 0.0039 0.0316
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis CDC7 cell division cycle 7 0.0572 0.123 0.123
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.0038 0.0038
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0081 0.2235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0013 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0033 0.0576
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0042 0.0042
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.0038 0.0038
Echinococcus multilocularis somatostatin receptor 0.0042 0.0042 0.0042
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0056 0.0075 0.9123
Onchocerca volvulus 0.0572 0.123 1
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0075 0.1852
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0038 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0125 0.0229 0.6333
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0053 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi RE15519p 0.0042 0.0042 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0042 0.0042
Echinococcus granulosus mothers against decapentaplegic 2 0.0035 0.0025 0.0025
Brugia malayi Dopamine receptor 0.0042 0.0042 0.0042
Brugia malayi Melatonin receptor type 1A 0.0042 0.0042 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0042 0.0042
Trypanosoma brucei cytochrome P450, putative 0.0037 0.003 0.0573
Brugia malayi Pre-SET motif family protein 0.0029 0.0013 0.0013
Schistosoma mansoni smad1 5 8 and 0.0077 0.0121 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0572 0.123 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Onchocerca volvulus 0.0042 0.0042 0.0338
Schistosoma mansoni hypothetical protein 0.0102 0.0176 0.0176
Trypanosoma cruzi serine/threonine protein kinase, putative 0.004 0.0038 0.1025
Leishmania major DNA damage repair protein, putative 0.0056 0.0075 0.2061
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0042 0.0042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3446 0.7675 0.7675
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.0356 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0042 0.0042
Echinococcus granulosus GPCR family 2 0.0102 0.0176 0.0176
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis smad 0.0077 0.0121 0.0121
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0027 0.0027
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0057 0.0057
Echinococcus granulosus Smad4 0.0077 0.0121 0.0121
Onchocerca volvulus 0.0042 0.0042 0.0338
Onchocerca volvulus 0.0047 0.0053 0.0432
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.0038 0.0038
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0033 0.0033
Onchocerca volvulus 0.0042 0.0042 0.0338
Echinococcus granulosus hypothetical protein 0.0042 0.0042 0.0042
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0033 0.0576
Brugia malayi Dopamine receptor protein 2 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis GPCR, family 2 0.0102 0.0176 0.0176
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.2856 0.6351 0.6351
Schistosoma mansoni histamine h1 receptor 0.0042 0.0042 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0033 0.0656
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni smad 0.0035 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.0356 1
Echinococcus granulosus g protein coupled receptor 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0081 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0033 0.0896
Brugia malayi neuropeptide F receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0033 0.0258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0042 0.0042
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0033 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.003 0.003
Brugia malayi ORL1-like opioid receptor 0.0042 0.0042 0.0042
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0042 0.0042
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine receptor 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0314 0.0653 0.0653
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus multilocularis cyclin dependent kinase 9 0.0172 0.0334 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0356 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0396 0.0396
Onchocerca volvulus 0.0231 0.0466 0.3783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0056 0.0075 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0515 0.0515
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0042 0.0042
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0014 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0072 0.0072
Brugia malayi G-protein coupled receptor 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0075 0.1852
Loa Loa (eye worm) cytochrome P450 0.0029 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Onchocerca volvulus 0.0042 0.0042 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi MH1 domain containing protein 0.0043 0.0044 0.0044
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0042 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0042 0.0042
Echinococcus granulosus neuropeptide receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) MBCTL1 0.0055 0.0072 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0041 0.0039 0.0316
Brugia malayi Protein kinase domain containing protein 0.004 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Brugia malayi Cytochrome P450 family protein 0.0037 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0042 0.0042 0.0042
Mycobacterium leprae putative cytochrome p450 0.0029 0.0014 0.5
Echinococcus granulosus allatostatin A receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.0653 0.0653
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni DNA polymerase IV / kappa 0.0056 0.0075 0.0075
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0042 0.0042
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni kinase 0.0149 0.0282 0.0282
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0013 0.0013
Echinococcus multilocularis cyclin dependent kinase 9 0.0149 0.0282 0.0282
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0042 0.0042
Brugia malayi Importin beta-1 subunit 0.0029 0.0014 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.1134 0.2491 0.2491
Echinococcus granulosus serotonin receptor 0.0042 0.0042 0.0042
Brugia malayi G protein-coupled receptor 0.0042 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0047 0.0053 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0102 0.0176 0.0176
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0081 0.1962
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0014 0.0339
Onchocerca volvulus 0.0041 0.0039 0.0316
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0042 0.0042 0.0042
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.004 0.0038 0.1025
Mycobacterium ulcerans DNA polymerase IV 0.0182 0.0356 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.4483 1 1
Schistosoma mansoni neuropeptide receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trypanosoma brucei unspecified product 0.0182 0.0356 1
Echinococcus granulosus mitogen activated protein kinase 15 0.004 0.0038 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.022 0.0441 0.0441
Giardia lamblia DINP protein human, muc B family 0.0182 0.0356 0.2694
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0075 0.1852
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0056 0.0075 0.9123
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0042 0.0042
Echinococcus granulosus g protein coupled receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Leishmania major hypothetical protein, conserved 0.0028 0.0011 0.0257
Brugia malayi cyclin-dependent kinase 9 0.0149 0.0282 0.0282
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0042 0.0042
Brugia malayi mbt repeat family protein 0.0049 0.0057 0.0057
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0042 0.0042
Brugia malayi Protein kinase domain containing protein 0.0572 0.123 0.123
Brugia malayi Cytochrome P450 family protein 0.0091 0.0151 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Leishmania major serine/threonine kinase-like protein, putative 0.004 0.0038 0.1025
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.0515 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0075 0.2061
Loa Loa (eye worm) nuclear factor I 0.0043 0.0044 0.0044
Trypanosoma brucei unspecified product 0.0125 0.0229 0.6333
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0515 0.0515
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0182 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Echinococcus granulosus sex peptide receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0077 0.0121 0.0121
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.004 0.0038 0.4255
Trichomonas vaginalis CMGC family protein kinase 0.0572 0.123 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0044 0.0044
Loa Loa (eye worm) Smad1 0.0077 0.0121 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0081 0.0081
Trypanosoma brucei unspecified product 0.0125 0.0229 0.6333
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0014 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0075 0.1852
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0013 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0182 0.0356 0.0356
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.0356 1
Echinococcus granulosus tar DNA binding protein 0.0253 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0322 0.067 0.067
Echinococcus multilocularis Smad4 0.0077 0.0121 0.0121
Echinococcus granulosus CDC7 cell division cycle 7 0.0572 0.123 0.123
Schistosoma mansoni hypothetical protein 0.0042 0.0042 0.0042
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0048
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0042 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0182 0.0356 0.0356
Echinococcus granulosus cyclin dependent kinase 9 0.0172 0.0334 0.0334
Schistosoma mansoni ap endonuclease 0.0038 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0125 0.0229 0.6333
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0042 0.0042
Schistosoma mansoni importin beta-1 0.0029 0.0014 0.0014
Echinococcus granulosus somatostatin receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0042 0.0042
Trypanosoma cruzi DNA polymerase eta, putative 0.0182 0.0356 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0042 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Brugia malayi hypothetical protein 0.023 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0091 0.0151 0.0151
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0042 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Echinococcus granulosus dna polymerase kappa 0.0182 0.0356 0.0356
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0033 0.0033
Leishmania major DNA polymerase kappa, putative 0.0182 0.0356 1
Brugia malayi MH2 domain containing protein 0.1134 0.2491 0.2491
Loa Loa (eye worm) MH2 domain-containing protein 0.0077 0.0121 0.0121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0042 0.0042
Schistosoma mansoni myosin xvIII 0.0042 0.0042 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0033 0.0033
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0024 0.0002 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0746
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0048 0.0048
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0072 0.0072
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0025 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0035 0.0025 0.0205
Onchocerca volvulus 0.0041 0.0039 0.0316
Brugia malayi sulfakinin receptor protein 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0014 0.0084
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni adenoreceptor 0.0042 0.0042 0.0042
Brugia malayi AKH receptor 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.2856 0.6351 0.6351
Onchocerca volvulus 0.0042 0.0042 0.0338
Mycobacterium ulcerans hypothetical protein 0.0056 0.0075 0.1782
Trypanosoma brucei protein kinase, putative 0.004 0.0038 0.0788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis serotonin receptor 0.0042 0.0042 0.0042
Echinococcus granulosus orexin receptor type 2 0.0042 0.0042 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0042 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi G-protein coupled receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0042 0.0042
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0039
Loa Loa (eye worm) CDC7 protein kinase 0.0572 0.123 0.123
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0042 0.0042
Echinococcus granulosus snurportin 1 0.0314 0.0653 0.0653
Echinococcus multilocularis 0.0029 0.0014 0.0014
Echinococcus multilocularis mothers against decapentaplegic 6 0.0035 0.0025 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0011 0.0257
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0075 0.1852
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.004 0.0038 0.0038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi Cytochrome P450 family protein 0.0029 0.0014 0.0014
Echinococcus multilocularis tar DNA binding protein 0.0253 0.0515 0.0515
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.004 0.0038 0.1025
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0466 0.3777
Onchocerca volvulus 0.0042 0.0042 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Brugia malayi MH1 domain containing protein 0.0077 0.0121 0.0121
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0011
Schistosoma mansoni DNA polymerase eta 0.0182 0.0356 0.0356
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0042 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi ImpB/MucB/SamB family protein 0.0182 0.0356 0.0356
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0746
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0041 0.0039 0.0316
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0042 0.0042
Echinococcus granulosus neuropeptide receptor 0.0042 0.0042 0.0042
Schistosoma mansoni survival motor neuron protein 0.0047 0.0053 0.0053
Brugia malayi cyclin-dependent kinase 7 homolog 0.004 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0403 0.0403
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni hypothetical protein 0.0102 0.0176 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0042 0.0042
Brugia malayi mothers against decapentaplegic homolog 3 0.0035 0.0025 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0102 0.0176 0.0176
Schistosoma mansoni terminal deoxycytidyl transferase 0.0182 0.0356 0.0356
Onchocerca volvulus 0.0041 0.0039 0.0316
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni Smad4 0.0035 0.0025 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0322 0.067 0.067
Schistosoma mansoni serine/threonine kinase 0.004 0.0038 0.0038
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.004 0.0038 0.4255
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0077 0.0121 0.0121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0102 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.022 0.0441 0.0441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0033 0.0896
Loa Loa (eye worm) hypothetical protein 0.022 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0182 0.0356 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0042 0.0042
Trichomonas vaginalis protein kinase atmrk1, putative 0.004 0.0038 0.0295
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0057 0.0057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0013 0.0013
Schistosoma mansoni smad1 5 8 and 0.0077 0.0121 0.0121
Brugia malayi MH1 domain containing protein 0.0043 0.0044 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0011 0.0257
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0072
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0077 0.0121 0.0121
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0572 0.123 1
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.004 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0033 0.0896
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0465 0.0465
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0014 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0081 0.1962
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni Smad4 0.0077 0.0121 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0102 0.0176 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0081 0.1962
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0515 0.0515
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi polk-prov protein 0.0056 0.0075 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.0515 0.0515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.0356 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0042 0.0042
Brugia malayi Pre-SET motif family protein 0.0203 0.0403 0.0403
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.4483 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0042 0.0042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0033 0.3542
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0042 0.0042
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0042 0.0042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0042 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0125 0.0229 0.6333
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0042 0.0042
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0042 0.0042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0182 0.0356 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0033 0.5
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus granulosus serine:threonine protein kinase NLK 0.004 0.0038 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0027 0.0027
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0042 0.0042
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.004 0.0038 0.1025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi MH2 domain containing protein 0.0035 0.0025 0.0025
Entamoeba histolytica cell division protein kinase 2, putative 0.004 0.0038 0.1065
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0081 1
Schistosoma mansoni hypothetical protein 0.0029 0.0014 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.004 0.0038 0.1065
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0176 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0102 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0025 0.0025
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni smad1 5 8 and 0.0077 0.0121 0.0121
Onchocerca volvulus 0.0042 0.0042 0.0338
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi putative neuropeptide receptor 0.0042 0.0042 0.0042
Trypanosoma cruzi DNA polymerase eta, putative 0.0056 0.0075 0.2061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0014 0.0339
Schistosoma mansoni protein kinase 0.004 0.0038 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0075 0.1852
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0322 0.067 0.067
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0042 0.0042
Echinococcus granulosus dna polymerase eta 0.0182 0.0356 0.0356
Onchocerca volvulus 0.0042 0.0042 0.0338
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.004 0.0038 0.0788
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0182 0.0356 0.0356
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0149 0.0282 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0075 0.2061
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.0356 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.1134 0.2491 0.2491
Echinococcus granulosus g protein coupled receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0057 0.0057
Brugia malayi TAR-binding protein 0.0253 0.0515 0.0515
Brugia malayi RNA binding protein 0.0253 0.0515 0.0515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0304 0.0629 0.0629
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0057 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0056 0.0075 0.9123
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Brugia malayi MH1 domain containing protein 0.0077 0.0121 0.0121
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0039 0.0039
Brugia malayi Smad1 0.0077 0.0121 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine receptor 0.0042 0.0042 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0033 0.0258
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0042 0.0042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0322 0.067 0.067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0072 0.0072
Brugia malayi larval opioid receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0057 0.0057
Onchocerca volvulus 0.0029 0.0013 0.0106
Schistosoma mansoni opsin-like receptor 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0182 0.0356 0.2882
Loa Loa (eye worm) haspin protein kinase 0.004 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Schistosoma mansoni ap endonuclease 0.0038 0.0033 0.0033
Schistosoma mansoni biogenic amine receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.023 0.0465 0.0465
Trichomonas vaginalis serine/threonine kinase, putative 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis dna polymerase eta 0.0182 0.0356 0.0356
Brugia malayi Dopamine receptor protein 1 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni cytochrome P450 0.0029 0.0014 0.0014
Onchocerca volvulus 0.0041 0.0039 0.0316
Echinococcus granulosus importin subunit beta 1 0.0029 0.0014 0.0014
Plasmodium vivax DNA repair protein REV1, putative 0.0056 0.0075 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Echinococcus granulosus Cell division cycle 2 protein kinase 0.004 0.0038 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0027 0.0027
Trypanosoma brucei DNA polymerase eta, putative 0.0182 0.0356 1
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0746
Brugia malayi GnHR receptor homolog 0.0042 0.0042 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0014 0.0484
Schistosoma mansoni hypothetical protein 0.0102 0.0176 0.0176
Echinococcus granulosus cyclin dependent kinase 9 0.0149 0.0282 0.0282
Brugia malayi neuropeptide F receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0515 0.0515
Echinococcus multilocularis snurportin 1 0.0314 0.0653 0.0653
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Loa Loa (eye worm) TAR-binding protein 0.0253 0.0515 0.0515
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0057 0.0463
Leishmania major DNA polymerase eta, putative 0.0182 0.0356 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.0356 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0077 0.0121 0.0121
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0282 0.0282
Plasmodium vivax importin-beta 2, putative 0.0029 0.0014 0.053
Echinococcus granulosus geminin 0.2856 0.6351 0.6351
Leishmania major cytochrome p450-like protein 0.0029 0.0014 0.0339
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0396 0.0396
Schistosoma mansoni smad 0.0077 0.0121 0.0121
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0042 0.0042
Echinococcus multilocularis mothers against decapentaplegic 2 0.0035 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0746
Leishmania major DNA polymerase kappa, putative 0.0056 0.0075 0.2061
Echinococcus multilocularis mothers against decapentaplegic 5 0.0077 0.0121 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis serine:threonine protein kinase NLK 0.004 0.0038 0.0038
Leishmania major cytochrome p450-like protein 0.0037 0.003 0.0815
Schistosoma mansoni opsin-like receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0042 0.0042
Toxoplasma gondii exonuclease III APE 0.0038 0.0033 0.3231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0013 0.0369
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0014 0.0339
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.004 0.0038 0.0295
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0182 0.0356 1
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0042 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0042 0.0042
Brugia malayi Cell division protein kinase 2 0.004 0.0038 0.0038
Loa Loa (eye worm) RNA binding protein 0.0253 0.0515 0.0515
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.004 0.0038 0.0038
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0042 0.0042
Brugia malayi cytochrome P450 0.0029 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0182 0.0356 0.0356
Loa Loa (eye worm) CYP4Cod1 0.0037 0.003 0.003
Brugia malayi mbt repeat family protein 0.0049 0.0057 0.0057
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0042 0.0042
Leishmania major cytochrome p450-like protein 0.0029 0.0014 0.0339
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0039 0.0039
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0042 0.0042 0.0042
Brugia malayi RNA, U transporter 1 0.0084 0.0136 0.0136
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.003 0.0493
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0042 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.003 0.0815
Leishmania major DNA polymerase eta, putative 0.0056 0.0075 0.2061
Trichomonas vaginalis AGC family protein kinase 0.004 0.0038 0.0295
Mycobacterium ulcerans DNA polymerase IV 0.0182 0.0356 1
Brugia malayi MH2 domain containing protein 0.0077 0.0121 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Schistosoma mansoni neuropeptide receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.4483 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0042 0.0042
Echinococcus granulosus TGF beta signal transducer SmadC 0.0077 0.0121 0.0121
Brugia malayi Cytochrome P450 family protein 0.0037 0.003 0.003
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0042 0.0042
Echinococcus granulosus fmrfamide receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0042 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Giardia lamblia DNA damage repair protein 0.0056 0.0075 0.0345
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0042 0.0042
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0042 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0028 0.0011 0.0011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0057 0.0057
Entamoeba histolytica protein kinase domain containing protein 0.0149 0.0282 0.7931
Brugia malayi Serotonin receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0042 0.0042
Brugia malayi MH2 domain containing protein 0.0077 0.0121 0.0121
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0014 0.0339
Brugia malayi Serotonin receptor 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0033 0.0937
Plasmodium falciparum MO15-related protein kinase 0.004 0.0038 0.4255
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0075 0.2061
Trichomonas vaginalis DNA polymerase eta, putative 0.0182 0.0356 0.2882
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0072 0.0072
Echinococcus multilocularis dna polymerase kappa 0.0182 0.0356 0.0356
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0072 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Entamoeba histolytica deoxycytidyl transferase, putative 0.0182 0.0356 1
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0042 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.003 0.0815
Echinococcus multilocularis geminin 0.2856 0.6351 0.6351
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0038 0.0295
Onchocerca volvulus 0.0041 0.0039 0.0316
Trypanosoma brucei chrX additional, unordered contigs 0.0056 0.0075 0.1852
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0081 0.1962
Brugia malayi Latrophilin receptor protein 2 0.0102 0.0176 0.0176
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0042 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0102 0.0176 0.0176
Echinococcus multilocularis sex peptide receptor 0.0042 0.0042 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0049 0.0057 0.0463
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0042 0.0042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0048 0.0048
Giardia lamblia Kinase, CDC7 0.0572 0.123 1
Schistosoma mansoni Smad4 0.0035 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0042 0.0042
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0039 0.0039
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0081 0.0081
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0042 0.0042
Onchocerca volvulus 0.0042 0.0042 0.0338
Onchocerca volvulus 0.0572 0.123 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Plasmodium falciparum DNA repair protein REV1, putative 0.0056 0.0075 1
Echinococcus granulosus smad 0.0077 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.0356 1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0038 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0075 0.2061
Schistosoma mansoni opsin-like receptor 0.0042 0.0042 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0042 0.0042
Brugia malayi hypothetical protein 0.0042 0.0042 0.0042
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0014 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0038 0.0295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0033 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0572 0.123 0.123

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 72 uM In vitro inhibition of CETP activity was assessed by measuring the rate of [3H]- cholesteryl ester transfer from HDL to apoprotein B-containing lipoproteins in human plasma ChEMBL. 15109658
IC50 (binding) = 72 uM In vitro inhibition of CETP activity was assessed by measuring the rate of [3H]- cholesteryl ester transfer from HDL to apoprotein B-containing lipoproteins in human plasma ChEMBL. 15109658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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