Detailed information for compound 1448792

Basic information

Technical information
  • TDR Targets ID: 1448792
  • Name: 2-[(1S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-di hydroxyphenyl)-3-methyl-1-cyclohex-2-enyl]-1, 3,5a,8-tetrahydroxy-10a-(3-methylbut-2-enyl)- [1]benzoxolo[3,2-b]chromen-11-one
  • MW: 708.707 | Formula: C40H36O12
  • H donors: 8 H acceptors: 10 LogP: 6.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(=CCC12Oc3c(C2(O)Oc2c(C1=O)c(O)c(c(c2)O)[C@H]1C=C(C)CC([C@H]1C(=O)c1ccc(cc1O)O)c1ccc(cc1O)O)ccc(c3)O)C
  • InChi: 1S/C40H36O12/c1-18(2)10-11-39-38(49)35-32(52-40(39,50)27-9-6-22(43)16-31(27)51-39)17-30(46)34(37(35)48)26-13-19(3)12-25(23-7-4-20(41)14-28(23)44)33(26)36(47)24-8-5-21(42)15-29(24)45/h4-10,13-17,25-26,33,41-46,48,50H,11-12H2,1-3H3/t25?,26-,33+,39?,40?/m0/s1
  • InChiKey: SUOXGDJCEWTZIZ-BQXUNMGUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(1S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-1-cyclohex-2-enyl]-1,3,5a,8-tetrahydroxy-10a-(3-methylbut-2-enyl)benzofurano[3,2-b]chromen-11-one
  • 2-[(1S,6R)-5-(2,4-dihydroxyphenyl)-6-[(2,4-dihydroxyphenyl)-oxomethyl]-3-methyl-1-cyclohex-2-enyl]-1,3,5a,8-tetrahydroxy-10a-(3-methylbut-2-enyl)-11-benzofurano[3,2-b]chromenone
  • 2-[(1S,6R)-5-(2,4-dihydroxyphenyl)-6-(2,4-dihydroxyphenyl)carbonyl-3-methyl-1-cyclohex-2-enyl]-1,3,5a,8-tetrahydroxy-10a-(3-methylbut-2-enyl)-[1]benzoxolo[3,2-b]chromen-11-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0331 0.1373
Onchocerca volvulus 0.0236 0.146 0.1983
Onchocerca volvulus 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0082 0.0436 0.0592
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0236 0.146 0.146
Echinococcus granulosus hypothetical protein 0.0236 0.146 0.146
Echinococcus granulosus 7tm_1 domain containing protein 0.0236 0.146 0.146
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0598 0.2485
Onchocerca volvulus 0.0021 0.0029 0.0039
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus multilocularis g protein coupled receptor 0.0236 0.146 0.146
Echinococcus granulosus Endonuclease G 0.0313 0.1972 0.1972
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0236 0.146 0.146
Echinococcus granulosus neuropeptides capa receptor 0.0236 0.146 0.146
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Mycobacterium ulcerans beta-lactamase 0.0038 0.0141 0.0586
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0236 0.146 0.146
Onchocerca volvulus 0.0026 0.0066 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0598 0.2485
Echinococcus multilocularis somatostatin receptor 0.0236 0.146 0.146
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0141 0.0865
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0066 0.0331 0.1677
Onchocerca volvulus 0.0038 0.0141 0.0192
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.146 0.146
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0275 0.0275
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0262 0.1632 1
Onchocerca volvulus 0.0236 0.146 0.1983
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0066 0.0331 0.1373
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0082 0.0436 0.0592
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0029 0.1665
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0236 0.146 0.146
Brugia malayi hypothetical protein 0.0021 0.0029 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0667 0.3385
Echinococcus multilocularis g protein coupled receptor 0.0236 0.146 0.146
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0703 0.4556 0.4556
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1126 0.7366 1
Schistosoma mansoni amine GPCR 0.0236 0.146 0.146
Onchocerca volvulus 0.0026 0.0066 0.0089
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0236 0.146 0.1983
Schistosoma mansoni microtubule-associated protein tau 0.1523 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0403 0.2044
Schistosoma mansoni growth hormone secretagogue receptor 0.0236 0.146 0.146
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0118 0.0673 0.0673
Schistosoma mansoni biogenic amine receptor 0.0236 0.146 0.146
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0118 0.0673 0.0673
Brugia malayi hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0236 0.146 0.146
Brugia malayi Thrombospondin type 1 domain containing protein 0.1126 0.7366 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0236 0.146 0.146
Echinococcus multilocularis geminin 0.0205 0.125 0.125
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0028 0.0142
Schistosoma mansoni loxhd1 0.0021 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0026 0.0066 0.0089
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Echinococcus granulosus ectonucleotide 0.044 0.281 0.281
Echinococcus multilocularis neuropeptide receptor 0.0236 0.146 0.146
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0236 0.146 0.146
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0028 0.0142
Loa Loa (eye worm) hypothetical protein 0.0522 0.3354 0.4554
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0082 0.0436 0.0436
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.0224
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0703 0.4556 0.4556
Brugia malayi G protein-coupled receptor F59B2.13 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0236 0.146 0.146
Mycobacterium leprae Probable lipase LipE 0.0038 0.0141 0.3235
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0236 0.146 0.146
Brugia malayi beta-lactamase family protein 0.0038 0.0141 0.0192
Onchocerca volvulus 0.0236 0.146 0.1983
Brugia malayi polk-prov protein 0.0021 0.0028 0.0038
Brugia malayi hypothetical protein 0.0021 0.0029 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.1226 0.8026 0.8026
Brugia malayi larval opioid receptor 0.0236 0.146 0.1983
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0141 0.0586
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0082 0.0436 0.2213
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0673 0.3412
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0026 0.0066 0.0066
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus biogenic amine 5HT receptor 0.0236 0.146 0.146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0379 0.2408 1
Echinococcus granulosus GPCR family 2 0.0019 0.0018 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.146 0.146
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0066 0.0066
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0236 0.146 0.146
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus serotonin receptor 0.0236 0.146 0.146
Echinococcus multilocularis neuropeptides capa receptor 0.0236 0.146 0.146
Schistosoma mansoni hypothetical protein 0.0205 0.125 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0194 0.0986
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0082 0.0436 0.1812
Trypanosoma brucei unspecified product 0.0066 0.0331 0.1677
Loa Loa (eye worm) hypothetical protein 0.044 0.281 0.3814
Schistosoma mansoni DNA polymerase eta 0.0123 0.0706 0.0706
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Echinococcus granulosus allatostatin A receptor 0.0236 0.146 0.146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0291 0.0395
Echinococcus multilocularis transcription factor btf3 0.0042 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0082 0.0436 0.0592
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0331 0.0449
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.1065 0.1446
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Leishmania major hypothetical protein, conserved 0.0038 0.0141 0.0716
Entamoeba histolytica hypothetical protein 0.0073 0.0379 0.1573
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0236 0.146 0.146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Entamoeba histolytica hypothetical protein 0.0042 0.0172 0.0714
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0141 0.0141
Brugia malayi hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0018 0.0025
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0026 0.0066 0.0089
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0066 0.0066
Trypanosoma brucei unspecified product 0.0046 0.0194 0.0986
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0028 0.0142
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.0066 0.0331 0.0331
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.044 0.281 0.281
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0703 0.4556 0.4556
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0236 0.146 0.146
Onchocerca volvulus 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis g protein coupled receptor 0.0236 0.146 0.146
Leishmania major tyrosine specific protein phosphatase, putative 0.0026 0.0066 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1129 0.4687
Leishmania major hypothetical protein, conserved 0.0117 0.0667 0.3385
Echinococcus multilocularis microtubule associated protein 2 0.1523 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0066 0.0331 0.0331
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0522 0.3354 0.4554
Echinococcus multilocularis g-protein coupled receptor 0.0236 0.146 0.146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Brugia malayi CXXC zinc finger family protein 0.0031 0.01 0.0136
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0236 0.146 0.1983
Entamoeba histolytica hypothetical protein 0.0073 0.0379 0.1573
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Echinococcus granulosus protein tyrosine phosphatase n9 0.0026 0.0066 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0141 0.0586
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Brugia malayi Doublecortin family protein 0.0021 0.0029 0.0039
Schistosoma mansoni neuropeptide receptor 0.0236 0.146 0.146
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Echinococcus granulosus sex peptide receptor 0.0236 0.146 0.146
Schistosoma mansoni hypothetical protein 0.0073 0.0379 0.0379
Echinococcus granulosus dna polymerase kappa 0.0066 0.0331 0.0331
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Brugia malayi G protein-coupled receptor 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1129 0.4687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Brugia malayi hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0379 0.0379
Schistosoma mansoni alpha-1 adrenergic receptor 0.0236 0.146 0.146
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0141 0.0865
Echinococcus multilocularis G-protein coupled receptor, putative 0.0236 0.146 0.146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0117 0.0667 0.2772
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0148 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Echinococcus multilocularis allatostatin A receptor 0.0236 0.146 0.146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0148 1
Echinococcus multilocularis fmrfamide receptor 0.0236 0.146 0.146
Schistosoma mansoni opsin-like receptor 0.0236 0.146 0.146
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0026 0.0066 0.0089
Echinococcus granulosus transferase 0.0082 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0673 0.2794
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0331 0.1677
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0066 0.0066
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0379 0.2408 1
Onchocerca volvulus 0.0031 0.01 0.0136
Brugia malayi Dopamine receptor protein 1 0.0236 0.146 0.1983
Trypanosoma brucei protein tyrosine phosphatase 1 0.0026 0.0066 0.0333
Echinococcus multilocularis G protein coupled receptor 139 0.0236 0.146 0.146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0209 0.0209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Schistosoma mansoni neuropeptide receptor 0.0236 0.146 0.146
Brugia malayi sulfakinin receptor protein 0.0236 0.146 0.1983
Brugia malayi Tachykinin-like peptides receptor 99D 0.0236 0.146 0.1983
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0379 0.2408 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Brugia malayi Inositol-1 0.0039 0.0148 0.02
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0141 0.0865
Onchocerca volvulus 0.0026 0.0066 0.0089
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0236 0.146 0.146
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0379 0.2408 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0082 0.0436 0.0592
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0148 0.0749
Loa Loa (eye worm) G-protein coupled receptor 0.0236 0.146 0.1983
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0082 0.0436 0.0592
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0522 0.3354 0.4554
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0667 0.3385
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0598 0.0598
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0066 0.0331 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.1485 0.9098
Onchocerca volvulus 0.0038 0.0141 0.0192
Echinococcus multilocularis neuropeptide Y receptor 0.0236 0.146 0.146
Giardia lamblia Protein tyrosine phosphatase 0.0026 0.0066 0.0273
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0026 0.0066 0.0066
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0598 0.3034
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0028 0.0142
Leishmania major DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Schistosoma mansoni polycystin 1-related 0.0021 0.0029 0.0029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0236 0.146 0.1983
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0703 0.4556 0.6185
Echinococcus granulosus cpg binding protein 0.0033 0.0112 0.0112
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0236 0.146 0.1983
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0236 0.146 0.146
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0148 0.0613
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0148 0.0148
Onchocerca volvulus 0.0236 0.146 0.1983
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0236 0.146 0.146
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0082 0.0436 0.0436
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.1681 0.2281
Brugia malayi AEL166Cp 0.0082 0.0436 0.0592
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Onchocerca volvulus 0.0236 0.146 0.1983
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0172 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0028 0.0142
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0848 0.1152
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0236 0.146 0.146
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0275 0.0275
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0477 0.3057 0.415
Loa Loa (eye worm) hypothetical protein 0.0118 0.0673 0.0913
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Leishmania major DNA polymerase kappa, putative 0.0021 0.0028 0.0142
Entamoeba histolytica deoxycytidyl transferase, putative 0.0066 0.0331 0.1373
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Brugia malayi AKH receptor 0.0236 0.146 0.1983
Schistosoma mansoni hypothetical protein 0.0082 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Brugia malayi Dopamine receptor 0.0236 0.146 0.1983
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0287 0.1453
Schistosoma mansoni hypothetical protein 0.0205 0.125 0.125
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0026 0.0066 0.0089
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0236 0.146 0.146
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0236 0.146 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0236 0.146 0.1983
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0082 0.0436 0.0436
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0148 0.0613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0379 0.2408 0.3269
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0331 0.2026
Onchocerca volvulus 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0522 0.3354 0.4554
Echinococcus granulosus geminin 0.0205 0.125 0.125
Schistosoma mansoni hypothetical protein 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Treponema pallidum ribonuclease Z 0.0016 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0209 0.0209
Schistosoma mansoni lipoxygenase 0.0058 0.0275 0.0275
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0172 0.0233
Brugia malayi hypothetical protein 0.0026 0.0066 0.0089
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0028 0.0142
Schistosoma mansoni DNA polymerase IV / kappa 0.0021 0.0028 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0673 0.3412
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.01 0.0136
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0598 0.3034
Echinococcus granulosus g protein coupled receptor 0.0236 0.146 0.146
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0026 0.0066 0.0066
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0028 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0029
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0598 0.0598
Echinococcus granulosus biogenic amine 5HT receptor 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0236 0.146 0.1983
Echinococcus multilocularis transferase 0.0082 0.0436 0.0436
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0379 0.2408 0.3269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Brugia malayi Dopamine receptor protein 2 0.0236 0.146 0.1983
Echinococcus granulosus tachykinin peptides receptor 99D 0.0236 0.146 0.146
Loa Loa (eye worm) beta-lactamase 0.0038 0.0141 0.0192
Brugia malayi RE15519p 0.0236 0.146 0.1983
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis neuropeptide receptor 0.0236 0.146 0.146
Plasmodium falciparum DNA repair protein REV1, putative 0.0021 0.0028 0.0642
Echinococcus multilocularis neuropeptide Y receptor 0.0236 0.146 0.146
Echinococcus granulosus neuropeptide FF receptor 2 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.006 0.0291 0.0395
Loa Loa (eye worm) hypothetical protein 0.0522 0.3354 0.4554
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0598 0.2485
Trichomonas vaginalis pten, drome, putative 0.0026 0.0066 0.0273
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0141 0.0141
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0026 0.0066 0.0089
Trypanosoma cruzi endonuclease G, putative 0.0313 0.1972 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0118 0.0673 0.2794
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0066 0.0331 0.0331
Giardia lamblia DINP protein human, muc B family 0.0066 0.0331 0.1373
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0236 0.146 0.1983
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0236 0.146 0.146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0082 0.0436 0.0592
Onchocerca volvulus 0.0026 0.0066 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Mycobacterium ulcerans hypothetical protein 0.0082 0.0436 0.1812
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Onchocerca volvulus Huntingtin homolog 0.0121 0.0695 0.0943
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0673 0.2794
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Echinococcus multilocularis Endonuclease G 0.0313 0.1972 0.1972
Giardia lamblia DNA damage repair protein 0.0021 0.0028 0.0116
Onchocerca volvulus 0.0026 0.0066 0.0089
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0082 0.0436 0.0436
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0313 0.1972 1
Schistosoma mansoni hypothetical protein 0.0041 0.0165 0.0165
Brugia malayi Protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Echinococcus granulosus neuropeptide receptor 0.0236 0.146 0.146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Echinococcus multilocularis hypothetical protein 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0026 0.0066 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0141 0.0716
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0172 0.3941
Onchocerca volvulus 0.0038 0.0141 0.0192
Leishmania major DNA damage repair protein, putative 0.0021 0.0028 0.0142
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0141 0.0586
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0141 0.0716
Brugia malayi hypothetical protein 0.0121 0.0695 0.0943
Leishmania major DNA polymerase eta, putative 0.0077 0.0403 0.2044
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0029
Onchocerca volvulus 0.0026 0.0066 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0194 0.0986
Schistosoma mansoni cpg binding protein 0.0033 0.0112 0.0112
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0598 0.3034
Onchocerca volvulus 0.0021 0.0029 0.0039
Trypanosoma brucei endonuclease G, putative 0.0313 0.1972 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0028 0.0142
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0379 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0172 0.0714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Trypanosoma brucei protein kinase, putative 0.0106 0.0598 0.3034
Brugia malayi hypothetical protein 0.0082 0.0436 0.0592
Echinococcus multilocularis dna polymerase eta 0.0123 0.0706 0.0706
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Echinococcus multilocularis neuropeptide FF receptor 2 0.0236 0.146 0.146
Schistosoma mansoni hypothetical protein 0.0082 0.0436 0.0436
Entamoeba histolytica hypothetical protein 0.0073 0.0379 0.1573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0236 0.146 0.146
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0141 0.0865
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Onchocerca volvulus 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0026 0.0066 0.0066
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0117 0.0667 0.2772
Brugia malayi follicle stimulating hormone receptor 0.0477 0.3057 0.415
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0379 0.2408 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0148 0.0613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Echinococcus granulosus g-protein coupled receptor 0.0236 0.146 0.146
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0172 0.0872
Trypanosoma cruzi DNA polymerase eta, putative 0.0123 0.0706 0.3579
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0522 0.3354 0.3354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Echinococcus granulosus neuropeptide receptor 0.0236 0.146 0.146
Brugia malayi putative neuropeptide receptor 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0018
Schistosoma mansoni transcription factor btf3 0.0042 0.0172 0.0172
Echinococcus granulosus orexin receptor type 2 0.0236 0.146 0.146
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0029
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0313 0.1972 1
Schistosoma mansoni lipoxygenase 0.0021 0.0029 0.0029
Plasmodium vivax DNA repair protein REV1, putative 0.0021 0.0028 0.1628
Schistosoma mansoni amine GPCR 0.0236 0.146 0.146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0334 0.0334
Echinococcus granulosus dna polymerase eta 0.0123 0.0706 0.0706
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0121 0.2769
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0291 0.0395
Echinococcus multilocularis sex peptide receptor 0.0236 0.146 0.146
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0522 0.3354 0.3354
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0172 0.0714
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis neuropeptides capa receptor 0.0236 0.146 0.146
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0082 0.0436 0.0592
Schistosoma mansoni biogenic amine receptor 0.0236 0.146 0.146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0236 0.146 0.146
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0172 0.0714
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0148 0.0613
Echinococcus multilocularis fmrfamide receptor 0.0236 0.146 0.146
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0172 0.0714
Brugia malayi MAP kinase sur-1 0.0106 0.0598 0.0812
Echinococcus multilocularis orexin receptor type 2 0.0236 0.146 0.146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0236 0.146 0.1983
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Schistosoma mansoni adenoreceptor 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0029 0.0656
Trypanosoma brucei DNA polymerase eta, putative 0.0123 0.0706 0.3579
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0598 0.0812
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0236 0.146 0.146
Loa Loa (eye worm) inositol-1 0.0039 0.0148 0.02
Echinococcus multilocularis serotonin receptor 0.0236 0.146 0.146
Echinococcus granulosus 7TM GPCR rhodopsin 0.0236 0.146 0.146
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0236 0.146 0.146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Loa Loa (eye worm) TYRA-2 protein 0.0236 0.146 0.1983
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0236 0.146 0.146
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0066 0.0333
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Echinococcus granulosus neuropeptide Y receptor 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Brugia malayi Protein-tyrosine phosphatase 1 0.0026 0.0066 0.0089
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0066 0.0333
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0172 0.0872
Schistosoma mansoni hypothetical protein 0.1126 0.7366 0.7366
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0141 0.0586
Schistosoma mansoni inositol monophosphatase 0.0039 0.0148 0.0148
Brugia malayi Melatonin receptor type 1A 0.0236 0.146 0.1983
Echinococcus multilocularis GPCR, family 2 0.0019 0.0018 0.0018
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0141 0.0192
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0148 0.0749
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0026 0.0066 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0598 0.0598
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0379 0.2408 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0598 0.3034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0703 0.4556 0.6185
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0141 0.0865
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0141 0.0586
Mycobacterium ulcerans hypothetical protein 0.0038 0.0141 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0236 0.146 0.146
Schistosoma mansoni protein tyrosine phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Echinococcus granulosus tm gpcr rhodopsin 0.0236 0.146 0.146
Onchocerca volvulus 0.0026 0.0066 0.0089
Brugia malayi Protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0082 0.0436 0.0592
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0026 0.0066 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0331 0.1677
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0028 0.0142
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0236 0.146 0.146
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0026 0.0066 0.0066
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0118 0.0673 0.0913
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0026 0.0066 0.0333
Onchocerca volvulus 0.0026 0.0066 0.0089
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0313 0.1972 1
Echinococcus granulosus transcription factor btf3 0.0042 0.0172 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Onchocerca volvulus Huntingtin homolog 0.0121 0.0695 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0209 0.0209
Echinococcus granulosus fmrfamide receptor 0.0236 0.146 0.146
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0313 0.1972 1
Brugia malayi G-protein coupled receptor 0.0236 0.146 0.1983
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0236 0.146 0.146
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0148 0.0613
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0026 0.0066 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0165 0.0224
Onchocerca volvulus 0.0236 0.146 0.1983
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0598 0.2485
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0018
Brugia malayi G-protein coupled receptor 0.0236 0.146 0.1983
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0236 0.146 0.1983
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0194 0.0986
Toxoplasma gondii ABC1 family protein 0.0038 0.0141 0.0716
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Schistosoma mansoni pcd6 interacting protein-related 0.0026 0.0066 0.0066
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.044 0.281 0.281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0209 0.0209
Schistosoma mansoni cpg binding protein 0.0033 0.0112 0.0112
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0121 0.0695 0.0943
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0026 0.0066 0.0273
Brugia malayi beta-NAC-like protein 0.0042 0.0172 0.0233
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.1681 0.2281
Echinococcus granulosus neuropeptides capa receptor 0.0236 0.146 0.146
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0236 0.146 0.146
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0598 0.3034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0082 0.0436 0.0436
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0082 0.0436 0.0436
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0148 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0379 0.2408 1
Echinococcus multilocularis 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Onchocerca volvulus 0.0026 0.0066 0.0089
Loa Loa (eye worm) melatonin receptor type 1A 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Schistosoma mansoni endonuclease related 0.0313 0.1972 0.1972
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0082 0.0436 0.0592
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0141 0.8209
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0028 0.0142
Onchocerca volvulus 0.1126 0.7366 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0038 0.0141 0.0865
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Schistosoma mansoni neuropeptide receptor 0.0236 0.146 0.146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0018
Trypanosoma brucei endonuclease G, putative 0.0313 0.1972 1
Brugia malayi ImpB/MucB/SamB family protein 0.0123 0.0706 0.0958
Brugia malayi neuropeptide F receptor 0.0236 0.146 0.1983
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0026 0.0066 0.0333
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0026 0.0066 0.0066
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0026 0.0066 0.0066
Schistosoma mansoni amine GPCR 0.0236 0.146 0.146
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Onchocerca volvulus 4.1 G protein, putative homolog 0.0026 0.0066 0.0089
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0066 0.0331 0.0449
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0026 0.0066 0.0066
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0379 0.2408 1
Brugia malayi Serotonin receptor 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis dna polymerase kappa 0.0066 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0141 0.0192
Brugia malayi Serotonin receptor 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0673 0.0673
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0379 0.2408 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Echinococcus granulosus g protein coupled receptor 0.0236 0.146 0.146
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0118 0.0673 0.2794
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0236 0.146 0.1983
Leishmania major basic transcription factor 3a, putative 0.0042 0.0172 0.0872
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0848 0.1152
Mycobacterium leprae hypothetical protein 0.0082 0.0436 1
Schistosoma mansoni hypothetical protein 0.0236 0.146 0.146
Schistosoma mansoni amine GPCR 0.0236 0.146 0.146
Schistosoma mansoni hypothetical protein 0.0236 0.146 0.146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0236 0.146 0.146
Brugia malayi beta-lactamase 0.0038 0.0141 0.0192
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0141 0.3235
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0236 0.146 0.1983
Brugia malayi putative neuropeptide receptor NPR1 0.0236 0.146 0.1983
Onchocerca volvulus 0.0522 0.3354 0.4554
Onchocerca volvulus 0.0026 0.0066 0.0089
Brugia malayi hypothetical protein 0.0073 0.0379 0.0514
Schistosoma mansoni neuropeptide f receptor 76f 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Onchocerca volvulus 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Echinococcus granulosus neuropeptide Y receptor 0.0236 0.146 0.146
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0236 0.146 0.1983
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0673 0.0673
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0141 0.0865
Brugia malayi MH2 domain containing protein 0.0144 0.0848 0.1152
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0598 0.3034
Loa Loa (eye worm) hypothetical protein 0.0123 0.0706 0.0958
Trichomonas vaginalis DNA polymerase eta, putative 0.0066 0.0331 0.1373
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Echinococcus granulosus alpha 1A adrenergic receptor 0.0236 0.146 0.146
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis RUN 0.0021 0.0029 0.0029
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0236 0.146 0.146
Echinococcus multilocularis serotonin receptor 0.0236 0.146 0.146
Onchocerca volvulus 0.0236 0.146 0.1983
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0082 0.0436 0.0592
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0598 0.2485
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0209 0.0283
Leishmania major endonuclease G, putative 0.0313 0.1972 1
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Schistosoma mansoni myosin xvIII 0.0236 0.146 0.146
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0026 0.0066 0.0066
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0117 0.0667 0.3385
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0141 0.0716
Onchocerca volvulus Neuropeptide F receptor homolog 0.0236 0.146 0.1983
Chlamydia trachomatis ribonuclease Z 0.0016 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0236 0.146 0.1983
Leishmania major ethanolamine phosphotransferase, putative 0.0082 0.0436 0.2213
Onchocerca volvulus 0.0236 0.146 0.1983
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0141 0.0586
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0192
Trypanosoma brucei unspecified product 0.0046 0.0194 0.0986
Onchocerca volvulus 0.0236 0.146 0.1983
Schistosoma mansoni neuropeptide F-like receptor 0.0236 0.146 0.146
Echinococcus multilocularis ubiquitin specific protease 41 0.0118 0.0673 0.0673
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0066 0.0331 0.2026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0028 0.0142
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus tm gpcr rhodopsin 0.0236 0.146 0.146
Brugia malayi hypothetical protein 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0026 0.0066 0.0089
Schistosoma mansoni hypothetical protein 0.0082 0.0436 0.0436
Brugia malayi neuropeptide F receptor 0.0236 0.146 0.1983
Mycobacterium ulcerans DNA polymerase IV 0.0066 0.0331 0.1373
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0236 0.146 0.146
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0121 0.074
Trypanosoma brucei DNA polymerase IV, putative 0.0066 0.0331 0.1677
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0118 0.0673 0.3412
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0082 0.0436 0.0436
Onchocerca volvulus 0.0026 0.0066 0.0089
Onchocerca volvulus 0.0026 0.0066 0.0089
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0673 0.0673
Echinococcus multilocularis ectonucleotide 0.044 0.281 0.281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0209 0.0209
Echinococcus granulosus ubiquitin specific protease 41 0.0118 0.0673 0.0673
Echinococcus multilocularis neuropeptide s receptor 0.1226 0.8026 0.8026
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0379 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0148 0.0749
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0172 0.0872
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0026 0.0066 0.0089
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0236 0.146 0.146
Schistosoma mansoni opsin-like receptor 0.0236 0.146 0.146
Schistosoma mansoni cpg binding protein 0.0031 0.01 0.01
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0673 0.3412
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Loa Loa (eye worm) protein tyrosine phosphatase 0.0026 0.0066 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0291 0.0395
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0403 0.2044
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0082 0.0436 0.0592
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0026 0.0066 0.0273
Loa Loa (eye worm) hypothetical protein 0.0121 0.0695 0.0943
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0029 0.0029
Mycobacterium tuberculosis Conserved protein 0.0038 0.0141 0.0865
Onchocerca volvulus 0.0026 0.0066 0.0089
Echinococcus multilocularis cpg binding protein 0.0033 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0028 0.0142
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0236 0.146 0.146
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0598 0.3034
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0236 0.146 0.146
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus granulosus RUN 0.0021 0.0029 0.0029
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0026 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0236 0.146 0.146
Schistosoma mansoni histamine h1 receptor 0.0236 0.146 0.146
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0141 0.0586
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0172 0.0872
Schistosoma mansoni hypothetical protein 0.0082 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0026 0.0066 0.0066
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0082 0.0436 0.1812
Echinococcus granulosus peptide allatostatin:somatostatin 0.0236 0.146 0.146
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0522 0.3354 0.3354
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis neuropeptide receptor A26 0.1226 0.8026 0.8026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus granulosus neuropeptide s receptor 0.1226 0.8026 0.8026
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0148 0.0749
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0141 0.0865
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0039
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0082 0.0436 0.1812
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Trypanosoma cruzi endonuclease G, putative 0.0313 0.1972 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0379 0.2408 1
Trypanosoma brucei endonuclease G, putative 0.0313 0.1972 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0141 0.0586
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0141 0.0141
Brugia malayi beta-lactamase family protein 0.0038 0.0141 0.0192
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0673 0.2794
Onchocerca volvulus 0.0236 0.146 0.1983
Schistosoma mansoni neuropeptide receptor 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis dro:myosuppressin receptor 0.0236 0.146 0.146
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Echinococcus granulosus g protein coupled receptor 0.0236 0.146 0.146
Trypanosoma brucei chrX additional, unordered contigs 0.0021 0.0028 0.0142
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0026 0.0066 0.0066
Onchocerca volvulus 0.0026 0.0066 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1065 0.4425
Schistosoma mansoni inositol monophosphatase 0.0039 0.0148 0.0148
Brugia malayi GnHR receptor homolog 0.0236 0.146 0.1983
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0598 0.0598
Brugia malayi hypothetical protein 0.0082 0.0436 0.0592
Onchocerca volvulus 0.0026 0.0066 0.0089
Schistosoma mansoni opsin-like receptor 0.0236 0.146 0.146
Brugia malayi endonuclease G, mitochondrial precursor 0.0313 0.1972 0.2677
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0379 0.2408 0.3269
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Loa Loa (eye worm) G-protein coupled receptor 0.0236 0.146 0.1983
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0209 0.0209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Loa Loa (eye worm) neuropeptide F receptor 0.0236 0.146 0.1983
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0073 0.0379 0.1573
Brugia malayi hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0082 0.0436 0.0436
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0026 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0331 0.1677
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Echinococcus granulosus G protein coupled receptor 139 0.0236 0.146 0.146
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1681 0.6979
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0522 0.3354 0.3354
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0026 0.0066 0.0066
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0236 0.146 0.146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0026 0.0066 0.0089
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0026 0.0066 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0236 0.146 0.1983
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0082 0.0436 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0026 0.0066 0.0066
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0029 0.0039
Echinococcus granulosus dro:myosuppressin receptor 0.0236 0.146 0.146
Echinococcus granulosus somatostatin receptor 0.0236 0.146 0.146
Mycobacterium ulcerans hypothetical protein 0.0021 0.0028 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0018 0.0025
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0209 0.0283
Trichomonas vaginalis esterase, putative 0.0038 0.0141 0.0586
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0026 0.0066 0.0089
Leishmania major DNA polymerase eta, putative 0.0123 0.0706 0.3579
Loa Loa (eye worm) hypothetical protein 0.0236 0.146 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0236 0.146 0.146
Onchocerca volvulus 0.0026 0.0066 0.0089
Mycobacterium tuberculosis Conserved protein 0.0038 0.0141 0.0865
Schistosoma mansoni biogenic amine (5HT) receptor 0.0236 0.146 0.146
Schistosoma mansoni amine GPCR 0.0236 0.146 0.146
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0598 0.3034
Schistosoma mansoni biogenic amine receptor 0.0236 0.146 0.146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0236 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0089

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.206 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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