Detailed information for compound 1486917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.422 | Formula: C22H22F3N3O5
  • H donors: 2 H acceptors: 5 LogP: 2.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.O=C(Nc1nccc(c1)C)CCCOc1cc(=O)n(c2c1cccc2)C
  • InChi: 1S/C20H21N3O3.C2HF3O2/c1-14-9-10-21-18(12-14)22-19(24)8-5-11-26-17-13-20(25)23(2)16-7-4-3-6-15(16)17;3-2(4,5)1(6)7/h3-4,6-7,9-10,12-13H,5,8,11H2,1-2H3,(H,21,22,24);(H,6,7)
  • InChiKey: JAOINXWEFKZYIL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens WEE1 G2 checkpoint kinase Starlite/ChEMBL No references
Herpes simplex virus (type 1 / strain 17) Alpha trans-inducing protein (VP16) Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group E, member 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani Wee1-like protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania donovani protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania infantum protein kinase, putative,serine/threonine protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Brugia malayi photoreceptor-specific nuclear receptor Get druggable targets OG5_135311 All targets in OG5_135311
Trypanosoma congolense Wee1-like protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135311 All targets in OG5_135311
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania mexicana protein kinase, putative,serine/threonine protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Trypanosoma brucei wee1-like protein kinase Get druggable targets OG5_129875 All targets in OG5_129875
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi Wee1-like protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Trypanosoma cruzi Wee1-like protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania braziliensis protein kinase, putative,serine/threonine protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Trypanosoma cruzi Wee1-like protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_129875 All targets in OG5_129875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Nuclear hormone receptor family member nhr-49 nuclear receptor subfamily 2, group E, member 3 410 aa 384 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0035 0.0317 0.036
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0093 0.0264
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0282 0.0792
Mycobacterium ulcerans hypothetical protein 0.0278 0.3078 1
Brugia malayi Muscleblind-like protein 0.0163 0.1781 0.5183
Onchocerca volvulus 0.026 0.2878 0.9347
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0373 0.0425
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.019 0.0209
Brugia malayi ecdysteroid receptor 0.0023 0.019 0.052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1164 0.3375
Loa Loa (eye worm) histone methyltransferase 0.0011 0.005 0.011
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Echinococcus multilocularis muscleblind protein 1 0.0163 0.1781 0.1771
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.1149 0.1339
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0048 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.019 0.052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.1149 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0278 0.3078 0.3612
Brugia malayi CHE-14 protein 0.0046 0.045 0.1284
Brugia malayi hypothetical protein 0.0278 0.3078 0.8981
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0065 0.0155
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.019 0.0178
Schistosoma mansoni DNA ligase IV 0.0011 0.0048 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.1284
Onchocerca volvulus 0.0056 0.0557 0.1778
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0008 0.0014 0.0003
Schistosoma mansoni smad1 5 8 and 0.001 0.0037 0.0029
Schistosoma mansoni peptidase 0.001 0.0034 0.0026
Schistosoma mansoni peptidase 0.001 0.0034 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.019 0.052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0898
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1168 0.1362
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Toxoplasma gondii zinc carboxypeptidase, putative 0.001 0.0034 0.0364
Brugia malayi nuclear receptor RXR 0.0011 0.005 0.0112
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0023 0.019 0.2554
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Schistosoma mansoni hypothetical protein 0.0035 0.0317 0.036
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0069 0.071 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0037 0.0029
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0034 0.0314
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0145
Loa Loa (eye worm) hypothetical protein 0.0046 0.0449 0.1279
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.019 0.052
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0069 0.071 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.019 0.0209
Onchocerca volvulus 0.003 0.0261 0.0811
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0087 0.0089
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.019 0.0579
Loa Loa (eye worm) hypothetical protein 0.0075 0.0772 0.2227
Loa Loa (eye worm) hypothetical protein 0.0035 0.0317 0.0895
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.022 0.183
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.195 0.5676
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.005 0.0045
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0037 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.019 0.052
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.019 0.052
Onchocerca volvulus 0.0031 0.0282 0.0882
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1164 0.3375
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0034 0.0314
Plasmodium vivax SET domain protein, putative 0.0033 0.0304 1
Trypanosoma cruzi zinc carboxypeptidase, putative 0.001 0.0034 0.0314
Schistosoma mansoni thyroid hormone receptor 0.0023 0.019 0.0209
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.019 0.052
Schistosoma mansoni nuclear receptor 0.0011 0.005 0.0045
Echinococcus multilocularis enteropeptidase 0.0278 0.3078 0.307
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0093 0.0301
Brugia malayi hypothetical protein 0.0259 0.2863 0.8352
Echinococcus multilocularis expressed conserved protein 0.0101 0.1075 0.1064
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0375 0.0363
Trypanosoma cruzi prolyl endopeptidase 0.0059 0.0591 0.8298
Echinococcus granulosus enteropeptidase 0.0278 0.3078 0.3612
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.3171
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.3171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.019 0.052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0375 0.5196
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0375 0.0427
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.005 0.0112
Brugia malayi hypothetical protein 0.0039 0.0373 0.1056
Schistosoma mansoni intermediate filament proteins 0.003 0.0261 0.0293
Brugia malayi hypothetical protein 0.0011 0.005 0.0112
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.001 0.0034 0.0364
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0012 0.0231
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0056 0.0557 0.0642
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Schistosoma mansoni netrin receptor unc5 0.0035 0.0318 0.0361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.019 0.0178
Onchocerca volvulus 0.0278 0.3078 1
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0056 0.0557 0.0546
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0146 0.2793
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.022 0.0679
Schistosoma mansoni nuclear receptor 0.0011 0.005 0.0045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0375 0.1283
Onchocerca volvulus 0.0033 0.0304 0.0953
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.019 0.0178
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0034 0.0314
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0093 0.0301
Toxoplasma gondii prolyl endopeptidase 0.0059 0.0591 0.9602
Echinococcus granulosus GPCR family 2 0.0035 0.0317 0.036
Echinococcus granulosus smad 0.001 0.0037 0.0029
Treponema pallidum DNA ligase (lig) 0.0011 0.0048 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0023 0.019 0.2554
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.022 0.2981
Echinococcus multilocularis Smad4 0.001 0.0037 0.0025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0028 0.0016
Brugia malayi Hemopexin family protein 0.0011 0.0051 0.0115
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.019 0.0209
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.005 0.0045
Loa Loa (eye worm) intermediate filament protein 0.003 0.0261 0.0728
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0034 0.0314
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0375 0.1283
Brugia malayi photoreceptor-specific nuclear receptor 0.0308 0.3426 1
Echinococcus granulosus Mastin 0.0278 0.3078 0.3612
Echinococcus granulosus serine:threonine protein kinase Chk2 0.004 0.0385 0.0439
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0048 0.0513
Echinococcus granulosus Protein patched homolog 1 0.0046 0.045 0.0517
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.045 0.1547
Onchocerca volvulus 0.001 0.0034 0.0072
Brugia malayi topoisomerase 0.0011 0.0048 0.0105
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0591 0.1696
Onchocerca volvulus 0.0056 0.0557 0.1778
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.002
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0048 0.0594
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0037 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0145
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.001 0.0033 0.0063
Echinococcus granulosus Zinc carboxypeptidase family protein 0.001 0.0034 0.0026
Brugia malayi Matrixin family protein 0.0008 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0391
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0155
Schistosoma mansoni hypothetical protein 0.0053 0.0525 0.0604
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.005 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Loa Loa (eye worm) Smad1 0.001 0.0037 0.0073
Onchocerca volvulus 0.0056 0.0557 0.1778
Mycobacterium ulcerans hypothetical protein 0.0026 0.022 0.0679
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0023 0.019 0.8566
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0391
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0048 0.0145
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0034 0.0064
Loa Loa (eye worm) matrixin family protein 0.0019 0.014 0.0374
Onchocerca volvulus 0.0008 0.0014 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0373 0.0425
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0069 0.071 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.022 0.0679
Onchocerca volvulus 0.0278 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.2863 0.2855
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0059 0.0591 0.1696
Schistosoma mansoni alpha-glucosidase 0.0153 0.1668 0.1951
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0278 0.3078 0.307
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0261 0.0728
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0375 0.3191
Echinococcus multilocularis GPCR, family 2 0.0035 0.0317 0.0306
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.019 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0375 0.1283
Brugia malayi steroid hormone receptor 0.0023 0.019 0.052
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0034 0.0314
Mycobacterium leprae PROBABLE HYDROLASE 0.001 0.0033 0.1031
Echinococcus multilocularis musashi 0.003 0.0261 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0023 0.019 0.0209
Brugia malayi MH2 domain containing protein 0.001 0.0037 0.0073
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0087 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0145
Onchocerca volvulus 0.0053 0.0525 0.1672
Mycobacterium ulcerans hydrolase 0.001 0.0033 0.007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0019
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0012 0.0231
Brugia malayi nuclear receptor NHR-88 0.0011 0.005 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.022 0.183
Trypanosoma cruzi Carboxypeptidase-like protein 0.001 0.0034 0.0314
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Echinococcus granulosus prolyl endopeptidase 0.0059 0.0591 0.0682
Onchocerca volvulus Matrilysin homolog 0.0008 0.0014 0.0007
Echinococcus multilocularis nibrin 0.0011 0.0048 0.0036
Brugia malayi Trypsin family protein 0.0278 0.3078 0.8981
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0059 0.0591 0.0682
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0375 0.1283
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0065 0.0063
Schistosoma mansoni alpha-glucosidase 0.0153 0.1668 0.1951
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0093 0.1158
Schistosoma mansoni peptidase 0.001 0.0034 0.0026
Onchocerca volvulus Huntingtin homolog 0.0134 0.1448 0.4682
Schistosoma mansoni nuclear hormone receptor 0.0011 0.005 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0026 0.022 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.019 0.052
Brugia malayi MH1 domain containing protein 0.001 0.0037 0.0073
Onchocerca volvulus 0.001 0.0034 0.0072
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0048 0.0145
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Trypanosoma brucei wee1-like protein kinase 0.0069 0.071 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0048 0.0042
Leishmania major oligopeptidase b 0.0023 0.019 0.2554
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.045 0.0517
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0065 0.0053
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.022 0.2981
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0231
Onchocerca volvulus 0.0056 0.0557 0.1778
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0035 0.032 0.0363
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0093 0.0301
Brugia malayi ecdysone receptor 0.0011 0.005 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.019 0.052
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Echinococcus granulosus netrin receptor unc 5 0.0035 0.0318 0.0361
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.071
Loa Loa (eye worm) DR-78 0.0011 0.005 0.0112
Schistosoma mansoni hypothetical protein 0.0039 0.0373 0.0425
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0609
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0028 0.0248 0.0278
Echinococcus granulosus lamin 0.003 0.0261 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0317 0.0895
Trypanosoma cruzi oligopeptidase b 0.0023 0.019 0.2554
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0317 0.0306
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0093 0.0301
Brugia malayi hypothetical protein 0.0011 0.005 0.0112
Brugia malayi MH2 domain containing protein 0.001 0.0037 0.0073
Schistosoma mansoni coup transcription factor 0.0023 0.019 0.0209
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0304 0.0344
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0134 0.2563
Schistosoma mansoni smad1 5 8 and 0.001 0.0037 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0109 0.1164 0.3375
Schistosoma mansoni smad 0.001 0.0037 0.0029
Echinococcus multilocularis Mastin 0.0278 0.3078 0.307
Brugia malayi nuclear receptor NHR-88 0.0023 0.019 0.052
Brugia malayi MH2 domain containing protein 0.0144 0.1562 0.4541
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0375 0.5196
Echinococcus granulosus dnaJ subfamily B 0.0448 0.5007 0.5886
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.019 0.0209
Schistosoma mansoni hypothetical protein 0.0045 0.0432 0.0494
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0063
Brugia malayi Nuclear hormone receptor E75 0.0011 0.005 0.0112
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.004 0.0385 0.0373
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.005 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0134 0.2563
Onchocerca volvulus Carboxypeptidase D homolog 0.001 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0385 0.0439
Schistosoma mansoni hypothetical protein 0.0045 0.0432 0.0494
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0034 0.0314
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.001 0.0034 0.0026
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0048 0.0145
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0048 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.1149 0.333
Schistosoma mansoni hypothetical protein 0.0035 0.0317 0.036
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.005 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0026 0.022 0.0609
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0375 0.1283
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.019 0.0209
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0034 0.0064
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.019 0.0209
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.019 0.0178
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0525 0.1502
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0012 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0375 0.5196
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0023 0.019 0.0581
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0231
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.019 0.052
Loa Loa (eye worm) hypothetical protein 0.0033 0.0304 0.0856
Echinococcus granulosus glycoprotein Antigen 5 0.0278 0.3078 0.3612
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0059 0.0591 0.8298
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0155
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0023 0.019 0.2554
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0069 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0304 0.0293
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0056 0.0557 0.1778
Schistosoma mansoni hypothetical protein 0.0035 0.0318 0.0361
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.5007 0.5001
Onchocerca volvulus Netrin receptor homolog 0.0035 0.0318 0.1
Schistosoma mansoni zinc finger protein 0.0011 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0134 0.1448 0.4205
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0105 0.0272
Echinococcus granulosus nuclear factor of activated T cells 5 0.0338 0.3768 0.4426
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.019 0.0209
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.001 0.0034 0.0072
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0048 0.0594
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0308 0.3426 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0282 0.0792
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Onchocerca volvulus 0.0278 0.3078 1
Echinococcus granulosus expressed conserved protein 0.0101 0.1075 0.1252
Loa Loa (eye worm) hypothetical protein 0.0108 0.1149 0.333
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.022 0.0679
Echinococcus multilocularis muscleblind protein 0.0163 0.1781 0.1771
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1164 0.3375
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.022
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.001 0.0034 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.019 0.0579
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0304 0.4844
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0134 0.2563
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Schistosoma mansoni topbp1 0.0011 0.0048 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.019 0.052
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.2863 0.336
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.195 0.2283
Brugia malayi Matrixin family protein 0.0019 0.014 0.0374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0304 0.0344
Echinococcus granulosus FTZ F1 alpha 0.0023 0.019 0.0209
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.019 0.0209
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0391
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0012 0.0231
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0615 1
Brugia malayi hypothetical protein 0.0012 0.0065 0.0155
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Schistosoma mansoni Smad4 0.001 0.0037 0.0029
Brugia malayi hypothetical protein 0.0012 0.0065 0.0155
Onchocerca volvulus 0.003 0.0261 0.0811
Brugia malayi Trypsin family protein 0.0278 0.3078 0.8981
Onchocerca volvulus 0.0103 0.1096 0.3536
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.001 0.0034 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.8499 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0155
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.022 0.0679
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0012 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.019 0.052
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Brugia malayi hypothetical protein 0.0134 0.1448 0.4205
Schistosoma mansoni hypothetical protein 0.0448 0.5007 0.5886
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Loa Loa (eye worm) STAT protein 0.0144 0.156 0.4533
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0728
Trypanosoma brucei prolyl endopeptidase 0.0059 0.0591 0.8298
Onchocerca volvulus 0.0011 0.0048 0.0117
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0317 0.0306
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0037 0.0073
Schistosoma mansoni carboxypeptidase N (M14 family) 0.001 0.0034 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0093 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.022 0.0679
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0375 0.6013
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0048 0.0145
Schistosoma mansoni nuclear hormone receptor 0.0011 0.005 0.0045
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0059 0.0591 0.0682
Trypanosoma brucei glucosidase, putative 0.004 0.0375 0.5196
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Brugia malayi Uncoordinated protein 44 0.0035 0.0318 0.0898
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.195 0.5676
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.019 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0145
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.005 0.0045
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0028 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.019 0.0209
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0093 0.0711
Echinococcus granulosus cytosolic carboxypeptidase 1 0.001 0.0034 0.0026
Mycobacterium tuberculosis Probable peptidase 0.0023 0.019 0.3649
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.019 0.052
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.019 0.052
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0037 0.0025
Echinococcus multilocularis smad 0.001 0.0037 0.0025
Entamoeba histolytica hypothetical protein 0.0011 0.0048 0.0315
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0093 0.1158
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Brugia malayi STAT protein, DNA binding domain containing protein 0.0144 0.156 0.4533
Echinococcus granulosus muscleblind protein 0.0163 0.1781 0.2085
Entamoeba histolytica protein kinase, putative 0.004 0.0385 0.328
Trypanosoma cruzi oligopeptidase b 0.0023 0.019 0.2554
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0048 0.0516
Brugia malayi Smad1 0.001 0.0037 0.0073
Brugia malayi Pre-SET motif family protein 0.0033 0.0304 0.0856
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.019 0.0209
Onchocerca volvulus 0.0023 0.019 0.0579
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.004 0.0385 0.0439
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0048 0.5
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.019 0.0178
Schistosoma mansoni survival motor neuron protein 0.0053 0.0525 0.0604
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.019 0.0178
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0019 0.0136 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.001 0.0034 0.0314
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.045 0.1284
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.001 0.0034 0.0026
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0037 0.0025
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.005 0.0045
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0034 0.0064
Brugia malayi Matrixin family protein 0.0008 0.0014 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.019 0.0209
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.005 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0317 0.036
Brugia malayi Nuclear hormone receptor E75 0.0011 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0006
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Schistosoma mansoni lamin 0.003 0.0261 0.0293
Schistosoma mansoni topbp1 0.0011 0.0048 0.0042
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0304 0.0344
Echinococcus multilocularis glycoprotein Antigen 5 0.0278 0.3078 0.307
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Brugia malayi tailless protein 0.0011 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.022 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0048 0.0105
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.022 0.0679
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0375 0.3191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0069 0.071 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0012 0.0231
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0048 0.0106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Plasmodium vivax hypothetical protein, conserved 0.001 0.0034 0.0751
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0048 0.1722
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.019 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0134 0.2563
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.001 0.0033 0.0642
Brugia malayi Carboxypeptidase A2 precursor 0.001 0.0034 0.0064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0028 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0023 0.019 0.0209
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0046
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0375 0.1062
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.005 0.0112
Echinococcus multilocularis prolyl endopeptidase 0.0059 0.0591 0.058
Brugia malayi nuclear hormone receptor 0.0011 0.005 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0093 0.0301
Brugia malayi intermediate filament protein 0.003 0.0261 0.0728
Echinococcus multilocularis lamin dm0 0.003 0.0261 0.0249
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.022 1
Echinococcus granulosus microtubule associated protein 2 0.0755 0.8499 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.019 0.0209
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Echinococcus multilocularis protein dispatched 1 0.0053 0.0525 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0145
Echinococcus granulosus death domain containing protein 0.0035 0.0318 0.0361
Echinococcus granulosus nibrin 0.0011 0.0048 0.0042
Trypanosoma brucei oligopeptidase b 0.0023 0.019 0.2554
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0391
Echinococcus granulosus cpg binding protein 0.0033 0.0303 0.0342
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0375 0.1283
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0278 0.3078 0.3612
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0317 0.0895
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.005 0.0038
Brugia malayi Trypsin family protein 0.0278 0.3078 0.8981
Schistosoma mansoni cpg binding protein 0.0033 0.0303 0.0342
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0609
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0093 0.0237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0696 0.0806
Schistosoma mansoni hypothetical protein 0.0045 0.0432 0.0494
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0375 0.1062
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.3171
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0048 0.0315
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.3171
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.005 0.0124
Brugia malayi nuclear hormone receptor 0.0023 0.019 0.052
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Echinococcus multilocularis 0.001 0.0034 0.0022
Echinococcus multilocularis protein patched 0.0046 0.045 0.0439
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0338 0.3768 0.3761
Onchocerca volvulus Matrilysin homolog 0.0017 0.0122 0.0359
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0093 0.1158
Brugia malayi conserved hypotetical protein 0.0011 0.005 0.0112
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Echinococcus multilocularis transmembrane protease serine 3 0.0278 0.3078 0.307
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.1149 0.1138
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0065 0.0155
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.005 0.0038
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0037 0.0029
Echinococcus granulosus Ankyrin 0.0035 0.032 0.0363
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0048 0.0105
Schistosoma mansoni ankyrin 23/unc44 0.0035 0.0318 0.0361
Brugia malayi Matrixin family protein 0.0008 0.0014 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0057 0.0569 0.163
Brugia malayi nuclear receptor NHR-67 0.0011 0.005 0.0112
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.307
Brugia malayi Trypsin family protein 0.0278 0.3078 0.8981
Brugia malayi DKFZp564C0469 protein 0.0011 0.0048 0.0105
Brugia malayi hypothetical protein 0.0011 0.0048 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.022 0.4221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.019 0.052
Onchocerca volvulus 0.0011 0.005 0.0124
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0056 0.0557 0.0642
Loa Loa (eye worm) matrix metalloproteinase 0.0008 0.0014 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0048 0.0513
Schistosoma mansoni cpg binding protein 0.0033 0.0303 0.0342
Onchocerca volvulus 0.0278 0.3078 1
Onchocerca volvulus 0.0011 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Loa Loa (eye worm) hypothetical protein 0.0163 0.1781 0.5183
Echinococcus granulosus intermediate filament protein 0.003 0.0261 0.0293
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.022 0.0679
Trypanosoma brucei prolyl oligopeptidase, putative 0.0023 0.019 0.2554
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.019 0.052
Schistosoma mansoni hypothetical protein 0.0045 0.0432 0.0494
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0373 0.0361
Echinococcus multilocularis netrin receptor unc 5 0.0035 0.0318 0.0307
Trypanosoma brucei Carboxypeptidase-like protein 0.001 0.0034 0.0314
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0048 0.0513
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0304 0.0344
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0026
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0231
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.019 0.0579
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Echinococcus multilocularis lamin 0.003 0.0261 0.0249
Schistosoma mansoni alpha glucosidase 0.004 0.0375 0.0427
Onchocerca volvulus 0.0011 0.005 0.0124
Brugia malayi Death domain containing protein 0.0035 0.0318 0.0898
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.005 0.0045
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0034 0.0064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0105 0.0272
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0375 0.1283
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0052 0.0521 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0278 0.3078 0.8981
Schistosoma mansoni protease m14 carboxypeptidase 0.001 0.0034 0.0026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0093 0.0301
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0034 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0283 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.019 0.052
Trichomonas vaginalis set domain proteins, putative 0.026 0.2876 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0006
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0035 0.0318 0.0307
Loa Loa (eye worm) hypothetical protein 0.0163 0.1781 0.5183
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0146 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0391
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.3078 0.3612
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0037 0.0029
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0048 0.0042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.005 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.019 0.052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.019 0.052
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.001 0.0034 0.0364
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0035 0.0318 0.0361
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0278 0.3078 0.3612
Onchocerca volvulus Prolyl endopeptidase homolog 0.0059 0.0591 0.1889
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0155
Entamoeba histolytica protein kinase, putative 0.004 0.0385 0.328
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.8499 0.8497
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0064
Brugia malayi MH1 domain containing protein 0.001 0.0037 0.0073
Toxoplasma gondii flagellar/basal body protein 0.001 0.0034 0.0364
Brugia malayi AMP-binding enzyme family protein 0.0026 0.022 0.0609
Echinococcus multilocularis Ankyrin 0.0035 0.032 0.0308
Schistosoma mansoni hypothetical protein 0.0278 0.3078 0.3612
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.005 0.0045
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0048 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0317 0.0895
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.019 0.0209
Loa Loa (eye worm) hypothetical protein 0.0035 0.032 0.0902
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.195 0.194
Loa Loa (eye worm) hypothetical protein 0.0259 0.2863 0.8352
Schistosoma mansoni hypothetical protein 0.0075 0.0772 0.0896
Brugia malayi Protein kinase domain containing protein 0.0035 0.0328 0.0927
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0146 0.4573
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0048 0.2682
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Loa Loa (eye worm) matrixin family protein 0.0017 0.0122 0.0322
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.001 0.0034 0.0022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0317 0.036
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0093 0.1158
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0028 0.0248 0.0236
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0048 0.1226
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0048 0.0513
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1562 0.4541
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0261 0.0728
Brugia malayi nuclear receptor RXR 0.0012 0.0065 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.019 0.052
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.195 0.194
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.022 0.183
Schistosoma mansoni cpg binding protein 0.0031 0.0282 0.0319
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.1674 0.1958
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.019 0.0178
Echinococcus multilocularis cpg binding protein 0.0033 0.0303 0.0291
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0093 0.0301
Echinococcus granulosus transmembrane protease serine 3 0.0278 0.3078 0.3612
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1562 0.4541
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0034 0.0096
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0231
Echinococcus granulosus lamin dm0 0.003 0.0261 0.0293
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0375 0.1283
Brugia malayi Pre-SET motif family protein 0.0228 0.2519 0.7344
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0317 0.036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0237
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.004 0.0385 0.0373
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0034 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0304 0.0344
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0023 0.019 0.2554
Schistosoma mansoni cercarial elastase (S01 family) 0.0278 0.3078 0.3612
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.019 0.0209
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.022 0.2981
Onchocerca volvulus 0.0278 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.019 0.052
Loa Loa (eye worm) hypothetical protein 0.0134 0.1448 0.4205
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0112
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.022 0.4221
Schistosoma mansoni hypothetical protein 0.0278 0.3078 0.3612
Loa Loa (eye worm) hypothetical protein 0.0278 0.3078 0.8981
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0318 0.0898
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.019 0.0209
Brugia malayi Matrixin family protein 0.0008 0.0014 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.045 0.0439
Loa Loa (eye worm) trypsin family protein 0.0278 0.3078 0.8981
Onchocerca volvulus Huntingtin homolog 0.0134 0.1448 0.4682
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.005 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.019 0.052
Schistosoma mansoni patched 1 0.0046 0.045 0.0517
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0035 0.0318 0.0898
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0304 0.0293
Echinococcus granulosus Smad4 0.001 0.0037 0.0029
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0375 0.1283
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0065 0.0155
Onchocerca volvulus 0.0026 0.022 0.0679
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.1674 0.1664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.019 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0772 0.2227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0016
Onchocerca volvulus 0.0278 0.3078 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0023 0.019 0.3649
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0012 0.0231
Schistosoma mansoni lamin 0.003 0.0261 0.0293
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0048 0.0117
Onchocerca volvulus Matrix metalloproteinase homolog 0.0017 0.0122 0.0359
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2519 0.7344
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.019 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.019 0.052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.005 0.0045
Brugia malayi Trypsin-like protease protein 5 0.0278 0.3078 0.8981
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0146 0.0436
Brugia malayi hypothetical protein 0.0011 0.0048 0.0105

Activities

Activity type Activity value Assay description Source Reference
EC50 > 6.188 um PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1321, AID1410, AID1412, AID1413, AID1414, AID1807, AID434972] Panel member name: Wee1 Degradation ChEMBL. No reference
EC50 > 55.69 um PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1321, AID1410, AID1412, AID1413, AID1414, AID1807, AID434972] Panel member name: Cyclin B Degradation ChEMBL. No reference
IC50 (functional) 2.971 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 8.229 uM PubChem BioAssay. Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.