Detailed information for compound 1519053

Basic information

Technical information
  • TDR Targets ID: 1519053
  • Name: N-(2,4-dimethoxyphenyl)-2-[4-(4-methoxyphenyl )sulfonyl-1,4-diazepan-1-yl]acetamide
  • MW: 463.547 | Formula: C22H29N3O6S
  • H donors: 1 H acceptors: 3 LogP: 2.06 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)N1CCCN(CC1)CC(=O)Nc1ccc(cc1OC)OC
  • InChi: 1S/C22H29N3O6S/c1-29-17-5-8-19(9-6-17)32(27,28)25-12-4-11-24(13-14-25)16-22(26)23-20-10-7-18(30-2)15-21(20)31-3/h5-10,15H,4,11-14,16H2,1-3H3,(H,23,26)
  • InChiKey: BZBRXUIARJBUIN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-2-[4-(4-methoxyphenyl)sulfonyl-1,4-diazepan-1-yl]ethanamide
  • EU-0053840
  • NCGC00165075-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0043 0.0138
Brugia malayi probable protein kinase 0.0176 0.1491 0.4771
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0059 0.0457 0.1461
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0398 0.1274
Schistosoma mansoni protein kinase 0.0176 0.1491 0.1491
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1208 0.3864
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0086
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0027 0.0027
Schistosoma mansoni loxhd1 0.0201 0.1713 0.1713
Schistosoma mansoni cell adhesion molecule 0.0013 0.0049 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0319 0.0319
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0175 0.1477 0.1477
Onchocerca volvulus 0.0017 0.0085 0.02
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.004 0.0129
Onchocerca volvulus Peroxidasin homolog 0.0058 0.0448 0.1459
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.043 0.359
Schistosoma mansoni ferritin light chain 0.0008 0.0009 0.0009
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0085 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0027 0.0027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0078 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0142 0.0492
Schistosoma mansoni rap gtpase-activating protein 0.0052 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Entamoeba histolytica hypothetical protein, conserved 0.0315 0.2713 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0043 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0086
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0043 0.0382
Echinococcus granulosus defective proboscis extension response 0.0022 0.0131 0.0131
Leishmania major trypanothione reductase 0.0047 0.0348 0.3077
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0142 0.1367
Loa Loa (eye worm) TK protein kinase 0.0008 0.0003 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0348 0.1254
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0043 0.0382
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Echinococcus granulosus protein kinase 0.0125 0.1035 0.1035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0983 0.36
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0142 0.0492
Trypanosoma brucei trypanothione reductase 0.0047 0.0348 0.3077
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0136 0.1132 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0201 0.1713 1
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0136 0.1132 0.6518
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0043 0.0043
Onchocerca volvulus 0.0052 0.0391 0.1261
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0448 0.1434
Schistosoma mansoni peroxidasin 0.0052 0.0398 0.0398
Brugia malayi Protein kinase domain containing protein 0.0053 0.0405 0.1296
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0186 0.1581 0.1581
Schistosoma mansoni nephrin 0.0028 0.0182 0.0182
Schistosoma mansoni ferritin light chain 0.0008 0.0009 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0027 0.0086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0142 0.0492
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0085 0.0085
Schistosoma mansoni lipoxygenase 0.0778 0.68 0.68
Brugia malayi ecdysteroid receptor 0.001 0.0027 0.0086
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0078 0.0457
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0022 0.0022
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0165 0.1393 0.4458
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0049 0.0049
Schistosoma mansoni cell adhesion molecule 0.0029 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0455
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0086
Schistosoma mansoni rab6-interacting 0.0201 0.1713 0.1713
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0398 0.1285
Brugia malayi Protein kinase domain containing protein 0.0165 0.1393 0.4458
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0142 0.0455
Brugia malayi diacylglycerol kinase 0.0012 0.0043 0.0138
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.007
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0078 0.1134
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0043 0.0057
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0043 0.0043
Echinococcus multilocularis neuroglian 0.0013 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0043
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0391 0.3457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Echinococcus granulosus ceramide kinase 0.0012 0.0043 0.0043
Schistosoma mansoni Smad4 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0142 0.0524
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0085 0.0708
Echinococcus granulosus peroxidasin 0.0065 0.0512 0.0512
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0078 0.0256
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0877 0.3211
Echinococcus granulosus protein jagged 2 0.0017 0.0085 0.0085
Echinococcus granulosus delta-like protein 1 0.0017 0.0085 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0027 0.0086
Echinococcus multilocularis notch 0.0017 0.0085 0.0085
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0052 0.0391 0.0391
Plasmodium falciparum glutathione reductase 0.0016 0.0078 0.0457
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0398 0.1274
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Trichomonas vaginalis ferritin, putative 0.0008 0.0009 0.0076
Plasmodium falciparum LCCL domain-containing protein 0.0201 0.1713 1
Onchocerca volvulus 0.0017 0.0085 0.02
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0983 0.36
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0081 0.0267
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0053 0.0405 0.0405
Entamoeba histolytica cdc48-like protein, putative 0.0136 0.1132 0.4171
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0304 0.0304
Schistosoma mansoni peroxidasin 0.006 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0625
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0059 0.0457 0.0457
Loa Loa (eye worm) glutathione reductase 0.0047 0.0348 0.1114
Loa Loa (eye worm) hypothetical protein 0.0201 0.1713 0.548
Echinococcus granulosus lipoxygenase domain containing protein 0.0201 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0973
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0078 0.0256
Echinococcus granulosus smad 0.001 0.0022 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0086
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0361 0.3126 1
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0043 0.0043
Echinococcus multilocularis protein jagged 1 0.0017 0.0085 0.0085
Toxoplasma gondii cell division protein CDC48CY 0.0143 0.1196 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0877 0.3211
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0043 0.0362
Brugia malayi Temporarily assigned gene name protein 59 0.0052 0.0391 0.1251
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0043 0.0382
Giardia lamblia AAA family ATPase 0.0086 0.069 1
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0143 0.1196 1
Brugia malayi Muscle positioning protein 4 0.0017 0.0085 0.0271
Schistosoma mansoni ferritin 0.0008 0.0009 0.0009
Echinococcus granulosus roundabout 2 0.0035 0.0246 0.0246
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0085 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0027 0.0027
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0143 0.1196 0.1196
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Echinococcus granulosus tyrosine protein kinase otk 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0455
Plasmodium falciparum thioredoxin reductase 0.0047 0.0348 0.2033
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0085 0.0085
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0142 0.1257
Schistosoma mansoni hypothetical protein 0.0043 0.0319 0.0319
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0391 0.3457
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0049 0.0157
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0085 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0086
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0391 0.0391
Schistosoma mansoni polycystin 1-related 0.0201 0.1713 0.1713
Echinococcus granulosus RUN 0.0201 0.1713 0.1713
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0142 0.1367
Brugia malayi glutathione reductase 0.0047 0.0348 0.1114
Brugia malayi hypothetical protein 0.0052 0.0391 0.1251
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0043 0.0382
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.004 0.0129
Schistosoma mansoni apoferritin-2 0.0008 0.0009 0.0009
Mycobacterium tuberculosis Probable reductase 0.0107 0.0877 0.3211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Brugia malayi Prion-like- 0.0013 0.0049 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Schistosoma mansoni cpg binding protein 0.0031 0.0211 0.0211
Schistosoma mansoni ferritin 0.0008 0.0009 0.0009
Onchocerca volvulus 0.0052 0.0398 0.1285
Echinococcus granulosus contactin 0.0013 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0027 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Brugia malayi map kinase activated protein kinase protein 2 0.0186 0.1581 0.5059
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0043 0.0043
Trypanosoma cruzi Valosin-containing protein, putative 0.0136 0.1132 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0142 0.0524
Echinococcus multilocularis smad 0.001 0.0022 0.0022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0142 0.0492
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0085 0.0271
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0877 0.3211
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Onchocerca volvulus Peroxidase homolog 0.0052 0.0398 0.1285
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.0287
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0086 0.069 0.5767
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0043 0.0319 0.1174
Brugia malayi hypothetical protein 0.0201 0.1713 0.548
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0795 0.2931
Schistosoma mansoni hypothetical protein 0.0201 0.1713 0.1713
Echinococcus multilocularis RUN 0.0201 0.1713 0.1713
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0015 0.0047
Schistosoma mansoni nephrin 0.0013 0.0049 0.0049
Toxoplasma gondii cell division protein CDC48AP 0.0086 0.069 0.5767
Onchocerca volvulus Peroxidasin homolog 0.0058 0.0448 0.1459
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0348 0.3077
Echinococcus multilocularis cpg binding protein 0.0031 0.0211 0.0211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Mycobacterium ulcerans hypothetical protein 0.0023 0.0142 0.0492
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.007
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0085 0.0085
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0983 0.36
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0086
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Echinococcus granulosus protein jagged 2 0.0017 0.0085 0.0085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0022 0.007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0078 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0078 0.0256
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0043 0.0382
Echinococcus multilocularis microtubule associated protein 2 0.071 0.6207 0.6207
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0027 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0405 0.0405
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0165 0.1393 0.4458
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0027 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0053 0.0405 0.0405
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0078 0.0691
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0078 0.0691
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0013 0.0049 0.0049
Echinococcus granulosus hemicentin 1 0.0013 0.0049 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0027 0.0027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0877 0.3211
Echinococcus granulosus Immunoglobulin 0.0022 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0043 0.0319 0.1174
Trichomonas vaginalis bmru protein, putative 0.0012 0.0043 0.0362
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1208 0.3864
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0131 0.0131
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Schistosoma mansoni ferritin 0.0008 0.0009 0.0009
Echinococcus multilocularis lipoxygenase domain containing protein 0.0201 0.1713 0.1713
Echinococcus granulosus Smad4 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Echinococcus multilocularis fibropellin Ia 0.0017 0.0085 0.0085
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0013 0.0049 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.0287
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0034 0.0233 0.195
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0078 0.0209
Loa Loa (eye worm) notch protein 0.0017 0.0085 0.0271
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Treponema pallidum NADH oxidase 0.0016 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni cpg binding protein 0.003 0.0196 0.0196
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.009 0.0524
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0085 0.0271
Brugia malayi nuclear hormone receptor 0.001 0.0027 0.0086
Echinococcus multilocularis Immunoglobulin 0.0022 0.0131 0.0131
Schistosoma mansoni lipoxygenase 0.114 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0142 0.0492
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0022
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0391 0.0391
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0165 0.1393 0.1393
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0043 0.0043
Brugia malayi Smad1 0.001 0.0022 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0795 0.0795
Brugia malayi MH2 domain containing protein 0.0144 0.1208 0.3864
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0398 0.1274
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0348 0.1114
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0348 0.0348
Trypanosoma brucei Valosin-containing protein 0.0136 0.1132 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0027 0.0027
Brugia malayi hypothetical protein 0.0022 0.0131 0.042
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0052 0.0391 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0086
Echinococcus multilocularis roundabout 2 0.0013 0.0049 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0081 0.0267
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0043 0.0138
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0027 0.0027
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0085 0.0271
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0078 0.0691
Schistosoma mansoni cell adhesion molecule 0.0013 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0043 0.0319 0.1174
Mycobacterium ulcerans ATPase 0.0086 0.069 0.2518
Mycobacterium tuberculosis Conserved protein 0.0315 0.2713 1
Schistosoma mansoni patched 1 0.0042 0.0304 0.0304
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0125 0.1035 0.3312
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0078 0.0691
Onchocerca volvulus 0.0017 0.0085 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0691
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0043 0.0382
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Plasmodium vivax glutathione reductase, putative 0.0047 0.0348 0.1826
Brugia malayi Blistered cuticle protein 3 0.0052 0.0398 0.1274
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0489 0.0489
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0059 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0052 0.0391 0.1251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Schistosoma mansoni hypothetical protein 0.0421 0.3652 0.3652
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0027 0.0086
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0085 0.0085
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0043 0.0362
Schistosoma mansoni roundabout 0.0013 0.0049 0.0049
Echinococcus granulosus FTZ F1 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0138
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0304 0.0304
Mycobacterium ulcerans hypothetical protein 0.0315 0.2713 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Onchocerca volvulus Peroxidase homolog 0.0052 0.0398 0.1285
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0078 0.0209
Loa Loa (eye worm) TK/ROR protein kinase 0.0008 0.0003 0.001
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0085 0.0085
Echinococcus multilocularis protein jagged 1 0.0017 0.0085 0.0085
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Schistosoma mansoni sphingoid long chain base kinase 0.0315 0.2713 0.2713
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0043 0.0043
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0043 0.0362
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0983 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0398 0.1274
Echinococcus granulosus lachesin 0.0013 0.0049 0.0049
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0031 0.0211 0.0211
Onchocerca volvulus 0.0023 0.0142 0.0399
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0043 0.0382
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0022 0.0131 0.0131
Schistosoma mansoni coup transcription factor 0.001 0.0027 0.0027
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0398 0.1285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Echinococcus multilocularis expressed protein 0.0008 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0201 0.1713 0.548
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0013 0.0049 0.0049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0138
Schistosoma mansoni sphingosine kinase A B 0.0315 0.2713 0.2713
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0078 0.0654
Echinococcus multilocularis peroxidasin 0.0065 0.0512 0.0512
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0086
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0085 0.0271
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.0287
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0078 0.0654
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.0287
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.114 1 1
Brugia malayi hypothetical protein 0.0043 0.0319 0.1019
Schistosoma mansoni ferritin 0.0008 0.0009 0.0009
Brugia malayi CXXC zinc finger family protein 0.003 0.0196 0.0627
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0043 0.0362
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0142 0.0492
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Entamoeba histolytica hypothetical protein 0.0043 0.0319 0.1174
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0078 0.0654
Echinococcus multilocularis ceramide kinase 0.0012 0.0043 0.0043
Onchocerca volvulus Putative cubilin 0.0017 0.0085 0.02
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0086
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0043 0.0138
Leishmania major hypothetical protein, conserved 0.0012 0.0043 0.0382
Brugia malayi valosin containing protein 0.0084 0.0675 0.2159
Onchocerca volvulus 0.0052 0.0398 0.1285
Echinococcus granulosus Vam6:Vps39 protein 0.0052 0.0391 0.0391
Brugia malayi follicle stimulating hormone receptor 0.0243 0.2082 0.666
Trichomonas vaginalis bmru protein, putative 0.0012 0.0043 0.0362
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0165 0.1393 0.473
Brugia malayi Fibronectin type III domain containing protein 0.0022 0.0131 0.042
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0053 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0052 0.0391 0.0391
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0043 0.0043
Plasmodium falciparum thioredoxin reductase 0.0016 0.0078 0.0457
Echinococcus granulosus microtubule associated protein 2 0.071 0.6207 0.6207
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0691
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.2082 0.666
Loa Loa (eye worm) hypothetical protein 0.0065 0.0512 0.1639
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0142 0.1257
Schistosoma mansoni septate junction protein 0.0013 0.0049 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Echinococcus multilocularis roundabout 2 0.0013 0.0049 0.0049
Echinococcus granulosus ferritin 0.0008 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0086
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0078 0.0457
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0142 0.1257
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0078 0.0654
Echinococcus granulosus roundabout 2 0.0013 0.0049 0.0049
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.0448 0.1434
Schistosoma mansoni tyrosine kinase 0.0015 0.0067 0.0067
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.3652 0.3652
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.009 0.0287
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0319 0.0319
Loa Loa (eye worm) ceramide kinase 0.0012 0.0043 0.0138
Schistosoma mansoni vam6/vps39 related 0.0052 0.0391 0.0391
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0196 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0086
Schistosoma mansoni titin 0.0013 0.0049 0.0049
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0013 0.0049 0.0049
Loa Loa (eye worm) Notch2 0.0017 0.0085 0.0271
Loa Loa (eye worm) hypothetical protein 0.0052 0.0391 0.1251
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0348 0.0348
Echinococcus multilocularis Smad4 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0013 0.0049 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0246 0.0786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Onchocerca volvulus 0.0017 0.0085 0.02
Schistosoma mansoni smad 0.001 0.0022 0.0022
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0013 0.0049 0.0049
Echinococcus multilocularis neuroglian 0.0028 0.0182 0.0182
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0391 0.1251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0043 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0246 0.0786
Brugia malayi EGF-like domain containing protein 0.0017 0.0085 0.0271
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0256
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0143 0.1196 0.1196
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0086
Echinococcus multilocularis lipoxygenase domain containing protein 0.0201 0.1713 0.1713
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0398 0.1274
Brugia malayi Doublecortin family protein 0.0201 0.1713 0.548
Echinococcus multilocularis neural cadherin 0.0017 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0304 0.2542
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0085 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1393 0.1393
Schistosoma mansoni protein kinase 0.0125 0.1035 0.1035
Loa Loa (eye worm) doublecortin family protein 0.0201 0.1713 0.548
Echinococcus granulosus expressed conserved protein 0.0092 0.0743 0.0743
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0027 0.0027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0015 0.0063 0.0202
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0877 0.3211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0086
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0043 0.0382
Echinococcus multilocularis lachesin 0.0013 0.0049 0.0049
Brugia malayi Thioredoxin reductase 0.0047 0.0348 0.1114
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0043 0.0126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0043 0.0362
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Brugia malayi notch-like transmembrane receptor 0.0017 0.0085 0.0271
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0027 0.0027
Echinococcus multilocularis protein dispatched 1 0.0048 0.0356 0.0356
Echinococcus multilocularis tyrosine protein kinase otk 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0008 0.0003 0.0003
Brugia malayi Delta serrate ligand family protein 0.0017 0.0085 0.0271
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0008 0.0003 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0361 0.3126 1
Mycobacterium tuberculosis Putative conserved ATPase 0.0086 0.069 0.2518
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Brugia malayi nuclear receptor NHR-88 0.001 0.0027 0.0086
Brugia malayi vesicle-fusing ATPase 0.0084 0.0675 0.2159
Echinococcus granulosus cpg binding protein 0.0031 0.0211 0.0211
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.009 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0043 0.0362
Loa Loa (eye worm) hypothetical protein 0.0051 0.0387 0.1239
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni septate junction protein 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0138
Brugia malayi Ceramide kinase 0.0012 0.0043 0.0138
Onchocerca volvulus 0.0201 0.1713 0.5837
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0398 0.1274
Echinococcus multilocularis Immunoglobulin 0.0022 0.0131 0.0131
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0085 0.0085
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.009 0.0298
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0085 0.0271
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0022 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.071 0.6207 0.6207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0136 0.1132 0.6606
Loa Loa (eye worm) hypothetical protein 0.0175 0.1477 0.4726
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0136 0.1132 0.1132
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0034 0.0233 0.195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Leishmania major diacylglycerol kinase, putative 0.0012 0.0043 0.0382
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0165 0.1393 0.1393
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0142 0.0492
Echinococcus granulosus twitchin 0.003 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Echinococcus granulosus neuroglian 0.0028 0.0182 0.0182
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0398 0.1274
Loa Loa (eye worm) VCP protein 0.0059 0.0457 0.1461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0319 0.0319
Schistosoma mansoni slit 0.0017 0.0085 0.0085
Echinococcus granulosus neural cadherin 0.0017 0.0085 0.0085
Brugia malayi hypothetical protein 0.0012 0.0043 0.0138
Schistosoma mansoni neuroglian 0.0013 0.0049 0.0049
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0143 0.1196 0.4049
Brugia malayi steroid hormone receptor 0.001 0.0027 0.0086
Brugia malayi hypothetical protein 0.0201 0.1713 0.548
Schistosoma mansoni cell polarity protein 0.0017 0.0085 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0877 0.892
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Echinococcus granulosus protein jagged 1 0.0017 0.0085 0.0085
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0043 0.0362
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0053 0.0405 0.1296
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Echinococcus granulosus Polycystic kidney disease protein 0.0201 0.1713 0.1713
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0043 0.0382
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0043 0.0382
Echinococcus multilocularis roundabout 2 0.0035 0.0246 0.0246
Loa Loa (eye worm) vesicle-fusing ATPase 0.0084 0.0675 0.2159
Echinococcus multilocularis 0.0125 0.1035 0.1035
Echinococcus multilocularis expressed conserved protein 0.0092 0.0743 0.0743
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0085 0.02
Echinococcus multilocularis sphingosine kinase 1 0.0315 0.2713 0.2713
Onchocerca volvulus 0.003 0.0196 0.0586
Echinococcus multilocularis protein jagged 2 0.0017 0.0085 0.0085
Toxoplasma gondii thioredoxin reductase 0.0047 0.0348 0.291
Brugia malayi hypothetical protein 0.0052 0.0398 0.1274
Echinococcus multilocularis hemicentin 1 0.0013 0.0049 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0142 0.0524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0348 0.1826
Echinococcus granulosus sphingosine kinase 1 0.0315 0.2713 0.2713
Brugia malayi Cadherin domain containing protein 0.0017 0.0085 0.0271
Plasmodium vivax cell division cycle ATPase, putative 0.0052 0.0392 0.2087
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1164 0.1164
Schistosoma mansoni apoferritin-2 0.0008 0.0009 0.0009
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0795 0.0795
Onchocerca volvulus 0.0201 0.1713 0.5837
Echinococcus multilocularis Polycystic kidney disease protein 0.0201 0.1713 0.1713
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0043 0.0126
Onchocerca volvulus 0.0052 0.0398 0.1285
Loa Loa (eye worm) hypothetical protein 0.0084 0.0675 0.2159
Giardia lamblia High cysteine protein 0.0017 0.0085 0.1227
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0016 0.0051
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0391 0.3457
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0691
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.0405 0.0405
Echinococcus granulosus roundabout 2 0.0013 0.0049 0.0049
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0043 0.0362
Loa Loa (eye worm) hypothetical protein 0.0315 0.2713 0.868
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0043 0.0253
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0022 0.007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Schistosoma mansoni notch 0.0017 0.0085 0.0085
Echinococcus granulosus slit 2 protein 0.0017 0.0085 0.0085
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.009 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0081 0.0267
Echinococcus multilocularis ferritin 0.0008 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1164 0.1164
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0022 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0131 0.042
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0795 0.2544
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0143 0.1196 0.1196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0142 0.0492
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0043 0.0253
Loa Loa (eye worm) Smad1 0.001 0.0022 0.007
Brugia malayi Peroxidasin 0.0065 0.0512 0.1639
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0131 0.042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0304 0.0304
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0027 0.0027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0691
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) hypothetical protein 0.0097 0.0795 0.2544
Onchocerca volvulus Tyrosine kinase homolog 0.0338 0.2916 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0022 0.0022
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0165 0.1393 0.4458
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0053 0.0405 0.0405
Schistosoma mansoni protein kinase 0.0053 0.0405 0.0405
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0078 0.025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Echinococcus granulosus expressed protein 0.0008 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1581 0.1581
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0142 0.0455
Echinococcus granulosus dnaJ subfamily B 0.0421 0.3652 0.3652
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0052 0.0398 0.1274
Schistosoma mansoni vesicular amine transporter 0.0022 0.0131 0.0131
Echinococcus granulosus fibropellin Ia 0.0017 0.0085 0.0085
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0043 0.0362
Schistosoma mansoni hypothetical protein 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Onchocerca volvulus 0.0017 0.0085 0.02
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.007
Onchocerca volvulus 0.0012 0.0043 0.0057
Echinococcus granulosus protein jagged 1 0.0017 0.0085 0.0085
Brugia malayi CHE-14 protein 0.0042 0.0304 0.0973
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Echinococcus granulosus neuroglian 0.0013 0.0049 0.0049
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0012 0.0043 0.0382
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0078 1
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0085 0.0085
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.009 0.0279
Echinococcus multilocularis protein patched 0.0042 0.0304 0.0304
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Schistosoma mansoni nuclear hormone receptor 0.001 0.0027 0.0027
Plasmodium falciparum glutathione reductase 0.0047 0.0348 0.2033
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0398 0.1274
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0043 0.0382
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0142 0.0455
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0455
Schistosoma mansoni rab6-interacting 0.0201 0.1713 0.1713
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0691
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0086
Brugia malayi diacylglycerol kinase 0.0012 0.0043 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0142 0.0492
Schistosoma mansoni cell adhesion molecule 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0013 0.0049 0.0049
Onchocerca volvulus 0.033 0.2848 0.9765
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0043 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0304 0.0973
Onchocerca volvulus Slit protein homolog 0.0017 0.0085 0.02
Brugia malayi Cadherin domain containing protein 0.0017 0.0085 0.0271
Echinococcus multilocularis slit 2 protein 0.0017 0.0085 0.0085
Schistosoma mansoni septate junction protein 0.0017 0.0085 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0049 0.0157
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0043 0.0382
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0029 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0271
Echinococcus granulosus notch 0.0017 0.0085 0.0085
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0049 0.0157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0027 0.0027
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0043 0.0362
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0136 0.1132 0.4171
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0085 0.0085
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0809 0.0809
Echinococcus multilocularis hemicentin 1 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0157
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0186 0.1581 0.5059
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0405 0.0405
Echinococcus granulosus lipoxygenase domain containing protein 0.0201 0.1713 0.1713
Trypanosoma brucei Sphingosine kinase 0.0012 0.0043 0.0382
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0003 0.001
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0186 0.1581 0.1581
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0081 0.0267
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0043 0.0382

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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