Detailed information for compound 1554537

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.358 | Formula: C20H19BrN4O4S
  • H donors: 0 H acceptors: 4 LogP: 1.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)S(=O)(=O)c1ccccc1Br)Cn1c(=O)cnc2c1cccc2
  • InChi: 1S/C20H19BrN4O4S/c21-15-5-1-4-8-18(15)30(28,29)24-11-9-23(10-12-24)20(27)14-25-17-7-3-2-6-16(17)22-13-19(25)26/h1-8,13H,9-12,14H2
  • InChiKey: XWUCQRPRIWJOAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0041 0.0306 0.0523
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0713 0.8582 1
Plasmodium falciparum glutathione reductase 0.0055 0.0481 0.1228
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0282 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0074 0.0156
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.011 0.0158
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0385 0.038
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0127 0.0123
Schistosoma mansoni ap endonuclease 0.0022 0.0074 0.0069
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0171 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0363 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0244 0.0417
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0074 0.0118
Echinococcus granulosus SAM and MBT domain containing protein 0.0113 0.1191 0.1187
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0337 0.3959 0.461
Trypanosoma cruzi ISWI complex protein 0.0018 0.0024 0.0022
Schistosoma mansoni pyruvate kinase 0.0039 0.0282 0.0277
Brugia malayi jmjC domain containing protein 0.003 0.0171 0.0293
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0244 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0285 0.0634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0181 0.2038 0.2034
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0282 0.0626
Loa Loa (eye worm) TK/ALK protein kinase 0.0019 0.0035 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0595 0.0688
Brugia malayi SEA domain containing protein 0.0017 0.0019 0.0032
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.011 0.0188
Trypanosoma brucei PAB1-binding protein , putative 0.0059 0.0538 0.0621
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.0673 0.0668
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0527
Loa Loa (eye worm) hypothetical protein 0.0034 0.0222 0.0371
Echinococcus granulosus dna polymerase kappa 0.0138 0.1506 0.1502
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.0993 0.1697
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0052
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0673 0.0668
Loa Loa (eye worm) hypothetical protein 0.009 0.0916 0.1559
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0363 0.0925
Loa Loa (eye worm) hypothetical protein 0.0096 0.0993 0.169
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0108 0.0177
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0334 0.0329
Brugia malayi Pre-SET motif family protein 0.007 0.0673 0.1149
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0139 0.0157
Brugia malayi ImpB/MucB/SamB family protein 0.0107 0.1126 0.1924
Loa Loa (eye worm) hypothetical protein 0.0045 0.0353 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0459 0.0454
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.003
Echinococcus multilocularis pyruvate kinase 0.002 0.005 0.0045
Schistosoma mansoni zinc finger protein 0.0027 0.0136 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0559 0.6689 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0215 0.1597
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0282 0.0481
Onchocerca volvulus 0.0017 0.0019 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0673 0.151
Schistosoma mansoni hypothetical protein 0.0689 0.8286 0.8285
Giardia lamblia DINP protein human, muc B family 0.0115 0.122 0.2892
Brugia malayi ecdysone receptor 0.0017 0.0012 0.0021
Onchocerca volvulus 0.0113 0.1191 0.1775
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1518 0.3421
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0282 0.0414
Echinococcus granulosus pyruvate kinase 0.002 0.005 0.0045
Brugia malayi conserved hypotetical protein 0.0017 0.0012 0.0021
Echinococcus granulosus bloom syndrome protein 0.0025 0.011 0.0105
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1358 0.3286
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0485 0.056
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0334 0.0329
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0074 0.0156
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0005 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0012 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0244 0.0417
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0673 0.0779
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0334 0.0329
Echinococcus multilocularis phd:f box containing protein 0.003 0.0171 0.0167
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0222 0.0371
Mycobacterium ulcerans hypothetical protein 0.0055 0.0485 0.1086
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0331 0.3882 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0035
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0244 0.024
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0199 0.0194
Loa Loa (eye worm) mbt repeat family protein 0.0113 0.1191 0.2029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0485 0.1238
Leishmania major hypothetical protein, conserved 0.0059 0.0538 0.0621
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0244 0.024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0039 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1358 0.2025
Echinococcus granulosus pyruvate kinase 0.0039 0.0282 0.0277
Onchocerca volvulus 0.0036 0.0244 0.0358
Echinococcus granulosus chromobox protein 1 0.0081 0.0801 0.0796
Brugia malayi Thioredoxin reductase 0.0055 0.0481 0.0821
Brugia malayi PHD-finger family protein 0.0034 0.0222 0.0379
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1358 0.323
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0485 0.0828
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0673 0.151
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0096 0.0988 0.0984
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1358 0.3286
Trichomonas vaginalis rotamase, putative 0.0039 0.0282 0.0415
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0215 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0244 0.0417
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0485 0.1238
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.01 0.1039 0.1206
Onchocerca volvulus 0.0017 0.0012 0.0011
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.0993 0.0989
Brugia malayi hypothetical protein 0.0059 0.0538 0.0919
Brugia malayi nuclear receptor NHR-88 0.0036 0.0244 0.0417
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0334 0.0329
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0337 0.3959 0.461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0709 0.0704
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0012 0.0008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0005 0.0008
Giardia lamblia Fructose-bisphosphate aldolase 0.0351 0.4123 1
Echinococcus granulosus pyruvate kinase 0.002 0.005 0.0045
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0039 0.0078
Schistosoma mansoni sex comb on midleg homolog 0.0113 0.1191 0.1187
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0171 0.0167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0039 0.004
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0123 0.1322 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0139 0.1021
Brugia malayi hypothetical protein 0.0019 0.0037 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0005 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0542 0.0925
Schistosoma mansoni sex comb on midleg homolog 0.0113 0.1191 0.1187
Plasmodium falciparum pyruvate kinase 2 0.002 0.005 0.0116
Echinococcus multilocularis pyruvate kinase 0.0039 0.0282 0.0277
Brugia malayi nuclear hormone receptor 0.0036 0.0244 0.0417
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.1206 0.2053
Echinococcus granulosus GPCR family 2 0.0019 0.0038 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.0538 0.1374
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0334 0.0721
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0225 0.0567
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0334 0.0798
Schistosoma mansoni microtubule-associated protein tau 0.0828 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0055 0.0485 0.1166
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0139 0.0304
Trypanosoma brucei unspecified product 0.0074 0.0716 0.0829
Echinococcus multilocularis zinc finger protein 0.0027 0.0136 0.0131
Echinococcus multilocularis microtubule associated protein 2 0.0828 1 1
Schistosoma mansoni apoptosis regulator bax 0.0096 0.0988 0.0984
Brugia malayi Protein kinase domain containing protein 0.0019 0.0035 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0244 0.0409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0068 0.0641 0.0636
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0046 0.0041
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0171 0.0167
Schistosoma mansoni bromodomain containing protein 0.0078 0.076 0.0756
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0039 0.004
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0271 0.0647
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1346 0.3033
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0037 0.0032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.122 0.1417
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0485 0.056
Echinococcus granulosus peregrin 0.0041 0.0306 0.0302
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0037 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0244 0.0417
Brugia malayi 6-phosphofructokinase 0.0126 0.1358 0.232
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0225 0.0567
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0139 0.0347
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0244 0.024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0375 0.4428 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0331 0.3882 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1383 0.2357
Entamoeba histolytica deoxycytidyl transferase, putative 0.0107 0.1126 0.2723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0055 0.0485 0.1086
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0171 0.0285
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0709 0.0704
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0039 0.004
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0673 0.5071
Brugia malayi nuclear receptor NHR-88 0.0017 0.0012 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0037 0.0063
Echinococcus granulosus geminin 0.0197 0.2226 0.2222
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0916 0.0912
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0481 0.0814
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0037 0.0032
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1358 0.306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.1506 0.175
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0074 0.0081
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0038 0.0033
Schistosoma mansoni hypothetical protein 0.0197 0.2226 0.2222
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1518 0.3903
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1358 0.1354
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1346 0.3033
Plasmodium falciparum pyruvate kinase 0.0039 0.0282 0.0714
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0012 0.0021
Brugia malayi nuclear receptor RXR 0.0017 0.0012 0.0021
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0171 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0244 0.024
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0334 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0485 0.056
Trichomonas vaginalis DNA polymerase eta, putative 0.0138 0.1506 0.2246
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0222 0.1647
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0171 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Schistosoma mansoni chromobox protein 0.0081 0.0801 0.0796
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0485 0.1086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0313 0.0697
Leishmania major DNA polymerase kappa, putative 0.0033 0.0215 0.0245
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0055 0.0485 0.1086
Loa Loa (eye worm) hypothetical protein 0.0041 0.0309 0.052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0244 0.0417
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.0538 0.0621
Loa Loa (eye worm) hypothetical protein 0.0039 0.0282 0.0474
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0012 0.0021
Onchocerca volvulus 0.0084 0.0836 0.1243
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0039 0.004
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0039 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0485 0.1086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0459 0.0454
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0038 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0485 0.1166
Loa Loa (eye worm) DOMON domain-containing protein 0.0017 0.0019 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0244 0.024
Plasmodium vivax ataxin-2 like protein, putative 0.0059 0.0538 0.1374
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0481 0.0476
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0197 0.2226 0.2222
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0049 0.0044
Trypanosoma brucei trypanothione reductase 0.0055 0.0481 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0282 0.0415
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0011 0.0017
Echinococcus granulosus phd:f box containing protein 0.003 0.0171 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0057
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0012 0.0008
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1358 0.1578
Toxoplasma gondii exonuclease III APE 0.0022 0.0074 0.0525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0334 0.0492
Schistosoma mansoni protein phosphatase 2C 0.003 0.0171 0.0167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0012 0.0008
Echinococcus multilocularis lysine specific demethylase 5A 0.0112 0.1178 0.1174
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0073 0.0176
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0363 0.0536
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0139 0.1021
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0271 0.2023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0334 0.0383
Brugia malayi PHD-finger family protein 0.0033 0.0212 0.0362
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0033
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.01 0.0163
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0331 0.3882 0.8766
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0244 0.0358
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0014
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0222 0.0217
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0225 0.0329
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0139 0.0347
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0039 0.004
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0005 0.0008
Schistosoma mansoni jumonji domain containing protein 0.003 0.0171 0.0167
Echinococcus multilocularis dna polymerase kappa 0.0138 0.1506 0.1502
Schistosoma mansoni pyruvate kinase 0.0039 0.0282 0.0277
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0027 0.0134 0.0129
Schistosoma mansoni hypothetical protein 0.0041 0.0309 0.0304
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0199 0.0194
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0334 0.0329
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0527
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.1206 0.1201
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0282 0.0323
Mycobacterium ulcerans hypothetical protein 0.0033 0.0215 0.0476
Echinococcus granulosus pyruvate kinase 0.0039 0.0282 0.0277
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0052
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0801 0.1191
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0001 0.0001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0334 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0385 0.038
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0074 0.0103
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0171 0.0194
Echinococcus multilocularis geminin 0.0197 0.2226 0.2222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0052
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1358 0.2314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Echinococcus multilocularis histone acetyltransferase MYST2 0.0128 0.1383 0.1379
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0491 0.5853 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0918
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0485 0.0828
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1346 0.3033
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0673 0.151
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.122 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0244 0.0417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0055
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.1206 0.1201
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0078
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0244 0.024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0448 0.0663
Plasmodium falciparum thioredoxin reductase 0.0019 0.0039 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0244 0.024
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0244 0.0358
Schistosoma mansoni transcription factor LCR-F1 0.0085 0.0851 0.0846
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0481 0.0555
Schistosoma mansoni hypothetical protein 0.0018 0.0024 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0244 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0285 0.0634
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0282 0.0714
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0225 0.0454
Onchocerca volvulus 0.0096 0.0993 0.1479
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0107 0.1126 0.1122
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0215 0.0245
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.0993 0.0989
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0113 0.1191 0.1775
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0406 0.06
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0313 0.0697
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.1126 0.2535
Echinococcus granulosus zinc finger protein 0.0027 0.0136 0.0131
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0037 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0139 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0485 0.1166
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0244 0.0417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0244 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0244 0.0409
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0038 0.0065
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1358 0.2314
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0037 0.0032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1346 0.346
Giardia lamblia Pyruvate kinase 0.002 0.005 0.0026
Echinococcus multilocularis polycomb protein SCMH1 0.0113 0.1191 0.1187
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0096 0.0988 0.0984
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0012 0.0013
Schistosoma mansoni coup transcription factor 0.0036 0.0244 0.024
Onchocerca volvulus 0.0017 0.0012 0.0011
Schistosoma mansoni myelin transcription factor 1 myt1 0.0128 0.1383 0.1379
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0481 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0363 0.0536
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0244 0.0417
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.0215 0.0245
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Leishmania major DNA polymerase eta, putative 0.0197 0.2233 0.2598
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0282 0.0414
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1358 0.1354
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0049 0.0044
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Loa Loa (eye worm) MBCTL1 0.0128 0.1383 0.2357
Brugia malayi ImpB/MucB/SamB family protein 0.0197 0.2233 0.3815
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0459 0.0454
Brugia malayi jmjC domain containing protein 0.003 0.0171 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0244 0.0409
Plasmodium falciparum glutathione reductase 0.0019 0.0039 0.0089
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0012 0.0008
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0012 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0244 0.0417
Leishmania major mitochondrial DNA polymerase beta 0.0713 0.8582 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0074 0.0103
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0215 0.0245
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0673 0.0668
Schistosoma mansoni hypothetical protein 0.0024 0.01 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0916 0.0912
Echinococcus multilocularis SAM and MBT domain containing protein 0.0113 0.1191 0.1187
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0481 0.1076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0319 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0074 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0012 0.0008
Onchocerca volvulus 0.0019 0.0035 0.0046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0012 0.0013
Echinococcus multilocularis pyruvate kinase 0.0031 0.0181 0.0177
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0319 0.0314
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0039 0.0089
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0035
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0096 0.0988 0.0984
Echinococcus multilocularis GPCR, family 2 0.0019 0.0038 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.0673 0.5071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Trypanosoma brucei ISWI complex protein 0.0018 0.0024 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0215 0.0245
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0244 0.024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0363 0.0871
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0171 0.1265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0485 0.0821
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0916 0.0912
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0074 0.0178
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0085 0.0851 0.0846
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0138 0.0322
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0012 0.0021
Brugia malayi jmjC domain containing protein 0.003 0.0171 0.0293
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0107 0.1126 0.1122
Schistosoma mansoni hypothetical protein 0.0027 0.0134 0.0129
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0448 0.3365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0215 0.0245
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0027 0.0134 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0334 0.0492
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0244 0.024
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0244 0.024
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0244 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0459 0.0454
Brugia malayi jmjC domain containing protein 0.003 0.0171 0.0293
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0041 0.0309 0.2313
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1358 0.3491
Schistosoma mansoni ap endonuclease 0.0022 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0244 0.024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0334 0.0562
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0171 0.1265
Toxoplasma gondii thioredoxin reductase 0.0055 0.0481 0.3614
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0285 0.0634
Schistosoma mansoni phd/f-box containing protein 0.003 0.0171 0.0167
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0334 0.0383
Loa Loa (eye worm) DR-78 0.0017 0.0012 0.0013
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0139 0.0245
Loa Loa (eye worm) hypothetical protein 0.0064 0.0595 0.1009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0244 0.0417
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0244 0.024
Echinococcus multilocularis MAM 0.0019 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0527
Loa Loa (eye worm) hypothetical protein 0.0027 0.0138 0.0227
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0448 0.0663
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0139 0.0304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0407
Brugia malayi phosphofructokinase 0.0126 0.1358 0.232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0244 0.0409
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0244 0.024
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0363 0.0794
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0171 0.0194
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0171 0.191 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.0285
Plasmodium vivax JmjC domain containing protein 0.003 0.0171 0.043
Echinococcus granulosus chromobox protein 1 0.0081 0.0801 0.0796
Brugia malayi 6-phosphofructokinase 0.0126 0.1358 0.232
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0334 0.0329
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.005 0.0116
Brugia malayi hypothetical protein 0.0019 0.0035 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.01 0.1039 0.1206
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0171 0.0167
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0074 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0215 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Brugia malayi hypothetical protein 0.0017 0.0012 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0138 0.1506 0.175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0801 0.1361
Plasmodium vivax SET domain protein, putative 0.007 0.0673 0.1723
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0244 0.0417
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Brugia malayi Bromodomain containing protein 0.0091 0.0927 0.1584
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.1206 0.1201
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0033
Echinococcus multilocularis pyruvate kinase 0.002 0.005 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0459 0.0454
Brugia malayi Pre-SET motif family protein 0.0491 0.5853 1
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0215 0.0245
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.0215 0.0543
Echinococcus granulosus expressed protein 0.0039 0.0282 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0595 0.0688
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0171 0.0285
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0171 0.1914 0.4317
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0055 0.0485 0.1086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0459 0.0776
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.122 0.2748
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1358 0.1354
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0074 0.0081
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0225 0.0534
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0096 0.0988 0.0984
Entamoeba histolytica hypothetical protein 0.0027 0.0139 0.0327
Giardia lamblia PHD finger protein 15 0.0034 0.0222 0.0447
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.1818 0.1814
Onchocerca volvulus 0.0017 0.0019 0.0021
Brugia malayi mbt repeat family protein 0.0113 0.1191 0.2035
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0127 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0542 0.0918
Treponema pallidum fructose-bisphosphate aldolase 0.0351 0.4123 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0225 0.0567
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0673 0.0668
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0244 0.024
Brugia malayi Heterochromatin protein 1 0.0081 0.0801 0.1368
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1358 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Plasmodium vivax glutathione reductase, putative 0.0055 0.0481 0.1228
Schistosoma mansoni jumonji domain containing protein 0.0159 0.1758 0.1754
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0128 0.1383 0.1379
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0096 0.0988 0.0984
Brugia malayi steroid hormone receptor 0.0036 0.0244 0.0417
Echinococcus granulosus dna polymerase eta 0.0197 0.2233 0.2229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Onchocerca volvulus 0.0559 0.6689 1
Schistosoma mansoni hypothetical protein 0.0034 0.0222 0.0217
Schistosoma mansoni rotamase 0.0039 0.0282 0.0278
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0331 0.3882 1
Loa Loa (eye worm) glutathione reductase 0.0055 0.0481 0.0814
Schistosoma mansoni chromobox protein 0.0081 0.0801 0.0796
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0351 0.4123 1
Onchocerca volvulus Alhambra homolog 0.0034 0.0222 0.0325
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0282 0.0481
Trypanosoma cruzi DNA polymerase eta, putative 0.0123 0.1322 0.1536
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1518 0.3421
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0012 0.0008
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0222 0.0217
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0107 0.1126 0.1122
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.011 0.0158
Onchocerca volvulus 0.0017 0.0019 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0244 0.024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0039 0.004
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0282 0.0474
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Toxoplasma gondii hypothetical protein 0.0115 0.1221 0.9232
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0222 0.056
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0039 0.0052
Onchocerca volvulus 0.0017 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0485 0.0821
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0673 0.151
Onchocerca volvulus 0.0019 0.0035 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0665 0.1129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0074 0.0178
Loa Loa (eye worm) hypothetical protein 0.0045 0.0363 0.0613
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0801 0.1191
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0448 0.5322 0.532
Onchocerca volvulus 0.0021 0.006 0.0083
Echinococcus granulosus histone acetyltransferase MYST2 0.0128 0.1383 0.1379
Brugia malayi nuclear receptor NHR-67 0.0017 0.0012 0.0021
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0225 0.0454
Brugia malayi jmjC domain containing protein 0.0181 0.2038 0.3482
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0012 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.081 0.0939
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0448 0.1143
Giardia lamblia Pyruvate kinase 0.0039 0.0282 0.0594
Mycobacterium ulcerans DNA polymerase IV 0.0138 0.1506 0.3394
Loa Loa (eye worm) acetyltransferase 0.0171 0.191 0.3257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0244 0.0409
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.0215 0.021
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0215 0.0245
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0113 0.1191 0.2029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0085 0.0851 0.0846
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0271 0.0311
Brugia malayi ecdysteroid receptor 0.0036 0.0244 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0485 0.1086
Schistosoma mansoni zinc finger protein 0.0017 0.0012 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0244 0.024
Leishmania major pyruvate kinase 0.0039 0.0282 0.0323
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.01 0.1039 0.1206
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0122 0.1309 0.1521
Schistosoma mansoni zinc finger protein 0.0018 0.0024 0.0019
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0113 0.1191 0.1187
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0485 0.1086
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0171 0.0167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0271 0.0311
Brugia malayi nuclear hormone receptor 0.0017 0.0012 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0244 0.024
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0225 0.167
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0012 0.0008
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0074 0.346
Loa Loa (eye worm) RecQ helicase 0.0025 0.011 0.018
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0282 0.0626
Brugia malayi Muscle positioning protein 4 0.0017 0.0019 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0139 1
Mycobacterium ulcerans DNA polymerase IV 0.0138 0.1506 0.3394
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0139 0.0347
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0039 0.0262
Loa Loa (eye worm) apoptosis regulator protein 0.0096 0.0988 0.1682
Schistosoma mansoni hypothetical protein 0.0096 0.0988 0.0984
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0225 0.167
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0485 0.0828
Entamoeba histolytica hypothetical protein 0.0085 0.0851 0.2054
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0282 0.0414
Trypanosoma cruzi DNA polymerase eta, putative 0.0197 0.2233 0.2598
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1358 0.2025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0038 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0244 0.024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.1506 0.175
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0039 0.004
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0171 0.043
Brugia malayi acetyltransferase, GNAT family protein 0.0171 0.191 0.3263
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0334 0.0383
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0244 0.024
Schistosoma mansoni hypothetical protein 0.0096 0.0988 0.0984
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0038 0.0033
Echinococcus multilocularis peregrin 0.0041 0.0306 0.0302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0244 0.0417
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0139 0.0304
Entamoeba histolytica hypothetical protein 0.0085 0.0851 0.2054
Leishmania major hypothetical protein, conserved 0.0018 0.0024 0.0022
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0128 0.1383 0.2363
Leishmania major DNA damage repair protein, putative 0.0033 0.0215 0.0245
Trypanosoma brucei DNA polymerase eta, putative 0.0197 0.2233 0.2598
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0139 0.3652
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0171 0.191 0.1906
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0033
Echinococcus multilocularis chromobox protein 1 0.0081 0.0801 0.0796
Loa Loa (eye worm) hypothetical protein 0.0055 0.0485 0.0821
Trypanosoma brucei DNA polymerase IV, putative 0.0138 0.1506 0.175
Brugia malayi nuclear receptor RXR 0.0019 0.0037 0.0063
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0271 0.0311
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0005 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0171 0.0285
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1346 0.3033
Onchocerca volvulus 0.0055 0.0485 0.0718
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0077 0.0751 0.1276
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1358 0.306
Brugia malayi polk-prov protein 0.0064 0.0595 0.1017
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0313 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0673 0.0668
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0225 0.6773
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0039 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0542 0.0925
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0244 0.024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0337 0.3959 0.461
Schistosoma mansoni hypothetical protein 0.0096 0.0988 0.0984
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0459 0.0784
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0222 0.0217
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0074 0.0069
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0225 0.0567
Entamoeba histolytica hypothetical protein 0.0085 0.0851 0.2054
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0485 0.1086
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0244 0.024
Schistosoma mansoni hypothetical protein 0.0085 0.0851 0.0846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0459 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.02 0.0292
Brugia malayi chromobox protein homolog 3 0.0045 0.0363 0.062
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0049 0.0044
Brugia malayi jmjC domain containing protein 0.0114 0.1206 0.206
Loa Loa (eye worm) hypothetical protein 0.0197 0.2233 0.381
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0039 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.1506 0.175
Brugia malayi hypothetical protein 0.0038 0.0278 0.0475
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0271 0.0311
Brugia malayi hypothetical protein 0.0085 0.0851 0.1453
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0282 0.0475
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0459 0.0454
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0012 0.0008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1358 0.1578
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1358 0.2025
Chlamydia trachomatis pyruvate kinase 0.0039 0.0282 0.8856
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0024
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0225 0.6773
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0334 0.057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0074 0.0085
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0049 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0713 0.8582 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0527
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0282 0.0714
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.0538 0.0621
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0225 0.0329
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0012 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0406 0.06
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0222 0.1647
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.02 0.0292
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0282 0.0414
Loa Loa (eye worm) hypothetical protein 0.0082 0.0816 0.1386
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0138 0.1506 0.2246
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0138 0.0227
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0282 0.0323
Echinococcus granulosus MAM 0.0019 0.0035 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0039 0.0262
Brugia malayi mbt repeat family protein 0.0113 0.1191 0.2035
Schistosoma mansoni nuclear receptor 0.0017 0.0012 0.0008
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0039 0.0089
Echinococcus granulosus polycomb protein SCMH1 0.0113 0.1191 0.1187
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0481 0.1228
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0309 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0244 0.0417
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0313 0.0795
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0282 0.0323
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0282 0.0474
Loa Loa (eye worm) hypothetical protein 0.0054 0.0465 0.0787
Leishmania major hypothetical protein, conserved 0.003 0.0171 0.0194
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0181 0.2038 0.2034
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0282 0.0482
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0282 0.0474
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0038 0.0057
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0012 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1506 0.175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0013
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1358 0.1578
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0448 0.5322 0.532
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0334 0.0329
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.0993 0.0989
Trypanosoma cruzi ISWI complex protein 0.0018 0.0024 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0244 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0244 0.024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0244 0.024
Leishmania major pyruvate kinase 0.0039 0.0282 0.0323
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0916 0.0912
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0244 0.0417
Onchocerca volvulus 0.0017 0.0019 0.0021
Echinococcus granulosus pyruvate kinase 0.002 0.005 0.0045
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1358 0.2314
Schistosoma mansoni nuclear receptor 0.0017 0.0012 0.0008
Plasmodium falciparum thioredoxin reductase 0.0055 0.0481 0.1228
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0012 0.0008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0055 0.0485 0.1086
Echinococcus multilocularis dna polymerase eta 0.0197 0.2233 0.2229
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0171 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0448 0.3365
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0012 0.0013
Schistosoma mansoni terminal deoxycytidyl transferase 0.0107 0.1126 0.1122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0244 0.0417
Brugia malayi hypothetical protein 0.0017 0.0012 0.0021
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.0215 0.0543
Trypanosoma brucei DNA polymerase beta thumb, putative 0.01 0.1039 0.1206
Onchocerca volvulus 0.0036 0.0243 0.0356
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0012 0.0021
Trypanosoma brucei unspecified product 0.013 0.1412 0.164
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0059 0.0538 0.0911
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0074 0.0069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0406 0.06
Schistosoma mansoni pyruvate kinase 0.002 0.005 0.0045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0448 0.0443
Plasmodium falciparum phd finger protein, putative 0.0034 0.0222 0.056
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.013 0.1412 0.164
Loa Loa (eye worm) hypothetical protein 0.0096 0.0988 0.1682
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0244 0.024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1518 0.3421
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0351 0.4123 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0244 0.0409
Brugia malayi Bromodomain containing protein 0.0049 0.0403 0.0689
Schistosoma mansoni DNA polymerase eta 0.0197 0.2233 0.2229
Echinococcus multilocularis pyruvate kinase 0.002 0.005 0.0045
Brugia malayi glutathione reductase 0.0055 0.0481 0.0821
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0096 0.0988 0.1688
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1358 0.2025
Loa Loa (eye worm) hypothetical protein 0.0051 0.0438 0.0741
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0039 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.004
Giardia lamblia DNA damage repair protein 0.0033 0.0215 0.0431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0713 0.8582 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0171 0.0167
Trichomonas vaginalis rotamase, putative 0.0038 0.0271 0.0399
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.0538 0.1374
Leishmania major DNA polymerase kappa, putative 0.0115 0.122 0.1417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.081 0.0939
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0039 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0244 0.0409
Echinococcus multilocularis chromobox protein 1 0.0081 0.0801 0.0796
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1346 0.3033
Brugia malayi tailless protein 0.0017 0.0012 0.0021
Mycobacterium ulcerans hypothetical protein 0.0375 0.4428 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0244 0.0358
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0074 0.0168
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0282 0.0323
Leishmania major trypanothione reductase 0.0055 0.0481 0.0555
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0012 0.0008
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0171 0.1914 0.4925
Brugia malayi hypothetical protein 0.0019 0.0037 0.0063
Treponema pallidum hypothetical protein 0.0331 0.3882 0.941
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0009 0.0031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0039 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.1506 0.175
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0128 0.1383 0.1379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0244 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0527
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0074 0.0085
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0244 0.024
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0244 0.024
Toxoplasma gondii LsmAD domain-containing protein 0.0059 0.0538 0.4046
Echinococcus multilocularis pyruvate kinase 0.0039 0.0282 0.0277
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0334 0.0383
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0225 0.167
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0074 0.0126
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1358 0.3286
Trypanosoma brucei unspecified product 0.0074 0.0716 0.0829
Entamoeba histolytica hypothetical protein 0.0085 0.0851 0.2054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0171 0.1914 0.4317
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0038 0.0065
Echinococcus multilocularis bloom syndrome protein 0.0025 0.011 0.0105
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0037 0.0055
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0282 0.2103
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0039 0.004
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0005 0.0008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0107 0.1126 0.1917
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0084 0.0836 0.0831
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0012 0.0008
Leishmania major DNA polymerase eta, putative 0.0123 0.1322 0.1536
Echinococcus multilocularis expressed protein 0.0039 0.0282 0.0278
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.005 0.0342
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0673 0.0668
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0331 0.3882 0.8766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0285 0.0634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0351 0.4123 0.6161
Mycobacterium tuberculosis Probable reductase 0.0125 0.1346 0.3033
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0244 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.081 0.0939

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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