Detailed information for compound 1562382

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.111 | Formula: C27H44ClN3O
  • H donors: 1 H acceptors: 1 LogP: 9.07 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@H]1C(=N)N)c1ccc(cc1)CCCCCCCCCC1CCCCC1.Cl
  • InChi: 1S/C27H43N3O.ClH/c28-26(29)25-16-11-21-30(25)27(31)24-19-17-23(18-20-24)15-8-5-3-1-2-4-7-12-22-13-9-6-10-14-22;/h17-20,22,25H,1-16,21H2,(H3,28,29);1H/t25-;/m0./s1
  • InChiKey: FOMDCYKVSBQNKN-UQIIZPHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus sphingosine kinase 2 Starlite/ChEMBL References
Homo sapiens sphingosine kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sphingosine kinase A B Get druggable targets OG5_128162 All targets in OG5_128162
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma mansoni sphingoid long chain base kinase Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
Echinococcus granulosus sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium tuberculosis Conserved protein Get druggable targets OG5_128162 All targets in OG5_128162
Echinococcus multilocularis sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma japonicum ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative Get druggable targets OG5_128162 All targets in OG5_128162
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Loa Loa (eye worm) hypothetical protein 0.0061 0.0374 0.1433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0016 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0088 0.0076
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0191 0.1058
Brugia malayi GnHR receptor homolog 0.0034 0.0191 0.0914
Brugia malayi Serotonin receptor 0.0034 0.0191 0.0914
Brugia malayi Dopamine receptor protein 2 0.0034 0.0191 0.0914
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0191 0.0183
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0026 0.0129 0.059
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0014 0.0051 0.0142
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.029 0.0277
Brugia malayi mbt repeat family protein 0.005 0.0296 0.1466
Schistosoma mansoni sodium/chloride dependent transporter 0.0061 0.0374 0.1444
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Echinococcus multilocularis nAChR subunit 0.0026 0.0129 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0088 0.0378
Loa Loa (eye worm) hypothetical protein 0.0165 0.1099 0.4331
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.1309 0.1298
Brugia malayi mbt repeat family protein 0.005 0.0296 0.1466
Schistosoma mansoni DNA helicase recq5 0.0009 0.0017 0.0018
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0016 0.0003
Toxoplasma gondii hypothetical protein 0.001 0.0023 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0061 0.0374 0.1444
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.009 0.0077
Echinococcus granulosus sodium and chloride dependent glycine 0.001 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.0191 0.0178
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0278 0.1881 0.7425
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.0191 0.0699
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0191 0.0699
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0016 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Schistosoma mansoni glutaminase 0.0284 0.1926 0.7645
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0088 0.0378
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0191 0.0699
Schistosoma mansoni cpg binding protein 0.0031 0.0166 0.0611
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0198 0.0595
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Mycobacterium ulcerans oxidoreductase 0.0021 0.0098 0.0188
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0074 0.1796
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.029 0.7246
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0191 0.0711
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0088 0.0289
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0111 0.0574
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0191 0.0711
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0051 0.0556
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0033 0.0021
Schistosoma mansoni histamine h1 receptor 0.0034 0.0191 0.0711
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.029 0.1504
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0098 0.2651
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0017 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0227 0.0712
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0014 0.0051 0.004
Schistosoma mansoni amine GPCR 0.0034 0.0191 0.0711
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0191 0.0711
Echinococcus multilocularis serotonin receptor 0.0165 0.1099 0.1114
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0098 0.034
Brugia malayi SWIRM domain containing protein 0.0021 0.0098 0.0428
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0191 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Echinococcus multilocularis serotonin receptor 0.0165 0.1099 0.1114
Loa Loa (eye worm) GABA receptor subunit 0.0014 0.0047 0.0124
Brugia malayi G protein-coupled receptor 0.0034 0.0191 0.0914
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0051 0.0556
Toxoplasma gondii thioredoxin reductase 0.0051 0.0304 0.7627
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0191 0.0178
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0074 0.1969
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0026 0.0129 0.059
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0191 0.0178
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.001 0.0023 0.0011
Echinococcus multilocularis sex peptide receptor 0.0034 0.0191 0.0183
Plasmodium vivax diacylglycerol kinase, putative 0.0014 0.0051 0.1002
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0016 0.0013
Loa Loa (eye worm) glutaminase 0.0284 0.1926 0.7642
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0191 0.0699
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0191 0.0178
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0304 0.0292
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Echinococcus granulosus sodium and chloride dependent glycine 0.001 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0296 0.1132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0756 0.2858
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0033 0.0082
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0344 0.034
Echinococcus granulosus Diacylglycerol kinase theta 0.0014 0.0051 0.0039
Loa Loa (eye worm) ceramide kinase 0.0014 0.0051 0.0142
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0017 0.0007
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Schistosoma mansoni regulator of G protein signaling 0.002 0.009 0.0309
Echinococcus granulosus sphingosine kinase 1 0.0369 0.2516 0.2506
Schistosoma mansoni coup transcription factor 0.002 0.0088 0.0301
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0344 0.034
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0051 0.0267
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0191 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0191 0.0914
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0012 0.0033 0.0069
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.001 0.0023 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0191 0.0711
Onchocerca volvulus 0.0034 0.0191 0.1058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0098 0.0188
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Onchocerca volvulus 0.0061 0.0374 0.2169
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0088 0.0437
Brugia malayi sulfakinin receptor protein 0.0034 0.0191 0.0914
Echinococcus granulosus neuropeptide receptor 0.0034 0.0191 0.0178
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0129 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0191 0.0178
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0088 0.0077
Schistosoma mansoni biogenic amine receptor 0.0034 0.0191 0.0711
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.001 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0227 0.0768
Brugia malayi hypothetical protein 0.001 0.0024 0.004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0191 0.0699
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.001 0.0023 0.0042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0166 0.0599
Schistosoma mansoni adenoreceptor 0.0034 0.0191 0.0711
Onchocerca volvulus Ceramide kinase 1 homolog 0.0014 0.0051 0.0215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0393 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0098 0.0085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0016 0.0013
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0047 0.0162
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0026 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.009 0.0388
Schistosoma mansoni hypothetical protein 0.0059 0.0362 0.1395
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Trypanosoma brucei trypanothione reductase 0.0051 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0172 0.0159
Schistosoma mansoni nuclear receptor 0.0009 0.0016 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Echinococcus granulosus uncharacterized sodium dependent transporter 0.001 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0016 0.0003
Onchocerca volvulus 0.0034 0.0191 0.1058
Onchocerca volvulus 0.0034 0.0191 0.1058
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0051 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0088 0.0289
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0098 0.2286
Loa Loa (eye worm) hypothetical protein 0.0165 0.1099 0.4331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0088 0.0289
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0016 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0846 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0129 0.0119
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0155
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0227 0.5576
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0802 0.0791
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0012 0.0033 0.0091
Plasmodium falciparum glutathione reductase 0.0018 0.0074 0.1969
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.009 0.0388
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0161
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0033 0.0069
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0017 0.0005
Entamoeba histolytica hypothetical protein 0.002 0.009 0.0216
Brugia malayi Cation transporter family protein 0.0026 0.0129 0.059
Schistosoma mansoni hypothetical protein 0.0176 0.1176 0.4646
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0111 0.2487
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0088 0.0378
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0191 0.0178
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0191 0.0178
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.009 0.0077
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni neuropeptide receptor 0.0034 0.0191 0.0711
Echinococcus granulosus bloom syndrome protein 0.0023 0.0111 0.0098
Onchocerca volvulus 0.0026 0.0129 0.0683
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.0191 0.0914
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0191 0.0178
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0191 0.0183
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0074 0.1969
Echinococcus multilocularis nAChR subunit 0.0014 0.0047 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0051 0.0267
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0299 0.2027 0.8018
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0026 0.0129 0.0119
Loa Loa (eye worm) acetylcholine receptor protein 0.0012 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0026 0.0129 0.0451
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0129 0.0119
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.009 0.0467
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0172 0.4111
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0026 0.0129 0.0119
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Brugia malayi Ceramide kinase 0.0014 0.0051 0.0186
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0624
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0098 0.2806
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0191 0.0914
Brugia malayi ORL1-like opioid receptor 0.0034 0.0191 0.0914
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0047 0.0137
Loa Loa (eye worm) hypothetical protein 0.0369 0.2516 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0026 0.0129 0.0451
Schistosoma mansoni myosin xvIII 0.0034 0.0191 0.0711
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0088 0.0378
Trypanosoma brucei diacylglycerol kinase, putative 0.0014 0.0051 0.0556
Brugia malayi AKH receptor 0.0034 0.0191 0.0914
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0088 0.0077
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0191 0.0699
Plasmodium vivax SET domain protein, putative 0.0032 0.0172 0.529
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0074 0.0063
Onchocerca volvulus 0.0014 0.0047 0.0188
Loa Loa (eye worm) RGS-3 protein 0.002 0.009 0.0296
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.001 0.0023 0.0042
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0129 0.0116
Onchocerca volvulus 0.0034 0.0191 0.1058
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0191 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0088 0.0077
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0129 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0302 0.2046 0.8124
Loa Loa (eye worm) hypothetical protein 0.0061 0.0374 0.1433
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.009 0.0079
Schistosoma mansoni inositol monophosphatase 0.004 0.0227 0.0856
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0013
Schistosoma mansoni sodium/chloride dependent transporter 0.001 0.0023 0.0042
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0296 0.1132
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0088 0.0301
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0074 0.2312
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0129 0.0116
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0026 0.0129 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0017 0.0005
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0014 0.0051 0.0155
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0846 0.3223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0129 0.059
Entamoeba histolytica hypothetical protein 0.002 0.009 0.0216
Leishmania major diacylglycerol kinase, putative 0.0014 0.0051 0.0556
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0227 0.1178
Onchocerca volvulus 0.0026 0.0129 0.0683
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0074 0.0061
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.001 0.0023 0.0042
Mycobacterium tuberculosis Conserved protein 0.0369 0.2516 1
Onchocerca volvulus 0.001 0.0023 0.0044
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0074 0.1502
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0227 0.7116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Schistosoma mansoni acetylcholine receptor subunit beta 0.0012 0.0033 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0172 0.0636
Schistosoma mansoni axis inhibition protein axin 0.002 0.009 0.0309
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Echinococcus granulosus g protein coupled receptor 0.0034 0.0191 0.0178
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.0191 0.0711
Echinococcus granulosus cpg binding protein 0.0033 0.0178 0.0165
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0029
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0191 0.0178
Onchocerca volvulus 0.002 0.0088 0.0437
Onchocerca volvulus 0.0014 0.0051 0.0215
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0191 0.0183
Brugia malayi neuropeptide F receptor 0.0034 0.0191 0.0914
Schistosoma mansoni regulator of G protein signaling 0.002 0.009 0.0309
Echinococcus granulosus g protein coupled receptor 0.0034 0.0191 0.0178
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0098 0.214
Schistosoma mansoni amine GPCR 0.0034 0.0191 0.0711
Schistosoma mansoni amine GPCR 0.0034 0.0191 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0088 0.0289
Brugia malayi excitatory GABA receptor EXP-1A 0.0026 0.0129 0.059
Onchocerca volvulus 0.0026 0.0129 0.0683
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Schistosoma mansoni sphingoid long chain base kinase 0.0369 0.2516 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.001 0.0023 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0191 0.0711
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0098 0.2286
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0016 0.0003
Entamoeba histolytica hypothetical protein 0.0014 0.0047 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0227 0.0215
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0756 0.2858
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0031
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0088 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Echinococcus multilocularis sodium and chloride dependent glycine 0.001 0.0023 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0088 0.0301
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0026 0.0129 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.001 0.0023 0.0042
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0014 0.0051 0.004
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0129 0.0451
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0262 0.0908
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0014 0.0051 0.0155
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0159 0.0147
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0111 0.0101
Onchocerca volvulus 0.0247 0.1667 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Onchocerca volvulus Putative nachr subunit 0.0026 0.0129 0.0683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0036 0.0189
Echinococcus granulosus neuropeptide receptor 0.0034 0.0191 0.0178
Brugia malayi G-protein coupled receptor 0.0034 0.0191 0.0914
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0191 0.0178
Brugia malayi Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0038
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0191 0.0178
Trichomonas vaginalis set domain proteins, putative 0.0247 0.1667 0.8656
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Echinococcus granulosus g protein coupled receptor 0.0034 0.0191 0.0178
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0098 0.034
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0017 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.029 0.9489
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.009 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0088 0.0378
Trypanosoma brucei Sphingosine kinase 0.0014 0.0051 0.0556
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.009 0.0077
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.004
Brugia malayi CXXC zinc finger family protein 0.0031 0.0166 0.0784
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0098 0.0428
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0191 0.0183
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0025 0.0047
Brugia malayi ecdysteroid receptor 0.002 0.0088 0.0378
Onchocerca volvulus 0.0012 0.0033 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni zinc finger protein 0.0009 0.0016 0.0013
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0129 0.0116
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Echinococcus multilocularis conserved hypothetical protein 0.1412 0.9761 1
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0191 0.0178
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.009 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0191 0.0711
Mycobacterium ulcerans dehydrogenase 0.0021 0.0098 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.029 0.1504
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0088 0.0378
Brugia malayi nuclear receptor RXR 0.001 0.0024 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0088 0.0077
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0191 0.0183
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0051 0.0556
Brugia malayi larval opioid receptor 0.0034 0.0191 0.0914
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0026 0.0129 0.0451
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.0033 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0088 0.0301
Trichomonas vaginalis glutaminase, putative 0.0284 0.1926 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0098 0.2806
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0026 0.0129 0.0451
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0088 0.0076
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0165 0.1099 0.4339
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0296 0.1121
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0091 0.2583
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0074 0.0091
Schistosoma mansoni opsin-like receptor 0.0034 0.0191 0.0711
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0047 0.0137
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0296 0.0284
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Schistosoma mansoni amine GPCR 0.0034 0.0191 0.0711
Echinococcus granulosus FTZ F1 alpha 0.002 0.0088 0.0076
Echinococcus multilocularis sphingosine kinase 1 0.0369 0.2516 0.2568
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0098 0.0087
Brugia malayi Eye-specific diacylglycerol kinase 0.0014 0.0051 0.0186
Echinococcus granulosus geminin 0.0176 0.1176 0.1164
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus multilocularis 0.0021 0.0098 0.0087
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0191 0.0183
Brugia malayi G-protein coupled receptor 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0191 0.0178
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0026 0.0129 0.059
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0129 0.0119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0191 0.0183
Onchocerca volvulus 0.001 0.0023 0.0044
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0098 0.2651
Plasmodium vivax diacylglycerol kinase, putative 0.0014 0.0051 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0304 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.009 0.0079
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0191 0.0914
Echinococcus multilocularis Diacylglycerol kinase theta 0.0014 0.0051 0.004
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.009 0.0077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0088 0.0076
Echinococcus granulosus fmrfamide receptor 0.0034 0.0191 0.0178
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0088 0.0301
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0098 0.0188
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni opsin-like receptor 0.0034 0.0191 0.0711
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0756 0.2858
Plasmodium falciparum thioredoxin reductase 0.0051 0.0304 1
Onchocerca volvulus 0.0034 0.0191 0.1058
Echinococcus multilocularis axis inhibition protein axin 0.002 0.009 0.0079
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.0939 0.095
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0191 0.0178
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0074 0.0091
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0846 0.3223
Echinococcus granulosus nAChR subunit 0.0014 0.0047 0.0034
Brugia malayi Dopamine receptor protein 1 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Brugia malayi hypothetical protein 0.0012 0.0033 0.0091
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0088 0.0378
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0296 0.0291
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0051 0.0556
Schistosoma mansoni hypothetical protein 0.0176 0.1176 0.4646
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0047 0.0162
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0191 0.0178
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0088 0.0301
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0033 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0088 0.0378
Brugia malayi RE15519p 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0129 0.059
Trichomonas vaginalis bmru protein, putative 0.0014 0.0051 0.0267
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.009 0.0388
Echinococcus multilocularis serotonin transporter 0.0061 0.0374 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Onchocerca volvulus 0.0012 0.0033 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0191 0.0183
Brugia malayi hypothetical protein 0.001 0.0024 0.004
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0041 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0088 0.0378
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0074 0.1389
Leishmania major hypothetical protein, conserved 0.0014 0.0051 0.0556
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.001 0.0023 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0077 0.0258
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0026 0.0129 0.059
Schistosoma mansoni diacylglycerol kinase theta 0.0014 0.0051 0.0155
Schistosoma mansoni regulator of G protein signaling 0.002 0.009 0.0309
Schistosoma mansoni nAChR subunit 0.0012 0.0033 0.0082
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0026 0.0129 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0026 0.0129 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0088 0.0076
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0172 0.0163
Schistosoma mansoni acetylcholine receptor-related 0.0012 0.0033 0.0082
Plasmodium falciparum diacylglycerol kinase, putative 0.0014 0.0051 0.1192
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.009 0.0079
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0227 0.1178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.0191 0.0183
Schistosoma mansoni nuclear receptor 0.0009 0.0016 0.0013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0041 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0033 0.0091
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0098 0.0188
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0191 0.0183
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0191 0.0183
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0061 0.0374 0.1875
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.0129 0.059
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0088 0.0289
Echinococcus granulosus biogenic amine 5HT receptor 0.0165 0.1099 0.1087
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0088 0.0077
Echinococcus multilocularis somatostatin receptor 0.0034 0.0191 0.0183
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0191 0.0178
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Loa Loa (eye worm) glutathione reductase 0.0051 0.0304 0.1153
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Onchocerca volvulus 0.0026 0.0129 0.0683
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Brugia malayi hypothetical protein 0.0012 0.0033 0.0091
Schistosoma mansoni regulator of G protein signaling 0.002 0.009 0.0309
Onchocerca volvulus 0.0032 0.0172 0.0944
Toxoplasma gondii diacylglycerol kinase, putative 0.0014 0.0051 0.0909
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0051 0.006
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0191 0.0914
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0012 0.0033 0.0021
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0024 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0191 0.0699
Brugia malayi Thioredoxin reductase 0.0051 0.0304 0.1508
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Plasmodium falciparum thioredoxin reductase 0.0018 0.0074 0.1969
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0191 0.0183
Leishmania major UDP-galactopyranose mutase 0.0021 0.0098 0.2286
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Onchocerca volvulus 0.0031 0.0166 0.0907
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.009 0.0079
Brugia malayi steroid hormone receptor 0.002 0.0088 0.0378
Schistosoma mansoni biogenic amine receptor 0.0034 0.0191 0.0711
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0058 0.108
Echinococcus granulosus somatostatin receptor 0.0034 0.0191 0.0178
Schistosoma mansoni sphingosine kinase A B 0.0369 0.2516 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.009 0.0077
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0227 1
Mycobacterium tuberculosis Probable reductase 0.0116 0.0756 0.2858
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0074 0.0091
Echinococcus granulosus nAChR subunit 0.0026 0.0129 0.0116
Brugia malayi Diacylglycerol kinase protein 2 0.0014 0.0051 0.0186
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0098 0.2651
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0191 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0142 0.0939 0.37
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0016 0.0013
Brugia malayi hypothetical protein 0.0012 0.0033 0.0091
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0296 0.0284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0031
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0051 0.0556
Echinococcus granulosus axis inhibition protein axin 0.002 0.009 0.0077
Onchocerca volvulus 0.005 0.0296 0.1696
Brugia malayi glutathione reductase 0.0051 0.0304 0.1508
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Schistosoma mansoni biogenic amine receptor 0.0034 0.0191 0.0711
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.0033 0.0091
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0296 0.0291
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0227 0.022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0017 0.00000000079525
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni neuropeptide receptor 0.0034 0.0191 0.0711
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0191 0.0178
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0129 0.0116
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0016 0.0003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.009 0.0309
Brugia malayi Cation transporter family protein 0.0026 0.0129 0.059
Echinococcus multilocularis geminin 0.0176 0.1176 0.1193
Loa Loa (eye worm) diacylglycerol kinase 2 0.0014 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0016 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1069 0.1058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0088 0.0289
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0026 0.0129 0.059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0088 0.0289
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0074 0.1389
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.001 0.0023 0.0042
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0026 0.0129 0.0464
Schistosoma mansoni diacylglycerol kinase theta 0.0014 0.0051 0.0155
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0088 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0051 0.0267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0304 0.1025
Schistosoma mansoni axis inhibition protein axin 0.002 0.009 0.0309
Echinococcus multilocularis cpg binding protein 0.0033 0.0178 0.017
Brugia malayi PXA domain containing protein 0.002 0.009 0.0388
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0088 0.0076
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0098 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0024 0.0044
Schistosoma mansoni nuclear hormone receptor 0.002 0.0088 0.0301
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0191 0.0711
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Leishmania major diacylglycerol kinase-like protein 0.0014 0.0051 0.0556
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0088 0.0301
Loa Loa (eye worm) MBCTL1 0.0056 0.0344 0.1311
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0016 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Onchocerca volvulus 0.001 0.0023 0.0044
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0802 0.081
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0074 0.0382
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0051 0.0556
Brugia malayi hypothetical protein 0.002 0.009 0.0388
Onchocerca volvulus 0.0026 0.0129 0.0683
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0088 0.0437
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0191 0.0699
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Schistosoma mansoni sodium-dependent amino acid transporter 0.001 0.0023 0.0042
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.001 0.0023 0.0042
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0191 0.0699
Mycobacterium ulcerans glutaminase 0.0284 0.1926 0.7608
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.009 0.0079
Brugia malayi nuclear hormone receptor 0.002 0.0088 0.0378
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0033 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Onchocerca volvulus 0.0014 0.0047 0.0188
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Onchocerca volvulus 0.0034 0.0191 0.1058
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0299 0.2027 0.8018
Schistosoma mansoni inositol monophosphatase 0.004 0.0227 0.0856
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0111 0.0496
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0088 0.0378
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0304 0.1153
Schistosoma mansoni DNA helicase recq1 0.0009 0.0017 0.0018
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0074 0.1796
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0191 0.0711
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0191 0.0178
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0051 0.0556
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0024 0.0044
Brugia malayi Pre-SET motif family protein 0.0032 0.0172 0.0816
Echinococcus granulosus uncharacterized sodium dependent transporter 0.001 0.0023 0.0011
Leishmania major trypanothione reductase 0.0051 0.0304 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0129 0.0116
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0191 0.0183
Schistosoma mansoni regulator of G protein signaling 0.002 0.009 0.0309
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0026 0.0129 0.0464
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0012 0.0033 0.0021
Brugia malayi glutaminase DH11.1 0.0284 0.1926 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0191 0.0711
Echinococcus multilocularis axis inhibition protein axin 0.002 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0129 0.0116
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0074 0.1389
Mycobacterium ulcerans hypothetical protein 0.0369 0.2516 1
Echinococcus granulosus ceramide kinase 0.0014 0.0051 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.002 0.009 0.0309
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.009 0.0388
Onchocerca volvulus 0.0034 0.0191 0.1058
Brugia malayi Sodium:neurotransmitter symporter family protein 0.001 0.0023 0.0038
Onchocerca volvulus 0.0034 0.0191 0.1058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0262 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0191 0.0183
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0074 0.0244
Loa Loa (eye worm) inositol-1 0.004 0.0227 0.0844
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0056 0.0344 0.1311
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0088 0.0378
Schistosoma mansoni sodium/chloride dependent transporter 0.001 0.0023 0.0042
Echinococcus granulosus serotonin transporter 0.0061 0.0374 0.0362
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0191 0.0178
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0129 0.0119
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.005 0.0296 0.1121
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0013
Plasmodium falciparum diacylglycerol kinase, putative 0.0014 0.0051 0.1192
Brugia malayi hypothetical protein 0.0012 0.0033 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.002 0.009 0.0309
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0088 0.0076
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0129 0.0464
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0296 0.1132
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Schistosoma mansoni cpg binding protein 0.0033 0.0178 0.066
Brugia malayi hypothetical protein 0.0014 0.0051 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0051 0.0556
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0191 0.0183
Onchocerca volvulus 0.0012 0.0033 0.0105
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0098 0.2806
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0088 0.0301
Entamoeba histolytica hypothetical protein 0.002 0.009 0.0216
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi putative neuropeptide receptor 0.0034 0.0191 0.0914
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0012 0.0033 0.0021
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0129 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0016 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0191 0.0183
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0191 0.0711
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0074 0.1389
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0129 0.0464
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0191 0.0711
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0129 0.0119
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0191 0.0711
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0014 0.0047 0.0137
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0191 0.0183
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0191 0.0183
Schistosoma mansoni neuropeptide receptor 0.0034 0.0191 0.0711
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0142
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0026 0.0129 0.0116
Treponema pallidum sodium- and chloride- dependent transporter 0.0061 0.0374 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0088 0.0378
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0711
Brugia malayi neuropeptide F receptor 0.0034 0.0191 0.0914
Echinococcus multilocularis expressed protein 0.0388 0.2648 0.2703
Schistosoma mansoni serine/threonine protein kinase 0.002 0.009 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni cpg binding protein 0.0033 0.0178 0.066
Echinococcus multilocularis regulator of G protein signaling 0.002 0.009 0.0079
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.0191 0.0183
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.001 0.0023 0.0011
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0014 0.0051 0.0039
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.009 0.0296
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0756 0.2858
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.009 0.0077
Brugia malayi diacylglycerol kinase 0.0014 0.0051 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.001 0.0023 0.0011
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0129 0.0116
Trichomonas vaginalis bmru protein, putative 0.0014 0.0051 0.0267
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0191 0.0183
Brugia malayi Melatonin receptor type 1A 0.0034 0.0191 0.0914
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0014 0.0051 0.0909
Echinococcus granulosus expressed protein 0.0388 0.2648 0.2639
Echinococcus granulosus Diacylglycerol kinase zeta 0.0014 0.0051 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Leishmania major sphingosine kinase A, B, putative 0.0014 0.0051 0.0556
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0111 0.0574
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0051 0.0556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0051 0.006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0414 0.1602
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0191 0.0914
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.1102 0.5684
Schistosoma mansoni amine GPCR 0.0034 0.0191 0.0711
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0191 0.0711
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0227 0.7116
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0711
Brugia malayi diacylglycerol kinase 0.0014 0.0051 0.0186
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0344 0.0332
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.009 0.0296
Schistosoma mansoni neuropeptide receptor 0.0034 0.0191 0.0711
Plasmodium falciparum amino acid transporter, putative 0.001 0.0023 0.0211
Schistosoma mansoni thyroid hormone receptor 0.0142 0.0939 0.37
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0344 0.1323
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0024 0.0031
Echinococcus multilocularis ceramide kinase 0.0014 0.0051 0.004
Schistosoma mansoni nAChR subunit 0.0026 0.0129 0.0464
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.009 0.0388
Brugia malayi follicle stimulating hormone receptor 0.0034 0.0191 0.0914
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0024 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Echinococcus granulosus neuropeptide s receptor 0.0034 0.0191 0.0178
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0846 0.3223
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0029
Brugia malayi nuclear receptor NHR-88 0.002 0.0088 0.0378
Brugia malayi hypothetical protein 0.0034 0.0191 0.0914
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0191 0.0178
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0191 0.0711
Brugia malayi hypothetical protein 0.0012 0.0033 0.0091
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0098 0.0087
Loa Loa (eye worm) glutaminase 2 0.0284 0.1926 0.7642
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0304 0.0299
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0344 0.1716
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0191 0.0711
Schistosoma mansoni nAChR subunit 0.0012 0.0033 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0088 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Echinococcus multilocularis sodium and chloride dependent glycine 0.001 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0088 0.0289
Brugia malayi hypothetical protein 0.001 0.0023 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0098 0.2651
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0026 0.0129 0.059
Loa Loa (eye worm) hypothetical protein 0.0061 0.0374 0.1433
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0059 0.1277
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0088 0.0301
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.146 0.5775
Echinococcus granulosus axis inhibition protein axin 0.002 0.009 0.0077
Brugia malayi Cation transporter family protein 0.0026 0.0129 0.059
Schistosoma mansoni hypothetical protein 0.0122 0.0802 0.3155
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.009 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0756 0.2858
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0227 0.1178
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0129 0.059
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0191 0.0183
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0074 0.0302
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0074 0.0382
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0051 0.006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0227 0.7116
Brugia malayi Inositol-1 0.004 0.0227 0.1104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0172 0.0636
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0296
Brugia malayi hypothetical protein 0.002 0.009 0.0388
Loa Loa (eye worm) LGC-31 protein 0.0026 0.0129 0.0451
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni opsin-like receptor 0.0034 0.0191 0.0711
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0756 0.88
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.009 0.0388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0327
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0191 0.0178
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0016 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0129 0.059
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0191 0.0178
Echinococcus granulosus serotonin receptor 0.0034 0.0191 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0191 0.1058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0088 0.0378
Loa Loa (eye worm) norepinephrine transporter 0.0061 0.0374 0.1433
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0047 0.0162
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0129 0.0119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0172 0.0163
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0051 0.0556
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.009 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0074 0.1389
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0074 0.1389
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0711
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0051 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0172 0.0636
Echinococcus granulosus orexin receptor type 2 0.0034 0.0191 0.0178
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0098 0.0188
Toxoplasma gondii hypothetical protein 0.001 0.0023 0.0161
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.1102 0.4351
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0074 0.1389
Echinococcus granulosus sex peptide receptor 0.0034 0.0191 0.0178
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0191 0.0699
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0129 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0088 0.0378
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0191 0.0711
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.1309 0.133
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0026 0.0129 0.0464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0129 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0191 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0017 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.1102 0.1117
Loa Loa (eye worm) acetyltransferase 0.0166 0.1102 0.4343
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0014 0.0051 0.0267
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0191 0.0178
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0296 0.1696
Loa Loa (eye worm) RecQ helicase 0.0023 0.0111 0.0379
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0074 0.1389
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000027084 0.00000000014061
Loa Loa (eye worm) solute carrier family 6 member 4 0.0061 0.0374 0.1433
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0142
Leishmania major hypothetical protein, conserved 0.0014 0.0051 0.0556
Brugia malayi hypothetical protein 0.0021 0.0098 0.0428
Onchocerca volvulus 0.0034 0.0191 0.1058
Loa Loa (eye worm) serotonin transporter b 0.0061 0.0374 0.1433
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0191 0.0183
Plasmodium vivax glutathione reductase, putative 0.0051 0.0304 1
Onchocerca volvulus 0.0021 0.0098 0.0495
Entamoeba histolytica hypothetical protein, conserved 0.0369 0.2516 1
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0074 0.1502
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0016 0.0013
Onchocerca volvulus 0.0026 0.0129 0.0683
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0088 0.0077
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0088 0.0077
Onchocerca volvulus 0.0034 0.0191 0.1058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0124
Echinococcus granulosus allatostatin A receptor 0.0034 0.0191 0.0178
Brugia malayi PXA domain containing protein 0.002 0.009 0.0388
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.001 0.0023 0.0042
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.009 0.0079
Brugia malayi Pre-SET motif family protein 0.0217 0.146 0.7557
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0051 0.0267
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0191 0.0711
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0014 0.0051 0.0909
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0129 0.0451
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0262 0.8517
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0088 0.0077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0191 0.0711
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0227 0.7116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0344 0.0332
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0191 0.0914
Onchocerca volvulus 0.0034 0.0191 0.1058
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.009 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0074 0.1389
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0198 0.1342
Plasmodium falciparum glutathione reductase 0.0051 0.0304 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0074 0.6776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0191 0.0711
Schistosoma mansoni amine oxidase 0.0021 0.0098 0.034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0074 0.1389
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0088 0.0378
Schistosoma mansoni amine oxidase 0.0021 0.0098 0.034
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0129 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.002 0.009 0.0467
Brugia malayi Serotonin receptor 0.0034 0.0191 0.0914
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0304 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0172 0.0636
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0069
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0012 0.0033 0.0091
Schistosoma mansoni z-protein (S1r protein) 0.002 0.009 0.0309
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Brugia malayi Dopamine receptor 0.0034 0.0191 0.0914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0451
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0074 0.0091
Plasmodium falciparum transporter, putative 0.001 0.0023 0.0211
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.029 0.7246
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0088 0.0378
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0699
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0088 0.0301
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0191 0.0183
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0098 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0289
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0017 0.0005

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.099 uM Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cells ChEMBL. 21495716
Ki (binding) = 5.3 uM Inhibition of mouse recombinant SPHK2 expressed in baculovirus-infected Sf9 cells ChEMBL. 21495716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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