Detailed information for compound 1563471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.617 | Formula: C24H42N4
  • H donors: 0 H acceptors: 2 LogP: 7.6 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(CCCCCCCCn1cncc1)CCCCCCCCCn1cncc1
  • InChi: 1S/C24H42N4/c1(3-5-7-9-11-13-15-19-27-21-17-25-23-27)2-4-6-8-10-12-14-16-20-28-22-18-26-24-28/h17-18,21-24H,1-16,19-20H2
  • InChiKey: CDRZWEQVRYJCNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.00259482 0.00834779 0.00176084
Schistosoma mansoni hypothetical protein 0.00233207 0.00736503 0.0131769
Echinococcus multilocularis CREB binding protein 0.0130359 0.0474005 0.0861516
Schistosoma mansoni tankyrase 0.0150863 0.0550694 0.0999513
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0130439 0.0474304 0.045284
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0156766 0.0572772 0.548184
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0130439 0.0474304 0.135285
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.00259482 0.00834779 0.00955319
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.147376 0.549873 1
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Schistosoma mansoni neuropeptide f receptor 76f 0.00188031 0.00567533 0.0101033
Toxoplasma gondii ran binding protein 0.00081399 0.00168699 0.00460993
Echinococcus multilocularis serotonin receptor 0.00188031 0.00567533 0.0102658
Schistosoma mansoni biogenic amine receptor 0.00188031 0.00567533 0.0101033
Schistosoma mansoni brg-1 associated factor 0.00233207 0.00736503 0.0131769
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00188031 0.00567533 0.0102658
Trichomonas vaginalis thymidine kinase, putative 0.0227439 0.0837112 0.0925252
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Trichomonas vaginalis thymidylate kinase, putative 0.0202661 0.0744436 0.0822818
Echinococcus granulosus ring and YY1 binding protein 0.00081399 0.00168699 0.00301214
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00188031 0.00567533 0.0102658
Schistosoma mansoni hypothetical protein 0.00233207 0.00736503 0.0131769
Schistosoma mansoni carbonic anhydrase-related 0.0912151 0.339813 0.617901
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.00141229 0.00392481 0.00501503
Loa Loa (eye worm) hypothetical protein 0.00141229 0.00392481 0.00380423
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.00259482 0.00834779 0.00176084
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0308434 0.114006 0.119423
Schistosoma mansoni hypothetical protein 0.00233207 0.00736503 0.0131769
Trypanosoma brucei thymidine kinase 0.0227439 0.0837112 0.149629
Trypanosoma cruzi thymidylate kinase, putative 0.0202661 0.0744436 0.132723
Trypanosoma brucei cytochrome P450, putative 0.00396929 0.0134887 0.0215287
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0772219 0.287474 0.333685
Echinococcus granulosus CREB binding protein 0.0130359 0.0474005 0.0861516
Mycobacterium ulcerans carbonic anhydrase 0.242253 0.904739 1
Trichomonas vaginalis conserved hypothetical protein 0.242253 0.904739 1
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0021248 0.00658978 0.0119289
Echinococcus multilocularis solute carrier family 26, (prestin) 0.000395317 0.000121035 0.000164127
Schistosoma mansoni RNA binding protein 0.00081399 0.00168699 0.00284848
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Leishmania major hypothetical protein, conserved 0.00081399 0.00168699 0.00284848
Onchocerca volvulus 0.0140545 0.0512104 0.16637
Brugia malayi G-protein coupled receptor 0.00188031 0.00567533 0.00732299
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Brugia malayi WGR domain containing protein 0.0021248 0.00658978 0.00852864
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Chlamydia trachomatis sulfate transporter 0.0130439 0.0474304 0.600851
Echinococcus granulosus carbonic anhydrase 0.0912151 0.339813 0.617964
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Plasmodium vivax elongation factor 1-gamma, putative 0.0147495 0.0538099 0.512558
Schistosoma mansoni amine GPCR 0.00188031 0.00567533 0.0101033
Echinococcus granulosus sterile alpha and tir motif containing protein 0.00141229 0.00392481 0.00708206
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0308434 0.114006 0.119423
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00188031 0.00567533 0.0102658
Mycobacterium tuberculosis Hypothetical protein 0.00529759 0.0184569 0.0212923
Echinococcus granulosus neuropeptide Y receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus neuropeptide receptor 0.0129818 0.047198 0.0857833
Trypanosoma brucei elongation factor 1 gamma, putative 0.0147495 0.0538099 0.0950826
Echinococcus multilocularis SWI:SNF matrix associated 0.00233207 0.00736503 0.0133388
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Toxoplasma gondii cytochrome p450 superfamily protein 0.00259482 0.00834779 0.0242183
Echinococcus multilocularis neuropeptide Y receptor 0.00188031 0.00567533 0.0102658
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.00259482 0.00834779 0.0121506
Trichomonas vaginalis thymidylate kinase, putative 0.0202661 0.0744436 0.0822818
Echinococcus multilocularis 0.00259482 0.00834779 0.0151262
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0912151 0.339813 0.447863
Schistosoma mansoni growth hormone secretagogue receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) CBP-B 0.0130359 0.0474005 0.0472852
Schistosoma mansoni TRABID protein (C64 family) 0.00081399 0.00168699 0.00284848
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00188031 0.00567533 0.0101033
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.00233207 0.00736503 0.0213252
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.00081399 0.00168699 0.00206462
Echinococcus granulosus dro:myosuppressin receptor 0.00188031 0.00567533 0.0102658
Mycobacterium tuberculosis Conserved hypothetical protein 0.00217207 0.0067666 0.00771706
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0156766 0.0572772 0.101408
Plasmodium falciparum elongation factor 1-gamma, putative 0.0147495 0.0538099 0.154152
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.00233207 0.00736503 0.0353476
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00188031 0.00567533 0.00732299
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.00259482 0.00834779 0.00955319
Loa Loa (eye worm) hypothetical protein 0.00141229 0.00392481 0.00380423
Echinococcus granulosus g protein coupled receptor 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Echinococcus multilocularis neuropeptide receptor A26 0.00188031 0.00567533 0.0102658
Leishmania major elongation factor-1 gamma 0.0147495 0.0538099 0.0976602
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0147495 0.0538099 0.0978083
Brugia malayi Neurabin protein 1 0.00141229 0.00392481 0.00501503
Schistosoma mansoni thymidylate kinase 0.0202661 0.0744436 0.135193
Loa Loa (eye worm) cytochrome P450 0.00259482 0.00834779 0.00822775
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.00259482 0.00834779 0.00176084
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.00233207 0.00736503 0.0167927
Trypanosoma cruzi thymidylate kinase, putative 0.0202661 0.0744436 0.132723
Echinococcus multilocularis tankyrase 0.015078 0.0550386 0.100043
Onchocerca volvulus Neuropeptide F receptor homolog 0.00188031 0.00567533 0.0133985
Trypanosoma brucei thymidylate kinase, putative 0.0202661 0.0744436 0.132723
Brugia malayi thymidylate kinase 0.0202661 0.0744436 0.0979896
Echinococcus granulosus dihydrofolate reductase 0.00454079 0.0156263 0.0283636
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0111358 0.0402933 0.0986372
Brugia malayi YY1-associated factor 2 0.00081399 0.00168699 0.00206462
Trypanosoma cruzi thymidine kinase, putative 0.0227439 0.0837112 0.149629
Echinococcus granulosus G protein coupled receptor 139 0.00188031 0.00567533 0.0102658
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.00259482 0.00834779 0.00955319
Echinococcus multilocularis ring and YY1 binding protein 0.00081399 0.00168699 0.00301214
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi UDP-galactopyranose mutase 0.00217207 0.0067666 0.00926622
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00188031 0.00567533 0.0102658
Schistosoma mansoni adenoreceptor 0.00188031 0.00567533 0.0101033
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.00259482 0.00834779 0.00955319
Schistosoma mansoni opsin-like receptor 0.00188031 0.00567533 0.0101033
Echinococcus granulosus sex peptide receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00188031 0.00567533 0.00732299
Echinococcus granulosus 7tm_1 domain containing protein 0.00188031 0.00567533 0.0102658
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.00259482 0.00834779 0.00955319
Echinococcus multilocularis neuropeptides capa receptor 0.00188031 0.00567533 0.0102658
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0912151 0.339813 0.447863
Echinococcus multilocularis glutathione S transferase 0.0647923 0.240984 0.438223
Echinococcus granulosus solute carrier family 26 0.000395317 0.000121035 0.000164127
Brugia malayi Putative carbonic anhydrase 5 precursor 0.147376 0.549873 0.724813
Echinococcus multilocularis G-protein coupled receptor, putative 0.00188031 0.00567533 0.0102658
Brugia malayi Cytochrome P450 family protein 0.00563205 0.0197079 0.0258241
Echinococcus granulosus liprin beta 1 0.00141229 0.00392481 0.00708206
Echinococcus granulosus glutathione s transferase mu 0.0752977 0.280277 0.509686
Echinococcus granulosus glutathione S transferase 0.00424418 0.0145169 0.0263459
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Plasmodium falciparum tyrosine kinase-like protein 0.00141229 0.00392481 0.00661828
Brugia malayi larval opioid receptor 0.00188031 0.00567533 0.00732299
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0202661 0.0744436 0.199109
Echinococcus multilocularis liprin alpha 2 0.00141229 0.00392481 0.00708206
Schistosoma mansoni hypothetical protein 0.00141229 0.00392481 0.00691907
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Schistosoma mansoni hypothetical protein 0.00141229 0.00392481 0.00691907
Echinococcus granulosus tm gpcr rhodopsin 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.00259482 0.00834779 0.00176084
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.00259482 0.00834779 0.00955319
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.00259482 0.00834779 0.00955319
Schistosoma mansoni opsin-like receptor 0.00188031 0.00567533 0.0101033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00188031 0.00567533 0.0101033
Mycobacterium ulcerans integral membrane transporter 0.0130439 0.0474304 0.045284
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00188031 0.00567533 0.00555497
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.00259482 0.00834779 0.00955319
Schistosoma mansoni carbonic anhydrase-related 0.0912151 0.339813 0.617901
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.00454079 0.0156263 0.0260656
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.00081399 0.00168699 0.00460993
Leishmania major hypothetical protein, conserved 0.00081399 0.00168699 0.00284848
Schistosoma mansoni hypothetical protein 0.0912151 0.339813 0.617901
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00396929 0.0134887 0.00748586
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.00233207 0.00736503 0.00724487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) thymidylate kinase 0.0202661 0.0744436 0.0743316
Loa Loa (eye worm) hypothetical protein 0.00081399 0.00168699 0.00156615
Trichomonas vaginalis conserved hypothetical protein 0.00141229 0.00392481 0.00433805
Brugia malayi Cytochrome P450 family protein 0.00259482 0.00834779 0.0108465
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Loa Loa (eye worm) cytochrome P450 family protein 0.00396929 0.0134887 0.0133693
Echinococcus multilocularis serotonin receptor 0.00188031 0.00567533 0.0102658
Schistosoma mansoni amine GPCR 0.00188031 0.00567533 0.0101033
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00188031 0.00567533 0.00555497
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0169279 0.0619575 0.068481
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Schistosoma mansoni carbonic anhydrase-related 0.0912151 0.339813 0.617901
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.00259482 0.00834779 0.00176084
Loa Loa (eye worm) hypothetical protein 0.00137447 0.00378334 0.00366275
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.00259482 0.00834779 0.00955319
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.00217207 0.0067666 0.0150228
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.00081399 0.00168699 0.00301214
Brugia malayi Liprin-alpha 2 0.00141229 0.00392481 0.00501503
Schistosoma mansoni amine GPCR 0.00188031 0.00567533 0.0101033
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.00259482 0.00834779 0.00955319
Schistosoma mansoni alpha-1 adrenergic receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) cytochrome P450 family protein 0.00563205 0.0197079 0.0195893
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Brugia malayi Cytochrome P450 family protein 0.00396929 0.0134887 0.0176244
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Schistosoma mansoni carbonic anhydrase 0.0888428 0.33094 0.601761
Echinococcus multilocularis glutathione S transferase 0.0752977 0.280277 0.509686
Echinococcus granulosus prostaglandin H2 D isomerase 0.0274332 0.10125 0.184089
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021248 0.00658978 0.00894367
Onchocerca volvulus Putative sulfate transporter 0.0803988 0.299357 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) hypothetical protein 0.00141229 0.00392481 0.00380423
Echinococcus multilocularis neuropeptide s receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus glutathione S transferase 0.0583698 0.216962 0.394534
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.00259482 0.00834779 0.00176084
Brugia malayi Melatonin receptor type 1A 0.00188031 0.00567533 0.00732299
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.00217207 0.0067666 0.0150228
Onchocerca volvulus Putative thymidylate kinase 0.0202661 0.0744436 0.244421
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0202661 0.0744436 0.0863059
Loa Loa (eye worm) tnks protein 0.0136706 0.0497745 0.0496594
Mycobacterium ulcerans thymidylate kinase 0.0202661 0.0744436 0.0753664
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.00259482 0.00834779 0.00955319
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021248 0.00658978 0.0117667
Echinococcus granulosus glutathione S transferase Mu 1 0.0274332 0.10125 0.184089
Trypanosoma brucei thymidylate kinase, putative 0.0202661 0.0744436 0.132723
Schistosoma mansoni thymidylate kinase 0.0202661 0.0744436 0.135193
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Trichomonas vaginalis conserved hypothetical protein 0.242253 0.904739 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.00259482 0.00834779 0.00176084
Onchocerca volvulus 0.00233207 0.00736503 0.019075
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0912151 0.339813 0.447863
Plasmodium falciparum glutathione S-transferase 0.0752977 0.280277 0.823925
Entamoeba histolytica thymidine kinase, putative 0.0227439 0.0837112 0.237772
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Echinococcus granulosus CREB binding protein 0.0130359 0.0474005 0.0861516
Schistosoma mansoni dihydrofolate reductase 0.00454079 0.0156263 0.0282041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00188031 0.00567533 0.0101033
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021248 0.00658978 0.019043
Echinococcus granulosus stringent starvation protein A 0.00424418 0.0145169 0.0263459
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.00259482 0.00834779 0.00176084
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.00233207 0.00736503 0.0213252
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Echinococcus granulosus alpha 1A adrenergic receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus Sterile alpha motif SAM 0.00141229 0.00392481 0.00708207
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.00259482 0.00834779 0.00176084
Brugia malayi Dopamine receptor protein 2 0.00188031 0.00567533 0.00732299
Echinococcus multilocularis 0.00217207 0.0067666 0.0122505
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00188031 0.00567533 0.0102658
Schistosoma mansoni neuropeptide F-like receptor 0.00188031 0.00567533 0.0101033
Echinococcus granulosus Upstream activation factor subunit UAF30 0.00233207 0.00736503 0.0133388
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.00259482 0.00834779 0.00955319
Echinococcus multilocularis glutathione S transferase 0.00424418 0.0145169 0.0263459
Echinococcus multilocularis neuropeptides capa receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus Nuclear pore complex protein Nup153 0.00081399 0.00168699 0.00301214
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.00141229 0.00392481 0.00708206
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0156766 0.0572772 0.101408
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Toxoplasma gondii thymidylate kinase 0.0202661 0.0744436 0.218794
Schistosoma mansoni cellular tumor antigen P53 0.0140545 0.0512104 0.0929317
Echinococcus multilocularis g protein coupled receptor 0.00188031 0.00567533 0.0102658
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0202661 0.0744436 1
Echinococcus multilocularis neuropeptide receptor 0.0129818 0.047198 0.0857833
Echinococcus granulosus neuropeptide receptor 0.00188031 0.00567533 0.0102658
Leishmania major hypothetical protein, conserved 0.0105054 0.0379354 0.0687846
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.0169279 0.0619575 0.202474
Brugia malayi neuropeptide F receptor 0.00188031 0.00567533 0.00732299
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis thymidylate kinase 0.0202661 0.0744436 0.135335
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis SWI:SNF matrix associated 0.00233207 0.00736503 0.0133388
Schistosoma mansoni sarm1 0.00141229 0.00392481 0.00691907
Trichomonas vaginalis conserved hypothetical protein 0.00233207 0.00736503 0.0081405
Echinococcus granulosus thymidylate kinase 0.0202661 0.0744436 0.135335
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021248 0.00658978 0.0117667
Echinococcus multilocularis lysine specific histone demethylase 1A 0.00217207 0.0067666 0.0122505
Echinococcus granulosus neuropeptide receptor A26 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis fmrfamide receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.147376 0.549873 0.724813
Plasmodium vivax hypothetical protein, conserved 0.00233207 0.00736503 0.0353476
Trichomonas vaginalis conserved hypothetical protein 0.00424418 0.0145169 0.0160454
Brugia malayi follicle stimulating hormone receptor 0.00188031 0.00567533 0.00732299
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Mycobacterium leprae Probable transmembrane transport protein 0.0930474 0.346666 1
Brugia malayi Serotonin receptor 0.00188031 0.00567533 0.00732299
Trichomonas vaginalis conserved hypothetical protein 0.00141229 0.00392481 0.00433805
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Leishmania major cytochrome p450-like protein 0.00396929 0.0134887 0.0243158
Echinococcus granulosus poly adp ribose polymerase 2 0.0021248 0.00658978 0.0119289
Echinococcus granulosus biogenic amine 5HT receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.0912151 0.339813 0.339733
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.00804272 0.0287245 0.0493218
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni CREB-binding protein 2 0.0130359 0.0474005 0.0860016
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0130359 0.0474005 0.0860016
Schistosoma mansoni zinc finger protein 0.00081399 0.00168699 0.00284848
Loa Loa (eye worm) hypothetical protein 0.0021248 0.00658978 0.00646953
Mycobacterium ulcerans thymidylate synthase 0.0111358 0.0402933 0.037336
Brugia malayi Cytochrome P450 family protein 0.00396929 0.0134887 0.0176244
Echinococcus granulosus glutathione S transferase 0.0583698 0.216962 0.394534
Trypanosoma cruzi cytochrome P450, putative 0.00396929 0.0134887 0.0215287
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Echinococcus granulosus cytochrome P450 2K1 0.00259482 0.00834779 0.0151262
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00188031 0.00567533 0.00732299
Leishmania major cytochrome p450-like protein 0.00259482 0.00834779 0.0149645
Plasmodium falciparum thymidylate kinase 0.0202661 0.0744436 0.215176
Leishmania major elongation factor 1-gamma, putative 0.0147495 0.0538099 0.0976602
Schistosoma mansoni biogenic amine receptor 0.00188031 0.00567533 0.0101033
Schistosoma mansoni hypothetical protein 0.00141229 0.00392481 0.00691907
Schistosoma mansoni histamine h1 receptor 0.00188031 0.00567533 0.0101033
Schistosoma mansoni biogenic amine (5HT) receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.147376 0.549873 0.549818
Echinococcus granulosus poly ADP ribose polymerase 1 0.0021248 0.00658978 0.0119289
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.00259482 0.00834779 0.00955319
Brugia malayi glutathione transferase 0.20318 0.758595 1
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Schistosoma mansoni amine oxidase 0.00217207 0.0067666 0.0120883
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0156766 0.0572772 0.103967
Echinococcus multilocularis g protein coupled receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus tankyrase 0.015078 0.0550386 0.100043
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus orexin receptor type 2 0.00188031 0.00567533 0.0102658
Echinococcus granulosus solute carrier family 26 prestin 0.000395317 0.000121035 0.000164127
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Echinococcus granulosus neuropeptide s receptor 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.00259482 0.00834779 0.00176084
Brugia malayi brahma associated protein 60 kDa 0.00233207 0.00736503 0.00955075
Brugia malayi hypothetical protein 0.00424418 0.0145169 0.01898
Toxoplasma gondii elongation factor 1-gamma, putative 0.0147495 0.0538099 0.158052
Echinococcus granulosus liprin alpha 2 0.00141229 0.00392481 0.00708206
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00188031 0.00567533 0.0102658
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis protoporphyrinogen oxidase 0.00217207 0.0067666 0.0122505
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.00233207 0.00736503 0.0167927
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Brugia malayi Glutathione S-transferase 4 0.0169279 0.0619575 0.0815275
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.000505348 0.000532581 0.000588657
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.00259482 0.00834779 0.00176084
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00188031 0.00567533 0.0101033
Schistosoma mansoni neuropeptide F-like receptor 0.00188031 0.00567533 0.0101033
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.00259482 0.00834779 0.00955319
Echinococcus multilocularis sex peptide receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Toxoplasma gondii histone lysine-specific demethylase 0.00217207 0.0067666 0.0195635
Plasmodium vivax sulfate transporter, putative 0.0130439 0.0474304 0.447011
Echinococcus granulosus neuropeptide Y receptor 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.00259482 0.00834779 0.00176084
Schistosoma mansoni hypothetical protein 0.00188031 0.00567533 0.0101033
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Mycobacterium ulcerans carbonic anhydrase 0.0888428 0.33094 0.361006
Mycobacterium leprae Conserved hypothetical protein 0.00259482 0.00834779 0.00465193
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.267722 1 1
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) neuropeptide F receptor 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis orexin receptor type 2 0.00188031 0.00567533 0.0102658
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.00259482 0.00834779 0.0121506
Brugia malayi Serotonin receptor 0.00188031 0.00567533 0.00732299
Echinococcus granulosus somatostatin receptor 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0021248 0.00658978 0.0119289
Trypanosoma brucei poly(adp-ribose) polymerase 0.0021248 0.00658978 0.00894367
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.00259482 0.00834779 0.00955319
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Plasmodium vivax hypothetical protein, conserved 0.00217207 0.0067666 0.0291988
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00188031 0.00567533 0.00555497
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Brugia malayi AKH receptor 0.00188031 0.00567533 0.00732299
Echinococcus multilocularis glutathione S transferase 0.0583698 0.216962 0.394534
Giardia lamblia CDC8 0.0202661 0.0744436 0.866064
Echinococcus multilocularis SAM domain containing protein 0.00141229 0.00392481 0.00708206
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.00141229 0.00392481 0.0111977
Loa Loa (eye worm) thymidylate synthase 0.0111358 0.0402933 0.0401772
Schistosoma mansoni neuropeptide receptor 0.00188031 0.00567533 0.0101033
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.00804272 0.0287245 0.0493218
Brugia malayi brahma associated protein 60 kDa 0.00233207 0.00736503 0.00955075
Schistosoma mansoni neuropeptide receptor 0.0129818 0.047198 0.0856333
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Loa Loa (eye worm) hypothetical protein 0.0912151 0.339813 0.339733
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0111358 0.0402933 0.0730736
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.00424418 0.0145169 0.01898
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0111358 0.0402933 0.0466495
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Echinococcus multilocularis allatostatin A receptor 0.00188031 0.00567533 0.0102658
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00188031 0.00567533 0.0133985
Loa Loa (eye worm) hypothetical protein 0.00141229 0.00392481 0.00380423
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00188031 0.00567533 0.0101033
Echinococcus multilocularis fmrfamide receptor 0.00188031 0.00567533 0.0102658
Mycobacterium leprae putative cytochrome p450 0.00259482 0.00834779 0.00465193
Toxoplasma gondii hypothetical protein 0.0912151 0.339813 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Echinococcus granulosus 7TM GPCR rhodopsin 0.00188031 0.00567533 0.0102658
Schistosoma mansoni amine oxidase 0.00217207 0.0067666 0.0120883
Schistosoma mansoni lar interacting protein (lip)-related protein 0.00141229 0.00392481 0.00691907
Echinococcus granulosus glutathione S transferase 0.0752977 0.280277 0.509686
Trypanosoma cruzi cytochrome P450, putative 0.00396929 0.0134887 0.0215287
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0130439 0.0474304 0.139271
Trichomonas vaginalis thymidine kinase, putative 0.0227439 0.0837112 0.0925252
Echinococcus granulosus g-protein coupled receptor 0.00188031 0.00567533 0.0102658
Plasmodium falciparum carbonic anhydrase 0.0912151 0.339813 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0888428 0.33094 0.953733
Echinococcus multilocularis solute carrier family 26 0.000395317 0.000121035 0.000164127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Schistosoma mansoni hypothetical protein 0.0202661 0.0744436 0.135193
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Trichomonas vaginalis conserved hypothetical protein 0.00529759 0.0184569 0.0204003
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni cytochrome P450 0.00259482 0.00834779 0.0149645
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Brugia malayi putative neuropeptide receptor NPR1 0.00188031 0.00567533 0.00732299
Echinococcus granulosus tachykinin peptides receptor 99D 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) neuropeptide F receptor 0.00188031 0.00567533 0.00555497
Brugia malayi amine oxidase, flavin-containing family protein 0.00217207 0.0067666 0.00876176
Brugia malayi coiled-coil like protein 1 0.00141229 0.00392481 0.00501503
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0147495 0.0538099 0.0978083
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.000497116 0.00050179 0.000554624
Echinococcus granulosus neuropeptides capa receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus SWI:SNF matrix associated 0.00233207 0.00736503 0.0133388
Echinococcus granulosus tm gpcr rhodopsin 0.00188031 0.00567533 0.0102658
Onchocerca volvulus 0.00217207 0.0067666 0.0170646
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.00259482 0.00834779 0.00176084
Echinococcus multilocularis carbonic anhydrase 0.0912151 0.339813 0.617964
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.147376 0.549873 1
Echinococcus multilocularis zinc finger protein Ran binding 0.00081399 0.00168699 0.00301214
Chlamydia trachomatis SWIB complex protein 0.00233207 0.00736503 0.00884244
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0912151 0.339813 0.447863
Echinococcus multilocularis glutathione S transferase 0.0274332 0.10125 0.184089
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.00259482 0.00834779 0.00176084
Leishmania major carbonic anhydrase family protein, putative 0.0888428 0.33094 0.601761
Loa Loa (eye worm) G-protein coupled receptor 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis glutathione S-transferase 0.0752977 0.280277 0.509686
Echinococcus multilocularis SWI:SNF matrix associated 0.00233207 0.00736503 0.0133388
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Schistosoma mansoni amine GPCR 0.00188031 0.00567533 0.0101033
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.00259482 0.00834779 0.0121506
Echinococcus granulosus g protein coupled receptor 0.00188031 0.00567533 0.0102658
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.00141229 0.00392481 0.00380423
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Echinococcus granulosus Zinc finger RanBP2 type 0.00081399 0.00168699 0.00301214
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.00454079 0.0156263 0.00986634
Echinococcus granulosus lysine specific histone demethylase 1A 0.00217207 0.0067666 0.0122505
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Echinococcus granulosus fmrfamide receptor 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00081399 0.00168699 0.00156615
Echinococcus multilocularis thymidylate synthase 0.0111358 0.0402933 0.0732257
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0130439 0.0474304 0.0834452
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Brugia malayi Tnks protein 0.0149636 0.0546107 0.0718412
Chlamydia trachomatis DNA topoisomerase I 0.00233207 0.00736503 0.00884244
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0156766 0.0572772 0.168259
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0021248 0.00658978 0.00646953
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021248 0.00658978 0.00894367
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni carbonic anhydrase 0.0912151 0.339813 0.617901
Leishmania major cytochrome p450-like protein 0.00259482 0.00834779 0.0149645
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.00259482 0.00834779 0.00176084
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0130439 0.0474304 0.045284
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00188031 0.00567533 0.0102658
Brugia malayi WGR domain containing protein 0.0021248 0.00658978 0.00852864
Brugia malayi hypothetical protein 0.00141229 0.00392481 0.00501503
Echinococcus multilocularis somatostatin receptor 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis glutathione s transferase mu 0.0752977 0.280277 0.509686
Echinococcus granulosus glutathione S transferase 0.0169279 0.0619575 0.112626
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Brugia malayi sulfakinin receptor protein 0.00188031 0.00567533 0.00732299
Loa Loa (eye worm) hypothetical protein 0.00424418 0.0145169 0.0143976
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0105054 0.0379354 0.0661244
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00188031 0.00567533 0.00732299
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.0140545 0.0512104 0.0510955
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi UDP-galactopyranose mutase 0.00217207 0.0067666 0.00926622
Loa Loa (eye worm) hypothetical protein 0.00081399 0.00168699 0.00156615
Onchocerca volvulus 0.0111358 0.0402933 0.129695
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Plasmodium vivax glutathione S-transferase, putative 0.0274332 0.10125 1
Trypanosoma brucei hypothetical protein, conserved 0.0105054 0.0379354 0.0661244
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.00259482 0.00834779 0.00176084
Echinococcus multilocularis stromal interaction molecule 1 0.00141229 0.00392481 0.00708206
Loa Loa (eye worm) hypothetical protein 0.0112393 0.0406806 0.0405645
Leishmania major hypothetical protein, conserved 0.00081399 0.00168699 0.00284848
Entamoeba histolytica Thymidylate kinase, putative 0.0202661 0.0744436 0.209199
Brugia malayi Tachykinin-like peptides receptor 99D 0.00188031 0.00567533 0.00732299
Loa Loa (eye worm) melatonin receptor type 1A 0.00188031 0.00567533 0.00555497
Echinococcus granulosus SAM domain containing protein 0.00141229 0.00392481 0.00708206
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00188031 0.00567533 0.0102658
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.104668 0.390132 0.452894
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni hypothetical protein 0.00188031 0.00567533 0.0101033
Brugia malayi putative neuropeptide receptor 0.00188031 0.00567533 0.00732299
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) carbonic anhydrase 3 0.147376 0.549873 0.549818
Echinococcus granulosus hypothetical protein 0.00188031 0.00567533 0.0102658
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.00081399 0.00168699 0.00206462
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.00259482 0.00834779 0.00955319
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0912151 0.339813 0.339733
Trichomonas vaginalis thymidine kinase, putative 0.0227439 0.0837112 0.0925252
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0130439 0.0474304 0.0834452
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Plasmodium vivax protoporphyrinogen oxidase, putative 0.00217207 0.0067666 0.0291988
Schistosoma mansoni fusion 0.00081399 0.00168699 0.00284848
Plasmodium falciparum protein kinase, putative 0.00141229 0.00392481 0.00661828
Onchocerca volvulus 0.0803988 0.299357 1
Schistosoma mansoni hypothetical protein 0.00188031 0.00567533 0.0101033
Echinococcus multilocularis glutathione S transferase 0.0752977 0.280277 0.509686
Brugia malayi hypothetical protein 0.00217207 0.0067666 0.00876176
Schistosoma mansoni hypothetical protein 0.00081399 0.00168699 0.00284848
Schistosoma mansoni Lysine-specific histone demethylase 1 0.00217207 0.0067666 0.0120883
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00188031 0.00567533 0.0101033
Onchocerca volvulus 0.00141229 0.00392481 0.00751777
Schistosoma mansoni hypothetical protein 0.00259482 0.00834779 0.0149645
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Trypanosoma cruzi thymidine kinase, putative 0.0227439 0.0837112 0.149629
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00188031 0.00567533 0.0101033
Echinococcus multilocularis neuropeptide Y receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus allatostatin A receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus carbonic anhydrase 0.0912151 0.339813 0.617964
Entamoeba histolytica carbonic anhydrase, putative 0.0888428 0.33094 1
Brugia malayi hypothetical protein 0.00529759 0.0184569 0.0241747
Echinococcus multilocularis dihydrofolate reductase 0.00454079 0.0156263 0.0283636
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.00259482 0.00834779 0.00955319
Loa Loa (eye worm) G-protein coupled receptor 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.20318 0.758595 0.758565
Brugia malayi hypothetical protein 0.00141229 0.00392481 0.00501503
Echinococcus granulosus biogenic amine 5HT receptor 0.00188031 0.00567533 0.0102658
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0130439 0.0474304 0.0834452
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.00454079 0.0156263 0.0180053
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.00529759 0.0184569 0.0305918
Loa Loa (eye worm) hypothetical protein 0.0169279 0.0619575 0.0618439
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00188031 0.00567533 0.0101033
Brugia malayi SWIB/MDM2 domain containing protein 0.00233207 0.00736503 0.00955075
Schistosoma mansoni elongation factor 1-gamma 0.0147495 0.0538099 0.0976602
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Schistosoma mansoni neuropeptide receptor 0.00188031 0.00567533 0.0101033
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0021248 0.00658978 0.0119289
Schistosoma mansoni amine GPCR 0.00188031 0.00567533 0.0101033
Leishmania major hypothetical protein, conserved 0.00081399 0.00168699 0.00284848
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.00259482 0.00834779 0.00176084
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.147376 0.549873 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Brugia malayi G protein-coupled receptor F59B2.13 0.00188031 0.00567533 0.00732299
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Brugia malayi TAZ zinc finger family protein 0.0130359 0.0474005 0.062335
Treponema pallidum thymidylate kinase (tmk) 0.0202661 0.0744436 0.5
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0147495 0.0538099 0.0950826
Leishmania major hypothetical protein, conserved 0.00804272 0.0287245 0.0520298
Trypanosoma brucei carbonic anhydrase-like protein 0.147376 0.549873 1
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Echinococcus granulosus peptide allatostatin:somatostatin 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis G protein coupled receptor 139 0.0129818 0.047198 0.0857833
Leishmania major lanosterol 14-alpha-demethylase, putative 0.00259482 0.00834779 0.0149645
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00188031 0.00567533 0.0101033
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Loa Loa (eye worm) brahma associated protein 0.00233207 0.00736503 0.00724487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00188031 0.00567533 0.0101033
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.00081399 0.00168699 0.00206462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00188031 0.00567533 0.00732299
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0274332 0.10125 0.183955
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.00217207 0.0067666 0.0291988
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Echinococcus multilocularis Zinc finger, RanBP2 type 0.00081399 0.00168699 0.00301214
Echinococcus multilocularis tumor protein p63 0.0944903 0.352063 0.640243
Brugia malayi ORL1-like opioid receptor 0.00188031 0.00567533 0.00732299
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.147376 0.549873 1
Giardia lamblia Thymidine kinase 0.0227439 0.0837112 1
Onchocerca volvulus Tankyrase homolog 0.0133559 0.0485972 0.157592
Plasmodium falciparum protoporphyrinogen oxidase 0.00217207 0.0067666 0.0150228
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0912151 0.339813 0.447863
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.230632 0.861274 1
Echinococcus multilocularis neuropeptide receptor 0.00188031 0.00567533 0.0102658
Brugia malayi cytochrome P450 0.00259482 0.00834779 0.0108465
Echinococcus granulosus serotonin receptor 0.00188031 0.00567533 0.0102658
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.00081399 0.00168699 0.00206462
Schistosoma mansoni biogenic amine receptor 0.00188031 0.00567533 0.0101033
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Echinococcus multilocularis rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis carbonic anhydrase 0.0912151 0.339813 0.617964
Mycobacterium tuberculosis Possible oxidoreductase 0.00217207 0.0067666 0.00771706
Echinococcus granulosus neuropeptides capa receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus zinc finger protein Ran binding 0.00081399 0.00168699 0.00301214
Schistosoma mansoni myosin xvIII 0.00188031 0.00567533 0.0101033
Schistosoma mansoni opsin-like receptor 0.00188031 0.00567533 0.0101033
Brugia malayi SWIRM domain containing protein 0.00217207 0.0067666 0.00876176
Loa Loa (eye worm) hypothetical protein 0.00081399 0.00168699 0.00156615
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Loa Loa (eye worm) TYRA-2 protein 0.00188031 0.00567533 0.00555497
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.00233207 0.00736503 0.0133388
Plasmodium vivax thymidylate kinase, putative 0.0202661 0.0744436 0.724565
Schistosoma mansoni hypothetical protein 0.00188031 0.00567533 0.0101033
Brugia malayi neuropeptide F receptor 0.00188031 0.00567533 0.00732299
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Plasmodium vivax hypothetical protein, conserved 0.00217207 0.0067666 0.0291988
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Loa Loa (eye worm) hypothetical protein 0.00081399 0.00168699 0.00156615
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Leishmania major thymidylate kinase-like protein 0.0202661 0.0744436 0.135193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Echinococcus multilocularis neuropeptide FF receptor 2 0.00188031 0.00567533 0.0102658
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Chlamydia trachomatis thymidylate kinase 0.0202661 0.0744436 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.00259482 0.00834779 0.00955319
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Echinococcus granulosus g protein coupled receptor 0.00188031 0.00567533 0.0102658
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.00424418 0.0145169 0.01898
Trichomonas vaginalis conserved hypothetical protein 0.0021248 0.00658978 0.00728363
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis carbonic anhydrase II 0.147376 0.549873 1
Schistosoma mansoni neuropeptide receptor 0.00188031 0.00567533 0.0101033
Chlamydia trachomatis dihydrofolate reductase 0.00454079 0.0156263 0.130911
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0286713 0.105881 0.122813
Echinococcus granulosus stromal interaction molecule 1 0.00141229 0.00392481 0.00708206
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0930474 0.346666 0.40242
Trypanosoma cruzi cytochrome p450-like protein, putative 0.00259482 0.00834779 0.0121506
Echinococcus multilocularis carbonic anhydrase 0.0912151 0.339813 0.617964
Loa Loa (eye worm) hypothetical protein 0.00217207 0.0067666 0.00664637
Loa Loa (eye worm) dihydrofolate reductase 0.00454079 0.0156263 0.0155071
Trichomonas vaginalis conserved hypothetical protein 0.00141229 0.00392481 0.00433805
Leishmania major carbonic anhydrase-like protein 0.147376 0.549873 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00188031 0.00567533 0.0102658
Brugia malayi dihydrofolate reductase family protein 0.00454079 0.0156263 0.0204427
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00188031 0.00567533 0.0102658
Brugia malayi Dopamine receptor 0.00188031 0.00567533 0.00732299
Brugia malayi Dopamine receptor protein 1 0.00188031 0.00567533 0.00732299
Echinococcus multilocularis glutathione S transferase 0.0647923 0.240984 0.438223
Trichomonas vaginalis conserved hypothetical protein 0.00141229 0.00392481 0.00433805
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Onchocerca volvulus 0.00424418 0.0145169 0.0431011
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.00259482 0.00834779 0.00176084
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.00141229 0.00392481 0.00433805
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.00217207 0.0067666 0.0195635
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.00259482 0.00834779 0.00176084
Trypanosoma brucei elongation factor 1 gamma, putative 0.0147495 0.0538099 0.0950826
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.00259482 0.00834779 0.00955319
Leishmania major thymidine kinase, putative 0.0227439 0.0837112 0.152051
Schistosoma mansoni hypothetical protein 0.00141229 0.00392481 0.00691907
Echinococcus multilocularis liprin beta 1 0.00141229 0.00392481 0.00708206
Brugia malayi Dihydrofolate reductase 0.00454079 0.0156263 0.0204427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00188031 0.00567533 0.0101033
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.00259482 0.00834779 0.00176084
Echinococcus multilocularis g protein coupled receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus lysine specific histone demethylase 1A 0.00217207 0.0067666 0.0122505
Brugia malayi GnHR receptor homolog 0.00188031 0.00567533 0.00732299
Loa Loa (eye worm) cytochrome P450 family protein 0.00396929 0.0134887 0.0133693
Loa Loa (eye worm) hypothetical protein 0.00141229 0.00392481 0.00380423
Onchocerca volvulus 0.00188031 0.00567533 0.0133985
Loa Loa (eye worm) CYP4Cod1 0.00396929 0.0134887 0.0133693
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.00217207 0.0067666 0.0120883
Schistosoma mansoni glutathione-S-transferase 0.0752977 0.280277 0.509605
Echinococcus granulosus thymidylate synthase 0.0111358 0.0402933 0.0732257
Echinococcus granulosus tm gpcr rhodopsin 0.00188031 0.00567533 0.0102658
Brugia malayi G protein-coupled receptor 0.00188031 0.00567533 0.00732299
Leishmania major UDP-galactopyranose mutase 0.00217207 0.0067666 0.0120883
Schistosoma mansoni lip-related protein (liprin) alpha 0.00141229 0.00392481 0.00691907
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0274332 0.10125 0.184089
Echinococcus granulosus carbonic anhydrase II 0.147376 0.549873 1
Schistosoma mansoni GST class-mu 0.0752977 0.280277 0.509605
Brugia malayi G-protein coupled receptor 0.00188031 0.00567533 0.00732299
Leishmania major hypothetical protein, conserved 0.00081399 0.00168699 0.00284848
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00188031 0.00567533 0.0101033
Brugia malayi RE15519p 0.00188031 0.00567533 0.00732299
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.000493761 0.000489244 0.000540757
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0156766 0.0572772 0.164407
Loa Loa (eye worm) hypothetical protein 0.00188031 0.00567533 0.00555497
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Echinococcus granulosus neuropeptide FF receptor 2 0.00188031 0.00567533 0.0102658
Echinococcus multilocularis g-protein coupled receptor 0.00188031 0.00567533 0.0102658
Echinococcus granulosus carbonic anhydrase 0.0912151 0.339813 0.617964
Echinococcus multilocularis glutathione S transferase 0.0583698 0.216962 0.394534
Echinococcus granulosus rhodopsin orphan GPCR 0.00188031 0.00567533 0.0102658
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.00259482 0.00834779 0.00955319
Echinococcus granulosus tumor protein p63 0.0944903 0.352063 0.640243
Onchocerca volvulus 0.00141229 0.00392481 0.00751777
Brugia malayi hypothetical protein 0.00188031 0.00567533 0.00732299
Brugia malayi thymidylate synthase 0.0111358 0.0402933 0.0529647

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.4 uM Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of parasite LDH activity after 72 hrs ChEMBL. 21944972

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21944972

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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