Detailed information for compound 1564357

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 552.619 | Formula: C28H34F2N8O2
  • H donors: 1 H acceptors: 4 LogP: 2.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(c(c1)F)C(Cn1ncnc1)(CN1CCN(CC1)CCCn1ncn(c1=O)c1cc(C)cc(c1)C)O
  • InChi: 1S/C28H34F2N8O2/c1-21-12-22(2)14-24(13-21)37-20-33-38(27(37)39)7-3-6-34-8-10-35(11-9-34)16-28(40,17-36-19-31-18-32-36)25-5-4-23(29)15-26(25)30/h4-5,12-15,18-20,40H,3,6-11,16-17H2,1-2H3
  • InChiKey: HNRUFVQGNPGUOA-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.2434 0.2434
Trypanosoma cruzi short chain dehydrogenase, putative 0.0004 0.0002 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Brugia malayi Dehydrogenases, short chain protein 2 0.0004 0.0002 0.0004
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0004 0.0002 0.0043
Trypanosoma brucei oxidoreductase-like protein 0.0004 0.0002 0.0043
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.1592 0.1592
Brugia malayi dehydrogenases, short chain protein 9 0.0004 0.0002 0.0004
Leishmania major hypothetical protein, conserved 0.0004 0.0002 0.0004
Giardia lamblia Hypothetical protein 0.0004 0.0002 0.0004
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0004 0.0002 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0004 0.0002 0.0043
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0186 0.4481 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0186 0.4481 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0004 0.0002 0.0043
Brugia malayi Dehydrogenases, short chain protein 30 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Toxoplasma gondii carbonyl reductase 1, putative 0.0004 0.0002 0.0004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.2434 0.2434
Brugia malayi hypothetical protein 0.0004 0.0002 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0149
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0004 0.0002 0.0002
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.037 0.0827
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.2434 0.2434
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0004 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.037 1
Onchocerca volvulus 0.0029 0.0615 1
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0004 0.0002 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0002 0.0002
Plasmodium falciparum macrophage migration inhibitory factor 0.0186 0.4481 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0126 0.028
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0004 0.0002 0.0043
Toxoplasma gondii oxidoreductase, putative 0.0004 0.0002 0.0004
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.0002 0.0002
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0004 0.0002 0.0043
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0004 0.0002 0.0026
Echinococcus multilocularis dnaJ subfamily B 0.041 1 1
Schistosoma mansoni retinal dehydrogenase 0.0004 0.0002 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.037 0.0827
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0004 0.0002 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0126 0.0126
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0004 0.0002 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Leishmania major macrophage migration inhibitory factor-like protein 0.0186 0.4481 1
Brugia malayi hypothetical protein 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0008 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0004 0.0002 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Onchocerca volvulus 0.0004 0.0002 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0004 0.0002 0.0004
Echinococcus granulosus hypothetical protein 0.0004 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0004 0.0002 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0004 0.0002 0.0043
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0004 0.0002 0.0043
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Toxoplasma gondii melibiase subfamily protein 0.0103 0.2434 0.5432
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0082 0.0082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.037 0.0827
Brugia malayi Melibiase family protein 0.0068 0.1592 0.3552
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.037 1
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0186 0.4481 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.0002 0.0002
Onchocerca volvulus 0.0004 0.0002 0.0026
Onchocerca volvulus 0.0004 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Trypanosoma cruzi short chain dehydrogenase, putative 0.0004 0.0002 0.0043
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0004 0.0002 0.0043
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.2434 0.2434
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0004 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Echinococcus granulosus hypothetical protein 0.0004 0.0002 0.0002
Plasmodium vivax steroid dehydrogenase, putative 0.0004 0.0002 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0004 0.0002 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.037 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Brugia malayi oxidoreductase 0.0004 0.0002 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Trichomonas vaginalis steroid dehydrogenase, putative 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Echinococcus granulosus steroid dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Leishmania major 3-keto-dihydrosphingosine reductase 0.0004 0.0002 0.0004
Leishmania major macrophage migration inhibitory factor-like protein 0.0186 0.4481 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Brugia malayi dehydrogenases, short chain protein 2 0.0004 0.0002 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.037 0.037
Loa Loa (eye worm) dehydrogenase 0.0004 0.0002 0.0004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0264 0.0264
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.037 0.0827
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0004 0.0002 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0004 0.0002 0.0043
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.0002 0.0002
Leishmania major short chain dehydrogenase, putative 0.0004 0.0002 0.0004
Entamoeba histolytica short chain dehydrogenase family protein 0.0004 0.0002 0.0004
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0082
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0004 0.0002 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0.0002 0.0026
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.0002 0.0002
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0002 0.0004
Schistosoma mansoni cpg binding protein 0.0029 0.0615 0.0615
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0004 0.0002 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0004 0.0002 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.037 1
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0002 0.0002
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0004 0.0002 0.0043
Entamoeba histolytica hypothetical protein 0.0004 0.0002 0.0004
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0002 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Toxoplasma gondii exonuclease III APE 0.0019 0.037 0.0827
Giardia lamblia Short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.037 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.2434 0.2434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.141 0.141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0004 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Leishmania major pteridine reductase 1 0.0004 0.0002 0.0004
Leishmania major hypothetical protein, conserved 0.0004 0.0002 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.0002 0.0002
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0004 0.0002 0.0043
Onchocerca volvulus Sepiapterin reductase homolog 0.0004 0.0002 0.0026
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0004 0.0002 0.0043
Echinococcus multilocularis cpg binding protein 0.003 0.0655 0.0655
Leishmania major dehydrogenase-like protein 0.0004 0.0002 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0655 0.0655
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0004 0.0002 0.5
Brugia malayi Bm-MIF-1, identical 0.0186 0.4481 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0004 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0082 0.0082
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0004 0.0002 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0002 0.0002
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.4481 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0004 0.0002 0.0004
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.0002 0.0002
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0004 0.0002 0.0004
Leishmania major short chain dehydrogenase/reductase, putative 0.0004 0.0002 0.0004
Leishmania major short chain dehydrogenase, putative 0.0004 0.0002 0.0004
Giardia lamblia Reductase, putative 0.0004 0.0002 0.0004
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Mycobacterium tuberculosis Probable dehydrogenase 0.0004 0.0002 0.0043
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.0002 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.1592 0.1592
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0655 0.0655
Echinococcus granulosus cpg binding protein 0.003 0.0655 0.0655
Echinococcus multilocularis retinol dehydrogenase 13 0.0004 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0004 0.0002 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0004 0.0002 0.0043
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0004 0.0002 0.0002
Echinococcus multilocularis conserved hypothetical protein 0.0004 0.0002 0.0002
Plasmodium falciparum steroid dehydrogenase, putative 0.0004 0.0002 0.0004
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0.0002 0.0004
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0004 0.0002 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0002 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Schistosoma mansoni carbonyl reductase 0.0004 0.0002 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.037 0.0827
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0068 0.1592 0.3552
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.037 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0004 0.0002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Brugia malayi Retinol dehydrogenase 12 0.0004 0.0002 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.037 0.0827
Schistosoma mansoni steroid dehydrogenase 0.0004 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1249 0.2787
Trichomonas vaginalis helicase, putative 0.0007 0.0067 0.0149
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0004 0.0002 0.0002
Toxoplasma gondii oxidoreductase, putative 0.0004 0.0002 0.0004
Entamoeba histolytica short chain dehydrogenase family protein 0.0004 0.0002 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0149
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Echinococcus granulosus WW domain containing oxidoreductase 0.0004 0.0002 0.0002
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0004 0.0002 0.0043
Echinococcus granulosus oxidoreductase 0.0004 0.0002 0.0002
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Schistosoma mansoni carbonyl reductase 0.0004 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.037 0.037
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0004 0.0002 0.0043
Schistosoma mansoni ap endonuclease 0.0019 0.037 0.037
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0149
Onchocerca volvulus 0.0004 0.0002 0.0026
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0186 0.4481 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0004 0.0002 0.0043
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Echinococcus multilocularis oxidoreductase 0.0004 0.0002 0.0002
Mycobacterium leprae Probable oxidoreductase 0.0004 0.0002 0.5
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0079 0.1858 0.4146
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.037 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0004 0.0002 0.0002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0004 0.0002 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0186 0.4481 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.037 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.0002 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Giardia lamblia Macrophage migration inhibitory factor 0.0186 0.4481 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0615 0.1372
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Leishmania major short chain dehydrogenase-like protein 0.0004 0.0002 0.0004
Loa Loa (eye worm) dehydrogenase 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0004 0.0002 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0264 0.0589
Leishmania major short chain dehydrogenase/reductase, putative 0.0004 0.0002 0.0004
Onchocerca volvulus 0.0004 0.0002 0.0026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.037 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.0002 0.0043
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.0002 0.0004
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0.0002 0.0026
Leishmania major hypothetical protein, conserved 0.0004 0.0002 0.0004
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0004 0.0002 0.0004
Schistosoma mansoni ap endonuclease 0.0019 0.037 0.037
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.1592 0.3552
Onchocerca volvulus 0.0004 0.0002 0.0026
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0123 0.0274
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.037 0.0827
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0615 0.1372
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.0002 0.0004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.2434 0.2434
Mycobacterium tuberculosis Possible oxidoreductase 0.0004 0.0002 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.0002 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Echinococcus granulosus carbonyl reductase 1 0.0004 0.0002 0.0002
Schistosoma mansoni short chain dehydrogenase 0.0004 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.041 1 1
Leishmania major hypothetical protein, conserved 0.0004 0.0002 0.0004
Mycobacterium tuberculosis Possible oxidoreductase 0.0004 0.0002 0.0043
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0004 0.0002 0.0043
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0004 0.0002 0.0043
Onchocerca volvulus 0.0004 0.0002 0.0026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.2434 0.2434
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.0002 0.0004
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0004 0.0002 0.0004
Loa Loa (eye worm) oxidoreductase 0.0004 0.0002 0.0004
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0004 0.0002 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0002 0.0043
Schistosoma mansoni carbonyl reductase 0.0004 0.0002 0.0002
Leishmania major oxidoreductase-like protein 0.0004 0.0002 0.0004
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.0002 0.0043
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0004 0.0002 0.0002
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0004 0.0002 0.0043
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0149
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0004 0.0002 0.0002
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0079 0.1858 0.4146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0082 0.0082

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) = 0.25 ug ml-1 Antifungal activity against Candida albicans Y0109 after 24 hrs by serial dilution method ChEMBL. 21983332
MIC80 (functional) = 4 ug ml-1 Antifungal activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method ChEMBL. 21983332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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