Detailed information for compound 1565907

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 921.045 | Formula: C43H68N8O14
  • H donors: 12 H acceptors: 14 LogP: -2.15 Rotable bonds: 36
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C[C@@H]([C@H](C[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CCC(=O)O)C)C(C)C)O)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)N)CC(=O)N)C
  • InChi: 1S/C43H68N8O14/c1-21(2)17-29(48-41(62)30(20-33(45)53)49-42(63)36(23(5)6)51-39(60)27(44)13-15-34(54)55)32(52)19-26(22(3)4)38(59)46-24(7)37(58)47-28(14-16-35(56)57)40(61)50-31(43(64)65)18-25-11-9-8-10-12-25/h8-12,21-24,26-32,36,52H,13-20,44H2,1-7H3,(H2,45,53)(H,46,59)(H,47,58)(H,48,62)(H,49,63)(H,50,61)(H,51,60)(H,54,55)(H,56,57)(H,64,65)/t24-,26-,27-,28-,29-,30-,31-,32-,36-/m0/s1
  • InChiKey: AQVQJKSMBFXSEE-PFCVTPPASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens beta-site APP-cleaving enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni memapsin-2 (A01 family) Get druggable targets OG5_135830 All targets in OG5_135830
Schistosoma japonicum ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative Get druggable targets OG5_135830 All targets in OG5_135830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin VII beta-site APP-cleaving enzyme 1 401 aa 352 aa 21.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0163 0.0364 0.0361
Onchocerca volvulus Matrix metalloproteinase homolog 0.0297 0.0677 0.4811
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0143 0.0177
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0015 0.0022
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0087 0.0185 0.0458
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Onchocerca volvulus 0.0031 0.0053 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0239 0.2019
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0087 0.0185 0.0544
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0038 0.0052
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0087 0.0185 0.0262
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0006 0.0008
Brugia malayi Muscle positioning protein 4 0.0009 0.0003 0.0004
Echinococcus granulosus snurportin 1 0.0298 0.0681 0.0971
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0015 0.0022
Leishmania major hypothetical protein, conserved 0.0087 0.0185 0.0265
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0163 0.0364 0.0521
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0046 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Brugia malayi ancient conserved domain protein 4 0.0087 0.0185 0.0265
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.003 0.0016
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1793 0.4185 0.4183
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Trichomonas vaginalis ABC transporter, putative 0.001 0.0006 0.0051
Plasmodium falciparum plasmepsin V 0.0178 0.04 0.0942
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus H:Cl exchange transporter 7 0.0087 0.0185 0.0262
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0035 0.0294
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0015 0.0013
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1461 0.3407 0.4876
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0069 0.0143 0.0205
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0087 0.0185 0.0238
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0009 0.0003 0.0004
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0022 0.0046
Schistosoma mansoni chloride channel protein 0.0087 0.0185 0.0265
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0087 0.0185 0.0544
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0267 0.0607 0.0869
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0038 0.0055
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0015 0.0019
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0015 0.0022
Brugia malayi TATA binding protein associated factor 0.0024 0.0038 0.0055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.003 0.0088
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0087 0.0185 0.0544
Schistosoma mansoni slit 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2988 0.6985 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0072 0.0212
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.003 0.0087
Schistosoma mansoni opsin-like receptor 0.0014 0.0015 0.0022
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0015 0.0019
Trichomonas vaginalis abcb9, putative 0.001 0.0006 0.0051
Echinococcus granulosus somatostatin receptor 0.0014 0.0015 0.0019
Schistosoma mansoni ribosomal RNA methyltransferase 0.0016 0.0019 0.0028
Onchocerca volvulus 0.0178 0.04 0.2831
Onchocerca volvulus 0.0134 0.0295 0.2088
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0163 0.0364 0.1068
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0211 0.0303
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0087 0.0185 0.0458
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0015 0.0013
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Onchocerca volvulus 0.0014 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis geminin 0.018 0.0404 0.0575
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0767 0.178 0.5225
Loa Loa (eye worm) hypothetical protein 0.0067 0.0139 0.0136
Brugia malayi loechrig isoform VII 0.0087 0.0185 0.0265
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0267 0.0607 0.0869
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0015 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Brugia malayi Blistered cuticle protein 3 0.0069 0.0143 0.0204
Leishmania major p-glycoprotein 0.001 0.0006 0.0009
Schistosoma mansoni amine GPCR 0.0014 0.0015 0.0022
Loa Loa (eye worm) chloride channel protein 7 0.0087 0.0185 0.0183
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2988 0.6985 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.0522 0.0519
Onchocerca volvulus 0.0017 0.0022 0.0138
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0143 0.014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0054 0.0052
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0015 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0061 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0015 0.0019
Plasmodium vivax aspartyl protease, putative 0.0178 0.04 0.1231
Plasmodium falciparum carbonic anhydrase 0.1793 0.4185 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.01 0.014
Brugia malayi GMP reductase 0.0607 0.1405 0.2012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0143 0.0204
Mycobacterium leprae conserved hypothetical protein 0.0087 0.0185 0.0541
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2988 0.6985 0.6984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0015 0.0019
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0694 0.1608 0.4721
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0087 0.0185 0.0437
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.0087 0.0185 0.0183
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0038 0.0101
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0015 0.0019
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0046 0.0133
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1461 0.3407 1
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0003 0.0005
Onchocerca volvulus 0.001 0.0006 0.0024
Echinococcus multilocularis serotonin receptor 0.0014 0.0015 0.0019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0015 0.0022
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0087 0.0185 0.0234
Loa Loa (eye worm) hypothetical protein 0.0045 0.0086 0.0084
Brugia malayi Muscleblind-like protein 0.0624 0.1443 0.2066
Toxoplasma gondii aspartyl protease ASP3 0.0339 0.0776 0.1849
Trypanosoma cruzi GMP reductase 0.1461 0.3407 0.4861
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0015 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0015 0.0019
Plasmodium vivax aspartyl protease, putative 0.0339 0.0776 0.2407
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0694 0.1608 0.472
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0015 0.0013
Brugia malayi Matrixin family protein 0.0134 0.0295 0.0423
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0087 0.0185 0.0544
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1461 0.3407 0.4877
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0009
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0087 0.0185 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0038 0.0112
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.1606 0.2297
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0143 0.1207
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0003 0.0004
Schistosoma mansoni chloride channel protein 0.0087 0.0185 0.0265
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0025 0.0053
Schistosoma mansoni adenoreceptor 0.0014 0.0015 0.0022
Schistosoma mansoni chloride channel protein 0.0087 0.0185 0.0265
Echinococcus multilocularis protein dispatched 1 0.011 0.0239 0.0339
Toxoplasma gondii exonuclease III APE 0.0021 0.003 0.0067
Onchocerca volvulus 0.0069 0.0143 0.0999
Leishmania major hypothetical protein, conserved 0.0017 0.0022 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0262 0.0596 0.5029
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0091 0.0628
Schistosoma mansoni neuropeptide receptor 0.0014 0.0015 0.0022
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0042 0.006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0015 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0053 0.0051
Schistosoma mansoni hypothetical protein 0.0298 0.0681 0.0974
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0055
Echinococcus multilocularis carbonic anhydrase 0.1793 0.4185 0.599
Echinococcus multilocularis carbonic anhydrase 0.1793 0.4185 0.599
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.004 0.0118
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0 0.0001
Brugia malayi larval opioid receptor 0.0014 0.0015 0.0022
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0236 0.0534 0.0761
Brugia malayi Pre-SET motif family protein 0.023 0.0522 0.0747
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0239 0.0339
Onchocerca volvulus 0.0014 0.0015 0.0091
Onchocerca volvulus 0.0034 0.0061 0.0413
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0009 0.0003 0.0005
Brugia malayi CLC chloride channel protein 0.0087 0.0185 0.0265
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0087 0.0185 0.0262
Plasmodium falciparum large subunit rRNA methyltransferase, putative 0.0016 0.0019 0.0032
Onchocerca volvulus 0.0014 0.0015 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0239 0.0342
Echinococcus granulosus Protein patched homolog 1 0.011 0.0239 0.0339
Brugia malayi GCC2 and GCC3 family protein 0.0009 0.0003 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0513 0.1185 1
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0006 0.0003
Schistosoma mansoni protein kinase subunit gamma 0.0087 0.0185 0.0265
Schistosoma mansoni hypothetical protein 0.018 0.0404 0.0579
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) acyl carrier protein 0.0012 0.001 0.0007
Entamoeba histolytica aminopeptidase, putative 0.0069 0.0143 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Leishmania major chloride channel protein, putative 0.0087 0.0185 0.0265
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0036
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0086 0.0124
Onchocerca volvulus 0.0014 0.0015 0.0091
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0015 0.0019
Trichomonas vaginalis taga, putative 0.001 0.0006 0.0051
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0165 0.0368 0.0366
Onchocerca volvulus 0.0014 0.0015 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0054 0.0074
Echinococcus multilocularis serotonin receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) chloride channel 3 0.0087 0.0185 0.0183
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Echinococcus granulosus carbonic anhydrase II 0.2988 0.6985 1
Brugia malayi G protein-coupled receptor 0.0014 0.0015 0.0022
Toxoplasma gondii CBS domain-containing protein 0.0087 0.0185 0.0437
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0038 0.0078
Leishmania major carbonic anhydrase-like protein 0.2988 0.6985 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0006 0.0051
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Echinococcus granulosus sterol regulatory element binding protein 0.011 0.0239 0.0339
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0006 0.0005
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.011 0.0239 0.0237
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0015 0.0022
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0015 0.0022
Onchocerca volvulus 0.0069 0.0143 0.0999
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0024 0.0038 0.0036
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1793 0.4185 0.5991
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0236 0.0534 0.0761
Onchocerca volvulus 0.0024 0.0038 0.0254
Onchocerca volvulus 0.0014 0.0015 0.0091
Brugia malayi neuropeptide F receptor 0.0014 0.0015 0.0022
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0015 0.0022
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0001 0.0001
Brugia malayi Dopamine receptor 0.0014 0.0015 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0015 0.0019
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Toxoplasma gondii hypothetical protein 0.1793 0.4185 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0017
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0178 0.04 0.0397
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0015 0.0019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0042 0.0123
Brugia malayi Animal haem peroxidase family protein 0.0072 0.0149 0.0214
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0046 0.0133
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0015 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0211 0.0303
Echinococcus granulosus aminopeptidase N 0.0234 0.0529 0.0755
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0046 0.0135
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0022
Brugia malayi putative neuropeptide receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) peptidase family M1 containing protein 0.0189 0.0425 0.0422
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0012 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.003 0.1782
Brugia malayi Eukaryotic aspartyl protease family protein 0.0178 0.04 0.0572
Onchocerca volvulus 0.0069 0.0143 0.1001
Brugia malayi aspartic protease BmAsp-1, identical 0.0178 0.04 0.0572
Onchocerca volvulus 0.0178 0.04 0.2831
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0286 0.041
Mycobacterium ulcerans hypothetical protein 0.0087 0.0185 0.0543
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0003 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0054 0.0074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.003 0.0044
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0134 0.0295 0.0293
Schistosoma mansoni biogenic amine receptor 0.0014 0.0015 0.0022
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0038 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0061 0.0083
Trypanosoma cruzi Aminopeptidase M1, putative 0.0069 0.0143 0.0174
Brugia malayi hypothetical protein 0.0069 0.0143 0.0205
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.018 0.0404 0.0579
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.01 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Echinococcus granulosus microtubule associated protein 2 0.0693 0.1606 0.2297
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0015 0.0019
Schistosoma mansoni opsin-like receptor 0.0014 0.0015 0.0022
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase 0.0016 0.0019 0.0024
Onchocerca volvulus 0.0069 0.0143 0.0999
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0143 0.0204
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0012 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0061 0.0087
Schistosoma mansoni septate junction protein 0.0009 0.0003 0.0004
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative 0.0016 0.0019 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.003 0.0012
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0267 0.0607 0.084
Trypanosoma brucei GMP reductase 0.1461 0.3407 0.4863
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0015 0.0019
Loa Loa (eye worm) ribosomal RNA methyltransferase 0.0016 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0087 0.0185 0.0183
Echinococcus multilocularis serine:threonine protein kinase 0.0236 0.0534 0.0761
Onchocerca volvulus 0.0087 0.0185 0.1302
Brugia malayi CXXC zinc finger family protein 0.0031 0.0053 0.0076
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0006 0.0008
Plasmodium vivax aspartyl proteinase, putative 0.0513 0.1185 0.3687
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2988 0.6985 1
Schistosoma mansoni patched 1 0.011 0.0239 0.0342
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0015 0.0013
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0009 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Schistosoma mansoni peroxidasin 0.0069 0.0143 0.0204
Echinococcus multilocularis carbonic anhydrase 0.1793 0.4185 0.599
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0143 0.1207
Echinococcus granulosus cpg binding protein 0.0032 0.0057 0.0079
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0031 0.0092
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0006 0.0005
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0022 0.005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Schistosoma mansoni multidrug resistance protein 0.001 0.0006 0.0009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0076
Brugia malayi hypothetical protein 0.0178 0.04 0.0572
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0015 0.0013
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0015 0.0022
Schistosoma mansoni cathepsin D (A01 family) 0.1556 0.3628 0.5194
Echinococcus granulosus GPCR family 2 0.0031 0.0054 0.0074
Schistosoma mansoni amine GPCR 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0038 0.0027
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0038 0.0055
Brugia malayi Dopamine receptor protein 1 0.0014 0.0015 0.0022
Echinococcus granulosus allatostatin A receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0006 0.0003
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0015 0.0019
Mycobacterium ulcerans hypothetical protein 0.0087 0.0185 0.0543
Echinococcus granulosus H:Cl exchange transporter 4 0.0087 0.0185 0.0262
Trypanosoma cruzi chloride channel protein, putative 0.0087 0.0185 0.0234
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0015 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0015 0.0019
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0009 0.0003 0.000000023055
Loa Loa (eye worm) blistered cuticle protein 3 0.0069 0.0143 0.014
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0046 0.0134
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0087 0.0185 0.0265
Echinococcus granulosus g protein coupled receptor 0.0014 0.0015 0.0019
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0275 0.2322
Brugia malayi sulfakinin receptor protein 0.0014 0.0015 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0015 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0061 0.0087
Echinococcus granulosus sex peptide receptor 0.0014 0.0015 0.0019
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0022 0.0028
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0022
Brugia malayi RE15519p 0.0014 0.0015 0.0022
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0006 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0015 0.0019
Giardia lamblia High cysteine protein 0.0009 0.0003 0.0095
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0006 0.0005
Onchocerca volvulus Matrilysin homolog 0.0297 0.0677 0.4811
Schistosoma mansoni laminin gamma-3 chain 0.0009 0.0003 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0042 0.0122
Echinococcus granulosus H:Cl exchange transporter 3 0.0087 0.0185 0.0262
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0015 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0015 0.0019
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1461 0.3407 0.4877
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0087 0.0185 0.0544
Loa Loa (eye worm) hypothetical protein 0.0043 0.0083 0.0081
Trichomonas vaginalis ABC transporter, putative 0.001 0.0006 0.0051
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0087 0.0185 0.0544
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0143 0.0205
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0487 0.1122 0.1603
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0017 0.0022 0.0063
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0046 0.0135
Brugia malayi G-protein coupled receptor 0.0014 0.0015 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0143 0.0205
Plasmodium falciparum importin beta, putative 0.0028 0.0047 0.0099
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0087 0.0185 0.6731
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0015 0.0022
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0038 0.0086
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0078
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0041 0.0039
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0006 0.0005
Trichomonas vaginalis abcb9, putative 0.001 0.0006 0.0051
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0015 0.0022
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0038 0.0325
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0038 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.0016 0.0019 0.004
Brugia malayi RNA, U transporter 1 0.0079 0.0168 0.024
Brugia malayi Melatonin receptor type 1A 0.0014 0.0015 0.0022
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Brugia malayi rRNA methyltransferase 0.0016 0.0019 0.0028
Onchocerca volvulus 0.0045 0.0087 0.0601
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.0016 0.0019 0.0032
Onchocerca volvulus Peroxidase homolog 0.0069 0.0143 0.0999
Toxoplasma gondii CBS family protein 0.0087 0.0185 0.0437
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0087 0.0185 0.0265
Schistosoma mansoni histamine h1 receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) aminopeptidase N 0.0069 0.0143 0.014
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.0016 0.0019 0.0163
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.003 0.004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0042 0.0124
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.0016 0.0019 0.0972
Leishmania major CBS domain protein, conserved 0.0087 0.0185 0.0265
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0006 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Brugia malayi hypothetical protein 0.0069 0.0143 0.0204
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0143 0.0204
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0015 0.0019
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0006 0.0005
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0025 0.0074
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0015 0.0019
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0164 0.0366 0.0524
Chlamydia trachomatis CBS domain-containing protein 0.0087 0.0185 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1793 0.4185 0.5991
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.003 0.0088
Onchocerca volvulus Peroxidasin homolog 0.0072 0.0149 0.1047
Onchocerca volvulus 0.0014 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0286 0.0839
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0286 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0015 0.0019
Giardia lamblia FtsJ cell division protein, putative 0.0016 0.0019 0.0703
Brugia malayi hypothetical protein 0.0178 0.04 0.0572
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0003 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0015 0.0019
Brugia malayi Kringle domain containing protein 0.0017 0.0022 0.0031
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0015 0.0022
Schistosoma mansoni neuropeptide receptor 0.0014 0.0015 0.0022
Echinococcus multilocularis cpg binding protein 0.0032 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Schistosoma mansoni biogenic amine receptor 0.0014 0.0015 0.0022
Echinococcus multilocularis carbonic anhydrase II 0.2988 0.6985 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0054 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Schistosoma mansoni cell polarity protein 0.0009 0.0003 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Onchocerca volvulus 0.0014 0.0015 0.0091
Echinococcus multilocularis snurportin 1 0.0298 0.0681 0.0971
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.01 0.014
Onchocerca volvulus Putative ribosomal RNA methyltransferase 0.0016 0.0019 0.0119
Brugia malayi ancient conserved domain protein 2 0.0087 0.0185 0.0265
Schistosoma mansoni carbonic anhydrase-related 0.1793 0.4185 0.5991
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0513 0.1185 0.1697
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1461 0.3407 0.4861
Onchocerca volvulus 0.0014 0.0015 0.0091
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0143 0.0205
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0047 0.0064
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0015 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0015 0.0019
Brugia malayi Serotonin receptor 0.0014 0.0015 0.0022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.003 0.0076
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0087 0.0185 0.0262
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0286 0.0406
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0211 0.0209
Brugia malayi Serotonin receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0045
Brugia malayi hypothetical protein 0.0024 0.0038 0.0055
Trichomonas vaginalis ABC transporter, putative 0.001 0.0006 0.0051
Mycobacterium tuberculosis Conserved protein 0.0087 0.0185 0.0544
Loa Loa (eye worm) matrixin family protein 0.0297 0.0677 0.0675
Onchocerca volvulus 0.0014 0.0015 0.0091
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0015 0.0019
Onchocerca volvulus 0.0024 0.0038 0.0256
Plasmodium vivax aspartyl proteinase, putative 0.0178 0.04 0.1231
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0143 0.014
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0015 0.0022
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0016 0.0047
Brugia malayi AKH receptor 0.0014 0.0015 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0015 0.0019
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0024 0.0038 0.0052
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0015 0.0019
Brugia malayi Matrixin family protein 0.0134 0.0295 0.0423
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0015 0.0019
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0038 0.0086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.003 0.0669
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1461 0.3407 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0024 0.0038 0.0052
Plasmodium falciparum plasmepsin VI 0.0513 0.1185 0.2821
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0087 0.0185 0.0262
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0143 0.0177
Onchocerca volvulus 0.0014 0.0015 0.0091
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0267 0.0607 0.084
Loa Loa (eye worm) hypothetical protein 0.0178 0.04 0.0397
Onchocerca volvulus 0.0014 0.0015 0.0091
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0087 0.0185 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0015 0.0022
Giardia lamblia Hypothetical protein 0.0087 0.0185 0.6731
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.0624 0.1443 0.1441
Loa Loa (eye worm) hypothetical protein 0.0098 0.0211 0.0209
Echinococcus granulosus muscleblind protein 0.0624 0.1443 0.2063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0209 0.0473 0.047
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0038 0.0055
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0012 0.001 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0047 0.0107
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0015 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.01 0.0143
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0015 0.0022
Loa Loa (eye worm) IMP dehydrogenase 1 0.1461 0.3407 0.3405
Echinococcus granulosus orexin receptor type 2 0.0014 0.0015 0.0019
Leishmania major importin beta-1 subunit, putative 0.0023 0.0035 0.005
Echinococcus multilocularis protein patched 0.011 0.0239 0.0339
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0513 0.1185 0.1694
Brugia malayi ORL1-like opioid receptor 0.0014 0.0015 0.0022
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2988 0.6985 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0513 0.1185 0.1694
Brugia malayi Pre-SET motif family protein 0.0034 0.0061 0.0087
Loa Loa (eye worm) carbonic anhydrase 3 0.2988 0.6985 0.6984
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0035 0.0294
Mycobacterium ulcerans hypothetical protein 0.0087 0.0185 0.0543
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0003 0.0001
Schistosoma mansoni cathepsin D (A01 family) 0.1556 0.3628 0.5194
Loa Loa (eye worm) matrixin family protein 0.0324 0.074 0.0738
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0038 0.0086
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.025 0.0355
Plasmodium falciparum plasmepsin IV 0.0513 0.1185 0.2821
Echinococcus granulosus tm gpcr rhodopsin 0.1056 0.2457 0.3515
Brugia malayi CBS domain containing protein 0.0087 0.0185 0.0265
Plasmodium falciparum plasmepsin VIII, putative 0.0178 0.04 0.0942
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1461 0.3407 0.4876
Echinococcus multilocularis GPCR, family 2 0.0031 0.0054 0.0074
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0513 0.1185 0.1183
Schistosoma mansoni myosin xvIII 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0178 0.04 0.0397
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0038 0.0101
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0015 0.0019
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0006 0.0009
Trichomonas vaginalis ABC transporter, putative 0.001 0.0006 0.0051
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.025 0.0355
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Echinococcus multilocularis aminopeptidase N 0.0234 0.0529 0.0755
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0767 0.178 0.5224
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0015 0.0019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1793 0.4185 0.5991
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0036
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0007 0.0009
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0087 0.0185 0.0262
Onchocerca volvulus 0.019 0.0426 0.3022
Plasmodium falciparum plasmepsin IX 0.0339 0.0776 0.1842
Mycobacterium tuberculosis Conserved protein 0.0087 0.0185 0.0544
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.003 0.1106
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Loa Loa (eye worm) loechrig isoform VII 0.0087 0.0185 0.0183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.003 0.0012
Trypanosoma brucei carbonic anhydrase-like protein 0.2988 0.6985 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0024 0.0038 0.0055
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1375 0.3203 0.7651
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0012 0.001 0.0015
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0012 0.0023
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.1793 0.4185 0.4183
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0035 0.0294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Leishmania major chloride channel protein, putative 0.0087 0.0185 0.0265
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0015 0.0019
Chlamydia trachomatis Mg++ transporter 0.0087 0.0185 1
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0015 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.003 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0015 0.0013
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.2107
Mycobacterium leprae PROBABLE HYDROLASE 0.0163 0.0364 0.1066
Loa Loa (eye worm) aspartyl protease 6 0.0178 0.04 0.0397
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1056 0.2457 0.3515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0000000032343
Schistosoma mansoni amine GPCR 0.0014 0.0015 0.0022
Brugia malayi Delta serrate ligand family protein 0.0009 0.0003 0.0004
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0487 0.1122 0.1603
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0143 0.0204
Brugia malayi Protein kinase domain containing protein 0.0017 0.0022 0.0031
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.011 0.0239 0.0237
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0015 0.0019
Brugia malayi Matrixin family protein 0.0324 0.074 0.106
Echinococcus granulosus importin subunit beta 1 0.0028 0.0047 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.004
Brugia malayi multidrug resistance protein 3 0.001 0.0006 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0042 0.0123
Schistosoma mansoni smdr2 0.001 0.0006 0.0009
Schistosoma mansoni cell division protein ftsj 0.0016 0.0019 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Schistosoma mansoni memapsin-2 (A01 family) 0.1416 0.3301 0.4726
Loa Loa (eye worm) hypothetical protein 0.0087 0.0185 0.0183
Onchocerca volvulus Matrilysin homolog 0.0134 0.0295 0.2088
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0082
Schistosoma mansoni opsin-like receptor 0.0014 0.0015 0.0022
Schistosoma mansoni carbonic anhydrase-related 0.1793 0.4185 0.5991
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0009 0.0003 0.0004
Onchocerca volvulus Neurogenic locus notch homolog 0.0009 0.0003 0.000000023055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0114 0.025 0.0358
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0087 0.0185 0.6731
Schistosoma mansoni neuropeptide receptor 0.0014 0.0015 0.0022
Echinococcus granulosus geminin 0.018 0.0404 0.0575
Plasmodium falciparum plasmepsin III 0.0178 0.04 0.0942
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0032 0.0092
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0015 0.0019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0017 0.0022 0.0062
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0022
Echinococcus granulosus neuropeptide receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0624 0.1443 0.1441
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0607 0.1405 0.2012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0015 0.0019
Brugia malayi Angiotensin-converting enzyme family protein 0.061 0.141 0.2019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0003
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0015 0.0019
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0114 0.025 0.0358
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0087 0.0185 0.0262
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0125 0.0275 1
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0513 0.1185 0.1183
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0015 0.0022
Brugia malayi GnHR receptor homolog 0.0014 0.0015 0.0022
Leishmania major guanosine monophosphate reductase 0.1461 0.3407 0.4877
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0003 0.0001
Mycobacterium ulcerans thioesterase 0.0021 0.0032 0.0093
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1461 0.3407 1
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0087 0.0185 0.0234
Schistosoma mansoni ap endonuclease 0.0021 0.003 0.0044
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0003 0.0005
Onchocerca volvulus 0.0014 0.0015 0.0091
Brugia malayi Matrixin family protein 0.0134 0.0295 0.0423
Echinococcus granulosus carbonic anhydrase 0.1793 0.4185 0.599
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Treponema pallidum Mg2+ transport protein (mgtE) 0.0087 0.0185 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0046 0.0134
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0003 0.0001
Echinococcus multilocularis sterol regulatory element binding protein 0.011 0.0239 0.0339
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0015 0.0022
Onchocerca volvulus Dual oxidase homolog 0.0069 0.0143 0.0999
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0082
Echinococcus granulosus rrna methyltransferase 3 0.0016 0.0019 0.0024
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0267 0.0607 0.0869
Echinococcus granulosus fmrfamide receptor 0.0014 0.0015 0.0019
Mycobacterium tuberculosis Conserved protein 0.0087 0.0185 0.0544
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0607 0.1405 0.2012
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0087 0.0185 0.0238
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0087 0.0185 0.0238
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Plasmodium vivax aspartyl protease, putative 0.0339 0.0776 0.2407
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0006 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.1606 0.23
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0042 0.0123
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0038 0.0052
Toxoplasma gondii IMP dehydrogenas 0.1461 0.3407 0.814
Echinococcus multilocularis somatostatin receptor 0.0014 0.0015 0.0019
Brugia malayi ribosomal RNA methyltransferase 0.0016 0.0019 0.0028
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.003 0.0058
Treponema pallidum hemolysin (tlyC) 0.0087 0.0185 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0036
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0006 0.0005
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0134 0.0295 0.0423
Trypanosoma cruzi GMP reductase 0.1461 0.3407 0.4861
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0267 0.0607 0.0866
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0286 0.0678
Loa Loa (eye worm) hypothetical protein 0.0045 0.0086 0.0084
Brugia malayi Dopamine receptor protein 2 0.0014 0.0015 0.0022
Mycobacterium ulcerans polyketide synthase 0.0027 0.0046 0.0134
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Plasmodium falciparum plasmepsin VII 0.0178 0.04 0.0942
Brugia malayi neuropeptide F receptor 0.0014 0.0015 0.0022
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Mycobacterium ulcerans aminopeptidase N PepN 0.0069 0.0143 0.0419
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0038 0.0024
Trypanosoma cruzi aminopeptidase, putative 0.0069 0.0143 0.0174
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0015 0.0019
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0038 0.0036
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0006 0.0051
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0015 0.0019
Schistosoma mansoni importin beta-1 0.0028 0.0047 0.0068
Echinococcus granulosus neuropeptide receptor 0.0014 0.0015 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0015 0.0022
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0038 0.0024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.012 0.0281
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0178 0.04 0.0949
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0087 0.0185 0.0262
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0087 0.0185 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0061 0.0087
Plasmodium vivax FtsJ-like methyltransferase, putative 0.0016 0.0019 0.0042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Brugia malayi Peptidase family M1 containing protein 0.0234 0.0529 0.0758
Plasmodium vivax plasmepsin V, putative 0.0178 0.04 0.1231
Onchocerca volvulus 0.0014 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.0134 0.0295 0.0293
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0015 0.0022
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0015 0.0019
Mycobacterium ulcerans polyketide synthase 0.0026 0.0042 0.0123
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.01 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0012 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Toxoplasma gondii aspartyl protease ASP1 0.0513 0.1185 0.2827
Brugia malayi hypothetical protein 0.0014 0.0015 0.0022
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.061 0.141 0.1408
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein 0.0016 0.0019 0.004
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.01 0.0143
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1375 0.3203 0.9403
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0054 0.0078
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.003 0.0044
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0032 0.0093
Loa Loa (eye worm) GMP reductase 0.0607 0.1405 0.1403
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.025 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Loa Loa (eye worm) animal heme peroxidase 0.0072 0.0149 0.0147
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0061 0.0083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0042 0.0122
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0015 0.0013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0286 0.084
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Brugia malayi Pepsin A precursor 0.0178 0.04 0.0572
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0015 0.0019
Mycobacterium ulcerans hydrolase 0.0163 0.0364 0.1067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.01 0.014
Mycobacterium ulcerans polyketide synthase Pks9 0.0017 0.0022 0.0063
Brugia malayi notch-like transmembrane receptor 0.0009 0.0003 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0056 0.0077
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0038 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0054 0.0078
Brugia malayi Cadherin domain containing protein 0.0009 0.0003 0.0004
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0009 0.0003 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0015 0.0019
Echinococcus granulosus g protein coupled receptor 0.0014 0.0015 0.0019
Onchocerca volvulus Putative GMP reductase 0.0607 0.1405 1
Loa Loa (eye worm) hypothetical protein 0.0267 0.0607 0.0605
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0015 0.0019
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0143 0.0201
Schistosoma mansoni carbonic anhydrase-related 0.1793 0.4185 0.5991
Schistosoma mansoni amine GPCR 0.0014 0.0015 0.0022
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0267 0.0607 0.1781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Brugia malayi Voltage gated chloride channel family protein 0.0087 0.0185 0.0265
Brugia malayi Matrixin family protein 0.0134 0.0295 0.0423
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0038 0.0078
Brugia malayi EGF-like domain containing protein 0.0009 0.0003 0.0004
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0015 0.0013
Brugia malayi G-protein coupled receptor 0.0014 0.0015 0.0022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Schistosoma mansoni hypothetical protein 0.0067 0.0139 0.0199
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0015 0.0091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0015 0.0019
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0006 0.0005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0061 0.0083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.025 0.0355
Schistosoma mansoni neuropeptide receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0513 0.1185 0.2827
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1461 0.3407 1
Echinococcus multilocularis rrna methyltransferase 3 0.0016 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.1793 0.4185 0.4183
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0015 0.0022
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0072 0.0212
Schistosoma mansoni peroxidasin 0.0069 0.0143 0.0204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0015 0.0091
Trypanosoma cruzi chloride channel protein, putative 0.0087 0.0185 0.0234
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0069 0.0143 0.0201
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0086 0.0092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.01 0.0098
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0087 0.0185 0.0541
Onchocerca volvulus Chorion peroxidase homolog 0.0069 0.0143 0.0999
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0143 0.0177
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0003 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0015 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0035 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2988 0.6985 1
Plasmodium falciparum plasmepsin X 0.0339 0.0776 0.1842
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0086 0.012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.003 0.0089
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Trypanosoma cruzi chloride channel protein, putative 0.0087 0.0185 0.0234
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.003 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0149 0.0147
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0012 0.001 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0136 0.0195
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0013
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0003 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0286 0.0406
Schistosoma mansoni ap endonuclease 0.0021 0.003 0.0044
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0006 0.0051
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0038 0.0112
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0015 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1461 0.3407 0.4861
Schistosoma mansoni hypothetical protein 0.019 0.0426 0.0611
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0143 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0139 0.0199
Mycobacterium ulcerans cystathionine beta-synthase 0.0087 0.0185 0.0543
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0681 0.0678
Echinococcus multilocularis muscleblind protein 1 0.0624 0.1443 0.2063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0061 0.0087
Plasmodium vivax SET domain protein, putative 0.0034 0.0061 0.0171
Onchocerca volvulus 0.0014 0.0015 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0286 0.0839
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0286 0.041
Brugia malayi chloride channel protein 7 0.0087 0.0185 0.0265
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0042 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0087 0.0185 0.6731
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.003 0.0088
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0003 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0178 0.04 0.0572
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0015 0.0019
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0001 0.0002
Echinococcus granulosus serotonin receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Onchocerca volvulus 0.0234 0.0529 0.3755
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0015 0.0019
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0275 0.2322
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0006 0.0018
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0015 0.0019
Brugia malayi ABC transporter family protein 0.001 0.0006 0.0009
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0096 0.0138
Echinococcus granulosus carbonic anhydrase 0.1793 0.4185 0.599
Echinococcus granulosus serine:threonine protein kinase 0.0236 0.0534 0.0761
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0006 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0042 0.0123
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0275 0.2322
Schistosoma mansoni multidrug resistance protein 0.001 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0185 0.0183
Schistosoma mansoni multidrug resistance protein 0.001 0.0006 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0015 0.0019
Schistosoma mansoni notch 0.0009 0.0003 0.0004
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0072 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.01 0.0143
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0006 0.0005
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1793 0.4185 0.5991
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0006 0.0005
Echinococcus multilocularis muscleblind protein 0.0624 0.1443 0.2063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0015 0.0019
Schistosoma mansoni hypothetical protein 0.1793 0.4185 0.5991
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0054 0.0074
Plasmodium falciparum plasmepsin II 0.0513 0.1185 0.2821
Brugia malayi AMP-binding enzyme family protein 0.0008 0 0.0001
Brugia malayi Importin beta-1 subunit 0.0028 0.0047 0.0068
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0072 0.021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus g protein coupled receptor 0.0014 0.0015 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0007 0.0004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0015 0.0019
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1375 0.3203 1
Toxoplasma gondii CBS domain-containing protein 0.0087 0.0185 0.0437
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0006 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0286 0.0839
Leishmania major inosine-5-monophosphate dehydrogenase 0.1461 0.3407 0.4877
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0015 0.0022
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0239 0.0339
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0267 0.0607 0.0844
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0015 0.0019
Schistosoma mansoni biogenic amine receptor 0.0014 0.0015 0.0022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0038 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0015 0.0013
Brugia malayi Cadherin domain containing protein 0.0009 0.0003 0.0004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0046 0.0133
Loa Loa (eye worm) hypothetical protein 0.0069 0.0143 0.014
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0038 0.0024
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0087 0.0185 0.0265
Onchocerca volvulus Peroxidase homolog 0.0069 0.0143 0.0999
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0069 0.0143 0.0174
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2988 0.6985 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0021 0.0044
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0015 0.0019
Echinococcus multilocularis peroxidasin 0.0072 0.0149 0.0211
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0015 0.0019
Schistosoma mansoni amine GPCR 0.0014 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0061 0.0058
Brugia malayi Hemopexin family protein 0.019 0.0426 0.0611
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0087 0.0185 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.004
Brugia malayi Peroxidasin 0.0072 0.0149 0.0214
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1793 0.4185 0.5991
Loa Loa (eye worm) hypothetical protein 0.0134 0.0295 0.0293
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0267 0.0607 0.0866
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1461 0.3407 0.4861
Onchocerca volvulus 0.0014 0.0015 0.0091
Plasmodium falciparum protein MAM3, putative 0.0087 0.0185 0.0429
Onchocerca volvulus 0.0262 0.0596 0.423
Brugia malayi CHE-14 protein 0.011 0.0239 0.0342
Schistosoma mansoni carbonic anhydrase 0.1793 0.4185 0.5991
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0006 0.0051
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0015 0.0022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0114 0.025 0.0247
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0015 0.0019
Plasmodium vivax importin-beta 2, putative 0.0028 0.0047 0.0129
Echinococcus granulosus carbonic anhydrase 0.1793 0.4185 0.599
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0003 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0006 0.0005
Plasmodium vivax plasmepsin IV, putative 0.0513 0.1185 0.3687
Echinococcus granulosus hypothetical protein 0.0014 0.0015 0.0019
Trypanosoma cruzi chloride channel protein, putative 0.0087 0.0185 0.0234
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0015 0.0019
Trichomonas vaginalis abcb9, putative 0.001 0.0006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0013
Echinococcus granulosus peroxidasin 0.0072 0.0149 0.0211
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0042 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0015 0.0022
Mycobacterium ulcerans transcriptional regulator 0.0087 0.0185 0.0543
Schistosoma mansoni hypothetical protein 0.0017 0.0022 0.0031
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1461 0.3407 0.4863
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.003 0.004
Brugia malayi aspartic protease BmAsp-2, identical 0.0178 0.04 0.0572
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0015 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0054 0.0078
Toxoplasma gondii aspartyl protease 0.0178 0.04 0.0949
Loa Loa (eye worm) matrix metalloproteinase 0.0134 0.0295 0.0293
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.1869 0.2673
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0046 0.0135
Onchocerca volvulus Peroxidasin homolog 0.0072 0.0149 0.1047
Echinococcus multilocularis sex peptide receptor 0.0014 0.0015 0.0019
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0038 0.0055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0015 0.0022
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0071 0.0149 0.0213
Plasmodium falciparum plasmepsin I 0.0513 0.1185 0.2821
Onchocerca volvulus 0.0014 0.0015 0.0091

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 164.5 nM Inhibition of human recombinant BACE1 ectodomain (1 to 460 amino acids) assessed as inhibition of proteolytic cleavage of Rhodamine-EVNLDAEFK-Quencher substrate after 35 mins by FRET assay ChEMBL. 21452857

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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