Detailed information for compound 1571610

Basic information

Technical information
  • TDR Targets ID: 1571610
  • Name: methyl 8-oxo-7-oxabicyclo[4.2.1]nonane-9-carb oxylate
  • MW: 198.216 | Formula: C10H14O4
  • H donors: 0 H acceptors: 2 LogP: 1.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1C2CCCCC1C(=O)O2
  • InChi: 1S/C10H14O4/c1-13-10(12)8-6-4-2-3-5-7(8)14-9(6)11/h6-8H,2-5H2,1H3
  • InChiKey: QNGYNLNQBVPUBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-oxo-7-oxabicyclo[4.2.1]nonane-9-carboxylic acid methyl ester
  • 8-keto-7-oxabicyclo[4.2.1]nonane-9-carboxylic acid methyl ester
  • 37746-07-9
  • NSC119513

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0068 0.0192 0.0192
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Brugia malayi putative neuropeptide receptor 0.0273 0.0995 0.0995
Loa Loa (eye worm) beta-tubulin 0.0178 0.0623 0.0623
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.0995 0.1435
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0026 0.0115
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0273 0.0995 0.1435
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0273 0.0995 0.0995
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.008 0.0114
Echinococcus multilocularis musashi 0.003 0.0044 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0118 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0396 0.0396
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0026 0.0115
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0019 0.0001 0.0001
Entamoeba histolytica tubulin family protein 0.0178 0.0623 0.5888
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1039 1
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0026 0.0026
Mycobacterium tuberculosis Hypothetical protein 0.02 0.0711 0.3985
Brugia malayi Pepsin A precursor 0.0068 0.0192 0.0192
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.008 0.0114
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0273 0.0995 0.1435
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0053
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0014 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0273 0.0995 0.1411
Echinococcus granulosus 7TM GPCR rhodopsin 0.0273 0.0995 0.1411
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.0995 0.1411
Loa Loa (eye worm) tubulin beta chain 0.0178 0.0623 0.0623
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Trypanosoma brucei calpain, putative 0.0109 0.0352 0.1566
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.017
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0253 0.0365
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.008 0.0114
Brugia malayi Eukaryotic aspartyl protease family protein 0.0068 0.0192 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0084 0.0121
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.0623 0.218
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Echinococcus granulosus MAM 0.0023 0.0015 0.0021
Onchocerca volvulus 0.0068 0.0192 0.0712
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0396 0.0396
Plasmodium falciparum plasmepsin V 0.0068 0.0192 0.0855
Onchocerca volvulus 0.02 0.0711 0.2637
Trypanosoma cruzi beta tubulin, putative 0.0178 0.0623 0.2771
Loa Loa (eye worm) hypothetical protein 0.0092 0.0286 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0133 0.0392
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0026 0.0037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.047 0.2312
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.0623 0.0883
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0244 0.0884 0.3134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0138 0.0409
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0273 0.0995 0.369
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0021
Plasmodium vivax aspartyl proteinase, putative 0.0068 0.0192 0.0852
Loa Loa (eye worm) TK/EGFR protein kinase 0.0142 0.0481 0.0481
Echinococcus multilocularis g protein coupled receptor 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0273 0.0995 0.369
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0273 0.0995 0.1435
Schistosoma mansoni biogenic amine receptor 0.0273 0.0995 0.1435
Schistosoma mansoni hypothetical protein 0.0071 0.0204 0.0295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0192 0.0855
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.0623 0.0883
Toxoplasma gondii aspartyl protease ASP3 0.0148 0.0505 0.2247
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0053 0.0133 0.059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0106
Entamoeba histolytica protein kinase, putative 0.0032 0.0052 0.0255
Schistosoma mansoni biogenic amine (5HT) receptor 0.0273 0.0995 0.1435
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0421 0.1575 0.2271
Echinococcus multilocularis serotonin receptor 0.0273 0.0995 0.1411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Echinococcus granulosus neuropeptide receptor 0.0273 0.0995 0.1411
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0176 0.0617 0.0875
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.008 0.0114
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.051 0.1925 0.1925
Loa Loa (eye worm) melatonin receptor type 1A 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Mycobacterium ulcerans thymidylate synthase 0.0421 0.1575 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.008 0.0114
Schistosoma mansoni alpha-1 adrenergic receptor 0.0273 0.0995 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0138 0.0409
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0054 0.0076
Brugia malayi Dopamine receptor protein 1 0.0273 0.0995 0.0995
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0273 0.0995 0.1411
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Brugia malayi hypothetical protein 0.0023 0.0015 0.0015
Brugia malayi map kinase activated protein kinase protein 2 0.0176 0.0617 0.0617
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.0623 0.0883
Plasmodium falciparum plasmepsin IX 0.0148 0.0505 0.2247
Onchocerca volvulus Neuropeptide F receptor homolog 0.0273 0.0995 0.369
Schistosoma mansoni amine GPCR 0.0273 0.0995 0.1435
Echinococcus multilocularis neuropeptide receptor 0.0273 0.0995 0.1411
Echinococcus granulosus neuropeptide receptor A26 0.0273 0.0995 0.1411
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.0623 0.218
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0273 0.0995 0.1411
Plasmodium falciparum subtilisin-like protease 3 0.0054 0.0138 0.0614
Loa Loa (eye worm) fibroinase 0.0025 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0083 0.0253 0.0365
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0026 0.0037
Onchocerca volvulus 0.0273 0.0995 0.369
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Brugia malayi Tachykinin-like peptides receptor 99D 0.0745 0.2847 0.2847
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0273 0.0995 0.1411
Leishmania major hypothetical protein, conserved 0.0022 0.0011 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0133 0.059
Brugia malayi neuroendocrine convertase 1 precursor 0.0748 0.2856 0.2856
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0084 0.0119
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0204 0.0204
Brugia malayi Subtilase family protein 0.0054 0.0138 0.0138
Brugia malayi hypothetical protein 0.02 0.0711 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Brugia malayi AKH receptor 0.0273 0.0995 0.0995
Echinococcus multilocularis sex peptide receptor 0.0273 0.0995 0.1411
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0273 0.0995 0.1411
Plasmodium vivax plasmepsin IV, putative 0.025 0.0907 0.4035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0053
Echinococcus multilocularis cathepsin L 0.0025 0.0026 0.0037
Schistosoma mansoni biogenic amine receptor 0.0273 0.0995 0.1435
Brugia malayi MH2 domain containing protein 0.0144 0.0491 0.0491
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0054 0.0138 0.0138
Loa Loa (eye worm) BEN-1 protein 0.0178 0.0623 0.0623
Trichomonas vaginalis hypothetical protein 0.0244 0.0884 0.3134
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Echinococcus multilocularis tubulin beta 1 chain 0.0178 0.0623 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0711 0.2501
Loa Loa (eye worm) hypothetical protein 0.0092 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0092 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Loa Loa (eye worm) hypothetical protein 0.0054 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Brugia malayi ephrin receptor 1 precursor 0.0098 0.0309 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0026 0.0096
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0176 0.0617 0.0617
Trypanosoma brucei C-8 sterol isomerase, putative 0.0369 0.1374 0.6113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0273 0.0995 0.0995
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Echinococcus multilocularis neuropeptide FF receptor 2 0.0745 0.2847 0.4039
Brugia malayi endoprotease bli-4 precursor 0.1173 0.4524 0.4524
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0044 0.0044
Echinococcus granulosus cathepsin L 0.0025 0.0026 0.0037
Schistosoma mansoni neuropeptide receptor 0.0273 0.0995 0.1435
Plasmodium vivax vivapain-2 0.0025 0.0026 0.0112
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0273 0.0995 0.0995
Plasmodium vivax vivapain-3 0.0025 0.0026 0.0112
Brugia malayi Tubulin beta-1 chain 0.0178 0.0623 0.0623
Onchocerca volvulus 0.0273 0.0995 0.369
Trichomonas vaginalis tubulin alpha chain, putative 0.0178 0.0623 0.218
Echinococcus multilocularis 0.0929 0.3567 0.5059
Brugia malayi SRC-1 0.0039 0.008 0.008
Loa Loa (eye worm) TK protein kinase 0.0036 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.025 0.0907 0.1287
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Onchocerca volvulus 0.0273 0.0995 0.369
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Schistosoma mansoni myosin xvIII 0.0273 0.0995 0.1435
Schistosoma mansoni tyrosine kinase 0.0142 0.0481 0.0694
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0118 0.0168
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0273 0.0995 0.0995
Echinococcus multilocularis neuropeptide s receptor 0.0273 0.0995 0.1411
Brugia malayi beta-tubulin, identical 0.0178 0.0623 0.0623
Brugia malayi hypothetical protein 0.0068 0.0192 0.0192
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0592 0.2247 1
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Echinococcus granulosus orexin receptor type 2 0.0273 0.0995 0.1411
Schistosoma mansoni cathepsin D (A01 family) 0.0809 0.3097 0.4465
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.0623 0.0883
Toxoplasma gondii cathepsin CPL 0.0025 0.0026 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Echinococcus granulosus endothelin converting enzyme 1 0.0092 0.0286 0.0406
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Echinococcus granulosus thymidylate synthase 0.0421 0.1575 0.2234
Schistosoma mansoni hypothetical protein 0.0083 0.0253 0.0365
Loa Loa (eye worm) hypothetical protein 0.02 0.0711 0.0711
Trichomonas vaginalis tubulin, putative 0.0178 0.0623 0.218
Schistosoma mansoni hypothetical protein 0.0189 0.0668 0.0963
Onchocerca volvulus 0.0273 0.0995 0.369
Schistosoma mansoni cathepsin D (A01 family) 0.0809 0.3097 0.4465
Leishmania major C-8 sterol isomerase-like protein 0.0369 0.1374 0.6113
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0014 0.002
Loa Loa (eye worm) brahma associated protein 0.0053 0.0133 0.0133
Brugia malayi neuropeptide F receptor 0.0273 0.0995 0.0995
Schistosoma mansoni hypothetical protein 0.0083 0.0253 0.0365
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.0623 0.0883
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0273 0.0995 0.1411
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0014 0.002
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0053 0.0133 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Plasmodium falciparum plasmepsin III 0.0068 0.0192 0.0855
Brugia malayi ORL1-like opioid receptor 0.0273 0.0995 0.0995
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.0623 0.0883
Trypanosoma brucei beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.0623 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0053 0.0133 0.0133
Echinococcus multilocularis fmrfamide receptor 0.0273 0.0995 0.1411
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus multilocularis g protein coupled receptor 0.0273 0.0995 0.1411
Toxoplasma gondii subtilisin SUB11 0.0054 0.0138 0.0614
Schistosoma mansoni neuropeptide f receptor 76f 0.0273 0.0995 0.1435
Schistosoma mansoni neuropeptide receptor 0.0273 0.0995 0.1435
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0054 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Brugia malayi Dopamine receptor 0.0273 0.0995 0.0995
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Entamoeba histolytica hypothetical protein 0.004 0.0084 0.0571
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni intermediate filament proteins 0.003 0.0044 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0118 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0617 0.089
Echinococcus multilocularis neuropeptide receptor 0.0273 0.0995 0.1411
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0273 0.0995 0.1411
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0369 0.1374 0.6113
Brugia malayi Protein kinase domain containing protein 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0273 0.0995 0.1435
Loa Loa (eye worm) tubulin beta-4 chain 0.0178 0.0623 0.0623
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.017
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.008 0.0114
Brugia malayi G-protein coupled receptor 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Echinococcus granulosus neuropeptide receptor 0.0273 0.0995 0.1411
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Schistosoma mansoni hypothetical protein 0.0273 0.0995 0.1435
Echinococcus granulosus dro:myosuppressin receptor 0.0273 0.0995 0.1411
Brugia malayi Protein kinase domain containing protein 0.0025 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Loa Loa (eye worm) ctsf protein 0.0025 0.0026 0.0026
Toxoplasma gondii subtilisin SUB8 0.0054 0.0138 0.0614
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0497 0.1875 0.1875
Echinococcus granulosus hypothetical protein 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Echinococcus multilocularis cysteine protease 0.0025 0.0026 0.0037
Onchocerca volvulus 0.003 0.0044 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Echinococcus granulosus cathepsin l1 0.0025 0.0026 0.0037
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0192 0.0192
Schistosoma mansoni amine GPCR 0.0273 0.0995 0.1435
Plasmodium falciparum plasmepsin II 0.025 0.0907 0.4037
Echinococcus multilocularis membrane bound transcription factor site 1 0.0054 0.0138 0.0196
Echinococcus multilocularis somatostatin receptor 0.0273 0.0995 0.1411
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Onchocerca volvulus 0.0273 0.0995 0.369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.025 0.0907 0.1287
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0273 0.0995 0.1435
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0192 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0724 0.2763 1
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0053 0.0053
Schistosoma mansoni neuropeptide F-like receptor 0.0273 0.0995 0.1435
Loa Loa (eye worm) hypothetical protein 0.2571 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0491 0.0491
Loa Loa (eye worm) tubulin beta-1 chain 0.0178 0.0623 0.0623
Echinococcus multilocularis tubulin subunit beta 0.0178 0.0623 0.0883
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0273 0.0995 0.0995
Brugia malayi celfurPC protein 0.0929 0.3567 0.3567
Echinococcus multilocularis g-protein coupled receptor 0.0273 0.0995 0.1411
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.008 0.0114
Echinococcus multilocularis endothelin converting enzyme 1 0.0092 0.0286 0.0406
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0064 0.0179 0.0796
Brugia malayi proprotein convertase 2 0.0748 0.2856 0.2856
Brugia malayi larval opioid receptor 0.0273 0.0995 0.0995
Echinococcus granulosus G protein coupled receptor 139 0.0273 0.0995 0.1411
Echinococcus multilocularis serotonin receptor 0.0273 0.0995 0.1411
Plasmodium vivax aspartyl proteinase, putative 0.025 0.0907 0.4035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0084 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Brugia malayi Kringle domain containing protein 0.0022 0.0011 0.0011
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0066 0.0094
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.017
Toxoplasma gondii subtilisin SUB10 0.0054 0.0138 0.0614
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni amine GPCR 0.0273 0.0995 0.1435
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0176 0.0617 0.0875
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0027 0.0038
Entamoeba histolytica hypothetical protein 0.004 0.0084 0.0571
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0011 0.0049
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Brugia malayi hypothetical protein 0.0025 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Echinococcus granulosus neuropeptides capa receptor 0.0273 0.0995 0.1411
Plasmodium vivax unspecified product 0.0245 0.0887 0.3946
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0273 0.0995 0.1411
Trypanosoma cruzi cruzipain precursor, putative 0.0025 0.0026 0.0115
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Plasmodium falciparum plasmepsin X 0.0148 0.0505 0.2247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0273 0.0995 0.1411
Echinococcus granulosus tyrosine kinase 0.0036 0.0066 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Echinococcus multilocularis SWI:SNF matrix associated 0.0053 0.0133 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0138 0.0409
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0192 0.0277
Plasmodium falciparum cysteine proteinase falcipain 1 0.0245 0.0887 0.3948
Echinococcus granulosus GPCR family 2 0.0049 0.0118 0.0168
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0253 0.0365
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.025 0.0907 0.1308
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0138 0.0409
Echinococcus granulosus tm gpcr rhodopsin 0.1818 0.705 1
Loa Loa (eye worm) hypothetical protein 0.0449 0.1687 0.1687
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0253 0.0359
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.0995 0.1411
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0083 0.0253 0.0253
Onchocerca volvulus 0.0273 0.0995 0.369
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Echinococcus granulosus peptide allatostatin:somatostatin 0.0273 0.0995 0.1411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0396 0.0396
Schistosoma mansoni hypothetical protein 0.0273 0.0995 0.1435
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0066 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Echinococcus multilocularis ephrin type A receptor 4 A 0.0203 0.0724 0.1027
Plasmodium vivax plasmepsin V, putative 0.0068 0.0192 0.0852
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0016
Trypanosoma cruzi subtilisin peptidase 0.0054 0.0138 0.0614
Plasmodium vivax vivapain-1 0.0245 0.0887 0.3946
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0592 0.2247 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0026 0.0026
Onchocerca volvulus 0.0273 0.0995 0.369
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0045 0.0105 0.0105
Schistosoma mansoni opsin-like receptor 0.0273 0.0995 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Trypanosoma brucei beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.0995 0.1435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0053 0.0133 0.0189
Loa Loa (eye worm) thymidylate synthase 0.0421 0.1575 0.1575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0192 0.0376
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0592 0.2247 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0026 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0273 0.0995 0.1435
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.0623 0.0883
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0396 0.0396
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Schistosoma mansoni hypothetical protein 0.0273 0.0995 0.1435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1173 0.4524 0.6524
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1039 1
Schistosoma mansoni serine-type protease inhibitor 0.1789 0.6935 1
Brugia malayi GnHR receptor homolog 0.0273 0.0995 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0273 0.0995 0.1435
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0192 0.0192
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0244 0.0884 0.3134
Schistosoma mansoni hypothetical protein 0.0273 0.0995 0.1435
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0244 0.0884 0.3134
Giardia lamblia Furin precursor putative serine protease 0.0244 0.0884 0.2688
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.0623 0.0883
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0092 0.0286 0.0286
Onchocerca volvulus 0.0025 0.0026 0.0096
Echinococcus granulosus neuropeptide s receptor 0.0273 0.0995 0.1411
Brugia malayi Serotonin receptor 0.0273 0.0995 0.0995
Entamoeba histolytica tubulin family protein 0.0178 0.0623 0.5888
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi SWIB/MDM2 domain containing protein 0.0053 0.0133 0.0133
Schistosoma mansoni memapsin-2 (A01 family) 0.0068 0.0192 0.0277
Onchocerca volvulus 0.0053 0.0133 0.0494
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.02 0.0711 0.3163
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0053 0.0133 0.0593
Echinococcus granulosus tubulin beta 4A class IVa 0.0178 0.0623 0.0883
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Brugia malayi G protein-coupled receptor F59B2.13 0.0273 0.0995 0.0995
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0118 0.0168
Toxoplasma gondii peptidase family M13 protein 0.0092 0.0286 0.1273
Schistosoma mansoni tgf-beta family 0.0032 0.0053 0.0077
Brugia malayi brahma associated protein 60 kDa 0.0053 0.0133 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0273 0.0995 0.0995
Toxoplasma gondii aspartyl protease ASP1 0.025 0.0907 0.4037
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0138 0.0409
Echinococcus multilocularis dihydrofolate reductase 0.0172 0.0599 0.0849
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni site-1 peptidase (S08 family) 0.0054 0.0138 0.0199
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0068 0.0192 0.0192
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0019 0.0001 0.0001
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0172 0.0599 0.3206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0273 0.0995 0.1435
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Brugia malayi peptidase family M13 containing protein 0.0022 0.0014 0.0014
Onchocerca volvulus 0.0032 0.0053 0.0197
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0026 0.0115
Mycobacterium leprae probable zinc metalloprotease 0.0092 0.0286 0.103
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0192 0.0277
Schistosoma mansoni hypothetical protein 0.0244 0.0884 0.1275
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0011 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Toxoplasma gondii subtilisin SUB5 0.0054 0.0138 0.0614
Plasmodium falciparum subtilisin-like protease 1 0.0054 0.0138 0.0614
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) intermediate filament protein 0.003 0.0044 0.0044
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0108 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0045 0.0105 0.0388
Onchocerca volvulus 0.0273 0.0995 0.369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Schistosoma mansoni lamin 0.003 0.0044 0.0064
Echinococcus multilocularis beta tubulin 0.0178 0.0623 0.0883
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.047 0.2312
Echinococcus multilocularis tgf beta family 0.0032 0.0053 0.0075
Echinococcus granulosus alpha 1A adrenergic receptor 0.0273 0.0995 0.1411
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.0352 0.1566
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0026 0.0037
Onchocerca volvulus 0.003 0.0044 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) bone morphogenic protein 6 0.0126 0.0422 0.0422
Brugia malayi protein-tyrosine kinase 0.0036 0.0066 0.0066
Plasmodium vivax aspartyl protease, putative 0.0148 0.0505 0.2244
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0273 0.0995 0.1411
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0026 0.0037
Chlamydia trachomatis dihydrofolate reductase 0.0172 0.0599 1
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Echinococcus granulosus neuroendocrine convertase 2 0.0748 0.2856 0.4051
Onchocerca volvulus 0.0025 0.0026 0.0096
Echinococcus granulosus SWI:SNF matrix associated 0.0053 0.0133 0.0189
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0192 0.0272
Echinococcus granulosus g protein coupled receptor 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Trichomonas vaginalis tubulin gamma chain, putative 0.0178 0.0623 0.218
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0026 0.0026
Brugia malayi G protein-coupled receptor 0.0273 0.0995 0.0995
Echinococcus granulosus g protein coupled receptor 0.0273 0.0995 0.1411
Echinococcus multilocularis neuropeptide receptor A26 0.0273 0.0995 0.1411
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1537 0.2181
Echinococcus granulosus neuropeptide Y receptor 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0273 0.0995 0.369
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0273 0.0995 0.1435
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0109 0.0352 0.1566
Loa Loa (eye worm) cysteine protease 0.0025 0.0026 0.0026
Loa Loa (eye worm) aspartyl protease 6 0.0068 0.0192 0.0192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0273 0.0995 0.1411
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0092 0.0286 0.103
Onchocerca volvulus 0.0273 0.0995 0.369
Schistosoma mansoni opsin-like receptor 0.0273 0.0995 0.1435
Trypanosoma brucei hypothetical protein 0.0109 0.0352 0.1566
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) G-protein coupled receptor 0.0273 0.0995 0.0995
Plasmodium falciparum tubulin beta chain 0.0178 0.0623 0.2771
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0118 0.0168
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0066 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Brugia malayi putative neuropeptide receptor NPR1 0.0273 0.0995 0.0995
Plasmodium vivax vivapain-2 0.0025 0.0026 0.0112
Onchocerca volvulus 0.0025 0.0026 0.0096
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0592 0.2247 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0192 0.0376
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Echinococcus granulosus biogenic amine 5HT receptor 0.0273 0.0995 0.1411
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi G-protein coupled receptor 0.0273 0.0995 0.0995
Schistosoma mansoni amine GPCR 0.0273 0.0995 0.1435
Echinococcus granulosus tgf beta family 0.0032 0.0053 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1308 0.4684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Plasmodium vivax tubulin beta chain, putative 0.0178 0.0623 0.2769
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0298 0.1095 0.158
Echinococcus granulosus fmrfamide receptor 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0273 0.0995 0.369
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0014 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0724 0.2763 0.392
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Loa Loa (eye worm) LjBmp2/4b 0.0032 0.0053 0.0053
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0421 0.1575 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0011 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Brugia malayi thymidylate synthase 0.0421 0.1575 0.1575
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0273 0.0995 0.1435
Schistosoma mansoni hypothetical protein 0.0053 0.0133 0.0192
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0126 0.0422 0.0599
Echinococcus multilocularis bone morphogenetic protein 2 0.0032 0.0053 0.0075
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0054 0.0138 0.0199
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0011 0.0049
Echinococcus multilocularis G-protein coupled receptor, putative 0.0273 0.0995 0.1411
Brugia malayi Dihydrofolate reductase 0.0172 0.0599 0.0599
Echinococcus granulosus neuropeptide Y receptor 0.0273 0.0995 0.1411
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0273 0.0995 0.1411
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0024 0.0103
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0052 0.0073
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0026 0.0115
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0053 0.0133 0.0593
Onchocerca volvulus 0.0273 0.0995 0.369
Echinococcus multilocularis thymidylate synthase 0.0421 0.1575 0.2234
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni brg-1 associated factor 0.0053 0.0133 0.0192
Plasmodium falciparum subtilisin-like protease 2 0.0054 0.0138 0.0614
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Loa Loa (eye worm) TK protein kinase 0.0032 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.047 0.2312
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.025 0.0907 0.3219
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Loa Loa (eye worm) aspartic protease BmAsp-2 0.025 0.0907 0.0907
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0054 0.0138 0.0199
Loa Loa (eye worm) endoprotease bli-4 0.1173 0.4524 0.4524
Plasmodium vivax subtilisin-like serine protease, putative 0.0054 0.0138 0.0611
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.051 0.1925 0.1925
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0108 0.0156
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0192 0.0855
Loa Loa (eye worm) subtilase 0.0054 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) TK/ALK protein kinase 0.0026 0.0028 0.0028
Brugia malayi follicle stimulating hormone receptor 0.0497 0.1875 0.1875
Echinococcus granulosus g-protein coupled receptor 0.0273 0.0995 0.1411
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0273 0.0995 0.0995
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.0623 0.218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Toxoplasma gondii subtilisin SUB4 0.0054 0.0138 0.0614
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.002 0.0029
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0707 0.2696 0.3888
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Plasmodium falciparum plasmepsin I 0.025 0.0907 0.4037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.0995 0.1435
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0369 0.1374 0.1374
Loa Loa (eye worm) hypothetical protein 0.0745 0.2847 0.2847
Loa Loa (eye worm) TK/EPH protein kinase 0.0258 0.0939 0.0939
Onchocerca volvulus 0.0068 0.0192 0.0712
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0108 0.0156
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1039 0.4288
Echinococcus granulosus ephrin type A receptor 4 A 0.0203 0.0724 0.1027
Plasmodium vivax subtilisin-like protease 1 0.0054 0.0138 0.0611
Schistosoma mansoni hypothetical protein 0.0053 0.0133 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Toxoplasma gondii subtilisin SUB12 0.0068 0.0193 0.0858
Echinococcus multilocularis lamin dm0 0.003 0.0044 0.0063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0026 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1537 0.2181
Onchocerca volvulus 0.0025 0.0026 0.0096
Loa Loa (eye worm) hypothetical protein 0.0707 0.2696 0.2696
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni tubulin subunit beta 0.0178 0.0623 0.0898
Plasmodium falciparum plasmepsin VIII, putative 0.0068 0.0192 0.0855
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Brugia malayi neuropeptide F receptor 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0118
Onchocerca volvulus 0.0273 0.0995 0.369
Plasmodium falciparum plasmepsin IV 0.025 0.0907 0.4037
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.0106
Echinococcus granulosus somatostatin receptor 0.0273 0.0995 0.1411
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0592 0.2247 1
Loa Loa (eye worm) SRC-1 0.0039 0.008 0.008
Onchocerca volvulus 0.0273 0.0995 0.369
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Brugia malayi Serotonin receptor 0.0273 0.0995 0.0995
Echinococcus granulosus g protein coupled receptor 0.0273 0.0995 0.1411
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.0106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0044 0.0044
Onchocerca volvulus 0.0421 0.1575 0.5841
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Echinococcus granulosus beta tubulin 0.0178 0.0623 0.0883
Brugia malayi sulfakinin receptor protein 0.2571 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0082 0.0117
Loa Loa (eye worm) hypothetical protein 0.1173 0.4524 0.4524
Schistosoma mansoni furin-1 (S08 family) 0.0503 0.1899 0.2738
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus multilocularis SWI:SNF matrix associated 0.0053 0.0133 0.0189
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0064 0.0179 0.0796
Brugia malayi hypothetical protein 0.004 0.0084 0.0084
Brugia malayi dihydrofolate reductase family protein 0.0172 0.0599 0.0599
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0273 0.0995 0.0995
Schistosoma mansoni hypothetical protein 0.0411 0.1537 0.2217
Brugia malayi Melatonin receptor type 1A 0.0273 0.0995 0.0995
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0026 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0491 0.0491
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0253 0.0253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Schistosoma mansoni adenoreceptor 0.0273 0.0995 0.1435
Onchocerca volvulus 0.0025 0.0026 0.0096
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.0623 0.0883
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0109 0.0352 0.1566
Echinococcus granulosus dihydrofolate reductase 0.0172 0.0599 0.0849
Schistosoma mansoni hypothetical protein 0.0049 0.0118 0.017
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.0198
Echinococcus granulosus epidermal growth factor receptor 0.0142 0.0481 0.0683
Echinococcus granulosus serotonin receptor 0.0273 0.0995 0.1411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0369 0.1374 0.1374
Loa Loa (eye worm) TYRA-2 protein 0.0273 0.0995 0.0995
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Toxoplasma gondii beta-1 tubulin, putative 0.0178 0.0623 0.2771
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0273 0.0995 0.1411
Brugia malayi hypothetical protein 0.0032 0.0053 0.0053
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.1238 0.459
Loa Loa (eye worm) BEN-1 protein 0.0178 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Loa Loa (eye worm) neuropeptide F receptor 0.0273 0.0995 0.0995
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0026 0.0115
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.1238 0.4426
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0109 0.0352 0.1566
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0053 0.0133 0.0593
Echinococcus granulosus sex peptide receptor 0.0273 0.0995 0.1411
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0273 0.0995 0.0995
Echinococcus granulosus cysteine protease 0.0025 0.0026 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0026 0.0115
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0273 0.0995 0.1411
Schistosoma mansoni tyrosine kinase 0.0039 0.008 0.0116
Echinococcus multilocularis allatostatin A receptor 0.0707 0.2696 0.3824
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0026 0.0096
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0066 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0026 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0192 0.0277
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0724 0.2763 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0273 0.0995 0.1411
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus granulosus beta tubulin 0.0178 0.0623 0.0883
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0192 0.0272
Echinococcus multilocularis cysteine protease 0.0025 0.0026 0.0037
Loa Loa (eye worm) proprotein convertase 2 0.0298 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi aspartic protease BmAsp-2, identical 0.0068 0.0192 0.0192
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0126 0.0422 0.0599
Leishmania major subtilisin-like serine peptidase 0.0054 0.0138 0.0614
Toxoplasma gondii subtilisin SUB6 0.0054 0.0138 0.0614
Echinococcus granulosus neuropeptides capa receptor 0.0273 0.0995 0.1411
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0253 0.0359
Echinococcus granulosus tubulin beta 1 chain 0.0178 0.0623 0.0883
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.0352 0.1566
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0066 0.0094
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0273 0.0995 0.1435
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0054 0.0138 0.0196
Echinococcus multilocularis Furin 1 0.0298 0.1095 0.1554
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0189 0.0666 0.0666
Trypanosoma brucei beta tubulin 0.0178 0.0623 0.2771
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Plasmodium falciparum plasmepsin VI 0.025 0.0907 0.4037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Onchocerca volvulus 0.0021 0.0008 0.003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0026 0.0037
Schistosoma mansoni neuropeptide receptor 0.0273 0.0995 0.1435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.025 0.0907 0.4037
Toxoplasma gondii subtilisin SUB2 0.0054 0.0138 0.0614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Entamoeba histolytica hypothetical protein 0.004 0.0084 0.0571
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0253 0.0253
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0014 0.002
Trypanosoma brucei RNA helicase, putative 0.0421 0.1577 0.7018
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0044
Giardia lamblia High cysteine membrane protein Group 2 0.0426 0.1594 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0052 0.0073
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Loa Loa (eye worm) hypothetical protein 0.0071 0.0204 0.0204
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Schistosoma mansoni growth hormone secretagogue receptor 0.0273 0.0995 0.1435
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.008 0.0114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0026 0.0115
Loa Loa (eye worm) dihydrofolate reductase 0.0172 0.0599 0.0599
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus granulosus geminin 0.0189 0.0668 0.0947
Schistosoma mansoni dihydrofolate reductase 0.0172 0.0599 0.0863
Toxoplasma gondii aspartyl protease 0.0068 0.0192 0.0855
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0026 0.0037
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0014 0.0014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0108 0.0156
Toxoplasma gondii subtilisin SUB7 0.0054 0.0138 0.0614
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0273 0.0995 0.369
Echinococcus granulosus furin 0.1173 0.4524 0.6417
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Echinococcus multilocularis geminin 0.0189 0.0668 0.0947
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0421 0.1575 1
Brugia malayi brahma associated protein 60 kDa 0.0053 0.0133 0.0133
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0172 0.0599 0.3206
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0011 0.0016
Schistosoma mansoni neprilysin 0.0024 0.002 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus multilocularis g protein coupled receptor 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0707 0.2696 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Onchocerca volvulus 0.0025 0.0026 0.0096
Schistosoma mansoni hypothetical protein 0.0024 0.002 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Brugia malayi Furin-like cysteine rich region family protein 0.0142 0.0481 0.0481
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0026 0.0037
Mycobacterium ulcerans zinc metalloprotease 0.0092 0.0286 0.103
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0118 0.0118
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Schistosoma mansoni hypothetical protein 0.0421 0.1577 0.2274
Loa Loa (eye worm) G-protein coupled receptor 0.0273 0.0995 0.0995
Loa Loa (eye worm) tubulin beta-2A chain 0.0178 0.0623 0.0623
Plasmodium vivax unspecified product 0.0229 0.0823 0.3662
Plasmodium vivax aspartyl protease, putative 0.0068 0.0192 0.0852
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1039 0.3702
Onchocerca volvulus 0.0054 0.0138 0.0512
Onchocerca volvulus 0.003 0.0044 0.0165
Echinococcus granulosus Furin 1 0.0298 0.1095 0.1554
Echinococcus granulosus lamin dm0 0.003 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Echinococcus granulosus intermediate filament protein 0.003 0.0044 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0026 0.0115
Schistosoma mansoni histamine h1 receptor 0.0273 0.0995 0.1435
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.0352 0.1566
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0014 0.002
Schistosoma mansoni serine-type protease inhibitor 0.1789 0.6935 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.0118 0.0168
Echinococcus multilocularis dro:myosuppressin receptor 0.0273 0.0995 0.1411
Toxoplasma gondii beta tubulin 0.0178 0.0623 0.2771
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Schistosoma mansoni neuropeptide receptor 0.0273 0.0995 0.1435
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0054 0.0138 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Brugia malayi RE15519p 0.0273 0.0995 0.0995
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0026 0.0115
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0178 0.0623 0.0883
Brugia malayi hypothetical protein 0.0273 0.0995 0.0995
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0011 0.0046
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0172 0.0599 0.3206
Toxoplasma gondii subtilisin SUB1 0.0054 0.0138 0.0614
Trypanosoma brucei beta tubulin 0.0178 0.0623 0.2771
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0273 0.0995 0.1411
Trypanosoma brucei subtilisin peptidase 0.0054 0.0138 0.0614
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0054 0.0138 0.0138
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0026 0.0115
Echinococcus multilocularis G protein coupled receptor 139 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0011
Echinococcus multilocularis neuroendocrine convertase 2 0.0748 0.2856 0.4051
Echinococcus granulosus tachykinin peptides receptor 99D 0.0273 0.0995 0.1411
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0298 0.1095 0.3907
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0068 0.0192 0.0855
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0064 0.0179 0.0796
Brugia malayi aspartic protease BmAsp-1, identical 0.0068 0.0192 0.0192
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.008 0.0114
Schistosoma mansoni hypothetical protein 0.0189 0.0668 0.0963
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1039 0.5
Echinococcus multilocularis orexin receptor type 2 0.0273 0.0995 0.1411
Loa Loa (eye worm) growth/differentiation factor 10 0.0032 0.0053 0.0053
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0286 0.0412
Schistosoma mansoni lamin 0.003 0.0044 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.0995 0.1411
Echinococcus granulosus bone morphogenetic protein 2 0.0032 0.0053 0.0075
Echinococcus granulosus lamin 0.003 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0102 0.0326 0.0326
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0592 0.2247 1
Plasmodium vivax aspartyl protease, putative 0.0148 0.0505 0.2244
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0026 0.0115
Schistosoma mansoni opsin-like receptor 0.0273 0.0995 0.1435
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.008 0.0114
Brugia malayi Dopamine receptor protein 2 0.0273 0.0995 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0109 0.0352 0.1566
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0026 0.0096
Schistosoma mansoni amine GPCR 0.0273 0.0995 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0884 0.3134
Brugia malayi hypothetical protein 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Leishmania major cathepsin L-like protease 0.0025 0.0026 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0192 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0026 0.0115
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0724 0.2763 0.392
Brugia malayi Cathepsin L-like precursor 0.0025 0.0026 0.0026
Trypanosoma brucei calpain-like protein, putative 0.0109 0.0352 0.1566
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0273 0.0995 0.1411
Loa Loa (eye worm) neuropeptide F receptor 0.0273 0.0995 0.0995
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0253 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Schistosoma mansoni tgf-beta family 0.0032 0.0053 0.0077
Onchocerca volvulus 0.0032 0.0053 0.0197
Echinococcus granulosus allatostatin A receptor 0.0707 0.2696 0.3824
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1308 0.4684
Echinococcus multilocularis neuropeptide Y receptor 0.0273 0.0995 0.1411
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0026 0.0115
Echinococcus multilocularis MAM 0.0023 0.0015 0.0021
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.008 0.0114
Echinococcus granulosus neuropeptide FF receptor 2 0.0745 0.2847 0.4039
Echinococcus granulosus biogenic amine 5HT receptor 0.0273 0.0995 0.1411
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0273 0.0995 0.1411
Echinococcus multilocularis lamin 0.003 0.0044 0.0063
Onchocerca volvulus 0.0022 0.0011 0.0041
Schistosoma mansoni ephrin receptor 0.0203 0.0724 0.1044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0054 0.0138 0.0409
Echinococcus granulosus 7tm_1 domain containing protein 0.0273 0.0995 0.1411
Echinococcus granulosus tubulin subunit beta 0.0178 0.0623 0.0883
Onchocerca volvulus 0.0025 0.0026 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Echinococcus multilocularis beta tubulin 0.0178 0.0623 0.0883
Schistosoma mansoni site-1 peptidase (S08 family) 0.0054 0.0138 0.0199
Plasmodium falciparum plasmepsin VII 0.0068 0.0192 0.0855
Schistosoma mansoni hypothetical protein 0.004 0.0084 0.0121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.0995 0.1411
Schistosoma mansoni biogenic amine receptor 0.0273 0.0995 0.1435
Schistosoma mansoni tyrosine kinase 0.0039 0.008 0.0116
Echinococcus multilocularis epidermal growth factor receptor 0.0142 0.0481 0.0683
Plasmodium vivax subtilisin-like protease 2, putative 0.0054 0.0138 0.0611
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0106
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0253 0.0359
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0054 0.0138 0.0614
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0118 0.0118
Brugia malayi Transforming growth factor beta like domain containing protein 0.0126 0.0422 0.0422
Toxoplasma gondii subtilisin SUB9 0.0054 0.0138 0.0614
Echinococcus granulosus membrane bound transcription factor site 1 0.0054 0.0138 0.0196
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0026 0.0115
Entamoeba histolytica hypothetical protein 0.004 0.0084 0.0571
Brugia malayi Peptidase family M13 containing protein 0.0092 0.0286 0.0286
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.025 0.0907 0.0907
Schistosoma mansoni hypothetical protein 0.0053 0.0133 0.0192
Onchocerca volvulus 0.0035 0.0065 0.0242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1818 0.705 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0053 0.0133 0.0189
Brugia malayi intermediate filament protein 0.003 0.0044 0.0044
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0026 0.0037
Leishmania major beta tubulin 0.0178 0.0623 0.2771
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.0352 0.1566
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.1925 0.6936
Loa Loa (eye worm) hypothetical protein 0.0068 0.0192 0.0192
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0108 0.0156
Onchocerca volvulus 0.0023 0.0015 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.0995 0.1435
Loa Loa (eye worm) hypothetical protein 0.0273 0.0995 0.0995
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0053 0.0133 0.0593
Toxoplasma gondii beta-tubulin, putative 0.0178 0.0623 0.2771

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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