Detailed information for compound 1573358

Basic information

Technical information
  • TDR Targets ID: 1573358
  • Name: N-[2-[4-(2,3-dimethylphenyl)piperazin-1-yl]et hyl]chroman-3-carboxamide
  • MW: 393.522 | Formula: C24H31N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1COc2c(C1)cccc2)NCCN1CCN(CC1)c1cccc(c1C)C
  • InChi: 1S/C24H31N3O2/c1-18-6-5-8-22(19(18)2)27-14-12-26(13-15-27)11-10-25-24(28)21-16-20-7-3-4-9-23(20)29-17-21/h3-9,21H,10-17H2,1-2H3,(H,25,28)
  • InChiKey: WMYQLWSEXZIOBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[4-(2,3-dimethylphenyl)-1-piperazinyl]ethyl]-3-chromancarboxamide
  • G668-0288
  • NCGC00132585-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0125 0.1471 0.2589
Loa Loa (eye worm) hypothetical protein 0.0032 0.0309 0.0521
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0045 0.0139
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0152 0.1808 0.3167
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0017 0.0122 0.0368
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0218 0.1093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.009 0.0136
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0045 0.0063
Schistosoma mansoni chromobox protein 0.0011 0.0045 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Brugia malayi hypothetical protein 0.0076 0.0851 0.1498
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0567 0.1741
Brugia malayi nuclear receptor NHR-67 0.0029 0.0271 0.0477
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0424 0.19
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.068 0.1197
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0112 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.1993 1
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0309 0.0294
Loa Loa (eye worm) D-ets-2 protein 0.0022 0.0182 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0455 0.2059
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0533
Schistosoma mansoni hypothetical protein 0.0079 0.0898 0.158
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0413 0.1886
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0106 0.0258
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0106 0.0258
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0672 0.3373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.068 0.1362
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0017 0.0122 0.0368
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.002 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1471 0.2589
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0103 0.0088
Trypanosoma brucei polo-like protein kinase 0.0106 0.1235 0.6089
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.1993 1
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0271 0.0477
Schistosoma mansoni alpha-glucosidase 0.0157 0.1871 0.3293
Schistosoma mansoni elf1 0.0022 0.0182 0.032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0143 0.0251
Brugia malayi MH2 domain containing protein 0.0009 0.002 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0271 0.0525
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.068 0.1197
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0312 0.0549
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0533 0.2506
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.1993 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0056 0.0076
Entamoeba histolytica hypothetical protein 0.0076 0.0851 0.4138
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0218 0.0674
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1224 0.6141
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0533 0.2677
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0365 0.0351
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.009 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.068 0.1197
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0413 0.1267
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.1235 0.6016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0413 0.1886
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.068 0.1197
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.068 0.3209
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1471 0.2589
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0413 0.184
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1371 0.6878
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0263 0.1116
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0271 0.0525
Echinococcus multilocularis GA binding protein alpha chain 0.0152 0.1808 0.1796
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0365 0.0717
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.068 0.1362
Brugia malayi AMP-binding enzyme family protein 0.001 0.0028 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0533 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0309 0.0602
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0383 0.1708
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0022 0.0182 0.0168
Loa Loa (eye worm) hypothetical protein 0.009 0.1034 0.1801
Echinococcus multilocularis Smad4 0.0009 0.002 0.0005
Schistosoma mansoni chromobox protein 0.0068 0.0757 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0315 0.0554
Brugia malayi AMP-binding enzyme family protein 0.0015 0.009 0.0159
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0045 0.0139
Schistosoma mansoni zinc finger protein 0.0029 0.0271 0.0477
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0672 0.318
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.1021 0.1779
Brugia malayi AMP-binding enzyme family protein 0.0015 0.009 0.0159
Schistosoma mansoni hypothetical protein 0.0041 0.0413 0.0727
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0471
Brugia malayi ShTK domain containing protein 0.009 0.1034 0.182
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.1055 0.2129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0218 0.0674
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0375 0.1424
Schistosoma mansoni kinase 0.0054 0.0584 0.1029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0045 0.0139
Schistosoma mansoni netrin receptor unc5 0.0032 0.0309 0.0543
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.009 0.0453
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0851 0.1498
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0125 0.0383
Entamoeba histolytica hypothetical protein 0.0013 0.0069 0.0122
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0056 0.0167
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0161 0.0808
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0413 0.184
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0022 0.0182 0.0298
Onchocerca volvulus 0.0011 0.0045 0.00000011801
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0095 0.0198
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0208 0.1045
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1471 0.2589
Loa Loa (eye worm) ets-domain-containing protein 0.0022 0.0182 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.1357 0.2388
Schistosoma mansoni nuclear receptor 0.0029 0.0271 0.0477
Loa Loa (eye worm) glutaminase 2 0.0268 0.3257 0.5723
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0365 0.0643
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0381 0.0671
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.1993 0.6115
Schistosoma mansoni tsg101-related 0.0053 0.0569 0.1001
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0271 0.0477
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.068 0.1362
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Loa Loa (eye worm) hypothetical protein 0.0116 0.1357 0.237
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.1993 1
Schistosoma mansoni hypothetical protein 0.0037 0.0365 0.0643
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.068 0.1197
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1235 0.6089
Loa Loa (eye worm) hypothetical protein 0.0078 0.088 0.153
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1658 0.3362
Schistosoma mansoni nuclear receptor 0.0029 0.0271 0.0477
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.009 0.0231
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1021 0.4984
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0069 0.0067
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0049 0.0064
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0045 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.068 0.1177
Echinococcus granulosus Chromobox protein 3 0.0011 0.0045 0.0063
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0271 0.0477
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.2189 0.3838
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.009 0.0231
Echinococcus multilocularis expressed conserved protein 0.0092 0.1057 0.1044
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1579 0.2762
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0413 0.1267
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0095 0.0254
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0533 0.1633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.068 0.0666
Schistosoma mansoni nuclear hormone receptor 0.0062 0.068 0.1197
Echinococcus granulosus tar DNA binding protein 0.0125 0.1471 0.298
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0484 0.083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.009 0.0271
Echinococcus granulosus ETS transcription factor Elf 2 0.0022 0.0182 0.0343
Trypanosoma brucei unspecified product 0.0013 0.0069 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1471 0.2589
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0017 0.0122 0.0371
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0413 0.2071
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0315 0.0533
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0112 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0053 0.0093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.024
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1034 0.182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0144
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0271 0.0477
Onchocerca volvulus 0.0015 0.009 0.0227
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.1993 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1371 0.4307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.068 0.1177
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1235 0.6089
Brugia malayi glutaminase DH11.1 0.0268 0.3257 0.5733
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0143 0.0716
Brugia malayi steroid hormone receptor 0.0062 0.068 0.1197
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0218 0.0833
Brugia malayi hypothetical protein 0.0025 0.022 0.0387
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0432 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1235 0.2174
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0143 0.0251
Schistosoma mansoni smad1 5 8 and 0.0009 0.002 0.0035
Schistosoma mansoni hypothetical protein 0.0032 0.0309 0.0543
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0045 0.0031
Brugia malayi nuclear receptor RXR 0.0033 0.0315 0.0554
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0533
Echinococcus multilocularis kelch ECH associated protein 1 0.0106 0.1229 0.1216
Schistosoma mansoni gabp alpha 0.0152 0.1808 0.3183
Mycobacterium ulcerans polyketide synthase 0.0025 0.0218 0.0663
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0484 0.2207
Echinococcus granulosus FTZ F1 alpha 0.0062 0.068 0.1362
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.2189 0.3852
Echinococcus multilocularis smad 0.0009 0.002 0.0005
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0009 0.0013 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0365 0.0351
Brugia malayi hypothetical protein 0.0072 0.0809 0.1423
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.009 0.0231
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.068 0.0666
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.1034 0.182
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0533 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0106 0.0313
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0143 0.0716
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0237 0.119
Brugia malayi hypothetical protein 0.0029 0.0271 0.0477
Loa Loa (eye worm) hypothetical protein 0.0088 0.1011 0.1761
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1371 0.6878
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.009 0.0453
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1471 0.2589
Onchocerca volvulus 0.0058 0.0633 0.297
Onchocerca volvulus 0.0012 0.0053 0.0039
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0533 0.1633
Onchocerca volvulus 0.0106 0.1226 0.5971
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1034 0.182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Trichomonas vaginalis glutaminase, putative 0.0268 0.3257 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0271 0.0525
Schistosoma mansoni thyroid hormone receptor 0.0062 0.068 0.1197
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0271 0.0257
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0413 0.1267
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0237 0.0735
Brugia malayi Ets-domain containing protein 0.0152 0.1808 0.3183
Entamoeba histolytica hypothetical protein 0.0013 0.0069 0.0122
Brugia malayi transcription factor E74 isoform 0.0022 0.0182 0.032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.068 0.1197
Brugia malayi hypothetical protein 0.0169 0.2023 0.3561
Brugia malayi nuclear receptor RXR 0.0029 0.0271 0.0477
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.068 0.3209
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0106 0.0313
Entamoeba histolytica hypothetical protein 0.0076 0.0851 0.4138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0143 0.0128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Brugia malayi Ets-domain containing protein 0.0022 0.0182 0.032
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.009 0.0155
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0004 0.002
Brugia malayi Ets-domain containing protein 0.0152 0.1808 0.3183
Onchocerca volvulus 0.009 0.1034 0.4999
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.1993 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0095 0.0291
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.024
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0103 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1471 0.2572
Brugia malayi SET domain containing protein 0.0012 0.0053 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0365 0.0621
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.1235 0.2174
Trichomonas vaginalis hypothetical protein 0.0038 0.0381 0.1169
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0065 0.0104
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0315 0.0554
Echinococcus granulosus chromobox protein 2 0.0011 0.0045 0.0063
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0533 0.2677
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Echinococcus granulosus GA binding protein alpha chain 0.0152 0.1808 0.367
Leishmania major cytochrome p450-like protein 0.0012 0.0056 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.068 0.1197
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1224 0.3844
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0143 0.0432
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Schistosoma mansoni alpha-glucosidase 0.0157 0.1871 0.3293
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0757 0.2324
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0103 0.0181
Schistosoma mansoni hypothetical protein 0.0022 0.0182 0.032
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0103 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0413 0.1267
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0309 0.1331
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0015 0.0003
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0166 0.051
Schistosoma mansoni cpg binding protein 0.003 0.0277 0.0487
Echinococcus multilocularis protein patched 0.0042 0.0432 0.0418
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0424 0.1302
Brugia malayi nuclear receptor NHR-88 0.0062 0.068 0.1197
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0069 0.0212
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.002 0.0012
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0083 0.0418
Entamoeba histolytica hypothetical protein 0.0089 0.1021 0.5012
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0045 0.008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.068 0.1362
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.009 0.0159
Echinococcus granulosus jun protein 0.0092 0.1055 0.2129
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0065 0.0051
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0413 0.0726
Echinococcus granulosus Chromo domain 0.0011 0.0045 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0106 0.0092
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0045 0.0139
Plasmodium falciparum glutathione reductase 0.0016 0.0106 0.0313
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1132 0.5579
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.1993 0.1981
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Echinococcus granulosus death domain containing protein 0.0032 0.0309 0.0602
Brugia malayi chromobox protein homolog 3 0.0038 0.0383 0.0674
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.002 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.068 0.0666
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0047 0.0032
Trypanosoma brucei unspecified product 0.0019 0.0143 0.0446
Schistosoma mansoni hypothetical protein 0.0011 0.0047 0.0082
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.1993 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0424 0.19
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Schistosoma mansoni hypothetical protein 0.0037 0.0365 0.0643
Toxoplasma gondii propionate-CoA ligase 0.0015 0.009 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.068 0.1197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.1357 0.2388
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0157 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.1993 0.6267
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 0.0896
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0309 0.0543
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0095 0.025
Loa Loa (eye worm) hypothetical protein 0.005 0.0533 0.0918
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0365 0.0717
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.1021 0.5012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0095 0.0167
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0898 0.158
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0271 0.0525
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0315 0.0615
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1658 0.1645
Schistosoma mansoni hypothetical protein 0.0075 0.084 0.1478
Trypanosoma brucei trypanothione reductase 0.0046 0.0484 0.2207
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0069 0.0212
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0533 0.2677
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0143 0.0432
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Echinococcus multilocularis kelch ECH associated protein 1 0.0106 0.1229 0.1216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0103 0.0158
Trypanosoma brucei unspecified product 0.0013 0.0069 0.0067
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0106 0.0533
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0497 0.0875
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0271 0.0257
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0218 0.1093
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4902 0.4895
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1034 0.1801
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.068 0.1197
Onchocerca volvulus 0.0038 0.0381 0.1699
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.2189 0.4448
Brugia malayi Protein kinase domain containing protein 0.0033 0.0319 0.0561
Plasmodium falciparum glutathione reductase 0.0046 0.0484 0.2251
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0672 0.318
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.1993 0.6117
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0143 0.0446
Mycobacterium tuberculosis Probable reductase 0.0105 0.1224 0.6141
Schistosoma mansoni jun-related protein 0.0075 0.084 0.1478
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1132 0.1992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.068 0.1177
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.009 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Mycobacterium leprae Possible D-ribose-binding protein 0.0262 0.3177 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.1993 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0533
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0017 0.0122 0.0611
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.068 0.1362
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0106 0.0326
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0143 0.0438
Brugia malayi Smad1 0.0009 0.002 0.0035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0419 0.1891
Echinococcus granulosus ETS domain containing protein Elk 1 0.0022 0.0182 0.0343
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.1034 0.182
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0095 0.0291
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.002 0.0012
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0237 0.0723
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0106 0.0258
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.068 0.0666
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0045 0.0139
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0375 0.1145
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.1357 0.237
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0218 0.0833
Echinococcus granulosus nuclear factor of activated T cells 5 0.0165 0.1968 0.3997
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0413 0.1267
Loa Loa (eye worm) hypothetical protein 0.0038 0.0383 0.0653
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0106 0.0533
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.1993 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0424 0.1946
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Loa Loa (eye worm) hypothetical protein 0.0089 0.1024 0.1783
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0349 0.1753
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0419 0.1287
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0413 0.1886
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0533 0.2677
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0375 0.1881
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0851 0.1712
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0103 0.0295
Schistosoma mansoni hypothetical protein 0.0037 0.0365 0.0643
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0271 0.0477
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0372 0.1867
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0237 0.119
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0424 0.19
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1224 0.6141
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0103 0.0295
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1371 0.6878
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.009 0.0453
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Echinococcus granulosus smad 0.0009 0.002 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0432 0.0854
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0262 0.3177 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1224 0.6141
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.009 0.0175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0571 0.2698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0088
Echinococcus granulosus cpg binding protein 0.003 0.0277 0.0537
Echinococcus multilocularis chromobox protein 1 0.0068 0.0757 0.0744
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.009 0.0453
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0143 0.0716
Brugia malayi MH1 domain containing protein 0.0009 0.002 0.0035
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0157 0.0476
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0045 0.0139
Echinococcus multilocularis Chromo domain 0.0011 0.0045 0.0031
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0271 0.0455
Echinococcus granulosus chromobox protein 1 0.0068 0.0757 0.1519
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0271 0.1142
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0484 0.2427
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1034 0.182
Giardia lamblia Phosphoglycerate kinase 0.0167 0.1993 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0143 0.0229
Schistosoma mansoni tsg101-related 0.0065 0.0717 0.1263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0638
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0638
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1471 0.1459
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.013 0.0652
Echinococcus granulosus kelch ECH associated protein 1 0.0106 0.1229 0.2485
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.009 0.0277
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0533 0.2506
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0419 0.1287
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0309 0.0543
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0672 0.318
Schistosoma mansoni tsg101-related 0.0065 0.0717 0.1263
Brugia malayi CXXC zinc finger family protein 0.0028 0.0257 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0069 0.0066
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0533 0.1668
Brugia malayi conserved hypotetical protein 0.0029 0.0271 0.0477
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.009 0.0453
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.078
Echinococcus granulosus dnaJ subfamily B 0.04 0.4902 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0413 0.1267
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0089 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0381 0.065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.068 0.1177
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0106 0.0258
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0271 0.0477
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0484 0.047
Brugia malayi ecdysone receptor 0.0029 0.0271 0.0477
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0053 0.0093
Schistosoma mansoni hypothetical protein 0.0041 0.0413 0.0727
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0271 0.0477
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0349 0.1753
Echinococcus multilocularis ETS transcription factor Elf 2 0.0022 0.0182 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0069 0.0067
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0292 0.1216
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.1993 1
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0262 0.3177 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0638
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.068 0.1197
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0125 0.0383
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0103 0.024
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1132 0.1119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.1055 0.1042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.068 0.1197
Brugia malayi isocitrate dehydrogenase 0.0016 0.0103 0.0181
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0424 0.0838
Leishmania major hypothetical protein, conserved 0.0025 0.0218 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.068 0.1197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.068 0.0666
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.068 0.1362
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Echinococcus granulosus dual specificity 0.0089 0.1021 0.206
Brugia malayi hypothetical protein 0.0011 0.0049 0.0086
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0108 0.0323
Brugia malayi Phosphoglycerate kinase 0.0167 0.1993 0.3507
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.1235 0.6111
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1471 0.2572
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0017 0.0122 0.0611
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0157 0.0476
Brugia malayi MH2 domain containing protein 0.0134 0.1579 0.2779
Echinococcus granulosus kelch ECH associated protein 1 like 0.0106 0.1229 0.2485
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.009 0.0277
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0106 0.0533
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0065 0.0325
Brugia malayi Heterochromatin protein 1 0.0068 0.0757 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.068 0.1197
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.1993 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0432 0.0418
Loa Loa (eye worm) RNA binding protein 0.0125 0.1471 0.2572
Brugia malayi nuclear receptor NHR-88 0.0029 0.0271 0.0477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0533 0.2677
Schistosoma mansoni cpg binding protein 0.0028 0.0257 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.068 0.1197
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0424 0.2129
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Mycobacterium ulcerans polyketide synthase 0.0026 0.0237 0.0723
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0672 0.318
Loa Loa (eye worm) hypothetical protein 0.0098 0.1132 0.1973
Brugia malayi AMP-binding enzyme family protein 0.0015 0.009 0.0159
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0424 0.0747
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0218 0.1093
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0047 0.0066
Echinococcus granulosus Ankyrin 0.0032 0.0312 0.0609
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.002 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.068 0.1362
Schistosoma mansoni Smad4 0.0009 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0119
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0088 0.027
Onchocerca volvulus 0.003 0.028 0.1187
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0779
Loa Loa (eye worm) hypothetical protein 0.0167 0.1993 0.3492
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0065 0.0115
Brugia malayi MH1 domain containing protein 0.0009 0.002 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0143 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0271 0.0477
Brugia malayi bZIP transcription factor family protein 0.0092 0.1055 0.1857
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0082 0.0252
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0106 0.032
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2189 0.2177
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0017 0.0122 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Schistosoma mansoni tyrosinase precursor 0.009 0.1034 0.182
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0218 0.0663
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0103 0.0295
Loa Loa (eye worm) tyrosinase 1 0.009 0.1034 0.1801
Brugia malayi nuclear hormone receptor 0.0062 0.068 0.1197
Leishmania major DNA polymerase eta, putative 0.0044 0.0455 0.2283
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0056 0.0076
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0045 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.068 0.0666
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1034 0.1801
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0143 0.0262
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0271 0.0477
Trypanosoma brucei glucosidase, putative 0.0041 0.0413 0.184
Echinococcus granulosus GPCR family 2 0.0037 0.0365 0.0717
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0128 0.0424
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0078 0.088 0.1771
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0045 0.0139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0237 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Schistosoma mansoni coup transcription factor 0.0062 0.068 0.1197
Onchocerca volvulus 0.0029 0.0271 0.1142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0298
Onchocerca volvulus 0.005 0.0533 0.2467
Schistosoma mansoni ets-related 0.0462 0.5682 1
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0455 0.0801
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0022 0.0182 0.032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.068 0.1197
Brugia malayi Protein cec-1. 0.0011 0.0045 0.008
Schistosoma mansoni smad1 5 8 and 0.0009 0.002 0.0035
Loa Loa (eye worm) fli-1 protein 0.0462 0.5682 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0271 0.1142
Brugia malayi Phosphoglycerate kinase 0.0061 0.0672 0.1183
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.1993 0.3507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0045 0.008
Brugia malayi Death domain containing protein 0.0032 0.0309 0.0543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.009 0.0453
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0365
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.068 0.1197
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.002 0.0011
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0432 0.0854
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0565 0.2668
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.068 0.1197
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0004 0.0006
Schistosoma mansoni cpg binding protein 0.003 0.0277 0.0487
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0017 0.0122 0.0368
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0112 0.0339
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1224 0.6141
Brugia malayi nuclear hormone receptor 0.0029 0.0271 0.0477
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.1021 0.5126
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0244 0.0749
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0065 0.0092
Echinococcus granulosus Smad4 0.0009 0.002 0.0011
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0062 0.068 0.1197
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0424 0.041
Entamoeba histolytica hypothetical protein 0.0076 0.0851 0.4138
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0413 0.1267
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0533 0.1633
Onchocerca volvulus 0.0029 0.0271 0.1142
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0365 0.0621
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.1235 0.1222
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0672 0.318
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0045 0.008
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.009 0.0159
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0851 0.0838
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.068 0.1197
Loa Loa (eye worm) Smad1 0.0009 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0169 0.2023 0.3546
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0271 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0567 0.1741
Brugia malayi Uncoordinated protein 44 0.0032 0.0309 0.0543
Brugia malayi MH2 domain containing protein 0.0009 0.002 0.0035
Entamoeba histolytica hypothetical protein 0.0013 0.0069 0.0122
Schistosoma mansoni smad 0.0009 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0088 0.1011 0.1761
Mycobacterium ulcerans thioesterase 0.0021 0.0166 0.0503
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0349 0.1753
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0484 0.096
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.022 0.0896
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.1993 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Schistosoma mansoni tyrosinase precursor 0.009 0.1034 0.182
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0237 0.119
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0375 0.1692
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0106 0.0313
Loa Loa (eye worm) hypothetical protein 0.0052 0.055 0.0948
Schistosoma mansoni hypothetical protein 0.04 0.4902 0.8628
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0413 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Loa Loa (eye worm) glutathione reductase 0.0046 0.0484 0.083
Echinococcus multilocularis ETS transcription factor Elf 5 0.0022 0.0182 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1471 0.2589
Schistosoma mansoni alpha glucosidase 0.0041 0.0413 0.0726
Echinococcus multilocularis ewsr:fli fusion protein type 0.0022 0.0182 0.0168
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.009 0.0175
Echinococcus multilocularis protein C ets 2 0.0022 0.0182 0.0168
Loa Loa (eye worm) DR-78 0.0029 0.0271 0.0455
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.068 0.1362
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0413 0.0399
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.068 0.1177
Loa Loa (eye worm) hypothetical protein 0.013 0.1533 0.268
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0103 0.0181
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0045 0.008
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0165 0.1968 0.1956
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0533
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0106 0.032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0424 0.041
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0424 0.2129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0533
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.068 0.1197
Echinococcus multilocularis dual specificity 0.0089 0.1021 0.1008
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0045 0.0031
Echinococcus granulosus ETS transcription factor Elf 1 0.0022 0.0182 0.0343
Plasmodium vivax glutathione reductase, putative 0.0046 0.0484 0.2251
Brugia malayi AMP-binding enzyme family protein 0.005 0.0533 0.0939
Echinococcus granulosus protein C ets 2 0.0022 0.0182 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Leishmania major DNA polymerase kappa, putative 0.0019 0.0143 0.0716
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0038 0.0381 0.1915
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0271 0.0257
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.009 0.0453
Loa Loa (eye worm) glutaminase 0.0268 0.3257 0.5723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0088
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.068 0.0666
Entamoeba histolytica hypothetical protein 0.0076 0.0851 0.4138
Loa Loa (eye worm) hypothetical protein 0.0079 0.0898 0.1561
Echinococcus granulosus chromobox protein 1 0.0068 0.0757 0.1519
Toxoplasma gondii thioredoxin reductase 0.0046 0.0484 0.2251
Echinococcus multilocularis dna polymerase eta 0.0044 0.0455 0.0441
Echinococcus multilocularis ets variant gene 4 0.0022 0.0182 0.0168
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.068 0.0666
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1579 0.2762
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0413 0.1267
Onchocerca volvulus 0.009 0.1034 0.4999
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.009 0.0271
Echinococcus granulosus dna polymerase kappa 0.0019 0.0143 0.0262
Echinococcus multilocularis ETS transcription factor Elf 2 0.0022 0.0182 0.0168
Schistosoma mansoni hypothetical protein 0.0011 0.0045 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0143 0.0446
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0468 0.2137
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0069 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0533 0.1633
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1224 0.6141
Onchocerca volvulus 0.0062 0.068 0.3209
Schistosoma mansoni glutaminase 0.0268 0.3257 0.5733
Echinococcus granulosus expressed conserved protein 0.0092 0.1057 0.2133
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0095 0.0291
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0309 0.0521
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0271 0.0257
Leishmania major trypanothione reductase 0.0046 0.0484 0.2427
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.009 0.0231
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.002 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.022 0.0845
Brugia malayi ecdysteroid receptor 0.0062 0.068 0.1197
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0237 0.0735
Entamoeba histolytica hypothetical protein 0.0013 0.0069 0.0122
Plasmodium falciparum thioredoxin reductase 0.0016 0.0106 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0424 0.1302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0017 0.0122 0.0611
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.068 0.3209
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0078 0.088 0.0867
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.018
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0106 0.0187
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0106 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0533 0.1633
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0257 0.043
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.2189 0.2177
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0022 0.0182 0.0298
Giardia lamblia DINP protein human, muc B family 0.0019 0.0143 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0757 0.2324
Echinococcus granulosus ETS transcription factor Elf 5 0.0022 0.0182 0.0343
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0095 0.0198
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0757 0.1312
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0237 0.0723
Schistosoma mansoni ets 0.0022 0.0182 0.032
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.1021 0.4984
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0214 0.0354
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0424 0.041
Echinococcus multilocularis Kelch repeat type 1 0.0106 0.1233 0.122
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0095 0.0291
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0143 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0315 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0432 0.1326
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0372 0.116
Echinococcus multilocularis Ankyrin 0.0032 0.0312 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.009 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0271 0.0477
Loa Loa (eye worm) hypothetical protein 0.005 0.0533 0.0918
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0315 0.0301
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0292 0.1266
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0271 0.0477
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0017 0.0122 0.0368
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Brugia malayi AMP-binding enzyme family protein 0.005 0.0533 0.0939
Echinococcus multilocularis ETS transcription factor Elf 1 0.0022 0.0182 0.0168
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0218 0.0663
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0424 0.0838
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0053 0.0569 0.2688
Schistosoma mansoni patched 1 0.0042 0.0432 0.076
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 0.0896
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0218 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0383 0.1176
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0208 0.1045
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0455 0.2059
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.009 0.0175
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.068 0.1197
Mycobacterium ulcerans hypothetical protein 0.005 0.0533 0.1633
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0271 0.0455
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0533
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0045 0.008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0106 0.0258
Echinococcus multilocularis cpg binding protein 0.003 0.0277 0.0263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.1235 0.6199
Loa Loa (eye worm) hypothetical protein 0.0041 0.0424 0.0725
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.009 0.0271
Entamoeba histolytica protein kinase, putative 0.0089 0.1021 0.5012
Echinococcus granulosus ETS transcription factor Elf 2 0.0022 0.0182 0.0343
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0103 0.0516
Schistosoma mansoni hypothetical protein 0.0022 0.0182 0.032
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.009 0.0175
Onchocerca volvulus 0.0072 0.0809 0.3858
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.009 0.0076
Leishmania major DNA polymerase eta, putative 0.0031 0.0292 0.1465
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0484 0.2251
Giardia lamblia Kinase, PLK 0.0106 0.1235 0.6199
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0672 0.318
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.1993 0.6117
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0271 0.0525
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1151 0.2025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0143 0.05
Entamoeba histolytica protein kinase, putative 0.0089 0.1021 0.5012
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0372 0.1137
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0106 0.0313
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0095 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0088 0.027
Schistosoma mansoni hypothetical protein 0.0037 0.0365 0.0643
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Brugia malayi Fli-1 protein 0.0462 0.5682 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0069 0.0067
Schistosoma mansoni hypothetical protein 0.0041 0.0413 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1235 0.3792
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.009 0.0271
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.009 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.1235 0.2156
Treponema pallidum phosphoglycerate kinase 0.0167 0.1993 0.6143
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.1993 0.3507
Leishmania major hypothetical protein, conserved 0.0025 0.022 0.1103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0533 0.1668
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.009 0.0453
Brugia malayi hypothetical protein 0.0033 0.0315 0.0554
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0413 0.1267
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0143 0.0446
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0143 0.0438
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.009 0.0271
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Onchocerca volvulus 0.0021 0.0169 0.0625
Onchocerca volvulus 0.0028 0.0257 0.1069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.068 0.1197
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0166 0.0832
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.065 0.1144
Echinococcus multilocularis chromobox protein 1 0.0068 0.0757 0.0744
Onchocerca volvulus 0.009 0.1034 0.4999
Loa Loa (eye worm) hypothetical protein 0.009 0.1034 0.1801
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0413 0.0814
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0271 0.0257
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0106 0.0326
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0424 0.0747
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.0845
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.009 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0122 0.0368
Brugia malayi TAR-binding protein 0.0125 0.1471 0.2589
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0244 0.0749
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0218 0.0383
Schistosoma mansoni hypothetical protein 0.0041 0.0413 0.0727
Schistosoma mansoni smad1 5 8 and 0.0009 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0638
Brugia malayi Cytochrome P450 family protein 0.0012 0.0056 0.0099
Schistosoma mansoni DNA polymerase eta 0.0044 0.0455 0.0801
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0424 0.0747
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.1993 1
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0166 0.0503
Brugia malayi CHD4 protein 0.0013 0.0065 0.0115
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0106 0.0313
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0218 0.0663
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.1235 0.2498
Mycobacterium ulcerans glutaminase 0.0268 0.3257 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0106 0.1229 0.2485
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0533
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1132 0.2285
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.068 0.1177
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.068 0.1197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.068 0.1177
Onchocerca volvulus 0.0169 0.2023 1
Brugia malayi glutathione reductase 0.0046 0.0484 0.0851
Brugia malayi CHE-14 protein 0.0042 0.0432 0.076
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0095 0.0291
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0095 0.0291
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0.0002 0.001
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0309 0.0602
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0069 0.0066
Echinococcus multilocularis protein dispatched 1 0.0048 0.0506 0.0492
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0106 0.0258
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0315 0.0554
Loa Loa (eye worm) hypothetical protein 0.0032 0.0312 0.0527
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.068 0.0666
Echinococcus multilocularis jun protein 0.0092 0.1055 0.1042
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0106 0.0187
Onchocerca volvulus 0.009 0.1034 0.4999
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0106 0.0258
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1021 0.4984
Brugia malayi hypothetical protein 0.0029 0.0271 0.0477
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0053 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.1021 0.1798
Brugia malayi hypothetical protein 0.0078 0.088 0.155
Brugia malayi Thioredoxin reductase 0.0046 0.0484 0.0851
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0365 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.068 0.1177
Schistosoma mansoni chromobox protein 0.0068 0.0757 0.1333
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0375 0.1692
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0424 0.1302
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0106 0.0533
Schistosoma mansoni hypothetical protein 0.0076 0.0851 0.1498
Brugia malayi tailless protein 0.0029 0.0271 0.0477
Loa Loa (eye worm) helicase 0.0011 0.0045 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0533 0.1633
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0122 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.068 0.1197
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0106 0.0187
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0424 0.0838
Brugia malayi hypothetical protein 0.0033 0.0315 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.068 0.1197
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0383 0.1176
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0106 0.0313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0125 0.0383
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0095 0.0476
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.068 0.1197
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.0516
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0095 0.0291
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.022 0.0896
Loa Loa (eye worm) oxidoreductase 0.0015 0.009 0.0136
Brugia malayi Cytochrome P450 family protein 0.0012 0.0056 0.0099
Schistosoma mansoni hypothetical protein 0.0106 0.1233 0.217
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0103 0.024
Schistosoma mansoni chromobox protein 0.0011 0.0045 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0056 0.0076
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0309 0.0294
Loa Loa (eye worm) hypothetical protein 0.0062 0.068 0.1177
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0013 0.0023
Brugia malayi AMP-binding enzyme family protein 0.005 0.0533 0.0939
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.1993 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0672 0.318
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.009 0.0272
Loa Loa (eye worm) hypothetical protein 0.0042 0.0432 0.0739
Echinococcus multilocularis GPCR, family 2 0.0037 0.0365 0.0351
Brugia malayi DNA-binding protein D-ETS-3 0.0022 0.0182 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0045 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0271 0.0525
Trichomonas vaginalis hypothetical protein 0.0011 0.0045 0.0139
Echinococcus granulosus dna polymerase eta 0.0044 0.0455 0.0901
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.0845
Brugia malayi Protein kinase domain containing protein 0.0089 0.1021 0.1798
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0143 0.0446
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0095 0.0291
Echinococcus multilocularis chromobox protein 2 0.0011 0.0045 0.0031
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0372 0.1867
Plasmodium falciparum thioredoxin reductase 0.0046 0.0484 0.2251
Schistosoma mansoni ets-related 0.0022 0.0182 0.032
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.009 0.0272
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.1993 0.4047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0349 0.1753
Echinococcus granulosus ewsr:fli fusion protein type 0.0022 0.0182 0.0343
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0455
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0271 0.0455
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0106 0.032
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0032 0.0161
Brugia malayi hypothetical protein 0.0016 0.0109 0.0191

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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