Detailed information for compound 1598493

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 504.021 | Formula: C32H26ClN3O
  • H donors: 0 H acceptors: 1 LogP: 6.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc2c(c1)C(=N[C@@H](C(=O)N2C)Cc1cn(c2c1cccc2)Cc1ccccc1)c1ccccc1
  • InChi: 1S/C32H26ClN3O/c1-35-29-17-16-25(33)19-27(29)31(23-12-6-3-7-13-23)34-28(32(35)37)18-24-21-36(20-22-10-4-2-5-11-22)30-15-9-8-14-26(24)30/h2-17,19,21,28H,18,20H2,1H3/t28-/m1/s1
  • InChiKey: LPEQPASJAXUBKT-MUUNZHRXSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0171 0.4063 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0171 0.4063 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0171 0.4063 0.5237
Schistosoma mansoni carbonyl reductase 0.0171 0.4063 0.7751
Mycobacterium ulcerans ketoacyl reductase 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0171 0.4063 0.5237
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0171 0.4063 0.3122
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0171 0.4063 0.5
Brugia malayi hypothetical protein 0.0171 0.4063 0.3122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0171 0.4063 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0171 0.4063 0.5237
Loa Loa (eye worm) dehydrogenase 0.0171 0.4063 0.4063
Onchocerca volvulus 0.0171 0.4063 0.5
Loa Loa (eye worm) integrin beta-2 0.0303 1 1
Mycobacterium ulcerans oxidoreductase 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Leishmania major short chain dehydrogenase, putative 0.0171 0.4063 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0171 0.4063 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0171 0.4063 0.5
Entamoeba histolytica hypothetical protein 0.0171 0.4063 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0171 0.4063 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0171 0.4063 0.5
Leishmania major oxidoreductase-like protein 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Trypanosoma cruzi short chain dehydrogenase, putative 0.0171 0.4063 0.5
Brugia malayi Retinol dehydrogenase 12 0.0171 0.4063 0.3122
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0171 0.4063 0.3122
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0171 0.4063 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Echinococcus granulosus hypothetical protein 0.0171 0.4063 0.5237
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0171 0.4063 0.5237
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0171 0.4063 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0171 0.4063 0.3122
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0171 0.4063 0.5237
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0171 0.4063 0.5
Schistosoma mansoni integrin beta subunit 0.0178 0.4373 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0171 0.4063 0.7751
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Leishmania major pteridine reductase 1 0.0171 0.4063 0.5
Mycobacterium leprae Probable oxidoreductase 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0171 0.4063 0.5
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.6614 0.6614
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Echinococcus multilocularis retinol dehydrogenase 11 0.0171 0.4063 0.5237
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Entamoeba histolytica hypothetical protein, conserved 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Trypanosoma brucei short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Giardia lamblia Reductase, putative 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Echinococcus granulosus carbonyl reductase 1 0.0171 0.4063 0.5237
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0171 0.4063 0.5
Brugia malayi hypothetical protein 0.0171 0.4063 0.3122
Trypanosoma brucei short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0171 0.4063 0.5237
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Loa Loa (eye worm) hypothetical protein 0.0116 0.156 0.156
Echinococcus multilocularis conserved hypothetical protein 0.0171 0.4063 0.5237
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0171 0.4063 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Plasmodium vivax hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0171 0.4063 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Onchocerca volvulus 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Echinococcus granulosus carbonyl reductase 1 0.0171 0.4063 0.5237
Toxoplasma gondii oxidoreductase, putative 0.0171 0.4063 0.5
Leishmania major short chain dehydrogenase, putative 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Leishmania major dehydrogenase-like protein 0.0171 0.4063 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0171 0.4063 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0171 0.4063 0.5237
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0171 0.4063 0.7751
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Echinococcus multilocularis transient receptor potential cation channel 0.0171 0.4063 0.5237
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0171 0.4063 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0171 0.4063 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0171 0.4063 0.5
Leishmania major hypothetical protein, conserved 0.0171 0.4063 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Onchocerca volvulus 0.0171 0.4063 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.1368 0.1368
Mycobacterium ulcerans dehydrogenase 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Brugia malayi oxidoreductase 0.0171 0.4063 0.3122
Echinococcus multilocularis carbonyl reductase 1 0.0171 0.4063 0.5237
Leishmania major short chain dehydrogenase/reductase, putative 0.0171 0.4063 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0171 0.4063 0.5
Echinococcus granulosus integrin beta 2 0.0224 0.6452 1
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0171 0.4063 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Echinococcus granulosus carbonyl reductase 1 0.0171 0.4063 0.5237
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0171 0.4063 0.7751
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0171 0.4063 0.5
Leishmania major hypothetical protein, conserved 0.0171 0.4063 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0171 0.4063 0.5237
Onchocerca volvulus 0.0171 0.4063 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0171 0.4063 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0171 0.4063 0.5237
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0171 0.4063 0.5237
Mycobacterium ulcerans ketoacyl reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Echinococcus multilocularis retinol dehydrogenase 13 0.0171 0.4063 0.5237
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Mycobacterium ulcerans dehydrogenase/reductase 0.0171 0.4063 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Mycobacterium ulcerans short-chain dehydrogenase 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0171 0.4063 0.5237
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0171 0.4063 0.5
Schistosoma mansoni retinal dehydrogenase 0.0171 0.4063 0.7751
Mycobacterium tuberculosis Possible oxidoreductase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0171 0.4063 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0171 0.4063 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0171 0.4063 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0171 0.4063 0.5
Echinococcus granulosus hypothetical protein 0.0171 0.4063 0.5237
Schistosoma mansoni carbonyl reductase 0.0171 0.4063 0.7751
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Onchocerca volvulus Sepiapterin reductase homolog 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Giardia lamblia Short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Giardia lamblia Hypothetical protein 0.0171 0.4063 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Toxoplasma gondii oxidoreductase, putative 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 0.4063 0.4063
Echinococcus granulosus steroid dehydrogenase 0.0171 0.4063 0.5237
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0171 0.4063 0.5237
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Mycobacterium tuberculosis Probable dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0171 0.4063 0.5237
Leishmania major short chain dehydrogenase-like protein 0.0171 0.4063 0.5
Echinococcus granulosus oxidoreductase 0.0171 0.4063 0.5237
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0171 0.4063 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0171 0.4063 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) dehydrogenase 0.0171 0.4063 0.4063
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Echinococcus multilocularis carbonyl reductase 1 0.0171 0.4063 0.5237
Echinococcus multilocularis oxidoreductase 0.0171 0.4063 0.5237
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0171 0.4063 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0171 0.4063 0.5237
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0171 0.4063 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0171 0.4063 0.7751
Onchocerca volvulus 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0171 0.4063 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Onchocerca volvulus 0.0171 0.4063 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium ulcerans short-chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0171 0.4063 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0171 0.4063 0.3122
Trypanosoma cruzi short chain dehydrogenase, putative 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Mycobacterium ulcerans short-chain dehydrogenase 0.0171 0.4063 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0171 0.4063 0.5
Onchocerca volvulus 0.0171 0.4063 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Echinococcus granulosus carbonyl reductase 1 0.0171 0.4063 0.5237
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0171 0.4063 0.5237
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0171 0.4063 0.5
Leishmania major hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0171 0.4063 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0171 0.4063 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0171 0.4063 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0171 0.4063 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0171 0.4063 0.5237
Echinococcus multilocularis integrin beta 2 0.0224 0.6452 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0171 0.4063 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0171 0.4063 0.5
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.2996 0.1886
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Brugia malayi Dehydrogenases, short chain protein 30 0.0171 0.4063 0.3122
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0171 0.4063 0.5237
Brugia malayi dehydrogenases, short chain protein 9 0.0171 0.4063 0.3122
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0171 0.4063 0.5
Leishmania major hypothetical protein, conserved 0.0171 0.4063 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0171 0.4063 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0171 0.4063 0.3122
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Mycobacterium ulcerans oxidoreductase 0.0171 0.4063 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0171 0.4063 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0171 0.4063 0.5
Schistosoma mansoni carbonyl reductase 0.0171 0.4063 0.7751
Schistosoma mansoni steroid dehydrogenase 0.0171 0.4063 0.7751
Schistosoma mansoni short chain dehydrogenase 0.0171 0.4063 0.7751
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0171 0.4063 0.3122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0171 0.4063 0.5
Loa Loa (eye worm) oxidoreductase 0.0171 0.4063 0.4063
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.4063 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0171 0.4063 0.4063
Leishmania major hypothetical protein, conserved 0.0171 0.4063 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0171 0.4063 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Half-maximal inhibition of [125I]-CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptor ChEMBL. 2885419
IC50 (functional) > 100 uM Half-maximal inhibition of binding of [125I]-gastrin to guinea pig gastric glands ChEMBL. 2885419
IC50 (binding) ~ 150 uM Half-maximal inhibition of [125I]-CCK-33 binding to rat pancreas cholecystokinin receptor ChEMBL. 2885419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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