Detailed information for compound 160496

Basic information

Technical information
  • TDR Targets ID: 160496
  • Name: sodium (2S)-1-[(2S)-3-[[(1R)-1-benzamido-2-ph enylethyl]-dihydroxysilyl]-2-methylpropanoyl] pyrrolidine-2-carboxylate
  • MW: 492.572 | Formula: C24H29N2NaO6Si
  • H donors: 3 H acceptors: 6 LogP: 3.4 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)N1CCC[C@H]1C(=O)[O-])C[Si]([C@@H](NC(=O)c1ccccc1)Cc1ccccc1)(O)O.[Na+]
  • InChi: 1S/C24H30N2O6Si.Na/c1-17(23(28)26-14-8-13-20(26)24(29)30)16-33(31,32)21(15-18-9-4-2-5-10-18)25-22(27)19-11-6-3-7-12-19;/h2-7,9-12,17,20-21,31-32H,8,13-16H2,1H3,(H,25,27)(H,29,30);/q;+1/p-1/t17-,20+,21-;/m1./s1
  • InChiKey: QXXOXGZEMXKCHV-NIFMGCQOSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • sodium (2S)-1-[(2S)-3-[[(1R)-1-benzamido-2-phenyl-ethyl]-dihydroxy-silyl]-2-methyl-propanoyl]pyrrolidine-2-carboxylate
  • sodium (2S)-1-[(2S)-3-[[(1R)-1-benzamido-2-phenylethyl]-dihydroxysilyl]-2-methyl-1-oxopropyl]-2-pyrrolidinecarboxylate
  • sodium (2S)-1-[(2S)-3-[[(1R)-1-(benzoylamino)-2-phenylethyl]-dihydroxysilyl]-2-methylpropanoyl]pyrrolidine-2-carboxylate
  • sodium (2S)-1-[(2S)-3-[[(1R)-1-(benzoylamino)-2-phenyl-ethyl]-dihydroxy-silyl]-2-methyl-propanoyl]pyrrolidine-2-carboxylate
  • sodium (2S)-1-[(2S)-3-[dihydroxy-[(1R)-1-[(oxo-phenylmethyl)amino]-2-phenylethyl]silyl]-2-methyl-1-oxopropyl]-2-pyrrolidinecarboxylate
  • sodium (2S)-1-[(2S)-3-[dihydroxy-[(1R)-2-phenyl-1-(phenylcarbonylamino)ethyl]silyl]-2-methyl-propanoyl]pyrrolidine-2-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Angiotensin-converting enzyme Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0687 0.0687
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0426 0.4746
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0016 0.0058 0.0127
Brugia malayi hypothetical protein 0.0019 0.0091 0.0091
Leishmania major cathepsin L-like protease 0.0161 0.2019 1
Brugia malayi hypothetical protein 0.0071 0.08 0.08
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0016 0.0058 0.0127
Schistosoma mansoni zinc finger protein 0.0029 0.0239 0.064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Schistosoma mansoni protein arginine n-methyltransferase 0.0016 0.005 0.0135
Brugia malayi Cathepsin L-like precursor 0.0028 0.0222 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0687 0.0687
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0346 0.0927
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0042 0.0411 0.0411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0687 0.1492
Schistosoma mansoni SWI/SNF complex-related 0.0018 0.0084 0.0224
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0071 0.08 0.3951
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0012 0.0004 0.0035
Onchocerca volvulus 0.0231 0.2973 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0222 0.0222
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0091 0.1074 0.5311
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0426 0.0926
Loa Loa (eye worm) hypothetical protein 0.0061 0.0671 0.0671
Schistosoma mansoni chromobox protein 0.0072 0.0822 0.2198
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0012 0.0004 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.003 0.0471
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0346 0.0753
Brugia malayi tailless protein 0.0029 0.0239 0.0239
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0411 0.0893
Brugia malayi nuclear receptor NHR-88 0.0029 0.0239 0.0239
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0025 0.0174 0.374
Loa Loa (eye worm) hypothetical protein 0.0043 0.0426 0.0426
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0012 0.0004 0.001
Echinococcus granulosus protein arginine N methyltransferase 7 0.0016 0.005 0.0109
Echinococcus granulosus protein arginine N methyltransferase 8 0.0055 0.0589 0.1279
Schistosoma mansoni hypothetical protein 0.0225 0.289 0.7732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Echinococcus granulosus cathepsin L cysteine proteinase 0.0042 0.0411 0.0894
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0411 0.1383
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0426 0.2097
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0012 0.0004 0.001
Echinococcus multilocularis cathepsin L 0.0022 0.0134 0.0291
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0214 0.0464
Brugia malayi Protein arginine N-methyltransferase 0.0016 0.005 0.005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.0411 0.0411
Brugia malayi hypothetical protein 0.0037 0.0346 0.0346
Loa Loa (eye worm) fibroinase 0.0042 0.0411 0.0411
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0134 0.0358
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 0.3738 0.812
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.2494 0.8389
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0426 0.4746
Loa Loa (eye worm) hypothetical protein 0.0231 0.2973 0.2973
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0239 0.0519
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0287
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0016 0.005 0.0109
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0432 0.1452
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0135 0.0293
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0058 0.0156
Leishmania major cathepsin L-like protease 0.0042 0.0411 0.2022
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0012 0.0004 0.001
Trichomonas vaginalis adenylate cyclase, putative 0.0019 0.0091 0.0847
Echinococcus multilocularis lipoxygenase domain containing protein 0.0078 0.0898 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Schistosoma mansoni DNA helicase recq1 0.0015 0.004 0.0107
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0687 0.1492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0687 0.1492
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0687 0.0687
Brugia malayi hypothetical protein 0.0043 0.0426 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.1074 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Brugia malayi Doublecortin family protein 0.0078 0.0898 0.0898
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0016 0.005 0.0231
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0688 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0687 0.0687
Leishmania major cysteine peptidase A (CPA) 0.0042 0.0411 0.2022
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0426 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0046 0.046 0.046
Brugia malayi Cathepsin L-like precursor 0.0028 0.0222 0.0222
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0337 0.0901
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0411 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0134 0.1247
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0048 0.0495 0.6188
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0012 0.0004 0.0008
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0016 0.005 0.0231
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0687 0.1838
Schistosoma mansoni apoptosis regulator bax 0.0264 0.3424 0.916
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0239 0.0519
Echinococcus multilocularis transfer RNA-Lys 0.0053 0.0556 0.1208
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0004 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0687 0.1492
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0687 0.1492
Echinococcus multilocularis lipoxygenase domain containing protein 0.0078 0.0898 0.1952
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Onchocerca volvulus 0.0051 0.0537 0.1805
Plasmodium vivax vivapain-2 0.0042 0.0411 0.4579
Onchocerca volvulus 0.0042 0.0411 0.1383
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0016 0.005 0.0231
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0426 0.9269
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.000000000082814 0.00000000077107
Leishmania major protein kinase, putative 0.0031 0.0267 0.1305
Leishmania major cathepsin L-like protease 0.0042 0.0411 0.2022
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0012 0.0004 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0687 0.1838
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0239 0.064
Onchocerca volvulus 0.0029 0.0239 0.0804
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0055 0.0589 0.6555
Echinococcus granulosus mitogen activated protein kinase 0.0091 0.1074 0.2333
Echinococcus multilocularis chromobox protein 1 0.0072 0.0822 0.1785
Onchocerca volvulus 0.0078 0.0898 0.3022
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0213 0.2729 0.73
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0687 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.0847
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0134 0.1674
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0058 0.0544
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0239 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0687 0.0687
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0239 0.0519
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0287 0.0768
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0015 0.004 0.0446
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0004 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0426 0.397
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0048 0.0495 0.2438
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0048 0.0495 0.0495
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0016 0.005 0.0469
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.001
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.0134 0.0646
Echinococcus multilocularis aryl hydrocarbon receptor 0.0154 0.1932 0.4196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Onchocerca volvulus 0.0032 0.0271 0.0911
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0687 0.1492
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0055 0.0589 0.1576
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0016 0.005 0.0231
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0012 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0058
Echinococcus multilocularis bloom syndrome protein 0.0015 0.004 0.0087
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0135 0.036
Loa Loa (eye worm) hypothetical protein 0.0078 0.0898 0.0898
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.0000000010351
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0779
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0015 0.004 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Brugia malayi nuclear hormone receptor 0.0062 0.0687 0.0687
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0411 0.0894
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0687 0.1492
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.003 0.0065
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0222 0.0594
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Onchocerca volvulus 0.0154 0.1923 0.6469
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0687 0.0687
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0214 0.3797
Brugia malayi jmjC domain containing protein 0.0099 0.1186 0.1186
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0012 0.0004 0.001
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0015 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0687 0.1838
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Brugia malayi Carm1-pending protein 0.0016 0.005 0.005
Echinococcus granulosus Chromo domain 0.0012 0.000000000082814 0.0000000001799
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0264 0.3424 0.7438
Schistosoma mansoni aryl hydrocarbon receptor 0.0207 0.2649 0.7086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0687 0.0687
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0046 0.046 0.123
Leishmania major cathepsin L-like protease 0.0161 0.2019 1
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0016 0.005 0.0629
Echinococcus multilocularis geminin 0.0154 0.1935 0.4205
Brugia malayi nuclear receptor RXR 0.0029 0.0239 0.0239
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0426 0.397
Schistosoma mansoni amine oxidase 0.0043 0.0426 0.1141
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.003 0.0332
Leishmania major cathepsin L-like protease 0.0042 0.0411 0.2022
Trypanosoma brucei protein kinase, putative 0.0091 0.1074 0.5311
Brugia malayi nuclear hormone receptor 0.0029 0.0239 0.0239
Giardia lamblia Sgs1 DNA helicase, putative 0.0015 0.004 0.0339
Schistosoma mansoni ap endonuclease 0.0014 0.003 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0229 0.2133
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0687 0.1838
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.000000000082814 0.000000000082814
Brugia malayi small heat shock protein 0.0523 0.6937 0.6937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0028 0.0222 0.0222
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0065 0.0724 0.0724
Brugia malayi Cyclic-nucleotide gated cation channel 0.0016 0.0058 0.0058
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.003 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0222 0.2777
Mycobacterium ulcerans dehydrogenase 0.0043 0.0426 0.765
Entamoeba histolytica SWIRM domain protein 0.0018 0.0084 0.1046
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.004
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Plasmodium vivax vivapain-2 0.0042 0.0411 0.4579
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.000000000082814 0.0000000001799
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0015 0.004 0.0087
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0012 0.0004 0.0008
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Plasmodium falciparum cGMP-dependent protein kinase 0.0013 0.0015 0.0167
Onchocerca volvulus 0.0028 0.0222 0.0747
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.025 0.0544
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0426 0.4746
Echinococcus granulosus cathepsin L 0.0022 0.0134 0.0291
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0426 0.4746
Echinococcus multilocularis Chromo domain 0.0012 0.000000000082814 0.0000000001799
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0239 0.0519
Trypanosoma cruzi cysteine protease, putative 0.0022 0.0134 0.0646
Brugia malayi nuclear receptor NHR-67 0.0029 0.0239 0.0239
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0687 0.2311
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Brugia malayi SWIRM domain containing protein 0.0231 0.2973 0.2973
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0071 0.08 1
Echinococcus multilocularis cysteine protease 0.0042 0.0411 0.0894
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.1074 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Brugia malayi conserved hypotetical protein 0.0029 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0052 0.0544 0.0544
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0822 0.7649
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0048 0.0495 0.0495
Plasmodium vivax unspecified product 0.0022 0.0134 0.1491
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0048 0.0495 0.1324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0287 0.0287
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0004 0.001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0058 0.0544
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0426 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Schistosoma mansoni hypothetical protein 0.0264 0.3424 0.916
Echinococcus granulosus cathepsin L cysteine protease 0.0022 0.0134 0.0291
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0012 0.0004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Giardia lamblia hypothetical protein 0.0018 0.0084 0.0746
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0219 0.2805 0.6093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.003 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Toxoplasma gondii exonuclease III APE 0.0014 0.003 0.0278
Mycobacterium ulcerans putative regulatory protein 0.0053 0.0556 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0239 0.0519
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0687 0.1838
Loa Loa (eye worm) hypothetical protein 0.0022 0.0135 0.0135
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0102 0.0488
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0135 0.1671 0.1671
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0014 0.0028 0.0028
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0019 0.0099 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0134 0.0134
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0012 0.0004 0.0035
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0012 0.0004 0.0008
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.0058 0.0127
Echinococcus multilocularis mitogen activated protein kinase 3 0.0091 0.1074 0.2333
Plasmodium falciparum cysteine proteinase falcipain 1 0.0022 0.0134 0.1491
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.003 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.000000000082814 0.000000000082814
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0048 0.0495 0.1075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0084
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0016 0.005 0.0469
Loa Loa (eye worm) DR-78 0.0029 0.0239 0.0239
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0337 0.0732
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0687 0.1838
Leishmania major protein kinase, putative 0.0013 0.0015 0.0055
Onchocerca volvulus 0.0012 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Plasmodium falciparum cysteine proteinase falcipain 3 0.0042 0.0411 0.4579
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0426 0.765
Brugia malayi Cathepsin L-like precursor 0.0014 0.0028 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0687 0.0687
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0091 0.0433
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0134 0.0646
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0058 0.0156
Schistosoma mansoni loxhd1 0.0078 0.0898 0.2404
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0016 0.005 0.0231
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0225 0.289 0.6278
Onchocerca volvulus 0.0042 0.0411 0.1383
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0135 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0051 0.0537 0.0537
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0015 0.004 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.004
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0016 0.005 0.0469
Schistosoma mansoni cathepsin s 0.0014 0.0028 0.0076
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0019 0.0091 0.0847
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.0801 0.2142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.003 0.0129
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0239 0.0804
Loa Loa (eye worm) hypothetical protein 0.0154 0.1923 0.1923
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0411 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0222 0.2069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0264 0.3424 0.3424
Schistosoma mansoni lipoxygenase 0.0219 0.2805 0.7504
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0013 0.0015 0.0139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0287 0.0768
Brugia malayi Cathepsin L-like cysteine proteinase 0.0028 0.0222 0.0222
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0091 0.0847
Entamoeba histolytica hypothetical protein 0.0071 0.08 1
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0012 0.0004 0.0004
Entamoeba histolytica SWIRM domain protein 0.0018 0.0084 0.1046
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.004 0.018
Brugia malayi CHD4 protein 0.0012 0.000000000082814 0.000000000082814
Entamoeba histolytica hypothetical protein 0.0012 0.000000000082814 0.0000000010351
Brugia malayi hypothetical protein 0.0033 0.0287 0.0287
Brugia malayi Egg laying defective protein 4 0.0013 0.0015 0.0015
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0264 0.3424 0.916
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0134 0.0358
Brugia malayi steroid hormone receptor 0.0062 0.0687 0.0687
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0426 0.4746
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0687 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0084 0.0779
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0032 0.0271 0.0271
Entamoeba histolytica recQ family helicase, putative 0.0015 0.004 0.0501
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0046 0.046 0.0999
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.003 0.0129
Trypanosoma cruzi cysteine proteinase, putative 0.0022 0.0134 0.0646
Echinococcus multilocularis expressed conserved protein 0.0013 0.0015 0.0033
Schistosoma mansoni single-minded 0.0071 0.0808 0.2162
Trichomonas vaginalis guanylate cyclase, putative 0.0019 0.0091 0.0847
Echinococcus multilocularis peregrin 0.003 0.025 0.0544
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0016 0.0058 0.0127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.003 0.0571
Loa Loa (eye worm) hypothetical protein 0.0523 0.6937 0.6937
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0687 0.1492
Echinococcus granulosus geminin 0.0154 0.1935 0.4205
Echinococcus multilocularis RUN 0.0078 0.0898 0.1952
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0016 0.005 0.0109
Loa Loa (eye worm) ctsf protein 0.0042 0.0411 0.0411
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0055 0.0589 0.5483
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.1074 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0016 0.0058 0.0127
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0239 0.064
Onchocerca volvulus 0.0053 0.0565 0.1899
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0214 0.1041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0048 0.0495 0.2438
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.004 0.018
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0057 0.0618 0.5757
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0015 0.004 0.0087
Schistosoma mansoni hypothetical protein 0.0264 0.3424 0.916
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Loa Loa (eye worm) doublecortin family protein 0.0078 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0078 0.0898 0.0898
Brugia malayi PHD-finger family protein 0.003 0.025 0.025
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0016 0.005 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0046 0.046 0.2262
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0058 0.0156
Entamoeba histolytica hypothetical protein 0.0037 0.0346 0.4331
Echinococcus granulosus mitogen activated protein kinase 3 0.0091 0.1074 0.2333
Echinococcus granulosus cGMP dependent protein kinase 1 0.0013 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.1074 1
Brugia malayi hypothetical protein 0.0029 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0053 0.056 0.056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0012 0.0004 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.2019 1
Echinococcus granulosus chromobox protein 1 0.0072 0.0822 0.1785
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.0000000010351
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0239 0.0239
Leishmania major UDP-galactopyranose mutase 0.0043 0.0426 0.2097
Toxoplasma gondii cathepsin CPL 0.0042 0.0411 0.383
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0091 0.1074 0.5311
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0411 0.1383
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0065 0.0724 0.1573
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0432 0.4019
Onchocerca volvulus 0.0012 0.0004 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0287 0.0287
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0214 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0687 0.0687
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0219 0.2805 0.6093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0411 0.0894
Entamoeba histolytica hypothetical protein 0.0037 0.0346 0.4331
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0287
Echinococcus granulosus lysine specific histone demethylase 1A 0.0213 0.2729 0.5928
Onchocerca volvulus 0.0078 0.0898 0.3022
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0287
Entamoeba histolytica hypothetical protein 0.0037 0.0346 0.4331
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0239 0.0239
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0091 0.0433
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0134 0.0646
Echinococcus multilocularis chromobox protein 1 0.0072 0.0822 0.1785
Brugia malayi PAS domain containing protein 0.0071 0.0808 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0134 0.0646
Schistosoma mansoni hypothetical protein 0.0154 0.1935 0.5178
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0687 0.0687
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0411 0.2022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0426 0.4746
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.025 0.233
Trichomonas vaginalis DNA helicase recq1, putative 0.0015 0.004 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Echinococcus multilocularis tumor protein p63 0.0351 0.4603 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0012 0.0004 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0411 0.0411
Brugia malayi Inositol-1 0.0028 0.0214 0.0214
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.000000000082814 0.0000000001799
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0687 0.0687
Schistosoma mansoni hypothetical protein 0.003 0.025 0.067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Trypanosoma cruzi major cysteine proteinase, putative 0.0126 0.1552 0.7685
Schistosoma mansoni nuclear receptor 0.0029 0.0239 0.064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0687 0.1838
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0346 0.0753
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.003 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0065 0.0724 0.0724
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0091 0.1074 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Trypanosoma cruzi cruzipain precursor, putative 0.0161 0.2019 1
Schistosoma mansoni hypothetical protein 0.0078 0.0898 0.2404
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0016 0.005 0.0469
Brugia malayi hypothetical protein 0.0033 0.0287 0.0287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Schistosoma mansoni coup transcription factor 0.0062 0.0687 0.1838
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0012 0.0004 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0214 0.1041
Schistosoma mansoni thyroid hormone receptor 0.0287 0.3738 1
Brugia malayi MAP kinase sur-1 0.0091 0.1074 0.1074
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0028 0.0122
Schistosoma mansoni thyroid hormone receptor 0.0287 0.3738 1
Brugia malayi SWIRM domain containing protein 0.0018 0.0084 0.0084
Entamoeba histolytica cysteine proteinase 1, putative 0.0022 0.0134 0.1674
Schistosoma mansoni DNA helicase recq5 0.0015 0.004 0.0107
Brugia malayi nuclear receptor RXR 0.0033 0.0287 0.0287
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0687 0.1492
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0287
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0687 0.2311
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0004 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0687 0.1492
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0264 0.3424 0.7438
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0046 0.046 0.0999
Echinococcus multilocularis Polycystic kidney disease protein 0.0078 0.0898 0.1952
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Echinococcus granulosus RUN 0.0078 0.0898 0.1952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.039 0.1311
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.0214 0.1988
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0426 0.4746
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Plasmodium vivax multidomain scavenger receptor, putative 0.0078 0.0898 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0025 0.0174 0.4035
Loa Loa (eye worm) hypothetical protein 0.0196 0.2494 0.2494
Schistosoma mansoni hypothetical protein 0.0264 0.3424 0.916
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0102 0.0488
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0028
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.004 0.0381 0.0381
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0015 0.0033
Brugia malayi chromobox protein homolog 3 0.0041 0.039 0.039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0058 0.0156
Loa Loa (eye worm) PHD-finger family protein 0.003 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0213 0.2729 0.2729
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.0058 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.025
Trichomonas vaginalis guanylate cyclase, putative 0.0019 0.0091 0.0847
Brugia malayi cathepsin L-like precursor 0.0028 0.0222 0.0222
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0013 0.0015 0.0033
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0426 0.2097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0222 0.0222
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0042 0.0411 0.4579
Echinococcus multilocularis hyperpolarization activated cyclic 0.0016 0.0058 0.0127
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.0000000010351
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0042 0.0411 0.4579
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0012 0.0004 0.001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0015 0.004 0.004
Toxoplasma gondii bicoid-interacting protein BIN3 0.0016 0.005 0.0469
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0012 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0411 0.5141
Echinococcus granulosus peregrin 0.003 0.025 0.0544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.000000000082814 0.0000000001799
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.003 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0687 0.1492
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0287 0.0287
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.000000000082814 0.0000000001799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0239 0.0239
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0687 0.1492
Brugia malayi jmjC domain containing protein 0.0037 0.0337 0.0337
Plasmodium falciparum phd finger protein, putative 0.003 0.025 0.2786
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0411 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0229 0.2133
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0134 0.0134
Echinococcus granulosus aryl hydrocarbon receptor 0.0154 0.1932 0.4196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0239 0.0519
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0048 0.0495 0.2438
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.004 0.018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0537 0.1435
Loa Loa (eye worm) Carm1-pending protein 0.0016 0.005 0.005
Echinococcus granulosus cysteine protease 0.0022 0.0134 0.0291
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0134 0.1674
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0239 0.0519
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0214 0.0464
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0239 0.0804
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0147 0.183 0.9061
Loa Loa (eye worm) hypothetical protein 0.0012 0.000000000082814 0.000000000082814
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0004 0.0035
Schistosoma mansoni nuclear receptor 0.0029 0.0239 0.064
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0822 0.7649
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0012 0.0004 0.0042
Brugia malayi nuclear receptor NHR-88 0.0062 0.0687 0.0687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.004 0.0373
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0426 0.765
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0426 0.9269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.003 0.0278
Schistosoma mansoni polycystin 1-related 0.0078 0.0898 0.2404
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0055 0.0589 0.1576
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0004 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0411 0.0894
Brugia malayi hypothetical protein 0.0078 0.0898 0.0898
Onchocerca volvulus 0.0062 0.0687 0.2311
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0091 0.0847
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Loa Loa (eye worm) apoptosis regulator protein 0.0264 0.3424 0.3424
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0135 0.0135
Schistosoma mansoni inositol monophosphatase 0.0028 0.0214 0.0571
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0822 0.0822
Onchocerca volvulus Cathepsin F homolog 0.0042 0.0411 0.1383
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0687 0.0687
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0239 0.064
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0058 0.0156
Loa Loa (eye worm) inositol-1 0.0028 0.0214 0.0214
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0214 0.1988
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Plasmodium vivax vivapain-1 0.0022 0.0134 0.1491
Echinococcus multilocularis 0.0043 0.0426 0.0926
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0222 0.2069
Brugia malayi bHLH-PAS transcription factor 0.0053 0.0556 0.0556
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0091 0.1074 0.1074
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0014 0.0034 0.009
Schistosoma mansoni amine oxidase 0.0043 0.0426 0.1141
Plasmodium vivax hypothetical protein, conserved 0.003 0.025 0.2786
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0016 0.005 0.0469
Entamoeba histolytica hypothetical protein 0.0037 0.0346 0.4331
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0239 0.0519
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0058 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0022 0.0134 0.0646
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.2019 1
Brugia malayi Cathepsin L-like precursor 0.0042 0.0411 0.0411
Echinococcus multilocularis transcription factor Dp 1 0.0028 0.0219 0.0475
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0012 0.0004 0.0004
Mycobacterium ulcerans oxidoreductase 0.0043 0.0426 0.765
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0019 0.0102 0.0488
Brugia malayi follicle stimulating hormone receptor 0.0173 0.2186 0.2186
Leishmania major cathepsin L-like protease 0.0042 0.0411 0.2022
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0004 0.0008
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0055 0.0589 0.5483
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0687 0.0687
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0239 0.064
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0019 0.0091 0.0847
Onchocerca volvulus 0.0029 0.0239 0.0804
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.046 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0058 0.0127
Echinococcus granulosus lipoxygenase domain containing protein 0.0078 0.0898 0.1952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Onchocerca volvulus 0.0042 0.0411 0.1383
Loa Loa (eye worm) hypothetical protein 0.0033 0.0287 0.0287
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0337 0.0337
Schistosoma mansoni lipoxygenase 0.0078 0.0898 0.2404
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0337 0.0901
Onchocerca volvulus Alhambra homolog 0.003 0.025 0.0842
Leishmania major arginine N-methyltransferase-like protein 0.0057 0.0618 0.3049
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0012 0.0004 0.001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0091 0.1074 0.5311
Leishmania major cathepsin L-like protease 0.0042 0.0411 0.2022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0687 0.1838
Loa Loa (eye worm) hypothetical protein 0.0042 0.0411 0.0411
Loa Loa (eye worm) cysteine protease 0.0042 0.0411 0.0411
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.025 0.0544
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.000000000082814 0.00000000022156
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.046 0.8253
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0239 0.0239
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0135 0.0293
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1186 0.2575
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0687 0.1492
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0071 0.08 0.3951
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1074 0.2873
Echinococcus granulosus cGMP dependent protein kinase 0.0013 0.0015 0.0033
Giardia lamblia Kinase, CMGC MAPK 0.0091 0.1074 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0134 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0411 0.383
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0134 0.1674
Entamoeba histolytica cysteine proteinase 2 0.0022 0.0134 0.1674
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0019 0.0102 0.0488
Onchocerca volvulus 0.0042 0.0411 0.1383
Brugia malayi hypothetical protein 0.0078 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0136 0.168 0.168
Giardia lamblia PHD finger protein 15 0.003 0.025 0.2303
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0687 0.1838
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0015 0.004 0.0087
Onchocerca volvulus 0.0042 0.0411 0.1383
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0019 0.0091 0.0433
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0065 0.0724 0.1573
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0091 0.2063
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0135
Schistosoma mansoni hypothetical protein 0.0037 0.0346 0.0927
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0214 0.1041
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0239 0.0519
Echinococcus granulosus cathepsin l cysteine peptidase 0.0042 0.0411 0.0894
Plasmodium falciparum LCCL domain-containing protein 0.0078 0.0898 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.08 0.08
Plasmodium vivax vivapain-3 0.0022 0.0134 0.1491
Onchocerca volvulus 0.0042 0.0411 0.1383
Brugia malayi ecdysteroid receptor 0.0062 0.0687 0.0687
Entamoeba histolytica cysteine protease, putative 0.0042 0.0411 0.5141
Loa Loa (eye worm) hypothetical protein 0.0041 0.039 0.039
Entamoeba histolytica hypothetical protein 0.0018 0.0084 0.1046
Schistosoma mansoni inositol monophosphatase 0.0028 0.0214 0.0571
Schistosoma mansoni ap endonuclease 0.0014 0.003 0.008
Toxoplasma gondii SWIRM domain-containing protein 0.0018 0.0084 0.0779
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0012 0.0004 0.0042
Mycobacterium leprae Possible regulatory protein 0.0019 0.0091 0.2063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0687 0.1492
Echinococcus granulosus Polycystic kidney disease protein 0.0078 0.0898 0.1952
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.004 0.0373
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0239 0.0519
Echinococcus multilocularis cysteine protease 0.0042 0.0411 0.0894
Loa Loa (eye worm) hypothetical protein 0.0135 0.1671 0.1671
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.0801 0.2142
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0134 0.1674
Brugia malayi ecdysone receptor 0.0029 0.0239 0.0239
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0012 0.0004 0.0035
Onchocerca volvulus 0.0042 0.0411 0.1383
Brugia malayi N-terminal motif family protein 0.0196 0.2494 0.2494
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0214 0.1988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0225 0.289 0.6278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0687 0.0687
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.067 0.6235
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0048 0.0495 0.2438
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0287 0.0624
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0043 0.0426 0.765
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0022 0.0134 0.0358
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.046 0.8253
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.067 0.6235
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0019 0.0099 0.0216
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0687 0.2311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0687 0.0687
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0012 0.0004 0.0035
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.004 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0411 0.383
Loa Loa (eye worm) AGC/PKG protein kinase 0.0013 0.0015 0.0015
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1186 0.2575
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.003 0.0278
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0239 0.0239
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0091 0.1074 0.5311
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0091 0.1074 0.5311
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0264 0.3424 0.7438
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.003 0.0243
Echinococcus granulosus lipoxygenase domain containing protein 0.0078 0.0898 0.1952
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0239 0.064
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0337 0.0732
Brugia malayi Bloom's syndrome protein homolog 0.0015 0.004 0.004
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0012 0.0004 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.003 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Echinococcus granulosus cathepsin l1 0.0028 0.0222 0.0483
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0239 0.0519
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0058 0.0127
Echinococcus multilocularis protein arginine methyltransferase 0.0055 0.0589 0.1279
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0055 0.0589 0.1279
Schistosoma mansoni rab6-interacting 0.0078 0.0898 0.2404
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0012 0.0004 0.0035
Echinococcus granulosus hyperpolarization activated cyclic 0.0016 0.0058 0.0127
Schistosoma mansoni hypothetical protein 0.0154 0.1935 0.5178
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0426 0.0926
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0909 0.2431
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0432 0.4019
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0287 0.0624
Echinococcus granulosus chromobox protein 1 0.0072 0.0822 0.1785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0028 0.0214 0.2669
Echinococcus granulosus patatin phospholipase domain containing protein 0.0012 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.0847
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0019 0.0091 0.0847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0239 0.0239
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.000000000082814 0.00000000022156
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0687 0.1492
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0043 0.0426 0.765
Leishmania major protein kinase, putative 0.0019 0.0102 0.0488
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.363
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.000000000082814 0.000000000082814
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0019 0.0099 0.0099
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0426 1
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0055 0.0589 0.6555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0687 0.0687
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0687 0.0687
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0135 0.036
Loa Loa (eye worm) RecQ helicase 0.0015 0.004 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.003 0.0373
Echinococcus granulosus protein arginine methyltransferase 0.0055 0.0589 0.1279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Echinococcus granulosus transcription factor Dp 1 0.0028 0.0219 0.0475
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0264 0.3424 0.7438
Entamoeba histolytica cysteine protease, putative 0.0022 0.0134 0.1674
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0058 0.0058
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0018 0.0084 0.0182
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Loa Loa (eye worm) hypothetical protein 0.0062 0.0687 0.0687
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0015 0.004 0.004
Brugia malayi amine oxidase, flavin-containing family protein 0.0061 0.0671 0.0671
Echinococcus granulosus cathepsin l1 0.0042 0.0411 0.0894
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.025 0.067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.000000000082814 0.00000000077107
Schistosoma mansoni hypothetical protein 0.0012 0.000000000082814 0.00000000022156
Loa Loa (eye worm) hypothetical protein 0.0213 0.2729 0.2729
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.003 0.0129
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0213 0.2729 0.5928
Echinococcus multilocularis mitogen activated protein kinase 0.0091 0.1074 0.2333
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0091 0.1074 0.5311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0687 0.0687
Brugia malayi hypothetical protein 0.0029 0.0239 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.039 0.363
Leishmania major arginine N-methyltransferase, type I 0.0016 0.005 0.0231
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0264 0.3424 0.3424
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0687 0.0687
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0411 0.11
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0012 0.0004 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0411 0.5141
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.0847
Brugia malayi Heterochromatin protein 1 0.0072 0.0822 0.0822
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0091 0.1074 0.5311
Echinococcus granulosus bloom syndrome protein 0.0015 0.004 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Echinococcus granulosus tumor protein p63 0.0351 0.4603 1
Trypanosoma cruzi cruzipain precursor, putative 0.0014 0.0028 0.0122
Brugia malayi Bromodomain containing protein 0.003 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0239
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0239 0.0239
Echinococcus granulosus single minded 2 0.0058 0.0632 0.1374
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0058 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0043 0.0426 0.0426
Echinococcus granulosus methyltransferase protein 5 0.0016 0.005 0.0109
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.025 0.233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0411 0.383
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.000000000082814 0.00000000092181
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0012 0.0004 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0173 0.2186 0.2186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.2019 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0048 0.0495 0.1075
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0055 0.0589 0.1576
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0028 0.0028
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.0214 0.1988
Plasmodium vivax hypothetical protein, conserved 0.0012 0.000000000082814 0.00000000092181
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0214 0.1041
Leishmania major cathepsin L-like protease 0.0161 0.2019 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0055 0.0589 0.5483
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0687 0.1838
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0135 0.0293
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.004 0.0373
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0012 0.0004 0.001
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0018 0.0084 0.0182
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0015 0.004 0.004
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0016 0.005 0.0231
Schistosoma mansoni chromobox protein 0.0072 0.0822 0.2198
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0015 0.004
Plasmodium vivax unspecified product 0.0014 0.0028 0.0316
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0071 0.08 0.3951
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0687 0.1492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0411 0.383
Schistosoma mansoni rab6-interacting 0.0078 0.0898 0.2404

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.8 nM Inhibitory activity of compound against angiotensin I converting enzyme was determined ChEMBL. 15125946
IC50 (binding) = 3.8 nM Inhibitory activity of compound against angiotensin I converting enzyme was determined ChEMBL. 15125946
Relative potency (binding) = 3.8 Relative potency of compound was determined ChEMBL. 15125946
Relative potency (binding) = 3.8 Relative potency of compound was determined ChEMBL. 15125946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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