Detailed information for compound 16147

Basic information

Technical information
  • TDR Targets ID: 16147
  • Name: 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylb utane
  • MW: 182.173 | Formula: C7H16FO2P
  • H donors: 0 H acceptors: 1 LogP: 2.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(C)(C)C)OP(=O)(F)C
  • InChi: 1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3
  • InChiKey: GRXKLBBBQUKJJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethyl-butane
  • [fluoro(1,2,2-trimethylpropoxy)phosphoryl]methane
  • Soman
  • 2,3-4,5-di-O-isopropylidene-1-O-methyl-beta-fructopyranose
  • 3,3-dimethyl-2-butyl methylphosphonofluoridate
  • 3-(fluoro-methylphosphoryl)oxy-2,2-dimethylbutane
  • 3-(fluoro-methyl-phosphoryl)oxy-2,2-dimethyl-butane
  • (fluoro-(1,2,2-trimethylpropoxy)phosphoryl)methane
  • 68190-07-8
  • 96-64-0
  • O-Pinacolyl methylphosphonofluoridate
  • C07494
  • 1,2,2-Trimethylpropyl methylphosphonofluoridate
  • 1,2,2-Trimethylpropylester kyseliny methylfluorfosfonove [Czech]
  • 1-Methyl-2,2-dimethylpropylmethylphosphonofluoridate
  • 2-Butanol, 3,3-dimethyl-, methylphosphonofluoridate
  • 3,3-Dimethyl-n-but-2-yl methylphosphonofluoridate
  • BRN 1928737
  • CCRIS 3417
  • EA 1210
  • HSDB 6764
  • Methyl pinacolyl phosphonofluoridate
  • Methyl pinacolyloxy phosphorylfluoride
  • Methylfluorphosphorsaeurepinakolylester [German]
  • Methylphosphonofluoridic acid 1,2,2-trimethylpropyl ester
  • Methylphosphonofluoridic acid, 3,3-dimethyl-2-butyl ester
  • PMFP
  • Phosphine oxide, fluoromethyl(1,2,2-trimethylpropoxy)-
  • Phosphonofluoridic acid, methyl-, 1,2,2-trimethylpropyl ester
  • Pinacoloxymethylphosphoryl fluoride
  • Pinacolyl methylfluorophosphonate
  • Pinacolyl methylphosphonofluoridate
  • Pinacolyl methylphosphonofluoride
  • Pinacolyloxy methylphosphoryl fluoride
  • Pynacolyl methylfluorophosphonate
  • T.2107
  • Zoman

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Electrophorus electricus Acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   633 aa 690 aa 32.3 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   633 aa 622 aa 24.9 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 576 aa 23.4 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 517 aa 25.1 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 597 aa 25.1 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   633 aa 690 aa 31.7 %
Onchocerca volvulus Acetylcholinesterase   633 aa 648 aa 25.3 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   633 aa 507 aa 23.9 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   633 aa 576 aa 28.8 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   633 aa 549 aa 30.4 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 620 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0092 0.0341
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0107 0.0247
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0076 0.0076
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0206 0.0561 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.001 0.001
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2017 0.5891 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0313 1
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0072 0.0268
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0051 0.0909
Schistosoma mansoni coup transcription factor 0.004 0.0072 0.0165
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.001 0.0032
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.001 0.001
Onchocerca volvulus Poor gastrulation protein homolog 0.0016 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2469
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0063 0.0141 0.0428
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Schistosoma mansoni serine-rich repeat protein 0.0802 0.2314 0.5336
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0133 0.0403
Brugia malayi ecdysteroid receptor 0.004 0.0072 0.0268
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.008 0.008
Brugia malayi hypothetical protein 0.0029 0.004 0.015
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.001 0.001
Schistosoma mansoni slit 0.0052 0.0107 0.0247
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0051 0.148
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0211 0.0786
Brugia malayi Cache domain containing protein 0.0687 0.1977 0.7388
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.04
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0206 0.0561 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0072
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0047 0.0047
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0751 0.2164 0.4989
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0019 0.0019
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0103 0.0257 0.0257
Onchocerca volvulus 0.0087 0.0211 0.0689
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0076 0.0076
Loa Loa (eye worm) PXA domain-containing protein 0.0043 0.008 0.03
Loa Loa (eye worm) LGC-31 protein 0.0019 0.001 0.0036
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0032 0.056
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0019 0.0019
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0019 0.0141
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0155
Brugia malayi Nuclear hormone receptor E75 0.0019 0.001 0.0036
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0019 0.055
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0135 0.0135
Leishmania major hypothetical protein, conserved 0.0029 0.004 0.0521
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0029 0.0107
Schistosoma mansoni regulator of G protein signaling 0.0043 0.008 0.0185
Brugia malayi hypothetical protein 0.0063 0.0141 0.0526
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0017 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0072
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0076 0.0076
Loa Loa (eye worm) RecQ helicase 0.0045 0.0087 0.0326
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0096 0.022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Brugia malayi hypothetical protein 0.0042 0.0077 0.0288
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.001 0.001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0043 0.008 0.03
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0083 0.0198 0.0197
Echinococcus multilocularis GPCR, family 3, C terminal 0.0016 0.0001 0.0001
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.0313 0.0313
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0211 0.0786
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0313 0.0994
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.0735 0.0734
Brugia malayi steroid hormone receptor 0.004 0.0072 0.0268
Schistosoma mansoni regulator of G protein signaling 0.0043 0.008 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0561 1
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0043
Onchocerca volvulus 0.0063 0.0141 0.0461
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0051 0.0133
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0051 0.3298
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.001 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0076 0.0176
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0273
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0133 0.0346 0.1294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0324
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0012 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.004 0.0717
Brugia malayi conserved hypotetical protein 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Schistosoma mansoni lipoxygenase 0.0022 0.0019 0.0043
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3414 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0005
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0051 0.0909
Loa Loa (eye worm) phosphofructokinase 0.0122 0.0313 0.1169
Entamoeba histolytica hypothetical protein, conserved 0.0063 0.0141 0.4502
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0072 0.0235
Brugia malayi hypothetical protein 0.0019 0.0011 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0077 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0561 0.1294
Mycobacterium ulcerans hypothetical protein 0.0022 0.0019 0.0141
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.001 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0087 0.0252
Brugia malayi intermediate filament protein 0.0087 0.0211 0.0786
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0114 0.0423
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0051 0.2573
Echinococcus multilocularis thyroid hormone receptor alpha 0.0326 0.0915 0.0915
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0076 0.0076
Echinococcus granulosus acetylcholinesterase 0.0082 0.0195 0.0195
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0076 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0133 0.4229
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.001 0.0036
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.008 0.03
Loa Loa (eye worm) glutamate receptor 0.0039 0.0069 0.0255
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0199 0.5731
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.001 0.001
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0019 0.007
Plasmodium falciparum thrombospondin-related anonymous protein 0.0063 0.0141 0.7093
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0096 0.0357
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Toxoplasma gondii exonuclease III APE 0.0061 0.0133 0.2373
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0051 0.0087
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0063 0.0141 0.0141
Brugia malayi Pre-SET motif family protein 0.0925 0.2676 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Echinococcus granulosus GPCR family 3 C terminal 0.0016 0.0001 0.0001
Brugia malayi laminin alpha chain 0.0052 0.0107 0.04
Schistosoma mansoni rab6-interacting 0.0022 0.0019 0.0043
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Onchocerca volvulus 0.0019 0.001 0.0032
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0287 0.0798 0.0797
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.001 0.001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.008 0.03
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0047 0.0047
Loa Loa (eye worm) CUTiclin-Like family member 0.0063 0.0141 0.0526
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0133 0.0498
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0077 0.0077
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0061 0.196
Onchocerca volvulus 0.0087 0.0211 0.0689
Entamoeba histolytica hypothetical protein 0.0063 0.0141 0.4502
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.004 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0561 1
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.0313 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0165 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0133 0.0346 0.0798
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0001 0.0005
Plasmodium vivax amine transporter, putative 0.0016 0 0.0007
Onchocerca volvulus 0.0057 0.0123 0.0404
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0063 0.0141 0.0526
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0072 0.0072
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.001 0.001
Echinococcus granulosus metabotropic glutamate receptor 5 0.0121 0.0312 0.0311
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0925 0.2676 1
Loa Loa (eye worm) hypothetical protein 0.0687 0.1977 0.7388
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0313 0.0994
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0313 0.1169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0061
Schistosoma mansoni hypothetical protein 0.0063 0.0141 0.0324
Echinococcus granulosus lamin 0.0087 0.0211 0.021
Schistosoma mansoni loxhd1 0.0022 0.0019 0.0043
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.001 0.0036
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0258 0.0714 0.1646
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0133 0.3851
Echinococcus multilocularis Regulator of G protein signaling 20 0.0043 0.008 0.008
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0063 0.0141 0.4067
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Schistosoma mansoni intermediate filament proteins 0.0087 0.0211 0.0485
Echinococcus granulosus leukotriene A 4 hydrolase 0.0258 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0083 0.0199 0.0741
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0076 0.5347
Schistosoma mansoni regulator of G protein signaling 0.0043 0.008 0.0185
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2469
Brugia malayi 6-phosphofructokinase 0.0122 0.0313 0.1169
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0016 0.0001 0.0004
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0043 0.008 0.0185
Echinococcus multilocularis expressed protein 0.0835 0.2411 0.241
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.04
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.0313 0.5489
Echinococcus multilocularis tumor protein p63 0.0392 0.1109 0.1109
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0313 1
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.008 0.008
Schistosoma mansoni lamin 0.0087 0.0211 0.0485
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0076 0.0176
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Schistosoma mansoni axis inhibition protein axin 0.0043 0.008 0.0185
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.001 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0206 0.0561 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.0313 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.001 0.001
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.0313 0.5489
Echinococcus granulosus acetylcholinesterase 0.0082 0.0195 0.0195
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Echinococcus multilocularis lamin dm0 0.0087 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0006
Onchocerca volvulus 0.0054 0.0114 0.0371
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.008 0.008
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.001 0.0036
Brugia malayi hypothetical protein 0.0022 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0165 0.5233
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Treponema pallidum 76K protein 0.0063 0.0141 0.0239
Schistosoma mansoni ap endonuclease 0.0061 0.0133 0.0307
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.001 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0133 0.2212
Echinococcus multilocularis musashi 0.0087 0.0211 0.021
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.008 0.008
Schistosoma mansoni nuclear receptor 0.0019 0.001 0.0022
Mycobacterium ulcerans endonuclease IV 0.0083 0.0199 0.341
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.001 0.0036
Brugia malayi nuclear receptor NHR-88 0.0019 0.001 0.0036
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0324
Loa Loa (eye worm) glutamate receptor 0.0099 0.0245 0.0913
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.001 0.0022
Echinococcus multilocularis pikachurin 0.0052 0.0107 0.0107
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.001 0.001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0313 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0063 0.0141 0.0526
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0076 0.1174
Echinococcus multilocularis dna polymerase eta 0.002 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0268
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0133 0.0133
Onchocerca volvulus 0.0019 0.001 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0072 0.0072
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0056 0.0797
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.004 0.095
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0268
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0313 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1489 0.4337 1
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0107 0.0247
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.004 0.1243
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.001 0.001
Loa Loa (eye worm) carboxylesterase 0.0082 0.0195 0.0729
Schistosoma mansoni hypothetical protein 0.0802 0.2314 0.5336
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0047 0.238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0072 0.0165
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0029 0.0107
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0063 0.0141 0.0526
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0017 0.0061
Echinococcus granulosus histone lysine methyltransferase setb 0.0133 0.0346 0.0346
Brugia malayi Carboxylesterase family protein 0.0082 0.0195 0.0729
Onchocerca volvulus 0.0133 0.0346 0.1135
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.008 0.008
Schistosoma mansoni DNA helicase recq5 0.0032 0.0047 0.0109
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0165 0.0615
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.004 0.203
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0285
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0049 0.0181
Treponema pallidum hypothetical protein 0.0063 0.0141 0.0239
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0076 0.2142
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0072 0.0072
Brugia malayi Cation transporter family protein 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.004
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0199 0.341
Trichomonas vaginalis set domain proteins, putative 0.1052 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0061
Echinococcus granulosus voltage dependent calcium channel subunit 0.1553 0.4523 0.4523
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0135 0.0135
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0072 0.0165
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0051 0.0909
Echinococcus granulosus nAChR subunit 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0265 0.0735 0.2745
Brugia malayi nuclear hormone receptor 0.004 0.0072 0.0268
Loa Loa (eye worm) ACC-1 protein 0.0019 0.001 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0268
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0133 0.0346 0.0346
Echinococcus granulosus lamin dm0 0.0087 0.0211 0.021
Brugia malayi regulator of G-protein signaling egl-10 0.0043 0.008 0.03
Schistosoma mansoni hypothetical protein 0.0042 0.0077 0.0178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0072
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0012 0.0027
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.001 0.0036
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.001 0.001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0076 0.2396
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0078 0.0078
Plasmodium vivax SET domain protein, putative 0.0133 0.0346 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0043 0.008 0.008
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0103 0.0257 0.0257
Brugia malayi nuclear receptor NHR-88 0.004 0.0072 0.0268
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0128 0.033 0.033
Schistosoma mansoni lamin 0.0087 0.0211 0.0485
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0087 0.0087
Echinococcus granulosus tumor protein p63 0.0392 0.1109 0.1109
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.001 0.001
Brugia malayi nuclear receptor RXR 0.0021 0.0017 0.0061
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0063 0.0141 0.4067
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0915 0.211
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0012 0.0027
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0079 0.3976
Brugia malayi PXA domain containing protein 0.0043 0.008 0.03
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.004 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Brugia malayi hypothetical protein 0.0021 0.0017 0.0061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0002 0.0028
Onchocerca volvulus 0.0019 0.001 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0176
Loa Loa (eye worm) DR-78 0.0019 0.001 0.0036
Onchocerca volvulus 0.0063 0.0141 0.0461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0047 0.0176
Onchocerca volvulus 0.0022 0.0019 0.0062
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0709 0.2042 0.7631
Brugia malayi phosphofructokinase 0.0122 0.0313 0.1169
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.001 0.0036
Schistosoma mansoni hypothetical protein 0.0287 0.0798 0.1839
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.008 0.008
Echinococcus granulosus bloom syndrome protein 0.0045 0.0087 0.0087
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0165 0.2781
Brugia malayi hypothetical protein 0.0019 0.001 0.0036
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.001 0.0036
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0027 0.0033 0.0966
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0268
Echinococcus granulosus slit 2 protein 0.0052 0.0107 0.0107
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0017 0.0016
Brugia malayi hypothetical protein 0.0272 0.0755 0.2822
Schistosoma mansoni zinc finger protein 0.0019 0.001 0.0022
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.001 0.0022
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.001 0.0036
Schistosoma mansoni hypothetical protein 0.0189 0.051 0.1176
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0076 0.0285
Brugia malayi nuclear receptor NHR-67 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0056 0.1731
Schistosoma mansoni nuclear hormone receptor 0.0019 0.001 0.0022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0017 0.0038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0072
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0051 0.2573
Brugia malayi PXA domain containing protein 0.0043 0.008 0.03
Loa Loa (eye worm) hypothetical protein 0.0082 0.0195 0.0729
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0133 0.4229
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0268
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0064 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0313 0.0994
Onchocerca volvulus 0.0063 0.0141 0.0461
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0147 0.2619
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0076 0.0076
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0313 0.0721
Schistosoma mansoni cpg binding protein 0.0032 0.0049 0.0111
Schistosoma mansoni regulator of G protein signaling 0.0043 0.008 0.0185
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.001 0.001
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0121 0.0312 0.1164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0133 0.0498
Onchocerca volvulus 0.0022 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.001 0.001
Onchocerca volvulus 0.1052 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Mycobacterium ulcerans epimerase 0.0022 0.0019 0.0141
Brugia malayi A-kinase anchor protein 10, precursor 0.0043 0.008 0.03
Plasmodium vivax thrombospondin-related anonymous protein 0.0063 0.0141 0.4067
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.001 0.001
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.001 0.0036
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0029 0.0107
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0076 0.0216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Loa Loa (eye worm) CUTiclin family member 0.0063 0.0141 0.0526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.001 0.001
Echinococcus multilocularis geminin 0.0189 0.051 0.051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0133 0.0346 0.0798
Echinococcus multilocularis lamin 0.0087 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.001 0.0036
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.0257 0.0593
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.001 0.0036
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0051 0.1638
Echinococcus granulosus Regulator of G protein signaling 20 0.0043 0.008 0.008
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0195 0.0195
Brugia malayi Cation transporter family protein 0.0019 0.001 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0268
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.004 0.203
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0199 0.0741
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.001 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0017 0.0061
Schistosoma mansoni hypothetical protein 0.0063 0.0141 0.0324
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.001 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0133 0.0346 0.617
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0047 0.0047
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0019 0.006
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0061 0.1089
Schistosoma mansoni cpg binding protein 0.0034 0.0054 0.0124
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0019 0.0019
Brugia malayi hypothetical protein 0.0119 0.0304 0.1134
Echinococcus granulosus FTZ F1 alpha 0.004 0.0072 0.0072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0019 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0072
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0313 0.1169
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2469
Brugia malayi Zona pellucida-like domain containing protein 0.0063 0.0141 0.0526
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.008 0.03
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0002 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0133 1
Entamoeba histolytica hypothetical protein 0.0043 0.008 0.2571
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0107 0.04
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0206 0.0561 0.0561
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.0735 0.0734
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0087 0.0252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0133 0.0346 0.0798
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0092 0.0341
Brugia malayi Cation transporter family protein 0.0019 0.001 0.0036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.001 0.001
Brugia malayi follicle stimulating hormone receptor 0.0265 0.0734 0.2744
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1553 0.4523 0.4523
Brugia malayi Zona pellucida-like domain containing protein 0.0063 0.0141 0.0526
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0047 0.0176
Brugia malayi nuclear receptor RXR 0.0019 0.001 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0169 0.0388
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0051 0.2573
Loa Loa (eye worm) ACC-1 protein 0.0019 0.001 0.0036
Echinococcus granulosus expressed protein 0.0835 0.2411 0.241
Schistosoma mansoni axis inhibition protein axin 0.0043 0.008 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0268
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0133 0.0346 0.0346
Onchocerca volvulus 0.0063 0.0141 0.0461
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0112 0.0284 0.0655
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0061 0.1643
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Trichomonas vaginalis rotamase, putative 0.0036 0.0061 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0016 0 0.0007
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.008 0.03
Schistosoma mansoni rotamase 0.0037 0.0064 0.0147
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0072 0.0268
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0061 0.09
Schistosoma mansoni aldehyde dehydrogenase 0.0206 0.0561 0.1294
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0165 0.5261
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0012 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0268
Loa Loa (eye worm) hypothetical protein 0.0085 0.0206 0.0768
Onchocerca volvulus 0.0063 0.0141 0.0461
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0199 1
Echinococcus multilocularis RUN 0.0022 0.0019 0.0019
Brugia malayi nuclear hormone receptor 0.0019 0.001 0.0036
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0072
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Echinococcus granulosus dna polymerase kappa 0.002 0.0012 0.0012
Schistosoma mansoni rab6-interacting 0.0022 0.0019 0.0043
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.001 0.0022
Brugia malayi Metabotropic glutamate receptor precursor. 0.0099 0.0245 0.0913
Schistosoma mansoni DNA helicase recq1 0.0032 0.0047 0.0109
Schistosoma mansoni metabotropic glutamate receptor 0.0083 0.0198 0.0455
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0107 0.04
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0133 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Brugia malayi Carboxylesterase family protein 0.0082 0.0195 0.0729
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Schistosoma mansoni cell polarity protein 0.0052 0.0107 0.0247
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0012 0.0324
Brugia malayi von Willebrand Factor 0.0063 0.0141 0.0526
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Brugia malayi CXXC zinc finger family protein 0.0032 0.0049 0.0181
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0051 0.148
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.008 0.0185
Onchocerca volvulus 0.0019 0.001 0.0031
Onchocerca volvulus 0.0063 0.0141 0.0461
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0043 0.008 0.008
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0011 0.0035
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0043 0.008 0.0229
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0089 0.0217 0.0811
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0206 0.0561 0.0561
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.001 0.0036
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.008 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0313 0.0994
Onchocerca volvulus 0.0019 0.001 0.0031
Brugia malayi hypothetical protein 0.0022 0.0019 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0072 0.0165
Brugia malayi Sulfatase family protein 0.0019 0.0011 0.004
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0107 0.04
Entamoeba histolytica hypothetical protein 0.0043 0.008 0.2571
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0195 0.0195
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0047 0.0841
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.004 0.1243
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0019 0.0069
Echinococcus granulosus collagen alpha 1VII chain 0.0063 0.0141 0.0141
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Brugia malayi hypothetical protein 0.0019 0.001 0.0036
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.001 0.001
Onchocerca volvulus 0.004 0.0072 0.0235
Echinococcus granulosus dna polymerase eta 0.002 0.0012 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0133 0.6715
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0051 0.2573
Entamoeba histolytica recQ family helicase, putative 0.0034 0.0056 0.1779
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0061 0.1913
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0313 1
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0195 0.0195
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0061 0.1913
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0133 0.4036
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0133 0.0226
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Brugia malayi hypothetical protein 0.0043 0.008 0.03
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0133 0.4262
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.001 0.001
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.001 0.0036
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0121 0.0312 0.0311
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.001 0.001
Echinococcus granulosus cpg binding protein 0.0034 0.0054 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0141 0.4067
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.1296 0.1296
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0076 0.2396
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0268
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0072 0.0165
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0047 0.2986
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Loa Loa (eye worm) hypothetical protein 0.0103 0.0257 0.0961
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0019 0.0948
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Schistosoma mansoni nuclear receptor 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.001 0.001
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0063 0.0141 0.4067
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Giardia lamblia DINP protein human, muc B family 0.002 0.0012 0.0085
Brugia malayi Nuclear hormone receptor E75 0.0019 0.001 0.0036
Loa Loa (eye worm) RGS-3 protein 0.0043 0.008 0.03
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0047 0.0841
Echinococcus granulosus dnaJ subfamily B 0.0456 0.1296 0.1296
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0064 0.0175
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0076 0.0216
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.001 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0313 0.0721
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.001 0.001
Brugia malayi tailless protein 0.0019 0.001 0.0036
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0056 0.1455
Brugia malayi Cytochrome P450 family protein 0.0051 0.0104 0.0386
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.0734 0.2744
Schistosoma mansoni hypothetical protein 0.0189 0.051 0.1176
Toxoplasma gondii endonuclease IV APN 0.0083 0.0199 0.3534
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Echinococcus granulosus metabotropic glutamate receptor 2 0.0083 0.0198 0.0197
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0258 0.0714 0.2668
Brugia malayi hypothetical protein 0.0021 0.0017 0.0061
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.0257 0.0593
Loa Loa (eye worm) hypothetical protein 0.0087 0.0211 0.0786
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0133 0.5
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0268
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.0313 1
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.008 0.008
Trichomonas vaginalis DNA helicase recq, putative 0.0034 0.0056 0.0148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0123 0.0284
Schistosoma mansoni polycystin 1-related 0.0022 0.0019 0.0043
Echinococcus multilocularis expressed protein 0.0037 0.0064 0.0064
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.008 0.0185
Echinococcus granulosus geminin 0.0189 0.051 0.051
Onchocerca volvulus 0.0032 0.0049 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0076 0.0216
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0061
Brugia malayi hypothetical protein 0.0019 0.001 0.0036
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.008 0.008
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0268
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.001 0.0022
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Toxoplasma gondii microneme protein MIC2 0.0063 0.0141 0.2507
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0133 0.2227
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.008 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0072 0.0268
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0063 0.0141 0.7093
Trichomonas vaginalis rotamase, putative 0.0037 0.0064 0.0175
Schistosoma mansoni z-protein (S1r protein) 0.0043 0.008 0.0185
Loa Loa (eye worm) hypothetical protein 0.0057 0.0123 0.046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0072 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0072
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0012 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0268
Echinococcus multilocularis cpg binding protein 0.0034 0.0054 0.0054
Brugia malayi hypothetical protein 0.0265 0.0735 0.2745
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0072 0.0165
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Schistosoma mansoni cpg binding protein 0.0034 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0063 0.0141 0.2507
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.001 0.0036
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0012 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.008 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0061
Echinococcus granulosus intermediate filament protein 0.0087 0.0211 0.021
Echinococcus multilocularis slit 2 protein 0.0052 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.008 0.0185
Echinococcus granulosus RUN 0.0022 0.0019 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0063 0.0141 0.4502
Brugia malayi regulator of G-protein signaling rgs-7 0.0043 0.008 0.03
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0063 0.0141 0.7093
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0072 0.0072
Schistosoma mansoni ap endonuclease 0.0061 0.0133 0.0307
Echinococcus granulosus axis inhibition protein axin 0.0043 0.008 0.008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0012 0.0019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.001 0.001
Treponema pallidum ATP-dependent DNA helicase 0.0016 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0268
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.001 0.0036
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.008 0.03
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0072 0.0235
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0072 0.0268
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0078 0.0078
Onchocerca volvulus 0.0019 0.001 0.0031
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0072 0.0165
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.001 0.001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.0257 0.0593
Onchocerca volvulus 0.0063 0.0141 0.0461
Loa Loa (eye worm) hypothetical protein 0.0103 0.0257 0.0961
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Chlamydia trachomatis endonuclease IV 0.0083 0.0199 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.001 0.0036
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0072 0.0235
Schistosoma mansoni regulator of G protein signaling 0.0043 0.008 0.0185
Schistosoma mansoni nAChR subunit 0.0019 0.001 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0268
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.001 0.001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0165 0.0615
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0069
Echinococcus multilocularis regulator of G protein signaling 0.0043 0.008 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0072 0.0165
Schistosoma mansoni DNA polymerase eta 0.002 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0526
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0287 0.0798 0.0797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.004
Brugia malayi Doublecortin family protein 0.0022 0.0019 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0268
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.2614 0.2614
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0077 0.0077
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.008 0.0185
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0199 0.6112
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0061
Schistosoma mansoni lipoxygenase 0.0062 0.0135 0.0312
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0076 0.244
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2469
Entamoeba histolytica hypothetical protein 0.0043 0.008 0.2571
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0072 0.0268
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0047 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0072 0.0165
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0165 0.5233
Onchocerca volvulus 0.0019 0.001 0.0031
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0087 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Schistosoma mansoni survival motor neuron protein 0.0054 0.0114 0.0261
Echinococcus multilocularis nAChR subunit 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0456 0.1296 0.2988
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0012 0.038
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0017 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0211 0.0786
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.001 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0141 0.0526
Echinococcus granulosus expressed protein 0.0037 0.0064 0.0064
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Loa Loa (eye worm) hypothetical protein 0.0082 0.0195 0.0729
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0324
Brugia malayi ecdysone receptor 0.0019 0.001 0.0036
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0165 0.5074
Entamoeba histolytica elongation factor-2 kinase, putative 0.0063 0.0141 0.4502
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0107 0.0107
Echinococcus granulosus axis inhibition protein axin 0.0043 0.008 0.008
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0268
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.008 0.008
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0258 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0043 0.008 0.03
Echinococcus multilocularis dna polymerase kappa 0.002 0.0012 0.0012
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.001 0.0036
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.008 0.0229
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.0313 0.5481
Schistosoma mansoni hypothetical protein 0.0054 0.0114 0.0261
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.001 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0051 0.0133
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0165 0.0164
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.001 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0133 0.2227
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0104 0.0386
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0915 0.211
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0036
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.001 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0072 0.0165
Brugia malayi Pre-SET motif family protein 0.0133 0.0346 0.1294
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0195 0.0195
Schistosoma mansoni nuclear hormone receptor 0.004 0.0072 0.0165
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0017 0.0061
Brugia malayi hypothetical protein 0.0043 0.008 0.03
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0072 0.0268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0206 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0107
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0195 0.0729
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.04
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0165 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0133 0.0346 0.0798
Onchocerca volvulus Putative nachr subunit 0.0019 0.001 0.0031
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0064 0.0238
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0273
Brugia malayi von Willebrand factor type A domain containing protein 0.0063 0.0141 0.0526
Onchocerca volvulus 0.0019 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0291
Brugia malayi 6-phosphofructokinase 0.0122 0.0313 0.1169
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.001 0.0022
Echinococcus granulosus pikachurin 0.0052 0.0107 0.0107
Brugia malayi EGF-like domain containing protein 0.0052 0.0107 0.04
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.001 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0195 0.045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0012 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0268

Activities

Activity type Activity value Assay description Source Reference
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 1 on rate of aging in 2 mL of cell suspension; Minus (-) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 2 on rate of aging in 2 mL of cell suspension; Minus (-) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 3 on rate of aging in 2 mL of cell suspension; Minus (-) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 4 on rate of aging in 2 mL of cell suspension; Minus (-) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 5 on rate of aging in 2 mL of cell suspension; Plus (+) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 6 on rate of aging in 2 mL of cell suspension; Plus (+) ChEMBL. 3965704
Distribution (ADMET) = 0 Distribution of rat erythrocytes for tube 7 on rate of aging in 2 mL of cell suspension; Plus (+) ChEMBL. 3965704
Kd (binding) = 6.1 10'-7M Binding affinity to electric eel AChE ChEMBL. 18479118

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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