Detailed information for compound 162429

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.464 | Formula: C23H25N3O
  • H donors: 0 H acceptors: 2 LogP: 4.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1[C@H]2CCC1C([C@@H](C2)c1ccc(cc1)C)c1onc(n1)c1ccccc1
  • InChi: 1S/C23H25N3O/c1-15-8-10-16(11-9-15)19-14-18-12-13-20(26(18)2)21(19)23-24-22(25-27-23)17-6-4-3-5-7-17/h3-11,18-21H,12-14H2,1-2H3/t18?,19-,20?,21?/m1/s1
  • InChiKey: WYJIEKRDCVWTRP-BJODSLRWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Entamoeba histolytica hypothetical protein 0.0019 0.0088 0.0501
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0043 0.0103
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0088 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0598 0.0686
Schistosoma mansoni opsin-like receptor 0.0031 0.0269 0.0308
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.005 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0096 0.0191
Trypanosoma cruzi trypanothione reductase, putative 0.0025 0.0173 0.1474
Plasmodium falciparum heterochromatin protein 1 0.0019 0.0088 0.1011
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0254 0.2175
Brugia malayi CHD4 protein 0.0021 0.0109 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0207 0.2879 0.2879
Echinococcus granulosus intermediate filament protein 0.0031 0.0262 0.03
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0419 0.115
Brugia malayi hypothetical protein 0.005 0.0537 0.1299
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0069 0.0782
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0254 0.0161
Echinococcus granulosus RUN 0.0017 0.005 0.0057
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0419 0.3581
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0537 0.0616
Echinococcus granulosus neuropeptide receptor 0.0031 0.0269 0.0308
Schistosoma mansoni neuropeptide receptor 0.0031 0.0269 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0262 0.03
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.0129 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0139 0.032
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0109 0.1244
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Echinococcus granulosus dnaJ subfamily B 0.0347 0.4946 0.567
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0212 0.1586
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0419 0.115
Entamoeba histolytica phosphofructokinase, putative 0.0092 0.1169 1
Trichomonas vaginalis rotamase, putative 0.0028 0.0222 0.0565
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0269 0.0269
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0173 0.1474
Brugia malayi jmjC domain containing protein 0.0078 0.096 0.2321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0165 0.2243 0.8814
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.009 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0222 0.0565
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0537 0.0616
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Plasmodium falciparum importin beta, putative 0.0024 0.0164 0.1881
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.1299
Loa Loa (eye worm) CYP4Cod1 0.0019 0.009 0.0217
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0165 0.2243 0.8325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Brugia malayi beta-lactamase family protein 0.0031 0.0254 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0254 0.0662
Mycobacterium tuberculosis Conserved protein 0.0031 0.0254 0.0943
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0741 0.85
Toxoplasma gondii phosphofructokinase PFKII 0.0025 0.0171 0.1957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0254 0.0292
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2583 0.2583
Brugia malayi Inositol-1 0.0031 0.0266 0.0644
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0269 0.0308
Echinococcus granulosus nuclear factor of activated T cells 5 0.0062 0.0728 0.0834
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0025 0.0173 0.1474
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0262 0.0634
Schistosoma mansoni cpg binding protein 0.0026 0.0183 0.021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.017 0.0412
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0269 0.0269
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0254 0.0662
Loa Loa (eye worm) hypothetical protein 0.0024 0.0164 0.0397
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0028 0.0212 0.181
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0269 0.0269
Brugia malayi CHE-14 protein 0.0036 0.0333 0.0806
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0269 0.0308
Trichomonas vaginalis Heterochromatin protein, putative 0.0019 0.0088 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0429 0.1037
Schistosoma mansoni hypothetical protein 0.003 0.0254 0.0291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0269 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Brugia malayi G protein-coupled receptor 0.0031 0.0269 0.065
Brugia malayi hypothetical protein 0.003 0.0254 0.0615
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0266 0.2275
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0254 0.0291
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0031 0.0266 0.0642
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0018 0.0074 0.0179
Echinococcus multilocularis snurportin 1 0.0261 0.3673 0.3673
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0269 0.0308
Echinococcus granulosus neuropeptide receptor A26 0.0421 0.6055 0.6941
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0092 0.1169 0.276
Echinococcus granulosus g protein coupled receptor 0.0031 0.0269 0.0308
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0266 0.2275
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Echinococcus granulosus 6 phosphofructokinase 0.0092 0.1169 0.134
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0537 0.0537
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.023 0.0557
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0048 0.0117
Brugia malayi glutathione reductase 0.0072 0.0872 0.211
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0269 0.065
Plasmodium falciparum transporter, putative 0.005 0.0537 0.6157
Brugia malayi Isocitrate dehydrogenase 0.0013 0 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0038 0.0324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0105 0.0895
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0043 0.0049
Schistosoma mansoni histamine h1 receptor 0.0031 0.0269 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Loa Loa (eye worm) 6-phosphofructokinase 0.0092 0.1169 0.2827
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0269 0.0269
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0419 0.115
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0164 0.1403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2965 0.7172
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0269 0.0308
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0088 0.0169
Plasmodium falciparum glutathione reductase 0.0072 0.0872 1
Onchocerca volvulus 0.0031 0.0269 0.0578
Brugia malayi neuropeptide F receptor 0.0031 0.0269 0.065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Brugia malayi Serotonin receptor 0.0031 0.0269 0.065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0367 0.0887
Schistosoma mansoni opsin-like receptor 0.0031 0.0269 0.0308
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0367 0.3137
Brugia malayi jmjC domain containing protein 0.002 0.0105 0.0254
Echinococcus multilocularis survival motor neuron protein 1 0.02 0.2776 0.2776
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0402 0.0972
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0043 0.0049
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0076 0.0932 0.0932
Echinococcus multilocularis flap endonuclease 1 0.0022 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0016 0.0043 0.0099
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0043 0.0049
Brugia malayi hypothetical protein 0.0016 0.0043 0.0103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0269 0.0269
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.0235 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus multilocularis lamin 0.0031 0.0262 0.0262
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0537 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0107 0.0224
Loa Loa (eye worm) hypothetical protein 0.0204 0.2833 0.6854
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0109 0.0928
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0105 0.012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0173 0.5895
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0269 0.0308
Trichomonas vaginalis mercuric reductase, putative 0.0025 0.0173 0.0419
Brugia malayi follicle stimulating hormone receptor 0.0226 0.3162 0.7648
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0069 0.0432
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0215 0.0247
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0254 0.0616
Mycobacterium ulcerans hypothetical protein 0.0031 0.0254 0.1913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0402 0.046
Onchocerca volvulus 0.0031 0.0269 0.0578
Toxoplasma gondii hypothetical protein 0.005 0.0537 0.6157
Schistosoma mansoni myosin xvIII 0.0031 0.0269 0.0308
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0085 0.1059 0.1214
Echinococcus multilocularis geminin 0.0144 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0269 0.0269
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.009 0.0457
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0088 0.0169
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0308 0.0353
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0028 0.0212 0.181
Loa Loa (eye worm) RNA binding protein 0.0054 0.0598 0.1447
Schistosoma mansoni lamin 0.0031 0.0262 0.03
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0269 0.0308
Plasmodium vivax thioredoxin reductase, putative 0.0072 0.0872 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0367 0.0887
Brugia malayi hypothetical protein 0.0096 0.122 0.2952
Plasmodium vivax importin-beta 2, putative 0.0024 0.0164 0.1881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0106 0.0222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0262 0.3003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0269 0.0269
Leishmania major importin beta-1 subunit, putative 0.002 0.0096 0.0816
Onchocerca volvulus 0.0031 0.0269 0.0578
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0119 0.1357
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0088 0.0501
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0207 0.2879 0.3301
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus multilocularis transfer RNA-Lys 0.0031 0.0254 0.0254
Plasmodium vivax hypothetical protein, conserved 0.005 0.0537 0.6157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0254 0.2175
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0016 0.0043 0.0033
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0025 0.0173 0.1976
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0132 0.0299
Echinococcus multilocularis cpg binding protein 0.0026 0.0183 0.0183
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0537 0.1299
Schistosoma mansoni opsin-like receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) inositol-1 0.0031 0.0266 0.0644
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0402 0.046
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.0173 0.0198
Brugia malayi Dopamine receptor protein 2 0.0031 0.0269 0.065
Brugia malayi Niemann-Pick C1 protein precursor 0.0083 0.104 0.2515
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0049 0.0523 0.1265
Toxoplasma gondii histone lysine methyltransferase SET1 0.0047 0.0503 0.5761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0165 0.2243 0.8325
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0096 0.0191
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0031 0.0076
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0537 0.0616
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0537 0.0616
Echinococcus granulosus fmrfamide receptor 0.0031 0.0269 0.0308
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0028 0.0212 0.181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.017 0.0412
Schistosoma mansoni biogenic amine receptor 0.0031 0.0269 0.0308
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0109 0.1413 0.3417
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0092 0.1169 0.4139
Loa Loa (eye worm) hypothetical protein 0.0096 0.1219 0.2948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0136 0.031
Echinococcus granulosus lamin 0.0031 0.0262 0.03
Loa Loa (eye worm) CHromoDomain protein family member 0.0021 0.0109 0.0264
Toxoplasma gondii thioredoxin reductase 0.0072 0.0872 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0741 0.0741
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.1299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni ap endonuclease 0.0016 0.0038 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0132 0.0299
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0164 0.0164
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0047 0.0496 0.0569
Echinococcus granulosus flap endonuclease 1 0.0022 0.0129 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0088 0.1011
Loa Loa (eye worm) hypothetical protein 0.0063 0.0741 0.1793
Toxoplasma gondii hypothetical protein 0.005 0.0537 0.6157
Echinococcus multilocularis Chromobox protein 3 0.0019 0.0088 0.0088
Loa Loa (eye worm) doublecortin family protein 0.0017 0.005 0.012
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0259 0.3649 0.8827
Brugia malayi Valyl-tRNA synthetase 0.0019 0.0088 0.0214
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0043 0.0043
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0043 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.0031 0.0269 0.0308
Schistosoma mansoni ap endonuclease 0.0016 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0043 0.0049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Trichomonas vaginalis ran, putative 0.0018 0.0069 0.011
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0254 0.0943
Echinococcus granulosus serotonin receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0269 0.065
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0062 0.0728 0.0728
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0269 0.0308
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0038 0.0324
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0076 0.0932 0.1068
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0269 0.0308
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0408 0.0988
Trichomonas vaginalis importin beta-1, putative 0.002 0.0096 0.0191
Brugia malayi ORL1-like opioid receptor 0.0031 0.0269 0.065
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0269 0.065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0269 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Brugia malayi SET domain containing protein 0.0021 0.0113 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0254 0.0662
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.096 0.2321
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0096 0.0816
Brugia malayi MH2 domain containing protein 0.0101 0.1303 0.3152
Echinococcus granulosus chromobox protein 1 0.0069 0.0821 0.0942
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0269 0.0308
Schistosoma mansoni hypothetical protein 0.0144 0.1933 0.2216
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0238 0.0272
Schistosoma mansoni rab6-interacting 0.0017 0.005 0.0057
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) transcription factor SMAD2 0.0101 0.1303 0.3152
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0741 0.85
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0314 0.036
Loa Loa (eye worm) phosphofructokinase 0.0092 0.1169 0.2827
Brugia malayi hypothetical protein 0.02 0.2776 0.6715
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0266 0.2017
Brugia malayi AF-10 protein 0.0021 0.0109 0.0263
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0021 0.0109 0.0125
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0254 0.0292
Echinococcus multilocularis neuropeptide receptor 0.0601 0.8723 0.8723
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Loa Loa (eye worm) hypothetical protein 0.0055 0.0615 0.1487
Entamoeba histolytica hypothetical protein 0.0016 0.0043 0.0099
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0024 0.0027
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0057
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0269 0.0269
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0025 0.0171 0.0414
Brugia malayi Associated with TFs and helicases family protein 0.0019 0.0088 0.0214
Echinococcus multilocularis Regulator of G protein signaling 20 0.0016 0.0043 0.0043
Schistosoma mansoni inositol monophosphatase 0.0031 0.0266 0.0305
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0043 0.0049
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0049 0.0523 0.06
Loa Loa (eye worm) hypoxia-induced factor 1 0.0128 0.1695 0.4101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0254 0.0943
Onchocerca volvulus 0.0031 0.0262 0.0562
Schistosoma mansoni neuropeptide receptor 0.0031 0.0269 0.0308
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0269 0.0269
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0165 0.2243 0.8325
Onchocerca volvulus 0.005 0.0537 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0251 0.0652
Mycobacterium tuberculosis Probable reductase 0.0165 0.2243 0.8325
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0025 0.0173 0.1189
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0269 0.0308
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0565 0.0648
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0269 0.0308
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0105 0.012
Onchocerca volvulus 0.0031 0.0269 0.0578
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0565 0.4663
Loa Loa (eye worm) TAR-binding protein 0.0054 0.0598 0.1447
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0269 0.0269
Echinococcus multilocularis expressed protein 0.0028 0.0222 0.0222
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0092 0.1169 1
Schistosoma mansoni ran 0.0018 0.0069 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0043 0.0049
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0025 0.0171 0.1957
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0019 0.0088 0.0101
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0088 0.0501
Mycobacterium ulcerans beta-lactamase 0.0031 0.0254 0.1913
Brugia malayi PHD-finger family protein 0.0063 0.0741 0.1793
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0537 0.0616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Loa Loa (eye worm) hypothetical protein 0.0043 0.0436 0.1055
Schistosoma mansoni chromobox protein 0.0019 0.0088 0.0101
Echinococcus multilocularis peregrin 0.0063 0.0741 0.0741
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0043 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0821 0.2344
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0598 0.0686
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0269 0.0308
Echinococcus multilocularis tumor protein p63 0.0286 0.4051 0.4051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Brugia malayi hypothetical protein 0.0138 0.1854 0.4486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0523 0.429
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0018 0.0074 0.0179
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0043 0.0103
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0367 0.0367
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.0129 0.1478
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0105 0.0895
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0565 0.0648
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.0173 0.1474
Schistosoma mansoni chromobox protein 0.0069 0.0821 0.0942
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Plasmodium falciparum flap endonuclease 1 0.0022 0.0129 0.1478
Schistosoma mansoni hypothetical protein 0.0035 0.0314 0.036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0163 0.0394
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0537 0.0537
Brugia malayi Cytochrome P450 family protein 0.0044 0.046 0.1112
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0021 0.0109 0.0109
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0036 0.0333 0.0806
Trichomonas vaginalis hypothetical protein 0.0019 0.0088 0.0169
Schistosoma mansoni 6-phosphofructokinase 0.0092 0.1169 0.134
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.011 0.143 0.3461
Brugia malayi chromobox protein homolog 3 0.0043 0.0436 0.1055
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0269 0.0269
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0019 0.0088 0.1011
Schistosoma mansoni flap endonuclease-1 0.002 0.0098 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0038 0.0434
Echinococcus multilocularis protein patched 0.0036 0.0333 0.0333
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0049 0.0523 0.4475
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0269 0.065
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Echinococcus multilocularis microtubule associated protein 2 0.0585 0.848 0.848
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0419 0.115
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0088 0.1011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0367 0.3137
Leishmania major GTP-binding protein, putative 0.0018 0.0069 0.0584
Brugia malayi hypothetical protein 0.0014 0.0006 0.0015
Schistosoma mansoni patched 1 0.0036 0.0333 0.0382
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0236 0.057
Brugia malayi PAS domain containing protein 0.0041 0.0413 0.1
Brugia malayi Protein cec-1. 0.0019 0.0088 0.0214
Schistosoma mansoni aryl hydrocarbon receptor 0.0041 0.0413 0.0474
Loa Loa (eye worm) hypothetical protein 0.0292 0.4134 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0107 0.0224
Loa Loa (eye worm) hypothetical protein 0.0042 0.0429 0.1037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0043 0.0049
Entamoeba histolytica hypothetical protein 0.0019 0.0088 0.0501
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.6157
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0217 0.0806
Onchocerca volvulus 0.0108 0.141 0.3361
Loa Loa (eye worm) RGS-3 protein 0.0016 0.0043 0.0103
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0269 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0181 0.0443
Loa Loa (eye worm) hypothetical protein 0.0292 0.4134 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0149 0.035
Echinococcus granulosus expressed conserved protein 0.0078 0.0965 0.1106
Schistosoma mansoni phd/f-box containing protein 0.002 0.0105 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0419 0.115
Echinococcus granulosus tar DNA binding protein 0.0054 0.0598 0.0686
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0269 0.0269
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0402 0.0972
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.096 0.11
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0269 0.0308
Brugia malayi PXA domain containing protein 0.0016 0.0043 0.0103
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2583 0.2583
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus Regulator of G protein signaling 20 0.0016 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0436 0.1201
Brugia malayi jmjC domain containing protein 0.002 0.0105 0.0254
Plasmodium vivax glutathione reductase, putative 0.0072 0.0872 1
Loa Loa (eye worm) hypothetical protein 0.02 0.2776 0.6715
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0105 0.12
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0043 0.0049
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.003 0.0252 0.2151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0269 0.0308
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Brugia malayi phosphofructokinase 0.0092 0.1169 0.2827
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.0129 0.1478
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0269 0.065
Brugia malayi RE15519p 0.0031 0.0269 0.065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0419 0.115
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0254
Echinococcus granulosus g protein coupled receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.1742 0.4214
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0419 0.0419
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.1109 0.1109
Brugia malayi Pre-SET motif family protein 0.0213 0.2965 0.7172
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.009 0.0766
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0105 0.0105
Brugia malayi beta-lactamase family protein 0.0031 0.0254 0.0616
Onchocerca volvulus 0.0096 0.1219 0.2894
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0537 0.0537
Giardia lamblia GTOR 0.0038 0.0367 0.4674
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0269 0.065
Trichomonas vaginalis phosphofructokinase, putative 0.0092 0.1169 0.3375
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Brugia malayi Dopamine receptor 0.0031 0.0269 0.065
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0262 0.0262
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.4134 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0452
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.6157
Echinococcus multilocularis musashi 0.0031 0.0262 0.0262
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0537 0.0537
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0119 0.1013
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0537 0.0616
Brugia malayi hypothetical protein 0.0103 0.1333 0.3224
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0419 0.115
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0183 0.2516 1
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0105 0.012
Mycobacterium ulcerans lipase LipD 0.0031 0.0254 0.1913
Onchocerca volvulus 0.0031 0.0269 0.0578
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0269 0.0308
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0254 0.0291
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0076 0.0932 0.1068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Schistosoma mansoni amine GPCR 0.0031 0.0269 0.0308
Echinococcus granulosus lamin dm0 0.0031 0.0262 0.03
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0105 0.012
Onchocerca volvulus Alhambra homolog 0.0063 0.0741 0.173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0038 0.014
Echinococcus multilocularis expressed protein 0.0316 0.4496 0.4496
Brugia malayi putative neuropeptide receptor 0.0031 0.0269 0.065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0016 0.0036 0.0309
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.005 0.005
Schistosoma mansoni amine GPCR 0.0031 0.0269 0.0308
Plasmodium vivax heterochromatin protein 1, putative 0.0019 0.0088 0.1011
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0021 0.0109 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0939 0.0939
Onchocerca volvulus 0.0031 0.0262 0.0562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0251 0.0652
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0214
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0016 0.0043 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Echinococcus multilocularis sterol regulatory element binding protein 0.0036 0.0333 0.0333
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0269 0.065
Leishmania major ATP-dependent phosphofructokinase 0.0092 0.1169 1
Leishmania major trypanothione reductase 0.0072 0.0872 0.7461
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.046 0.1112
Echinococcus granulosus Protein patched homolog 1 0.0036 0.0333 0.0382
Onchocerca volvulus 0.0031 0.0269 0.0578
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0402 0.046
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0821 0.2344
Echinococcus multilocularis lamin dm0 0.0031 0.0262 0.0262
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0269 0.065
Schistosoma mansoni hypothetical protein 0.0031 0.0269 0.0308
Echinococcus multilocularis beta adrenergic receptor kinase 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0069 0.0584
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Loa Loa (eye worm) beta-lactamase 0.0031 0.0254 0.0616
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0088 0.0169
Loa Loa (eye worm) hypothetical protein 0.0096 0.122 0.2952
Treponema pallidum NADH oxidase 0.0025 0.0173 0.0328
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni alpha-glucosidase 0.0161 0.2195 0.2517
Schistosoma mansoni ran 0.0018 0.0069 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0254
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0266 0.0697
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0269 0.0308
Onchocerca volvulus 0.0031 0.0269 0.0578
Schistosoma mansoni hypothetical protein 0.0041 0.0408 0.0468
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0269 0.0578
Echinococcus multilocularis serotonin transporter 0.0292 0.4134 0.4134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0038 0.002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0024 0.0024
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0043 0.0103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0269 0.065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.2583 0.6248
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0043 0.0049
Brugia malayi Cytochrome P450 family protein 0.0019 0.009 0.0217
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.1299
Loa Loa (eye worm) hypothetical protein 0.0083 0.104 0.2515
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0025 0.0171 0.1889
Schistosoma mansoni hypothetical protein 0.0031 0.0269 0.0308
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0419 0.115
Echinococcus granulosus survival motor neuron protein 1 0.02 0.2776 0.3182
Echinococcus multilocularis chromobox protein 1 0.0069 0.0821 0.0821
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0076 0.0932 0.1068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0254 0.0292
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0048 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0251 0.0652
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0025 0.0171 0.1226
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0269 0.065
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0025 0.0173 0.1474
Echinococcus granulosus beta-adrenergic receptor kinase 0.0016 0.0043 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0269 0.0269
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0269 0.0308
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0016 0.0043 0.0049
Onchocerca volvulus 0.005 0.0549 0.1261
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0043 0.0049
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0537 0.0616
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.0173 0.0173
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0262 0.0634
Onchocerca volvulus 0.0243 0.3402 0.8216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0169 0.0407
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0044 0.0452 0.0518
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0088 0.0501
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0043 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0149 0.035
Loa Loa (eye worm) helicase 0.0019 0.0088 0.0214
Leishmania major protein kinase, putative 0.0015 0.0022 0.0185
Trichomonas vaginalis rotamase, putative 0.0028 0.0212 0.0535
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0269 0.0269
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Onchocerca volvulus 0.0031 0.0254 0.0544
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.1303 0.3152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0474 0.1078
Toxoplasma gondii ABC1 family protein 0.0031 0.0254 0.2915
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0266 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0269 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Echinococcus granulosus peregrin 0.0063 0.0741 0.085
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0043 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0333 0.0806
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0019 0.0088 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0214
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0019 0.0088 0.1011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0269 0.0308
Echinococcus granulosus jumonji domain containing protein 0.0088 0.1109 0.1272
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) glutathione reductase 0.0072 0.0872 0.211
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0254 0.0662
Trichomonas vaginalis phosphofructokinase, putative 0.0092 0.1169 0.3375
Plasmodium vivax amine transporter, putative 0.005 0.0537 0.6157
Onchocerca volvulus 0.0031 0.0254 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0419 0.3581
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.0129 0.1103
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0475 0.1148
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0367 0.0421
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0105 0.012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0054 0.0598 0.1447
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0254 0.2915
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0019 0.0088 0.0088
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0025 0.0173 0.0417
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni lamin 0.0031 0.0262 0.03
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0262 0.0634
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0038 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0214
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0164 0.1403
Onchocerca volvulus 0.0026 0.0187 0.0378
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0254 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Schistosoma mansoni hypothetical protein 0.0019 0.0088 0.0101
Schistosoma mansoni amine GPCR 0.0031 0.0269 0.0308
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0016 0.0043 0.0043
Brugia malayi G-protein coupled receptor 0.0031 0.0269 0.065
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0119 0.1357
Onchocerca volvulus 0.0031 0.0254 0.0544
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0038 0.0434
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0367 0.2949
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0367 0.3137
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0254 0.1913
Schistosoma mansoni hypothetical protein 0.0035 0.0314 0.036
Brugia malayi jmjC domain containing protein 0.002 0.0105 0.0254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0204 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0088 0.0169
Brugia malayi Dopamine receptor protein 1 0.0031 0.0269 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0269 0.3791 0.9172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0266 0.2275
Brugia malayi PHD-finger family protein 0.0022 0.0129 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0402 0.046
Schistosoma mansoni protein phosphatase 2C 0.002 0.0105 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0436 0.1201
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0107 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Echinococcus multilocularis protein dispatched 1 0.0041 0.0408 0.0408
Schistosoma mansoni 6-phosphofructokinase 0.0092 0.1169 0.134
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0069 0.0587
Echinococcus granulosus chromobox protein 1 0.0069 0.0821 0.0942
Schistosoma mansoni hypothetical protein 0.0347 0.4946 0.567
Brugia malayi intermediate filament protein 0.0031 0.0262 0.0634
Echinococcus multilocularis chromobox protein 2 0.0019 0.0088 0.0088
Onchocerca volvulus 0.0024 0.0163 0.032
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0269 0.0269
Echinococcus granulosus microtubule associated protein 2 0.0585 0.848 0.9722
Trypanosoma cruzi target of rapamycin kinase 3 0.003 0.0252 0.2151
Brugia malayi hypoxia-induced factor 1 0.0128 0.1695 0.4101
Echinococcus granulosus neuropeptide s receptor 0.0421 0.6055 0.6941
Schistosoma mansoni chromobox protein 0.0069 0.0821 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0367 0.0995
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0019 0.0088 0.0214
Brugia malayi sulfakinin receptor protein 0.0031 0.0269 0.065
Schistosoma mansoni cpg binding protein 0.0026 0.0183 0.021
Plasmodium vivax JmjC domain containing protein 0.002 0.0105 0.12
Brugia malayi M-phase phosphoprotein, mpp8 0.0096 0.1219 0.2948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Schistosoma mansoni neuropeptide receptor 0.0601 0.8723 1
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0741 0.85
Schistosoma mansoni alpha-glucosidase 0.0161 0.2195 0.2517
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0025 0.0173 0.1474
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0741 0.1793
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0025 0.0171 0.0324
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0025 0.0173 0.1976
Schistosoma mansoni microtubule-associated protein tau 0.0585 0.848 0.9722
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0038 0.0092
Echinococcus multilocularis sex peptide receptor 0.0031 0.0269 0.0269
Echinococcus granulosus Chromobox protein 3 0.0019 0.0088 0.0101
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0429 0.1037
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0092 0.1169 0.4336
Echinococcus multilocularis tar DNA binding protein 0.0054 0.0598 0.0598
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0119 0.1013
Onchocerca volvulus 0.0031 0.0269 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0251 0.0652
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0269 0.065
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.096 0.11
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0043 0.0043
Echinococcus multilocularis chromobox protein 1 0.0069 0.0821 0.0821
Trichomonas vaginalis esterase, putative 0.0031 0.0254 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0139 0.032
Echinococcus granulosus sex peptide receptor 0.0031 0.0269 0.0308
Onchocerca volvulus 0.0031 0.0269 0.0578
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0537 0.0616
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0195 0.2695 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0557
Onchocerca volvulus 0.0041 0.0408 0.0918
Schistosoma mansoni lipoxygenase 0.0047 0.0496 0.0569
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0262 0.0634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0598 0.0686
Echinococcus multilocularis G protein coupled receptor 139 0.0601 0.8723 0.8723
Brugia malayi Melatonin receptor type 1A 0.0031 0.0269 0.065
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0269 0.0308
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0254 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0139 0.032
Toxoplasma gondii 6-phosphofructokinase 0.0025 0.0171 0.1957
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0367 0.0421
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0019 0.0088 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0421 0.6055 0.6055
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0105 0.0254
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0266 0.2275
Echinococcus multilocularis serotonin receptor 0.0031 0.0269 0.0269
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0119 0.1357
Plasmodium vivax multidomain scavenger receptor, putative 0.0017 0.005 0.0565
Echinococcus granulosus tumor protein p63 0.0286 0.4051 0.4645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0106 0.0222
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0088 0.1011
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1571 0.1801
Schistosoma mansoni hypothetical protein 0.0261 0.3673 0.4211
Onchocerca volvulus 0.0031 0.0269 0.0578
Echinococcus granulosus cpg binding protein 0.0026 0.0183 0.021
Schistosoma mansoni rotamase 0.0028 0.0222 0.0254
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0419 0.1013
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0269 0.065
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.1299
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.0129 0.1103
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0565 0.0565
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0269 0.0269
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.0129 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0367 0.0995
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.4134 0.4739
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0269 0.0308
Brugia malayi jmjC domain containing protein 0.002 0.0105 0.0254
Echinococcus granulosus orexin receptor type 2 0.0031 0.0269 0.0308
Onchocerca volvulus 0.0017 0.005 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0537 0.0616
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0565 0.0648
Entamoeba histolytica Flap nuclease, putative 0.0022 0.0129 0.0859
Echinococcus multilocularis Polycystic kidney disease protein 0.0017 0.005 0.005
Brugia malayi RNA binding protein 0.0054 0.0598 0.1447
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0419 0.3581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0103
Schistosoma mansoni amine GPCR 0.0031 0.0269 0.0308
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0105 0.12
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0474 0.1312
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.0222 0.2543
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.2583 0.6248
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0308 0.0353
Schistosoma mansoni importin beta-1 0.0024 0.0164 0.0188
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0095 0.1205 0.1381
Brugia malayi Cytochrome P450 family protein 0.0019 0.009 0.0217
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0088 0.0169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0038 0.0324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.0173 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0136 0.031
Entamoeba histolytica phosphofructokinase, putative 0.0092 0.1169 1
Echinococcus granulosus Chromo domain 0.0019 0.0088 0.0101
Schistosoma mansoni chromobox protein 0.0019 0.0088 0.0101
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0269 0.0308
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0269 0.0269
Leishmania major hypothetical protein, conserved 0.0021 0.0119 0.1013
Giardia lamblia PHD finger protein 15 0.0063 0.0741 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0269 0.0578
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0105 0.0254
Onchocerca volvulus 0.0031 0.0269 0.0578
Echinococcus granulosus expressed protein 0.0316 0.4496 0.5154
Echinococcus granulosus geminin 0.0144 0.1933 0.2216
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0254 0.0943
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0266 0.3049
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0402 0.046
Toxoplasma gondii NADPH-glutathione reductase 0.0025 0.0173 0.1976
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0269 0.0269
Onchocerca volvulus 0.005 0.0537 0.1232
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0254 0.0662
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Plasmodium falciparum thioredoxin reductase 0.0025 0.0173 0.1976
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0269 0.065
Loa Loa (eye worm) serotonin transporter b 0.0292 0.4134 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0402 0.0402
Schistosoma mansoni hypothetical protein 0.0031 0.0269 0.0308
Echinococcus granulosus phd:f box containing protein 0.002 0.0105 0.012
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0025 0.0173 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0284 0.075
Echinococcus granulosus thioredoxin glutathione reductase 0.0073 0.0878 0.1007
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0269 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Mycobacterium tuberculosis Probable dehydrogenase 0.0165 0.2243 0.8325
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0254 0.0943
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0266 0.0697
Brugia malayi Bromodomain containing protein 0.0063 0.0741 0.1793
Echinococcus multilocularis 6 phosphofructokinase 0.0092 0.1169 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Leishmania major hypothetical protein, conserved 0.0031 0.0254 0.2175
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0367 0.3137
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0254 0.0943
Loa Loa (eye worm) 6-phosphofructokinase 0.0092 0.1169 0.2827
Entamoeba histolytica hypothetical protein 0.0016 0.0043 0.0099
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0269 0.0308
Echinococcus multilocularis regulator of G protein signaling 0.0016 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0072 0.0872 0.3235
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0038 0.0044
Schistosoma mansoni hypothetical protein 0.0035 0.0314 0.036
Schistosoma mansoni jumonji domain containing protein 0.0165 0.2247 0.2576
Brugia malayi Serotonin receptor 0.0031 0.0269 0.065
Brugia malayi Thioredoxin reductase 0.0072 0.0872 0.211
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0016 0.0043 0.0103
Echinococcus granulosus sterol regulatory element binding protein 0.0036 0.0333 0.0382
Trichomonas vaginalis phosphofructokinase, putative 0.0092 0.1169 0.3375
Echinococcus granulosus hypothetical protein 0.0031 0.0269 0.0308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0138 0.1854 0.4486
Schistosoma mansoni cpg binding protein 0.0024 0.0163 0.0187
Echinococcus granulosus g protein coupled receptor 0.0031 0.0269 0.0308
Entamoeba histolytica hypothetical protein 0.003 0.0254 0.1958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0262 0.03
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0537 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0088 0.0169
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0424 0.0486
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0419 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0333 0.0895
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0043 0.0049
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0537 0.6157
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0043 0.0049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.0235 0.0604
Brugia malayi GnHR receptor homolog 0.0031 0.0269 0.065
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Brugia malayi A-kinase anchor protein 10, precursor 0.0016 0.0043 0.0103
Brugia malayi beta-lactamase 0.0031 0.0254 0.0616
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0092 0.1169 1
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0269 0.0308
Echinococcus multilocularis somatostatin receptor 0.0031 0.0269 0.0269
Onchocerca volvulus 0.0031 0.0269 0.0578
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0105 0.0254
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0164 0.1881
Echinococcus multilocularis thioredoxin glutathione reductase 0.0073 0.0878 0.0878
Brugia malayi Heterochromatin protein 1 0.0069 0.0821 0.1987
Plasmodium falciparum glutathione reductase 0.0025 0.0173 0.1976
Mycobacterium leprae Probable lipase LipE 0.0031 0.0254 0.0161
Onchocerca volvulus 0.0031 0.0269 0.0578
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0267
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0131 0.1496
Brugia malayi CXXC zinc finger family protein 0.0024 0.0163 0.0394
Leishmania major cytochrome p450-like protein 0.0019 0.009 0.0766
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0031 0.0267
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0049 0.0523 0.06
Brugia malayi hypothetical protein 0.0016 0.0043 0.0103
Brugia malayi jmjC domain containing protein 0.0207 0.2879 0.6965
Echinococcus multilocularis dnaJ subfamily B 0.0347 0.4946 0.4946
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0261 0.3673 0.8885
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0598 0.0686
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0565 0.6481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Plasmodium falciparum phd finger protein, putative 0.0063 0.0741 0.85
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.0173 0.5895
Schistosoma mansoni hypothetical protein 0.0144 0.1933 0.2216
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0069 0.0584
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0254 0.0943
Mycobacterium tuberculosis Probable oxidoreductase 0.0183 0.2516 0.9337
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Brugia malayi regulator of G-protein signaling rgs-7 0.0016 0.0043 0.0103
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0028 0.0212 0.181
Echinococcus granulosus allatostatin A receptor 0.0031 0.0269 0.0308
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0183 0.2516 0.9337
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0038 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Schistosoma mansoni survival motor neuron protein 0.0041 0.0408 0.0468
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0269 0.0308
Echinococcus multilocularis serotonin receptor 0.0031 0.0269 0.0269
Brugia malayi neuropeptide F receptor 0.0031 0.0269 0.065
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0269 0.0308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0269 0.0308
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0269 0.0308
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0266 0.0266
Schistosoma mansoni loxhd1 0.0017 0.005 0.0057
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.012
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0269 0.065
Echinococcus granulosus Niemann Pick C1 protein 0.0083 0.104 0.1192
Trichomonas vaginalis phosphofructokinase, putative 0.0092 0.1169 0.3375
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0537 0.0616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0214
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0741 0.085
Schistosoma mansoni neuropeptide receptor 0.0031 0.0269 0.0308
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0031 0.0266 0.0642
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0171 0.1957
Mycobacterium tuberculosis Conserved protein 0.0031 0.0254 0.0943
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0419 0.3406
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0269 0.0269
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0429 0.1037
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0537 1
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0043 0.0049
Mycobacterium ulcerans 6-phosphofructokinase 0.0092 0.1169 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0565 0.2097
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0019 0.0088 0.1011
Schistosoma mansoni biogenic amine receptor 0.0031 0.0269 0.0308
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0537 0.0616
Loa Loa (eye worm) thioredoxin reductase 0.0072 0.0872 0.211
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0043 0.0043
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.4134 0.4739
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0262 0.0262
Onchocerca volvulus 0.0017 0.005 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Entamoeba histolytica hypothetical protein 0.0019 0.0088 0.0501
Brugia malayi hypothetical protein 0.0031 0.0269 0.065
Trypanosoma brucei trypanothione reductase 0.0072 0.0872 0.7461
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0741 0.085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Loa Loa (eye worm) PXA domain-containing protein 0.0016 0.0043 0.0103
Brugia malayi isocitrate dehydrogenase 0.0013 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0565 0.4663
Brugia malayi RNA recognition motif domain containing protein 0.0054 0.0598 0.1447
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0821 0.1987
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0214
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.009 0.0217
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.0266 0.0266
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.3162 0.7648
Plasmodium falciparum amino acid transporter, putative 0.005 0.0537 0.6157
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0367 0.2949
Brugia malayi 6-phosphofructokinase 0.0092 0.1169 0.2827
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0028 0.0222 0.0536
Brugia malayi hypothetical protein 0.0021 0.0119 0.0287
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0269 0.0269
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0119 0.1013
Echinococcus granulosus somatostatin receptor 0.0031 0.0269 0.0308
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0419 0.48
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.4134 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0262 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3401 1
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0269 0.065
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0019 0.0088 0.1011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0269 0.065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0269 0.0269
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0269 0.065
Schistosoma mansoni adenoreceptor 0.0031 0.0269 0.0308
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0436 0.0987
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0126 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0549 0.0629
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0269 0.0269
Echinococcus granulosus expressed protein 0.0028 0.0222 0.0254
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0047 0.0496 0.0496
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0269 0.0308
Schistosoma mansoni inositol monophosphatase 0.0031 0.0266 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0254 0.2175
Onchocerca volvulus 0.0031 0.0269 0.0578
Schistosoma mansoni intermediate filament proteins 0.0031 0.0262 0.03
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0083 0.104 0.8867
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0049 0.0523 0.0523
Brugia malayi G-protein coupled receptor 0.0031 0.0269 0.065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Schistosoma mansoni hypothetical protein 0.0063 0.0741 0.085
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0269 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0254 0.1913
Brugia malayi TAR-binding protein 0.0054 0.0598 0.1447
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0107 0.0224
Echinococcus multilocularis RUN 0.0017 0.005 0.005
Schistosoma mansoni single-minded 0.0041 0.0413 0.0474
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0171 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0269 0.0308
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0173 0.1474
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0042 0.0424 0.1025
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0129 0.029
Trypanosoma brucei cytochrome P450, putative 0.0019 0.009 0.0766
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0183 0.2516 0.9337
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0025 0.0173 0.0044
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.005 0.0057
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0266 0.0697
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0043 0.0049
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0266 0.2064
Echinococcus multilocularis Niemann Pick C1 protein 0.0083 0.104 0.104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.096 0.11
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0109 0.1244
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0038 0.0324
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.005 0.0057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0266 1
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Brugia malayi Doublecortin family protein 0.0017 0.005 0.012
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0043 0.0043
Schistosoma mansoni lipoxygenase 0.0017 0.005 0.0057
Echinococcus granulosus snurportin 1 0.0261 0.3673 0.4211
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0131 0.1496
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0584 0.067
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0419 0.3406
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.4134 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0049 0.0523 0.194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0222 0.0565
Brugia malayi larval opioid receptor 0.0031 0.0269 0.065
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0171 0.1957
Plasmodium falciparum thioredoxin reductase 0.0072 0.0872 1
Echinococcus granulosus single minded 2 0.0033 0.0297 0.0341
Plasmodium falciparum LCCL domain-containing protein 0.0017 0.005 0.0565
Plasmodium vivax SET domain protein, putative 0.0031 0.0262 0.3003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0171 0.1957
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0419 0.1013
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0171 0.1957
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.2583 0.2961
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0537 0.0616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0262 0.03
Onchocerca volvulus 0.0096 0.1219 0.2894
Giardia lamblia NADH oxidase lateral transfer candidate 0.0025 0.0173 0.1912
Entamoeba histolytica hypothetical protein 0.003 0.0254 0.1958
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0269 0.0269
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0069 0.0166
Brugia malayi 6-phosphofructokinase 0.0092 0.1169 0.2827
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0069 0.0782
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0367 0.3137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0367 0.0995
Schistosoma mansoni amine GPCR 0.0031 0.0269 0.0308
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0043 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0088 0.0101
Brugia malayi hypothetical protein 0.0017 0.005 0.012
Entamoeba histolytica phosphofructokinase, putative 0.0092 0.1169 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0254 0.0616
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0537 0.0616
Entamoeba histolytica hypothetical protein 0.002 0.0096 0.0565
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0565 0.4836
Echinococcus granulosus neuropeptide receptor 0.0601 0.8723 1
Brugia malayi AKH receptor 0.0031 0.0269 0.065
Mycobacterium tuberculosis Conserved protein 0.0031 0.0254 0.0943
Brugia malayi Pre-SET motif family protein 0.0031 0.0262 0.0634
Onchocerca volvulus 0.005 0.0537 0.1232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0262 0.0634
Brugia malayi PXA domain containing protein 0.0016 0.0043 0.0103
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0049 0.0523 0.429
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0565 0.4663
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.0266 0.0304
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0069 0.0782
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0043 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0254 0.0254
Brugia malayi Flap endonuclease-1 0.0022 0.0129 0.0312
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0069 0.0584
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0069 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.0173 0.1474
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0025 0.0173 0.1976
Echinococcus multilocularis expressed conserved protein 0.0078 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0025 0.0173 0.1976
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0025 0.0173 0.1189
Brugia malayi bHLH-PAS transcription factor 0.0031 0.0254 0.0616
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0038 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0269 0.0308
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0069 0.0166
Entamoeba histolytica hypothetical protein 0.003 0.0254 0.1958
Onchocerca volvulus 0.0292 0.4134 1
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0031 0.0267
Onchocerca volvulus 0.0031 0.0254 0.0544
Echinococcus multilocularis neuropeptide receptor A26 0.0421 0.6055 0.6055
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0165 0.2243 0.8325
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0419 0.115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0269 0.0308
Trypanosoma brucei target of rapamycin kinase 3, putative 0.003 0.0252 0.2151
Onchocerca volvulus 0.0031 0.0269 0.0578
Echinococcus granulosus chromobox protein 2 0.0019 0.0088 0.0101
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0269 0.065
Brugia malayi hypothetical protein 0.0017 0.005 0.012
Schistosoma mansoni polycystin 1-related 0.0017 0.005 0.0057
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0269 0.0269
Brugia malayi RNA, U transporter 1 0.007 0.0833 0.2015
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0537 0.0616
Loa Loa (eye worm) hypothetical protein 0.0292 0.4134 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.0109 0.0125
Mycobacterium ulcerans putative regulatory protein 0.0031 0.0254 0.1913
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Toxoplasma gondii peptidylprolyl isomerase 0.0028 0.0212 0.2426
Echinococcus granulosus Polycystic kidney disease protein 0.0017 0.005 0.0057
Entamoeba histolytica Ran family GTPase 0.0018 0.0069 0.0326
Entamoeba histolytica hypothetical protein 0.003 0.0254 0.1958
Schistosoma mansoni jumonji domain containing protein 0.002 0.0105 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.017 0.0412
Echinococcus multilocularis phd:f box containing protein 0.002 0.0105 0.0105
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0109 0.0928
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0028 0.0222 0.0536
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.009 0.0766
Onchocerca volvulus 0.0031 0.0269 0.0578
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0269 0.0269
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0025 0.0173 0.1976
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Onchocerca volvulus 0.0031 0.0269 0.0578
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.0129 0.1294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0126 0.0282
Toxoplasma gondii exonuclease III APE 0.0016 0.0038 0.0434
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0105 0.0895
Schistosoma mansoni rab6-interacting 0.0017 0.005 0.0057
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.0872 0.7461
Leishmania major hypothetical protein, conserved 0.002 0.0105 0.0895
Loa Loa (eye worm) hypothetical protein 0.0022 0.0129 0.0313
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0537 0.0616
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.0616
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0598 0.0686
Echinococcus granulosus serotonin transporter 0.0292 0.4134 0.4739
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Schistosoma mansoni hypothetical protein 0.0029 0.023 0.0264
Schistosoma mansoni alpha glucosidase 0.0042 0.0419 0.048
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0269 0.0269
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0105 0.12
Loa Loa (eye worm) hypothetical protein 0.005 0.0537 0.1299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0537 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1571 0.1571
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.4134 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0025 0.0173 0.1474
Echinococcus multilocularis Chromo domain 0.0019 0.0088 0.0088
Schistosoma mansoni biogenic amine receptor 0.0031 0.0269 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.0173 0.1474
Loa Loa (eye worm) hypothetical protein 0.0044 0.0453 0.1095
Trypanosoma brucei glucosidase, putative 0.0042 0.0419 0.3581
Brugia malayi Importin beta-1 subunit 0.0024 0.0164 0.0397
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0269 0.0308
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0025 0.0173 0.1189
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0119 0.1357
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0016 0.0043 0.0103
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0367 0.3137
Trichomonas vaginalis glutathione reductase, putative 0.0025 0.0173 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0251 0.0652
Onchocerca volvulus 0.0042 0.0424 0.0956
Echinococcus granulosus importin subunit beta 1 0.0024 0.0164 0.0188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0269 0.065
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0474 0.1312

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.33 nM Binding affinity towards Dopamine transporter by displacement of [3H]- WIN 35,428 radioligand from rat brain ChEMBL. 8411004
IC50 (binding) = 60 nM Binding affinity towards norepinephrine transporter by displacement of [3H]-nisoxatine radioligand from rat brain ChEMBL. 8411004
IC50 (binding) = 1070 nM Binding affinity towards serotonin transporter by displacement of [3H]- paroxetine radioligand from rat brain ChEMBL. 8411004
Ratio (binding) = 26 Ratio between norepinephrine and Dopamine transporter ChEMBL. 8411004
Ratio (binding) = 459 Ratio between serotonin transporter and Dopamine transporter ChEMBL. 8411004

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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