Detailed information for compound 165078

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 310.271 | Formula: C15H13F3N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.37 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc2c(c1)[C@](C#CC1CC1)(OC(=O)N2)C(F)(F)F
  • InChi: 1S/C15H13F3N2O2/c1-19-10-4-5-12-11(8-10)14(15(16,17)18,22-13(21)20-12)7-6-9-2-3-9/h4-5,8-9,19H,2-3H2,1H3,(H,20,21)/t14-/m0/s1
  • InChiKey: GKLDOEFIEUOYHQ-AWEZNQCLSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0693 0.076
Schistosoma mansoni hypothetical protein 0.0046 0.002 0.0015
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2459 1 1
Schistosoma mansoni hypothetical protein 0.0081 0.0167 0.0163
Schistosoma mansoni intermediate filament proteins 0.0135 0.0391 0.0387
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Giardia lamblia Hypothetical protein 0.0064 0.0098 0.0058
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0136 0.0114
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0237 0.0809 0.0791
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0207 0.0229
Loa Loa (eye worm) polyprenyl synthetase 0.1401 0.5624 0.6165
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Schistosoma mansoni glutathione synthetase 0.0412 0.1536 0.1532
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0412 0.1536 0.2695
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0252 0.04
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.05
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0395
Brugia malayi hypothetical protein 0.0102 0.0252 0.0362
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0064 0.0098 0.0125
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.0291 0.0272
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0412 0.1536 0.2695
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Echinococcus multilocularis transfer RNA-Ile 0.1223 0.4889 0.4879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Echinococcus multilocularis 0.0064 0.0098 0.0078
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0391 0.0429
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Brugia malayi Matrixin family protein 0.0211 0.0706 0.1096
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Trypanosoma cruzi target of rapamycin kinase 3 0.0097 0.0234 0.0333
Mycobacterium ulcerans thymidylate kinase 0.029 0.1031 0.1789
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Echinococcus multilocularis solute carrier family 28 0.0363 0.1331 0.1314
Echinococcus granulosus survival motor neuron protein 1 0.0954 0.3775 0.3763
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1218 0.4869 0.7811
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0361 0.0396
Brugia malayi Bromodomain containing protein 0.0075 0.0142 0.0184
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0139 0.0176
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Schistosoma mansoni hypothetical protein 0.0068 0.0114 0.011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0421 0.1574 0.25
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0095 0.0222 0.0203
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0278 0.0274
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0281 0.0995 0.0977
Brugia malayi hypothetical protein 0.0066 0.0103 0.0121
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Leishmania major thymidine kinase, putative 0.1019 0.4044 0.7177
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0064 0.0098 0.0113
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Chlamydia trachomatis thymidylate kinase 0.029 0.1031 0.4659
Schistosoma mansoni hypothetical protein 0.029 0.1031 0.1027
Loa Loa (eye worm) hypothetical protein 0.0064 0.0098 0.0107
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0139 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0095 0.0222 0.0244
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0412 0.1536 0.2695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.033 0.0362
Loa Loa (eye worm) hypothetical protein 0.0954 0.3775 0.4138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.007 0.0121 0.0116
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0057 0.0066 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.04 0.0439
Onchocerca volvulus Putative thymidylate kinase 0.029 0.1031 0.5857
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0486 0.1841 0.293
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Entamoeba histolytica protein kinase rad3, putative 0.007 0.0121 0.0147
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0167
Echinococcus multilocularis thymidylate kinase 0.029 0.1031 0.1013
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1401 0.5624 0.9039
Onchocerca volvulus 0.0057 0.0068 0.0017
Brugia malayi RNA binding protein 0.0128 0.0361 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0107 0.0272 0.0391
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0381 0.0362
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.0291 0.1367
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Toxoplasma gondii hypothetical protein 0.0141 0.0413 0.0688
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Schistosoma mansoni lipoxygenase 0.0055 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Echinococcus granulosus serine protein kinase ATM 0.007 0.0121 0.0101
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Entamoeba histolytica cytidine deaminase, putative 0.0057 0.0066 0.0057
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0236 0.0806 0.0884
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0274 0.0963 0.1509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0245 0.0351
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1401 0.5624 1
Echinococcus multilocularis cytidine deaminase 0.0057 0.0066 0.0046
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0412 0.1536 0.2435
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Loa Loa (eye worm) hypothetical protein 0.01 0.0245 0.0269
Loa Loa (eye worm) RNA binding protein 0.0128 0.0361 0.0396
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0028 0.0008
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0121 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0095 0.0222 0.0482
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0963 0.1459
Toxoplasma gondii thymidylate kinase 0.029 0.1031 0.1792
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1401 0.5624 1
Loa Loa (eye worm) runx1 0.0057 0.0067 0.0074
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1544 0.6215 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Loa Loa (eye worm) hypothetical protein 0.0811 0.3187 0.3493
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0106 0.0141
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0083 0.0174 0.0261
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0106 0.0278
Brugia malayi follicle stimulating hormone receptor 0.024 0.0823 0.1285
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.007 0.0121 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0026 0.0006
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Schistosoma mansoni hypothetical protein 0.0064 0.0098 0.0093
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0412 0.1536 0.2692
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0363 0.1331 0.1314
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0139 0.0198
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0236 0.0806 0.1259
Leishmania major polyprenyl synthase, putative 0.0573 0.2202 0.3886
Schistosoma mansoni carbonic anhydrase 0.0141 0.0413 0.0408
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0151
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Echinococcus multilocularis lamin 0.0135 0.0391 0.0372
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0163 0.0242
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0412 0.1536 0.2695
Schistosoma mansoni lozenge 0.0057 0.0067 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0125 0.0097
Onchocerca volvulus 0.0081 0.0167 0.0619
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1459
Plasmodium falciparum carbonic anhydrase 0.0141 0.0413 0.0688
Echinococcus multilocularis geminin 0.0862 0.3397 0.3384
Plasmodium vivax hypothetical protein 0.0064 0.0098 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.04 0.0602
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0278 0.0259
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0361 0.0539
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Echinococcus multilocularis lamin dm0 0.0135 0.0391 0.0372
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Brugia malayi Polyprenyl synthetase family protein 0.1401 0.5624 0.9044
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0274 0.0963 0.1056
Onchocerca volvulus Matrilysin homolog 0.02 0.0658 0.3598
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2199
Echinococcus granulosus serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Schistosoma mansoni survival motor neuron protein 0.0195 0.0636 0.0631
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0064 0.0098 0.0125
Loa Loa (eye worm) hypothetical protein 0.0732 0.286 0.3135
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0064 0.0098 0.0093
Trypanosoma brucei carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Echinococcus granulosus geminin 0.0862 0.3397 0.3384
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0195 0.0636 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Entamoeba histolytica Thymidylate kinase, putative 0.029 0.1031 0.1618
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Brugia malayi hypothetical protein 0.0077 0.0152 0.02
Loa Loa (eye worm) carbonic anhydrase 3 0.0236 0.0806 0.0884
Loa Loa (eye worm) phosphatidylinositol 3 0.2247 0.9122 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Mycobacterium leprae PROBABLE HYDROLASE 0.007 0.012 0.0371
Brugia malayi exodeoxyribonuclease III family protein 0.0095 0.0222 0.0315
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Echinococcus multilocularis musashi 0.0135 0.0391 0.0372
Echinococcus granulosus lamin dm0 0.0135 0.0391 0.0372
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0095 0.0222 0.0348
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0057 0.0066 0.0068
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.1841 0.2887
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.029 0.1031 0.6564
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.077
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0236 0.0806 0.1259
Loa Loa (eye worm) hypothetical protein 0.0065 0.0101 0.0111
Echinococcus multilocularis Zinc finger, PHD finger 0.0274 0.0963 0.0945
Brugia malayi carbohydrate phosphorylase 0.0111 0.0291 0.0425
Toxoplasma gondii exonuclease III APE 0.0095 0.0222 0.0348
Loa Loa (eye worm) hypothetical protein 0.007 0.0121 0.0133
Brugia malayi thymidylate kinase 0.029 0.1031 0.1621
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0107 0.0272 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Echinococcus multilocularis Protein lozenge 0.0057 0.0067 0.0048
Brugia malayi hypothetical protein 0.0954 0.3775 0.6057
Mycobacterium ulcerans cytidine deaminase 0.0057 0.0066 0.0064
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1544 0.6215 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107 0.0272 0.0436
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0252 0.04
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Onchocerca volvulus Matrilysin homolog 0.0057 0.0068 0.0017
Schistosoma mansoni hypothetical protein 0.0108 0.0278 0.0274
Giardia lamblia Farnesyl diphosphate synthase 0.1401 0.5624 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0381 0.0362
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0125
Giardia lamblia Glycogen phosphorylase 0.0111 0.0291 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Echinococcus granulosus tar DNA binding protein 0.0128 0.0361 0.0342
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.324
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1509
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Echinococcus granulosus carbonic anhydrase II 0.0236 0.0806 0.0788
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1218 0.4869 0.7811
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0028 0.0008
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0272 0.0298
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Loa Loa (eye worm) hypothetical protein 0.0135 0.0391 0.0429
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Loa Loa (eye worm) hypothetical protein 0.0071 0.0124 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.033 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Leishmania major farnesyl pyrophosphate synthase 0.1401 0.5624 1
Brugia malayi Pre-SET motif family protein 0.0208 0.0693 0.1075
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0274 0.0963 0.1671
Onchocerca volvulus 0.0195 0.0636 0.346
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1401 0.5624 0.9044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0141 0.0413 0.0452
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0095 0.0222 0.0282
Brugia malayi cytidine deaminase, identical 0.0057 0.0066 0.0061
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0097 0.0234 0.0369
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.013 0.037 0.0365
Onchocerca volvulus 0.0135 0.0391 0.1976
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0098 0.0125
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0245 0.0269
Leishmania major phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Plasmodium vivax thymidylate kinase, putative 0.029 0.1031 0.1792
Loa Loa (eye worm) hypothetical protein 0.0133 0.0381 0.0418
Onchocerca volvulus 0.0163 0.0504 0.2663
Giardia lamblia GTOR 0.0107 0.0272 0.0371
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0028 0.003
Toxoplasma gondii FATC domain-containing protein 0.007 0.0121 0.0167
Echinococcus multilocularis survival motor neuron protein 1 0.0954 0.3775 0.3763
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0064 0.0098 0.0052
Echinococcus granulosus intermediate filament protein 0.0135 0.0391 0.0372
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0363 0.1331 0.1314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Brugia malayi Hemopexin family protein 0.0081 0.0167 0.0226
Echinococcus granulosus lamin 0.0135 0.0391 0.0372
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0811 0.3187 0.5106
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.1574 0.1726
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0412 0.1536 0.1519
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0131 0.0144
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Echinococcus multilocularis thyroid hormone receptor alpha 0.0169 0.0531 0.0512
Brugia malayi thymidylate synthase 0.0163 0.0504 0.077
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0064 0.0098 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0064 0.0098 0.011
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1401 0.5624 0.9044
Echinococcus granulosus cytidine deaminase 0.0057 0.0066 0.0046
Schistosoma mansoni hypothetical protein 0.0195 0.0636 0.0631
Giardia lamblia Thymidine kinase 0.1019 0.4044 0.7158
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Trypanosoma cruzi cytidine deaminase-like protein 0.0057 0.0066 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0361 0.0342
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Echinococcus multilocularis thymidylate synthase 0.0163 0.0504 0.0486
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0095 0.0222 0.0203
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0391 0.0429
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Loa Loa (eye worm) hypothetical protein 0.0071 0.0125 0.0137
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0131 0.0167
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.644 0.6432
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0107 0.0272 0.0436
Leishmania major phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Echinococcus multilocularis carbonic anhydrase II 0.0236 0.0806 0.0788
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0363 0.1331 0.1314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.3514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0095 0.0222 0.0315
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0777 0.134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1544 0.6215 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0281 0.0995 0.0977
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0114 0.014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Entamoeba histolytica hypothetical protein 0.1331 0.5337 0.8581
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.1841 0.1837
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0495 0.1879 0.3308
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1401 0.5624 0.5622
Loa Loa (eye worm) thymidylate kinase 0.029 0.1031 0.113
Loa Loa (eye worm) matrixin family protein 0.0211 0.0706 0.0774
Loa Loa (eye worm) polyprenyl synthetase 0.0412 0.1536 0.1684
Brugia malayi hypothetical protein 0.0108 0.0278 0.0405
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.029 0.1031 0.1792
Trypanosoma brucei cytidine deaminase 0.0057 0.0066 0.0068
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Leishmania major hypothetical protein, unknown function 0.0064 0.0098 0.0125
Entamoeba histolytica thymidine kinase, putative 0.1019 0.4044 0.649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1006 0.3991 0.7063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Schistosoma mansoni glycogen phosphorylase 0.0048 0.003 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Schistosoma mansoni trans-prenyltransferase 0.0412 0.1536 0.1532
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Schistosoma mansoni bromodomain containing protein 0.0063 0.0093 0.0089
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0274 0.0963 0.0945
Echinococcus granulosus thymidylate kinase 0.029 0.1031 0.1013
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0495 0.1879 0.3305
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0148 0.0195
Brugia malayi MH2 domain containing protein 0.0121 0.033 0.0488
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.007 0.012 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0245 0.0291
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.1841 0.2887
Leishmania major hypothetical protein, conserved 0.0114 0.0302 0.049
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0163 0.0504 0.0852
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0412 0.1536 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0412 0.1536 1
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0098 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0064 0.0098 0.0078
Onchocerca volvulus 0.0237 0.0812 0.453
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0348
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Loa Loa (eye worm) hypothetical protein 0.007 0.012 0.0132
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Leishmania major phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Toxoplasma gondii target of rapamycin (TOR), putative 0.0095 0.0224 0.0351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0097 0.0234 0.0369
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.003 0.0004
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.029 0.1031 0.5126
Echinococcus granulosus thymidylate synthase 0.0163 0.0504 0.0486
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0823 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0107 0.0272 0.0436
Onchocerca volvulus 0.0064 0.0098 0.0196
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1223 0.4889 0.4879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Treponema pallidum octaprenyl-diphosphate synthase 0.0573 0.2202 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Plasmodium falciparum thymidylate kinase 0.029 0.1031 0.1792
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Giardia lamblia Deoxynucleoside kinase 0.0397 0.1474 0.2534
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0274 0.0963 0.1512
Onchocerca volvulus 0.0064 0.0098 0.0196
Schistosoma mansoni hypothetical protein 0.0263 0.092 0.0915
Brugia malayi Polyprenyl synthetase family protein 0.0412 0.1536 0.2437
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.1841 0.2887
Mycobacterium ulcerans hydrolase 0.007 0.012 0.0161
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0095 0.0222 0.0311
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0148 0.0162
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Onchocerca volvulus 0.0455 0.1713 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Schistosoma mansoni hypothetical protein 0.024 0.0822 0.0818
Leishmania major thymidylate kinase-like protein 0.029 0.1031 0.1792
Loa Loa (eye worm) matrix metalloproteinase 0.0057 0.0068 0.0075
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0391 0.0587
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0163 0.0504 0.0852
Onchocerca volvulus 0.0135 0.0391 0.1976
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0147
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0599 0.2309 0.3685
Brugia malayi Inositol-1 0.0074 0.0139 0.0179
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Leishmania major cytidine deaminase-like protein 0.0057 0.0066 0.0068
Echinococcus multilocularis serine protein kinase ATM 0.007 0.0121 0.0101
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Loa Loa (eye worm) inositol-1 0.0074 0.0139 0.0152
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0963 0.1459
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0095 0.0222 0.0348
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0071 0.0125 0.0174
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0915 0.3617 0.5801
Echinococcus granulosus solute carrier family 28 0.0363 0.1331 0.1314
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1401 0.5624 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Leishmania major solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0057 0.0066 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0277 0.0976 0.1637
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.0291 0.0319
Loa Loa (eye worm) thymidylate synthase 0.0163 0.0504 0.0553
Brugia malayi TAR-binding protein 0.0128 0.0361 0.0539
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0107 0.0272 0.0395
Schistosoma mansoni hypothetical protein 0.0133 0.0381 0.0376
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Leishmania major carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0163 0.0504 0.2985
Loa Loa (eye worm) phosphatidylinositol kinase 0.0064 0.0098 0.0107
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.007 0.012 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.1841 0.293
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0077 0.0152 0.02
Loa Loa (eye worm) hypothetical protein 0.013 0.037 0.0405
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0064 0.0098 0.0093
Leishmania major phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0125
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0245 0.0351
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0139 0.0194
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Brugia malayi intermediate filament protein 0.0135 0.0391 0.0587
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0026 0.0006
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0139 0.0119
Schistosoma mansoni hypothetical protein 0.0141 0.0413 0.0408
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0098 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Treponema pallidum thymidylate kinase (tmk) 0.029 0.1031 0.4083
Brugia malayi hypothetical protein 0.0455 0.1713 0.2725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0211 0.0236
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2459 1 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.2414
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0064 0.0098 0.0113
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trypanosoma brucei RNA helicase, putative 0.024 0.0822 0.142
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0107 0.0272 0.0267
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Trypanosoma brucei thymidine kinase 0.1019 0.4044 0.7177
Loa Loa (eye worm) matrixin family protein 0.0127 0.0357 0.0391
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0077 0.0148 0.0144
Mycobacterium ulcerans thymidylate synthase 0.0163 0.0504 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Giardia lamblia CDC8 0.029 0.1031 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1544 0.6215 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0113
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1544 0.6215 1
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0495 0.1879 0.3308
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0252 0.04
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0274 0.0963 0.0959
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0139 0.0119
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.0291 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0412 0.1536 0.8029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1331 0.5337 0.8581
Mycobacterium tuberculosis Hypothetical protein 0.0077 0.0152 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0436
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0412 0.1536 0.1519
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Schistosoma mansoni thymidine kinase 0.1223 0.4889 0.4887
Giardia lamblia Phosphatidylinositol 4-kinase 0.0064 0.0098 0.0058
Leishmania major hypothetical protein, conserved 0.0064 0.0098 0.0125
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0361 0.0396
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0095 0.0222 0.0344
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0412 0.1536 0.2435
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0278 0.0259
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0412 0.1536 0.2437
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0064 0.0098 0.0093
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1479 0.5948 0.9569
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0963 0.0959
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0812 0.1214
Schistosoma mansoni fkbp-rapamycin associated protein 0.007 0.0121 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Leishmania major hypothetical protein, conserved 0.0102 0.0252 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0152 0.014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0272 0.0395
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Leishmania major phosphatidylinositol kinase, putative 0.0064 0.0098 0.0125
Loa Loa (eye worm) hypothetical protein 0.0102 0.0252 0.0276
Onchocerca volvulus Matrix metalloproteinase homolog 0.0127 0.0357 0.1769
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0028 0.0023

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0.608 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
Activity (binding) = 0.608 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
IC90 (binding) = 9.02 nM Inhibition of HIV1 reverse transcriptase ChEMBL. 26708112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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