Detailed information for compound 165612

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.83 | Formula: C20H20ClNO4
  • H donors: 2 H acceptors: 3 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)N[C@@H]1c2cc(ccc2OC([C@H]1O)(C)C)C(=O)C
  • InChi: 1S/C20H20ClNO4/c1-11(23)12-7-8-16-15(10-12)17(18(24)20(2,3)26-16)22-19(25)13-5-4-6-14(21)9-13/h4-10,17-18,24H,1-3H3,(H,22,25)/t17-,18+/m1/s1
  • InChiKey: MKZLNLDWNBISMJ-MSOLQXFVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1d (5-HT1d) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 1d (5-HT1d) receptor   374 aa 348 aa 28.2 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 352 aa 21.3 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 1d (5-HT1d) receptor   374 aa 360 aa 23.1 %
Schistosoma mansoni neuropeptide receptor Serotonin 1d (5-HT1d) receptor   374 aa 309 aa 24.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1d (5-HT1d) receptor   374 aa 418 aa 22.2 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 386 aa 33.9 %
Schistosoma mansoni amine GPCR Serotonin 1d (5-HT1d) receptor   374 aa 404 aa 30.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 1d (5-HT1d) receptor   374 aa 363 aa 21.8 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 378 aa 37.3 %
Echinococcus granulosus neuropeptide receptor Serotonin 1d (5-HT1d) receptor   374 aa 335 aa 21.8 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 1d (5-HT1d) receptor   374 aa 359 aa 32.0 %
Echinococcus multilocularis neuropeptide receptor Serotonin 1d (5-HT1d) receptor   374 aa 358 aa 20.9 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Serotonin 1d (5-HT1d) receptor   374 aa 349 aa 34.7 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 1d (5-HT1d) receptor   374 aa 355 aa 36.6 %
Echinococcus granulosus biogenic amine 5HT receptor Serotonin 1d (5-HT1d) receptor   374 aa 402 aa 33.8 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1d (5-HT1d) receptor   374 aa 352 aa 34.7 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 362 aa 33.4 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 332 aa 21.7 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Serotonin 1d (5-HT1d) receptor   374 aa 326 aa 36.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 1d (5-HT1d) receptor   374 aa 348 aa 21.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 1d (5-HT1d) receptor   374 aa 353 aa 22.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1d (5-HT1d) receptor   374 aa 359 aa 33.7 %
Loa Loa (eye worm) hypothetical protein Serotonin 1d (5-HT1d) receptor   374 aa 363 aa 27.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1d (5-HT1d) receptor   374 aa 407 aa 24.3 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1d (5-HT1d) receptor   374 aa 399 aa 25.8 %
Echinococcus granulosus g protein coupled receptor Serotonin 1d (5-HT1d) receptor   374 aa 417 aa 21.6 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 417 aa 21.6 %
Schistosoma mansoni adenoreceptor Serotonin 1d (5-HT1d) receptor   374 aa 348 aa 27.3 %
Schistosoma japonicum Rhodopsin, putative Serotonin 1d (5-HT1d) receptor   374 aa 372 aa 19.6 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 315 aa 21.0 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1d (5-HT1d) receptor   374 aa 330 aa 24.5 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1d (5-HT1d) receptor   374 aa 322 aa 26.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1d (5-HT1d) receptor   374 aa 417 aa 29.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1d (5-HT1d) receptor   374 aa 325 aa 26.2 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 378 aa 24.3 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 400 aa 32.8 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 350 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0005 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0019 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0359 0.1385 0.2632
Echinococcus multilocularis neuropeptide s receptor 0.0116 0.0393 0.039
Loa Loa (eye worm) G-protein coupled receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0228 0.0852 0.1616
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.049 0.192 0.3652
Schistosoma mansoni patched 1 0.0038 0.0074 0.0249
Trypanosoma brucei hexokinase 0.0718 0.2853 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.018 0.0359
Echinococcus multilocularis serotonin receptor 0.0116 0.0393 0.039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0026 0.0043
Brugia malayi Histone deacetylase 1 0.0064 0.018 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Echinococcus granulosus neuropeptide FF receptor 2 0.0116 0.0393 0.0742
Brugia malayi hexokinase 0.0718 0.2853 0.5429
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0084 0.0264 0.0831
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi Serotonin receptor 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0116 0.0393 0.1298
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0507 0.096
Giardia lamblia Kinase, PLK 0.0097 0.0315 0.0281
Echinococcus granulosus neuropeptide receptor 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0338 0.1299 0.4504
Echinococcus multilocularis geminin 0.0175 0.0633 0.063
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0116 0.0393 0.1367
Schistosoma mansoni biogenic amine receptor 0.0116 0.0393 0.1367
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0264 0.0529
Brugia malayi hypothetical protein 0.0373 0.1442 0.2741
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0026 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0094 0.0189
Onchocerca volvulus 0.0488 0.1913 0.6676
Leishmania major histone deacetylase, putative 0.0064 0.018 0.0629
Onchocerca volvulus 0.0116 0.0393 0.1298
Plasmodium vivax histone deacetylase 1, putative 0.0064 0.018 0.0618
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 0.018 0.0629
Echinococcus granulosus somatostatin receptor 0.0116 0.0393 0.0742
Leishmania major hypothetical protein, conserved 0.0021 0.0004 0.0012
Leishmania major hexokinase, putative 0.0718 0.2853 1
Echinococcus granulosus GPCR family 2 0.0148 0.0525 0.0993
Loa Loa (eye worm) hypothetical protein 0.0105 0.0348 0.0656
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0094 0.0189
Trichomonas vaginalis esterase, putative 0.0084 0.0264 0.0529
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0009 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0116 0.0393 0.1367
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0235 0.0232
Schistosoma mansoni neuropeptide receptor 0.0116 0.0393 0.1367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0064 0.018 0.0621
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Schistosoma mansoni neuropeptide receptor 0.0116 0.0393 0.1367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0264 0.0915
Brugia malayi larval opioid receptor 0.0116 0.0393 0.0742
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0315 0.1105
Loa Loa (eye worm) hypothetical protein 0.0051 0.0126 0.0233
Onchocerca volvulus 0.0116 0.0393 0.1298
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi MH2 domain containing protein 0.0133 0.0464 0.0878
Echinococcus granulosus neuropeptides capa receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0026 0.0023
Schistosoma mansoni lamin 0.0105 0.0348 0.1208
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0026 0.0043
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0331
Leishmania major C-8 sterol isomerase-like protein 0.0359 0.1385 0.4854
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0094 0.0319
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0266 0.1007 0.1912
Brugia malayi putative neuropeptide receptor NPR1 0.0116 0.0393 0.0742
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0064 0.018 0.0621
Entamoeba histolytica histone deacetylase, putative 0.0064 0.018 0.0359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0469 0.1833 0.3486
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0281 0.0529
Schistosoma mansoni hypothetical protein 0.032 0.1228 0.4296
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis orexin receptor type 2 0.0116 0.0393 0.039
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0264 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0315 0.1094
Schistosoma mansoni hypothetical protein 0.0037 0.0069 0.0229
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus granulosus tm gpcr rhodopsin 0.0116 0.0393 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0026 0.0043
Onchocerca volvulus 0.0116 0.0393 0.1298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0026 0.0043
Echinococcus granulosus biogenic amine 5HT receptor 0.0116 0.0393 0.0742
Onchocerca volvulus Huntingtin homolog 0.0373 0.1442 0.5009
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0359 0.1385 0.2632
Schistosoma mansoni hypothetical protein 0.0037 0.0069 0.0229
Brugia malayi AF-10 protein 0.0021 0.0005 0.0002
Schistosoma mansoni histone deacetylase 0.0064 0.018 0.0618
Echinococcus granulosus 7tm_1 domain containing protein 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0105 0.0348 0.1137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0042
Mycobacterium ulcerans beta-lactamase 0.0084 0.0264 0.0831
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0014 0.002
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0608 0.24 1
Echinococcus multilocularis peregrin 0.0064 0.018 0.0177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0116 0.0393 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.032 0.1228 0.2332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Echinococcus granulosus snurportin 1 0.0261 0.0983 0.1866
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0315 0.0631
Echinococcus multilocularis PHD finger protein rhinoceros 0.0064 0.018 0.0177
Loa Loa (eye worm) beta-lactamase 0.0084 0.0264 0.0497
Giardia lamblia Fructose-bisphosphate aldolase 0.1244 0.4998 1
Onchocerca volvulus 0.0116 0.0393 0.1298
Toxoplasma gondii hexokinase 0.0718 0.2853 1
Echinococcus granulosus geminin 0.0175 0.0633 0.1199
Brugia malayi hypothetical protein 0.0069 0.0203 0.038
Echinococcus granulosus g protein coupled receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.062 0.2453 0.245
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0281 0.0278
Echinococcus granulosus neuropeptide receptor A26 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0451 0.176 0.6132
Brugia malayi Hexokinase family protein 0.0222 0.0827 0.1569
Brugia malayi Melatonin receptor type 1A 0.0116 0.0393 0.0742
Schistosoma mansoni survival motor neuron protein 0.0266 0.1007 0.3522
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0116 0.0393 0.1367
Brugia malayi histone deacetylase 3 (HD3) 0.0064 0.018 0.0335
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0464 0.0878
Loa Loa (eye worm) hexokinase 0.0451 0.176 0.3346
Schistosoma mansoni neuropeptide F-like receptor 0.0116 0.0393 0.1367
Plasmodium falciparum histone deacetylase 1 0.0064 0.018 0.0618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0183 0.0668 0.1266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0393 0.039
Echinococcus multilocularis fmrfamide receptor 0.0116 0.0393 0.039
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Brugia malayi RNA, U transporter 1 0.0069 0.0203 0.0379
Echinococcus granulosus PHD finger protein rhinoceros 0.0064 0.018 0.0337
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Loa Loa (eye worm) hypothetical protein 0.0469 0.1833 0.3486
Plasmodium vivax SET domain protein, putative 0.0062 0.017 0.0586
Toxoplasma gondii histone deacetylase HDAC3 0.0064 0.018 0.0618
Trypanosoma cruzi hexokinase, putative 0.0718 0.2853 1
Brugia malayi sulfakinin receptor protein 0.0116 0.0393 0.0742
Schistosoma mansoni hypothetical protein 0.0037 0.0069 0.0229
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi histone deacetylase 1 (HD1) 0.0064 0.018 0.0335
Brugia malayi CHE-14 protein 0.0038 0.0074 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Toxoplasma gondii histone deacetylase HDAC2 0.0064 0.018 0.0618
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0469 0.1833 0.3486
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0116 0.0393 0.1367
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0209 0.0775 0.0772
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0161 0.0301
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0126 0.0233
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0025 0.0077
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0084 0.0264 0.0497
Brugia malayi beta-lactamase family protein 0.0084 0.0264 0.0497
Schistosoma mansoni jumonji domain containing protein 0.0166 0.0599 0.209
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0084 0.0264 0.0831
Trichomonas vaginalis set domain proteins, putative 0.0488 0.1913 0.3828
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0115 0.023
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0315 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Echinococcus granulosus peptide allatostatin:somatostatin 0.0116 0.0393 0.0742
Echinococcus granulosus fmrfamide receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis hexokinase type 2 0.0718 0.2853 0.285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0026 0.0043
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0116 0.0393 0.0742
Schistosoma mansoni amine GPCR 0.0116 0.0393 0.1367
Loa Loa (eye worm) hypothetical protein 0.0064 0.018 0.0337
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.017 0.0586
Leishmania major hypothetical protein, conserved 0.0026 0.0025 0.0089
Schistosoma mansoni amine GPCR 0.0116 0.0393 0.1367
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0005 0.0004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0359 0.1385 0.4854
Loa Loa (eye worm) hypothetical protein 0.032 0.1228 0.2332
Schistosoma mansoni opsin-like receptor 0.0116 0.0393 0.1367
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0464 0.0878
Echinococcus granulosus G protein coupled receptor 139 0.0116 0.0393 0.0742
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0019 0.0054
Schistosoma mansoni intermediate filament proteins 0.0105 0.0348 0.1208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0507 0.1768
Entamoeba histolytica hexokinase 2 0.0718 0.2853 0.5708
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0009 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0116 0.0393 0.0742
Mycobacterium tuberculosis Probable lipase LipE 0.0084 0.0264 0.0831
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0025 0.0077
Loa Loa (eye worm) hypothetical protein 0.0103 0.034 0.0641
Loa Loa (eye worm) hypothetical protein 0.011 0.0367 0.0693
Brugia malayi Hexokinase family protein 0.0718 0.2853 0.5429
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0373 0.1442 0.2741
Leishmania major hexokinase, putative 0.0718 0.2853 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0026 0.0043
Schistosoma mansoni hypothetical protein 0.0261 0.0983 0.3438
Echinococcus granulosus jumonji domain containing protein 0.0089 0.0283 0.0532
Loa Loa (eye worm) intermediate filament protein 0.0105 0.0348 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0026 0.0043
Mycobacterium ulcerans hypothetical protein 0.0084 0.0264 0.0831
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0469 0.1833 0.3486
Onchocerca volvulus 0.0116 0.0393 0.1298
Mycobacterium tuberculosis Possible penicillin-binding protein 0.054 0.2123 0.8811
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0507 0.1768
Schistosoma mansoni importin beta-1 0.0024 0.0019 0.0054
Chlamydia trachomatis glutamine binding protein 0.0037 0.0071 0.5
Onchocerca volvulus 0.0084 0.0264 0.0842
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0025 0.0077
Mycobacterium tuberculosis Probable hydrolase 0.0084 0.0264 0.0831
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0116 0.0393 0.039
Entamoeba histolytica hypothetical protein 0.0069 0.0203 0.0406
Loa Loa (eye worm) G-protein coupled receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0116 0.0393 0.039
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0116 0.0393 0.0742
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.018 0.0337
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1244 0.4998 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0126 0.0122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0014 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0026 0.0043
Brugia malayi RE15519p 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0315 0.0594
Echinococcus multilocularis neuropeptide FF receptor 2 0.0116 0.0393 0.039
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0264 0.0915
Echinococcus multilocularis hexokinase 0.0718 0.2853 0.285
Echinococcus granulosus allatostatin A receptor 0.0116 0.0393 0.0742
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0148 0.0525 0.0993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Schistosoma mansoni coup transcription factor 0.0026 0.0026 0.008
Plasmodium vivax hexokinase, putative 0.0718 0.2853 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0507 0.0504
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Brugia malayi steroid hormone receptor 0.0026 0.0026 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0264 0.0926
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0116 0.0393 0.0742
Entamoeba histolytica hexokinase 1 0.0718 0.2853 0.5708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0266 0.1007 0.3522
Echinococcus granulosus beta LACTamase domain containing family member 0.0084 0.0264 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0026 0.0043
Mycobacterium tuberculosis Conserved protein 0.0084 0.0264 0.0831
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0116 0.0393 0.0742
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.017 0.0586
Loa Loa (eye worm) hexokinase 0.0718 0.2853 0.5429
Brugia malayi GnHR receptor homolog 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni histone deacetylase 0.0064 0.018 0.0618
Schistosoma mansoni histamine h1 receptor 0.0116 0.0393 0.1367
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0281 0.0562
Mycobacterium tuberculosis Probable lipase LipD 0.0084 0.0264 0.0831
Brugia malayi Hexokinase family protein 0.0451 0.176 0.3346
Echinococcus granulosus biogenic amine 5HT receptor 0.0116 0.0393 0.0742
Brugia malayi G-protein coupled receptor 0.0116 0.0393 0.0742
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0026 0.0043
Entamoeba histolytica hypothetical protein 0.0069 0.0203 0.0406
Brugia malayi G-protein coupled receptor 0.0116 0.0393 0.0742
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0026 0.0043
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0261 0.0983 0.1866
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0116 0.0393 0.0742
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0393 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.017 0.0586
Echinococcus multilocularis jumonji domain containing protein 0.0089 0.0283 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0235 0.0442
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Brugia malayi hypothetical protein 0.0338 0.1299 0.2469
Schistosoma mansoni hypothetical protein 0.0148 0.0525 0.1829
Schistosoma mansoni neuropeptide receptor 0.0116 0.0393 0.1367
Treponema pallidum fructose-bisphosphate aldolase 0.1244 0.4998 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0525 0.0993
Onchocerca volvulus 0.0116 0.0393 0.1298
Echinococcus granulosus alpha 1A adrenergic receptor 0.0116 0.0393 0.0742
Leishmania major hypothetical protein, conserved 0.0084 0.0264 0.0926
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0026 0.008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0393 0.1367
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0005 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0026 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0094 0.0173
Echinococcus granulosus dro:myosuppressin receptor 0.0116 0.0393 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.017 0.0167
Onchocerca volvulus 0.0266 0.1007 0.3469
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0608 0.24 1
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0094 0.0091
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0009 0.001
Echinococcus multilocularis hexokinase 0.0718 0.2853 0.285
Echinococcus multilocularis fmrfamide receptor 0.0116 0.0393 0.039
Echinococcus granulosus lamin 0.0105 0.0348 0.0656
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0264 0.0915
Echinococcus multilocularis G-protein coupled receptor, putative 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni amine GPCR 0.0116 0.0393 0.1367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0026 0.0023
Echinococcus granulosus intermediate filament protein 0.0105 0.0348 0.0656
Onchocerca volvulus 0.0116 0.0393 0.1298
Echinococcus granulosus lamin dm0 0.0105 0.0348 0.0656
Echinococcus multilocularis allatostatin A receptor 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0116 0.0393 0.1367
Brugia malayi PHD-finger family protein 0.0064 0.018 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Echinococcus granulosus survival motor neuron protein 1 0.1306 0.5252 1
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0026 0.0023
Schistosoma mansoni hypothetical protein 0.0175 0.0633 0.2209
Schistosoma mansoni lamin 0.0105 0.0348 0.1208
Echinococcus multilocularis histone deacetylase 1 0.0064 0.018 0.0176
Brugia malayi G protein-coupled receptor F59B2.13 0.0116 0.0393 0.0742
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0116 0.0393 0.0742
Plasmodium vivax hypothetical protein, conserved 0.0064 0.018 0.0621
Echinococcus multilocularis neuropeptide Y receptor 0.0116 0.0393 0.039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi Bromodomain containing protein 0.0064 0.018 0.0337
Entamoeba histolytica hypothetical protein 0.0069 0.0203 0.0406
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0026 0.008
Trypanosoma brucei hexokinase 0.0718 0.2853 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni myosin xvIII 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0148 0.0525 0.1829
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0116 0.0393 0.039
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Onchocerca volvulus Huntingtin homolog 0.0373 0.1442 0.5009
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0026 0.008
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0315 0.1105
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Mycobacterium leprae conserved hypothetical protein 0.0084 0.0264 0.0809
Brugia malayi neuropeptide F receptor 0.0116 0.0393 0.0742
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni hexokinase 0.0718 0.2853 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0026 0.0043
Trypanosoma brucei C-8 sterol isomerase, putative 0.0359 0.1385 0.4848
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0026 0.0043
Brugia malayi jmjC domain containing protein 0.0209 0.0775 0.1469
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0175 0.0633 0.2209
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.1671 0.3177
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0009 0.0018
Plasmodium falciparum hexokinase 0.0718 0.2853 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0373 0.1442 0.2741
Trypanosoma brucei histone deacetylase 1 0.0064 0.018 0.0618
Onchocerca volvulus 0.0116 0.0393 0.1298
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0116 0.0393 0.1367
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni hypothetical protein 0.0116 0.0393 0.1367
Echinococcus granulosus 7TM GPCR rhodopsin 0.0116 0.0393 0.0742
Brugia malayi Dopamine receptor protein 1 0.0116 0.0393 0.0742
Echinococcus granulosus peregrin 0.0064 0.018 0.0337
Brugia malayi Pre-SET motif family protein 0.0062 0.017 0.0318
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.013 0.0126
Onchocerca volvulus 0.0105 0.0348 0.1137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0507 0.1768
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0264 0.0915
Loa Loa (eye worm) hypothetical protein 0.0038 0.0074 0.0135
Plasmodium falciparum phd finger protein, putative 0.0064 0.018 0.0621
Schistosoma mansoni hypothetical protein 0.0148 0.0525 0.1829
Echinococcus multilocularis beta LACTamase domain containing family member 0.0084 0.0264 0.0261
Echinococcus granulosus hexokinase type 2 0.0718 0.2853 0.5429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0264 0.0529
Echinococcus multilocularis Niemann Pick C1 protein 0.0127 0.0436 0.0433
Plasmodium falciparum importin beta, putative 0.0024 0.0019 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0507 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0026 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Echinococcus granulosus neuropeptide s receptor 0.0116 0.0393 0.0742
Echinococcus granulosus importin subunit beta 1 0.0024 0.0019 0.0029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0116 0.0393 0.039
Brugia malayi AKH receptor 0.0116 0.0393 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0115 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Echinococcus granulosus tachykinin peptides receptor 99D 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi hexokinase type II 0.0228 0.0852 0.1616
Echinococcus multilocularis g-protein coupled receptor 0.0116 0.0393 0.039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0021 0.0005 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0393 0.1367
Schistosoma mansoni adenoreceptor 0.0116 0.0393 0.1367
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0116 0.0393 0.039
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0235 0.0442
Echinococcus multilocularis musashi 0.0105 0.0348 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0026 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Echinococcus granulosus hypothetical protein 0.0116 0.0393 0.0742
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.017 0.0318
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0094 0.0189
Onchocerca volvulus 0.0116 0.0393 0.1298
Echinococcus multilocularis survival motor neuron protein 1 0.1306 0.5252 0.5251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Onchocerca volvulus Alhambra homolog 0.0064 0.018 0.0545
Brugia malayi hypothetical protein 0.1306 0.5252 1
Echinococcus granulosus g protein coupled receptor 0.0116 0.0393 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0074 0.0149
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0116 0.0393 0.0742
Schistosoma mansoni biogenic amine receptor 0.0116 0.0393 0.1367
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0235 0.0814
Trypanosoma cruzi hexokinase, putative 0.0718 0.2853 1
Loa Loa (eye worm) histone deacetylase 1 0.0064 0.018 0.0335
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0507 0.096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0026 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0026 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0074 0.0135
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0026 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0026 0.0043
Echinococcus granulosus hexokinase 0.0718 0.2853 0.5429
Schistosoma mansoni inositol monophosphatase 0.0043 0.0094 0.0319
Echinococcus granulosus sex peptide receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Schistosoma mansoni hypothetical protein 0.0148 0.0525 0.1829
Echinococcus granulosus g protein coupled receptor 0.0116 0.0393 0.0742
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0116 0.0393 0.1298
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.018 0.0621
Brugia malayi beta-lactamase 0.0084 0.0264 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0116 0.0393 0.039
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi Latrophilin receptor protein 2 0.0148 0.0525 0.0993
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0116 0.0393 0.1298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0084 0.0264 0.0831
Onchocerca volvulus 0.0718 0.2853 1
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0393 0.1367
Echinococcus multilocularis G protein coupled receptor 139 0.0116 0.0393 0.039
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.018 0.0621
Onchocerca volvulus 0.0718 0.2853 1
Mycobacterium tuberculosis Conserved protein 0.0084 0.0264 0.0831
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.013 0.0241
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi follicle stimulating hormone receptor 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0116 0.0393 0.1298
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0148 0.0525 0.0993
Brugia malayi Importin beta-1 subunit 0.0024 0.0019 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0026 0.0043
Echinococcus multilocularis expressed conserved protein 0.0083 0.0259 0.0256
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0235 0.0814
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.018 0.0359
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Schistosoma mansoni hypothetical protein 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0116 0.0393 0.1367
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0074 0.0135
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0315 0.0594
Loa Loa (eye worm) histone deacetylase 3 0.0064 0.018 0.0335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0331
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0116 0.0393 0.0742
Schistosoma mansoni amine GPCR 0.0116 0.0393 0.1367
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi ecdysteroid receptor 0.0026 0.0026 0.0043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0116 0.0393 0.1367
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0026 0.0043
Onchocerca volvulus Hexokinase homolog 0.0451 0.176 0.6132
Schistosoma mansoni opsin-like receptor 0.0116 0.0393 0.1367
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0026 0.0023
Onchocerca volvulus 0.0116 0.0393 0.1298
Loa Loa (eye worm) latrophilin receptor protein 2 0.0148 0.0525 0.0993
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0025 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0116 0.0393 0.0742
Echinococcus granulosus Niemann Pick C1 protein 0.0127 0.0436 0.0825
Mycobacterium ulcerans esterase/lipase LipP 0.0084 0.0264 0.0831
Schistosoma mansoni alpha-1 adrenergic receptor 0.0116 0.0393 0.1367
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0056 0.0149 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0026 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.017 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Echinococcus multilocularis hexokinase 0.0718 0.2853 0.285
Schistosoma mansoni biogenic amine (5HT) receptor 0.0116 0.0393 0.1367
Brugia malayi hypothetical protein 0.0026 0.0025 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0026 0.0043
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0025 0.0089
Loa Loa (eye worm) hypothetical protein 0.0338 0.1299 0.2469
Brugia malayi intermediate filament protein 0.0105 0.0348 0.0656
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1244 0.4998 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0116 0.0393 0.1298
Schistosoma mansoni neuropeptide F-like receptor 0.0116 0.0393 0.1367
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0037 0.0071 0.5
Brugia malayi nuclear hormone receptor 0.0026 0.0026 0.0043
Brugia malayi Pre-SET motif family protein 0.0429 0.1671 0.3177
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0203 0.02
Echinococcus granulosus serotonin receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis somatostatin receptor 0.0116 0.0393 0.039
Echinococcus multilocularis neuropeptides capa receptor 0.0116 0.0393 0.039
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0608 0.24 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0116 0.0393 0.1367
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0084 0.0264 0.0831
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0009 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0026 0.008
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0393 0.039
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0009 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0105 0.0348 0.0656
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0209 0.0775 0.1469
Echinococcus multilocularis dro:myosuppressin receptor 0.0116 0.0393 0.039
Brugia malayi cytoplasmic intermediate filament protein 0.0056 0.0149 0.0277
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis sex peptide receptor 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Schistosoma mansoni niemann-pick C1 (NPC1) 0.009 0.0287 0.0994
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0203 0.07
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0026 0.0023
Onchocerca volvulus 0.0084 0.0264 0.0842
Schistosoma mansoni hypothetical protein 0.0069 0.0203 0.07
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0116 0.0393 0.039
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0076 0.0023
Echinococcus multilocularis neuropeptide receptor 0.0116 0.0393 0.039
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0094 0.0102
Loa Loa (eye worm) inositol-1 0.0043 0.0094 0.0173
Echinococcus multilocularis lamin 0.0105 0.0348 0.0344
Onchocerca volvulus 0.0116 0.0393 0.1298
Schistosoma mansoni inositol monophosphatase 0.0043 0.0094 0.0319
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0116 0.0393 0.039
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0331
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0116 0.0393 0.1367
Loa Loa (eye worm) hypothetical protein 0.0064 0.018 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0264 0.0926
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Echinococcus multilocularis protein dispatched 1 0.0043 0.0096 0.0093
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0116 0.0393 0.0742
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0009 0.0005
Schistosoma mansoni biogenic amine receptor 0.0116 0.0393 0.1367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0026 0.0023
Onchocerca volvulus 0.0062 0.017 0.051
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0029
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Loa Loa (eye worm) hexokinase type II 0.0718 0.2853 0.5429
Echinococcus multilocularis neuropeptide Y receptor 0.0116 0.0393 0.039
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0026 0.0043
Echinococcus multilocularis protein patched 0.0038 0.0074 0.0071
Brugia malayi Inositol-1 0.0043 0.0094 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0025 0.0089
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0393 0.1367
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0074 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.017 0.0586
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0315 0.1022
Loa Loa (eye worm) hypothetical protein 0.1306 0.5252 1
Mycobacterium leprae Probable lipase LipE 0.0084 0.0264 0.0809
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0026 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0148 0.0525 0.0521
Echinococcus multilocularis lamin dm0 0.0105 0.0348 0.0344
Schistosoma mansoni kinase 0.0049 0.012 0.041
Echinococcus multilocularis neuropeptide receptor 0.0116 0.0393 0.039
Loa Loa (eye worm) hexokinase 0.0222 0.0827 0.1569
Echinococcus granulosus hexokinase 0.0718 0.2853 0.5429
Loa Loa (eye worm) hexokinase 0.0718 0.2853 0.5429
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0084 0.0264 0.0497
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0026 0.0023
Giardia lamblia PHD finger protein 15 0.0064 0.018 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0026 0.0043
Brugia malayi neuropeptide F receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) neuropeptide F receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0116 0.0393 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0026 0.0043
Echinococcus granulosus tm gpcr rhodopsin 0.0116 0.0393 0.0742
Entamoeba histolytica hypothetical protein 0.0069 0.0203 0.0406
Toxoplasma gondii ABC1 family protein 0.0084 0.0264 0.0915
Onchocerca volvulus 0.0116 0.0393 0.1298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0026 0.0043
Echinococcus multilocularis GPCR, family 2 0.0148 0.0525 0.0521
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0019 0.0054
Echinococcus granulosus expressed conserved protein 0.0083 0.0259 0.0487
Schistosoma mansoni opsin-like receptor 0.0116 0.0393 0.1367
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0116 0.0393 0.1367
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0094 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0094 0.0189
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0005 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0084 0.0264 0.0831
Echinococcus granulosus neuropeptide Y receptor 0.0116 0.0393 0.0742
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 0.018 0.0629
Echinococcus granulosus hexokinase 0.0718 0.2853 0.5429
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0203 0.038
Echinococcus granulosus histone deacetylase 3 0.0064 0.018 0.0335
Schistosoma mansoni neuropeptide f receptor 76f 0.0116 0.0393 0.1367
Brugia malayi Tachykinin-like peptides receptor 99D 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0228 0.0852 0.1616
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0026 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0507 0.096
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Onchocerca volvulus 0.0084 0.0264 0.0842
Brugia malayi ORL1-like opioid receptor 0.0116 0.0393 0.0742
Mycobacterium tuberculosis Conserved protein 0.0084 0.0264 0.0831
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0009 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0264 0.0529
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.0459 0.0867
Echinococcus granulosus orexin receptor type 2 0.0116 0.0393 0.0742
Echinococcus granulosus g-protein coupled receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0009 0.0005
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Schistosoma mansoni hypothetical protein 0.0116 0.0393 0.1367
Onchocerca volvulus Neuropeptide F receptor homolog 0.0116 0.0393 0.1298
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) melatonin receptor type 1A 0.0116 0.0393 0.0742
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0281 0.0529
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0393 0.0742
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.018 0.0359
Brugia malayi Serotonin receptor 0.0116 0.0393 0.0742
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0315 0.0594
Brugia malayi jmjC domain containing protein 0.0077 0.0235 0.0442
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0116 0.0393 0.039
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.018 0.0359
Echinococcus granulosus neuropeptides capa receptor 0.0116 0.0393 0.0742
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0005 0.0004
Schistosoma mansoni amine GPCR 0.0116 0.0393 0.1367
Loa Loa (eye worm) hypothetical protein 0.0429 0.1669 0.3174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0026 0.0043
Loa Loa (eye worm) neuropeptide F receptor 0.0116 0.0393 0.0742
Echinococcus multilocularis neuropeptides capa receptor 0.0116 0.0393 0.039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0116 0.0393 0.039
Loa Loa (eye worm) hypothetical protein 0.0062 0.017 0.0318
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0315 0.0631
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0148 0.0525 0.0521
Loa Loa (eye worm) hypothetical protein 0.0047 0.0109 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0026 0.0043
Onchocerca volvulus 0.0718 0.2853 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0507 0.0504
Brugia malayi Dopamine receptor 0.0116 0.0393 0.0742
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0116 0.0393 0.0742
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1244 0.4998 1
Echinococcus multilocularis snurportin 1 0.0261 0.0983 0.098
Brugia malayi beta-lactamase family protein 0.0084 0.0264 0.0497
Echinococcus granulosus neuropeptide receptor 0.0116 0.0393 0.0742
Treponema pallidum hexokinase (hxk) 0.0718 0.2853 0.5646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0116 0.0393 0.1367
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trypanosoma brucei polo-like protein kinase 0.0097 0.0315 0.1094
Schistosoma mansoni neuropeptide receptor 0.0116 0.0393 0.1367
Schistosoma mansoni hypothetical protein 0.0037 0.0069 0.0229
Echinococcus granulosus histone deacetylase 1 0.0064 0.018 0.0335
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.013 0.0126
Echinococcus multilocularis neuropeptide receptor A26 0.0116 0.0393 0.039
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0116 0.0393 0.1367
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0025 0.0077
Loa Loa (eye worm) TYRA-2 protein 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0089 0.0281 0.0529
Trypanosoma brucei hexokinase, putative 0.0718 0.2853 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0084 0.0264 0.0497
Brugia malayi nuclear receptor NHR-88 0.0026 0.0026 0.0043
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0074 0.0135
Leishmania major histone deacetylase, putative 0.0064 0.018 0.0629
Echinococcus multilocularis histone deacetylase 3 0.0064 0.018 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0002
Echinococcus granulosus glutamate receptor 2 0.0022 0.0009 0.001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0116 0.0393 0.039
Brugia malayi G protein-coupled receptor 0.0116 0.0393 0.0742
Brugia malayi putative neuropeptide receptor 0.0116 0.0393 0.0742
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0393 0.039
Echinococcus multilocularis serotonin receptor 0.0116 0.0393 0.039
Mycobacterium ulcerans lipase LipD 0.0084 0.0264 0.0831
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0026 0.008
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0116 0.0393 0.0742
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0315 0.1105
Brugia malayi PHD-finger family protein 0.0021 0.0005 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.017 0.0167
Plasmodium vivax importin-beta 2, putative 0.0024 0.0019 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0026 0.0043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0148 0.0525 0.0993
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0264 0.0529
Brugia malayi Intermediate filament tail domain containing protein 0.0105 0.0348 0.0656
Onchocerca volvulus 0.0116 0.0393 0.1298
Echinococcus granulosus tm gpcr rhodopsin 0.062 0.2453 0.4667
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0026 0.0043
Brugia malayi Dopamine receptor protein 2 0.0116 0.0393 0.0742
Brugia malayi hypothetical protein 0.0116 0.0393 0.0742

Activities

Activity type Activity value Assay description Source Reference
Increase (functional) % In vivo percent increase in seizure threshold in mouse MEST model at the dose of 10 mg/kg p.o. recorded 1 hr post dose; Not determined ChEMBL. 10021946
Increase (functional) 0 % In vivo percent increase in seizure threshold in mouse MEST model at the dose of 10 mg/kg p.o. recorded 1 hr post dose; Not determined ChEMBL. 10021946
Increase (functional) 0 % In vivo percent increase in seizure threshold in rat MEST model at the dose of 10 mg/kg p.o. recorded 4 hr post dose; Not determined ChEMBL. 10021946
Ki (binding) < -5.2 Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement. ChEMBL. 10021946
Log Ki (binding) < 5.2 Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement. ChEMBL. 10021946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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