Detailed information for compound 1678283

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1172.3 | Formula: C57H61N3O18S3
  • H donors: 7 H acceptors: 14 LogP: 6.38 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 4
  • SMILES: Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)N(S(=O)(=O)C)S(=O)(=O)C.OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@@H]([C@@H](O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC
  • InChi: 1S/C30H32N2O7S3.C27H29NO11/c1-41(35,36)32(42(2,37)38)23-10-6-22(7-11-23)30-28(26-15-12-24(33)20-27(26)40-30)29(34)21-8-13-25(14-9-21)39-19-18-31-16-4-3-5-17-31;1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h6-15,20,33H,3-5,16-19H2,1-2H3;3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t;10-,13-,15-,17-,22+,27-/m.0/s1
  • InChiKey: LBVXLYKKAVPSBB-NNKUIFFVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0283 0.2 0.2
Brugia malayi Csnk2b protein 0.0036 0.016 0.0284
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0046
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.068 1
Schistosoma mansoni survival motor neuron protein 0.0094 0.0596 0.0684
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.009 0.009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1186 0.87 0.87
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.033 0.0531
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0156 0.0155
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0419 0.3004 0.5372
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0145 0.0974 0.1266
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0283 0.2 0.2
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0591 0.1001
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0156 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.016 0.1082 0.5325
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis expressed conserved protein 0.0158 0.107 0.1069
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0635 0.1133
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0136 0.0907 0.1604
Trypanosoma cruzi target of rapamycin kinase 3 0.0257 0.1802 0.3209
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0312 0.2214 1
Giardia lamblia Kinase, CMGC GSK 0.005 0.0264 0.0537
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0059 0.0103
Onchocerca volvulus 0.0094 0.0596 0.2372
Brugia malayi Protein kinase domain containing protein 0.0312 0.2214 0.3958
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0034
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.068 0.0885
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0106 0.0105
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0596 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0907 0.157
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.1279 0.224
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0127 0.0127
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0599 0.4342 0.5651
Leishmania major cytochrome p450-like protein 0.0019 0.0036 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Toxoplasma gondii target of rapamycin (TOR), putative 0.025 0.1751 1
Onchocerca volvulus 0.0099 0.0635 0.2554
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.013 0.0861 0.1121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.2 0.3575
Plasmodium falciparum casein kinase II beta chain 0.0036 0.016 0.1357
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0537 0.3879 0.3879
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0036 0.0004
Echinococcus multilocularis lamin dm0 0.0026 0.0093 0.0092
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.009 0.0159
Brugia malayi hypothetical protein 0.0035 0.0156 0.0276
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0127 0.0127
Giardia lamblia GTOR 0.0283 0.2 0.6512
Leishmania major phosphatidylinositol 3-kinase, putative 0.0197 0.1355 0.3586
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.1279 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Onchocerca volvulus 0.0099 0.0635 0.2554
Echinococcus multilocularis casein kinase ii subunit alpha 0.0133 0.0884 0.0884
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0283 0.2 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0031 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0193 0.133 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0036 0.0046
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0238 0.0272
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Trypanosoma brucei Casein kinase II 0.0133 0.0884 0.4319
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.068 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0883 0.1527
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0058 0.033 0.1496
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0034 0.0059
Loa Loa (eye worm) hypothetical protein 0.0122 0.0801 0.1042
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.033 0.3378
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0073 0.0083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0283 0.2 0.3537
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0156 0.1861
Brugia malayi hypothetical protein 0.0462 0.3327 0.5948
Plasmodium falciparum casein kinase 2, alpha subunit 0.0133 0.0884 0.9051
Brugia malayi hypothetical protein 0.01 0.0635 0.1134
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0145 0.0974 0.1739
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0799
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.1279 0.5594
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0174 0.1186 0.1543
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.1496
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.004 0.0196 0.033
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0059 0.0076
Loa Loa (eye worm) hypothetical protein 0.0159 0.1074 0.1397
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0537 0.3879 0.3879
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0264 0.0413
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.042 0.3014 1
Brugia malayi Serotonin receptor 0.0453 0.3262 0.5832
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0133 0.0884 0.115
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0282 0.1991 0.3521
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0127 0.0127
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0145 0.0974 0.169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Echinococcus granulosus voltage dependent calcium channel 0.0031 0.0127 0.0127
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0282 0.1991 0.3521
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.009 0.0101
Brugia malayi PAS domain containing protein 0.0047 0.0247 0.0439
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0034 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0767 0.5592 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Giardia lamblia Kinase, CMGC GSK 0.005 0.0264 0.0537
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0145 0.0974 0.169
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.016 0.0397
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0145 0.0974 1
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0537 0.3879 0.5049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Entamoeba histolytica casein kinase, putative 0.0133 0.0884 0.1529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0117
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.068 0.3281
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0197 0.1355 0.6715
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0108 0.0132
Brugia malayi hypoxia-induced factor 1 0.0146 0.0983 0.1755
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0034
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0264 0.0263
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0108 0.0616
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0108 0.0132
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.016 0.0634
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.1432 0.1864
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0328
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.057
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0245 0.1718 0.3057
Leishmania major phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.0849
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.009 0.0101
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0061 0.0069
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0093 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.011 0.0143
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0073 0.0435 0.0759
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0036 0.0361
Brugia malayi hypothetical protein 0.0019 0.0034 0.0059
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.068 0.0781
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0043
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0264 0.0452
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0238 0.0272
Plasmodium falciparum casein kinase II beta chain 0.0036 0.016 0.1357
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi PXA domain containing protein 0.002 0.0045 0.0077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.1279 0.1279
Echinococcus granulosus protein kinase shaggy 0.005 0.0264 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.033 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0283 0.2 0.3537
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.0551 0.0551
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Leishmania major hypothetical protein, unknown function 0.0058 0.033 0.0849
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0329 0.2336 0.2684
Echinococcus granulosus intermediate filament protein 0.0026 0.0093 0.0092
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0036 0.0046
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0245 0.1718 0.1974
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0551 0.0633
Schistosoma mansoni protein kinase 0.0133 0.0884 0.1016
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0052 0.0031
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0427 0.0427
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0036 0.0207
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0061 0.0079
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0264 0.1507
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0034 0.0034
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0336 0.153
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.1097
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.0336 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5748 0.5747
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0283 0.2 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0058 0.033 0.3156
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0168 0.1142 0.1141
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.4774
Toxoplasma gondii hypothetical protein 0.0052 0.0282 0.1611
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0114 0.0113
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0031 0.0127 0.0127
Trypanosoma cruzi casein kinase II, putative 0.0133 0.0884 0.1564
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0312 0.2214 0.2881
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.1604 0.2824
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0245 0.1718 0.3057
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Schistosoma mansoni hypothetical protein 0.0166 0.1132 0.13
Echinococcus granulosus high voltage activated calcium channel beta 0.0084 0.0522 0.0521
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Toxoplasma gondii hypothetical protein 0.0019 0.0036 0.0207
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0196 0.1347 0.4265
Entamoeba histolytica protein kinase rad3, putative 0.0122 0.0801 0.138
Brugia malayi Casein kinase II, alpha chain 0.0133 0.0884 0.1579
Loa Loa (eye worm) hypothetical protein 0.01 0.0635 0.0826
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0264 0.0343
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0326 0.2319 0.4111
Trypanosoma cruzi hypothetical protein, conserved 0.0462 0.3324 0.5936
Giardia lamblia Casein kinase II beta chain 0.0036 0.016 0.018
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0034 0.0034
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0122 0.0801 0.0801
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0034 0.0059
Leishmania major phosphatidylinositol 3-kinase, putative 0.0145 0.0974 0.2568
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.009 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0368 0.06
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0127 0.0127
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0034 0.0044
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0245 0.1718 0.1717
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0058 0.033 0.0531
Brugia malayi hypothetical protein 0.0019 0.0034 0.0059
Brugia malayi intermediate filament protein 0.0026 0.0093 0.0163
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0099 0.0635 0.0825
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0283 0.2 0.3563
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.009 0.009
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0257 0.1802 0.8993
Brugia malayi phosphofructokinase 0.0106 0.068 0.1215
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0974 0.5559
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.016 0.0319
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0264 0.0413
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0062
Schistosoma mansoni neprilysin 0.0024 0.0073 0.0083
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0114 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.0879 0.1519
Brugia malayi Angiotensin-converting enzyme family protein 0.0599 0.4342 0.7764
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Echinococcus granulosus expressed conserved protein 0.0158 0.107 0.1069
Mycobacterium leprae conserved hypothetical protein 0.0058 0.033 0.4554
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Loa Loa (eye worm) calcium channel 0.0031 0.0127 0.0165
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0709 0.5158 0.922
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0145 0.0974 0.1118
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.1279 0.2272
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0093 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0336 0.0336
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.063 0.4574 0.8169
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0132 0.0879 0.1519
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0264 0.0343
Schistosoma mansoni hypothetical protein 0.0051 0.0273 0.0313
Echinococcus multilocularis musashi 0.0026 0.0093 0.0092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0767 0.5592 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0052 0.009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.009 0.0103
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0145 0.0974 0.0973
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1414 0.1839
Echinococcus multilocularis geminin 0.0166 0.1132 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0573 0.8336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Echinococcus multilocularis Zinc finger, PHD finger 0.0145 0.0974 0.0973
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0253 0.029
Echinococcus granulosus serine protein kinase ATM 0.0136 0.0907 0.0906
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0257 0.1802 0.478
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0136 0.0907 0.1042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0115
Schistosoma mansoni intermediate filament proteins 0.0026 0.0093 0.0106
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0573 0.8335
Brugia malayi follicle stimulating hormone receptor 0.023 0.1602 0.2863
Loa Loa (eye worm) phosphatidylinositol kinase 0.0058 0.033 0.0428
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0264 0.2457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Loa Loa (eye worm) Csnk2b protein 0.0036 0.016 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0573 0.3273
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.016 0.0319
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0029 0.0114 0.0147
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Giardia lamblia Phosphatidylinositol 4-kinase 0.0058 0.033 0.0763
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0084 0.0522 0.0599
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.068 0.0781
Brugia malayi FAT domain containing protein 0.0075 0.045 0.0802
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.016 0.016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0078 0.0473 0.0827
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0122 0.0801 0.0801
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0264 0.0413
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0145 0.0974 0.169
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0031
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0145 0.0974 0.1118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1248 0.2184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0156 0.0155
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0283 0.2 0.5308
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.012
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0058 0.033 0.0329
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0573 0.0573
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1186 0.87 0.87
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0591 0.1001
Brugia malayi PXA domain containing protein 0.002 0.0045 0.0077
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0174 0.1186 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Onchocerca volvulus 0.0048 0.0253 0.0755
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0767 0.5592 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.3378
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.016 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Leishmania major casein kinase II, putative 0.0133 0.0884 0.2329
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0034 0.0039
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0075 0.045 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0168 0.1142 0.1141
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.013
Schistosoma mansoni single-minded 0.0047 0.0247 0.0283
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0059 0.0076
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.016 0.1637
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0145 0.0974 0.0973
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.1097
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0264 0.2701
Loa Loa (eye worm) phosphatidylinositol 3 0.1049 0.7683 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0283 0.2 0.3563
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0573 0.1023
Giardia lamblia Kinase, PLK 0.0186 0.1279 0.4031
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.016 0.0266
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Onchocerca volvulus 0.0058 0.033 0.1117
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.004 0.0196 0.0291
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0034 0.0044
Echinococcus granulosus bloom syndrome protein 0.0021 0.0052 0.0051
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.1279 0.2272
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Plasmodium vivax hypothetical protein 0.0058 0.033 0.3378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0539 0.3896 0.6967
Brugia malayi Pre-SET motif family protein 0.0204 0.1414 0.2526
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.068 0.1198
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0264 0.0413
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0031 0.0127 0.0225
Schistosoma mansoni hypothetical protein 0.0075 0.045 0.0516
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.068 0.068
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.1724
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.2568
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0557 0.4031 0.7192
Echinococcus multilocularis lamin 0.0026 0.0093 0.0092
Schistosoma mansoni lamin 0.0026 0.0093 0.0106
Brugia malayi Cytochrome P450 family protein 0.0029 0.011 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.1447 0.2541
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0166 0.1132 0.13
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0801 0.1431
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Schistosoma mansoni hypothetical protein 0.0094 0.0596 0.0684
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0207 0.1432 0.7109
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0036 0.0038
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0075 0.045 0.0449
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.033 0.3156
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0264 0.0303
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1361 1 1
Echinococcus granulosus casein kinase ii subunit alpha 0.0133 0.0884 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.045 0.0747
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0059
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0031 0.0127 0.0127
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0112 0.0726 0.3514
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0034 0.0039
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0034 0.0059
Echinococcus granulosus expressed protein 0.0363 0.259 0.2589
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0659 0.4787 0.623
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0336 0.0543
Trypanosoma brucei protein kinase, putative 0.005 0.0264 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Entamoeba histolytica protein kinase, putative 0.005 0.0264 0.0413
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1553 0.2732
Schistosoma mansoni fkbp-rapamycin associated protein 0.0122 0.0801 0.092
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.033 0.057
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0036 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0767 0.5592 1
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0127 0.0127
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.3327 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0527 0.0887
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0136 0.0907 0.4435
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0031 0.0127 0.0146
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.016 0.0916
Brugia malayi Pre-SET motif family protein 0.0029 0.0114 0.0201
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.033 0.4554
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0108 0.0616
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0238 0.0272
Toxoplasma gondii FATC domain-containing protein 0.0136 0.0907 0.5179
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.016 0.1637
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0245 0.1718 0.307
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0045 0.0057
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0058 0.033 0.0378
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0034
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0907 0.162
Loa Loa (eye worm) hypothetical protein 0.0045 0.0232 0.0301
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0145 0.0974 0.0973
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0034 0.0039
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis cyclin dependent kinase 19 0.013 0.0861 0.0861
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.033 0.0531
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0396 0.0515
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.009 0.0159
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0283 0.2 0.5308
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0312 0.2214 0.2214
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0312 0.2214 0.3958
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0075 0.045 0.0449
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0145 0.0974 1
Toxoplasma gondii CMGC kinase, CK2 family 0.0133 0.0884 0.5049
Brugia malayi intracellular kinase 0.005 0.0264 0.047
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0247 0.0283
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.3327 0.3326
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0224 0.1558 0.277
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.068 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0061 0.0069
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0573 0.0658
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.0551 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0861 0.0989
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0067
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0336 0.0582
Loa Loa (eye worm) RecQ helicase 0.0021 0.0052 0.0066
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0238 0.0272
Loa Loa (eye worm) gastrulation defective protein 1 0.0127 0.0837 0.1089
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0058 0.033 0.0531
Plasmodium vivax hypothetical protein, conserved 0.0058 0.033 0.3378
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0036 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0282 0.1991 0.9955
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.0039
Brugia malayi hypothetical protein 0.0159 0.1074 0.1918
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.016 0.0227
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0059 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0093 0.012
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0058 0.033 0.0378
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0282 0.1991 0.3521
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0573 0.1023
Onchocerca volvulus 0.0058 0.033 0.1117
Echinococcus multilocularis high voltage activated calcium channel beta 0.0084 0.0522 0.0521
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Giardia lamblia Kinase, CMGC CK2 0.0133 0.0884 0.2672
Loa Loa (eye worm) hypothetical protein 0.0091 0.0573 0.0745
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0282 0.1991 0.3559
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.1604 0.2824
Onchocerca volvulus 0.0035 0.0156 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.068 0.0885
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0061 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.1432 0.2515
Brugia malayi Cytochrome P450 family protein 0.0019 0.0036 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0282 0.1991 0.3547
Echinococcus granulosus tumor protein p63 0.0329 0.2334 0.2334
Leishmania major hypothetical protein, conserved 0.052 0.3758 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1602 0.2084
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0884 0.1529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0557 0.4031 0.7192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0175 0.1198 0.2094
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0058 0.033 0.0378
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.1279 0.2286
Toxoplasma gondii ck2 beta subunit 0.0036 0.016 0.0916
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0031 0.0127 0.0146
Entamoeba histolytica hypothetical protein 0.063 0.4574 0.8169
Echinococcus granulosus single minded 2 0.0035 0.0156 0.0155
Trypanosoma brucei polo-like protein kinase 0.0186 0.1279 0.633
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0052 0.0051
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi Protein kinase domain containing protein 0.013 0.0861 0.1538
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Echinococcus granulosus geminin 0.0166 0.1132 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.1554 0.2733
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0145 0.0974 0.169
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Schistosoma mansoni voltage-gated cation channel 0.0031 0.0127 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.1279 0.224
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0145 0.0974 0.169
Echinococcus multilocularis tumor protein p63 0.0329 0.2334 0.2334
Echinococcus granulosus cyclin dependent kinase 19 0.013 0.0861 0.0861
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0799
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0114 0.0113
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0122 0.0801 0.1415
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0207 0.1432 0.3792
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0355 0.2534 0.4498
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0058 0.033 0.1882
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0245 0.1718 0.1717
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0145 0.0974 0.1724
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0197 0.0226
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.068 0.1785
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0264 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.1751 0.3089
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0224 0.1558 0.2027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi SH2 domain containing protein 0.0659 0.4787 0.856
Plasmodium vivax unspecified product 0.0133 0.0884 0.9082
Brugia malayi 6-phosphofructokinase 0.0106 0.068 0.1215
Leishmania major phosphatidylinositol kinase related protein, putative 0.0073 0.0435 0.1131
Echinococcus multilocularis 0.0058 0.033 0.0329
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1186 0.87 1
Echinococcus granulosus lamin 0.0026 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Echinococcus granulosus lamin dm0 0.0026 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.2 0.3537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1801 0.318
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0974 0.5559
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0573 0.0573
Leishmania major phosphatidylinositol kinase, putative 0.0058 0.033 0.0849
Loa Loa (eye worm) hypothetical protein 0.0078 0.0473 0.0615
Schistosoma mansoni kinase 0.0096 0.0609 0.0699
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Brugia malayi 6-phosphofructokinase 0.0106 0.068 0.1215
Schistosoma mansoni hypothetical protein 0.0158 0.107 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.1355 0.2376
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.0884 0.1529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.033 0.0587
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0396 0.0515
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0127 0.0127
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0034 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0282 0.1991 0.3521
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.3378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0801 0.138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0114 0.0113
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.2 0.2603
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0036 0.0007
Loa Loa (eye worm) hypothetical protein 0.0275 0.1936 0.252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0165
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1623 0.2859
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0336 0.153
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.068 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0396 0.0515
Giardia lamblia Hypothetical protein 0.0058 0.033 0.0763
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Echinococcus multilocularis expressed protein 0.0363 0.259 0.2589
Plasmodium vivax SET domain protein, putative 0.0029 0.0114 0.1157
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.2214 0.2544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0121
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0312 0.2214 0.2881
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1279 0.147
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0019 0.0021
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0034 0.0059
Loa Loa (eye worm) hypothetical protein 0.0462 0.3327 0.433
Onchocerca volvulus 0.005 0.0264 0.0807
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0044
Entamoeba histolytica hypothetical protein 0.0136 0.0907 0.157
Brugia malayi Protein kinase domain containing protein 0.0017 0.0024 0.0041
Schistosoma mansoni lamin 0.0026 0.0093 0.0106
Loa Loa (eye worm) phosphofructokinase 0.0106 0.068 0.0885
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.068 0.068
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.033 0.057
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0133 0.0884 0.9082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) hypothetical protein 0.0069 0.0408 0.0531
Schistosoma mansoni hypothetical protein 0.0058 0.033 0.0378
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0046 0.024 0.0312
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0218
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.068 0.1162
Onchocerca volvulus 0.0045 0.0232 0.0654
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0238 0.0272
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.004 0.0196 0.0291
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0767 0.5592 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0156 0.0178
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0427 0.0427
Toxoplasma gondii hypothetical protein 0.0019 0.0036 0.0207
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0156 0.0276
Entamoeba histolytica hypothetical protein 0.0058 0.033 0.0531
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0767 0.5592 1
Onchocerca volvulus 0.0041 0.0197 0.0491
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0983 0.1278
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0573 0.8335
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0132
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0058 0.033 0.057
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.033 0.0329
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.033 0.0428
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0551 0.0633
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0133 0.0883 0.1149
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0034 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0336 0.0543
Echinococcus multilocularis serine protein kinase ATM 0.0136 0.0907 0.0906
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0133 0.0883 0.5043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0368 0.06
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0046
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.016 0.0184
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0108 0.0616
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0264 0.0263
Onchocerca volvulus 0.0233 0.1624 0.722
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0767 0.5592 1
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0083
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0283 0.2 0.2298
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.1279 0.1279
Loa Loa (eye worm) hypothetical protein 0.0058 0.033 0.0428
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0336 0.0543
Brugia malayi peptidase family M13 containing protein 0.0022 0.0061 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0282 0.0446
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.016 0.0266
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0312 0.2214 0.2214
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.068 0.1162
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.1279 0.1664
Echinococcus multilocularis protein kinase shaggy 0.005 0.0264 0.0263
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.016 0.0227
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0036 0.0007

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.011 ug ml-1 Cytotoxicity of the compound tested against drug sensitive HL60/S cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.018 ug ml-1 Cytotoxicity of the compound tested against drug sensitive HL60/S cell line at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.023 ug ml-1 Cytotoxicity of the compound against drug sensitive HL60/S cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.027 ug ml-1 Cytotoxicity of the compound tested against HL60/Vinc cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.213 ug ml-1 Cytotoxicity of the compound tested against Hela C1 cells at 2.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.224 ug ml-1 Cytotoxicity of the compound tested against drug resistant HL60/ADR cell line at 5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.241 ug ml-1 Cytotoxicity of the compound tested against Hela T5 cells at 2.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.315 ug ml-1 Cytotoxicity of the compound tested against Hela C1 cells at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 0.4440000000000001 ug ml-1 Cytotoxicity of the compound tested against HL60/Vinc cell line at 1 microM dose of LY329146 at 1 uM ChEMBL. 10612603
IC50 (functional) = 1.063 ug ml-1 Cytotoxicity of the compound tested against Hela T5 cells at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.107 ug ml-1 Cytotoxicity of the compound against drug resistant HL60/ADR cell line at 1 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.44 ug ml-1 Cytotoxicity of the compound against HL60/Vinc cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603
IC50 (functional) = 1.715 ug ml-1 Cytotoxicity of the compound tested against drug resistant HL60/ADR cell line at 0.5 microM dose of LY329146 ChEMBL. 10612603

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10612603

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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