TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.996 | Formula: C24H32ClN5O2
H donors: 2 H acceptors: 4 LogP: 2.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)C[C@@H]2O)c1ccc(cc1)Cl)C
InChi: 1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
InChiKey: GRZXWCHAXNAUHY-AHRSYUTCSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 3	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Echinococcus granulosus	alpha tubulin	0.0238	0.1929	0.1924
Trichomonas vaginalis	set domain proteins, putative	0.0204	0.1621	0.8365
Leishmania major	epsilon tubulin, putative	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0131	0.096	0.4961
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0121	0.0596
Brugia malayi	mbt repeat family protein	0.0034	0.0079	0.0377
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0043	0.0166	0.016
Echinococcus multilocularis	neutral alpha glucosidase AB	0.003	0.0042	0.0036
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0211	0.0896
Trypanosoma cruzi	epsilon tubulin, putative	0.0238	0.1929	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0036	0.0102	0.0096
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.0076	0.0363
Treponema pallidum	cell division protein FtsZ	0.0103	0.071	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0084	0.0533	0.0527
Loa Loa (eye worm)	MBCTL1	0.0038	0.0121	0.0596
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Schistosoma mansoni	tubulin subunit gamma	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Entamoeba histolytica	hypothetical protein	0.0456	0.3916	1
Loa Loa (eye worm)	tubulin gamma chain	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Mycobacterium ulcerans	cell division protein FtsZ	0.0103	0.071	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0076	0.007
Leishmania major	alpha tubulin	0.0238	0.1929	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0043	0.0166	0.016
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.003	0.0042	0.0036
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0038	0.0121	0.0115
Mycobacterium leprae	cell division protein FtsZ	0.0103	0.071	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0089	0.0578	0.0572
Mycobacterium ulcerans	DNA polymerase IV	0.0036	0.0102	0.0407
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0036	0.0102	0.0158
Echinococcus granulosus	serine/threonine protein kinase	0.0089	0.0578	0.0572
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0042
Leishmania major	beta tubulin	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.071	0.3657
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0076	0.0363
Entamoeba histolytica	protein kinase, putative	0.0131	0.096	0.2401
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	transcription factor LCR-F1	0.0028	0.0026	0.002
Echinococcus granulosus	tubulin alpha	0.0238	0.1929	0.1924
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0046	0.0189	0.0952
Echinococcus granulosus	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Brugia malayi	beta-lactamase family protein	0.0033	0.0076	0.0363
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Entamoeba histolytica	tubulin gamma chain	0.0238	0.1929	0.4892
Toxoplasma gondii	alpha-tubulin I, putative	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Plasmodium vivax	tubulin beta chain, putative	0.0238	0.1929	1
Schistosoma mansoni	hypothetical protein	0.0032	0.006	0.0053
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0084	0.0533	0.1977
Leishmania major	beta tubulin	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Mycobacterium ulcerans	DNA polymerase IV	0.0036	0.0102	0.0407
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Brugia malayi	alpha-tubulin	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine kinase	0.0043	0.0166	0.016
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Trypanosoma cruzi	zeta tubulin, putative	0.0103	0.071	0.3536
Loa Loa (eye worm)	tubulin alpha 2	0.0134	0.0993	0.5132
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Giardia lamblia	Delta tubulin	0.0103	0.071	0.3325
Echinococcus granulosus	Glutaredoxin protein 5	0.0083	0.0522	0.0516
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0043	0.0166	0.0833
Brugia malayi	Tubulin beta chain	0.0103	0.071	0.3657
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0301	0.153
Trypanosoma cruzi	alpha tubulin, putative	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.071	0.3536
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0043	0.0166	0.016
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Echinococcus multilocularis	protein kinase c epsilon type	0.0043	0.0166	0.016
Leishmania major	alpha tubulin	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Giardia lamblia	Kinase, AGC PKA	0.0084	0.0533	0.2361
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0126	0.0915	0.4727
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0074	0.0169
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0043	0.0166	0.016
Brugia malayi	Cell division protein ftsZ	0.0103	0.071	0.3657
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Echinococcus granulosus	tubulin beta 1 chain	0.0238	0.1929	0.1924
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0238	0.1929	1
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0238	0.1929	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.071	0.3536
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0134	0.0993	0.504
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin, putative	0.0134	0.0993	0.504
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0103	0.071	0.3536
Brugia malayi	Tubulin gamma chain	0.0238	0.1929	1
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.1929	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0036	0.0102	0.0316
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0134	0.0993	0.504
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.1929	1
Echinococcus multilocularis	dna polymerase eta	0.0058	0.0301	0.0294
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	alpha-glucosidase	0.0115	0.0816	0.081
Schistosoma mansoni	tubulin subunit delta	0.0103	0.071	0.0704
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	esterase, putative	0.0033	0.0076	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	tubulin delta chain	0.0103	0.071	0.3678
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0043	0.0166	0.0833
Echinococcus granulosus	polycomb protein SCMH1	0.0034	0.0079	0.0072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0195	0.0189
Echinococcus granulosus	beta tubulin	0.0238	0.1929	0.1924
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0133	0.0976	0.0971
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0036	0.0102	0.0096
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0076	0.0179
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0046	0.0189	0.0952
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0076	0.0179
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0038	0.0121	0.0115
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0084	0.0533	0.2602
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0043	0.0166	0.016
Echinococcus multilocularis	tubulin epsilon chain	0.0238	0.1929	0.1924
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.1929	1
Brugia malayi	Egg laying defective protein 4	0.0046	0.0189	0.0952
Loa Loa (eye worm)	beta-tubulin	0.0238	0.1929	1
Echinococcus granulosus	protein kinase c epsilon type	0.0043	0.0166	0.016
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Trypanosoma brucei	zeta tubulin	0.0103	0.071	0.3678
Leishmania major	alpha tubulin	0.0238	0.1929	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0046	0.0192	0.0966
Echinococcus multilocularis	nervana 2	0.0083	0.0522	0.0516
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Toxoplasma gondii	AGC kinase	0.0126	0.0915	0.4727
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Entamoeba histolytica	protein kinase, putative	0.0131	0.096	0.2401
Echinococcus multilocularis	tubulin alpha	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Brugia malayi	ImpB/MucB/SamB family protein	0.0058	0.0301	0.153
Plasmodium falciparum	tubulin epsilon chain, putative	0.0238	0.1929	1
Trypanosoma cruzi	Protein kinase B	0.0089	0.0578	0.2841
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	beta tubulin	0.0238	0.1929	0.1924
Echinococcus granulosus	dna polymerase eta	0.0058	0.0301	0.0294
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin alpha chain	0.0103	0.071	0.3657
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Schistosoma mansoni	atypical protein kinase C	0.0043	0.0166	0.016
Brugia malayi	Protein kinase domain containing protein	0.0131	0.096	0.4961
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin beta-1 chain	0.0238	0.1929	1
Loa Loa (eye worm)	transcription factor SMAD2	0.011	0.0776	0.4001
Toxoplasma gondii	beta-tubulin, putative	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0043	0.0166	0.0833
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Giardia lamblia	Epsilon tubulin	0.0103	0.071	0.3325
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0084	0.0533	0.2741
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Brugia malayi	Glycosyl hydrolases family 31 protein	0.003	0.0042	0.0187
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0028	0.0026	0.002
Leishmania major	beta tubulin	0.0238	0.1929	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin gamma chain, putative	0.0103	0.071	0.3536
Leishmania major	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Onchocerca volvulus		0.0034	0.0079	0.0449
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus multilocularis	hypothetical protein	0.0238	0.1929	0.1924
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0084	0.0533	0.0527
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0032	0.006	0.0277
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0134	0.0993	0.5132
Schistosoma mansoni	tubulin subunit epsilon	0.0238	0.1929	0.1924
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0034	0.0079	0.0072
Schistosoma mansoni	alpha-glucosidase	0.0115	0.0816	0.081
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Trypanosoma brucei	zeta tubulin, putative	0.0103	0.071	0.3678
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0043	0.0166	0.016
Trypanosoma brucei	tubulin gamma chain	0.0238	0.1929	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0238	0.1929	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Plasmodium falciparum	tubulin delta chain, putative	0.0103	0.071	0.299
Echinococcus multilocularis	peroxisome assembly protein 26	0.0238	0.1929	0.1924
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0089	0.0578	0.2841
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0076	0.0179
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0133	0.0985	0.5088
Echinococcus granulosus	tubulin subunit beta	0.0238	0.1929	0.1924
Entamoeba histolytica	tubulin alpha chain, putative	0.0238	0.1929	0.4892
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Brugia malayi	MH2 domain containing protein	0.011	0.0776	0.4001
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0083	0.0522	0.0516
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Loa Loa (eye worm)	tubulin beta chain	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0189	0.0183
Plasmodium falciparum	tubulin gamma chain	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Giardia lamblia	Alpha-tubulin	0.0238	0.1929	1
Entamoeba histolytica	protein kinase, putative	0.0126	0.0915	0.2286
Entamoeba histolytica	protein kinase 2, putative	0.0084	0.0533	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0377
Trichomonas vaginalis	tubulin, putative	0.0238	0.1929	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0133	0.0985	0.5088
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trypanosoma cruzi	epsilon tubulin, putative	0.0238	0.1929	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.0578	0.1419
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Entamoeba histolytica	tubulin family protein	0.0238	0.1929	0.4892
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0076	0.007
Trypanosoma brucei	glucosidase, putative	0.003	0.0042	0.0219
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Echinococcus multilocularis	beta tubulin	0.0238	0.1929	0.1924
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0028	0.0026	0.002
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0195	0.0982
Echinococcus granulosus	tubulin epsilon chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0103	0.071	0.3657
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0195	0.0189
Leishmania major	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin beta chain	0.0103	0.071	0.3657
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0076	0.0363
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0079	0.0072
Echinococcus granulosus	nervana 2	0.0083	0.0522	0.0516
Entamoeba histolytica	tubulin alpha-1 chain	0.0238	0.1929	0.4892
Schistosoma mansoni	alpha glucosidase	0.003	0.0042	0.0036
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0074	0.0353
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0058	0.0301	0.1558
Brugia malayi	Tubulin alpha chain	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0043	0.0166	0.0833
Plasmodium vivax	delta tubulin, putative	0.0103	0.071	0.3657
Leishmania major	alpha tubulin	0.0238	0.1929	1
Plasmodium falciparum	alpha tubulin 1	0.0238	0.1929	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0034	0.0079	0.0072
Onchocerca volvulus		0.0033	0.0076	0.0432
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0133	0.0976	0.0971
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0043	0.0166	0.016
Leishmania major	alpha tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	BEN-1 protein	0.0238	0.1929	1
Leishmania major	hypothetical protein, conserved	0.0033	0.0076	0.0179
Loa Loa (eye worm)	tubulin alpha 2	0.0134	0.0993	0.5132
Echinococcus granulosus	beta tubulin	0.0238	0.1929	0.1924
Schistosoma mansoni	hypothetical protein	0.0204	0.1629	0.1624
Schistosoma mansoni	serine/threonine-protein kinase	0.0089	0.0578	0.0572
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0036	0.0102	0.0497
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0103	0.071	0.3536
Leishmania major	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus granulosus	dna polymerase kappa	0.0036	0.0102	0.0096
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0079	0.0072
Onchocerca volvulus		0.0033	0.0076	0.0432
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Brugia malayi	tubulin alpha-2 chain	0.0238	0.1929	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0238	0.1929	0.1924
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0083	0.0522	0.0516
Loa Loa (eye worm)	tubulin beta-4 chain	0.0238	0.1929	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0103	0.071	0.3536
Echinococcus granulosus	tubulin subunit TubB	0.0238	0.1929	0.1924
Toxoplasma gondii	alpha tubulin TUBA1	0.0238	0.1929	1
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.1929	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0238	0.1929	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Onchocerca volvulus		0.0204	0.1621	1
Trypanosoma cruzi	beta tubulin, putative	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Echinococcus multilocularis	expressed conserved protein	0.0046	0.0189	0.0183
Leishmania major	DNA polymerase eta, putative	0.0033	0.0074	0.0169
Brugia malayi	Pre-SET motif family protein	0.0179	0.1397	0.723
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0213	0.1707	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0042
Brugia malayi	Hr1 repeat family protein	0.0043	0.0166	0.0833
Plasmodium falciparum	tubulin beta chain	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0043	0.0166	0.0833
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0103	0.071	0.3657
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Toxoplasma gondii	ABC1 family protein	0.0033	0.0076	0.0363
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Giardia lamblia	Alpha-tubulin	0.0238	0.1929	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0034	0.0079	0.0072
Schistosoma mansoni	tubulin subunit alpha	0.0103	0.071	0.0704
Echinococcus granulosus	cGMP dependent protein kinase	0.0046	0.0189	0.0183
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Trypanosoma brucei	hypothetical protein, conserved	0.0033	0.0076	0.0395
Plasmodium vivax	tubulin gamma chain, putative	0.0238	0.1929	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0126	0.0915	0.4727
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	nervana 2	0.0083	0.0522	0.0516
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0187
Leishmania major	DNA polymerase eta, putative	0.0058	0.0301	0.1369
Brugia malayi	Tubulin beta chain	0.0134	0.0993	0.5132
Brugia malayi	beta-lactamase	0.0033	0.0076	0.0363
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0166	0.0833
Loa Loa (eye worm)	MH2 domain-containing protein	0.011	0.0776	0.4001
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0036	0.0102	0.0096
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.0578	0.1419
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0043	0.0166	0.0833
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0038	0.0121	0.0115
Echinococcus multilocularis	tubulin delta chain	0.0103	0.071	0.0704
Toxoplasma gondii	beta tubulin	0.0238	0.1929	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Echinococcus granulosus	NDR protein kinase	0.0043	0.0166	0.016
Plasmodium falciparum	alpha tubulin 2	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Trichomonas vaginalis	tubulin, putative	0.0134	0.0993	0.504
Echinococcus multilocularis	protein kinase c iota type	0.0043	0.0166	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Schistosoma mansoni	DNA polymerase eta	0.0058	0.0301	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.006	0.0277
Trypanosoma brucei	unspecified product	0.0036	0.0102	0.0528
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Leishmania major	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0189	0.0183
Entamoeba histolytica	tubulin family protein	0.0238	0.1929	0.4892
Brugia malayi	protein kinase C II.	0.0043	0.0166	0.0833
Onchocerca volvulus		0.0077	0.0474	0.2897
Onchocerca volvulus		0.0134	0.0993	0.6113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Giardia lamblia	Gamma tubulin	0.0238	0.1929	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0036	0.0102	0.0096
Loa Loa (eye worm)	BEN-1 protein	0.0238	0.1929	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Brugia malayi	beta-lactamase family protein	0.0033	0.0076	0.0363
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.0076	0.007
Trypanosoma cruzi	tubulin delta chain	0.0103	0.071	0.3536
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Echinococcus granulosus	serine threonine protein kinase nrc	0.0084	0.0533	0.0527
Echinococcus granulosus	nervana 2	0.0083	0.0522	0.0516
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0103	0.071	0.3885
Echinococcus multilocularis	tubulin subunit TubB	0.0238	0.1929	0.1924
Trypanosoma cruzi	zeta tubulin, putative	0.0103	0.071	0.3536
Trypanosoma cruzi	DNA polymerase eta, putative	0.0058	0.0301	0.1369
Leishmania major	zeta tubulin, putative	0.0103	0.071	0.3536
Schistosoma mansoni	tubulin subunit beta	0.0103	0.071	0.0704
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0179	0.1397	0.723
Echinococcus granulosus	Protein kinase C brain isozyme	0.0043	0.0166	0.016
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.0076	0.007
Leishmania major	delta tubulin, putative	0.0103	0.071	0.3536
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0993	0.5132
Brugia malayi	ImpB/MucB/SamB family protein	0.0036	0.0102	0.0497
Toxoplasma gondii	beta-1 tubulin, putative	0.0238	0.1929	1
Onchocerca volvulus		0.0033	0.0076	0.0432
Echinococcus granulosus	tubulin delta chain	0.0103	0.071	0.0704
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0195	0.0982
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0038	0.0121	0.0115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0195	0.0189
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0036	0.0102	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0166	0.0833
Entamoeba histolytica	protein kinase, putative	0.0043	0.0166	0.0361
Echinococcus multilocularis	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	serine threonine protein kinase	0.0043	0.0166	0.016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0195	0.0189
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Echinococcus multilocularis	polycomb protein SCMH1	0.0034	0.0079	0.0072
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Brugia malayi	beta-tubulin, identical	0.0238	0.1929	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0103	0.071	0.5
Leishmania major	alpha tubulin	0.0238	0.1929	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0103	0.071	0.3657
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	tubulin beta-1 chain	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Echinococcus multilocularis	dna polymerase kappa	0.0036	0.0102	0.0096
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Loa Loa (eye worm)	mbt repeat family protein	0.0034	0.0079	0.0377
Echinococcus granulosus	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Trypanosoma cruzi	tubulin delta chain	0.0103	0.071	0.3536
Echinococcus granulosus	protein kinase C gamma type	0.0043	0.0166	0.016
Echinococcus multilocularis	tubulin beta 1 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Glutaredoxin protein 5	0.0083	0.0522	0.0516
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0036	0.0102	0.0158
Echinococcus granulosus	tubulin beta 4A class IVa	0.0238	0.1929	0.1924
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0046	0.0192	0.0966
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0166	0.0833
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0238	0.1929	0.1924
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0042	0.0156	0.06
Leishmania major	beta tubulin	0.0238	0.1929	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0038	0.0121	0.0596
Trichomonas vaginalis	tubulin alpha chain, putative	0.0238	0.1929	1
Trypanosoma brucei	alpha tubulin, putative	0.0134	0.0993	0.5148
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0036	0.0102	0.0316
Mycobacterium ulcerans	hypothetical protein	0.0045	0.0178	0.1615
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Echinococcus granulosus	protein kinase c iota type	0.0043	0.0166	0.016
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0192	0.0966
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0089	0.0578	0.0572
Trichomonas vaginalis	tubulin, putative	0.0103	0.071	0.3536
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.003	0.0042	0.0187
Trichomonas vaginalis	tubulin beta chain, putative	0.0134	0.0993	0.504
Brugia malayi	tubulin alpha chain - mouse	0.0238	0.1929	1
Brugia malayi	mbt repeat family protein	0.0034	0.0079	0.0377
Echinococcus multilocularis	tubulin gamma 1 chain	0.0238	0.1929	0.1924
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Brugia malayi	hypothetical protein	0.0028	0.0026	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0046	0.0192	0.0966
Trypanosoma cruzi	tubulin gamma chain	0.0238	0.1929	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0038	0.0121	0.0115
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0076	0.0363
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0034	0.0079	0.0449
Schistosoma mansoni	hypothetical protein	0.0028	0.0026	0.002
Trichomonas vaginalis	DNA polymerase eta, putative	0.0036	0.0102	0.0316
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0076	0.0179
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0131	0.096	0.4978
Leishmania major	gamma-tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.1929	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0043	0.0166	0.016
Leishmania major	beta tubulin	0.0238	0.1929	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 68 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluorescence labeled substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 73 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluorescence labeled Crosstide as substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 249 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluorescence labeled substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 740 nM	Inhibition of Akt1 in human LNCAP cells assessed as phosphorylation of PRAS40 at Thr246 after 1.5 hrs	ChEMBL.	22934575

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177380

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1723652