TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 922.036 | Formula: C48H59N9O10
H donors: 11 H acceptors: 10 LogP: 1.57 Rotable bonds: 32
Rule of 5 violations (Lipinski): 3
SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)NCC(=O)N[C@H](C(=O)N)Cc1ccccc1)C)Cc1ccc(cc1)O)Cc1ccccc1)CNC(=O)C[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)C
InChi: 1S/C48H59N9O10/c1-29(53-46(65)37(49)23-33-13-17-35(58)18-14-33)21-41(60)52-28-44(63)56-39(25-32-11-7-4-8-12-32)48(67)57-40(26-34-15-19-36(59)20-16-34)47(66)54-30(2)22-42(61)51-27-43(62)55-38(45(50)64)24-31-9-5-3-6-10-31/h3-20,29-30,37-40,58-59H,21-28,49H2,1-2H3,(H2,50,64)(H,51,61)(H,52,60)(H,53,65)(H,54,66)(H,55,62)(H,56,63)(H,57,67)/t29-,30-,37+,38+,39+,40+/m1/s1
InChiKey: AZMWAHGYNUNWBB-KPPTUHEKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Delta opioid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Mu opioid receptor	Starlite/ChEMBL	References
Cavia porcellus	Mu opioid receptor	Starlite/ChEMBL	References
Mus musculus	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Mu opioid receptor	98 aa	100 aa	25.0 %
Schistosoma mansoni	thyrotropin-releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	27.0 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Mu opioid receptor	98 aa	85 aa	32.9 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	93 aa	30.1 %
Onchocerca volvulus		Delta opioid receptor	372 aa	353 aa	21.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	24.7 %
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Echinococcus multilocularis	serotonin receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	87 aa	32.2 %
Schistosoma mansoni	opsin-like receptor	Mu opioid receptor	98 aa	80 aa	25.0 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Mu opioid receptor	98 aa	97 aa	36.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	28.1 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	81 aa	34.6 %
Brugia malayi	GnHR receptor homolog	Delta opioid receptor	372 aa	313 aa	18.5 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Mu opioid receptor	98 aa	80 aa	23.8 %
Schistosoma japonicum	Neuropeptide Y receptor type 2, putative	Mu opioid receptor	98 aa	79 aa	31.6 %
Onchocerca volvulus		Delta opioid receptor	372 aa	349 aa	22.1 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Mu opioid receptor	398 aa	334 aa	23.1 %
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	Mu opioid receptor	98 aa	99 aa	36.4 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Mu opioid receptor	98 aa	79 aa	36.7 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Echinococcus granulosus	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Loa Loa (eye worm)	neuropeptide F receptor	Delta opioid receptor	372 aa	317 aa	23.3 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	81 aa	35.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	35.0 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Delta opioid receptor	372 aa	320 aa	25.6 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	90 aa	28.9 %
Onchocerca volvulus		Mu opioid receptor	98 aa	86 aa	33.7 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Mu opioid receptor	98 aa	92 aa	21.7 %
Echinococcus multilocularis	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	98 aa	31.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	21.5 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Mu opioid receptor	98 aa	92 aa	32.6 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Mu opioid receptor	98 aa	97 aa	37.1 %
Schistosoma japonicum	Rhodopsin, putative	Mu opioid receptor	398 aa	328 aa	23.2 %
Schistosoma mansoni	growth hormone secretagogue receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	88 aa	39.8 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Delta opioid receptor	372 aa	366 aa	22.7 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	79 aa	29.1 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	98 aa	37.8 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Schistosoma japonicum	ko:K04282 thyrotropin-releasing hormone receptor, putative	Mu opioid receptor	98 aa	100 aa	28.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	25.9 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Mu opioid receptor	98 aa	98 aa	34.7 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Mu opioid receptor	98 aa	85 aa	25.9 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Mu opioid receptor	98 aa	80 aa	28.8 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	24.0 %
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	31.5 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	93 aa	25.8 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	98 aa	35.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	93 aa	36.6 %
Onchocerca volvulus	Phospholipase d-related homolog	Mu opioid receptor	98 aa	82 aa	25.6 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	398 aa	335 aa	20.6 %
Echinococcus multilocularis	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Mu opioid receptor	98 aa	79 aa	34.2 %
Schistosoma japonicum	FMRFamide receptor, putative	Mu opioid receptor	98 aa	109 aa	28.4 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Brugia malayi	G protein-coupled receptor	Mu opioid receptor	98 aa	90 aa	31.1 %
Schistosoma japonicum	Muscarinic acetylcholine receptor M1, putative	Mu opioid receptor	98 aa	95 aa	30.5 %
Echinococcus granulosus	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	88 aa	23.9 %
Schistosoma mansoni	hypothetical protein	Mu opioid receptor	98 aa	100 aa	23.0 %
Brugia malayi	Melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	33.3 %
Schistosoma mansoni	amine GPCR	Mu opioid receptor	98 aa	86 aa	32.6 %
Echinococcus multilocularis	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	38.2 %
Brugia malayi	ORL1-like opioid receptor	Delta opioid receptor	372 aa	300 aa	24.7 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	97 aa	38.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	101 aa	20.8 %
Onchocerca volvulus		Delta opioid receptor	372 aa	386 aa	22.8 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Mu opioid receptor	398 aa	397 aa	22.7 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	40.4 %
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	Mu opioid receptor	98 aa	80 aa	37.5 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Mu opioid receptor	98 aa	93 aa	33.3 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Mu opioid receptor	98 aa	80 aa	31.2 %
Onchocerca volvulus		Delta opioid receptor	372 aa	344 aa	22.1 %
Loa Loa (eye worm)	melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	36.1 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	96 aa	31.2 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Echinococcus multilocularis	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	28.5 %
Echinococcus granulosus	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	27.8 %
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Loa Loa (eye worm)	TYRA-2 protein	Mu opioid receptor	98 aa	87 aa	31.0 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	91 aa	38.5 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	34.0 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Mu opioid receptor	98 aa	96 aa	31.2 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.2 %
Echinococcus granulosus	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Brugia malayi	larval opioid receptor	Mu opioid receptor	98 aa	100 aa	24.0 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	85 aa	37.6 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Delta opioid receptor	372 aa	315 aa	28.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	88 aa	37.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	23.9 %
Onchocerca volvulus		Delta opioid receptor	372 aa	316 aa	26.9 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Mu opioid receptor	98 aa	96 aa	32.3 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	100 aa	29.0 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Delta opioid receptor	372 aa	353 aa	29.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	31.6 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Echinococcus multilocularis	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma japonicum	Probable G-protein coupled receptor No9, putative	Mu opioid receptor	98 aa	95 aa	28.4 %
Schistosoma mansoni	adenoreceptor	Mu opioid receptor	98 aa	88 aa	38.6 %
Onchocerca volvulus	Programmed cell death protein 5 homolog	Mu opioid receptor	398 aa	323 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0088	0.0088
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0018	0.0081	0.0081
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0032	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0032	0.0032
Schistosoma mansoni	importin beta-1	0.003	0.0179	0.0227
Echinococcus multilocularis	activated cdc42 kinase 1	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK/RYK protein kinase	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0018	0.0081	0.022
Echinococcus multilocularis	protein kinase	0.0018	0.0081	0.0081
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0175	0.0221
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.0032	0.004
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK/ACK protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0018	0.0081	0.0081
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK/Met protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	c src tyrosine kinase	0.0018	0.0081	0.0081
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.013	0.0978	0.6323
Entamoeba histolytica	hypothetical protein	0.0035	0.0223	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0018	0.0081	0.0081
Brugia malayi	Stress-activated protein kinase jnk-1	0.0998	0.7899	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0018	0.0081	0.0081
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0032	0.0032
Echinococcus granulosus	tyrosine protein kinase Blk	0.0018	0.0081	0.0081
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Entamoeba histolytica	protein kinase, putative	0.0018	0.0081	0.00000069082
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0018	0.0081	0.0081
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.1801	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Onchocerca volvulus		0.0018	0.0081	0.022
Brugia malayi	hypothetical protein	0.024	0.1858	0.2352
Echinococcus granulosus	mitogen activated protein kinase 14	0.013	0.0978	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	snurportin 1	0.032	0.2493	0.2493
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0032	0.004
Echinococcus granulosus	tyrosine kinase	0.0018	0.0081	0.0081
Echinococcus granulosus	activin receptor type	0.002	0.01	0.01
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0071	0.0071
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0179	0.1166
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0018	0.0081	0.022
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0032	0.0032
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0032	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0032	0.0032
Brugia malayi	S-adenosyl-methionine cycloartenol-C24-methyltransferase	0.0095	0.07	0.0886
Schistosoma mansoni	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0032	0.0032
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0018	0.0081	0.0081
Leishmania major	GTP-binding protein, putative	0.0022	0.0116	0.025
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0018	0.0081	0.0102
Entamoeba histolytica	hypothetical protein	0.0035	0.0223	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0018	0.0081	0.0081
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0146	0.0184
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0011	0.0032	0.004
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0088	0.5
Echinococcus granulosus	c-Jun N-terminal kinases	0.0998	0.7899	0.7899
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	tyrosine kinase	0.0018	0.0081	0.0081
Onchocerca volvulus		0.0018	0.0081	0.022
Brugia malayi	Dopamine receptor protein 1	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0018	0.0081	0.022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Onchocerca volvulus		0.0011	0.0032	0.0087
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0175	0.9534
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Schistosoma mansoni	opsin-like receptor	0.0011	0.0032	0.004
Onchocerca volvulus		0.0018	0.0081	0.022
Brugia malayi	Raf kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0018	0.0081	0.0102
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0116	1
Loa Loa (eye worm)	SRC-1	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Brugia malayi	GnHR receptor homolog	0.0011	0.0032	0.004
Entamoeba histolytica	hypothetical protein	0.0035	0.0223	1
Echinococcus multilocularis	mitogen activated protein kinase 11	0.013	0.0978	0.0978
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0032	0.0032
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0018	0.0081	0.0081
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0018	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.032	0.2493	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0018	0.0081	0.000000057095
Plasmodium falciparum	protein kinase, putative	0.002	0.01	0.1992
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/ROR protein kinase	0.0018	0.0081	0.0102
Entamoeba histolytica	hypothetical protein	0.0035	0.0223	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.0032	0.004
Onchocerca volvulus		0.0018	0.0081	0.022
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Onchocerca volvulus		0.0018	0.0081	0.022
Onchocerca volvulus		0.0233	0.1801	0.4902
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0018	0.0081	0.0102
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0018	0.0081	0.0081
Entamoeba histolytica	hypothetical protein	0.0024	0.0134	0.3758
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Brugia malayi	RE15519p	0.0011	0.0032	0.004
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.013	0.0978	0.1238
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0088	0.074
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	mitogen activated protein kinase 11	0.013	0.0978	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	receptor type guanylyl cyclase	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0032	0.0032
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.0032	0.004
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0179	0.1166
Echinococcus granulosus	tyrosine protein kinase HCK	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	serine/threonine protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0032	0.004
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0018	0.0081	0.0102
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0071	0.0071
Onchocerca volvulus	Tyrosine kinase homolog	0.0018	0.0081	0.022
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0032	0.0032
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0354	0.0448
Schistosoma mansoni	protein kinase	0.002	0.01	0.0127
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0088	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	activin receptor type	0.002	0.01	0.01
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0032	0.0032
Echinococcus granulosus	tyrosine protein kinase Lyn	0.002	0.01	0.01
Echinococcus granulosus	tyrosine kinase	0.0018	0.0081	0.0081
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.003	0.0179	0.0227
Brugia malayi	G protein-coupled receptor	0.0011	0.0032	0.004
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0134	0.0377
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.1858	0.1858
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0071	0.009
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0018	0.0081	0.0081
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Brugia malayi	sulfakinin receptor protein	0.0011	0.0032	0.004
Schistosoma mansoni	ephrin receptor	0.0018	0.0081	0.0102
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.002	0.01	0.1992
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0032	0.004
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0116	0.3602
Echinococcus multilocularis	geminin	0.0349	0.272	0.272
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0032	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Schistosoma mansoni	ap endonuclease	0.0019	0.0088	0.0111
Brugia malayi	follicle stimulating hormone receptor	0.0011	0.0032	0.004
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0088	0.0554
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0134	0.0311
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.0032	0.004
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0223	0.0282
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.002	0.01	0.0139
Echinococcus multilocularis	serotonin receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.0032	0.004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0032	0.0032
Echinococcus multilocularis	epidermal growth factor receptor	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0018	0.0081	0.0081
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.013	0.0978	0.6509
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0175	0.0221
Echinococcus granulosus	epidermal growth factor receptor	0.0018	0.0081	0.0081
Schistosoma mansoni	serine/threonine protein kinase	0.0998	0.7899	1
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0032	0.0032
Echinococcus granulosus	integrin linked protein kinase	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus granulosus	somatostatin receptor	0.0011	0.0032	0.0032
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0018	0.0081	0.0081
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0032	0.004
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0018	0.0081	0.022
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.013	0.0978	0.6323
Echinococcus granulosus	protein kinase	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Brugia malayi	ORL1-like opioid receptor	0.0011	0.0032	0.004
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0116	0.025
Onchocerca volvulus		0.0018	0.0081	0.022
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	protein tyrosine kinase	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0011	0.0032	0.0087
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0088	0.074
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0018	0.0081	0.0081
Echinococcus granulosus	tyrosine protein kinase Srms	0.0018	0.0081	0.0081
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus multilocularis	tyrosine kinase	0.0018	0.0081	0.0081
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0116	0.3602
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0011	0.0032	0.0087
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Trichomonas vaginalis	ran, putative	0.0022	0.0116	0.0207
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0018	0.0081	0.022
Loa Loa (eye worm)	TK/FAK protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	G-protein coupled receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0018	0.0081	0.0081
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0018	0.0081	0.022
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0088	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0032	0.004
Brugia malayi	RNA, U transporter 1	0.0085	0.062	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Plasmodium falciparum	importin beta, putative	0.003	0.0179	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0018	0.0081	0.0081
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Brugia malayi	SH2 domain containing protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0088	0.0514
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0032	0.0032
Brugia malayi	Melatonin receptor type 1A	0.0011	0.0032	0.004
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0071	0.0071
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0221
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0018	0.0081	0.0081
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0018	0.0081	0.0081
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0032	0.0032
Brugia malayi	putative neuropeptide receptor	0.0011	0.0032	0.004
Schistosoma mansoni	protein kinase	0.002	0.01	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0018	0.0081	0.000000057095
Onchocerca volvulus		0.0011	0.0032	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	protein tyrosine kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0032	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	heat shock protein 70	0.0018	0.0081	0.0081
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0018	0.0081	0.0081
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0032	0.004
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0018	0.0081	0.000000057095
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0018	0.0081	0.0081
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0032	0.004
Schistosoma mansoni	myosin xvIII	0.0011	0.0032	0.004
Schistosoma mansoni	opsin-like receptor	0.0011	0.0032	0.004
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	importin subunit beta 1	0.003	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Onchocerca volvulus		0.0011	0.0032	0.0087
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0088	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0116	0.025
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0018	0.0081	0.0102
Echinococcus granulosus	geminin	0.0349	0.272	0.272
Echinococcus multilocularis	mitogen activated protein kinase 11	0.013	0.0978	0.0978
Echinococcus multilocularis	tyrosine kinase	0.0018	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.0016	0.0071	0.009
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0146	0.0184
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	serotonin receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	TK/ALK protein kinase	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.013	0.0978	0.6323
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	TK/EPH protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	vesicular acetylcholine transporter	0.0468	0.3674	0.4651
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0116	0.0147
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	amine GPCR	0.0011	0.0032	0.004
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.1575	0.1994
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0223	0.0223
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0088	0.0051
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	amine GPCR	0.0011	0.0032	0.004
Onchocerca volvulus		0.0018	0.0081	0.022
Loa Loa (eye worm)	hypothetical protein	0.024	0.1858	0.2352
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0018	0.0081	0.022
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	epidermal growth factor receptor	0.0018	0.0081	0.0081
Brugia malayi	larval opioid receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/INSR protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0032	0.004
Brugia malayi	neuropeptide F receptor	0.0011	0.0032	0.004
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0018	0.0081	0.0081
Echinococcus granulosus	sex peptide receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0032	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Schistosoma mansoni	amine GPCR	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0018	0.0081	0.0081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0049	0.0331	0.0902
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0018	0.0081	0.0081
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0354	0.0448
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Brugia malayi	SH2 domain containing protein	0.0018	0.0081	0.0102
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0032	0.0032
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0175	0.0175
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0018	0.0081	0.0081
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0179	0.0179
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0032	0.0032
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0018	0.0081	0.0102
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0071	0.009
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0032	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Trichomonas vaginalis	TKL family protein kinase	0.0018	0.0081	0.000000057095
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	protein kinase	0.002	0.01	0.0127
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.002	0.01	0.01
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0018	0.0081	0.0102
Echinococcus multilocularis	transfer RNA-Thr	0.0018	0.0081	0.0081
Echinococcus multilocularis	protein kinase	0.0018	0.0081	0.0081
Echinococcus granulosus	hypothetical protein	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	insulin receptor	0.0018	0.0081	0.0081
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0998	0.7899	0.7899
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Entamoeba histolytica	protein kinase, putative	0.0018	0.0081	0.00000069082
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0032	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Brugia malayi	Serotonin receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0071	0.0071
Schistosoma mansoni	histamine h1 receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0032	0.0032
Brugia malayi	Receptor family ligand binding region containing protein	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0116	0.0743
Brugia malayi	ephrin receptor 1 precursor	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0088	0.0042
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0116	0.0116
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0032	0.004
Brugia malayi	hypothetical protein	0.0035	0.0223	0.0282
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0032	0.0032
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0011	0.0032	0.0087
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0223	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.0032	0.004
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0011	0.0032	0.0087
Schistosoma mansoni	ran	0.0022	0.0116	0.0147
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0223	0.0282
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.0032	0.004
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	neuropeptide F receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.002	0.01	0.0139
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0175	0.0175
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0166	0.0166
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0088	0.5
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0035	0.0223	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0116	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	protein tyrosine kinase	0.0018	0.0081	0.0081
Brugia malayi	C-terminal src kinase protein 1	0.0018	0.0081	0.0102
Schistosoma mansoni	adenoreceptor	0.0011	0.0032	0.004
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0032	0.0032
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0116	0.3602
Brugia malayi	P38 map kinase family protein 2	0.013	0.0978	0.1238
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0018	0.0081	0.0081
Schistosoma mansoni	ran	0.0022	0.0116	0.0147
Brugia malayi	Pre-SET motif family protein	0.0205	0.1575	0.1994
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.0032	0.004
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0032	0.0032
Echinococcus multilocularis	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.0032	0.004
Schistosoma mansoni	serine/threonine RGC	0.0018	0.0081	0.0102
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0102	0.0753	0.5007
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.002	0.01	0.01
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0018	0.0081	0.0102
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0088	0.0051
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0179	1
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus granulosus	c src tyrosine kinase	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Schistosoma mansoni	ephrin receptor	0.0018	0.0081	0.0102
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0071	0.0071
Brugia malayi	protein-tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	serotonin receptor	0.0011	0.0032	0.0032
Brugia malayi	Pre-SET motif family protein	0.0029	0.0175	0.0221
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0018	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.0016	0.0071	0.009
Trypanosoma brucei	protein kinase, putative	0.002	0.01	0.0637
Schistosoma mansoni	hypothetical protein	0.0349	0.272	0.3443
Brugia malayi	Dopamine receptor protein 2	0.0011	0.0032	0.004
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.0032	0.004
Brugia malayi	integrin-linked kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	mitogen activated protein kinase 14	0.013	0.0978	0.0978
Onchocerca volvulus		0.0011	0.0032	0.0087
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0032	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0049	0.0331	0.0419
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Onchocerca volvulus		0.0018	0.0081	0.022
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0018	0.0081	0.0102
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0018	0.0081	0.0081
Schistosoma mansoni	ap endonuclease	0.0019	0.0088	0.0111
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0088	0.0088
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.032	0.2493	0.3156
Echinococcus multilocularis	snurportin 1	0.032	0.2493	0.2493
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	activated cdc42 kinase 1	0.0018	0.0081	0.0081
Plasmodium vivax	SET domain protein, putative	0.0029	0.0175	0.9534
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.0032	0.004
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0032	0.0032
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0018	0.0081	0.022
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Brugia malayi	Tyrosine-protein kinase abl-1	0.0018	0.0081	0.0102
Echinococcus multilocularis	insulin receptor	0.0018	0.0081	0.0081
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0134	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0095	0.07	0.0886
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0032	0.004
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0175	0.0221
Brugia malayi	SRC-1	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus granulosus	natriuretic peptide receptor 1	0.0018	0.0081	0.0081
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0331	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0018	0.0081	0.0081
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0088	0.2055
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	opsin-like receptor	0.0011	0.0032	0.004
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Leishmania major	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0468	0.3674	0.4651
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0088	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0032	0.0032
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0223	0.0223
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0018	0.0081	0.0081
Onchocerca volvulus		0.0018	0.0081	0.022
Entamoeba histolytica	ankyrin repeat protein	0.0018	0.0081	0.00000069082
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0032	0.0032
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	hypothetical protein	0.0349	0.272	0.3443
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0018	0.0081	0.0081
Echinococcus granulosus	GPCR family 2	0.0016	0.0071	0.0071
Entamoeba histolytica	Ran family GTPase	0.0022	0.0116	0.2499
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0032	0.0032
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0018	0.0081	0.0506
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0032	0.004
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0018	0.0081	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0032	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0035	0.0223	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	amine GPCR	0.0011	0.0032	0.004
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0088	0.0042
Leishmania major	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0331	0.0419
Giardia lamblia	Kinase, NEK	0.0018	0.0081	0.0000027643
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0032	0.0032
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0032	0.004
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Leishmania major	protein kinase, putative	0.002	0.01	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Schistosoma mansoni	hypothetical protein	0.0016	0.0071	0.009
Onchocerca volvulus		0.0029	0.0175	0.0476
Echinococcus multilocularis	integrin linked protein kinase	0.0018	0.0081	0.0081
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0032	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0018	0.0081	0.0102
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0134	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0088	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0018	0.0081	0.0081
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0468	0.3674	1
Onchocerca volvulus		0.0011	0.0032	0.0087
Entamoeba histolytica	protein kinase domain containing protein	0.002	0.01	0.1382
Echinococcus granulosus	tyrosine protein kinase pr2	0.0018	0.0081	0.0081
Echinococcus granulosus	raf serine:threonine protein kinase	0.0018	0.0081	0.0081
Brugia malayi	Serotonin receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.009
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0032	0.0032
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0354	0.0448
Echinococcus granulosus	tyrosine protein kinase shark	0.0018	0.0081	0.0081
Echinococcus granulosus	tyrosine protein kinase	0.0018	0.0081	0.0081
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0032	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0175	0.0221
Schistosoma mansoni	hypothetical protein	0.0016	0.0071	0.009
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0081	0.0102
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0032	0.004
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0196	0.15	1
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0018	0.0081	0.0081
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0018	0.0081	0.0081
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0032	0.0032
Plasmodium vivax	importin-beta 2, putative	0.003	0.0179	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.0032	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0998	0.7899	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	Guanylyl cyclase protein 23	0.0018	0.0081	0.0102
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0032	0.0032
Onchocerca volvulus		0.0011	0.0032	0.0087
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.0032	0.004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/CSK protein kinase	0.0018	0.0081	0.0102
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.002	0.01	0.0637
Trichomonas vaginalis	TKL family protein kinase	0.0018	0.0081	0.000000057095
Echinococcus multilocularis	FL cytokine receptor	0.0018	0.0081	0.0081
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase shark	0.0018	0.0081	0.0081
Brugia malayi	AKH receptor	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus granulosus	epidermal growth factor receptor	0.0018	0.0081	0.0081
Brugia malayi	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.0032	0.004
Echinococcus granulosus	tyrosine protein kinase csk	0.0018	0.0081	0.0081
Trypanosoma brucei	Pseudokinase, putative	0.0018	0.0081	0.0506
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0081	0.0102
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.0032	0.004
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0032	0.004
Giardia lamblia	Protein 21.1	0.0018	0.0081	0.0000027643
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.0032	0.004
Loa Loa (eye worm)	TK/DDR protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0081	0.0081
Echinococcus granulosus	activated cdc42 kinase 1	0.0018	0.0081	0.0081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Brugia malayi	Importin beta-1 subunit	0.003	0.0179	0.0227
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Toxoplasma gondii	exonuclease III APE	0.0019	0.0088	0.074
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0081	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0071	0.009
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.1858	0.1858
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0032	0.004
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0018	0.0081	0.0506
Schistosoma mansoni	amine GPCR	0.0011	0.0032	0.004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Brugia malayi	Furin-like cysteine rich region family protein	0.0018	0.0081	0.0102
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0134	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0032	0.004
Trypanosoma brucei	Sterol methyltransferase, putative	0.0196	0.15	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0018	0.0081	0.0081
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0468	0.3674	0.4651
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0018	0.0081	0.0081
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	vesicular acetylcholine transporter	0.0468	0.3674	0.3674
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0011	0.0032	0.0087
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0018	0.0081	0.0081
Schistosoma mansoni	protein kinase	0.0018	0.0081	0.0102
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0018	0.0081	0.0081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0032	0.0032
Brugia malayi	G-protein coupled receptor	0.0011	0.0032	0.004
Echinococcus multilocularis	mitogen activated protein kinase 14	0.013	0.0978	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0102
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0032	0.0032
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0354	0.0448
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0468	0.3674	0.3674
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0032	0.0032
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0018	0.0081	0.0081
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0018	0.0081	0.0081
Brugia malayi	Dopamine receptor	0.0011	0.0032	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0032	0.004
Brugia malayi	Tyrosine-protein kinase PR2	0.0018	0.0081	0.0102
Schistosoma mansoni	tyrosine kinase	0.0018	0.0081	0.0102

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.9	Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis	ChEMBL.	23547584
IC50 (binding)	= 8.75	Displacement of [3H]Deltorphin from DOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis	ChEMBL.	23547584
IC50 (binding)	= 1700 nM	Inhibition of MOR in Hartley guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of electrically-stimulated muscle contraction after 3 mins	ChEMBL.	23547584
IC50 (binding)	= 1800 nM	Inhibition of DOR in ICR mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction after 3 mins	ChEMBL.	23547584
Ki (binding)	= 57 nM	Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis	ChEMBL.	23547584
Ki (binding)	= 450 nM	Displacement of [3H]Deltorphin from DOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis	ChEMBL.	23547584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323575

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1728080