TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.498 | Formula: C23H30N2
H donors: 0 H acceptors: 0 LogP: 5.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCn1c2ccc(cc2c2c1cccc2)CN1CCCCC1
InChi: 1S/C23H30N2/c1-2-3-7-16-25-22-11-6-5-10-20(22)21-17-19(12-13-23(21)25)18-24-14-8-4-9-15-24/h5-6,10-13,17H,2-4,7-9,14-16,18H2,1H3
InChiKey: NTCPKTSBLCDRJZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0451	0.0451
Echinococcus multilocularis	oxysterol binding protein 9	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	beta-lactamase	0.0036	0.0225	0.078
Entamoeba histolytica	hypothetical protein	0.016	0.1164	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0354	0.0354
Schistosoma mansoni	regulator of G protein signaling	0.016	0.1164	0.1164
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0033	0.0204	0.106
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0033	0.0204	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0082	0.0285
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Brugia malayi	Cadps2 protein	0.0029	0.0175	0.0606
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Trichomonas vaginalis	centaurin/arf, putative	0.0029	0.0175	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Onchocerca volvulus		0.0036	0.0225	0.1217
Loa Loa (eye worm)	Plekhf2 protein	0.0029	0.0175	0.0175
Brugia malayi	Muscleblind-like protein	0.0152	0.1108	0.384
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0022	0.0022
Onchocerca volvulus		0.0029	0.0175	0.0944
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0082	0.0285
Echinococcus multilocularis	rac serine:threonine kinase	0.0033	0.0204	0.0204
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.02	0.02
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0036	0.0036
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0033	0.0204	0.5754
Schistosoma mansoni	axis inhibition protein axin	0.016	0.1164	0.1164
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0228	0.1679	0.1679
Brugia malayi	beta-lactamase family protein	0.0036	0.0225	0.078
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0022
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0033	0.0204	0.5754
Trichomonas vaginalis	centaurin beta, putative	0.0029	0.0175	0.0903
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0225	1
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0029	0.0175	0.0175
Entamoeba histolytica	hypothetical protein	0.016	0.1164	1
Schistosoma mansoni	regulator of G protein signaling	0.016	0.1164	0.1164
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0298
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0022	0.0022
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0029	0.0175	0.0175
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.1673	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0225	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1328	1	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0029	0.0175	0.0903
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0082	0.0082
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1168	0.8793	0.8793
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0029	0.0175	0.0903
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0029	0.0175	0.0175
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Echinococcus granulosus	Pleckstrin y	0.0029	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	Dynamin	0.0029	0.0175	0.0606
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0033	0.0204	0.5754
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0029	0.0175	0.0175
Schistosoma mansoni	regulator of G protein signaling	0.016	0.1164	0.1164
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0228	0.1679	0.1679
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0033	0.0204	0.1293
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0029	0.0175	0.0175
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0033	0.0204	0.5754
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0225	0.5
Schistosoma mansoni	axis inhibition protein axin	0.016	0.1164	0.1164
Schistosoma mansoni	cpg binding protein	0.0032	0.0199	0.0199
Onchocerca volvulus		0.0029	0.0175	0.0944
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0354	0.1227
Schistosoma mansoni	hypothetical protein	0.0017	0.0082	0.0082
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0029	0.0175	0.0903
Brugia malayi	hypothetical protein	0.016	0.1164	0.4032
Brugia malayi	regulator of G-protein signaling egl-10	0.016	0.1164	0.4032
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Onchocerca volvulus		0.003	0.0186	0.1003
Brugia malayi	Regulator of G protein signaling domain containing protein	0.016	0.1164	0.4032
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	Pre-SET motif family protein	0.0032	0.02	0.0692
Brugia malayi	Variant SH3 domain containing protein	0.0029	0.0175	0.0606
Echinococcus multilocularis	actin binding protein anillin	0.0029	0.0175	0.0175
Schistosoma mansoni	syntrophin	0.0029	0.0175	0.0175
Leishmania major	folate/biopterin transporter, putative	0.0033	0.0204	0.5754
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0029	0.0175	0.0606
Echinococcus granulosus	Rho GTPase activating protein 24	0.0029	0.0175	0.0175
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0225	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Echinococcus multilocularis	myotubularin protein 13	0.0029	0.0175	0.0175
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0036	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Schistosoma mansoni	rho gtpase activating protein	0.0029	0.0175	0.0175
Brugia malayi	beta-lactamase family protein	0.0036	0.0225	0.078
Trypanosoma cruzi	Protein kinase B	0.0033	0.0204	0.5754
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0298
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0029	0.0175	0.0175
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Onchocerca volvulus		0.0029	0.0175	0.0944
Loa Loa (eye worm)	oxysterol binding protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0029	0.0175	0.0175
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.016	0.1164	0.1164
Echinococcus multilocularis	Pleckstrin y	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0033	0.0204	0.5754
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0225	0.5
Echinococcus multilocularis	Oxysterol binding protein 11	0.0029	0.0175	0.0175
Echinococcus granulosus	pdz domain containing protein	0.0029	0.0175	0.0175
Toxoplasma gondii	protein kinase domain-containing protein	0.0033	0.0204	0.1293
Echinococcus multilocularis	Regulator of G protein signaling 20	0.016	0.1164	0.1164
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trichomonas vaginalis	kinesin light chain, putative	0.0029	0.0175	0.0903
Onchocerca volvulus		0.0036	0.0225	0.1217
Echinococcus granulosus	regulator of G protein signaling 7	0.016	0.1164	0.1164
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0225	0.0225
Brugia malayi	hypothetical protein	0.0029	0.0175	0.0606
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0033	0.0204	0.5754
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Echinococcus granulosus	pleckstrin y domain containing family A	0.0029	0.0175	0.0175
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Leishmania major	protein kinase, putative	0.0033	0.0204	0.5754
Brugia malayi	Cytohesin 3	0.0029	0.0175	0.0606
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0029	0.0175	0.0175
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0029	0.0175	0.0606
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0082	0.0082
Brugia malayi	regulator of G-protein signaling rgs-7	0.016	0.1164	0.4032
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Schistosoma mansoni	centaurin alpha	0.0029	0.0175	0.0175
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Brugia malayi	MAX-1A	0.0029	0.0175	0.0606
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0298	0.1032
Trichomonas vaginalis	protein transport protein sec7, putative	0.0029	0.0175	0.0903
Echinococcus granulosus	Pleckstrin y	0.0029	0.0175	0.0175
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1328	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trichomonas vaginalis	centaurin gamma, putative	0.0029	0.0175	0.0903
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Onchocerca volvulus	Protein melted homolog	0.0029	0.0175	0.0944
Schistosoma mansoni	goodpasture antigen-binding protein	0.0029	0.0175	0.0175
Brugia malayi	Syntrophin-1	0.0029	0.0175	0.0606
Onchocerca volvulus		0.0029	0.0175	0.0944
Echinococcus granulosus	regulator of G protein signaling 7	0.016	0.1164	0.1164
Echinococcus granulosus	GRB2 associated binding protein 3	0.0029	0.0175	0.0175
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0029	0.0175	0.0903
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0082	0.0082
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0204	0.5754
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0029	0.0175	0.0175
Echinococcus granulosus	oxysterol binding protein 1	0.0029	0.0175	0.0175
Entamoeba histolytica	hypothetical protein	0.0033	0.0204	0.0294
Toxoplasma gondii	ABC1 family protein	0.0036	0.0225	0.2247
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	PH domain-containing protein	0.0029	0.0175	0.0175
Schistosoma mansoni	regulator of G protein signaling	0.016	0.1164	0.1164
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0399	1
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0029	0.0175	0.0175
Schistosoma mansoni	serine/threonine protein kinase	0.0387	0.2887	0.2887
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0036	0.0036
Loa Loa (eye worm)	cytohesin 3	0.0029	0.0175	0.0175
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0225	0.1176
Schistosoma mansoni	regulator of G protein signaling	0.016	0.1164	0.1164
Echinococcus granulosus	Regulator of G protein signaling 20	0.016	0.1164	0.1164
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0029	0.0175	0.0175
Trichomonas vaginalis	protein transport protein sec7, putative	0.0029	0.0175	0.0903
Echinococcus granulosus	Pleckstrin y	0.0029	0.0175	0.0175
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.1108	0.1108
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0029	0.0175	0.0175
Trypanosoma brucei	protein kinase, putative	0.0033	0.0204	0.5754
Echinococcus multilocularis	regulator of G protein signaling 7	0.016	0.1164	0.1164
Trichomonas vaginalis	hypothetical protein	0.0029	0.0175	0.0903
Loa Loa (eye worm)	syntrophin-1	0.0029	0.0175	0.0175
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0029	0.0175	0.0175
Entamoeba histolytica	hypothetical protein	0.0033	0.0204	0.0294
Mycobacterium ulcerans	lipase LipD	0.0036	0.0225	0.5
Schistosoma mansoni	goodpasture antigen-binding protein	0.0029	0.0175	0.0175
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0029	0.0175	0.00000010082
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trypanosoma cruzi	NIMA-related kinase, putative	0.0033	0.0204	0.5754
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0082	0.0082
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus multilocularis	beta 1 syntrophin	0.0029	0.0175	0.0175
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0225	0.0225
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.1851	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0029	0.0175	0.0175
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0225	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0228	0.0228
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.02	0.111
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0225	0.1176
Loa Loa (eye worm)	RGS-3 protein	0.016	0.1164	0.1164
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Echinococcus granulosus	GPCR family 2	0.0017	0.0082	0.0082
Schistosoma mansoni	zinc finger protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Leishmania major	protein kinase, putative	0.0033	0.0204	0.5754
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0228	0.1679	0.1679
Schistosoma mansoni	myotubularin-related protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	esterase, putative	0.0036	0.0225	0.1176
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0033	0.0204	0.5754
Echinococcus granulosus	expressed protein	0.016	0.1164	0.1164
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1108	0.1108
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0033	0.0204	0.5754
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	regulator of G protein signaling 7	0.016	0.1164	0.1164
Schistosoma mansoni	serine/threonine protein kinase	0.1328	1	1
Echinococcus multilocularis	muscleblind protein	0.0152	0.1108	0.1108
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0033	0.0204	0.5754
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0029	0.0175	0.0944
Schistosoma mansoni	serine/threonine protein kinase	0.1328	1	1
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0029	0.0175	0.0903
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Brugia malayi	CXXC zinc finger family protein	0.003	0.0186	0.0643
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0033	0.0204	0.106
Schistosoma mansoni	oxysterol-binding protein 1	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	hypothetical protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	dynamin 1	0.0029	0.0175	0.0175
Brugia malayi	Dynamin	0.0029	0.0175	0.0606
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0225	0.078
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	rho-GTPase-activating	0.0029	0.0175	0.0175
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0029	0.0175	0.0606
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0225	0.1176
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0022	0.0022
Echinococcus granulosus	oxysterol binding protein 9	0.0029	0.0175	0.0175
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Trypanosoma cruzi	NIMA-related kinase, putative	0.0033	0.0204	0.5754
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.02	0.02
Loa Loa (eye worm)	uncoordinated protein 104	0.0029	0.0175	0.0175
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0225	0.1176
Echinococcus granulosus	axis inhibition protein axin	0.016	0.1164	0.1164
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Brugia malayi	Pleckstrin Homology Domain	0.0029	0.0175	0.0606
Leishmania major	serine/threonine-protein kinase a, putative	0.0033	0.0204	0.5754
Brugia malayi	TBC domain containing protein	0.0029	0.0175	0.0606
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0029	0.0175	0.0175
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0225	0.5
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0225	0.0225
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus granulosus	serine/threonine protein kinase	0.0033	0.0204	0.0204
Schistosoma mansoni	growth factor receptor-bound protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Onchocerca volvulus		0.0251	0.1851	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Brugia malayi	PXA domain containing protein	0.016	0.1164	0.4032
Schistosoma mansoni	hypothetical protein	0.0017	0.0082	0.0082
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0225	0.0225
Echinococcus multilocularis	expressed protein	0.016	0.1164	0.1164
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.02	0.02
Echinococcus granulosus	beta 1 syntrophin	0.0029	0.0175	0.0175
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0186	0.0186
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0298
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0033	0.0204	0.5754
Echinococcus granulosus	DCC interacting protein 13 beta	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Brugia malayi	Oxysterol-binding protein	0.0029	0.0175	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Echinococcus multilocularis	pdz domain containing protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	alpha chimerin, putative	0.0029	0.0175	0.0903
Echinococcus multilocularis	oxysterol binding protein 3	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	PXA domain containing protein	0.016	0.1164	0.4032
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus granulosus	Oxysterol binding protein 11	0.0029	0.0175	0.0175
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0033	0.0204	0.5754
Brugia malayi	Plekhf2 protein	0.0029	0.0175	0.0606
Brugia malayi	probable spectrin beta chain	0.0029	0.0175	0.0606
Echinococcus multilocularis	regulator of G protein signaling	0.016	0.1164	0.1164
Onchocerca volvulus		0.0029	0.0175	0.0944
Schistosoma mansoni	vav2	0.0029	0.0175	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.016	0.1164	0.1164
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0354	0.0354
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0033	0.0204	0.5754
Brugia malayi	hypothetical protein	0.016	0.1164	0.4032
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0225	1
Echinococcus multilocularis	axis inhibition protein axin	0.016	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Schistosoma mansoni	serine/threonine-protein kinase	0.0033	0.0204	0.0204
Echinococcus multilocularis	regulator of G protein signaling 3	0.016	0.1164	0.1164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0298
Echinococcus granulosus	regulator of G protein signaling 3	0.016	0.1164	0.1164
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.016	0.1164	0.6271
Schistosoma mansoni	cpg binding protein	0.003	0.0186	0.0186
Echinococcus multilocularis	axis inhibition protein axin	0.016	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Echinococcus granulosus	oxysterol binding protein 3	0.0029	0.0175	0.0175
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.02	0.02
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0225	0.5
Brugia malayi	Uncoordinated protein 104	0.0029	0.0175	0.0606
Echinococcus granulosus	calcium dependent secretion activator 1	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trichomonas vaginalis	centaurin alpha, putative	0.0029	0.0175	0.0903
Schistosoma mansoni	cpg binding protein	0.0032	0.0199	0.0199
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0033	0.0204	0.5754
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0228	0.1679	0.1679
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.1164	0.6271
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0029	0.0175	0.0903
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0022	0.0022
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0035	0.0122
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0029	0.0175	0.0175
Brugia malayi	Regulator of G protein signaling domain containing protein	0.016	0.1164	0.4032
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Onchocerca volvulus		0.0036	0.0225	0.1217
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	oxysterol binding protein 1	0.0029	0.0175	0.0175
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1168	0.8793	0.8793
Schistosoma mansoni	dynamin	0.0029	0.0175	0.0175
Loa Loa (eye worm)	PXA domain-containing protein	0.016	0.1164	0.1164
Entamoeba histolytica	p21-activated kinase	0.0033	0.0204	0.0294
Schistosoma mansoni	hypothetical protein	0.0029	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0017	0.0082	0.0082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0298	0.0298
Trichomonas vaginalis	centaurin/arf, putative	0.0029	0.0175	0.0903
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0033	0.0204	0.5754
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.016	0.1164	0.1164
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.02	0.02
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus multilocularis	dnaJ subfamily B	0.0431	0.3219	0.3219
Schistosoma mansoni	zinc finger protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0225	0.0225
Onchocerca volvulus		0.0029	0.0175	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0032	0.02	0.02
Brugia malayi	Pre-SET motif family protein	0.022	0.1622	0.5618
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.016	0.1164	0.1164
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0029	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Onchocerca volvulus		0.0032	0.02	0.1079
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.016	0.1164	0.1164
Schistosoma mansoni	oxysterol-binding protein 1	0.0029	0.0175	0.0175
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0029	0.0175	0.0175
Plasmodium vivax	SET domain protein, putative	0.0032	0.02	0.4938
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0387	0.2887	0.2887
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0298
Brugia malayi	Variant SH3 domain containing protein	0.0029	0.0175	0.0606
Schistosoma mansoni	hypothetical protein	0.0431	0.3219	0.3219
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Echinococcus multilocularis	cytohesin 1	0.0029	0.0175	0.0175
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0029	0.0175	0.0175
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Echinococcus multilocularis	Pleckstrin y	0.0029	0.0175	0.0175
Echinococcus granulosus	regulator of G protein signaling 3	0.016	0.1164	0.1164
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0225	0.5
Echinococcus granulosus	dynamin 1	0.0029	0.0175	0.0175
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0228	0.1679	0.5817
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0204	0.0706
Leishmania major	hypothetical protein, conserved	0.0036	0.0225	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0029	0.0175	0.0175
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0082	0.0082
Entamoeba histolytica	hypothetical protein	0.016	0.1164	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0199	0.0199
Schistosoma mansoni	dynamin	0.0029	0.0175	0.0175
Brugia malayi	Oxysterol binding protein	0.0029	0.0175	0.0606
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Schistosoma mansoni	z-protein (S1r protein)	0.016	0.1164	0.1164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1108	0.1108
Schistosoma mansoni	hypothetical protein	0.0036	0.0228	0.0228
Schistosoma mansoni	serine/threonine-protein kinase	0.0033	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.016	0.1164	0.1164
Echinococcus multilocularis	Pleckstrin y	0.0029	0.0175	0.0175
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.016	0.1164	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0175
Brugia malayi	PH domain containing protein	0.0029	0.0175	0.0606
Echinococcus granulosus	dnaJ subfamily B	0.0431	0.3219	0.3219
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0082	0.0082
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0354	0.1227
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0387	0.2887	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0204	0.0294
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0029	0.0175	0.0175
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0033	0.0204	0.5754
Echinococcus granulosus	muscleblind protein	0.0152	0.1108	0.1108
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.1622	0.1622
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0029	0.0175	0.0175
Echinococcus granulosus	axis inhibition protein axin	0.016	0.1164	0.1164
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0204	0.106
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0225
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0029	0.0175	0.0944
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0175	0.0903
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0228	0.0791
Onchocerca volvulus	outspread protein homolog	0.0029	0.0175	0.0944
Schistosoma mansoni	hypothetical protein	0.0017	0.0082	0.0082
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0033	0.0204	0.5754
Echinococcus multilocularis	regulator of G protein signaling 3	0.016	0.1164	0.1164
Echinococcus granulosus	cytohesin 1	0.0029	0.0175	0.0175
Echinococcus granulosus	myotubularin protein 13	0.0029	0.0175	0.0175
Onchocerca volvulus		0.0029	0.0175	0.0944
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0225	0.1176
Entamoeba histolytica	protein kinase, putative	0.0033	0.0204	0.0294
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.02	0.02
Brugia malayi	A-kinase anchor protein 10, precursor	0.016	0.1164	0.4032
Echinococcus multilocularis	cpg binding protein	0.0032	0.0199	0.0199
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.02	0.02
Onchocerca volvulus	Putative zinc finger protein	0.0029	0.0175	0.0944

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= -11.1 %	Induction of human CB1 receptor internalization expressed in HEK293 cells at 10 uM relative to CP55940	ChEMBL.	24125850
Activity (binding)	= 79.6 %	Induction of human CB2 receptor internalization expressed in HEK293 cells at 10 uM relative to CP55940	ChEMBL.	24125850
Ki (binding)	= 122 nM	Displacement of [3H]-CP55940 from CB1 receptor in rat brain homogenate after 1.5 hrs by microbeta liquid scintillation counting analysis	ChEMBL.	24125850
Ki (binding)	= 370 nM	Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK293 cells after 1.5 hrs by microbeta liquid scintillation counting analysis	ChEMBL.	24125850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441446

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791546