Detailed information for compound 1802968

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.86 | Formula: C23H19ClF2N2O
  • H donors: 1 H acceptors: 1 LogP: 5.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)C(Nc1ccc(cc1)F)CC(N2C(=O)c1ccc(cc1)Cl)C
  • InChi: 1S/C23H19ClF2N2O/c1-14-12-21(27-19-9-6-17(25)7-10-19)20-13-18(26)8-11-22(20)28(14)23(29)15-2-4-16(24)5-3-15/h2-11,13-14,21,27H,12H2,1H3
  • InChiKey: WTBVRUDVERRJSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Aedes aegypti Ecdysone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus DnaJ subfamily C member 16 homolog Ecdysone receptor   484 aa 398 aa 26.1 %
Onchocerca volvulus Ecdysone receptor   484 aa 396 aa 23.5 %
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 Ecdysone receptor   484 aa 406 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0133 0.1326 0.4481
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0413 0.1366
Trichomonas vaginalis tubulin epsilon chain, putative 0.0224 0.2338 0.7895
Plasmodium falciparum tubulin delta chain, putative 0.0068 0.0605 0.2019
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0605 0.2019
Onchocerca volvulus 0.0049 0.0396 0.1684
Brugia malayi Tubulin gamma chain 0.0157 0.159 0.5361
Echinococcus granulosus tubulin alpha 1C chain 0.0224 0.2338 0.2857
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0229 0.0742
Trichomonas vaginalis tubulin epsilon chain, putative 0.0224 0.2338 0.7895
Schistosoma mansoni lamin 0.0029 0.0174 0.0201
Loa Loa (eye worm) BEN-1 protein 0.028 0.2958 1
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0037 0.0116
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0163 0.0157
Schistosoma mansoni alpha tubulin 0.0224 0.2338 0.2854
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0247 0.1032
Echinococcus granulosus tar DNA binding protein 0.0069 0.0613 0.0743
Trichomonas vaginalis tubulin alpha chain, putative 0.028 0.2958 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0276 0.0932
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0259 0.0843
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0163 0.0519
Schistosoma mansoni hypothetical protein 0.0041 0.0299 0.0355
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0283 0.0335
Loa Loa (eye worm) hypothetical protein 0.0221 0.2304 0.779
Giardia lamblia Beta tubulin 0.028 0.2958 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0247 0.0241
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0259 0.0843
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0247 0.029
Leishmania major beta tubulin 0.028 0.2958 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0247 0.0803
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0059 0.0167
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0229 0.0742
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0037 0.0033
Echinococcus multilocularis chromobox protein 1 0.0078 0.0721 0.0716
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0163 0.0519
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0037 0.0091
Brugia malayi beta-tubulin, identical 0.028 0.2958 1
Brugia malayi hypothetical protein 0.0041 0.0299 0.0982
Schistosoma mansoni tubulin subunit alpha 0.0068 0.0605 0.073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0247 0.029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0247 0.1032
Echinococcus multilocularis tubulin delta chain 0.0068 0.0605 0.06
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.0041
Echinococcus granulosus tubulin gamma 1 chain 0.0157 0.159 0.1942
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0247 0.0803
Trichomonas vaginalis tubulin, putative 0.0089 0.0834 0.2796
Loa Loa (eye worm) hypothetical protein 0.0034 0.0232 0.0786
Brugia malayi Heterochromatin protein 1 0.0078 0.0721 0.2413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.02
Trichomonas vaginalis tubulin, putative 0.0068 0.0605 0.2019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0259 0.0874
Brugia malayi steroid hormone receptor 0.0036 0.0247 0.0803
Echinococcus multilocularis lamin dm0 0.0029 0.0174 0.0168
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0247 0.029
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0247 0.0295
Echinococcus granulosus muscleblind protein 0.0168 0.1719 0.2099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0247 0.0803
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.6504
Loa Loa (eye worm) tubulin beta-1 chain 0.028 0.2958 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0174 0.0589
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0156 0.1581 0.533
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.043 0.1426
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0247 0.0241
Schistosoma mansoni nuclear receptor 0.0017 0.0037 0.0033
Schistosoma mansoni hypothetical protein 0.0038 0.0276 0.0326
Mycobacterium leprae Probable lipase LipE 0.0039 0.0283 0.4587
Trypanosoma brucei zeta tubulin, putative 0.0068 0.0605 0.2019
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Echinococcus multilocularis beta tubulin 0.028 0.2958 0.2954
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0247 0.0295
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2958 1
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2338 0.2333
Onchocerca volvulus 0.0049 0.0397 0.1687
Loa Loa (eye worm) alpha-tubulin 0.0224 0.2338 0.7902
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0283 0.0335
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0413 0.1366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0247 0.0834
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2958 0.2954
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.1045
Echinococcus multilocularis tubulin alpha 1C chain 0.0224 0.2338 0.2333
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0156 0.1581 0.5346
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0283 0.0957
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0037 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0195 0.0628
Leishmania major beta tubulin 0.028 0.2958 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 0.0926
Echinococcus multilocularis muscleblind protein 0.0168 0.1719 0.1714
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0397 0.1482
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Echinococcus granulosus tumor protein p63 0.0336 0.3587 0.4389
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.6504
Leishmania major beta tubulin 0.028 0.2958 1
Onchocerca volvulus 0.0039 0.0283 0.119
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0596 0.2015
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2338 0.2333
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0224 0.2338 0.7895
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0283 0.4587
Echinococcus multilocularis microtubule associated protein 2 0.0748 0.8166 0.8165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0195 0.201 0.2457
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0259 0.0952
Leishmania major beta tubulin 0.028 0.2958 1
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0163 0.0519
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0375 0.1238
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0037 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1313
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0247 0.0295
Mycobacterium ulcerans cell division protein FtsZ 0.0068 0.0605 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0037 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0247 0.029
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0283 0.4587
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0247 0.0803
Echinococcus granulosus tubulin epsilon chain 0.0157 0.159 0.1942
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0397 0.6504
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0276 0.0901
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.1313
Brugia malayi nuclear receptor NHR-88 0.0017 0.0037 0.0091
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0605 0.2019
Loa Loa (eye worm) hypothetical protein 0.0156 0.1581 0.5346
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0236 0.0866
Plasmodium vivax tubulin alpha chain, putative 0.0224 0.2338 0.7895
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0413 0.1366
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0299 0.036
Brugia malayi intermediate filament protein 0.0029 0.0174 0.0557
Brugia malayi Tubulin alpha chain 0.0224 0.2338 0.7895
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0613 0.0739
Echinococcus granulosus tubulin subunit TubB 0.0224 0.2338 0.2857
Brugia malayi Tubulin beta-1 chain 0.028 0.2958 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0283 0.1045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0283 0.1045
Echinococcus multilocularis tubulin subunit beta 0.028 0.2958 0.2954
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0283 0.0926
Entamoeba histolytica hypothetical protein 0.0041 0.0299 0.0982
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0045
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0229 0.0742
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2958 0.3618
Leishmania major beta tubulin 0.028 0.2958 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.04 0.0479
Brugia malayi Tubulin alpha-2 chain 0.0224 0.2338 0.7895
Onchocerca volvulus 0.0089 0.0834 0.3593
Trichomonas vaginalis tubulin, putative 0.028 0.2958 1
Trypanosoma brucei tubulin gamma chain 0.0157 0.159 0.5361
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0163 0.0519
Onchocerca volvulus Huntingtin homolog 0.0133 0.1326 0.5734
Plasmodium vivax tubulin gamma chain, putative 0.0157 0.159 0.5361
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0045
Mycobacterium tuberculosis Cell division protein FtsZ 0.0068 0.0605 0.2279
Brugia malayi beta-lactamase 0.0039 0.0283 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0247 0.0803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0037 0.0038
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0413 0.0894
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0283 0.1045
Loa Loa (eye worm) tubulin alpha-3 chain 0.0135 0.1352 0.4571
Plasmodium falciparum tubulin epsilon chain, putative 0.0157 0.159 0.5361
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.6504
Loa Loa (eye worm) hypothetical protein 0.0037 0.0259 0.0874
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0037 0.0124
Echinococcus multilocularis lamin 0.0029 0.0174 0.0168
Loa Loa (eye worm) beta-tubulin 0.028 0.2958 1
Brugia malayi conserved hypotetical protein 0.0017 0.0037 0.0091
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0229 0.0742
Echinococcus multilocularis tubulin alpha 1C chain 0.0224 0.2338 0.2333
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2958 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0068 0.0605 0.2019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2338 0.2854
Trichomonas vaginalis tubulin, putative 0.0089 0.0834 0.2796
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0089 0.0834 0.2796
Brugia malayi nuclear hormone receptor 0.0036 0.0247 0.0803
Brugia malayi nuclear receptor NHR-67 0.0017 0.0037 0.0091
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.1581 0.5346
Brugia malayi Tubulin alpha chain 0.0068 0.0605 0.2019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0247 0.0295
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0037 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.04 0.0395
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0229 0.0223
Echinococcus multilocularis tubulin beta 1 chain 0.028 0.2958 0.2954
Onchocerca volvulus 0.0039 0.0283 0.119
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0338 0.1429
Giardia lamblia Delta tubulin 0.0068 0.0605 0.1582
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0834 0.2796
Brugia malayi tubulin alpha-2 chain 0.0224 0.2338 0.7895
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0163 0.0551
Leishmania major beta tubulin 0.028 0.2958 1
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0247 0.029
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0229 0.0742
Trypanosoma brucei alpha tubulin, putative 0.0089 0.0834 0.2796
Toxoplasma gondii beta tubulin 0.028 0.2958 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0613 0.0607
Echinococcus granulosus tubulin beta 1 chain 0.028 0.2958 0.3618
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0413 0.0407
Loa Loa (eye worm) tubulin alpha chain 0.0224 0.2338 0.7902
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.04 0.0395
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.159 0.5361
Echinococcus granulosus tubulin alpha chain 0.0224 0.2338 0.2857
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2338 0.2857
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0034
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0397 0.6504
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0375 0.1591
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Echinococcus multilocularis tubulin gamma 1 chain 0.0157 0.159 0.1585
Entamoeba histolytica hypothetical protein 0.0041 0.0299 0.0982
Brugia malayi nuclear receptor RXR 0.0017 0.0037 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0247 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2338 0.2333
Echinococcus granulosus tubulin subunit beta 0.028 0.2958 0.3618
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1313
Brugia malayi hypothetical protein 0.0256 0.2699 0.9121
Echinococcus multilocularis tubulin alpha 3 chain 0.0224 0.2338 0.2333
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2958 0.2954
Onchocerca volvulus 0.0039 0.0283 0.119
Leishmania major zeta tubulin, putative 0.0068 0.0605 0.2019
Schistosoma mansoni zinc finger protein 0.0017 0.0037 0.0033
Brugia malayi nuclear hormone receptor 0.0017 0.0037 0.0091
Loa Loa (eye worm) tubulin gamma chain 0.0157 0.159 0.5377
Echinococcus multilocularis tumor protein p63 0.0336 0.3587 0.3584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.04 0.0483
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0283 0.0926
Loa Loa (eye worm) hypothetical protein 0.0133 0.1326 0.4481
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0247 0.0803
Onchocerca volvulus 0.0036 0.0247 0.1032
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Echinococcus granulosus tubulin alpha chain 0.0224 0.2338 0.2857
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0037 0.0038
Giardia lamblia Alpha-tubulin 0.0224 0.2338 0.778
Loa Loa (eye worm) tubulin alpha chain 0.0224 0.2338 0.7902
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0247 0.0241
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0413 0.0499
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0229 0.0773
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0247 0.029
Brugia malayi beta-lactamase family protein 0.0039 0.0283 0.0926
Onchocerca volvulus 0.0017 0.0037 0.0116
Trypanosoma brucei alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0047 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1313
Leishmania major hypothetical protein, conserved 0.0034 0.0229 0.0742
Onchocerca volvulus 0.0017 0.0037 0.0116
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0037 0.0091
Entamoeba histolytica hypothetical protein 0.0041 0.0299 0.0982
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0397 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0338 0.1113
Giardia lamblia Gamma tubulin 0.0157 0.159 0.5107
Echinococcus granulosus intermediate filament protein 0.0029 0.0174 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0473 0.1571
Loa Loa (eye worm) hypothetical protein 0.0049 0.0396 0.134
Onchocerca volvulus Bile acid receptor homolog 0.0221 0.2304 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0224 0.2338 0.2333
Brugia malayi hypothetical protein 0.0133 0.1326 0.4463
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.1045
Toxoplasma gondii ABC1 family protein 0.0039 0.0283 0.0926
Mycobacterium ulcerans lipase LipD 0.0039 0.0283 0.4587
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0283 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0375 0.1238
Brugia malayi Tubulin alpha-2 chain 0.0224 0.2338 0.7895
Loa Loa (eye worm) tubulin alpha-2 chain 0.0224 0.2338 0.7902
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2958 0.3618
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0037 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 0.0926
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2958 0.3618
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Echinococcus granulosus GPCR family 2 0.0018 0.0047 0.005
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0174 0.0589
Plasmodium falciparum flap endonuclease 1 0.0028 0.0163 0.0519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.04 0.0479
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0589
Trypanosoma brucei beta tubulin 0.028 0.2958 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0224 0.2338 0.2333
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2338 0.2333
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0613 0.2071
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0247 0.0241
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0174 0.0557
Trichomonas vaginalis tubulin gamma chain, putative 0.028 0.2958 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0473 0.1599
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0283 0.034
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2338 0.2333
Entamoeba histolytica tubulin gamma chain 0.0157 0.159 0.5361
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.1581 0.5346
Trypanosoma brucei tubulin delta chain 0.0068 0.0605 0.2019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0047 0.0124
Brugia malayi Flap endonuclease-1 0.0028 0.0163 0.0519
Brugia malayi Cell division protein ftsZ 0.0068 0.0605 0.2019
Loa Loa (eye worm) hypothetical protein 0.0168 0.1719 0.5811
Onchocerca volvulus 0.0034 0.0232 0.0969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0247 0.0241
Trichomonas vaginalis esterase, putative 0.0039 0.0283 0.0926
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.2621 1
Toxoplasma gondii alpha-tubulin I, putative 0.0224 0.2338 0.7895
Leishmania major beta tubulin 0.028 0.2958 1
Echinococcus multilocularis hypothetical protein 0.0224 0.2338 0.2333
Giardia lamblia Beta tubulin 0.028 0.2958 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0259 0.0874
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0229 0.0742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.04 0.0483
Echinococcus granulosus beta tubulin 0.028 0.2958 0.3618
Brugia malayi chromobox protein homolog 3 0.0044 0.0338 0.1113
Onchocerca volvulus 0.0029 0.0174 0.0715
Trypanosoma brucei alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0247 0.0834
Loa Loa (eye worm) tubulin beta-2A chain 0.028 0.2958 1
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0247 0.0803
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0299 0.0294
Echinococcus granulosus flap endonuclease 1 0.0028 0.0163 0.0192
Echinococcus granulosus alpha tubulin 0.0224 0.2338 0.2857
Entamoeba histolytica tubulin alpha chain, putative 0.0224 0.2338 0.7895
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.02
Schistosoma mansoni chromobox protein 0.0078 0.0721 0.0872
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Brugia malayi Muscleblind-like protein 0.0168 0.1719 0.5797
Loa Loa (eye worm) hypothetical protein 0.0135 0.1352 0.4571
Echinococcus granulosus tubulin beta 4A class IVa 0.028 0.2958 0.3618
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.04 0.1353
Schistosoma mansoni coup transcription factor 0.0036 0.0247 0.029
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0834 0.2796
Brugia malayi ecdysteroid receptor 0.0221 0.2304 0.7783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0247 0.0803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0283 0.1045
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0195 0.0628
Toxoplasma gondii beta-1 tubulin, putative 0.028 0.2958 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0613 0.0739
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0413 0.1366
Brugia malayi Tubulin beta chain 0.0068 0.0605 0.2019
Loa Loa (eye worm) RNA binding protein 0.0069 0.0613 0.2071
Echinococcus granulosus lamin dm0 0.0029 0.0174 0.0206
Loa Loa (eye worm) DR-78 0.0017 0.0037 0.0124
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2338 0.2854
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.02
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Brugia malayi ecdysone receptor 0.0017 0.0037 0.0091
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0247 0.0803
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.0834 0.2796
Toxoplasma gondii beta-tubulin, putative 0.028 0.2958 1
Schistosoma mansoni retinoic acid receptor RXR 0.0195 0.201 0.2453
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0068 0.0605 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0283 0.0277
Schistosoma mansoni hypothetical protein 0.0052 0.043 0.0515
Entamoeba histolytica hypothetical protein 0.0041 0.0299 0.0982
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0037 0.0091
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.1045
Loa Loa (eye worm) hypothetical protein 0.0168 0.1719 0.5811
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0247 0.0241
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0247 0.029
Schistosoma mansoni intermediate filament proteins 0.0029 0.0174 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Echinococcus granulosus tubulin alpha chain 0.0224 0.2338 0.2857
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0037 0.0038
Schistosoma mansoni tubulin subunit epsilon 0.0157 0.159 0.1938
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Brugia malayi alpha-tubulin 0.0224 0.2338 0.7895
Trypanosoma cruzi beta tubulin, putative 0.028 0.2958 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0247 0.0834
Leishmania major delta tubulin, putative 0.0068 0.0605 0.2019
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0605 0.2019
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0299 0.0355
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.2699 0.33
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0247 0.0834
Brugia malayi Augmenter of liver regeneration 0.0034 0.0229 0.0742
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.001 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0247 0.0295
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Schistosoma mansoni microtubule-associated protein tau 0.0748 0.8166 1
Echinococcus granulosus tubulin alpha 3 chain 0.0224 0.2338 0.2857
Schistosoma mansoni tubulin subunit gamma 0.0157 0.159 0.1938
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0259 0.4177
Giardia lamblia Beta tubulin 0.028 0.2958 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0247 0.0295
Trypanosoma brucei epsilon tubulin 0.0157 0.159 0.5361
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0247 0.0803
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0229 0.0273
Echinococcus multilocularis tubulin alpha 0.0157 0.159 0.1585
Loa Loa (eye worm) hypothetical protein 0.0044 0.0338 0.1143
Entamoeba histolytica tubulin family protein 0.028 0.2958 1
Trypanosoma brucei epsilon tubulin 0.0157 0.159 0.5361
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0037 0.0031
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2958 0.2954
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0605 0.2019
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Plasmodium vivax tubulin epsilon chain, putative 0.0157 0.159 0.5361
Leishmania major gamma-tubulin 0.0157 0.159 0.5361
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0037 0.0033
Echinococcus granulosus tubulin alpha 3 chain 0.0224 0.2338 0.2857
Leishmania major beta tubulin 0.028 0.2958 1
Leishmania major beta tubulin 0.028 0.2958 1
Trichomonas vaginalis tubulin beta chain, putative 0.0089 0.0834 0.2796
Trypanosoma cruzi tubulin delta chain 0.0068 0.0605 0.2019
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0229 0.0742
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0413 0.1366
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0247 0.029
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0059 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0413 0.1366
Leishmania major beta tubulin 0.028 0.2958 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0037 0.0031
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0397 0.1313
Schistosoma mansoni flap endonuclease-1 0.0026 0.0133 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1343
Trichomonas vaginalis tubulin epsilon chain, putative 0.0068 0.0605 0.2019
Trypanosoma brucei protein kinase, putative 0.0051 0.0413 0.1366
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0413 0.1366
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 0.0926
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0176 0.18 0.1796
Onchocerca volvulus 0.0052 0.043 0.1832
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0247 0.0834
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.159 0.5361
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.001 0.0034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.04 0.1324
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0037 0.0031
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.005
Plasmodium vivax tubulin beta chain, putative 0.028 0.2958 1
Echinococcus granulosus tubulin alpha 0.0157 0.159 0.1942
Plasmodium vivax delta tubulin, putative 0.0068 0.0605 0.2019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Brugia malayi nuclear receptor RXR 0.0019 0.0059 0.0167
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0259 0.5
Mycobacterium ulcerans beta-lactamase 0.0039 0.0283 0.4587
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0135 0.1352 0.4553
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Schistosoma mansoni tubulin subunit delta 0.0068 0.0605 0.073
Schistosoma mansoni alpha tubulin 0.0224 0.2338 0.2854
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0247 0.029
Echinococcus granulosus beta tubulin 0.028 0.2958 0.3618
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0613 0.2044
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1313
Brugia malayi hypothetical protein 0.0019 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0236 0.0866
Brugia malayi TAR-binding protein 0.0069 0.0613 0.2044
Trypanosoma brucei zeta tubulin 0.0068 0.0605 0.2019
Echinococcus granulosus peroxisome assembly protein 26 0.0224 0.2338 0.2857
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.6504
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1719 0.1714
Plasmodium vivax tubulin alpha chain, putative 0.0224 0.2338 0.7895
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0247 0.0803
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0413 0.0499
Echinococcus granulosus chromobox protein 1 0.0078 0.0721 0.0877
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1313
Toxoplasma gondii alpha tubulin TUBA1 0.0224 0.2338 0.7895
Echinococcus multilocularis tubulin epsilon chain 0.0157 0.159 0.1585
Trypanosoma cruzi tubulin gamma chain 0.0157 0.159 0.5361
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2338 0.2857
Brugia malayi nuclear receptor NHR-88 0.0036 0.0247 0.0803
Echinococcus granulosus chromobox protein 1 0.0078 0.0721 0.0877
Trypanosoma cruzi alpha tubulin, putative 0.0224 0.2338 0.7895
Leishmania major beta tubulin 0.028 0.2958 1
Schistosoma mansoni nuclear receptor 0.0017 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.6504
Echinococcus multilocularis musashi 0.0029 0.0174 0.0168
Treponema pallidum cell division protein FtsZ 0.0068 0.0605 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0037 0.0031
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0283 0.1045
Leishmania major beta tubulin 0.028 0.2958 1
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0247 0.0241
Loa Loa (eye worm) hypothetical protein 0.0056 0.0473 0.1599
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2958 0.2954
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.2699 0.2695
Schistosoma mansoni tubulin subunit beta 0.0068 0.0605 0.073
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2338 0.2333
Plasmodium falciparum tubulin gamma chain 0.0157 0.159 0.5361
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.159 0.5361
Trypanosoma brucei epsilon tubulin 0.0157 0.159 0.5361
Leishmania major beta tubulin 0.028 0.2958 1
Schistosoma mansoni alpha tubulin 0.0224 0.2338 0.2854
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0396 0.0474
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0047 0.0124
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0397 0.6504
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0247 0.0295
Schistosoma mansoni chromobox protein 0.0078 0.0721 0.0872
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0834
Brugia malayi hypothetical protein 0.0017 0.0037 0.0091
Brugia malayi tubulin alpha chain - mouse 0.0224 0.2338 0.7895
Giardia lamblia Alpha-tubulin 0.0224 0.2338 0.778
Brugia malayi tailless protein 0.0017 0.0037 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0413 0.1366
Brugia malayi Tubulin beta chain 0.0089 0.0834 0.2796
Echinococcus multilocularis tubulin, beta 4A class IVa 0.028 0.2958 0.2954
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.1313
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Schistosoma mansoni tubulin subunit alpha 0.0224 0.2338 0.2854
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0283 0.1045
Leishmania major beta tubulin 0.028 0.2958 1
Onchocerca volvulus Huntingtin homolog 0.0133 0.1326 0.5734
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0613 0.2071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1343
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0037 0.0124
Trypanosoma cruzi tubulin delta chain 0.0068 0.0605 0.2019
Trypanosoma brucei beta tubulin 0.0157 0.159 0.5361
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0157 0.159 0.5361
Schistosoma mansoni lamin 0.0029 0.0174 0.0201
Echinococcus multilocularis Tubulin beta 2C chain 0.028 0.2958 0.2954
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.159 0.5361
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Echinococcus granulosus microtubule associated protein 2 0.0748 0.8166 1
Leishmania major hypothetical protein, conserved 0.0039 0.0283 0.0926
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0037 0.0038
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0229 0.0742
Plasmodium falciparum alpha tubulin 1 0.0224 0.2338 0.7895
Loa Loa (eye worm) tubulin beta chain 0.0068 0.0605 0.2046
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0283 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0247 0.0803
Onchocerca volvulus 0.0029 0.0174 0.0715
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0163 0.0519
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0247 0.0241
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0283 0.0926
Mycobacterium ulcerans hypothetical protein 0.0039 0.0283 0.4587
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Loa Loa (eye worm) alpha-tubulin 0.0224 0.2338 0.7902
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0413 0.1366
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0247 0.029
Trichomonas vaginalis tubulin beta chain, putative 0.0224 0.2338 0.7895
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0413 0.1396
Loa Loa (eye worm) tubulin beta-4 chain 0.028 0.2958 1
Loa Loa (eye worm) BEN-1 protein 0.028 0.2958 1
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0163 0.0519
Loa Loa (eye worm) hypothetical protein 0.0037 0.0259 0.0874
Mycobacterium leprae cell division protein FtsZ 0.0068 0.0605 1
Loa Loa (eye worm) tubulin beta chain 0.028 0.2958 1
Leishmania major beta tubulin 0.028 0.2958 1
Trypanosoma brucei alpha tubulin 0.0224 0.2338 0.7895
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0721 0.2413
Loa Loa (eye worm) hypothetical protein 0.0037 0.0259 0.0874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0247 0.0834
Echinococcus multilocularis Tubulin alpha 1 chain 0.0224 0.2338 0.2333
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Echinococcus multilocularis tubulin alpha chain 0.0224 0.2338 0.2333
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0613 0.0739
Echinococcus multilocularis beta tubulin 0.028 0.2958 0.2954
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0283 0.4587
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0413 0.1366
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0957
Leishmania major epsilon tubulin, putative 0.0157 0.159 0.5361
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2958 0.3618
Schistosoma mansoni survival motor neuron protein 0.0052 0.043 0.0515
Echinococcus granulosus tubulin delta chain 0.0068 0.0605 0.0734
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0247 0.029
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0283 0.1045
Trypanosoma brucei alpha tubulin 0.0224 0.2338 0.7895
Trypanosoma brucei beta tubulin 0.028 0.2958 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0338 0.1113
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0413 0.0494
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0163 0.0519
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0247 0.0803
Brugia malayi MAP kinase sur-1 0.0051 0.0413 0.1366
Echinococcus multilocularis chromobox protein 1 0.0078 0.0721 0.0716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2958 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0157 0.159 0.5361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0059 0.006
Leishmania major beta tubulin 0.028 0.2958 1
Brugia malayi hypothetical protein 0.0017 0.0037 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0613 0.0739
Brugia malayi hypothetical protein 0.0019 0.0059 0.0167
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0078
Echinococcus multilocularis tubulin subunit TubB 0.0224 0.2338 0.2333
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.02
Echinococcus multilocularis GPCR, family 2 0.0018 0.0047 0.0041
Plasmodium falciparum tubulin beta chain 0.028 0.2958 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0605 0.2019
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0059 0.0167
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0068 0.0605 0.2019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0236 0.0866
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0283 0.0926
Mycobacterium ulcerans hypothetical protein 0.0049 0.0397 0.6504
Echinococcus granulosus lamin 0.0029 0.0174 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0413 0.1366
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0037 0.0124
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0605 0.2019
Loa Loa (eye worm) beta-lactamase 0.0039 0.0283 0.0957
Entamoeba histolytica tubulin family protein 0.028 0.2958 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0473 0.1571
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.001 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0613 0.0739
Brugia malayi RNA binding protein 0.0069 0.0613 0.2044
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.02
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0247 0.0295
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0721 0.2413
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0413 0.0407
Trypanosoma brucei beta tubulin 0.028 0.2958 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.2699 0.9124
Echinococcus granulosus tubulin alpha 1C chain 0.0224 0.2338 0.2857
Schistosoma mansoni tubulin subunit beta 0.028 0.2958 0.3615
Entamoeba histolytica tubulin alpha-1 chain 0.0224 0.2338 0.7895
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0247 0.0803
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0059 0.006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0247 0.0803
Plasmodium falciparum alpha tubulin 2 0.0224 0.2338 0.7895
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0037 0.0116
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0023 0.0045
Echinococcus granulosus Tubulin alpha 1 chain 0.0224 0.2338 0.2857
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0283 0.0926
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0236 0.0866
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.005
Echinococcus granulosus Tubulin beta 2C chain 0.028 0.2958 0.3618
Leishmania major beta tubulin 0.028 0.2958 1
Trypanosoma brucei beta tubulin 0.028 0.2958 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0247 0.0834
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0247 0.0834
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0413 0.1366
Loa Loa (eye worm) hypothetical protein 0.0029 0.0168 0.0568
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0037 0.0033
Echinococcus granulosus tubulin alpha chain 0.0224 0.2338 0.2857
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.0041
Giardia lamblia Epsilon tubulin 0.0068 0.0605 0.1582
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.04 0.0479
Leishmania major alpha tubulin 0.0224 0.2338 0.7895
Loa Loa (eye worm) oxidoreductase 0.0014 0.001 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0247 0.0803
Brugia malayi beta-lactamase family protein 0.0039 0.0283 0.0926
Echinococcus granulosus tubulin alpha chain 0.0224 0.2338 0.2857
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0721 0.2438
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0397 0.6504
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0059 0.0065
Leishmania major beta tubulin 0.028 0.2958 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0059 0.02
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0224 0.2338 0.7902

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 4 Agonist activity at ecdysone receptor in Drosophila melanogaster S2 cells after 24 hr by luciferase reporter gene assay ChEMBL. 20672340
EC50 (binding) = 4.26 Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay ChEMBL. 20672340
EC50 (binding) = 6.19 Agonist activity at Aedes aegypti ecdysone receptor expressed in mammalian cells by reporter gene assay ChEMBL. 20672340
EC50 (binding) = 55 uM Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay ChEMBL. 20069627
EC50 (binding) = 60 uM Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay ChEMBL. 20069627
Efficacy (binding) = 12 % Agonist activity at ecdysone receptor in Drosophila melanogaster S2 cells at 100 uM after 24 hr by luciferase reporter gene assay relative to 20-hydroxyecdysone ChEMBL. 20672340
Efficacy (binding) = 59 % Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide ChEMBL. 20069627
Efficacy (binding) = 64 % Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide ChEMBL. 20069627
Efficacy (binding) = 70 % Agonist activity at Aedes aegypti ecdysone receptor expressed in mammalian cells by reporter gene assay relative to control ChEMBL. 20672340
LC50 (ADMET) > 3.3 Cytotoxicity against Spodoptera littoralis Sl2 cells assessed as cell viability after 24 hr by MTT assay ChEMBL. 20069627

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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