Detailed information for compound 18250

Basic information

Technical information
  • TDR Targets ID: 18250
  • Name: 2-(3-aminophenyl)-N-methyl-N-[(1S,2S)-2-pyrro lidin-1-ylcyclohexyl]acetamide
  • MW: 315.453 | Formula: C19H29N3O
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)CC(=O)N([C@H]1CCCC[C@@H]1N1CCCC1)C
  • InChi: 1S/C19H29N3O/c1-21(19(23)14-15-7-6-8-16(20)13-15)17-9-2-3-10-18(17)22-11-4-5-12-22/h6-8,13,17-18H,2-5,9-12,14,20H2,1H3/t17-,18-/m0/s1
  • InChiKey: XQDDYTOBUXRQQL-ROUUACIJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-aminophenyl)-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]acetamide
  • 2-(3-aminophenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]ethanamide
  • 2-(3-aminophenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidinocyclohexyl]acetamide
  • 2-(3-aminophenyl)-N-methyl-N-[(1S,2S)-2-1-pyrrolidinylcyclohexyl]acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tubulin delta chain 0.013 0.1167 0.1144
Schistosoma mansoni smad1 5 8 and 0.0033 0.0112 0.0112
Loa Loa (eye worm) hexokinase 0.0094 0.0775 0.075
Entamoeba histolytica hexokinase 2 0.0094 0.0775 0.1378
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0049
Echinococcus granulosus intermediate filament protein 0.0027 0.004 0.0037
Entamoeba histolytica hypothetical protein 0.0108 0.0933 0.167
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.026 0.2585 0.2565
Echinococcus granulosus flap endonuclease 1 0.0025 0.0027 0.0024
Echinococcus granulosus hexokinase type 2 0.0094 0.0775 0.0772
Trichomonas vaginalis tubulin beta chain, putative 0.0522 0.5455 0.5443
Trypanosoma brucei hexokinase 0.0094 0.0775 0.075
Echinococcus granulosus GPCR family 2 0.0033 0.0109 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Trichomonas vaginalis tubulin, putative 0.013 0.1167 0.1144
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0112 0.0109
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.1597 0.1575
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.026 0.2585 0.2583
Trypanosoma brucei epsilon tubulin 0.0299 0.3015 0.2996
Echinococcus granulosus dna polymerase eta 0.0066 0.0472 0.0469
Echinococcus granulosus Smad4 0.0033 0.0112 0.0109
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0939 1 1
Echinococcus granulosus geminin 0.0699 0.7384 0.7383
Echinococcus multilocularis hexokinase 0.0094 0.0775 0.0772
Trichomonas vaginalis tubulin gamma chain, putative 0.0299 0.3015 0.2996
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Echinococcus multilocularis tubulin alpha 3 chain 0.042 0.434 0.4339
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0175 0.0149
Echinococcus multilocularis Tubulin beta 2C chain 0.0522 0.5455 0.5454
Plasmodium vivax delta tubulin, putative 0.013 0.1167 0.1144
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0939 1 1
Schistosoma mansoni hypothetical protein 0.0699 0.7384 0.7384
Plasmodium vivax tubulin beta chain, putative 0.0522 0.5455 0.5443
Loa Loa (eye worm) tubulin alpha 2 0.0291 0.2922 0.2903
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0743 0.786 0.7854
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0112 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0939 1 1
Trypanosoma cruzi hexokinase, putative 0.0094 0.0775 0.075
Trypanosoma brucei beta tubulin 0.0522 0.5455 0.5443
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0285 0.0108
Plasmodium falciparum tubulin beta chain 0.0522 0.5455 0.5443
Echinococcus multilocularis hexokinase type 2 0.0094 0.0775 0.0772
Trichomonas vaginalis tubulin epsilon chain, putative 0.0522 0.5455 0.5443
Echinococcus multilocularis Tubulin beta 2C chain 0.0522 0.5455 0.5454
Trypanosoma cruzi zeta tubulin, putative 0.013 0.1167 0.1144
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0027 0.0024
Echinococcus multilocularis dna polymerase eta 0.0066 0.0472 0.0469
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0251 0.2492 0.2472
Loa Loa (eye worm) MH2 domain-containing protein 0.0487 0.5065 0.5052
Plasmodium falciparum tubulin delta chain, putative 0.013 0.1167 0.1144
Trichomonas vaginalis tubulin epsilon chain, putative 0.042 0.434 0.4325
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.0109
Trypanosoma brucei beta tubulin 0.0522 0.5455 0.5443
Schistosoma mansoni tubulin subunit alpha 0.042 0.434 0.434
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0285 0.0285
Plasmodium falciparum alpha tubulin 2 0.042 0.434 0.4325
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0939 1 1
Brugia malayi hypothetical protein 0.0108 0.0933 0.0909
Schistosoma mansoni tubulin subunit alpha 0.042 0.434 0.434
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Echinococcus granulosus tubulin alpha chain 0.042 0.434 0.4339
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.026 0.2585 0.4713
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Trypanosoma cruzi solanesyl-diphosphate synthase 0.026 0.2585 0.2565
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0939 1 1
Echinococcus granulosus beta tubulin 0.0522 0.5455 0.5454
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0472 0.0446
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) alpha-tubulin 0.042 0.434 0.4325
Loa Loa (eye worm) tubulin alpha 2 0.0121 0.1075 0.1051
Echinococcus multilocularis tubulin alpha chain 0.042 0.434 0.4339
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Leishmania major polyprenyl synthase, putative 0.0354 0.361 0.3593
Toxoplasma gondii beta-1 tubulin, putative 0.0522 0.5455 0.5443
Leishmania major DNA polymerase eta, putative 0.0066 0.0472 0.0446
Echinococcus granulosus beta tubulin 0.0522 0.5455 0.5454
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Echinococcus granulosus Tubulin alpha 1 chain 0.042 0.434 0.4339
Leishmania major hexokinase, putative 0.0094 0.0775 0.075
Plasmodium falciparum tubulin gamma chain 0.0299 0.3015 0.2996
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0939 1 1
Giardia lamblia DINP protein human, muc B family 0.0039 0.0179 0.0153
Echinococcus granulosus tubulin epsilon chain 0.0299 0.3015 0.3013
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.026 0.2585 0.245
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0354 0.361 0.3593
Trypanosoma brucei unspecified product 0.0027 0.0046 0.0019
Entamoeba histolytica tubulin alpha chain, putative 0.042 0.434 0.7946
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0354 0.361 0.3609
Echinococcus multilocularis geminin 0.0699 0.7384 0.7383
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Trypanosoma cruzi polyprenyl synthase, putative 0.0354 0.361 0.3593
Trichomonas vaginalis tubulin beta-1 chain, putative 0.013 0.1167 0.1144
Echinococcus multilocularis Smad4 0.0033 0.0112 0.0109
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0314 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0314 0.0288
Echinococcus multilocularis Tubulin beta 2C chain 0.0522 0.5455 0.5454
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.004 0.0013
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.026 0.2585 0.245
Plasmodium vivax hexokinase, putative 0.0094 0.0775 0.075
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.026 0.2585 0.2565
Loa Loa (eye worm) tubulin alpha-3 chain 0.0251 0.2492 0.2472
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0179 0.0179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0109 0.0107
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0743 0.786 0.7854
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0109 0.0083
Trypanosoma brucei hexokinase, putative 0.0094 0.0775 0.075
Echinococcus multilocularis tubulin alpha 3 chain 0.042 0.434 0.4339
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Onchocerca volvulus 0.0094 0.0775 0.3194
Loa Loa (eye worm) hexokinase 0.0029 0.0067 0.004
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Echinococcus multilocularis hexokinase 0.0094 0.0775 0.0772
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0285 0.0259
Schistosoma mansoni hypothetical protein 0.0071 0.0526 0.0526
Echinococcus granulosus tubulin alpha 3 chain 0.042 0.434 0.4339
Trypanosoma cruzi tubulin gamma chain 0.0299 0.3015 0.2996
Loa Loa (eye worm) BEN-1 protein 0.0522 0.5455 0.5443
Leishmania major alpha tubulin 0.042 0.434 0.4325
Loa Loa (eye worm) tubulin beta chain 0.013 0.1167 0.1144
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0743 0.786 0.7854
Brugia malayi Pax transcription factor protein 2 0.0237 0.2341 0.232
Brugia malayi intermediate filament protein 0.0027 0.004 0.0013
Schistosoma mansoni tubulin subunit delta 0.013 0.1167 0.1167
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0291 0.2922 0.2903
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0743 0.786 0.7854
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0109 0.0083
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0939 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0109 0.0083
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0743 0.786 0.7854
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0314 0.0288
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.0109
Trypanosoma cruzi epsilon tubulin, putative 0.0299 0.3015 0.2996
Echinococcus multilocularis Tubulin beta 2C chain 0.0522 0.5455 0.5454
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Brugia malayi Tubulin alpha-2 chain 0.042 0.434 0.4325
Echinococcus multilocularis Tubulin alpha 1 chain 0.042 0.434 0.4339
Brugia malayi alpha-tubulin 0.042 0.434 0.4325
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0743 0.786 0.7854
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0169 0.1597 0.1575
Echinococcus granulosus tubulin beta 1 chain 0.0522 0.5455 0.5454
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Leishmania major hypothetical protein, conserved 0.0052 0.0314 0.0288
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0285 0.0259
Echinococcus multilocularis Tubulin alpha 1 chain 0.042 0.434 0.4339
Echinococcus multilocularis hypothetical protein 0.042 0.434 0.4339
Toxoplasma gondii hexokinase 0.0094 0.0775 0.075
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0939 1 1
Echinococcus granulosus tubulin alpha 0.0299 0.3015 0.3013
Onchocerca volvulus Hexokinase homolog 0.0059 0.0393 0.1534
Trichomonas vaginalis tubulin alpha chain, putative 0.0169 0.1597 0.1575
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0939 1 1
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Brugia malayi Hexokinase family protein 0.0029 0.0067 0.004
Echinococcus granulosus lamin dm0 0.0027 0.004 0.0037
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0939 1 1
Loa Loa (eye worm) beta-tubulin 0.0522 0.5455 0.5443
Trypanosoma brucei beta tubulin 0.0522 0.5455 0.5443
Trichomonas vaginalis tubulin, putative 0.0169 0.1597 0.1575
Giardia lamblia Alpha-tubulin 0.042 0.434 0.4325
Loa Loa (eye worm) hypothetical protein 0.0291 0.2922 0.2903
Giardia lamblia Gamma tubulin 0.0299 0.3015 0.2996
Echinococcus granulosus hexokinase 0.0094 0.0775 0.0772
Echinococcus granulosus tubulin beta 4A class IVa 0.0522 0.5455 0.5454
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0933 0.0931
Plasmodium vivax tubulin gamma chain, putative 0.0299 0.3015 0.2996
Echinococcus granulosus lamin 0.0027 0.004 0.0037
Schistosoma mansoni hexokinase 0.0094 0.0775 0.0775
Leishmania major alpha tubulin 0.042 0.434 0.4325
Echinococcus granulosus tubulin alpha chain 0.042 0.434 0.4339
Echinococcus granulosus peroxisome assembly protein 26 0.042 0.434 0.4339
Brugia malayi Tubulin alpha-2 chain 0.042 0.434 0.4325
Toxoplasma gondii beta tubulin 0.0522 0.5455 0.5443
Leishmania major alpha tubulin 0.042 0.434 0.4325
Giardia lamblia Beta tubulin 0.0522 0.5455 0.5443
Leishmania major hexokinase, putative 0.0094 0.0775 0.075
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0112 0.0109
Echinococcus multilocularis tubulin alpha 0.0299 0.3015 0.3013
Loa Loa (eye worm) hexokinase type II 0.0094 0.0775 0.075
Plasmodium falciparum tubulin epsilon chain, putative 0.0299 0.3015 0.2996
Trypanosoma brucei beta tubulin 0.0299 0.3015 0.2996
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0179 0.0153
Trypanosoma brucei unspecified product 0.0027 0.0046 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0933 0.0931
Brugia malayi hypothetical protein 0.0052 0.0314 0.0288
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0291 0.2922 0.2903
Schistosoma mansoni Smad4 0.0033 0.0112 0.0112
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0354 0.361 0.3609
Onchocerca volvulus 0.0094 0.0775 0.3194
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0743 0.786 0.7854
Echinococcus multilocularis tubulin subunit beta 0.0522 0.5455 0.5454
Brugia malayi Tubulin beta chain 0.0169 0.1597 0.1575
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.042 0.434 0.4325
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.026 0.2585 0.2565
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0886 0.0862
Trypanosoma brucei epsilon tubulin 0.0299 0.3015 0.2996
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.013 0.1167 0.1144
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0743 0.786 0.7854
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.026 0.2585 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.042 0.434 0.4339
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0285 0.0282
Trichomonas vaginalis tubulin alpha chain, putative 0.0299 0.3015 0.2996
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.0109
Echinococcus granulosus hexokinase 0.0094 0.0775 0.0772
Loa Loa (eye worm) hypothetical protein 0.0066 0.0472 0.0446
Echinococcus granulosus dna polymerase kappa 0.0039 0.0179 0.0176
Echinococcus granulosus Tubulin beta 2C chain 0.0522 0.5455 0.5454
Leishmania major DNA polymerase eta, putative 0.0039 0.0175 0.0149
Brugia malayi MH2 domain containing protein 0.0487 0.5065 0.5052
Echinococcus multilocularis lamin dm0 0.0027 0.004 0.0037
Schistosoma mansoni smad1 5 8 and 0.0033 0.0112 0.0112
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0112 0.0085
Leishmania major delta tubulin, putative 0.013 0.1167 0.1144
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0299 0.3015 0.2996
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0939 1 1
Brugia malayi Tubulin gamma chain 0.0299 0.3015 0.2996
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0886 0.0862
Giardia lamblia Epsilon tubulin 0.013 0.1167 0.1144
Schistosoma mansoni hypothetical protein 0.0699 0.7384 0.7384
Loa Loa (eye worm) hypothetical protein 0.0251 0.2492 0.2472
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0743 0.786 0.7854
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0285 0.0259
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Echinococcus granulosus tubulin subunit beta 0.0522 0.5455 0.5454
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0285 0.0259
Trypanosoma cruzi polyprenyl synthase, putative 0.0354 0.361 0.3593
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0008
Echinococcus granulosus tubulin subunit TubB 0.042 0.434 0.4339
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0285 0.0259
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0939 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0314 0.0288
Leishmania major alpha tubulin 0.042 0.434 0.4325
Brugia malayi tubulin alpha-2 chain 0.042 0.434 0.4325
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0526 0.0501
Leishmania major gamma-tubulin 0.0299 0.3015 0.2996
Plasmodium vivax tubulin alpha chain, putative 0.042 0.434 0.4325
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0285 0.0282
Loa Loa (eye worm) tubulin alpha chain 0.042 0.434 0.4325
Brugia malayi MH1 domain containing protein 0.0033 0.0112 0.0085
Mycobacterium tuberculosis Cell division protein FtsZ 0.013 0.1167 0.1006
Loa Loa (eye worm) transcription factor SMAD2 0.0487 0.5065 0.5052
Brugia malayi MH1 domain containing protein 0.0033 0.0112 0.0085
Loa Loa (eye worm) tubulin beta-2A chain 0.0522 0.5455 0.5443
Toxoplasma gondii alpha-tubulin I, putative 0.042 0.434 0.4325
Entamoeba histolytica tubulin gamma chain 0.0299 0.3015 0.5505
Brugia malayi MH2 domain containing protein 0.0033 0.0112 0.0085
Echinococcus multilocularis tubulin subunit TubB 0.042 0.434 0.4339
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0933 0.0933
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0179 0.0281
Echinococcus granulosus hexokinase 0.0094 0.0775 0.0772
Loa Loa (eye worm) tubulin gamma chain 0.0299 0.3015 0.2996
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0285 0.0282
Giardia lamblia Delta tubulin 0.013 0.1167 0.1144
Leishmania major alpha tubulin 0.042 0.434 0.4325
Trypanosoma cruzi zeta tubulin, putative 0.013 0.1167 0.1144
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.004 0.0013
Echinococcus granulosus Tubulin alpha 1 chain 0.042 0.434 0.4339
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0179 0.0176
Brugia malayi hexokinase 0.0094 0.0775 0.075
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.026 0.2585 0.245
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0019
Trichomonas vaginalis tubulin epsilon chain, putative 0.0522 0.5455 0.5443
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Schistosoma mansoni trans-prenyltransferase 0.026 0.2585 0.2585
Echinococcus multilocularis lamin 0.0027 0.004 0.0037
Schistosoma mansoni smad1 5 8 and 0.0033 0.0112 0.0112
Giardia lamblia Beta tubulin 0.0522 0.5455 0.5443
Brugia malayi Polyprenyl synthetase family protein 0.026 0.2585 0.2565
Trypanosoma cruzi tubulin delta chain 0.013 0.1167 0.1144
Brugia malayi Tubulin alpha chain 0.013 0.1167 0.1144
Loa Loa (eye worm) Smad1 0.0033 0.0112 0.0085
Loa Loa (eye worm) tubulin alpha-2 chain 0.042 0.434 0.4325
Trypanosoma brucei alpha tubulin 0.042 0.434 0.4325
Echinococcus multilocularis tubulin gamma 1 chain 0.0299 0.3015 0.3013
Brugia malayi tubulin alpha chain - mouse 0.042 0.434 0.4325
Brugia malayi Smad1 0.0033 0.0112 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0112 0.0085
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0354 0.361 0.361
Echinococcus multilocularis hexokinase 0.0094 0.0775 0.0772
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0285 0.0282
Echinococcus multilocularis tubulin epsilon chain 0.0299 0.3015 0.3013
Echinococcus granulosus Tubulin beta 2C chain 0.0522 0.5455 0.5454
Trypanosoma brucei alpha tubulin 0.042 0.434 0.4325
Schistosoma mansoni intermediate filament proteins 0.0027 0.004 0.004
Loa Loa (eye worm) alpha-tubulin 0.042 0.434 0.4325
Giardia lamblia Beta tubulin 0.0522 0.5455 0.5443
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0179 0.0153
Trichomonas vaginalis tubulin gamma chain, putative 0.0522 0.5455 0.5443
Loa Loa (eye worm) tubulin alpha chain 0.042 0.434 0.4325
Entamoeba histolytica tubulin alpha-1 chain 0.042 0.434 0.7946
Trypanosoma brucei tubulin delta chain 0.013 0.1167 0.1144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0285 0.0259
Plasmodium falciparum alpha tubulin 1 0.042 0.434 0.4325
Schistosoma mansoni lamin 0.0027 0.004 0.004
Brugia malayi Hexokinase family protein 0.0059 0.0393 0.0367
Trypanosoma brucei alpha tubulin 0.042 0.434 0.4325
Onchocerca volvulus 0.0094 0.0775 0.3194
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Echinococcus granulosus Tubulin beta 2C chain 0.0522 0.5455 0.5454
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0109 0.0107
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0179 0.0179
Schistosoma mansoni tubulin subunit epsilon 0.0299 0.3015 0.3015
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.0109
Plasmodium falciparum hexokinase 0.0094 0.0775 0.075
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0472 0.0446
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0109 0.0107
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.026 0.2585 0.2565
Loa Loa (eye worm) hexokinase 0.0094 0.0775 0.075
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0939 1 1
Loa Loa (eye worm) polyprenyl synthetase 0.0939 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.042 0.434 0.4339
Loa Loa (eye worm) hypothetical protein 0.0064 0.0449 0.0423
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Trypanosoma brucei tubulin gamma chain 0.0299 0.3015 0.2996
Echinococcus multilocularis Tubulin beta 2C chain 0.0522 0.5455 0.5454
Echinococcus granulosus smad 0.0033 0.0112 0.0109
Loa Loa (eye worm) pax transcription factor protein 2 0.0237 0.2341 0.232
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Echinococcus multilocularis beta tubulin 0.0522 0.5455 0.5454
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0939 1 1
Schistosoma mansoni tubulin subunit alpha 0.013 0.1167 0.1167
Echinococcus granulosus Tubulin beta 2C chain 0.0522 0.5455 0.5454
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.026 0.2585 0.2583
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Echinococcus multilocularis GPCR, family 2 0.0033 0.0109 0.0107
Trypanosoma brucei alpha tubulin 0.042 0.434 0.4325
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.1167 0.1144
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Echinococcus multilocularis smad 0.0033 0.0112 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1167 0.1144
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0285 0.0259
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Trichomonas vaginalis tubulin gamma chain, putative 0.0299 0.3015 0.2996
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.026 0.2585 0.245
Echinococcus granulosus alpha tubulin 0.042 0.434 0.4339
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Loa Loa (eye worm) hypothetical protein 0.0104 0.0886 0.0862
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0179 0.0153
Loa Loa (eye worm) tubulin beta chain 0.0522 0.5455 0.5443
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0179 0.0176
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0314 0.0288
Schistosoma mansoni smad 0.0033 0.0112 0.0112
Schistosoma mansoni glutathione synthetase 0.026 0.2585 0.2585
Brugia malayi hypothetical protein 0.0033 0.0114 0.0087
Treponema pallidum cell division protein FtsZ 0.013 0.1167 0.1384
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0314 0.0288
Leishmania major alpha tubulin 0.042 0.434 0.4325
Giardia lamblia Farnesyl diphosphate synthase 0.0939 1 1
Trichomonas vaginalis tubulin, putative 0.0169 0.1597 0.1575
Onchocerca volvulus 0.0169 0.1597 0.6767
Schistosoma mansoni alpha tubulin 0.042 0.434 0.434
Brugia malayi Cell division protein ftsZ 0.013 0.1167 0.1144
Entamoeba histolytica hexokinase 1 0.0094 0.0775 0.1378
Echinococcus granulosus tubulin alpha 3 chain 0.042 0.434 0.4339
Echinococcus multilocularis tubulin alpha 1C chain 0.042 0.434 0.4339
Echinococcus multilocularis tubulin alpha chain 0.042 0.434 0.4339
Echinococcus granulosus tubulin alpha chain 0.042 0.434 0.4339
Plasmodium vivax tubulin alpha chain, putative 0.042 0.434 0.4325
Echinococcus granulosus Tubulin alpha 1 chain 0.042 0.434 0.4339
Trypanosoma brucei epsilon tubulin 0.0299 0.3015 0.2996
Brugia malayi Tubulin beta chain 0.013 0.1167 0.1144
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.026 0.2585 0.245
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0049
Echinococcus granulosus tubulin delta chain 0.013 0.1167 0.1165
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.026 0.2585 0.2565
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0179 0.0176
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0285 0.0259
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Loa Loa (eye worm) polyprenyl synthetase 0.026 0.2585 0.2565
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.026 0.2585 0.2583
Leishmania major alpha tubulin 0.042 0.434 0.4325
Brugia malayi MH2 domain containing protein 0.0033 0.0112 0.0085
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Brugia malayi isocitrate dehydrogenase 0.0049 0.0285 0.0259
Echinococcus granulosus tubulin alpha chain 0.042 0.434 0.4339
Leishmania major alpha tubulin 0.042 0.434 0.4325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0109 0.0107
Trichomonas vaginalis tubulin alpha chain, putative 0.0169 0.1597 0.1575
Trichomonas vaginalis tubulin alpha chain, putative 0.0169 0.1597 0.1575
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.026 0.2585 1
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0314 0.0288
Schistosoma mansoni hypothetical protein 0.0108 0.0933 0.0933
Schistosoma mansoni alpha tubulin 0.042 0.434 0.434
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0314 0.0288
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0112 0.0109
Leishmania major alpha tubulin 0.042 0.434 0.4325
Schistosoma mansoni tubulin subunit gamma 0.0299 0.3015 0.3015
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Brugia malayi Tubulin alpha chain 0.042 0.434 0.4325
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0019
Echinococcus granulosus tubulin alpha chain 0.042 0.434 0.4339
Brugia malayi beta-tubulin, identical 0.0522 0.5455 0.5443
Onchocerca volvulus 0.0059 0.0393 0.1534
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) hexokinase 0.0059 0.0393 0.0367
Loa Loa (eye worm) hypothetical protein 0.042 0.434 0.4325
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.026 0.2585 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0285 0.0282
Trypanosoma cruzi epsilon tubulin, putative 0.0299 0.3015 0.2996
Schistosoma mansoni tubulin subunit beta 0.0522 0.5455 0.5455
Trypanosoma brucei zeta tubulin, putative 0.013 0.1167 0.1144
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0743 0.786 0.7854
Trypanosoma cruzi hexokinase, putative 0.0094 0.0775 0.075
Trypanosoma cruzi alpha tubulin, putative 0.042 0.434 0.4325
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) hypothetical protein 0.0071 0.0526 0.0501
Trypanosoma cruzi beta tubulin, putative 0.0522 0.5455 0.5443
Toxoplasma gondii alpha tubulin TUBA1 0.042 0.434 0.4325
Leishmania major farnesyl pyrophosphate synthase 0.0939 1 1
Schistosoma mansoni alpha tubulin 0.042 0.434 0.434
Echinococcus multilocularis tubulin alpha chain 0.042 0.434 0.4339
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.013 0.1167 0.1144
Echinococcus granulosus tubulin alpha 1C chain 0.042 0.434 0.4339
Trichomonas vaginalis tubulin alpha chain, putative 0.0522 0.5455 0.5443
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Leishmania major alpha tubulin 0.042 0.434 0.4325
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1167 0.1144
Echinococcus multilocularis peroxisome assembly protein 26 0.042 0.434 0.4339
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0285 0.0282
Loa Loa (eye worm) intermediate filament protein 0.0027 0.004 0.0013
Brugia malayi Hexokinase family protein 0.0094 0.0775 0.075
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0175 0.0149
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0472 0.0446
Leishmania major epsilon tubulin, putative 0.0299 0.3015 0.2996
Schistosoma mansoni DNA polymerase eta 0.0066 0.0472 0.0472
Trypanosoma brucei alpha tubulin, putative 0.0169 0.1597 0.1575
Schistosoma mansoni tubulin subunit alpha 0.042 0.434 0.434
Echinococcus multilocularis musashi 0.0027 0.004 0.0037
Schistosoma mansoni lamin 0.0027 0.004 0.004
Brugia malayi hexokinase type II 0.003 0.0075 0.0049
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.026 0.2585 0.5
Entamoeba histolytica hypothetical protein 0.0108 0.0933 0.167
Trypanosoma brucei hexokinase 0.0094 0.0775 0.075
Trichomonas vaginalis tubulin epsilon chain, putative 0.013 0.1167 0.1144
Brugia malayi Tubulin beta-1 chain 0.0522 0.5455 0.5443
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0285 0.0259
Entamoeba histolytica tubulin family protein 0.0522 0.5455 1
Echinococcus granulosus tubulin gamma 1 chain 0.0299 0.3015 0.3013
Loa Loa (eye worm) tubulin alpha 2 0.0291 0.2922 0.2903
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Loa Loa (eye worm) BEN-1 protein 0.0522 0.5455 0.5443
Trichomonas vaginalis tubulin, putative 0.0522 0.5455 0.5443
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0939 1 1
Schistosoma mansoni tubulin subunit beta 0.013 0.1167 0.1167
Leishmania major solanesyl-diphosphate synthase, putative 0.026 0.2585 0.2565
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.026 0.2585 0.4713
Entamoeba histolytica hypothetical protein 0.0108 0.0933 0.167
Mycobacterium ulcerans cell division protein FtsZ 0.013 0.1167 0.1006
Loa Loa (eye worm) tubulin beta-4 chain 0.0522 0.5455 0.5443
Leishmania major alpha tubulin 0.042 0.434 0.4325
Treponema pallidum octaprenyl-diphosphate synthase 0.0354 0.361 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.042 0.434 0.4325
Leishmania major beta tubulin 0.0522 0.5455 0.5443
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0285 0.0259
Loa Loa (eye worm) tubulin beta-1 chain 0.0522 0.5455 0.5443
Echinococcus multilocularis tubulin alpha chain 0.042 0.434 0.4339
Entamoeba histolytica hypothetical protein 0.0108 0.0933 0.167
Trypanosoma brucei beta tubulin 0.0522 0.5455 0.5443
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0179 0.0153
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.026 0.2585 0.2583
Trypanosoma brucei zeta tubulin 0.013 0.1167 0.1144
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.026 0.2585 0.2565
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0522 0.5455 0.5454
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0285 0.0259
Giardia lamblia Alpha-tubulin 0.042 0.434 0.4325
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0112 0.0109
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Leishmania major DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.026 0.2585 0.4713
Trypanosoma brucei unspecified product 0.0039 0.0179 0.0153
Echinococcus multilocularis tubulin delta chain 0.013 0.1167 0.1165
Onchocerca volvulus 0.0237 0.2341 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0354 0.361 0.3593
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0179 0.0153
Trichomonas vaginalis tubulin beta chain, putative 0.042 0.434 0.4325
Echinococcus multilocularis tubulin beta 1 chain 0.0522 0.5455 0.5454
Leishmania major alpha tubulin 0.042 0.434 0.4325
Echinococcus granulosus Tubulin beta 2C chain 0.0522 0.5455 0.5454
Echinococcus multilocularis tubulin alpha chain 0.042 0.434 0.4339
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0179 0.0153
Entamoeba histolytica tubulin family protein 0.0522 0.5455 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0886 0.0862
Schistosoma mansoni hypothetical protein 0.0023 0.0002 0.0002
Echinococcus multilocularis beta tubulin 0.0522 0.5455 0.5454
Echinococcus multilocularis tubulin alpha 1C chain 0.042 0.434 0.4339
Plasmodium vivax tubulin epsilon chain, putative 0.0299 0.3015 0.2996
Toxoplasma gondii beta-tubulin, putative 0.0522 0.5455 0.5443
Leishmania major zeta tubulin, putative 0.013 0.1167 0.1144

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 86.8 % In vitro inhibition of [3H]-U69,593 binding to Opioid receptor kappa 1 of guinea pig brain. ChEMBL. 2157008
Inhibition (binding) = 86.8 % In vitro inhibition of [3H]-U69,593 binding to Opioid receptor kappa 1 of guinea pig brain. ChEMBL. 2157008

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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