Detailed information for compound 1860739

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 993.912 | Formula: C48H51NO22
  • H donors: 5 H acceptors: 12 LogP: 3.06 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)[C@@H]1O[C@@H](Oc2ccccc2COC(=O)N[C@@H]2C[C@@H](O[C@H]([C@H]2O)C)O[C@H]2C[C@@](O)(Cc3c2c(O)c2c(c3O)C(=O)c3c(C2=O)c(OC)ccc3)C(=O)C)[C@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C48H51NO22/c1-19-36(54)27(49-47(60)64-18-24-11-8-9-13-28(24)70-46-44(68-23(5)53)42(67-22(4)52)41(66-21(3)51)43(71-46)45(59)63-7)15-31(65-19)69-30-17-48(61,20(2)50)16-26-33(30)40(58)35-34(38(26)56)37(55)25-12-10-14-29(62-6)32(25)39(35)57/h8-14,19,27,30-31,36,41-44,46,54,56,58,61H,15-18H2,1-7H3,(H,49,60)/t19-,27+,30-,31-,36+,41-,42-,43+,44-,46+,48-/m0/s1
  • InChiKey: VVTKZHRRSKQHJI-RZVPXLQISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0863 0.2555
Brugia malayi Protein kinase domain containing protein 0.0018 0.0014 0.0044
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0048 0.014 0.0272
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0062 0.0197 0.0382
Brugia malayi PXA domain containing protein 0.0021 0.0026 0.0079
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0218 0.0843 0.4449
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0164
Leishmania major hypothetical protein, unknown function 0.0075 0.0249 0.0653
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0025 0.0043 0.0084
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0366 0.1458 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0389 0.1118
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0165 0.0438
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0035 0.0034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0366 0.1458 0.4358
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0075 0.0145
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0195 0.0746 0.0746
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0366 0.1458 1
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0928 0.275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.1342 0.4007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0052 0.0157
Entamoeba histolytica hypothetical protein 0.0037 0.0091 0.0214
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0053 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.233 0.7019
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.002 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0108 0.0389 0.0389
Plasmodium vivax SET domain protein, putative 0.003 0.0064 0.0709
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0624 0.1669
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0024
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0326 0.1291 0.1291
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0326 0.1291 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0075 0.0249 0.3804
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.002 0.0039
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0075 0.0074
Entamoeba histolytica hypothetical protein 0.0672 0.2725 0.82
Onchocerca volvulus Serine\/threonine kinase homolog 0.0195 0.0746 0.5778
Loa Loa (eye worm) hypothetical protein 0.0102 0.0362 0.0798
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.006 0.0059
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0165 0.0624 0.1831
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0397 0.0773
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.002 0.002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0366 0.1458 0.4281
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0362 0.1091
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0052 0.0154 0.0434
Brugia malayi peptidase family M13 containing protein 0.0023 0.0036 0.011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0366 0.1458 0.4393
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0108 0.0389 0.0389
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0326 0.1293 0.3793
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0624 0.4668
Plasmodium vivax hypothetical protein 0.0075 0.0249 0.3767
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0863 0.2555
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0181 0.0692 0.1524
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0063 0.5
Echinococcus granulosus serine protein kinase ATM 0.0182 0.0693 0.0693
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0326 0.1291 0.3891
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0338 0.1343 0.9196
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0094 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0364 0.1042
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0178 0.0677 0.199
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0438 0.1754 0.5285
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0091 0.0177
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0165 0.0438
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0514
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1253 0.5134 0.5134
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0075 0.0249 0.0484
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Onchocerca volvulus 0.0102 0.0362 0.2803
Echinococcus granulosus intermediate filament protein 0.0027 0.0052 0.0052
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.002 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0357 0.1419 0.2764
Brugia malayi Csnk2b protein 0.0037 0.0094 0.0283
Brugia malayi phosphofructokinase 0.011 0.0397 0.1196
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0397 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0111
Loa Loa (eye worm) CYP4Cod1 0.002 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0089 0.031 0.0894
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.1218 0.3631
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0067
Onchocerca volvulus 0.0075 0.0249 0.1923
Echinococcus granulosus lamin 0.0027 0.0052 0.0052
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.1081 0.3216
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0148 0.0288
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0063 0.0693
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0063 0.013
Plasmodium vivax glycogen synthase kinase 3, putative 0.0052 0.0154 0.2202
Brugia malayi hypothetical protein 0.0037 0.0091 0.0275
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.002 0.002
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0181 0.0692 0.2084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0064 0.0064
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0022 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.0692
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0075 0.0249 0.1758
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0195 0.0746 0.0746
Brugia malayi Protein kinase domain containing protein 0.0326 0.1291 0.3891
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0934 0.2058
Echinococcus granulosus casein kinase ii subunit alpha 0.0139 0.0516 0.0516
Onchocerca volvulus 0.0238 0.0928 0.7187
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0053 0.0103
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0397 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0326 0.1293 0.1293
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0039
Echinococcus granulosus expressed conserved protein 0.0166 0.0626 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0596 0.2409 0.7239
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0167 0.0632 0.1843
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0249 0.0548
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0154 0.0406
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Onchocerca volvulus 0.0075 0.0249 0.1923
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0815 0.3319 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0053 0.0099
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0144 0.0281
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0047
Loa Loa (eye worm) calcium channel 0.0033 0.0075 0.0164
Loa Loa (eye worm) phosphatidylinositol 3 0.0286 0.1126 0.2481
Brugia malayi hypothetical protein 0.0166 0.0627 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Loa Loa (eye worm) hypothetical protein 0.0075 0.0249 0.0548
Onchocerca volvulus 0.0098 0.0344 0.2661
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0063 0.0748
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0075 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.031 0.1227 0.3656
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0165 0.0624 0.1831
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0452 0.1815 1
Brugia malayi Serotonin receptor 0.0473 0.1902 0.5731
Entamoeba histolytica casein kinase, putative 0.0139 0.0516 0.1502
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0154 0.034
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0036 0.0071
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0115 0.0286
Loa Loa (eye worm) hypothetical protein 0.0574 0.232 0.511
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0182 0.0693 0.2024
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0094 0.0234
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0183 0.0698 0.5239
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0195 0.0746 0.1999
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0094 0.056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Loa Loa (eye worm) hypothetical protein 0.0166 0.0627 0.138
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0065 0.0143
Loa Loa (eye worm) hypothetical protein 0.0478 0.1921 0.4232
Brugia malayi FAT domain containing protein 0.0108 0.0389 0.1173
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0165 0.0624 0.0624
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0053 0.0099
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0091 0.0091
Trypanosoma cruzi target of rapamycin kinase 3 0.0338 0.1343 0.394
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Brugia malayi Casein kinase II, alpha chain 0.0139 0.0516 0.1555
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0 0.000000015677
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0165 0.0624 0.1216
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0075 0.0249 0.0692
Leishmania major phosphatidylinositol 3-kinase, putative 0.0165 0.0624 0.1669
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0397 1
Loa Loa (eye worm) phosphofructokinase 0.011 0.0397 0.0875
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0397 0.1142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0326 0.1293 0.3895
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0366 0.1458 0.4358
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0052 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0067
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0075 0.0249 0.0712
Loa Loa (eye worm) hypothetical protein 0.0108 0.0389 0.0857
Schistosoma mansoni lamin 0.0027 0.0052 0.0101
Brugia malayi Cytochrome P450 family protein 0.002 0.0021 0.0064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0308 0.1218 0.3631
Mycobacterium ulcerans putative regulatory protein 0.002 0.0022 0.0007
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.002 0.0061
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0075 0.0074
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0094 0.0223
Schistosoma mansoni hypothetical protein 0.0166 0.0626 0.1219
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.002 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0249 0.6045
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0053 0.016
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0091 0.1861
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0503 0.0979
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.002 0.0061
Brugia malayi hypothetical protein 0.0478 0.1921 0.5788
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0366 0.1458 0.1458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0863 0.2555
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0286 0.1126 0.7691
Schistosoma mansoni hypothetical protein 0.0108 0.0389 0.0758
Plasmodium falciparum glycogen synthase kinase 3 0.0052 0.0154 0.2248
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0165 0.0624 0.0624
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0136 0.0503 0.1107
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0039
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0096 0.0337 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0286 0.1126 0.3353
Echinococcus granulosus axis inhibition protein axin 0.0019 0.002 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.1218 0.3631
Echinococcus multilocularis serine protein kinase ATM 0.0182 0.0693 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0197 0.0534
Giardia lamblia GTOR 0.0366 0.1458 0.7964
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0573 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3567
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0075 0.0074
Toxoplasma gondii hypothetical protein 0.0054 0.0165 0.111
Schistosoma mansoni ankyrin 23/unc44 0.0015 0 0.000000030537
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0063 0.013
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.002 0.002
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Brugia malayi Cytochrome P450 family protein 0.002 0.0021 0.0064
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0624 0.4196
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0698 0.2054
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Leishmania major hypothetical protein, conserved 0.0909 0.3706 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0355 0.1409 0.421
Trypanosoma brucei polo-like protein kinase 0.0195 0.0746 0.5046
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0075 0.0249 0.1582
Trichomonas vaginalis PIKK family atypical protein kinase 0.031 0.1227 0.3656
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0039
Brugia malayi Cytochrome P450 family protein 0.003 0.0065 0.0195
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0075 0.0249 0.1758
Brugia malayi Uncoordinated protein 44 0.0015 0 0.0001
Brugia malayi intracellular kinase 0.0052 0.0154 0.0465
Schistosoma mansoni endothelin-converting enzyme-related 0.0023 0.0036 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0035 0.0076
Echinococcus multilocularis high voltage activated calcium channel beta 0.0088 0.0305 0.0304
Brugia malayi hypoxia-induced factor 1 0.0153 0.0573 0.1727
Echinococcus multilocularis endothelin converting enzyme 1 0.0096 0.0337 0.0337
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0029 0.0025
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0308 0.1218 0.3573
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.0692
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.0233 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.1342 0.4007
Brugia malayi Peptidase family M13 containing protein 0.0096 0.0337 0.1015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0125
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.1458 0.4358
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.002 0.0061
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0075 0.0249 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0154 0.0406
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0029 0.0087
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.0141 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0091 0.0091
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.002 0.0039
Onchocerca volvulus 0.0052 0.0154 0.1193
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0345 0.0984
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1253 0.5134 0.5134
Giardia lamblia Kinase, PLK 0.0195 0.0746 0.39
Loa Loa (eye worm) hypothetical protein 0.0107 0.0384 0.0847
Loa Loa (eye worm) RecQ helicase 0.0021 0.0029 0.0063
Onchocerca volvulus 0.0027 0.0052 0.0403
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0094 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.1342 0.4007
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Brugia malayi PXA domain containing protein 0.0021 0.0026 0.0079
Schistosoma mansoni hypothetical protein 0.0171 0.0647 0.1259
Brugia malayi Protein kinase domain containing protein 0.0136 0.0503 0.1514
Giardia lamblia Phosphatidylinositol 4-kinase 0.0075 0.0249 0.1058
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0176 0.0668 0.0668
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0052 0.0154 0.0154
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0315 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0323 0.0917
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0091 0.0275
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0337 0.0656
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0397 0.0397
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0249 0.0548
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0197 0.0196
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0075 0.0249 0.0692
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0023 0.0036 0.0071
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0063 0.0323
Schistosoma mansoni survival motor neuron protein 0.0098 0.0344 0.0669
Entamoeba histolytica serine/threonine protein kinase, putative 0.0195 0.0746 0.2201
Brugia malayi hypothetical protein 0.0019 0.002 0.0061
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0094 0.0094
Echinococcus granulosus protein kinase shaggy 0.0052 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0 0.0001
Plasmodium falciparum casein kinase 2, alpha subunit 0.0139 0.0516 0.8214
Loa Loa (eye worm) hypothetical protein 0.0287 0.113 0.2489
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0094 0.0207
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0197 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3566
Schistosoma mansoni kinase 0.01 0.0355 0.0692
Onchocerca volvulus 0.0027 0.0052 0.0403
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.1291 0.2845
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0165 0.0624 0.1216
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0165 0.0624 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0052 0.0101
Echinococcus multilocularis expressed conserved protein 0.0166 0.0626 0.0626
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0338 0.1343 0.3611
Loa Loa (eye worm) hypothetical protein 0.005 0.0148 0.0326
Loa Loa (eye worm) hypothetical protein 0.0096 0.0337 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.0632 0.1853
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0182 0.0693 0.4677
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0234 0.0909 0.2662
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0249 0.3767
Brugia malayi follicle stimulating hormone receptor 0.024 0.0934 0.2815
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0094 0.0256
Loa Loa (eye worm) zinc metallopeptidase 4 0.0023 0.0036 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0815 0.3319 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0249 0.0692
Echinococcus multilocularis lamin 0.0027 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0115
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0154 0.0519
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0075 0.0249 0.0484
Schistosoma mansoni hypothetical protein 0.0052 0.0155 0.0302
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0326 0.1293 0.3793
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0139 0.0516 0.1137
Brugia malayi SH2 domain containing protein 0.069 0.28 0.8434
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0021 0.0047
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0165 0.0624 0.1831
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.3767
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0815 0.3319 1
Schistosoma mansoni hypothetical protein 0.0171 0.0647 0.1259
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0746 0.2181
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0075 0.0074
Echinococcus multilocularis 0.0075 0.0249 0.0248
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.1291 0.2845
Brugia malayi intermediate filament protein 0.0027 0.0052 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0249 0.0692
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0094 0.0505
Entamoeba histolytica hypothetical protein 0.0182 0.0693 0.204
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.0233 0.0514
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0672 0.2725 0.82
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0064 0.0331
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Trypanosoma cruzi casein kinase II, putative 0.0139 0.0516 0.1501
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0154 0.0519
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.002 0.002
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0094 0.12
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0167 0.0632 0.0631
Leishmania major phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.0653
Schistosoma mansoni neprilysin 0.0025 0.0043 0.0084
Onchocerca volvulus 0.0037 0.0091 0.0705
Echinococcus multilocularis protein kinase shaggy 0.0052 0.0154 0.0154
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.0712
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0741 0.3011 0.9064
Schistosoma mansoni axis inhibition protein axin 0.0019 0.002 0.0039
Echinococcus multilocularis expressed protein 0.0379 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0154 0.0406
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.013 0.048 0.3194
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.002 0.0045
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0075 0.0145
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0315 0.0612
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2427 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0165 0.0624 0.0624
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.002 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0258 0.1009 0.2996
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0514
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0315 0.0612
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0063 0.0748
Loa Loa (eye worm) hypothetical protein 0.0102 0.0363 0.0799
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0397 1
Loa Loa (eye worm) gastrulation defective protein 1 0.0132 0.0488 0.1076
Toxoplasma gondii FATC domain-containing protein 0.0182 0.0693 0.5202
Echinococcus granulosus axis inhibition protein axin 0.0019 0.002 0.002
Leishmania major phosphatidylinositol 3-kinase, putative 0.0275 0.1081 0.2904
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0064 0.0064
Echinococcus multilocularis musashi 0.0027 0.0052 0.0052
Echinococcus granulosus lamin dm0 0.0027 0.0052 0.0052
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0629 0.2546 0.5609
Schistosoma mansoni fkbp-rapamycin associated protein 0.0167 0.0632 0.123
Loa Loa (eye worm) hypothetical protein 0.0167 0.0632 0.1391
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0075 0.0249 0.0749
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0397 0.2616
Trypanosoma brucei protein kinase, putative 0.0052 0.0154 0.0925
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0075 0.0225
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0315 0.0314
Giardia lamblia Kinase, CMGC CK2 0.0139 0.0516 0.2585
Brugia malayi 6-phosphofructokinase 0.011 0.0397 0.1196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0246 0.0959 0.2845
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0596 0.2409 0.7239
Giardia lamblia Casein kinase II beta chain 0.0037 0.0094 0.0175
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0029 0.0029
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.002 0.002
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.002 0.002
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0094 0.0725
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0112 0.0217
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.0692
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0211 0.0814 0.5518
Echinococcus multilocularis tumor protein p63 0.0343 0.1362 0.1361
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0344 0.1036
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0052 0.0154 0.03
Loa Loa (eye worm) phosphatidylinositol 3 0.111 0.454 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0063 0.0323
Echinococcus multilocularis geminin 0.0171 0.0647 0.0646
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Giardia lamblia Hypothetical protein 0.0075 0.0249 0.1058
Brugia malayi 6-phosphofructokinase 0.011 0.0397 0.1196
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0063 0.0323
Echinococcus multilocularis casein kinase ii subunit alpha 0.0139 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0183 0.0698 0.1538
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0036 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0323 0.0917
Schistosoma mansoni single-minded 0.0049 0.0144 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0035 0.0067
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0197 0.1219
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0746 0.2181
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.002 0.002
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0165 0.0624 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0197 0.0534
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0035 0.0034
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0397 0.1151
Trypanosoma cruzi hypothetical protein, conserved 0.0834 0.3397 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.0893 0.2644
Onchocerca volvulus 0.005 0.0148 0.1143
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0053 0.016
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0182 0.0693 0.135
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0035 0.0076
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Toxoplasma gondii target of rapamycin (TOR), putative 0.0331 0.1313 1
Mycobacterium ulcerans putative regulatory protein 0.002 0.0022 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Loa Loa (eye worm) RGS-3 protein 0.0019 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Entamoeba histolytica protein kinase domain containing protein 0.0139 0.0516 0.1502
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0075 0.0249 0.0248
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.014 0.0272
Echinococcus granulosus bloom syndrome protein 0.0021 0.0029 0.0029
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0094 0.0182
Brugia malayi hypothetical protein 0.0102 0.0363 0.1093
Mycobacterium leprae probable zinc metalloprotease 0.0096 0.0337 0.8393
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0023 0.0036 0.0071
Toxoplasma gondii CMGC kinase, CK2 family 0.0139 0.0516 0.3829
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0397 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3566
Schistosoma mansoni lamin 0.0027 0.0052 0.0101
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.1921 0.1921
Brugia malayi PAS domain containing protein 0.0049 0.0144 0.0435
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0052 0.0154 0.0398
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Leishmania major phosphatidylinositol kinase related protein, putative 0.0089 0.031 0.0819
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0165 0.0624 0.1881
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0366 0.1458 0.4281
Loa Loa (eye worm) phosphatidylinositol 3 0.0366 0.1458 0.3212
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0326 0.1293 0.1293
Echinococcus granulosus tumor protein p63 0.0343 0.1362 0.1361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0052 0.0115
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.025 0.0249
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0125
Leishmania major phosphatidylinositol kinase, putative 0.0075 0.0249 0.0653
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0075 0.0249 0.1758
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Echinococcus granulosus geminin 0.0171 0.0647 0.0646
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.002 0.002
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.002 0.002
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0165 0.0624 0.1831
Loa Loa (eye worm) hypothetical protein 0.0047 0.0136 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0045
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0075 0.0249 0.0248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.1218 0.367
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0029 0.0025
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0165 0.0624 0.0624
Schistosoma mansoni neprilysin-2 (M13 family) 0.0048 0.014 0.0272
Echinococcus granulosus single minded 2 0.0037 0.0091 0.0091
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0091 0.0091
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0064 0.0125
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0063 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0075 0.0249 0.0484
Toxoplasma gondii peptidase family M13 protein 0.0096 0.0337 0.2441
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0075 0.0074
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0624 0.1821
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0094 0.0725
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0075 0.0145
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.1921 0.1921
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0815 0.3319 0.9772
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.002 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.1081 0.3216
Echinococcus multilocularis cyclin dependent kinase 19 0.0136 0.0503 0.0502
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0286 0.1126 0.3026
Entamoeba histolytica protein kinase, putative 0.0052 0.0154 0.0406
Echinococcus granulosus cyclin dependent kinase 19 0.0136 0.0503 0.0502
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0062 0.0197 0.1219
Brugia malayi Pre-SET motif family protein 0.003 0.0064 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.1342 0.4007
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0075 0.0074
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0075 0.0249 0.0692
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0197 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.002 0.002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0094 0.1253
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0397 0.1142
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0397 0.1142
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.001 0.0019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0107 0.0384 0.1113
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0909 0.2003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0693 0.204
Brugia malayi Death domain containing protein 0.0015 0 0.0001
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0062 0.0197 0.0534
Loa Loa (eye worm) hypothetical protein 0.0096 0.0337 0.0742
Loa Loa (eye worm) hypothetical protein 0.0096 0.0337 0.0742
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0167 0.0632 0.0631
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0366 0.1458 0.1458
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0326 0.1293 0.2518
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1253 0.5134 1
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.1291 0.2515
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0075 0.0249 0.0484
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0397 0.1054
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0165 0.0624 0.1831
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0088 0.0305 0.0593
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0815 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0326 0.1291 0.1291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3567
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0052 0.0154 0.0154
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0397 0.0875
Entamoeba histolytica protein kinase rad3, putative 0.0167 0.0632 0.1853
Onchocerca volvulus 0.0042 0.0112 0.0864
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0075 0.0249 0.0749
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0514
Echinococcus granulosus expressed protein 0.0379 0.151 0.151
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.1218 0.3631
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0275 0.1081 0.7377
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0808 0.1779
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0075 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.1458 0.4358
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0516 0.1502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.0632 0.1903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.1081 0.3216
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.002 0.0039
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0176 0.0668 0.0668
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0249 0.0548
Entamoeba histolytica hypothetical protein 0.0037 0.0091 0.0214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0693 0.2089
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0094 0.0223
Loa Loa (eye worm) hypothetical protein 0.069 0.28 0.6166
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0139 0.0516 0.8204
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.0712
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0026 0.0058
Brugia malayi serine/threonine-protein kinase plk-2 0.0195 0.0746 0.2249
Schistosoma mansoni hypothetical protein 0.0037 0.0091 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0197 0.0196
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0071 0.0233 0.0514
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0746 0.2201
Brugia malayi Angiotensin-converting enzyme family protein 0.0629 0.2546 0.7671
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0624 0.4668
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0366 0.1458 0.284
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0574 0.232 0.232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.1081 0.3216
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0397 0.1142
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0094 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0035 0.0104
Trypanosoma brucei Casein kinase II 0.0139 0.0516 0.3443
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0094 0.12
Onchocerca volvulus 0.0102 0.0362 0.2803
Loa Loa (eye worm) hypothetical protein 0.0072 0.024 0.0529
Mycobacterium ulcerans zinc metalloprotease 0.0096 0.0337 0.8394
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0345 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0096 0.0337 0.8393
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0249 0.0548
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0039
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Toxoplasma gondii ck2 beta subunit 0.0037 0.0094 0.056
Schistosoma mansoni axis inhibition protein axin 0.0019 0.002 0.0039
Brugia malayi Pre-SET motif family protein 0.0209 0.0808 0.2434
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0154 0.034
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0397 0.1142
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0366 0.1458 0.3923
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0036 0.0071
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0165 0.0438
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.1582
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0338 0.1342 0.4007
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0084
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0815 0.3319 1
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0746 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1197 0.3567
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0052 0.0154 0.1028
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0063 0.0693
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0075 0.0249 0.0248
Schistosoma mansoni protein kinase 0.0139 0.0516 0.1005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0022 0.0059
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0021 0.0042
Plasmodium vivax unspecified product 0.0139 0.0516 0.8204
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0165 0.0624 0.1375
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.025 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0003
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Echinococcus granulosus endothelin converting enzyme 1 0.0096 0.0337 0.0337
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0062 0.0197 0.0559
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0075 0.0249 0.3804
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0075 0.0249 0.0712
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0115 0.0286
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.3352 0.3352
Schistosoma mansoni hypothetical protein 0.0098 0.0344 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0677 0.199
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Entamoeba histolytica hypothetical protein 0.0037 0.0091 0.0214
Echinococcus granulosus high voltage activated calcium channel beta 0.0088 0.0305 0.0304
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0115 0.0317
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0094 0.0256
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0815 0.3319 0.9772
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0397 0.0397
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0048 0.014 0.0272
Onchocerca volvulus 0.0047 0.0136 0.1055
Loa Loa (eye worm) phosphatidylinositol kinase 0.0075 0.0249 0.0548
Entamoeba histolytica hypothetical protein 0.0037 0.0091 0.0214
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.014 0.0272
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0062 0.0197 0.0534
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0075 0.0249 0.3767
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0075 0.0249 0.0749
Leishmania major casein kinase II, putative 0.0139 0.0516 0.1376
Echinococcus multilocularis lamin dm0 0.0027 0.0052 0.0052
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0397 0.0875
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0397 0.1142
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0624 0.1821
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0021 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.002 0.002
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0574 0.232 0.232
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0154 0.0406
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0195 0.0746 0.1644
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0366 0.1458 0.3923
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0001
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0 0.000000015677
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0249 0.6045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0122
Brugia malayi hypothetical protein 0.0019 0.002 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0063 0.013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0385 0.1535 0.4591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.1458 0.4358
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0197 0.0534
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0075 0.0249 0.0248
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0397 0.0773
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0075 0.0249 0.3767
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0308 0.1218 0.833
Leishmania major cytochrome p450-like protein 0.002 0.0021 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1313 0.3918
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0075 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0094 0.0223

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.5 uM Inhibitory activity was measured against murine L1210 leukemia cells. ChEMBL. 9733483

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9733483

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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