Detailed information for compound 204486

Basic information

Technical information
  • TDR Targets ID: 204486
  • Name: 4-chloro-5-(3-fluoro-4-methoxyphenyl)-1-(4-me thylsulfonylphenyl)imidazole
  • MW: 380.821 | Formula: C17H14ClFN2O3S
  • H donors: 0 H acceptors: 3 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1F)c1c(Cl)ncn1c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C17H14ClFN2O3S/c1-24-15-8-3-11(9-14(15)19)16-17(18)20-10-21(16)12-4-6-13(7-5-12)25(2,22)23/h3-10H,1-2H3
  • InChiKey: YVZIBNGIENXYSE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-5-(3-fluoro-4-methoxy-phenyl)-1-(4-methylsulfonylphenyl)imidazole
  • 4-chloro-5-(3-fluoro-4-methoxy-phenyl)-1-(4-mesylphenyl)imidazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0426 0.1292
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0046 0.014
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0199 0.1525 0.466
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0176 0.0571
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0019 0.0046
Trypanosoma cruzi AMP deaminase, putative 0.0106 0.0761 0.2318
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0031 0.0146 0.0434
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0184 0.0563
Echinococcus granulosus tar DNA binding protein 0.0062 0.0399 0.122
Trypanosoma cruzi hypothetical protein, conserved 0.013 0.0957 0.292
Mycobacterium ulcerans hypothetical protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0046 0.0139
Brugia malayi chloride channel protein 7 0.0031 0.0146 0.0445
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0026 0.0108 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0264 0.0808
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Brugia malayi Dopamine receptor 0.0013 0 0.0001
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0184 0.0563
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0 0.0001
Brugia malayi hypothetical protein 0.0013 0 0.0001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0048 0.0147
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0399 0.1219
Echinococcus granulosus neuropeptide Y receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Onchocerca volvulus 0.0014 0.0004 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0034 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0271 0.082
Onchocerca volvulus 0.0035 0.018 0.1009
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0061 0.0185
Trypanosoma cruzi chloride channel protein, putative 0.0031 0.0146 0.0434
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Mycobacterium ulcerans putative regulatory protein 0.0035 0.018 0.054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0 0.0001
Echinococcus granulosus protein jagged 1 0.0021 0.0061 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0034 0.0105
Trypanosoma cruzi chloride channel protein, putative 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0412 0.3268 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0106 0.0761 0.2318
Mycobacterium ulcerans cystathionine beta-synthase 0.0031 0.0146 0.0434
Echinococcus granulosus geminin 0.0165 0.1246 0.3814
Echinococcus multilocularis notch 0.0021 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0305 0.2393 0.7323
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0031 0.0146 0.0434
Toxoplasma gondii CBS domain-containing protein 0.0031 0.0146 0.0434
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0131 0.0401
Echinococcus granulosus neuropeptides capa receptor 0.0013 0 0.0001
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0031 0.0146 0.0445
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0271 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0048 0.0048
Onchocerca volvulus 0.0063 0.0413 0.2311
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0445
Schistosoma mansoni tyrosine kinase 0.0042 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0445
Toxoplasma gondii CBS family protein 0.0031 0.0146 0.0434
Brugia malayi Peroxidasin 0.0063 0.0413 0.1263
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.014
Brugia malayi nuclear hormone receptor 0.0017 0.0034 0.0105
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0 0.0001
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0061 0.0185
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0031 0.0146 0.0434
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0046
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0 0.0001
Schistosoma mansoni peter pan-related 0.0061 0.0389 0.0389
Echinococcus multilocularis fmrfamide receptor 0.0013 0 0.0001
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) Notch2 0.0021 0.0061 0.0185
Brugia malayi nuclear receptor NHR-88 0.0017 0.0034 0.0105
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0114 0.0823 0.2508
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0059
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0426 0.1302
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0032 0.0085
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0074 0.0074
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0413 0.1262
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0034 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0048 0.0048
Brugia malayi hypothetical protein 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0034 0.0105
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0031 0.0146 0.0434
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0061 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Entamoeba histolytica protein kinase, putative 0.0029 0.0134 0.172
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.003 0.0135 0.0413
Brugia malayi neuropeptide F receptor 0.0013 0 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0034 0.0192
Leishmania major AMP deaminase, putative 0.0106 0.0761 0.2318
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0116 0.084 0.2571
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0032 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0011
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0412 0.3268 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0166 0.0508
Schistosoma mansoni protein kinase subunit gamma 0.0134 0.0992 0.0992
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0113 0.0336
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0413 0.1263
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0182 0.0557
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0046 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0 0.0001
Echinococcus granulosus single minded 2 0.0035 0.018 0.0551
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0046
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0114 0.0823 0.2508
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0271 0.082
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Echinococcus multilocularis serotonin receptor 0.0013 0 0.0001
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0114 0.0823 0.2508
Brugia malayi Latrophilin receptor protein 2 0.0016 0.002 0.006
Onchocerca volvulus 0.0029 0.0131 0.0733
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.014
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0 0.0001
Schistosoma mansoni lamin 0.0026 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0182 0.0557
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.173 0.173
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0271 0.3536
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Echinococcus granulosus tyrosine protein kinase HCK 0.0029 0.0134 0.041
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.006
Echinococcus multilocularis peter pan 0.0061 0.0389 0.119
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0426 0.1401
Loa Loa (eye worm) IMP dehydrogenase 1 0.0412 0.3268 1
Brugia malayi G protein-coupled receptor 0.0013 0 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.002 0.0059
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0046 0.0139
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0113 0.1448
Loa Loa (eye worm) brix domain-containing protein 0.0061 0.0389 0.1189
Echinococcus granulosus expressed protein 0.0364 0.2875 0.8796
Echinococcus multilocularis neuropeptide s receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Leishmania major inosine-5-monophosphate dehydrogenase 0.0412 0.3268 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus multilocularis neuropeptide receptor 0.0013 0 0.0001
Echinococcus granulosus g protein coupled receptor 0.0013 0 0.0001
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.004 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0034 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0537
Leishmania major pyruvate kinase 0.0065 0.0426 0.1292
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0271 0.082
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0031 0.0146 0.0445
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0176 0.0537
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0113 0.0336
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0381 0.3015 1
Onchocerca volvulus 0.0063 0.0413 0.2311
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0103 0.0739 0.2261
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0271 0.083
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0213 0.1636 0.4999
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0165 0.1246 0.1246
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0399 0.122
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0381 0.1157
Schistosoma mansoni pyruvate kinase 0.0065 0.0426 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0034 0.0105
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0121
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0108 0.0331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0046
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0022 0.0074 0.0228
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0031 0.0146 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.051
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0031 0.0146 0.0434
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0281 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.013 0.0957 0.292
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0034 0.0105
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0 0.0001
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0305 0.2393 0.7323
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0057
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.004 0.0122
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0106 0.0761 0.2318
Echinococcus multilocularis tyrosine protein kinase HCK 0.0029 0.0134 0.041
Schistosoma mansoni chloride channel protein 0.0031 0.0146 0.0146
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0048 0.0147
Brugia malayi pyruvate kinase 0.0014 0.0005 0.0015
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0113 0.0336
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.006
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1048 0.1048
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0 0.0001
Echinococcus multilocularis somatostatin receptor 0.0013 0 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Echinococcus multilocularis pyruvate kinase 0.0065 0.0426 0.1302
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0305 0.2393 0.732
Echinococcus multilocularis allatostatin A receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Brugia malayi Brix domain containing protein 0.0061 0.0389 0.119
Brugia malayi intermediate filament protein 0.0026 0.0108 0.0331
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.0055 0.0344 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Brugia malayi hypothetical protein 0.0019 0.0046 0.014
Echinococcus granulosus allatostatin A receptor 0.0013 0 0.0001
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0031 0.0146 0.0146
Brugia malayi larval opioid receptor 0.0013 0 0.0001
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0031 0.0146 0.0434
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0305 0.2393 0.7323
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0004 0.0012
Onchocerca volvulus Dual oxidase homolog 0.0063 0.0413 0.2311
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0426 0.1302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0 0.0001
Brugia malayi Serotonin receptor 0.0013 0 0.0001
Entamoeba histolytica brix domain containing protein 0.0061 0.0389 0.5087
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0034 0.0105
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Mycobacterium ulcerans hypothetical protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0034 0.0105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0381 0.1157
Plasmodium falciparum BRIX domain, putative 0.0061 0.0389 0.1279
Brugia malayi neuropeptide F receptor 0.0013 0 0.0001
Trypanosoma cruzi GMP reductase 0.0412 0.3268 1
Brugia malayi hypothetical protein 0.0013 0 0.0001
Loa Loa (eye worm) TK protein kinase 0.0036 0.0184 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Leishmania major pyruvate kinase 0.0065 0.0426 0.1292
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0034 0.0034
Brugia malayi notch-like transmembrane receptor 0.0021 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0413 0.1263
Schistosoma mansoni coup transcription factor 0.0017 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.013 0.0957 0.292
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0116 0.084 0.2571
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0479
Echinococcus granulosus sex peptide receptor 0.0013 0 0.0001
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0106 0.0761 0.2318
Leishmania major peter pan protein, putative 0.0061 0.0389 0.1179
Brugia malayi Cadherin domain containing protein 0.0021 0.0061 0.0185
Onchocerca volvulus Slit protein homolog 0.0021 0.0061 0.0338
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0046
Giardia lamblia Rrm3p helicase 0.0027 0.0113 0.0567
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0113 0.0347
Schistosoma mansoni AMP deaminase 0.0106 0.0761 0.0761
Schistosoma mansoni lamin 0.0026 0.0108 0.0108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0 0.0001
Echinococcus granulosus g-protein coupled receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.1095 0.3352
Entamoeba histolytica hypothetical protein 0.0035 0.0182 0.2357
Onchocerca volvulus 0.0021 0.0061 0.0338
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0381 0.3015 1
Schistosoma mansoni slit 0.0021 0.0061 0.0061
Onchocerca volvulus Alicorn homolog 0.0048 0.0287 0.1608
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0032 0.0096
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.0055 0.0344 0.1043
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0034 0.0105
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Echinococcus granulosus protein jagged 2 0.0021 0.0061 0.0185
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.0413 0.1262
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0022 0.0074 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0413 0.1262
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.1048 0.3206
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Brugia malayi adenosine monophosphate deaminase 0.0106 0.0761 0.2327
Echinococcus multilocularis pyruvate kinase 0.0065 0.0426 0.1302
Echinococcus granulosus tyrosine kinase 0.0036 0.0184 0.0563
Echinococcus multilocularis pyruvate kinase 0.0051 0.0313 0.0959
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0031 0.0146 0.0434
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Brugia malayi Delta serrate ligand family protein 0.0021 0.0061 0.0185
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0412 0.3268 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1048 0.1048
Loa Loa (eye worm) notch protein 0.0021 0.0061 0.0185
Echinococcus multilocularis orexin receptor type 2 0.0013 0 0.0001
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0413 0.1262
Echinococcus granulosus somatostatin receptor 0.0013 0 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.002 0.006
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0022 0.0074 0.0216
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0013 0 0.0001
Onchocerca volvulus Peter pan protein homolog 0.0061 0.0389 0.2177
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0 0.0001
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0134 0.0992 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0426 0.1302
Plasmodium falciparum protein MAM3, putative 0.0031 0.0146 0.0471
Toxoplasma gondii IMP dehydrogenas 0.0412 0.3268 1
Schistosoma mansoni phospholipase C beta 0.0017 0.0032 0.0032
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0022 0.0074 0.0216
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0031 0.0146 0.0146
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0022 0.0074 0.0216
Plasmodium vivax SET domain protein, putative 0.0029 0.0131 0.0423
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0412 0.3268 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0042 0.0233 0.0713
Onchocerca volvulus 0.0231 0.1785 1
Trypanosoma brucei AMP deaminase, putative 0.0106 0.0761 0.2318
Loa Loa (eye worm) hypothetical protein 0.0022 0.0074 0.0227
Trypanosoma brucei brix domain containing protein, putative 0.0061 0.0389 0.1179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0131
Onchocerca volvulus Putative GMP reductase 0.0168 0.1272 0.7127
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0271 0.082
Echinococcus granulosus peroxidasin 0.0063 0.0413 0.1263
Echinococcus multilocularis AMP deaminase 2 0.0106 0.0761 0.2327
Brugia malayi loechrig isoform VII 0.0134 0.0992 0.3035
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0116 0.084 0.2571
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0034 0.0192
Echinococcus multilocularis geminin 0.0165 0.1246 0.3814
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus granulosus peter pan 0.0061 0.0389 0.119
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.084 0.084
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0412 0.3268 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.014
Trypanosoma brucei AMP deaminase, putative 0.0106 0.0761 0.2318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.0055 0.0344 0.3046
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0042 0.0233 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0034 0.0105
Brugia malayi bHLH-PAS transcription factor 0.0035 0.018 0.0551
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0046 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0381 0.0381
Trypanosoma cruzi hypothetical protein 0.013 0.0957 0.292
Echinococcus granulosus neuropeptide receptor 0.0013 0 0.0001
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0128 0.0938 0.287
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0032 0.0085
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Toxoplasma gondii histone kinase SNF1, putative 0.0022 0.0074 0.0216
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0426 0.1302
Onchocerca volvulus 0.0031 0.0146 0.0814
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.004 0.0122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0034 0.0034
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0113 0.0336
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0 0.0001
Echinococcus multilocularis lamin 0.0026 0.0108 0.0331
Mycobacterium ulcerans transcriptional regulator 0.0031 0.0146 0.0434
Brugia malayi Muscle positioning protein 4 0.0021 0.0061 0.0185
Brugia malayi TAR-binding protein 0.0062 0.0399 0.122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0 0.0001
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0426 0.1292
Echinococcus multilocularis g protein coupled receptor 0.0013 0 0.0001
Trypanosoma cruzi chloride channel protein, putative 0.0031 0.0146 0.0434
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Schistosoma mansoni septate junction protein 0.0021 0.0061 0.0061
Brugia malayi hypoxia-induced factor 1 0.0147 0.1095 0.3352
Loa Loa (eye worm) TK protein kinase 0.0029 0.0134 0.0409
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0116 0.084 0.2571
Toxoplasma gondii brix domain-containing protein 0.0061 0.0389 0.1179
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0176 0.0526
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Onchocerca volvulus Peroxidasin homolog 0.0063 0.0413 0.2311
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0046 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Onchocerca volvulus 0.0014 0.0004 0.002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0019 0.0057
Echinococcus multilocularis lamin dm0 0.0026 0.0108 0.0331
Brugia malayi hypothetical protein 0.0013 0 0.0001
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0054 0.0165
Leishmania major chloride channel protein, putative 0.0031 0.0146 0.0434
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0 0.0001
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0046 0.014
Echinococcus multilocularis protein jagged 2 0.0021 0.0061 0.0185
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0906 0.2772
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0114 0.0823 0.2508
Echinococcus granulosus neural cadherin 0.0021 0.0061 0.0185
Brugia malayi Serotonin receptor 0.0013 0 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0019 0.0019
Brugia malayi hypothetical protein 0.0013 0 0.0001
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0022 0.0074 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0113 0.0615
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0008 0.0024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0031 0.0146 0.0434
Echinococcus granulosus GPCR family 2 0.0016 0.002 0.006
Giardia lamblia Kinase, CAMK CAMKL 0.0022 0.0074 0.0148
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.0264 0.3442
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0031 0.0146 0.0445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Chlamydia trachomatis pyruvate kinase 0.0065 0.0426 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0426 0.1302
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0032 0.0096
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0318
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0034 0.0034
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0 0.0001
Onchocerca volvulus Peroxidase homolog 0.0063 0.0413 0.2311
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Giardia lamblia Pyruvate kinase 0.0033 0.0166 0.1133
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0046
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0031 0.0146 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.013 0.0957 0.292
Onchocerca volvulus 0.0026 0.0108 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Echinococcus granulosus hypothetical protein 0.0013 0 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0 0.0001
Brugia malayi hypothetical protein 0.0159 0.1196 0.3661
Echinococcus granulosus protein jagged 2 0.0021 0.0061 0.0185
Onchocerca volvulus 0.0018 0.004 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0074 0.0074
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0042 0.0233 0.0713
Echinococcus granulosus delta-like protein 1 0.0021 0.0061 0.0185
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.0413 0.2311
Echinococcus granulosus serotonin receptor 0.0013 0 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0034 0.0105
Trypanosoma cruzi AMP deaminase, putative 0.0106 0.0761 0.2318
Brugia malayi Pre-SET motif family protein 0.0203 0.1555 0.4759
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0031 0.0146 0.0912
Loa Loa (eye worm) RNA binding protein 0.0062 0.0399 0.1219
Schistosoma mansoni single-minded 0.0047 0.0281 0.0281
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus multilocularis sex peptide receptor 0.0013 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0184 0.0563
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0305 0.2393 0.2393
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0 0.0001
Echinococcus granulosus lamin dm0 0.0026 0.0108 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0034 0.0105
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0381 0.1157
Treponema pallidum hemolysin (tlyC) 0.0031 0.0146 0.5
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0426 0.2383
Loa Loa (eye worm) SRC-1 0.0042 0.0233 0.0712
Echinococcus granulosus notch 0.0021 0.0061 0.0185
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0005 0.0014
Brugia malayi Voltage gated chloride channel family protein 0.0031 0.0146 0.0445
Schistosoma mansoni hypothetical protein 0.0124 0.0906 0.0906
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.0055 0.0344 0.1043
Echinococcus granulosus H:Cl exchange transporter 7 0.0031 0.0146 0.0445
Entamoeba histolytica AMP deaminase, putative 0.0106 0.0761 1
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0055 0.0344 0.1054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0034 0.0105
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.004 0.0122
Brugia malayi Dopamine receptor protein 2 0.0013 0 0.0001
Brugia malayi Variant SH3 domain containing protein 0.0128 0.0938 0.2871
Loa Loa (eye worm) hypothetical protein 0.0046 0.0271 0.083
Schistosoma mansoni peter pan-related 0.0061 0.0389 0.0389
Entamoeba histolytica AMP deaminase, putative 0.0106 0.0761 1
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0034 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0159 0.1196 0.3661
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0061 0.0185
Brugia malayi Cadherin domain containing protein 0.0021 0.0061 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1555 0.4759
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0019 0.0057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0034 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0034 0.0105
Brugia malayi GnHR receptor homolog 0.0013 0 0.0001
Brugia malayi Dopamine receptor protein 1 0.0013 0 0.0001
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0048 0.0147
Echinococcus multilocularis g protein coupled receptor 0.0013 0 0.0001
Echinococcus granulosus fmrfamide receptor 0.0013 0 0.0001
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0106 0.0761 0.2318
Onchocerca volvulus 0.0026 0.0108 0.0604
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0042 0.0233 0.0713
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.0264 0.0808
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0034 0.0105
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0168 0.1272 0.3893
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0271 0.082
Entamoeba histolytica hypothetical protein 0.0035 0.0182 0.2357
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0271 0.082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0271 0.3536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0096
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0046
Schistosoma mansoni chloride channel protein 0.0031 0.0146 0.0146
Brugia malayi PAS domain containing protein 0.0047 0.0281 0.086
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0113 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0034 0.0105
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0048 0.0147
Echinococcus multilocularis GPCR, family 2 0.0016 0.002 0.006
Trypanosoma cruzi peter pan protein, putative 0.0061 0.0389 0.1179
Toxoplasma gondii CBS domain-containing protein 0.0031 0.0146 0.0434
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0131 0.0401
Toxoplasma gondii fructose-bisphospatase II 0.0305 0.2393 0.732
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0046 0.014
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Plasmodium falciparum serine/threonine protein kinase KIN 0.0022 0.0074 0.0234
Echinococcus granulosus neuropeptides capa receptor 0.0013 0 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0034 0.0034
Brugia malayi steroid hormone receptor 0.0017 0.0034 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0479
Brugia malayi CLC chloride channel protein 0.0031 0.0146 0.0445
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.0061 0.0338
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0 0.0001
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Plasmodium falciparum pyruvate kinase 2 0.0033 0.0166 0.0539
Brugia malayi hypothetical protein 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0537
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0019 0.005
Schistosoma mansoni peroxidasin 0.0063 0.0413 0.0413
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0131 0.0131
Plasmodium vivax adenosine/AMP deaminase, putative 0.0106 0.0761 0.2513
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0199 0.1525 0.466
Brugia malayi hypothetical protein 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0034 0.0105
Echinococcus granulosus pyruvate kinase 0.0065 0.0426 0.1302
Loa Loa (eye worm) hypothetical protein 0.0046 0.0271 0.083
Loa Loa (eye worm) hypothetical protein 0.0049 0.0294 0.0899
Toxoplasma gondii fructose-bisphospatase I 0.0114 0.0823 0.2508
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0412 0.3268 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0131
Giardia lamblia Peter pan protein 0.0061 0.0389 0.3524
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0176 0.1074
Echinococcus multilocularis expressed protein 0.0364 0.2875 0.8796
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0479
Loa Loa (eye worm) oxidoreductase 0.0014 0.0004 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0019 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Onchocerca volvulus 0.0021 0.0061 0.0338
Echinococcus granulosus H:Cl exchange transporter 3 0.0031 0.0146 0.0445
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0426 0.2383
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0034 0.0105
Echinococcus granulosus H:Cl exchange transporter 4 0.0031 0.0146 0.0445
Trypanosoma cruzi hypothetical protein 0.013 0.0957 0.292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0046 0.014
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0005 0.0015
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0 0.0001
Echinococcus granulosus pyruvate kinase 0.0033 0.0166 0.0508
Trypanosoma cruzi chloride channel protein, putative 0.0031 0.0146 0.0434
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0061 0.0185
Treponema pallidum Mg2+ transport protein (mgtE) 0.0031 0.0146 0.5
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0061 0.0185
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0031 0.0146 0.0912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0061 0.0061
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0 0.0001
Onchocerca volvulus 0.0063 0.0413 0.2311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0537
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0271 0.082
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0399 0.0399
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0131 0.0401
Echinococcus granulosus g protein coupled receptor 0.0013 0 0.0001
Onchocerca volvulus Peroxidasin homolog 0.0063 0.0413 0.2311
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0 0.0001
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Mycobacterium tuberculosis Conserved protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0445
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0034 0.0105
Brugia malayi putative serine/threonine kinase SADA gamma 0.0022 0.0074 0.0228
Schistosoma mansoni hypothetical protein 0.0035 0.0182 0.0182
Echinococcus granulosus intermediate filament protein 0.0026 0.0108 0.0331
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0004 0.0012
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0113 0.0336
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0034 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0108 0.033
Plasmodium falciparum pyruvate kinase 0.0065 0.0426 0.1401
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0381 0.1157
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0426 0.1292
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0034 0.0034
Plasmodium vivax phospholipase C-like, putative 0.0017 0.0032 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0034 0.0105
Loa Loa (eye worm) GMP reductase 0.0168 0.1272 0.3892
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.022
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0035 0.0182 0.2357
Loa Loa (eye worm) hypothetical protein 0.0046 0.0271 0.083
Trypanosoma cruzi AMP deaminase, putative 0.0106 0.0761 0.2318
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Giardia lamblia Pyruvate kinase 0.0065 0.0426 0.3919
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0413 0.1263
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0074 0.0074
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0113 0.1448
Brugia malayi RE15519p 0.0013 0 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.014
Echinococcus granulosus AMP deaminase 2 0.0106 0.0761 0.2327
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0034 0.0105
Entamoeba histolytica serine/threonine protein kinase, putative 0.0022 0.0074 0.0933
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Onchocerca volvulus 0.0017 0.0034 0.0192
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0167 0.0511
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0061 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0034 0.0105
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.006
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0046 0.014
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0113 0.0347
Echinococcus multilocularis pyruvate kinase 0.0033 0.0166 0.0508
Echinococcus granulosus neuropeptide s receptor 0.0013 0 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0008 0.0024
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0399 0.122
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0426 0.1292
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0233 0.0713
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0381 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0034 0.0105
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0019 0.0057
Brugia malayi hypothetical protein 0.0013 0 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0034 0.0105
Schistosoma mansoni chloride channel protein 0.0031 0.0146 0.0146
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0412 0.3268 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0 0.0001
Brugia malayi Pre-SET motif family protein 0.0029 0.0131 0.0401
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0012
Onchocerca volvulus 0.0014 0.0004 0.002
Onchocerca volvulus 0.0014 0.0004 0.002
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0554
Plasmodium falciparum AMP deaminase, putative 0.0106 0.0761 0.2513
Leishmania major CBS domain protein, conserved 0.0031 0.0146 0.0434
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0061 0.0185
Brugia malayi protein-tyrosine kinase 0.0036 0.0184 0.0563
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0168 0.1272 0.3893
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0106 0.0761 0.2318
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0305 0.2393 0.732
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0061 0.0174
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0412 0.3268 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0182 0.0182
Echinococcus multilocularis fibropellin Ia 0.0021 0.0061 0.0185
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0057
Brugia malayi RNA binding protein 0.0062 0.0399 0.122
Brugia malayi hypothetical protein 0.0019 0.0046 0.014
Echinococcus multilocularis protein jagged 1 0.0021 0.0061 0.0185
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0399 0.1219
Echinococcus multilocularis fmrfamide receptor 0.0013 0 0.0001
Echinococcus granulosus slit 2 protein 0.0021 0.0061 0.0185
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0413 0.1262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Echinococcus multilocularis musashi 0.0026 0.0108 0.0331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0271 0.082
Echinococcus granulosus fibropellin Ia 0.0021 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0537
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0017 0.0032 0.0092
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0034 0.0105
Brugia malayi hypothetical protein 0.0013 0 0.0001
Echinococcus multilocularis pyruvate kinase 0.0033 0.0166 0.0508
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0046 0.0235
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Brugia malayi G-protein coupled receptor 0.0013 0 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0034 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0034 0.0105
Echinococcus granulosus AMPK beta subunit 0.0055 0.0344 0.1054
Brugia malayi Blistered cuticle protein 3 0.0063 0.0413 0.1263
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0121
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.004 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Brugia malayi hypothetical protein 0.0022 0.0072 0.022
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0176 0.0537
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Onchocerca volvulus Putative cubilin 0.0021 0.0061 0.0338
Leishmania major hypothetical protein, conserved 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0445
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Brugia malayi putative neuropeptide receptor 0.0013 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0042 0.0233 0.0713
Plasmodium vivax pyruvate kinase 2, putative 0.0033 0.0166 0.0539
Echinococcus multilocularis slit 2 protein 0.0021 0.0061 0.0185
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0294 0.0899
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0537
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Trypanosoma brucei AMP deaminase, putative 0.0106 0.0761 0.2318
Brugia malayi ancient conserved domain protein 4 0.0031 0.0146 0.0445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Schistosoma mansoni hypothetical protein 0.0027 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0034 0.0105
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0479
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0184 0.0563
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0122 0.0374
Echinococcus granulosus lamin 0.0026 0.0108 0.0331
Echinococcus granulosus neuropeptide Y receptor 0.0013 0 0.0001
Schistosoma mansoni protein kinase subunit beta 0.003 0.0135 0.0135
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0022 0.0074 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0034 0.0105
Schistosoma mansoni cell polarity protein 0.0021 0.0061 0.0061
Brugia malayi isocitrate dehydrogenase 0.0015 0.0019 0.0057
Loa Loa (eye worm) loechrig isoform VII 0.0134 0.0992 0.3035
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Echinococcus multilocularis AMPK beta subunit 0.0055 0.0344 0.1054
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0031 0.0146 0.0445
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0271 0.3536
Schistosoma mansoni hypothetical protein 0.0165 0.1246 0.1246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0034 0.0105
Mycobacterium tuberculosis Conserved protein 0.0031 0.0146 0.0434
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0113 0.0336
Onchocerca volvulus 0.0018 0.004 0.0222
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0 0.0001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0294 0.0899
Loa Loa (eye worm) chloride channel protein 7 0.0031 0.0146 0.0445
Loa Loa (eye worm) hypothetical protein 0.0029 0.0131 0.0401
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0176 0.0571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.014
Giardia lamblia Hypothetical protein 0.0031 0.0146 0.0912
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0034 0.0105
Brugia malayi fructose-1,6-bisphosphatase 0.0305 0.2393 0.7323
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.014
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0413 0.1263
Entamoeba histolytica hypothetical protein 0.0035 0.0182 0.2357
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0046 0.014
Echinococcus granulosus protein jagged 1 0.0021 0.0061 0.0185
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0906 0.2772
Leishmania major chloride channel protein, putative 0.0031 0.0146 0.0434
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0031 0.0146 0.0445
Brugia malayi SRC-1 0.0042 0.0233 0.0713
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0412 0.3268 0.3268
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0061 0.0338
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0554
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0004 0.0012
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0134 0.0992 0.3035
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0031 0.0146 0.0434
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0426 0.1292
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0046
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.018 0.0551
Schistosoma mansoni pyruvate kinase 0.0065 0.0426 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0012
Echinococcus granulosus tyrosine protein kinase Lyn 0.0042 0.0235 0.072
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0061 0.0185
Echinococcus granulosus g protein coupled receptor 0.0013 0 0.0001
Echinococcus granulosus zinc finger protein 598 0.006 0.0386 0.118
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0412 0.3268 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0019 0.0046
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0426 0.2368
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0184 0.0563
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0176 0.0526
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0 0.0001
Onchocerca volvulus Peroxidase homolog 0.0063 0.0413 0.2311
Echinococcus multilocularis neural cadherin 0.0021 0.0061 0.0185
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0031 0.0146 0.0146
Onchocerca volvulus 0.0021 0.0061 0.0338
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0034 0.0105
Trypanosoma brucei GMP reductase 0.0412 0.3268 1
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Brugia malayi ecdysteroid receptor 0.0017 0.0034 0.0105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0 0.0001
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0046 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0399 0.0399
Echinococcus multilocularis peroxidasin 0.0063 0.0413 0.1263
Brugia malayi hypothetical protein 0.0035 0.0182 0.0557
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0381 0.0381
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0034 0.0105
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Leishmania major hypothetical protein, conserved 0.0055 0.0344 0.1043
Echinococcus multilocularis pyruvate kinase 0.0033 0.0166 0.0508
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.014
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0271 0.083
Schistosoma mansoni tyrosine kinase 0.0042 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0106 0.0761 0.2327
Giardia lamblia Kinase, CAMK CAMKL 0.0022 0.0074 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0034 0.0105
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0046
Echinococcus multilocularis serotonin receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0271 0.082
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0061 0.0185
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0034 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1785 1
Echinococcus granulosus neuropeptide receptor 0.0013 0 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0034 0.0105
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0033 0.0159 0.0476
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0 0.0001
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0055 0.0344 0.1054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0034 0.0105
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0271 0.082
Brugia malayi hypothetical protein 0.0063 0.0413 0.1263
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0042 0.0233 0.0713
Schistosoma mansoni intermediate filament proteins 0.0026 0.0108 0.0108
Brugia malayi sulfakinin receptor protein 0.0013 0 0.0001
Echinococcus granulosus G protein coupled receptor 139 0.0013 0 0.0001
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0381 0.3015 0.9225
Onchocerca volvulus 0.0021 0.0061 0.0338
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0 0.0001
Schistosoma mansoni peroxidasin 0.0063 0.0413 0.0413
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0 0.0001
Brugia malayi G-protein coupled receptor 0.0013 0 0.0001
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0106 0.0761 0.2318
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0031 0.0146 0.0434
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Brugia malayi AKH receptor 0.0013 0 0.0001
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.0055 0.0344 0.1043
Brugia malayi Melatonin receptor type 1A 0.0013 0 0.0001
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0022 0.0074 0.0216
Echinococcus granulosus tyrosine protein kinase Src64B 0.0042 0.0233 0.0713
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0131 0.039
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0389 0.1279
Mycobacterium tuberculosis Conserved protein 0.0031 0.0146 0.0434
Echinococcus granulosus orexin receptor type 2 0.0013 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0042 0.0233 0.0713
Trypanosoma cruzi AMP deaminase, putative 0.0106 0.0761 0.2318
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0426 0.2368
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.014
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0012
Leishmania major phospholipase c-like protein 0.0018 0.004 0.0111
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0061 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0139
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0046
Leishmania major guanosine monophosphate reductase 0.0412 0.3268 1
Echinococcus multilocularis protein jagged 1 0.0021 0.0061 0.0185
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0426 0.2383
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0381 0.1167
Echinococcus multilocularis g-protein coupled receptor 0.0013 0 0.0001
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0004 0.0004
Brugia malayi hypothetical protein 0.0013 0 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0057
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0074 0.0074
Brugia malayi ORL1-like opioid receptor 0.0013 0 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0 0.0001
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0305 0.2393 0.732
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0 0.0001
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.004 0.0121
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.003 0.0135 0.0413
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0413 0.1263
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Schistosoma mansoni protein kinase subunit beta 0.0055 0.0344 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0042 0.0233 0.0713
Schistosoma mansoni notch 0.0021 0.0061 0.0061
Schistosoma mansoni pyruvate kinase 0.0033 0.0166 0.0166
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0412 0.3268 1
Echinococcus granulosus serine:threonine kinase SAD 1 0.0022 0.0074 0.0228
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0412 0.3268 1
Echinococcus granulosus neuropeptide receptor A26 0.0013 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0381 0.1157
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0061 0.0185
Brugia malayi follicle stimulating hormone receptor 0.0013 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0271 0.083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0034 0.0034
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0426 0.1292
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0 0.0001
Echinococcus granulosus pyruvate kinase 0.0033 0.0166 0.0508
Echinococcus granulosus pyruvate kinase 0.0065 0.0426 0.1302
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0294 0.0899
Brugia malayi ancient conserved domain protein 2 0.0031 0.0146 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.014
Brugia malayi EGF-like domain containing protein 0.0021 0.0061 0.0185
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0271 0.082
Echinococcus multilocularis zinc finger protein 598 0.006 0.0386 0.118
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0381 0.1167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0413 0.1262
Loa Loa (eye worm) AMP deaminase 0.0106 0.0761 0.2327
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0 0.0001
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0061 0.0185
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Toxoplasma gondii AMP deaminase 0.0106 0.0761 0.2318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0131
Leishmania major 0.0305 0.2393 0.732
Trypanosoma cruzi GMP reductase 0.0412 0.3268 1
Trichomonas vaginalis CAMK family protein kinase 0.0022 0.0074 0.0396
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0426 0.1292
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.004 0.0111
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0426 0.1302
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0046
Trichomonas vaginalis ssf, putative 0.0061 0.0389 0.2161
Mycobacterium ulcerans hypothetical protein 0.0031 0.0146 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0034 0.0105
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0031 0.0146 0.0434
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0271 0.082
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0957 0.535
Trypanosoma brucei SNF1-related protein kinases, putative 0.0022 0.0074 0.0216
Echinococcus granulosus tyrosine protein kinase Src42A 0.0042 0.0233 0.0713
Toxoplasma gondii pyruvate kinase PyKII 0.0033 0.0166 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0 0.0001
Onchocerca volvulus 0.0046 0.0271 0.152
Onchocerca volvulus 0.0021 0.0061 0.0338
Mycobacterium ulcerans hypothetical protein 0.0046 0.0271 0.082
Trypanosoma cruzi peter pan protein, putative 0.0061 0.0389 0.1179
Brugia malayi CBS domain containing protein 0.0031 0.0146 0.0445
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0034 0.0105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0185
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0061 0.0185
Loa Loa (eye worm) chloride channel 3 0.0031 0.0146 0.0445
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0426 0.1292
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0019 0.0046
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0013 0 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0108 0.033
Brugia malayi GMP reductase 0.0168 0.1272 0.3893
Trypanosoma cruzi AMP deaminase, putative 0.0106 0.0761 0.2318
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.013 0.0957 0.292
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0554
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0048 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0034 0.0105
Onchocerca volvulus AMP deaminase 2 homolog 0.0106 0.0761 0.426
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0134 0.0992 0.3035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0399 0.0399
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0213 0.1636 0.4999
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0271 0.082
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0 0.0001

Activities

Activity type Activity value Assay description Source Reference
Cr secretion (functional) = 0.4 % Percentage of [51Cr]- secreted in feces was determined by fecal drug-induced bleeding method in rat at 100 mg/kg, bid for 5 days ChEMBL. 12877584
EC50 (functional) = 24 uM Vasodilation of phenylephrine-induced contraction in Wistar rat aorta in the presence of ODQ ChEMBL. 17335184
IC50 (binding) = 156 nM In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determined ChEMBL. 12877584
IC50 (binding) = 156 nM In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determined ChEMBL. 12877584
IC50 (binding) = 0.004 uM In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cells ChEMBL. 12877584
IC50 (binding) = 0.004 uM In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cells ChEMBL. 12877584
IC50 (binding) = 0.09 uM Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs ChEMBL. 17335184
IC50 (binding) = 0.09 uM Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs ChEMBL. 17335184
IC50 (binding) = 5.8 uM Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hr ChEMBL. 17335184
IC50 (binding) = 5.8 uM Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hr ChEMBL. 17335184
IC50 (binding) > 10 uM In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells ChEMBL. 12877584
IC50 (binding) > 10 uM In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells ChEMBL. 12877584
Inhibition (functional) = 24.2 % In vivo anti-inflammatory activity determined by rat carrageenan paw edema method at 10 mg/kg perorally ChEMBL. 12877584
Inhibition (binding) = 79 % In vitro percent inhibition of prostaglandin G/H synthase 2 (COX-2) in human whole blood at 1 microM ChEMBL. 12877584
Inhibition (binding) = 79 % In vitro percent inhibition of prostaglandin G/H synthase 2 (COX-2) in human whole blood at 1 microM ChEMBL. 12877584
Inhibition (functional) = 80 % In vivo analgesic activity of compound was determined by inflammatory hyperalgesia model at 3 mg/kg perorally in rat ChEMBL. 12877584
Inhibition (functional) = 86 % In vivo inhibition of contralateral paw swelling after oral treatment for 28 days (1 mg/kg od) was determined by adjuvabt arthritis in rat ChEMBL. 12877584
Inhibition (functional) = 89.5 % In vivo anti-inflammatory activity by air pouch model at 1 mg/kg perorally in rat. ChEMBL. 12877584
Inhibition (binding) = 100 % Inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood at 10 microM ChEMBL. 12877584
Inhibition (binding) = 100 % Inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood at 10 microM ChEMBL. 12877584
T1/2 (ADMET) = 2.2 hr Half life of compound was determined at 1 mg/kg intravenous administration in rat ChEMBL. 12877584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.