Detailed information for compound 2069725

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.407 | Formula: C18H22N6O
  • H donors: 0 H acceptors: 3 LogP: 1.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCN(C(C1)C)c1ccc2n(n1)cnn2
  • InChi: 1S/C18H22N6O/c1-14-11-22(12-15-4-3-5-16(10-15)25-2)8-9-23(14)18-7-6-17-20-19-13-24(17)21-18/h3-7,10,13-14H,8-9,11-12H2,1-2H3
  • InChiKey: MUQYUPNCHKPXPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0222 0.2622 0.2622
Brugia malayi Cytochrome P450 family protein 0.0056 0.0479 0.0693
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Onchocerca volvulus 0.009 0.0915 0.3154
Echinococcus granulosus lamin 0.009 0.0915 0.0915
Mycobacterium leprae putative cytochrome p450 0.0027 0.0109 0.0947
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0206 0.2413 0.2413
Brugia malayi EGF-like domain containing protein 0.0025 0.0075 0.0109
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0312 0.651
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0479 1
Loa Loa (eye worm) nuclear hormone receptor 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0178 0.205 0.2964
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0232
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0109 0.0284
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0473 0.0684
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0013 0.0013
Brugia malayi steroid hormone receptor 0.0222 0.2622 0.3791
Brugia malayi nuclear hormone receptor 0.0105 0.1109 0.1603
Brugia malayi intermediate filament protein 0.009 0.0915 0.1322
Onchocerca volvulus 0.0043 0.0312 0.1076
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0004 0.0117
Echinococcus granulosus intermediate filament protein 0.009 0.0915 0.0915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0222 0.2622 0.3791
Entamoeba histolytica Ran family GTPase 0.0019 0.0004 0.0017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0105 0.1109 0.3825
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0141 0.0204
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0075 0.0075
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1009 0.8784
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0105 0.1109 0.1109
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0109 0.0284
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0043 0.0312 0.0812
Leishmania major DNA polymerase kappa, putative 0.002 0.0013 0.0203
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0323 0.3927 0.3927
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0262
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0246 0.5144
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0109 0.0947
Brugia malayi nuclear receptor RXR 0.0105 0.1109 0.1603
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.5897 0.5897
Echinococcus multilocularis cpg binding protein 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0266 0.0385
Schistosoma mansoni cpg binding protein 0.0031 0.0163 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0222 0.2622 0.2622
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0246 0.0642
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0222 0.2622 0.2622
Brugia malayi hypothetical protein 0.0272 0.3267 0.4723
Loa Loa (eye worm) hypothetical protein 0.0272 0.3267 0.4723
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0109 0.0947
Brugia malayi Cytochrome P450 family protein 0.0112 0.1198 0.1732
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0025 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1009 0.8784
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0109 0.0947
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0109 0.0109
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0109 0.176
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0043 0.0312 0.651
Loa Loa (eye worm) hypothetical protein 0.0555 0.6917 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0109 0.0284
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0479 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0222 0.2622 0.3791
Entamoeba histolytica hypothetical protein 0.0182 0.2105 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0222 0.2622 0.3791
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0105 0.1109 0.1109
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0006 0.5
Echinococcus granulosus lamin dm0 0.009 0.0915 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0222 0.2622 0.3791
Plasmodium vivax glutathione reductase, putative 0.0043 0.0306 1
Trypanosoma brucei unspecified product 0.002 0.0013 0.0262
Loa Loa (eye worm) intermediate filament protein 0.009 0.0915 0.1322
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0222 0.2622 0.2622
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0618 0.0618
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0222 0.2622 0.2622
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0306 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0105 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0117 0.1271 0.1837
Brugia malayi hypothetical protein 0.0144 0.1608 0.2325
Echinococcus multilocularis lamin 0.009 0.0915 0.0915
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0109 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0312 0.0812
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0246 0.0246
Echinococcus granulosus Nuclear hormone receptor HR96 0.0105 0.1109 0.1109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0222 0.2622 0.2622
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0222 0.2622 0.2622
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0134 0.0134
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.2105 0.2105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0134 0.0134
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0246 0.0246
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0029 0.0134 0.279
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0312 0.651
Brugia malayi hypothetical protein 0.0117 0.1271 0.1837
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0109 0.0284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0222 0.2622 0.3791
Brugia malayi bZIP transcription factor family protein 0.0183 0.2115 0.3057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0246 0.5144
Brugia malayi Nuclear hormone receptor-like 1 0.0222 0.2622 0.3791
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0571 0.0571
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0109 0.0947
Echinococcus multilocularis 0.0027 0.0109 0.0109
Trichomonas vaginalis guanylate cyclase, putative 0.0043 0.0312 0.0812
Echinococcus granulosus single minded 2 0.0123 0.1337 0.1337
Echinococcus granulosus FTZ F1 alpha 0.0222 0.2622 0.2622
Echinococcus multilocularis dna polymerase kappa 0.002 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0222 0.2622 0.3791
Echinococcus granulosus nuclear receptor nhr 48 0.0105 0.1109 0.1109
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0029 0.0134 0.279
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.1271 0.1271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.2105 0.2105
Trypanosoma brucei trypanothione reductase 0.0043 0.0306 0.639
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0092 0.1487
Brugia malayi hypothetical protein 0.0117 0.1271 0.1837
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0246 0.1171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0161 0.0161
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0105 0.1109 0.1603
Schistosoma mansoni cpg binding protein 0.0031 0.0163 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.0262
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0043 0.0312 0.651
Echinococcus granulosus pikachurin 0.0025 0.0075 0.0075
Trichomonas vaginalis ran, putative 0.0019 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0117 0.1271 0.1837
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0222 0.2622 0.3791
Onchocerca volvulus 0.0244 0.2899 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0182 0.2105 1
Schistosoma mansoni nuclear hormone receptor 0.0105 0.1109 0.1109
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0004 0.0075
Onchocerca volvulus 0.0031 0.0161 0.0554
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0109 0.0947
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0006 0.0244
Echinococcus multilocularis snurportin 1 0.0277 0.333 0.333
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0029 0.0134 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0618 0.1611
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1009 0.8784
Brugia malayi orphan nuclear receptor NR2E1 0.0105 0.1109 0.1603
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0029 0.0075
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0043 0.0312 0.5042
Brugia malayi nuclear receptor RXR 0.0117 0.1271 0.1837
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0004 0.0004
Schistosoma mansoni survival motor neuron protein 0.0056 0.0473 0.0473
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1009 0.8784
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0502 0.0725
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0109 0.0947
Onchocerca volvulus 0.003 0.0141 0.0487
Schistosoma mansoni hypothetical protein 0.035 0.4264 0.4264
Echinococcus multilocularis FTZ F1 alpha 0.0222 0.2622 0.2622
Schistosoma mansoni coup transcription factor 0.0222 0.2622 0.2622
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0013 0.0033
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0043 0.0312 0.651
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0222 0.2622 0.2622
Schistosoma mansoni cytochrome P450 0.0027 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0222 0.2622 0.3791
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0006 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0109 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0161
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0109 0.0284
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0618 0.0618
Brugia malayi Cytochrome P450 family protein 0.0027 0.0109 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0222 0.2622 0.3791
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0109 0.0947
Loa Loa (eye worm) steroid hormone receptor 0.0222 0.2622 0.3791
Loa Loa (eye worm) isocitrate dehydrogenase 0.0029 0.0134 0.0193
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Schistosoma mansoni DNA polymerase eta 0.002 0.0013 0.0013
Plasmodium vivax importin-beta 2, putative 0.0026 0.0092 0.3004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0006 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0006 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0618 0.1611
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0109 0.0947
Schistosoma mansoni cell polarity protein 0.0025 0.0075 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0222 0.2622 0.3791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0362 0.0362
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0306 0.0306
Onchocerca volvulus 0.009 0.0915 0.3154
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0183 0.2115 0.2115
Brugia malayi nuclear receptor NHR-88 0.0105 0.1109 0.1603
Schistosoma mansoni hypothetical protein 0.0149 0.1673 0.1673
Schistosoma mansoni hypothetical protein 0.0056 0.0473 0.0473
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0266 0.0385
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.2105 0.2105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0013
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0197
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.1149 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0183 0.2115 0.2115
Schistosoma mansoni ran 0.0019 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0424 0.5224 0.5224
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.0262
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0092 0.0092
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0262
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0006 0.0016
Brugia malayi RNA, U transporter 1 0.0074 0.0709 0.1025
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0013 0.0262
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0109 0.0947
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0479 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0109 0.0947
Echinococcus granulosus Nuclear hormone receptor HR96 0.0105 0.1109 0.1109
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0246 0.0246
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0013 0.0109
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1009 0.8784
Leishmania major GTP-binding protein, putative 0.0019 0.0004 0.0058
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0043 0.0312 0.0451
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0029 0.0134 0.0134
Leishmania major cytochrome p450-like protein 0.0027 0.0109 0.176
Onchocerca volvulus Protein ultraspiracle homolog 0.0222 0.2622 0.9046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0362 0.0362
Echinococcus multilocularis pikachurin 0.0025 0.0075 0.0075
Echinococcus granulosus cpg binding protein 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0377 0.0545
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0029 0.0075
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0516 0.0746
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0109 0.0947
Echinococcus multilocularis musashi 0.009 0.0915 0.0915
Brugia malayi Nuclear hormone receptor E75 0.0105 0.1109 0.1603
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0109 0.0947
Brugia malayi hypoxia-induced factor 1 0.0512 0.6362 0.9198
Plasmodium falciparum glutathione reductase 0.0043 0.0306 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0109 0.0284
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Leishmania major importin beta-1 subunit, putative 0.0021 0.0029 0.0463
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.0426
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0109 0.0284
Echinococcus multilocularis aryl hydrocarbon receptor 0.0043 0.0312 0.0312
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0222 0.2622 0.2622
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0029 0.0134 0.0134
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0222 0.2622 0.2622
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0117 0.1271 0.1271
Brugia malayi nuclear hormone receptor 0.0222 0.2622 0.3791
Schistosoma mansoni microtubule-associated protein tau 0.0795 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0105 0.1109 0.1603
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0109 0.0947
Schistosoma mansoni nuclear hormone receptor 0.0222 0.2622 0.2622
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0029 0.0075
Echinococcus granulosus neuropeptide s receptor 0.0476 0.5897 0.5897
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0134 0.0134
Trichomonas vaginalis adenylate cyclase, putative 0.0043 0.0312 0.0812
Schistosoma mansoni hypothetical protein 0.0182 0.2105 0.2105
Schistosoma mansoni thyroid hormone receptor 0.0222 0.2622 0.2622
Loa Loa (eye worm) cytochrome P450 0.0027 0.0109 0.0157
Schistosoma mansoni zinc finger protein 0.0105 0.1109 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0246 0.0642
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0109 0.0284
Loa Loa (eye worm) hypothetical protein 0.0117 0.1271 0.1837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.1109 0.1109
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0029 0.0134 0.4366
Echinococcus granulosus dna polymerase kappa 0.002 0.0013 0.0013
Loa Loa (eye worm) hypoxia-induced factor 1 0.0512 0.6362 0.9198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0161
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0222 0.2622 0.9046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0306 0.2664
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0362 0.0524
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0013 0.0262
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1009 0.8784
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0571 0.9231
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.5224 0.5224
Schistosoma mansoni nuclear receptor 0.0105 0.1109 0.1109
Echinococcus multilocularis dna polymerase eta 0.002 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0214 0.2519 0.3641
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0109 0.0284
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.3267 0.3267
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0161 0.2595
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.0141
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0109 0.0284
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.5897 0.5897
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0013 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2899 0.7553
Brugia malayi Thioredoxin reductase 0.0043 0.0306 0.0443
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2519 0.3641
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0246 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0161 0.0161
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0004 0.0117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0013 0.0203
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0316 0.0316
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0246 0.0246
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.0134 0.2161
Brugia malayi Nuclear hormone receptor E75 0.0105 0.1109 0.1603
Echinococcus granulosus slit 2 protein 0.0025 0.0075 0.0075
Brugia malayi glutathione reductase 0.0043 0.0306 0.0443
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0109 0.2272
Onchocerca volvulus 0.0105 0.1109 0.3825
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0013
Loa Loa (eye worm) DR-78 0.0105 0.1109 0.1603
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0479 0.0693
Echinococcus granulosus geminin 0.035 0.4264 0.4264
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0184
Echinococcus multilocularis microtubule associated protein 2 0.0795 1 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0109 0.0284
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0105 0.1109 0.3825
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0109 0.0947
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.0262
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.1271 0.1837
Giardia lamblia DINP protein human, muc B family 0.002 0.0013 0.0508
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0499 0.8067
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0109 0.2272
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0029 0.0598
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0109 0.2272
Echinococcus multilocularis lamin dm0 0.009 0.0915 0.0915
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0246 0.5144
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0043 0.0312 0.0812
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0915 0.1322
Echinococcus multilocularis jun protein 0.0183 0.2115 0.2115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0222 0.2622 0.3791
Onchocerca volvulus Bile acid receptor homolog 0.0222 0.2622 0.9046
Echinococcus multilocularis geminin 0.035 0.4264 0.4264
Schistosoma mansoni lamin 0.009 0.0915 0.0915
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0246 0.0246
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0109 0.0284
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0222 0.2622 0.2622
Echinococcus granulosus jun protein 0.0183 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.0426
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0571 0.4969
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0618 0.0618
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0109 0.0947
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0306 0.0306
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0109 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0222 0.2622 0.3791
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0222 0.2622 0.2622
Brugia malayi hypothetical protein 0.0182 0.2105 0.3043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0222 0.2622 0.2622
Brugia malayi isocitrate dehydrogenase 0.0029 0.0134 0.0193
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0571 0.0571
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0075 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0222 0.2622 0.2622
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0277 0.333 0.4815
Loa Loa (eye worm) glutathione reductase 0.0043 0.0306 0.0443
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0105 0.1109 0.1109
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0109 0.0284
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0013 0.0109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0502 0.0725
Brugia malayi follicle stimulating hormone receptor 0.0257 0.3074 0.4444
Loa Loa (eye worm) hypothetical protein 0.0043 0.0316 0.0456
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0029 0.0134 0.4366
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.0134 0.2161
Brugia malayi Pre-SET motif family protein 0.0031 0.0161 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0222 0.2622 0.3791
Loa Loa (eye worm) hypothetical protein 0.0117 0.1271 0.1837
Echinococcus granulosus aryl hydrocarbon receptor 0.0043 0.0312 0.0312
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0109 0.176
Onchocerca volvulus 0.0144 0.1608 0.5548
Schistosoma mansoni jun-related protein 0.0149 0.1673 0.1673
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0004 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0006 0.0126
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0222 0.2622 0.2622
Brugia malayi CXXC zinc finger family protein 0.003 0.0141 0.0204
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0109 0.0284
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0025 0.0075 0.0109
Loa Loa (eye worm) hypothetical protein 0.0043 0.0312 0.0451
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.1198 0.1732
Toxoplasma gondii thioredoxin reductase 0.0043 0.0306 0.4949
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0006 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0222 0.2622 0.2622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0222 0.2622 0.3791
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0109 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0004 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0362 0.0524
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0377 0.0545
Plasmodium falciparum thioredoxin reductase 0.0043 0.0306 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0013 0.0033
Onchocerca volvulus 0.0056 0.0473 0.1632
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0312 0.0812
Schistosoma mansoni ran 0.0019 0.0004 0.0004
Schistosoma mansoni aryl hydrocarbon receptor 0.0166 0.1891 0.1891
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0586 0.0586
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0109
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0043 0.0312 0.0812
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0134 0.279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0571 0.1487
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0117 0.1271 0.1837
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0105 0.1109 0.1109
Trichomonas vaginalis glutaminase, putative 0.0317 0.3839 1
Echinococcus multilocularis slit 2 protein 0.0025 0.0075 0.0075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0004 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0092 0.1919
Brugia malayi ecdysteroid receptor 0.0222 0.2622 0.3791
Echinococcus granulosus ecdysone induced protein 78C 0.0222 0.2622 0.2622
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0043 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0027 0.0109 0.0109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0915 0.1322
Mycobacterium leprae Possible regulatory protein 0.0043 0.0312 0.2714
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0006 0.0029
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0117 0.1271 0.1271
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Schistosoma mansoni glutaminase 0.0317 0.3839 0.3839
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0277 0.333 0.333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0006 0.0126
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0618 0.5383
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0004 0.0058
Brugia malayi photoreceptor-specific nuclear receptor 0.0222 0.2622 0.3791
Onchocerca volvulus 0.0222 0.2622 0.9046
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.1271 0.1837
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0246 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0362 0.0362
Leishmania major DNA polymerase eta, putative 0.002 0.0013 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.1109 0.1109
Echinococcus multilocularis isocitrate dehydrogenase 0.0029 0.0134 0.0134
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0092 0.1919
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0306 0.639
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0618 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.1149 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0222 0.2622 0.2622
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0246 1
Loa Loa (eye worm) glutaminase 0.0317 0.3839 0.555
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0004 0.0075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0006 0.5
Echinococcus multilocularis transfer RNA-Lys 0.0123 0.1337 0.1337
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0006 0.0052
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0029 0.0134 0.1163
Echinococcus granulosus snurportin 1 0.0277 0.333 0.333
Mycobacterium ulcerans putative regulatory protein 0.0123 0.1337 0.3482
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0316 0.0316
Entamoeba histolytica hypothetical protein 0.0021 0.0029 0.0136
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0222 0.2622 0.3791
Echinococcus granulosus dnaJ subfamily B 0.0424 0.5224 0.5224
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0133
Echinococcus granulosus thyroid hormone receptor alpha 0.0105 0.1109 0.1109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0222 0.2622 0.3791
Schistosoma mansoni lamin 0.009 0.0915 0.0915
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0109 0.0947
Plasmodium vivax SET domain protein, putative 0.0031 0.0161 0.5244
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0043 0.0312 0.5
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0109 0.0284
Leishmania major cytochrome p450-like protein 0.0056 0.0479 0.7746
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0109 0.0947
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0109
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0109 0.0284
Leishmania major cytochrome p450-like protein 0.0027 0.0109 0.176
Brugia malayi nuclear hormone receptor family member odr-7 0.0105 0.1109 0.1603
Entamoeba histolytica hypothetical protein 0.0182 0.2105 1
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.3267 0.3267
Brugia malayi PAS domain containing protein 0.0166 0.1891 0.2734
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0013 0.0033
Schistosoma mansoni nuclear receptor 0.0105 0.1109 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0222 0.2622 0.3791
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.009 0.0915 0.1322
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0105 0.1109 0.1109
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0109 0.0947
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0109 0.0284
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0571 0.0571
Leishmania major protein kinase, putative 0.0043 0.0312 0.5042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0362 0.0362
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0197
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0571 0.1487
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0006 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0222 0.2622 0.2622
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0013 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Brugia malayi nuclear receptor NHR-67 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Echinococcus granulosus importin subunit beta 1 0.0026 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.0161
Brugia malayi hypothetical protein 0.0105 0.1109 0.1603
Brugia malayi ecdysone receptor 0.0105 0.1109 0.1603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0222 0.2622 0.3791
Brugia malayi conserved hypotetical protein 0.0105 0.1109 0.1603
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.3074 0.4444
Schistosoma mansoni hypothetical protein 0.035 0.4264 0.4264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0222 0.2622 0.3791
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0222 0.2622 0.3791
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0502 0.0725
Brugia malayi nuclear receptor NHR-88 0.0222 0.2622 0.3791
Brugia malayi hypothetical protein 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0161 0.0161
Brugia malayi Steroid receptor seven-up type 2 0.0222 0.2622 0.3791
Loa Loa (eye worm) CYP4Cod1 0.0056 0.0479 0.0693
Brugia malayi Cytochrome P450 family protein 0.0056 0.0479 0.0693
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0109
Brugia malayi laminin alpha chain 0.0025 0.0075 0.0109
Loa Loa (eye worm) hypothetical protein 0.0117 0.1271 0.1837
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0262
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Brugia malayi hypothetical protein 0.0555 0.6917 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.1149 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0109 0.2272
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0306 0.0443
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0134 0.2161
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Schistosoma mansoni slit 0.0025 0.0075 0.0075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0004 0.0075
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Leishmania major protein kinase, putative 0.0043 0.0312 0.5042
Plasmodium falciparum importin beta, putative 0.0026 0.0092 0.3004
Onchocerca volvulus 0.0123 0.1337 0.4611
Schistosoma mansoni single-minded 0.0166 0.1891 0.1891
Mycobacterium tuberculosis Probable reductase 0.0097 0.1009 0.8784
Trypanosoma brucei cytochrome P450, putative 0.0056 0.0479 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0222 0.2622 0.2622
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0006 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0138 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0109 0.0947
Brugia malayi bHLH-PAS transcription factor 0.0123 0.1337 0.1933
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Brugia malayi glutaminase DH11.1 0.0317 0.3839 0.555
Schistosoma mansoni intermediate filament proteins 0.009 0.0915 0.0915
Mycobacterium ulcerans glutaminase 0.0317 0.3839 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Loa Loa (eye worm) abnormal epIthelia family member 0.0025 0.0075 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0312 0.0812
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.0479 0.1248
Brugia malayi Isocitrate dehydrogenase 0.0029 0.0134 0.0193
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0043 0.0312 0.0312
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.5897 0.5897
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0006 0.0126
Trichomonas vaginalis guanylate cyclase, putative 0.0043 0.0312 0.0812
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0043 0.0312 0.651
Brugia malayi laminin-like protein K08C7.3 precursor 0.0025 0.0075 0.0109
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0006 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0362 0.0362
Leishmania major trypanothione reductase 0.0043 0.0306 0.4949
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0246 0.0246
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0246 0.3984
Echinococcus granulosus dna polymerase eta 0.002 0.0013 0.0013
Brugia malayi cytochrome P450 0.0027 0.0109 0.0157
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0109 0.0284
Loa Loa (eye worm) glutaminase 2 0.0317 0.3839 0.555
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0043 0.0312 0.0812
Loa Loa (eye worm) hypothetical protein 0.0222 0.2622 0.3791
Loa Loa (eye worm) hypothetical protein 0.0058 0.0502 0.0725
Brugia malayi nuclear hormone receptor family member nhr-6 0.0105 0.1109 0.1603
Schistosoma mansoni nuclear hormone receptor 0.0105 0.1109 0.1109
Echinococcus multilocularis nuclear receptor nhr 48 0.0105 0.1109 0.1109
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0222 0.2622 0.2622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0362 0.0362
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0222 0.2622 0.2622
Schistosoma mansoni hypothetical protein 0.0039 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Schistosoma mansoni RAR-like nuclear receptor 0.0222 0.2622 0.2622
Toxoplasma gondii exonuclease III APE 0.0019 0.0006 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0246 0.0642
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0134 0.279
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0618 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0246 0.0246
Schistosoma mansoni nuclear receptor nhr-48 0.0105 0.1109 0.1109
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0117 0.1271 0.1271
Echinococcus multilocularis ecdysone induced protein 78C 0.0222 0.2622 0.2622
Brugia malayi Importin beta-1 subunit 0.0026 0.0092 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0262
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0571 0.0825
Schistosoma mansoni hypothetical protein 0.0053 0.0441 0.0441
Brugia malayi tailless protein 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0105 0.1109 0.1603
Loa Loa (eye worm) hypothetical protein 0.0038 0.0246 0.0356
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0043 0.0312 0.0812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0618 0.1611
Onchocerca volvulus 0.0105 0.1109 0.3825
Entamoeba histolytica hypothetical protein 0.0182 0.2105 1
Schistosoma mansoni retinoic acid receptor RXR 0.0323 0.3927 0.3927
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0893 0.1292
Schistosoma mansoni importin beta-1 0.0026 0.0092 0.0092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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