TDR Targets

Basic information

Technical information

TDR Targets ID: 211328
Name: (2E,4E,6E,8E)-8-(2,3-dimethylcyclohex-2-en-1- ylidene)-3,7-dimethylocta-2,4,6-trienoic acid
MW: 272.382 | Formula: C18H24O2
H donors: 1 H acceptors: 2 LogP: 4.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/1\CCCC(=C1C)C
InChi: 1S/C18H24O2/c1-13(7-5-8-14(2)12-18(19)20)11-17-10-6-9-15(3)16(17)4/h5,7-8,11-12H,6,9-10H2,1-4H3,(H,19,20)/b8-5+,13-7+,14-12+,17-11+
InChiKey: RPQYCEYLWVFLBS-FUJBVNLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E,4E,6E,8E)-8-(2,3-dimethylcyclohex-2-en-1-ylidene)-3,7-dimethyl-octa-2,4,6-trienoic acid
(2E,4E,6E,8E)-8-(2,3-dimethyl-1-cyclohex-2-enylidene)-3,7-dimethylocta-2,4,6-trienoic acid
(2E,4E,6E,8E)-8-(2,3-dimethyl-1-cyclohex-2-enylidene)-3,7-dimethyl-octa-2,4,6-trienoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	retinoid X receptor, alpha	Starlite/ChEMBL	References
Mus musculus	cellular retinoic acid binding protein II	Starlite/ChEMBL	References
Mus musculus	retinoic acid receptor, alpha	Starlite/ChEMBL	References
Gallus gallus	Cellular retinoic acid-binding protein I	Starlite/ChEMBL	References
Mus musculus	retinoid X receptor alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	Get druggable targets OG5_130073	All targets in OG5_130073
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131607	All targets in OG5_131607
Loa Loa (eye worm)	nuclear receptor nhr-7B	Get druggable targets OG5_131607	All targets in OG5_131607
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	Get druggable targets OG5_131607	All targets in OG5_131607
Echinococcus granulosus	retinoic acid receptor rxr beta a	Get druggable targets OG5_130073	All targets in OG5_130073
Schistosoma japonicum	ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative	Get druggable targets OG5_130073	All targets in OG5_130073
Brugia malayi	nuclear hormone receptor	Get druggable targets OG5_131607	All targets in OG5_131607
Schistosoma mansoni	retinoic acid receptor RXR	Get druggable targets OG5_130073	All targets in OG5_130073

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Cellular retinoic acid-binding protein I	137 aa	132 aa	28.8 %
Loa Loa (eye worm)	embryonic fatty acid-binding protein Bm-FAB-1	Cellular retinoic acid-binding protein I	137 aa	139 aa	24.5 %
Echinococcus granulosus	fatty acids and retinol binding protein	Cellular retinoic acid-binding protein I	137 aa	145 aa	33.8 %
Brugia malayi	ecdysteroid receptor	retinoid X receptor alpha	439 aa	352 aa	23.9 %
Brugia malayi	FAB1, identical	Cellular retinoic acid-binding protein I	137 aa	139 aa	25.2 %
Echinococcus granulosus	fatty acid binding protein FABP2	Cellular retinoic acid-binding protein I	137 aa	136 aa	37.5 %
Echinococcus multilocularis	fatty acids and retinol binding protein	Cellular retinoic acid-binding protein I	137 aa	145 aa	33.8 %
Brugia malayi	FAB1, identical	cellular retinoic acid binding protein II	138 aa	139 aa	28.1 %
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	Cellular retinoic acid-binding protein I	137 aa	133 aa	28.6 %
Brugia malayi	ecdysteroid receptor	retinoid X receptor, alpha	435 aa	352 aa	23.9 %
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	Cellular retinoic acid-binding protein I	137 aa	132 aa	32.6 %
Echinococcus granulosus	fatty acid binding protein FABP2	Cellular retinoic acid-binding protein I	137 aa	145 aa	31.7 %
Onchocerca volvulus	Mannose-1-phosphate guanyltransferase alpha homolog	Cellular retinoic acid-binding protein I	137 aa	123 aa	30.9 %
Echinococcus multilocularis	fatty acid binding protein FABP2	Cellular retinoic acid-binding protein I	137 aa	145 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0091	0.0852	0.1002
Onchocerca volvulus		0.0091	0.0852	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0091	0.0852	0.0837
Echinococcus granulosus	7TM GPCR rhodopsin	0.0091	0.0852	0.0985
Echinococcus granulosus	neuropeptides capa receptor	0.0091	0.0852	0.0985
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0102	0.0979	0.7701
Echinococcus granulosus	cpg binding protein	0.0031	0.0172	0.0183
Echinococcus multilocularis	g protein coupled receptor	0.0091	0.0852	0.0837
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0061	0.0507	0.1443
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.024	0.0268
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.029	0.0341
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0176	0.1816	1
Brugia malayi	neuropeptide F receptor	0.0091	0.0852	0.0951
Plasmodium falciparum	glutathione reductase	0.0044	0.0323	0.0666
Schistosoma mansoni	hypothetical protein	0.0418	0.4565	0.5369
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.024	0.0224
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0091	0.0852	0.0985
Brugia malayi	nuclear receptor RXR	0.0042	0.029	0.0324
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0102	0.0979	0.2751
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0711	0.0818
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.029	0.0323
Echinococcus granulosus	g protein coupled receptor	0.0091	0.0852	0.0985
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0102	0.0979	0.4541
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0075	0.0674	0.3199
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0443	0.0494
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Onchocerca volvulus		0.0041	0.0286	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0102	0.0979	0.2751
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0711	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0102	0.0979	0.4541
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.024	0.0268
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0323	0.2537
Echinococcus granulosus	neuropeptide receptor	0.0562	0.6191	0.7277
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0711	0.0793
Echinococcus multilocularis	neuropeptides capa receptor	0.0091	0.0852	0.0837
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0596	0.2043
Brugia malayi	ecdysteroid receptor	0.0079	0.0711	0.0793
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.0711	0.0695
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus multilocularis	serotonin receptor	0.0091	0.0852	0.0837
Schistosoma mansoni	nuclear receptor	0.0037	0.024	0.0281
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0044	0.0323	0.0143
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.024	0.0224
Echinococcus granulosus	g protein coupled receptor	0.0091	0.0852	0.0985
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0286	0.027
Plasmodium falciparum	thioredoxin reductase	0.0128	0.1271	0.6597
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0246	0.0274
Echinococcus granulosus	neuropeptide FF receptor 2	0.0091	0.0852	0.0985
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0711	0.0793
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0102	0.0979	0.2751
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0044	0.0323	0.0666
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0148	0.1496	0.1744
Leishmania major	cytochrome p450-like protein	0.0102	0.0979	0.7701
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	cytochrome P450	0.0102	0.0979	0.1092
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0641	0.0753
Brugia malayi	hypoxia-induced factor 1	0.0171	0.1758	0.1961
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Onchocerca volvulus		0.0091	0.0852	0.0754
Onchocerca volvulus		0.0091	0.0852	0.0754
Onchocerca volvulus		0.0037	0.024	0.0094
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0079	0.0716	0.0799
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0153	0.017
Schistosoma mansoni	lamin	0.003	0.0157	0.0183
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0263	0.2803	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus granulosus	G protein coupled receptor 139	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0711	0.0793
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0102	0.0979	0.2751
Onchocerca volvulus	Huntingtin homolog	0.0138	0.1386	0.1329
Trypanosoma cruzi	casein kinase II, putative	0.0079	0.0716	0.5634
Plasmodium falciparum	glutathione reductase	0.0128	0.1271	0.6597
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0286	0.0023
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0102	0.0979	0.2751
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	opsin-like receptor	0.0091	0.0852	0.1002
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0711	0.0695
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0044	0.0323	0.2537
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0711	0.0835
Echinococcus granulosus	neuropeptides capa receptor	0.0091	0.0852	0.0985
Brugia malayi	ORL1-like opioid receptor	0.0091	0.0852	0.0951
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0711	0.0793
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0079	0.0716	0.3128
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Echinococcus granulosus	tm gpcr rhodopsin	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0091	0.0852	0.0951
Schistosoma mansoni	opsin-like receptor	0.0091	0.0852	0.1002
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0102	0.0979	0.2751
Echinococcus granulosus	lamin dm0	0.003	0.0157	0.0165
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0711	0.0818
Onchocerca volvulus		0.003	0.0157	0.0004
Brugia malayi	Dopamine receptor	0.0091	0.0852	0.0951
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.024	0.0281
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0044	0.0323	0.0258
Onchocerca volvulus		0.0091	0.0852	0.0754
Onchocerca volvulus		0.0091	0.0852	0.0754
Echinococcus granulosus	neuropeptide receptor A26	0.0091	0.0852	0.0985
Brugia malayi	Dopamine receptor protein 1	0.0091	0.0852	0.0951
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0091	0.0852	0.0951
Brugia malayi	Cytochrome P450 family protein	0.0124	0.1225	0.1366
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0711	0.0835
Schistosoma mansoni	neuropeptide F-like receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0148	0.1496	0.176
Echinococcus multilocularis	neuropeptides capa receptor	0.0091	0.0852	0.0837
Toxoplasma gondii	CMGC kinase, CK2 family	0.0079	0.0716	0.3942
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0044	0.0323	0.0236
Loa Loa (eye worm)	G-protein coupled receptor	0.0091	0.0852	0.0951
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0102	0.0979	0.539
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0091	0.0852	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1816	0.2025
Plasmodium falciparum	plasmepsin I	0.0148	0.1496	0.8005
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0711	0.0835
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0286	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0168
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.024	0.0263
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0237	0.0221
Brugia malayi	glutathione reductase	0.0128	0.1271	0.1418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0091	0.0852	0.0985
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0102	0.0979	0.4541
Loa Loa (eye worm)	cytochrome P450 family protein	0.0112	0.1092	0.1218
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.0258
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0102	0.0979	0.4541
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0083	0.0765	0.0749
Brugia malayi	Pepsin A precursor	0.0035	0.0216	0.0241
Brugia malayi	RE15519p	0.0091	0.0852	0.0951
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0091	0.0852	0.0837
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.024	0.0281
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.024	0.0094
Schistosoma mansoni	cytochrome P450	0.0102	0.0979	0.1151
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0113	0.11	0.1294
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.024	0.0281
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus multilocularis	g protein coupled receptor	0.0091	0.0852	0.0837
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0102	0.0979	0.2751
Onchocerca volvulus		0.0079	0.0711	0.0601
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0061	0.0507	0.1237
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.029	0.0324
Echinococcus multilocularis	neuropeptide receptor	0.0091	0.0852	0.0837
Mycobacterium ulcerans	lipase LipD	0.0041	0.0286	0.0023
Onchocerca volvulus		0.0037	0.024	0.0094
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0091	0.0852	0.0837
Brugia malayi	Serotonin receptor	0.0091	0.0852	0.0951
Schistosoma mansoni	biogenic amine receptor	0.0091	0.0852	0.1002
Toxoplasma gondii	aspartyl protease	0.0035	0.0216	0.1186
Leishmania major	hypothetical protein, conserved	0.0041	0.0286	0.2254
Echinococcus multilocularis	allatostatin A receptor	0.0091	0.0852	0.0837
Loa Loa (eye worm)	CYP4Cod1	0.0112	0.1092	0.1218
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0286	0.0441
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0083	0.0765	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0091	0.0852	0.0985
Echinococcus granulosus	fatty acid binding protein FABP2	0.0083	0.0765	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	putative neuropeptide receptor	0.0091	0.0852	0.0951
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0286	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0044	0.0323	0.0143
Onchocerca volvulus		0.003	0.0157	0.0004
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0102	0.0979	0.2751
Brugia malayi	aspartic protease BmAsp-2, identical	0.0035	0.0216	0.0241
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0102	0.0979	0.2751
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0711	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0083	0.0765	0.0853
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0176	0.1816	0.212
Brugia malayi	neuropeptide F receptor	0.0091	0.0852	0.0951
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0044	0.0323	0.0258
Echinococcus granulosus	g-protein coupled receptor	0.0091	0.0852	0.0985
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0102	0.0979	0.4541
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Echinococcus granulosus	7tm_1 domain containing protein	0.0091	0.0852	0.0985
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.0379
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.2483
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	conserved hypotetical protein	0.0037	0.024	0.0268
Onchocerca volvulus	Bile acid receptor homolog	0.0079	0.0711	0.0601
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0596	0.07
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0115	0.1128	0.3343
Brugia malayi	beta-lactamase family protein	0.0041	0.0286	0.0319
Echinococcus multilocularis	neuropeptide receptor A26	0.0091	0.0852	0.0837
Toxoplasma gondii	aspartyl protease ASP3	0.0035	0.0216	0.1186
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0711	0.0793
Brugia malayi	G-protein coupled receptor	0.0091	0.0852	0.0951
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0102	0.0979	0.2751
Brugia malayi	G-protein coupled receptor	0.0091	0.0852	0.0951
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0711	0.0835
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0711	0.0793
Trichomonas vaginalis	glutathione reductase, putative	0.0044	0.0323	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Trypanosoma brucei	cytochrome P450, putative	0.0112	0.1092	0.8578
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Brugia malayi	Serotonin receptor	0.0091	0.0852	0.0951
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Brugia malayi	beta-lactamase	0.0041	0.0286	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0102	0.0979	0.4541
Brugia malayi	steroid hormone receptor	0.0079	0.0711	0.0793
Loa Loa (eye worm)	cytochrome P450 family protein	0.0112	0.1092	0.1218
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.0175
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0091	0.0852	0.1002
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0044	0.0323	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0286	0.2254
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0711	0.0793
Onchocerca volvulus		0.0035	0.0216	0.0068
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0102	0.0979	0.2751
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0596	0.2043
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0102	0.0979	0.4541
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	G-protein coupled receptor	0.0091	0.0852	0.0951
Mycobacterium leprae	Conserved hypothetical protein	0.0102	0.0979	0.4528
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0102	0.0979	0.2751
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0152	0.1545	0.1723
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0443	0.0494
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0044	0.0323	0.2537
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0091	0.0852	0.0951
Schistosoma mansoni	growth hormone secretagogue receptor	0.0091	0.0852	0.1002
Toxoplasma gondii	ABC1 family protein	0.0041	0.0286	0.1574
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.024	0.0268
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	histamine h1 receptor	0.0091	0.0852	0.1002
Echinococcus multilocularis	dro:myosuppressin receptor	0.0091	0.0852	0.0837
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0091	0.0852	0.1002
Trypanosoma brucei	Casein kinase II	0.0079	0.0716	0.5603
Echinococcus multilocularis	dnaJ subfamily B	0.0418	0.4565	0.4556
Entamoeba histolytica	casein kinase, putative	0.0079	0.0716	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0019
Schistosoma mansoni	hypothetical protein	0.0038	0.0246	0.0288
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.0596	0.058
Brugia malayi	Cytochrome P450 family protein	0.0112	0.1092	0.1218
Schistosoma mansoni	hypothetical protein	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0711	0.0835
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0286	0.0319
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0091	0.0852	0.0837
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.024	0.0263
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0091	0.0852	0.0985
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0711	0.0818
Echinococcus granulosus	thioredoxin glutathione reductase	0.0128	0.1271	0.1479
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0102	0.0979	0.2751
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Schistosoma mansoni	amine GPCR	0.0091	0.0852	0.1002
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0091	0.0852	0.1002
Onchocerca volvulus		0.0091	0.0852	0.0754
Echinococcus granulosus	dnaJ subfamily B	0.0418	0.4565	0.536
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Echinococcus multilocularis	cpg binding protein	0.0031	0.0172	0.0155
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0113	0.11	0.1294
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0091	0.0852	0.1002
Echinococcus granulosus	neuropeptide Y receptor	0.0091	0.0852	0.0985
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.029	0.0274
Schistosoma mansoni	hypothetical protein	0.0037	0.0237	0.0278
Loa Loa (eye worm)	neuropeptide F receptor	0.0091	0.0852	0.0951
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.0596	0.328
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0075	0.0674	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0711	0.0695
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0091	0.0852	0.0985
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0711	0.0835
Schistosoma mansoni	amine GPCR	0.0091	0.0852	0.1002
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0323	0.0666
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0157	0.0175
Echinococcus multilocularis	lamin dm0	0.003	0.0157	0.014
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0237	0.0259
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0102	0.0979	0.4541
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.0641	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1496	0.1669
Schistosoma mansoni	nuclear receptor	0.0037	0.024	0.0281
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0102	0.0979	0.2751
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.024	0.0263
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.024	0.0224
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0044	0.0323	0.2483
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0716	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.029	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0102	0.0979	0.4541
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0148	0.1496	0.1669
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.024	0.0224
Plasmodium vivax	aspartyl proteinase, putative	0.0148	0.1496	0.8005
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	hypothetical protein	0.0091	0.0852	0.1002
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0153	0.017
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0102	0.0979	0.2751
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0711	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0216	0.0241
Leishmania major	cytochrome p450-like protein	0.0112	0.1092	0.8588
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0596	0.07
Brugia malayi	sulfakinin receptor protein	0.0091	0.0852	0.0951
Brugia malayi	larval opioid receptor	0.0091	0.0852	0.0951
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.0765	0.8501	0.8499
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.024	0.0268
Echinococcus multilocularis	neuropeptide Y receptor	0.0091	0.0852	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0017	0.0019
Echinococcus granulosus	tm gpcr rhodopsin	0.0091	0.0852	0.0985
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0113	0.11	0.1085
Toxoplasma gondii	hypothetical protein	0.0061	0.0507	0.2791
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.0596	0.0683
Echinococcus granulosus	tar DNA binding protein	0.0072	0.0641	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0042	0.029	0.0324
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.029	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Brugia malayi	AKH receptor	0.0091	0.0852	0.0951
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0091	0.0852	0.0985
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Onchocerca volvulus		0.0091	0.0852	0.0754
Loa Loa (eye worm)	glutathione reductase	0.0128	0.1271	0.1418
Schistosoma mansoni	amine GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	nuclear receptor NHR-67	0.0037	0.024	0.0268
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.024	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0042	0.029	0.0324
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0091	0.0852	0.1002
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0711	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Toxoplasma gondii	melibiase subfamily protein	0.0113	0.11	0.6058
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0711	0.0835
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0711	0.0695
Onchocerca volvulus		0.0091	0.0852	0.0754
Brugia malayi	follicle stimulating hormone receptor	0.0091	0.0852	0.0951
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0711	0.0818
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0102	0.0979	0.7701
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Schistosoma mansoni	intermediate filament proteins	0.003	0.0157	0.0183
Brugia malayi	hypothetical protein	0.0042	0.029	0.0324
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0711	0.0793
Brugia malayi	hypothetical protein	0.0138	0.1386	0.1547
Schistosoma mansoni	fatty acid binding protein	0.0083	0.0765	0.0899
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0091	0.0852	0.0951
Schistosoma mansoni	neuropeptide receptor	0.0562	0.6191	0.7282
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	peptidase Clp (S14 family)	0.0176	0.1816	0.2135
Plasmodium vivax	plasmepsin IV, putative	0.0148	0.1496	0.8005
Echinococcus granulosus	serotonin receptor	0.0091	0.0852	0.0985
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0091	0.0852	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	nuclear hormone receptor	0.0806	0.8964	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0176	0.1816	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Schistosoma mansoni	cpg binding protein	0.0031	0.0172	0.0201
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0091	0.0852	0.0985
Plasmodium falciparum	plasmepsin II	0.0148	0.1496	0.8005
Brugia malayi	RNA binding protein	0.0072	0.0641	0.0715
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0711	0.0793
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0113	0.11	0.1277
Schistosoma mansoni	single-minded	0.0055	0.0446	0.0524
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0711	0.0835
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0711	0.0793
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0061	0.0507	0.1821
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0711	0.0793
Brugia malayi	putative neuropeptide receptor NPR1	0.0091	0.0852	0.0951
Echinococcus granulosus	allatostatin A receptor	0.0091	0.0852	0.0985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0113	0.11	0.1085
Brugia malayi	hypothetical protein	0.0042	0.029	0.0324
Onchocerca volvulus		0.0091	0.0852	0.0754
Echinococcus multilocularis	g-protein coupled receptor	0.0091	0.0852	0.0837
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0091	0.0852	0.0837
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.029	0.0324
Mycobacterium tuberculosis	Probable oxidoreductase	0.0044	0.0323	0.0143
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0711	0.0695
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.0641	0.0626
Brugia malayi	Cytochrome P450 family protein	0.0112	0.1092	0.1218
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0711	0.0793
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0091	0.0852	0.0951
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0148	0.1496	0.1482
Schistosoma mansoni	biogenic amine receptor	0.0091	0.0852	0.1002
Echinococcus multilocularis	geminin	0.0381	0.4145	0.4135
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.2483
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.024	0.0268
Echinococcus granulosus	geminin	0.0381	0.4145	0.4866
Echinococcus granulosus	g protein coupled receptor	0.0091	0.0852	0.0985
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0102	0.0979	0.4541
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1386	0.1547
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0711	0.0793
Echinococcus multilocularis	somatostatin receptor	0.0091	0.0852	0.0837
Brugia malayi	nuclear receptor RXR	0.0037	0.024	0.0268
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Brugia malayi	aspartic protease BmAsp-1, identical	0.0035	0.0216	0.0241
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0079	0.0716	0.3128
Brugia malayi	hypothetical protein	0.0037	0.024	0.0268
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0286	0.0336
Echinococcus granulosus	intermediate filament protein	0.003	0.0157	0.0165
Echinococcus granulosus	fatty acid binding protein FABP2	0.0083	0.0765	0.0881
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0044	0.0323	0.0666
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0091	0.0852	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0102	0.0979	0.4541
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0148	0.1496	1
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0102	0.0979	0.4541
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0079	0.0716	0.0701
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0711	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0769	0.8544	0.9531
Loa Loa (eye worm)	TYRA-2 protein	0.0091	0.0852	0.0951
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0323	0.2537
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.0765	0.8501	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0102	0.0979	0.7684
Echinococcus granulosus	dro:myosuppressin receptor	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0042	0.029	0.0324
Brugia malayi	G protein-coupled receptor F59B2.13	0.0091	0.0852	0.0951
Schistosoma mansoni	neuropeptide receptor	0.0091	0.0852	0.1002
Schistosoma mansoni	coup transcription factor	0.0079	0.0711	0.0835
Onchocerca volvulus		0.0091	0.0852	0.0754
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0102	0.0979	0.2751
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0091	0.0852	0.0951
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0115	0.1128	0.1113
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0711	0.0818
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0091	0.0852	0.0837
Schistosoma mansoni	amine GPCR	0.0091	0.0852	0.1002
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0017	0.0019
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0148	0.1496	0.8241
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0017	0.0019
Schistosoma mansoni	cpg binding protein	0.0031	0.0172	0.0201
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.0306
Echinococcus granulosus	neuropeptide s receptor	0.0091	0.0852	0.0985
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0711	0.0793
Toxoplasma gondii	NADPH-glutathione reductase	0.0044	0.0323	0.1773
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0711	0.0695
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.024	0.0281
Echinococcus multilocularis	lamin	0.003	0.0157	0.014
Echinococcus multilocularis	transfer RNA-Lys	0.0041	0.0283	0.0267
Echinococcus granulosus	fmrfamide receptor	0.0091	0.0852	0.0985
Echinococcus granulosus	sex peptide receptor	0.0091	0.0852	0.0985
Brugia malayi	beta-lactamase family protein	0.0041	0.0286	0.0319
Brugia malayi	hypothetical protein	0.0185	0.1921	0.2143
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.024	0.0263
Loa Loa (eye worm)	thioredoxin reductase	0.0128	0.1271	0.1418
Brugia malayi	nuclear hormone receptor	0.0079	0.0711	0.0793
Onchocerca volvulus		0.0091	0.0852	0.0754
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.0641	0.0715
Leishmania major	cytochrome p450-like protein	0.0102	0.0979	0.7701
Loa Loa (eye worm)	hypothetical protein	0.0042	0.029	0.0324
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0286	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0216	0.0241
Brugia malayi	tailless protein	0.0037	0.024	0.0268
Schistosoma mansoni	cathepsin D (A01 family)	0.0436	0.4764	0.5604
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.024	0.0281
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0596	0.2043
Brugia malayi	Casein kinase II, alpha chain	0.0079	0.0716	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	cpg binding protein	0.0029	0.0153	0.0179
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0641	0.0753
Onchocerca volvulus		0.0091	0.0852	0.0754
Onchocerca volvulus		0.0041	0.0286	0.0144
Echinococcus granulosus	lamin	0.003	0.0157	0.0165
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.024	0.0224
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0102	0.0979	0.4541
Schistosoma mansoni	zinc finger protein	0.0037	0.024	0.0281
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0091	0.0852	0.0837
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0102	0.0979	0.4541
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0035	0.0216	0.0241
Toxoplasma gondii	thioredoxin reductase	0.0128	0.1271	0.7
Echinococcus multilocularis	musashi	0.003	0.0157	0.014
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0286	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0112	0.1092	0.5277
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0044	0.0323	0.036
Schistosoma mansoni	opsin-like receptor	0.0091	0.0852	0.1002
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0091	0.0852	0.0951
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0102	0.0979	0.2751
Echinococcus granulosus	single minded 2	0.0056	0.0455	0.0517
Schistosoma mansoni	hypothetical protein	0.0091	0.0852	0.1002
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0286	0.2254
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus granulosus	hypothetical protein	0.0091	0.0852	0.0985
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0033	0.0189	0.0211
Loa Loa (eye worm)	cytochrome P450 family protein	0.0124	0.1225	0.1366
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0176	0.1816	1
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0035	0.0216	0.0241
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0091	0.0852	0.0837
Schistosoma mansoni	neuropeptide f receptor 76f	0.0091	0.0852	0.1002
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0091	0.0852	0.1002
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0102	0.0979	0.4541
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0091	0.0852	0.0985
Echinococcus granulosus	cytochrome P450 2K1	0.0102	0.0979	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0711	0.0793
Loa Loa (eye worm)	cytochrome P450	0.0102	0.0979	0.1092
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0115	0.1128	0.5502
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.024	0.0268
Echinococcus granulosus	tm gpcr rhodopsin	0.0091	0.0852	0.0985
Echinococcus multilocularis	neuropeptide receptor	0.0562	0.6191	0.6184
Brugia malayi	Dopamine receptor protein 2	0.0091	0.0852	0.0951
Trypanosoma cruzi	trypanothione reductase, putative	0.0128	0.1271	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Brugia malayi	Melatonin receptor type 1A	0.0091	0.0852	0.0951
Plasmodium vivax	thioredoxin reductase, putative	0.0128	0.1271	0.6597
Schistosoma mansoni	hypothetical protein	0.0381	0.4145	0.4875
Trypanosoma brucei	trypanothione reductase	0.0128	0.1271	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0102	0.0979	0.2751
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0711	0.0793
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0091	0.0852	0.0837
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.024	0.0268
Echinococcus multilocularis	g protein coupled receptor	0.0091	0.0852	0.0837
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0091	0.0852	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0091	0.0852	0.0754
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0711	0.0695
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0641	0.0753
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0323	0.2537
Schistosoma mansoni	amine GPCR	0.0091	0.0852	0.1002
Brugia malayi	TAR-binding protein	0.0072	0.0641	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Toxoplasma gondii	aspartyl protease ASP1	0.0148	0.1496	0.8241
Brugia malayi	Cytochrome P450 family protein	0.0102	0.0979	0.1092
Plasmodium falciparum	plasmepsin IV	0.0148	0.1496	0.8005
Brugia malayi	Melibiase family protein	0.0075	0.0674	0.0751
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0157	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.0596	0.123
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0711	0.0793
Echinococcus multilocularis	G protein coupled receptor 139	0.0562	0.6191	0.6184
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0286	0.0023
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0102	0.0979	0.2751
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0246	0.0274
Echinococcus granulosus	neuropeptide receptor	0.0091	0.0852	0.0985
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0033	0.0189	0.0211
Schistosoma mansoni	neuropeptide F-like receptor	0.0091	0.0852	0.1002
Leishmania major	casein kinase II, putative	0.0079	0.0716	0.5634
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0091	0.0852	0.0837
Loa Loa (eye worm)	melatonin receptor type 1A	0.0091	0.0852	0.0951
Brugia malayi	UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II	0.0765	0.8501	0.9484
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0711	0.0793
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0128	0.1271	0.3913
Loa Loa (eye worm)	DR-78	0.0037	0.024	0.0268
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0711	0.0793
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0711	0.0695
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.0596	0.4689
Onchocerca volvulus		0.0035	0.0216	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0765	0.8501	0.9484
Echinococcus granulosus	casein kinase ii subunit alpha	0.0079	0.0716	0.0825
Echinococcus multilocularis	neuropeptide s receptor	0.0091	0.0852	0.0837
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0286	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1921	0.2143
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0286	0.0318
Echinococcus granulosus	somatostatin receptor	0.0091	0.0852	0.0985
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0044	0.0323	0.0143
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.024	0.0263
Schistosoma mansoni	hypothetical protein	0.0102	0.0979	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0711	0.0793
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0091	0.0852	0.1002
Giardia lamblia	Kinase, CMGC CK2	0.0079	0.0716	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	memapsin-2 (A01 family)	0.0035	0.0216	0.0253
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0091	0.0852	0.0951
Schistosoma mansoni	hypothetical protein	0.0381	0.4145	0.4875
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0711	0.0835
Trichomonas vaginalis	mercuric reductase, putative	0.0044	0.0323	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Mycobacterium leprae	putative cytochrome p450	0.0102	0.0979	0.4528
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0091	0.0852	0.0837
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0035	0.0216	0.1186
Echinococcus granulosus	orexin receptor type 2	0.0091	0.0852	0.0985
Echinococcus multilocularis	serotonin receptor	0.0091	0.0852	0.0837
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0102	0.0979	0.7701
Onchocerca volvulus		0.0091	0.0852	0.0754
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0091	0.0852	0.0837
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.024	0.0268
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0711	0.0835
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0128	0.1271	0.1257
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0848	0.9435	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0443	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0157	0.0175
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0286	0.0319
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0451	0.2479
Schistosoma mansoni	myosin xvIII	0.0091	0.0852	0.1002
Onchocerca volvulus		0.0152	0.1545	0.15
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Trichomonas vaginalis	CMGC family protein kinase	0.0079	0.0716	0.3552
Echinococcus granulosus	neuropeptide Y receptor	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0091	0.0852	0.0837
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0176	0.1816	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Echinococcus multilocularis		0.0102	0.0979	0.0964
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	neuropeptide receptor	0.0091	0.0852	0.1002
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0102	0.0979	0.7701
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Trypanosoma cruzi	cytochrome P450, putative	0.0112	0.1092	0.8588
Echinococcus granulosus	peptidase Clp S14 family	0.0115	0.1128	0.131
Schistosoma mansoni	cathepsin D (A01 family)	0.0436	0.4764	0.5604
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.0765	0.8501	1
Onchocerca volvulus		0.0041	0.0286	0.0144
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0113	0.11	0.1294
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0711	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0044	0.0323	0.0666
Brugia malayi	Thioredoxin reductase	0.0128	0.1271	0.1418
Plasmodium vivax	glutathione reductase, putative	0.0128	0.1271	0.6597
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0176	0.1816	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0037	0.024	0.0268
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0091	0.0852	0.0985
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0017	0.0019
Onchocerca volvulus	Huntingtin homolog	0.0138	0.1386	0.1329
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0102	0.0979	0.2751
Onchocerca volvulus		0.0091	0.0852	0.0754
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0711	0.0818
Echinococcus multilocularis	fmrfamide receptor	0.0091	0.0852	0.0837
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	neuropeptide F receptor	0.0091	0.0852	0.0951
Loa Loa (eye worm)	RNA binding protein	0.0072	0.0641	0.0715
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0102	0.0979	0.4541
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0102	0.0979	0.4541
Trypanosoma cruzi	cytochrome P450, putative	0.0112	0.1092	0.8588
Brugia malayi	PAS domain containing protein	0.0055	0.0446	0.0497
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.029	0.0341
Brugia malayi	G protein-coupled receptor	0.0091	0.0852	0.0951
Brugia malayi	hypothetical protein	0.0091	0.0852	0.0951
Onchocerca volvulus		0.0091	0.0852	0.0754
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0091	0.0852	0.0951
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0434	0.4741	0.4732
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0102	0.0979	0.4541
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0711	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	aspartyl protease 6	0.0035	0.0216	0.0241
Brugia malayi	intermediate filament protein	0.003	0.0157	0.0175
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0711	0.0793
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0711	0.0793
Schistosoma mansoni	retinoic acid receptor RXR	0.0475	0.5211	0.613
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0171	0.1758	0.1961
Brugia malayi	hypothetical protein	0.0037	0.024	0.0268
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.024	0.0094
Onchocerca volvulus		0.0091	0.0852	0.0754
Brugia malayi	hypothetical protein	0.0037	0.0237	0.0264
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0641	0.0753
Brugia malayi	GnHR receptor homolog	0.0091	0.0852	0.0951
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0475	0.5211	0.6123
Echinococcus multilocularis	sex peptide receptor	0.0091	0.0852	0.0837
Echinococcus granulosus	biogenic amine 5HT receptor	0.0091	0.0852	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Echinococcus granulosus	rhodopsin orphan GPCR	0.0091	0.0852	0.0985
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0091	0.0852	0.0985
Schistosoma mansoni	fatty acid binding protein	0.0083	0.0765	0.0899
Schistosoma mansoni	protein kinase	0.0079	0.0716	0.0842
Leishmania major	trypanothione reductase	0.0128	0.1271	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0806	0.8964	1
Plasmodium falciparum	plasmepsin VI	0.0148	0.1496	0.8005
Onchocerca volvulus		0.0041	0.0283	0.014
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0091	0.0852	0.1002
Brugia malayi	bHLH-PAS transcription factor	0.0041	0.0283	0.0316
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0091	0.0852	0.1002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0091	0.0852	0.0837
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0237	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0674	0.0751
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0044	0.0323	0.0666
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0044	0.0323	0.2483
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0091	0.0852	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1386	0.1547
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0113	0.11	0.1294
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0102	0.0979	0.4541
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0115	0.1128	0.3343
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0102	0.0979	0.4541
Plasmodium vivax	unspecified product	0.0079	0.0716	0.3128
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0711	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0286	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0176	0.1816	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0055	0.0446	0.0524
Echinococcus multilocularis	neuropeptide Y receptor	0.0091	0.0852	0.0837
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0083	0.0765	0.0749
Brugia malayi	Probable ClpP-like protease	0.0176	0.1816	0.2025
Schistosoma mansoni	biogenic amine receptor	0.0091	0.0852	0.1002
Echinococcus multilocularis	fmrfamide receptor	0.0091	0.0852	0.0837
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0044	0.0323	0.036
Echinococcus multilocularis	orexin receptor type 2	0.0091	0.0852	0.0837
Brugia malayi	nuclear receptor NHR-88	0.0037	0.024	0.0268
Schistosoma mansoni	lamin	0.003	0.0157	0.0183
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0091	0.0852	0.0837
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0035	0.0216	0.0253
Schistosoma mansoni	neuropeptide receptor	0.0091	0.0852	0.1002
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0091	0.0852	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0443	0.0494
Brugia malayi	hypothetical protein	0.0035	0.0216	0.0241
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0711	0.0695
Brugia malayi	hypothetical protein	0.0035	0.0216	0.0241
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0526	0.0618
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0061	0.0507	0.1821
Brugia malayi	ecdysone receptor	0.0037	0.024	0.0268
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0641	0.0753
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0323	0.2537
Schistosoma mansoni	adenoreceptor	0.0091	0.0852	0.1002
Onchocerca volvulus		0.0091	0.0852	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.0951
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0075	0.0674	0.0792
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.0641	0.0715

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 32 nM	Antitumour activity in Mouse Skin Papilloma model	ChEMBL.	8809153
ED50 (functional)	= 32 nM	Antitumour activity in Mouse Skin Papilloma model	ChEMBL.	8809153
ED50 (functional)	= 50 nM	Antitumour activity in Mouse Skin Papilloma model	ChEMBL.	8809153
IC50 (binding)	= 55 nM	Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
IC50 (binding)	= 55 nM	Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
IC50 (binding)	> 2000 nM	Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
IC50 (binding)	> 2000 nM	Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha	ChEMBL.	8809153
IC50 (binding)	> 2000 nM	Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha	ChEMBL.	8809153
IC50 (binding)	= 1.3 uM	Inhibition of [3H]-ATRA binding to chick skin Cytoplasmic retinoic acid binding protein	ChEMBL.	8809153
IC50 (binding)	= 1.3 uM	Inhibition of [3H]-ATRA binding to chick skin Cytoplasmic retinoic acid binding protein	ChEMBL.	8809153
IC50 (binding)	> 10 uM	Inhibition of [3H]-ATRA binding to chick skin Cytoplasmic retinoic acid binding protein	ChEMBL.	8809153
Inhibition (binding)	= 0 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha	ChEMBL.	8809153
Inhibition (binding)	= 0 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha	ChEMBL.	8809153
Inhibition (binding)	= 10 %	Inhibition of chick skin Cytoplasmic retinoic acid binding protein at 100-fold excess ligand	ChEMBL.	8809153
Inhibition (binding)	= 10 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
Inhibition (binding)	= 40 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha	ChEMBL.	8809153
Inhibition (binding)	= 90 %	Inhibition of chick skin Cytoplasmic retinoic acid binding protein at 100-fold excess ligand	ChEMBL.	8809153
Inhibition (binding)	= 90 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
Inhibition (binding)	= 90 %	Inhibition of chick skin Cytoplasmic retinoic acid binding protein at 100-fold excess ligand	ChEMBL.	8809153
Inhibition (binding)	= 90 %	Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha	ChEMBL.	8809153
Kd (binding)	= 1.2 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1	ChEMBL.	8809153
Kd (binding)	= 1.2 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1	ChEMBL.	8809153
Kd (binding)	= 13 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 2	ChEMBL.	8809153
Kd (binding)	= 13 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 2	ChEMBL.	8809153
Kd (binding)	= 120 nM	Inhibition of binding to human Retinoic acid receptor RXR DEF domain	ChEMBL.	8809153
Kd (binding)	> 200 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1	ChEMBL.	8809153
Kd (binding)	> 200 nM	Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 2	ChEMBL.	8809153
Kd (binding)	> 200 nM	Inhibition of binding to human Retinoic acid receptor RXR DEF domain	ChEMBL.	8809153
Kd (binding)	> 200 nM	Inhibition of binding to human Retinoic acid receptor RXR DEF domain	ChEMBL.	8809153
Reduction (functional)	> 50 %	Percentage papilloma reduction (81) at 45.9 nmol dose 1 hr prior to TPA	ChEMBL.	8809153
Reduction (functional)	= 490 %	Percentage papilloma reduction (81) at 45.9 nmol dose 1 hr prior to TPA	ChEMBL.	8809153
Reduction (functional)	= 490 %	Percentage papilloma reduction (81) at 45.9 nmol dose 1 hr prior to TPA	ChEMBL.	8809153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL122823
PubChem: 10707357

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 211328