Detailed information for compound 234114

Basic information

Technical information
  • TDR Targets ID: 234114
  • Name: 1-(4-chlorophenyl)-4-[3-phenyl-3-[4-(trifluor omethyl)phenoxy]propyl]piperazine
  • MW: 474.946 | Formula: C26H26ClF3N2O
  • H donors: 0 H acceptors: 0 LogP: 6.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1CCN(CC1)CCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C26H26ClF3N2O/c27-22-8-10-23(11-9-22)32-18-16-31(17-19-32)15-14-25(20-4-2-1-3-5-20)33-24-12-6-21(7-13-24)26(28,29)30/h1-13,25H,14-19H2
  • InChiKey: SMCJVPYCSOVUNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0113 0.0601 0.1014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0079 0.0129
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0053 0.0185 0.0379
Trypanosoma brucei unspecified product 0.0066 0.0276 0.0593
Mycobacterium tuberculosis Conserved hypothetical protein 0.034 0.2165 0.4401
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0059 0.0224 0.2347
Chlamydia trachomatis pyruvate kinase 0.0038 0.0079 0.2212
Echinococcus granulosus expressed protein 0.0425 0.2754 0.2723
Schistosoma mansoni lozenge 0.0063 0.0253 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0203 0.042
Echinococcus granulosus biogenic amine 5HT receptor 0.03 0.1891 0.1857
Brugia malayi CXXC zinc finger family protein 0.0038 0.0081 0.0066
Loa Loa (eye worm) runx1 0.0063 0.0253 0.0427
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0095 0.009
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0095 0.0087
Onchocerca volvulus 0.0501 0.3285 0.4793
Echinococcus granulosus Solute carrier family 22 5 0.1178 0.7959 0.795
Mycobacterium ulcerans hypothetical protein 0.0113 0.0601 0.1503
Trypanosoma brucei trypanothione reductase 0.0153 0.0878 0.2008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0037 0.0031
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.006 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0601 0.1357
Plasmodium vivax glutathione reductase, putative 0.0153 0.0878 1
Schistosoma mansoni survival motor neuron protein 0.0055 0.0195 0.0172
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0095 0.0035
Mycobacterium tuberculosis Conserved protein 0.0113 0.0601 0.1101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0601 0.1014
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0053 0.0185 0.1887
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0601 0.1503
Echinococcus multilocularis cpg binding protein 0.0038 0.0081 0.0058
Leishmania major trypanothione reductase 0.0153 0.0878 0.2008
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0079 0.0133
Schistosoma mansoni pyruvate kinase 0.0038 0.0079 0.0055
Brugia malayi hypothetical protein 0.0268 0.1669 0.2765
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0044 0.0121 0.0097
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0068 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.006 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0125 0.0682 0.1549
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0153 0.0878 0.1685
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0673 0.1526
Plasmodium vivax thioredoxin reductase, putative 0.0153 0.0878 1
Onchocerca volvulus 0.0127 0.0694 0.0919
Loa Loa (eye worm) hypothetical protein 0.0501 0.3285 0.5545
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0645 0.4274 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0049 0.0291
Toxoplasma gondii NADPH-glutathione reductase 0.0053 0.0185 0.1887
Echinococcus multilocularis disco interacting protein 2 0.0044 0.0121 0.0097
Mycobacterium tuberculosis Putative ferredoxin reductase 0.035 0.2235 0.4549
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0049 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0601 0.6756
Loa Loa (eye worm) hypothetical protein 0.0268 0.1669 0.2817
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Plasmodium falciparum glutathione reductase 0.0153 0.0878 1
Trichomonas vaginalis esterase, putative 0.0113 0.0601 0.0837
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0049 0.0291
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0095 0.0168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0883 0.5924 1
Plasmodium falciparum glutathione reductase 0.0053 0.0185 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Schistosoma mansoni hypothetical protein 0.0055 0.0195 0.0172
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0601 0.1101
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0616 0.1394
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0095 0.0836
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0624 0.413 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0582 0.1312
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0049 0.0291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0205 0.1235 0.2029
Echinococcus multilocularis Protein lozenge 0.0063 0.0253 0.0229
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0053 0.0185 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.032 0.0697
Plasmodium falciparum pyruvate kinase 0.0038 0.0079 0.0644
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0305 0.1927 0.4477
Schistosoma mansoni microtubule-associated protein tau 0.1473 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.1235 0.285
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0601 0.0578
Schistosoma mansoni rotamase 0.0032 0.0042 0.0018
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0131 0.0725 0.1161
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0673 0.1629
Loa Loa (eye worm) hypothetical protein 0.0125 0.0682 0.1152
Schistosoma mansoni ap endonuclease 0.004 0.0095 0.0072
Leishmania major pyruvate kinase 0.0038 0.0079 0.0129
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0053 0.0185 0.0143
Trypanosoma brucei DNA polymerase IV, putative 0.0122 0.0661 0.1498
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0053 0.0185 1
Echinococcus multilocularis serotonin receptor 0.03 0.1891 0.1872
Loa Loa (eye worm) hypothetical protein 0.0073 0.0323 0.0545
Giardia lamblia Pyruvate kinase 0.0038 0.0079 0.0134
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0601 0.1101
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0305 0.1925 0.4952
Loa Loa (eye worm) hypothetical protein 0.03 0.1891 0.3192
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0694 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0694 0.0671
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0131 0.0725 0.1363
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.032 0.0697
Mycobacterium tuberculosis Probable reductase 0.035 0.2235 0.4549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0673 0.1136
Mycobacterium tuberculosis Probable dehydrogenase 0.035 0.2235 0.4549
Brugia malayi phosphofructokinase 0.0124 0.0673 0.1072
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0205 0.1235 0.1198
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0096 0.0483 0.5382
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0205 0.1235 0.1214
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0096 0.0482 0.0814
Brugia malayi Disco-interacting protein 2 homolog 0.0044 0.0121 0.0134
Mycobacterium leprae Probable lipase LipE 0.0113 0.0601 0.2151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0096 0.0482 0.085
Trypanosoma cruzi trypanothione reductase, putative 0.0153 0.0878 0.2008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0053 0.0185 0.042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1669 0.1649
Schistosoma mansoni cpg binding protein 0.0038 0.0081 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Mycobacterium ulcerans DNA polymerase IV 0.0122 0.0661 0.1659
Onchocerca volvulus 0.0113 0.0601 0.078
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0091 0.0444 0.0989
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0037 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0601 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.0482 0.0748
Onchocerca volvulus 0.0038 0.0081 0.0004
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0635 0.0612
Plasmodium vivax SET domain protein, putative 0.0127 0.0694 0.7846
Trypanosoma brucei unspecified product 0.0115 0.0616 0.1394
Schistosoma mansoni transcription factor btf3 0.0035 0.006 0.0036
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0102 0.0526 0.1182
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0601 0.0837
Trypanosoma brucei DNA polymerase eta, putative 0.0125 0.0682 0.1549
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0601 0.1357
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0601 0.1101
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0102 0.0526 0.0944
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0053 0.0185 0.1887
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0389 0.2505 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0195 0.026
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0601 0.0837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0053 0.0185 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0694 0.0671
Treponema pallidum fructose-bisphosphate aldolase 0.0624 0.413 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0389 0.2505 0.5118
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0673 0.065
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0079 0.0062
Schistosoma mansoni pyruvate kinase 0.0038 0.0079 0.0055
Echinococcus multilocularis pyruvate kinase 0.0038 0.0079 0.0055
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0049 0.0018
Onchocerca volvulus 0.0044 0.0121 0.0063
Brugia malayi beta-lactamase 0.0113 0.0601 0.0949
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0134 0.0741 0.1869
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0635 0.0595
Echinococcus multilocularis thioredoxin glutathione reductase 0.0153 0.0878 0.0856
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0645 0.4274 1
Loa Loa (eye worm) glutathione reductase 0.0153 0.0878 0.1481
Echinococcus multilocularis muscleblind protein 1 0.0169 0.0987 0.0965
Schistosoma mansoni cpg binding protein 0.0038 0.0081 0.0058
Toxoplasma gondii NAC domain-containing protein 0.0035 0.006 0.0423
Mycobacterium ulcerans DNA polymerase IV 0.0122 0.0661 0.1659
Trypanosoma cruzi DNA polymerase eta, putative 0.0059 0.0224 0.0471
Brugia malayi Pre-SET motif family protein 0.0127 0.0694 0.1107
Schistosoma mansoni lipoxygenase 0.0083 0.0389 0.0366
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0725 0.0703
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0673 0.1629
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0323 0.0545
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0096 0.0482 0.0459
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0079 0.0062
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0673 0.065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0038 0.0081 0.0137
Brugia malayi 6-phosphofructokinase 0.0124 0.0673 0.1072
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0601 0.0561
Echinococcus multilocularis serotonin transporter 0.0073 0.0323 0.0299
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0053 0.0185 0.042
Mycobacterium ulcerans hypothetical protein 0.034 0.2165 0.5579
Leishmania major basic transcription factor 3a, putative 0.0035 0.006 0.0085
Mycobacterium tuberculosis Conserved protein 0.0113 0.0601 0.1101
Echinococcus granulosus dna polymerase kappa 0.0122 0.0661 0.0621
Echinococcus multilocularis microtubule associated protein 2 0.1473 1 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0987 0.1666
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0601 0.1101
Mycobacterium tuberculosis Conserved protein 0.0113 0.0601 0.1101
Echinococcus multilocularis dna polymerase eta 0.0125 0.0682 0.066
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.006 0.0085
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0673 0.0945
Entamoeba histolytica hypothetical protein 0.0035 0.006 0.0146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.035 0.2235 0.4549
Echinococcus granulosus cpg binding protein 0.0038 0.0081 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.006 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0601 0.0837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.035 0.2235 0.4549
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0723 0.4819 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0601 0.1101
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0095 0.0072
Echinococcus granulosus thioredoxin glutathione reductase 0.0153 0.0878 0.0839
Echinococcus granulosus serotonin transporter 0.0073 0.0323 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.032 0.0697
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0053 0.0185 0.0162
Brugia malayi glutaminase DH11.1 0.0585 0.3862 0.6494
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0673 0.0945
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.0185 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0673 0.0945
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0095 0.0161
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0601 0.0837
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0064 0.0261 0.0751
Entamoeba histolytica deoxycytidyl transferase, putative 0.0096 0.0482 0.1167
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0053 0.0185 0.1887
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0601 0.0578
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0725 0.1826
Loa Loa (eye worm) hypothetical protein 0.0056 0.0203 0.0342
Trichomonas vaginalis glutathione reductase, putative 0.0053 0.0185 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Mycobacterium ulcerans beta-lactamase 0.0113 0.0601 0.1503
Schistosoma mansoni terminal deoxycytidyl transferase 0.0096 0.0482 0.0459
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0673 0.1253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0079 0.0129
Brugia malayi hypothetical protein 0.0501 0.3285 0.5513
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0049 0.006
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.006 0.0085
Toxoplasma gondii hypothetical protein 0.0104 0.0537 0.6005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0122 0.0661 0.0622
Trypanosoma brucei DNA polymerase IV, putative 0.0122 0.0661 0.1498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0601 0.0578
Loa Loa (eye worm) hypothetical protein 0.0169 0.0987 0.1666
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0037 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0095 0.0168
Onchocerca volvulus 0.1005 0.6768 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0323 0.0477
Echinococcus multilocularis transcription factor btf3 0.0035 0.006 0.0036
Onchocerca volvulus 0.0073 0.0323 0.0364
Loa Loa (eye worm) hypothetical protein 0.0127 0.0694 0.1171
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0095 0.0186
Schistosoma mansoni lipoxygenase 0.0118 0.0635 0.0612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0601 0.0949
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0134 0.0741 0.1397
Brugia malayi ImpB/MucB/SamB family protein 0.0125 0.0682 0.1088
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0049 0.0291
Echinococcus granulosus disco interacting protein 2 0.0044 0.0121 0.0079
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0049 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0079 0.0133
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0053 0.0185 0.0224
Echinococcus multilocularis dna polymerase kappa 0.0122 0.0661 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Echinococcus granulosus pyruvate kinase 0.0038 0.0079 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.006 0.0034
Schistosoma mansoni glutaminase 0.0585 0.3862 0.3847
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0079 0.0644
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.0185 0.0379
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0079 0.0062
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0079 0.0129
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0039 0.0088 0.0077
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0673 0.1691
Echinococcus multilocularis serotonin receptor 0.03 0.1891 0.1872
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0049 0.0291
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1669 0.1633
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0131 0.0725 0.0703
Leishmania major DNA polymerase eta, putative 0.0125 0.0682 0.1549
Echinococcus multilocularis pyruvate kinase 0.0038 0.0079 0.0055
Brugia malayi beta-lactamase family protein 0.0113 0.0601 0.0949
Echinococcus granulosus transcription factor btf3 0.0035 0.006 0.0018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0053 0.0185 0.0392
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0079 0.0143
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0053 0.0185 0.0379
Loa Loa (eye worm) thioredoxin reductase 0.0153 0.0878 0.1481
Toxoplasma gondii thioredoxin reductase 0.0153 0.0878 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.035 0.2235 0.4549
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.0185 0.0379
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.0185 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0526 0.1182
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0096 0.0482 0.0442
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0673 0.1526
Brugia malayi Thioredoxin reductase 0.0153 0.0878 0.142
Echinococcus multilocularis transcription factor Dp 1 0.0119 0.0638 0.0616
Trichomonas vaginalis rotamase, putative 0.0032 0.0042 0.0008
Echinococcus granulosus dna polymerase eta 0.0125 0.0682 0.0643
Treponema pallidum NADH oxidase 0.0053 0.0185 0.0334
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0323 0.0299
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0053 0.0185 0.0379
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0305 0.1925 0.7608
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0095 0.0114
Brugia malayi Muscleblind-like protein 0.0169 0.0987 0.1606
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0205 0.1235 0.285
Trypanosoma brucei beta lactamase 0.0064 0.0261 0.0558
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0645 0.4274 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0095 0.0168
Echinococcus multilocularis expressed protein 0.0425 0.2754 0.2736
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0305 0.1927 0.4477
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0261 0.0384
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.006 0.0423
Schistosoma mansoni DNA polymerase eta 0.0125 0.0682 0.066
Plasmodium falciparum thioredoxin reductase 0.0153 0.0878 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0673 0.1136
Giardia lamblia Fructose-bisphosphate aldolase 0.0624 0.413 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0389 0.2505 0.5118
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0725 0.0686
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0205 0.1235 0.1214
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.0185 0.0379
Leishmania major hypothetical protein, conserved 0.0113 0.0601 0.1357
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0694 0.0671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0694 0.0671
Loa Loa (eye worm) hypothetical protein 0.0073 0.0323 0.0545
Trichomonas vaginalis mercuric reductase, putative 0.0053 0.0185 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0673 0.0945
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0053 0.0185 0.1887
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0725 0.1826
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0323 0.0545
Plasmodium falciparum thioredoxin reductase 0.0053 0.0185 0.1887
Echinococcus multilocularis expressed protein 0.0032 0.0042 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Toxoplasma gondii hypothetical protein 0.0096 0.0483 0.5382
Brugia malayi beta-lactamase family protein 0.0113 0.0601 0.0949
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0601 0.1101
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0095 0.0174
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0444 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Echinococcus multilocularis muscleblind protein 0.0169 0.0987 0.0965
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0037 0.009
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.006 0.0423
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0601 0.0837
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Onchocerca volvulus 0.0113 0.0601 0.078
Leishmania major pyruvate kinase 0.0038 0.0079 0.0129
Leishmania major DNA polymerase kappa, putative 0.0102 0.0526 0.1182
Giardia lamblia DINP protein human, muc B family 0.0102 0.0526 0.1223
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.1235 0.285
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0096 0.0482 0.0459
Mycobacterium ulcerans lipoprotein LpqF 0.0064 0.0261 0.0618
Loa Loa (eye worm) glutaminase 0.0585 0.3862 0.6519
Loa Loa (eye worm) glutaminase 2 0.0585 0.3862 0.6519
Onchocerca volvulus 0.0055 0.0195 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0203 0.042
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.1235 0.285
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0673 0.065
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0673 0.1629
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.006 0.0146
Echinococcus granulosus muscleblind protein 0.0169 0.0987 0.0949
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0091 0.0444 0.0989
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0601 0.1357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0122 0.0661 0.0927
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0601 0.1101
Loa Loa (eye worm) hypothetical protein 0.0044 0.0121 0.0204
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0079 0.0129
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0205 0.1235 0.2085
Trypanosoma brucei unspecified product 0.0066 0.0276 0.0593
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0673 0.1529
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0323 0.0671
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0673 0.0633
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Brugia malayi glutathione reductase 0.0153 0.0878 0.142
Onchocerca volvulus 0.0113 0.0601 0.078
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0079 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0323 0.0545
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0185 0.0379
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.035 0.2235 0.8888
Brugia malayi 6-phosphofructokinase 0.0124 0.0673 0.1072
Mycobacterium ulcerans glutaminase 0.0585 0.3862 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0323 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0305 0.1927 0.4477
Echinococcus granulosus pyruvate kinase 0.0038 0.0079 0.0037
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0305 0.1925 0.3893
Brugia malayi beta-NAC-like protein 0.0035 0.006 0.003
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0042 0.0071
Loa Loa (eye worm) hypothetical protein 0.0501 0.3285 0.5545
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0042 0.0008
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0049 0.0291
Schistosoma mansoni biogenic amine (5HT) receptor 0.03 0.1891 0.1871
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0694 0.0671
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0053 0.0185 0.1887
Schistosoma mansoni cpg binding protein 0.0038 0.0081 0.0058
Trichomonas vaginalis DNA polymerase eta, putative 0.0122 0.0661 0.0927
Leishmania major DNA polymerase eta, putative 0.0059 0.0224 0.0471
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0049 0.0018
Loa Loa (eye worm) ICD-1 protein 0.0035 0.006 0.0101
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0673 0.1526
Leishmania major mitochondrial DNA polymerase beta 0.0645 0.4274 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0095 0.0231
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0673 0.2448
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0095 0.0087
Brugia malayi Pre-SET motif family protein 0.0883 0.5924 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0133
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0053 0.0185 0.0379
Loa Loa (eye worm) hypothetical protein 0.0113 0.0601 0.1014
Schistosoma mansoni ap endonuclease 0.004 0.0095 0.0072
Trichomonas vaginalis set domain proteins, putative 0.1005 0.6768 1
Toxoplasma gondii ABC1 family protein 0.0113 0.0601 0.6756
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0037 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0661 0.1498
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.0607 0.1025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0095 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.0323 0.0545
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0095 0.0836
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0095 0.0168
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0079 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0389 0.2505 0.5118
Toxoplasma gondii exonuclease III APE 0.004 0.0095 0.0836
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0037 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.0185 0.0379
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.0185 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0079 0.0062
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0444 0.0989
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0039 0.0088 0.0077
Loa Loa (eye worm) hypothetical protein 0.03 0.1891 0.3192
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0131 0.0725 0.1649
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0053 0.0185 0.042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.413 0.6082
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0205 0.1235 0.2991
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0624 0.413 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0694 0.7846
Brugia malayi polk-prov protein 0.0056 0.0203 0.0273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0694 0.0671
Mycobacterium ulcerans lipase LipD 0.0113 0.0601 0.1503
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0601 0.1503
Echinococcus granulosus transcription factor Dp 1 0.0119 0.0638 0.0599
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0673 0.1136
Trichomonas vaginalis glutaminase, putative 0.0585 0.3862 0.5683

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.3 Antagonist activity at 5HT1A ChEMBL. 20133028
Ki (binding) = 350 nM Binding affinity towards Serotonin transporter from rat cortex measured using [3H]-paroxetine ChEMBL. 11462981
Ki (binding) = 350 nM Binding affinity towards Serotonin transporter from rat cortex measured using [3H]-paroxetine ChEMBL. 11462981
Ki (binding) > 5000 nM Binding affinity to 5-hydroxytryptamine 1A receptor (5-HT 1A receptor, serotonin receptor) from rat cortex using [3H]-8-OH-DPAT as radioligand ChEMBL. 11462981
Ki (binding) > 5000 nM Binding affinity to 5-hydroxytryptamine 1A receptor (5-HT 1A receptor, serotonin receptor) from rat cortex using [3H]-8-OH-DPAT as radioligand ChEMBL. 11462981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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