Detailed information for compound 261961

Basic information

Technical information
  • TDR Targets ID: 261961
  • Name: (E)-6-(5-chloro-2-hydroxy-6-methoxy-3-methoxy carbonylphenyl)-4-methylhex-4-enoic acid
  • MW: 342.771 | Formula: C16H19ClO6
  • H donors: 2 H acceptors: 4 LogP: 3.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc(Cl)c(c(c1O)C/C=C(/CCC(=O)O)\C)OC
  • InChi: 1S/C16H19ClO6/c1-9(5-7-13(18)19)4-6-10-14(20)11(16(21)23-3)8-12(17)15(10)22-2/h4,8,20H,5-7H2,1-3H3,(H,18,19)/b9-4+
  • InChiKey: FGWFMMRQFJMSSX-RUDMXATFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-6-(5-chloro-2-hydroxy-6-methoxy-3-methoxycarbonyl-phenyl)-4-methyl-hex-4-enoic acid
  • (E)-6-(5-chloro-2-hydroxy-6-methoxy-3-methoxycarbonylphenyl)-4-methyl-4-hexenoic acid
  • (E)-6-(3-carbomethoxy-5-chloro-2-hydroxy-6-methoxy-phenyl)-4-methyl-hex-4-enoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0016 0.005 0.0088
Leishmania major hypothetical protein, conserved 0.0037 0.0274 0.2622
Brugia malayi jmjC domain containing protein 0.0038 0.0293 0.0486
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0254 0.0407
Leishmania major metacaspase, putative 0.0046 0.0374 0.3715
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.12 0.1179
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0374 0.2217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Schistosoma mansoni kinase 0.0049 0.0407 0.1304
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0393 0.1127
Echinococcus multilocularis RUN 0.0022 0.0118 0.0093
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0275 0.0802
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0333 0.0937
Trypanosoma brucei poly(adp-ribose) polymerase 0.0154 0.1566 1
Echinococcus multilocularis acetylcholinesterase 0.0131 0.1316 0.1295
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0062 0.0066
Echinococcus granulosus Ankyrin 0.0014 0.0026 0.0002
Echinococcus multilocularis zinc finger protein 0.0019 0.008 0.0056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0275 0.0457
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2396 0.7515
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0154 0.1566 0.1545
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.092 0.3053
Trypanosoma brucei DNA repair protein, putative 0.0037 0.0274 0.1565
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Schistosoma mansoni lipoxygenase 0.0022 0.0118 0.0317
Brugia malayi follicle stimulating hormone receptor 0.0226 0.237 0.3931
Brugia malayi Troponin I 0.0107 0.105 0.1742
Loa Loa (eye worm) hypothetical protein 0.0051 0.0439 0.0729
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.0949 1
Giardia lamblia Methionine aminopeptidase 0.0046 0.0374 0.0576
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.004 0.0033
Schistosoma mansoni hypothetical protein 0.0042 0.034 0.1074
Brugia malayi hypothetical protein 0.0063 0.0571 0.0947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0275 0.0457
Entamoeba histolytica hypothetical protein 0.0072 0.0666 0.1997
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0049 0.0409 0.2445
Brugia malayi hypothetical protein 0.0064 0.0574 0.0953
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0275 0.0457
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0323 0.0904
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Schistosoma mansoni tsg101-related 0.0047 0.0394 0.1258
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0116 0.031
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0275 0.0457
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0275 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0275 0.0457
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0237 0.0213
Leishmania major glycosyl hydrolase-like protein 0.0015 0.004 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0306 0.0507
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0116 0.0242
Schistosoma mansoni nuclear receptor 0.0017 0.0062 0.0127
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0333 0.3268
Leishmania major DNA repair protein, putative 0.0037 0.0274 0.2622
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0561 0.0952
Brugia malayi Methionine aminopeptidase protein type I 0.0049 0.0409 0.0678
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0046 0.0374 0.2217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0062 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2501 0.4148
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0275 0.0251
Brugia malayi nuclear receptor NHR-88 0.0037 0.0275 0.0457
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0062 0.0103
Entamoeba histolytica hypothetical protein 0.0072 0.0666 0.1997
Echinococcus granulosus Smad4 0.0016 0.005 0.0046
Echinococcus granulosus smad 0.0016 0.005 0.0046
Brugia malayi hypothetical protein 0.0072 0.0666 0.1104
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0561 0.1831
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0332 0.0309
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0118 0.1948
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0317
Loa Loa (eye worm) hypothetical protein 0.0097 0.094 0.1559
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0275 0.0855
Brugia malayi initiation factor 2-associated protein. 0.0046 0.0374 0.062
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0118 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0634 0.2078
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0333 0.1951
Schistosoma mansoni troponin I 0.0107 0.105 0.3498
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0564 0.1672
Brugia malayi nuclear hormone receptor 0.0017 0.0062 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.092 0.1526
Onchocerca volvulus DNA ligase 3 homolog 0.0037 0.0274 0.0798
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.005 0.0025
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.034 0.0558
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0275 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Trypanosoma brucei metacaspase 0.0046 0.0374 0.2217
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0116 0.0091
Echinococcus granulosus caspase 3 0.0075 0.0698 0.1194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0275 0.0457
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0656 0.0633
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0118 0.0195
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0062 0.0066
Schistosoma mansoni poly [ADP-ribose] polymerase 0.028 0.2956 1
Brugia malayi SRC-1 0.0038 0.0289 0.048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.005 0.0082
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0289 0.0469
Echinococcus granulosus poly (ADP ribose) polymerase 0.0043 0.035 0.0578
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0293 0.0915
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0323 0.1883
Echinococcus granulosus zinc finger protein 0.0019 0.008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Brugia malayi hypothetical protein 0.0019 0.0085 0.0141
Echinococcus multilocularis troponin i 0.0107 0.105 0.1028
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0116 0.031
Brugia malayi nuclear hormone receptor 0.0037 0.0275 0.0457
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0374 0.1192
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0733 0.2418
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.005 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0275 0.0855
Brugia malayi Carboxylesterase family protein 0.0022 0.0116 0.0192
Brugia malayi Bromodomain containing protein 0.0037 0.028 0.0464
Schistosoma mansoni gliotactin 0.0022 0.0116 0.031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3175 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0053 0.0097
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0333 0.0937
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.092 0.0897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0323 0.0904
Onchocerca volvulus 0.0022 0.0116 0.0291
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0374 0.1067
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0323 0.0904
Schistosoma mansoni tsg101-related 0.0058 0.0511 0.1658
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0289 0.0265
Loa Loa (eye worm) DR-78 0.0017 0.0062 0.0103
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0203 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0275 0.0457
Brugia malayi Smad1 0.0016 0.005 0.0084
Echinococcus multilocularis caspase 3 0.0075 0.0698 0.0675
Loa Loa (eye worm) RNA binding protein 0.0069 0.0634 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0333 0.0553
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0085 0.006
Schistosoma mansoni tyrosine kinase 0.0038 0.0289 0.0903
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0371 0.0348
Schistosoma mansoni alpha glucosidase 0.0041 0.0323 0.1018
Brugia malayi Pre-SET motif family protein 0.0201 0.209 0.3467
Onchocerca volvulus Tankyrase homolog 0.0021 0.01 0.0242
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0062 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0374 0.1067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Brugia malayi hypothetical protein 0.0017 0.0062 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0118 0.0165
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0203 0.0607
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0117 0.0538
Brugia malayi jmjC domain containing protein 0.0098 0.0956 0.1587
Brugia malayi DnaJ domain containing protein 0.0063 0.0564 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0275 0.0445
Loa Loa (eye worm) troponin T 0.0063 0.0571 0.0947
Echinococcus granulosus caspase 2 0.0088 0.0842 0.145
Onchocerca volvulus 0.0022 0.0116 0.0291
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0053 0.0097
Trypanosoma brucei metacaspase MCA3 0.0046 0.0374 0.2217
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0393 0.1127
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.028 0.2956 0.9301
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.004 0.0066
Echinococcus multilocularis Ankyrin 0.0014 0.0026 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0275 0.0445
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0133 0.1334 0.4189
Brugia malayi Cell death protein 3 precursor 0.0088 0.0842 0.1397
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0275 0.0457
Onchocerca volvulus 0.0022 0.0118 0.0298
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0085 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0047 0.0083
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.1316 0.1295
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0025 0.000000075765
Schistosoma mansoni hypothetical protein 0.0072 0.0666 0.2187
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0237 0.0376
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0564 0.0956
Loa Loa (eye worm) carboxylesterase 0.0131 0.1316 0.2184
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0323 0.0529
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0062 0.0119
Schistosoma mansoni zinc finger protein 0.0019 0.008 0.0189
Trypanosoma cruzi metacaspase, putative 0.0046 0.0374 0.2217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.005 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Echinococcus granulosus jun protein 0.0081 0.0766 0.1315
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0037 0.0274 0.1565
Entamoeba histolytica hypothetical protein 0.0043 0.035 0.0992
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1906 0.1886
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0275 0.0251
Loa Loa (eye worm) hypothetical protein 0.0088 0.0842 0.1397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.019 0.0563
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0374 0.1079
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0766 0.0744
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0154 0.1566 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Brugia malayi nuclear receptor NHR-67 0.0017 0.0062 0.0103
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0275 0.0855
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0118 0.0093
Schistosoma mansoni hypothetical protein 0.0107 0.105 0.3498
Brugia malayi hypothetical protein 0.0022 0.0116 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0435 0.0721
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0025 0.000000039386
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0465
Echinococcus multilocularis neuropeptide s receptor 0.0525 0.5664 0.5654
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0323 0.091
Brugia malayi hypothetical protein 0.0042 0.034 0.0563
Brugia malayi hypothetical protein 0.0022 0.0118 0.0195
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0046 0.0374 0.2217
Brugia malayi TAR-binding protein 0.0069 0.0634 0.1051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0178 0.0272
Loa Loa (eye worm) hypothetical protein 0.0131 0.1316 0.2184
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0033 0.0233 0.0209
Trypanosoma brucei Metacaspase-4 0.0046 0.0374 0.2217
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Brugia malayi hypothetical protein 0.0017 0.0062 0.0103
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0062 0.0127
Brugia malayi Troponin T 0.0063 0.0571 0.0947
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0064 0.0579 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0275 0.0457
Entamoeba histolytica protein kinase, putative 0.003 0.0207 0.0533
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.092 0.2807
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0062 0.0037
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0116 0.031
Schistosoma mansoni nuclear receptor 0.0017 0.0062 0.0127
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0249 0.0225
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Brugia malayi Bromodomain containing protein 0.0072 0.0671 0.1113
Schistosoma mansoni smad 0.0016 0.005 0.0088
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1485 0.2113
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0041
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0298 0.0485
Onchocerca volvulus 0.0064 0.0574 0.1759
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0062 0.0103
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0154 0.1566 1
Echinococcus granulosus poly adp ribose polymerase 2 0.0154 0.1566 0.2734
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0956 0.1652
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0193
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0062 0.0066
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.0949 0.5969
Echinococcus granulosus GPCR family 2 0.0016 0.005 0.0044
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0249 0.0397
Loa Loa (eye worm) hypothetical protein 0.0045 0.0371 0.0616
Brugia malayi Tnks protein 0.0021 0.0101 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0435 0.0721
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Plasmodium vivax metacaspase 1, putative 0.0046 0.0374 0.9036
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1906 0.1886
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.237 0.3931
Loa Loa (eye worm) initiation factor 2-associated protein 0.0046 0.0374 0.062
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1485 0.2266
Loa Loa (eye worm) Smad1 0.0016 0.005 0.0084
Echinococcus multilocularis caspase 8 0.0046 0.0374 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2501 0.4148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0561 0.0738
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.057 0.616 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0112 0.0087
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0033 0.0233 0.0195
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0275 0.0445
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0275 0.0802
Schistosoma mansoni rab6-interacting 0.0022 0.0118 0.0317
Brugia malayi Troponin family protein 0.0107 0.105 0.1742
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0275 0.0457
Brugia malayi PHD-finger family protein 0.0024 0.0137 0.0227
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0275 0.0855
Echinococcus multilocularis tankyrase 0.0021 0.01 0.0076
Schistosoma mansoni troponin I 0.0107 0.105 0.3498
Trypanosoma brucei glucosidase, putative 0.0041 0.0323 0.1883
Schistosoma mansoni bromodomain containing protein 0.0061 0.0546 0.1778
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0332 0.0546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0561 0.0738
Loa Loa (eye worm) troponin I 0.0107 0.105 0.1742
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0062 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0275 0.0457
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0289 0.0469
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0275 0.0855
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.034 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0275 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0275 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0275 0.0457
Entamoeba histolytica zinc finger protein, putative 0.0021 0.01 0.0193
Echinococcus granulosus peregrin 0.0032 0.0228 0.036
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.004 0.0048
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0033 0.0233 0.5
Brugia malayi bZIP transcription factor family protein 0.0081 0.0766 0.1271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.005 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0333 0.1951
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Schistosoma mansoni troponin t invertebrate 0.0133 0.1334 0.4466
Brugia malayi Protein kinase domain containing protein 0.0015 0.0034 0.0056
Entamoeba histolytica protein kinase, putative 0.0098 0.0949 0.2899
Brugia malayi Bromodomain containing protein 0.0032 0.0228 0.0378
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.092 0.5779
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Loa Loa (eye worm) methionine aminopeptidase type I 0.0049 0.0409 0.0678
Brugia malayi nuclear receptor NHR-88 0.0017 0.0062 0.0103
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0053 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Brugia malayi protein-tyrosine kinase 0.0034 0.0249 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Loa Loa (eye worm) carboxylesterase 0.0022 0.0116 0.0192
Brugia malayi Troponin T 0.0063 0.0571 0.0947
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.1906 0.3163
Entamoeba histolytica hypothetical protein 0.0072 0.0666 0.1997
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0561 0.0538
Onchocerca volvulus 0.0022 0.0116 0.0291
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Schistosoma mansoni hypothetical protein 0.0063 0.0564 0.1839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0275 0.0457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.092 0.5779
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0082
Schistosoma mansoni hypothetical protein 0.002 0.0091 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0275 0.0855
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0564 0.0935
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0116 0.0161
Brugia malayi Carboxylesterase family protein 0.0022 0.0116 0.0192
Schistosoma mansoni hypothetical protein 0.0192 0.1988 0.6697
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.034 0.0563
Brugia malayi Carboxylesterase family protein 0.0022 0.0116 0.0192
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.011 0.1087 0.1803
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0062 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0275 0.0457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0374 0.1079
Plasmodium vivax methionine aminopeptidase 2, putative 0.0046 0.0374 0.9034
Trypanosoma brucei polo-like protein kinase 0.0095 0.092 0.5779
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0033 0.0233 0.0195
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0116 0.0161
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0207 0.0323
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0323 0.3155
Loa Loa (eye worm) TK protein kinase 0.0034 0.0249 0.0412
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0141
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0561 0.1831
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0333 0.0309
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0085 0.0141
Entamoeba histolytica hypothetical protein 0.0098 0.0949 0.2899
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0374 0.2217
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0842 0.2616
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0275 0.0251
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.1316 0.2184
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0049 0.0409 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0333 0.0439
Toxoplasma gondii methionine aminopeptidase 0.0049 0.0409 0.1194
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0063 0.0571 0.1747
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0193
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.006 0.0099
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0394 0.1129
Loa Loa (eye worm) hypothetical protein 0.0107 0.105 0.1742
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.005 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0323 0.0536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0275 0.0445
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0639 0.0616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Schistosoma mansoni hypothetical protein 0.0066 0.0599 0.1958
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0275 0.0251
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0203 0.0316
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0116 0.0091
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0634 0.0611
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0053 0.0029
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.004 0.0033
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0025 0.000000022267
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0275 0.0457
Onchocerca volvulus 0.0022 0.0116 0.0291
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0049 0.0409 0.4096
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0272 0.0248
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0249 0.0225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0275 0.0802
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0634 0.2078
Schistosoma mansoni jun-related protein 0.0066 0.0599 0.1958
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0118 0.1948
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0333 0.1053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0233 0.0711
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0275 0.0445
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0293 0.0486
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0289 0.0469
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0275 0.0457
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0561 0.0538
Mycobacterium ulcerans methionine aminopeptidase 0.0033 0.0233 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0275 0.0457
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0634 0.1051
Loa Loa (eye worm) hypothetical protein 0.0107 0.105 0.1742
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0195
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0062 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0293 0.0475
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0289 0.0469
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0062 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.092 0.1526
Loa Loa (eye worm) troponin 0.0063 0.0571 0.0947
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0323 0.1883
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0333 0.0547
Echinococcus multilocularis Smad4 0.0016 0.005 0.0026
Echinococcus granulosus geminin 0.0192 0.1988 0.3481
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.12 0.4011
Echinococcus multilocularis GPCR, family 2 0.0016 0.005 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0062 0.0127
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.12 0.4011
Echinococcus multilocularis jun protein 0.0081 0.0766 0.0744
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0634 0.2078
Loa Loa (eye worm) hypothetical protein 0.0097 0.094 0.1559
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0046 0.0374 0.1192
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0046 0.0374 0.1118
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0323 0.0904
Brugia malayi Carboxylesterase family protein 0.0131 0.1316 0.2184
Brugia malayi Uncoordinated protein 44 0.0014 0.0025 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.0937
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3175 1
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0374 0.9036
Echinococcus granulosus caspase 0.012 0.12 0.2085
Onchocerca volvulus 0.0297 0.315 1
Echinococcus granulosus carboxylesterase 5A 0.0131 0.1316 0.2291
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0374 0.1067
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0949 0.5969
Onchocerca volvulus 0.0042 0.034 0.1008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0062 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0371 0.1183
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0034
Brugia malayi Carboxylesterase family protein 0.0022 0.0116 0.0192
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0118 0.0093
Echinococcus granulosus dual specificity 0.0098 0.0949 0.1639
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0374 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.12 0.2085
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.005 0.0084
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0639 0.109
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0634 0.2078
Loa Loa (eye worm) carboxylesterase 0.0022 0.0116 0.0192
Brugia malayi MH1 domain containing protein 0.0016 0.005 0.0084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0666 0.0643
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Brugia malayi RNA binding protein 0.0069 0.0634 0.1051
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0409 0.2445
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0409 0.2445
Brugia malayi hypothetical protein 0.0019 0.0085 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0195
Brugia malayi MH2 domain containing protein 0.0016 0.005 0.0084
Schistosoma mansoni zinc finger protein 0.0015 0.0034 0.0034
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0062 0.0037
Plasmodium vivax hypothetical protein, conserved 0.003 0.0203 0.4298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus multilocularis caspase 2 0.0088 0.0842 0.082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0033 0.0233 0.0195
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0289 0.0265
Schistosoma mansoni rab6-interacting 0.0022 0.0118 0.0317
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0275 0.0855
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0049 0.0409 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0275 0.0251
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0062 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0016 0.005 0.0082
Schistosoma mansoni coup transcription factor 0.0037 0.0275 0.0855
Plasmodium falciparum phd finger protein, putative 0.003 0.0203 0.4298
Brugia malayi conserved hypotetical protein 0.0017 0.0062 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0275 0.0457
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.1316 0.4406
Loa Loa (eye worm) hypothetical protein 0.0558 0.6028 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Echinococcus granulosus poly (ADP ribose) polymerase 0.0043 0.035 0.0578
Schistosoma mansoni hypothetical protein 0.003 0.0203 0.0607
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0666 0.2187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.019 0.0563
Loa Loa (eye worm) TK protein kinase 0.003 0.0207 0.0343
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0289 0.0469
Loa Loa (eye worm) hypothetical protein 0.007 0.0639 0.106
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0323 0.0904
Onchocerca volvulus 0.0037 0.0275 0.0802
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0062 0.0103
Brugia malayi ecdysteroid receptor 0.0037 0.0275 0.0457
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0656 0.112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.019 0.047
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0116 0.0242
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0842 0.2789
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0154 0.1566 0.5258
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1485 0.2266
Brugia malayi ecdysone receptor 0.0017 0.0062 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0275 0.0457
Onchocerca volvulus 0.0229 0.2397 0.7592
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.005 0.0044
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0033 0.0233 0.5141
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0062 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0275 0.0457
Loa Loa (eye worm) hypothetical protein 0.0154 0.1566 0.2598
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0333 0.0547
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0949 0.5969
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0323 0.0536
Trypanosoma cruzi DNA repair protein, putative 0.0037 0.0274 0.1565
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0116 0.0091
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0025 0.0041
Brugia malayi nuclear receptor RXR 0.0019 0.0085 0.0141
Schistosoma mansoni Smad4 0.0016 0.005 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Leishmania major hypothetical protein, conserved 0.0022 0.0117 0.0902
Echinococcus granulosus neuropeptide receptor A26 0.0525 0.5664 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0508 0.0857
Brugia malayi small heat shock protein 0.0558 0.6028 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0254 0.023
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0323 0.0904
Echinococcus granulosus tankyrase 0.0021 0.01 0.0134
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0333 0.0309
Brugia malayi PHD-finger family protein 0.003 0.0203 0.0336
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0275 0.0855
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0371 0.0615
Schistosoma mansoni polycystin 1-related 0.0022 0.0118 0.0317
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0289 0.0265
Brugia malayi WGR domain containing protein 0.0154 0.1566 0.2598
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0323 0.0904
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0033 0.0233 0.5141
Plasmodium falciparum metacaspase-like protein 0.0046 0.0374 0.9036
Schistosoma mansoni troponin I 0.0107 0.105 0.3498
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0275 0.0855
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0133 0.1337 0.4478
Trypanosoma cruzi metacaspase, putative 0.0046 0.0374 0.2217
Brugia malayi hypothetical protein 0.0297 0.315 0.5226
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0956 0.0934
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Onchocerca volvulus 0.0022 0.0116 0.0291
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0634 0.1051
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0291 0.3077 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1316 0.2184
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0086
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.028 0.2956 0.2939
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0091 0.0151
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0374 0.2217
Echinococcus multilocularis methionyl aminopeptidase 2 0.0046 0.0374 0.035
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0766 0.1315
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.019 0.0165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0275 0.0855
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0233 0.0711
Onchocerca volvulus 0.0017 0.0062 0.0119
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0086
Toxoplasma gondii methionine aminopeptidase 0.0033 0.0233 0.0614
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0026 0.0004
Brugia malayi Troponin T 0.0063 0.0571 0.0947
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0203 0.0513
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0062 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Echinococcus granulosus tyrosine kinase 0.0034 0.0249 0.0397
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0561 0.0738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0553
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0435 0.0721
Echinococcus granulosus poly (ADP ribose) polymerase 0.0087 0.083 0.1427
Schistosoma mansoni smad1 5 8 and 0.0016 0.005 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0275 0.0457
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0275 0.0457
Schistosoma mansoni troponin I 0.0107 0.105 0.3498
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0561 0.0738
Entamoeba histolytica hypothetical protein 0.0072 0.0666 0.1997
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0289 0.0265
Echinococcus granulosus caspase 8 0.0046 0.0374 0.062
Brugia malayi WGR domain containing protein 0.028 0.2956 0.4904
Schistosoma mansoni loxhd1 0.0022 0.0118 0.0317
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.005 0.0026
Schistosoma mansoni alpha-glucosidase 0.0159 0.1623 0.5452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0043
Brugia malayi Death domain containing protein 0.0014 0.0025 0.0041
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0289 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0141
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0275 0.0251
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0112 0.0154
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0275 0.0251
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0275 0.0855
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0062 0.0037
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0062 0.0127
Schistosoma mansoni tsg101-related 0.0058 0.0511 0.1658
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0634 0.2078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0049 0.0409 0.2445
Brugia malayi steroid hormone receptor 0.0037 0.0275 0.0457
Onchocerca volvulus 0.0029 0.019 0.0528
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0062 0.0103
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0046 0.0374 0.1079
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Schistosoma mansoni alpha-glucosidase 0.0159 0.1623 0.5452
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0062 0.0119
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0323 0.0299
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.057 0.616 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Brugia malayi Carboxylesterase family protein 0.0131 0.1316 0.2184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0275 0.0251
Schistosoma mansoni hypothetical protein 0.0035 0.0257 0.0791
Brugia malayi hypothetical protein 0.0022 0.0118 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0949 0.3152
Giardia lamblia Kinase, PLK 0.0095 0.092 0.2412
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0333 0.0309
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0323 0.0904
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0333 0.0547
Loa Loa (eye worm) tnks protein 0.0021 0.0101 0.0168
Plasmodium falciparum metacaspase 1 0.0046 0.0374 0.9036
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0047 0.0083
Entamoeba histolytica methionine aminopeptidase, putative 0.0046 0.0374 0.1067
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0257 0.0426
Echinococcus multilocularis dual specificity 0.0098 0.0949 0.0926
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3175 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.1906 0.3337
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0374 0.1067
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.0457
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3175 1
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0203 0.0336
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.004 0.0033
Leishmania major hypothetical protein, conserved 0.0016 0.0047 0.0139
Onchocerca volvulus 0.0022 0.0118 0.0298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0293 0.0915
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0289 0.0265
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0374 0.2217
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0374 0.1079
Loa Loa (eye worm) SRC-1 0.0038 0.0289 0.048
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.005 0.0046
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0025 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0323 0.0904
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0062 0.0127
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0333 0.1951
Plasmodium vivax SET domain protein, putative 0.0029 0.019 0.3935
Brugia malayi tailless protein 0.0017 0.0062 0.0103
Echinococcus multilocularis neuroligin 0.0022 0.0116 0.0091
Brugia malayi Doublecortin family protein 0.0022 0.0118 0.0195
Brugia malayi MH1 domain containing protein 0.0016 0.005 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0336
Echinococcus multilocularis smad 0.0016 0.005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Onchocerca volvulus Alhambra homolog 0.003 0.0203 0.057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0508 0.0484
Brugia malayi Pre-SET motif family protein 0.0029 0.019 0.0314
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0374 0.2217
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0564 0.0541
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0112 0.0297
Brugia malayi nuclear receptor RXR 0.0017 0.0062 0.0103
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0289 0.0265
Schistosoma mansoni tyrosine kinase 0.0038 0.0289 0.0903
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0085 0.0107
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0133 0.1334 0.1312
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0289 0.0469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0192
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0116 0.031
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0207 0.0183
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.092 0.1587
Onchocerca volvulus Troponin I homolog 0.0107 0.105 0.3282
Onchocerca volvulus 0.0107 0.1048 0.3276
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.0949 0.2899
Brugia malayi MH2 domain containing protein 0.0238 0.2501 0.4148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0274 0.0455
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0333 0.0937
Schistosoma mansoni hypothetical protein 0.0192 0.1988 0.6697
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0118 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0193
Schistosoma mansoni lipoxygenase 0.0062 0.0561 0.1829
Trichomonas vaginalis hypothetical protein 0.0034 0.0245 0.0656
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0249 0.0397
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0374 0.0621
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.0949 0.1574
Echinococcus granulosus methionyl aminopeptidase 2 0.0046 0.0374 0.062
Echinococcus granulosus neuroligin 0.0022 0.0116 0.0161
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0249 0.0225
Loa Loa (eye worm) hypothetical protein 0.0297 0.315 0.5226
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0289 0.0469
Echinococcus granulosus WGR domain containing protein 0.0087 0.083 0.1427
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0289 0.0265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0435 0.0721
Brugia malayi MH2 domain containing protein 0.0016 0.005 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0371 0.1183
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0047 0.0083
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0275 0.0855
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0116 0.031
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.057 0.616 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.0426
Echinococcus multilocularis acetylcholinesterase 0.0131 0.1316 0.1295
Loa Loa (eye worm) hypothetical protein 0.0068 0.0625 0.1037
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0062 0.0103
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0037 0.0274 0.1565
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0323 0.0904
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.1906 0.3163
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0117 0.0538
Schistosoma mansoni tankyrase 0.0021 0.0101 0.0262
Echinococcus multilocularis neuropeptide receptor A26 0.0525 0.5664 0.5654
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0555 0.0921
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0012 0.0019
Trypanosoma cruzi metacaspase, putative 0.0046 0.0374 0.2217
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0118 0.0093
Schistosoma mansoni smad1 5 8 and 0.0016 0.005 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0085 0.0205
Echinococcus granulosus poly ADP ribose polymerase 1 0.028 0.2956 0.5198
Echinococcus granulosus poly (ADP ribose) polymerase 0.0043 0.035 0.0578
Echinococcus multilocularis peregrin 0.0032 0.0228 0.0204
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0275 0.0445
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.092 0.9682
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0103
Echinococcus granulosus RUN 0.0022 0.0118 0.0165
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0561 0.0951
Trypanosoma cruzi metacaspase, putative 0.0046 0.0374 0.2217
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.005 0.0088
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0049 0.0409 0.2445
Chlamydia trachomatis methionine aminopeptidase 0.0033 0.0233 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0571 0.0947
Echinococcus multilocularis geminin 0.0192 0.1988 0.1968
Echinococcus granulosus acetylcholinesterase 0.0131 0.1316 0.2291
Trypanosoma brucei metacaspase MCA2 0.0046 0.0374 0.2217
Loa Loa (eye worm) hypothetical protein 0.0079 0.0742 0.1231
Echinococcus granulosus oncosphere protein Tso22e 0.0133 0.1334 0.2321
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0374 0.1067
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0561 0.5763
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0062 0.0066
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0666 0.1137
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0049 0.0409 0.0385
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0323 0.0904
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0275 0.0445
Entamoeba histolytica protein kinase, putative 0.0098 0.0949 0.2899
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0634 0.1051
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0203 0.0513
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.092 0.2807
Schistosoma mansoni zinc finger protein 0.0017 0.0062 0.0127
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0116 0.0161
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0561 0.1697
Plasmodium falciparum methionine aminopeptidase 2 0.0046 0.0374 0.9034
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0049 0.0409 0.0682
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.209 0.3467
Leishmania major methionine aminopeptidase 2, putative 0.0046 0.0374 0.3714
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0033 0.0233 0.0614
Echinococcus granulosus tar DNA binding protein 0.0069 0.0634 0.108
Brugia malayi Protein kinase domain containing protein 0.0098 0.0949 0.1574
Loa Loa (eye worm) hypothetical protein 0.0213 0.222 0.3682
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.092 0.2864
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0289 0.0265
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0333 0.1053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0275 0.0445
Onchocerca volvulus 0.0017 0.0062 0.0119
Echinococcus granulosus troponin i 0.0107 0.105 0.1819
Echinococcus granulosus neuropeptide s receptor 0.0525 0.5664 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3175 1
Echinococcus multilocularis caspase 0.012 0.12 0.1179
Echinococcus granulosus acetylcholinesterase 0.0131 0.1316 0.2291
Schistosoma mansoni acetylcholinesterase 0.0022 0.0116 0.031
Brugia malayi hypothetical protein 0.007 0.0639 0.106

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 61 uM Inhibitory activity of compound against L1210 leukemia cells in tissue culture ChEMBL. 8568826
IC50 (functional) = 61 uM Inhibitory activity of compound against L1210 leukemia cells in tissue culture ChEMBL. 8568826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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