Detailed information for compound 282559

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 252.803 | Formula: C15H23ClN-
  • H donors: 0 H acceptors: 0 LogP: 4.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C1Cc2c(C1)cccc2)CCC.[Cl-]
  • InChi: 1S/C15H23N.ClH/c1-3-9-16(10-4-2)15-11-13-7-5-6-8-14(13)12-15;/h5-8,15H,3-4,9-12H2,1-2H3;1H/p-1
  • InChiKey: YLWMNERZFSQCIT-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia PHD finger protein 15 0.0058 0.0051 0.1032
Echinococcus granulosus GPCR family 2 0.0131 0.0178 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0315 0.0495 1
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0077 0.0069
Schistosoma mansoni patched 1 0.0041 0.0022 0.0019
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0077 0.0479
Trypanosoma brucei glucosidase, putative 0.0077 0.0084 0.1694
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0077 0.0076
Onchocerca volvulus 0.0073 0.0077 0.0524
Onchocerca volvulus 0.0073 0.0077 0.0524
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0691
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0049 0.0449
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0077 0.0076
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0077 0.0076
Leishmania major DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0212 0.0317 0.3929
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0077 0.0076
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0084 0.1702
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni survival motor neuron protein 0.0047 0.0032 0.0029
Loa Loa (eye worm) matrixin family protein 0.0958 0.1607 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0324 0.051 0.6429
Schistosoma mansoni phd/f-box containing protein 0.0082 0.0092 0.009
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0111 0.0143 0.2813
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0015 0.0088
Brugia malayi Matrixin family protein 0.0396 0.0636 0.3954
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0116 0.0108
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0427 0.0689 0.0688
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0133 0.26
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0024 0.0146
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0348 0.0552 0.3433
Brugia malayi hypothetical protein 0.0439 0.071 0.4415
Echinococcus granulosus microtubule associated protein 2 0.5735 0.9861 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0131 0.0178 0.0171
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0116 0.8415
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.0049 0.0988
Leishmania major hypothetical protein, conserved 0.0071 0.0074 0.1488
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0028 0.0027
Schistosoma mansoni amine GPCR 0.0073 0.0077 0.0075
Schistosoma mansoni neuropeptide receptor 0.0073 0.0077 0.0075
Onchocerca volvulus 0.0073 0.0077 0.0524
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0077 0.0075
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0315 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni pyruvate kinase 0.0037 0.0015 0.0011
Echinococcus granulosus mitogen activated protein kinase 0.0315 0.0495 0.0493
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0077 0.0479
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0024 0.0015
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0035 0.0679
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0082 0.0092 0.1812
Brugia malayi Bromodomain containing protein 0.0076 0.0082 0.051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.0156 0.0149
Schistosoma mansoni histamine h1 receptor 0.0073 0.0077 0.0075
Onchocerca volvulus 0.0073 0.0077 0.0524
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0055 0.0053
Echinococcus multilocularis neuropeptide receptor 0.0243 0.0371 0.037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0077 0.0479
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0077 0.0076
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0063 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0063 0.006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0348 0.0552 0.3433
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0024 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Onchocerca volvulus Alhambra homolog 0.0058 0.0051 0.0344
Leishmania major trypanothione reductase 0.014 0.0193 0.389
Mycobacterium tuberculosis Probable oxidoreductase 0.0355 0.0564 0.7134
Schistosoma mansoni jumonji domain containing protein 0.0388 0.0621 0.0627
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0063 0.0625
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.008 0.1605
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0035 0.0259
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0019 0.0018
Brugia malayi Serotonin receptor 0.0073 0.0077 0.0479
Plasmodium falciparum phd finger protein, putative 0.0058 0.0051 0.1001
Brugia malayi follicle stimulating hormone receptor 0.0303 0.0474 0.2948
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0315 0.0495 0.97
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0049 0.0048
Mycobacterium tuberculosis Conserved protein 0.0071 0.0074 0.077
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0239 0.0363 0.4527
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0024 0.0015
Schistosoma mansoni hypothetical protein 0.0073 0.0077 0.0075
Plasmodium falciparum JmjC domain-containing protein, putative 0.0082 0.0092 0.1812
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0028 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0035 0.0679
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0077 0.0479
Onchocerca volvulus 0.0042 0.0024 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0077 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus multilocularis mitogen activated protein kinase 3 0.0315 0.0495 0.0494
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0111 0.0143 0.1671
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0009 0.0008
Schistosoma mansoni biogenic amine receptor 0.0073 0.0077 0.0075
Schistosoma mansoni phosphatidylserine receptor 0.0082 0.0092 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0 0.001
Echinococcus granulosus neuropeptide receptor A26 0.1517 0.2573 0.2602
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0084 0.1651
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0072 0.1456
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0051 0.1001
Echinococcus granulosus serotonin receptor 0.0073 0.0077 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0077 0.0069
Onchocerca volvulus 0.015 0.021 0.1424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0106 0.0104
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0077 0.0075
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 0.6429
Echinococcus multilocularis expressed conserved protein 0.009 0.0106 0.0105
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0077 0.0075
Brugia malayi hypothetical protein 0.0042 0.0024 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0024 0.0015
Leishmania major pyruvate kinase 0.0037 0.0015 0.0287
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0063 0.0062
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0066 0.067
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0077 0.0069
Onchocerca volvulus Huntingtin homolog 0.0136 0.0185 0.1258
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.0193 0.389
Onchocerca volvulus 0.003 0.0003 0.0014
Toxoplasma gondii thioredoxin reductase 0.014 0.0193 0.378
Brugia malayi Thioredoxin reductase 0.014 0.0193 0.1197
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0024 0.0021
Echinococcus multilocularis jumonji domain containing 1A 0.0082 0.0092 0.0091
Brugia malayi beta-lactamase family protein 0.0071 0.0074 0.0458
Leishmania major hypothetical protein, conserved 0.003 0.0003 0.0059
Brugia malayi AKH receptor 0.0073 0.0077 0.0479
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0009 0.0006
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0077 0.0069
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus multilocularis tumor protein p63 0.0684 0.1133 0.1132
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0077 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0024 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Onchocerca volvulus Huntingtin homolog 0.0136 0.0185 0.1258
Schistosoma mansoni opsin-like receptor 0.0073 0.0077 0.0075
Echinococcus multilocularis mitogen activated protein kinase 0.0315 0.0495 0.0494
Brugia malayi Muscleblind-like protein 0.0145 0.0201 0.1248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0035 0.0691
Mycobacterium leprae Probable lipase LipE 0.0071 0.0074 0.077
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0015 0.0287
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0063 0.1261
Brugia malayi beta-lactamase family protein 0.0071 0.0074 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0077 0.0479
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0239 0.0363 0.0359
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0133 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0315 0.0495 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0133 0.0824
Loa Loa (eye worm) hypothetical protein 0.0131 0.0178 0.1103
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0066 0.067
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0084 0.1694
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0138 0.0136
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0077 0.0076
Onchocerca volvulus 0.0073 0.0077 0.0524
Trypanosoma brucei trypanothione reductase 0.014 0.0193 0.389
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0024 0.0159
Brugia malayi hypothetical protein 0.015 0.021 0.1303
Echinococcus granulosus tumor protein p63 0.0684 0.1133 0.1141
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis serotonin receptor 0.0073 0.0077 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0024 0.0146
Loa Loa (eye worm) hypothetical protein 0.0145 0.0201 0.1248
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0024 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0049 0.0988
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0015 0.0287
Entamoeba histolytica hypothetical protein 0.0108 0.0138 1
Onchocerca volvulus 0.0073 0.0077 0.0524
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0019 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0024 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0022 0.0438
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0231
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0049 0.0304
Brugia malayi ORL1-like opioid receptor 0.0073 0.0077 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0084 0.1702
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0077 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0315 0.0495 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0074 0.077
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0024 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0415 0.0668 0.4155
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0024 0.0146
Brugia malayi 6-phosphofructokinase 0.0105 0.0133 0.0824
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni rab6-interacting 0.004 0.0019 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0092 0.0572
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0239 0.0363 0.0365
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0077 0.0075
Leishmania major pyruvate kinase 0.0037 0.0015 0.0287
Schistosoma mansoni opsin-like receptor 0.0073 0.0077 0.0075
Echinococcus granulosus orexin receptor type 2 0.0073 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0084 0.1694
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.0193 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0074 0.0072
Brugia malayi jmjC domain containing protein 0.0082 0.0092 0.0572
Onchocerca volvulus 0.0071 0.0074 0.05
Schistosoma mansoni hypothetical protein 0.0042 0.0024 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0315 0.0495 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0024 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0106 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Brugia malayi nuclear hormone receptor 0.0042 0.0024 0.0146
Loa Loa (eye worm) runx1 0.0055 0.0046 0.0283
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Echinococcus multilocularis G protein coupled receptor 139 0.0243 0.0371 0.037
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0133 0.965
Trichomonas vaginalis CMGC family protein kinase 0.0315 0.0495 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0239 0.0363 0.0362
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0074 0.077
Brugia malayi phosphofructokinase 0.0105 0.0133 0.0824
Brugia malayi hypothetical protein 0.0108 0.0138 0.0854
Loa Loa (eye worm) hypothetical protein 0.0136 0.0185 0.1151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Schistosoma mansoni bromodomain containing protein 0.0126 0.0168 0.0167
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.0255 0.0253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0077 0.0076
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0019 0.0018
Brugia malayi Matrixin family protein 0.0396 0.0636 0.3954
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0024 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0284 0.0441 0.2743
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.0077 0.0076
Brugia malayi glutathione reductase 0.014 0.0193 0.1197
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0077 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Schistosoma mansoni zinc finger protein 0.0039 0.0018 0.0015
Brugia malayi putative neuropeptide receptor 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Leishmania major DNA polymerase eta, putative 0.0057 0.0049 0.0988
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0074 0.1488
Brugia malayi Melatonin receptor type 1A 0.0073 0.0077 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Schistosoma mansoni hypothetical protein 0.0131 0.0178 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0024 0.0023
Echinococcus multilocularis protein patched 0.0041 0.0022 0.002
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0187 0.018
Brugia malayi MAP kinase sur-1 0.0315 0.0495 0.3076
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0084 0.0076
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0074 0.1488
Echinococcus multilocularis peregrin 0.0063 0.0059 0.0058
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.0409 0.2544
Echinococcus multilocularis sex peptide receptor 0.0073 0.0077 0.0076
Onchocerca volvulus 0.0073 0.0077 0.0524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0106 0.0098
Onchocerca volvulus 0.0201 0.0299 0.2028
Schistosoma mansoni neuropeptide receptor 0.0073 0.0077 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Brugia malayi G protein-coupled receptor 0.0073 0.0077 0.0479
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Trypanosoma brucei unspecified product 0.0039 0.0019 0.0369
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0483 0.0785 0.4884
Loa Loa (eye worm) hypothetical protein 0.006 0.0055 0.0341
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0035 0.0679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0024 0.0146
Loa Loa (eye worm) beta-lactamase 0.0071 0.0074 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Brugia malayi GnHR receptor homolog 0.0073 0.0077 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0024 0.0146
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.008 0.1613
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0072 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Echinococcus granulosus g protein coupled receptor 0.0073 0.0077 0.0069
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0077 0.0069
Echinococcus multilocularis phd:f box containing protein 0.0082 0.0092 0.0091
Echinococcus multilocularis RUN 0.004 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0074 0.077
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0049 0.0449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0024 0.0146
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0315 0.0495 1
Onchocerca volvulus 0.0073 0.0077 0.0524
Schistosoma mansoni hypothetical protein 0.0131 0.0178 0.0177
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0015 0.0088
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.009 0.0089
Chlamydia trachomatis pyruvate kinase 0.0037 0.0015 0.0288
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0133 0.1534
Echinococcus granulosus JmjC domain containing protein 4 0.0082 0.0092 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0074 0.0072
Giardia lamblia Pyruvate kinase 0.0037 0.0015 0.0297
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0118
Onchocerca volvulus 0.0439 0.071 0.4827
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0049 0.0988
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0051 0.1001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Plasmodium vivax thioredoxin reductase, putative 0.014 0.0193 0.378
Schistosoma mansoni hypothetical protein 0.0296 0.0462 0.0465
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0077 0.0479
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0133 0.2687
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0077 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0084 0.1702
Echinococcus granulosus muscleblind protein 0.0145 0.0201 0.0195
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0077 0.0069
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0084 0.6114
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0077 0.0069
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0015 0.0088
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0077 0.0076
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0133 0.0125
Brugia malayi hypothetical protein 0.004 0.0019 0.0118
Plasmodium falciparum glutathione reductase 0.014 0.0193 0.378
Onchocerca volvulus 0.0073 0.0077 0.0524
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0133 0.0131
Loa Loa (eye worm) hypothetical protein 0.0136 0.0185 0.1151
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis Protein lozenge 0.0055 0.0046 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0082 0.0092 0.186
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0077 0.0076
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0077 0.0479
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0084 0.1702
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0077 0.0479
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0133 0.0131
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Onchocerca volvulus 0.0073 0.0077 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0024 0.0146
Brugia malayi ecdysteroid receptor 0.0042 0.0024 0.0146
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0049 0.0304
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0077 0.0075
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0077 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0024 0.0146
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0015 0.0288
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0063 0.0625
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.008 0.1605
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0088
Echinococcus granulosus pyruvate kinase 0.0037 0.0015 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0082 0.0092 0.0091
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi PHD-finger family protein 0.0058 0.0051 0.0315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0106 0.0098
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0086 0.0099 0.0098
Entamoeba histolytica hypothetical protein 0.0108 0.0138 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0024 0.0146
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0319 0.0503 0.6335
Plasmodium vivax JmjC domain containing protein 0.0082 0.0092 0.1812
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0012 0.0074
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0077 0.0075
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0133 0.0131
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0396 0.0636 0.3954
Onchocerca volvulus 0.0073 0.0077 0.0524
Leishmania major hypothetical protein, conserved 0.0082 0.0092 0.186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0063 0.0625
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0324 0.051 1
Toxoplasma gondii ABC1 family protein 0.0071 0.0074 0.1451
Loa Loa (eye worm) hypothetical protein 0.0396 0.0636 0.3954
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0427 0.0689 0.069
Brugia malayi RE15519p 0.0073 0.0077 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0035 0.0679
Mycobacterium tuberculosis Conserved protein 0.0071 0.0074 0.077
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Onchocerca volvulus 0.01 0.0124 0.084
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0035 0.0691
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Schistosoma mansoni alpha-glucosidase 0.0299 0.0468 0.0472
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0111 0.0143 0.2813
Brugia malayi Dopamine receptor protein 1 0.0073 0.0077 0.0479
Brugia malayi jmjC domain containing protein 0.0427 0.0689 0.4284
Giardia lamblia Kinase, CMGC MAPK 0.0315 0.0495 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0074 0.077
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0016
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0133 0.965
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0131 0.0178 0.0171
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0074 0.0066
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.008 0.0071
Schistosoma mansoni hypothetical protein 0.0058 0.0051 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0015 0.0097
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0133 0.0131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0009 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0024 0.0146
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0347 0.0343
Onchocerca volvulus 0.0073 0.0077 0.0524
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0019 0.0381
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0239 0.0363 0.7344
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0077 0.0076
Brugia malayi jmjC domain containing protein 0.0082 0.0092 0.0572
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Onchocerca volvulus Matrilysin homolog 0.0396 0.0636 0.4323
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0015 0.0287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0355 0.0564 0.7134
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0212 0.0317 0.3929
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Brugia malayi 6-phosphofructokinase 0.0105 0.0133 0.0824
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0015 0.0287
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0077 0.0479
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0015 0.0097
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0077 0.0479
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0074 0.1496
Schistosoma mansoni coup transcription factor 0.0042 0.0024 0.0021
Schistosoma mansoni lipoxygenase 0.0104 0.0131 0.013
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0133 0.2679
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0024 0.0023
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0051 0.0042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0049 0.358
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0012 0.0074
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0483 0.0785 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0022 0.002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0324 0.051 0.3171
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0077 0.0076
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0239 0.0363 0.4527
Echinococcus granulosus pyruvate kinase 0.0037 0.0015 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0051 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0074 0.077
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0024 0.0015
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0133 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0268 0.5413
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0077 0.0076
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0035 0.0691
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0133 0.1534
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0084 0.1702
Giardia lamblia DINP protein human, muc B family 0.0057 0.0049 0.0997
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0268 0.5413
Loa Loa (eye worm) hypothetical protein 0.0141 0.0194 0.1204
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0092 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0074 0.0073
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0032 0.0194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0415 0.0668 0.4155
Schistosoma mansoni hypothetical protein 0.0047 0.0032 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0084 0.0521
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0051 0.1001
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0077 0.0069
Echinococcus granulosus jumonji domain containing 1A 0.0082 0.0092 0.0084
Schistosoma mansoni myosin xvIII 0.0073 0.0077 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0074 0.0458
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0133 0.0131
Brugia malayi Doublecortin family protein 0.004 0.0019 0.0118
Echinococcus granulosus g protein coupled receptor 0.0073 0.0077 0.0069
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0009 0.0006
Trypanosoma brucei ISWI complex protein 0.003 0.0003 0.0059
Echinococcus granulosus geminin 0.0694 0.115 0.1158
Loa Loa (eye worm) jmjC domain-containing protein 0.0311 0.0488 0.3037
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0015 0.0288
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0131 0.0178 0.0177
Echinococcus granulosus g protein coupled receptor 0.0073 0.0077 0.0069
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0077 0.0069
Brugia malayi steroid hormone receptor 0.0042 0.0024 0.0146
Echinococcus granulosus fmrfamide receptor 0.0073 0.0077 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0024 0.0146
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0239 0.0363 0.4527
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0077 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0024 0.0146
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0131 0.0178 0.1103
Echinococcus multilocularis pyruvate kinase 0.0037 0.0015 0.0013
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0077 0.0075
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0015 0.0297
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0024 0.0021
Onchocerca volvulus 0.0073 0.0077 0.0524
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0049 0.0997
Brugia malayi beta-lactamase 0.0071 0.0074 0.0458
Echinococcus multilocularis peptidase Clp (S14 family) 0.0212 0.0317 0.0316
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0116 0.0718
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0032
Echinococcus granulosus zinc finger protein 0.0039 0.0018 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0024 0.0015
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0077 0.0076
Schistosoma mansoni biogenic amine receptor 0.0073 0.0077 0.0075
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1441 0.2442 0.2441
Brugia malayi Dopamine receptor protein 2 0.0073 0.0077 0.0479
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0049 0.0449
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0084 0.6114
Echinococcus granulosus neuropeptide receptor 0.0243 0.0371 0.0367
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0084 0.1702
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0082 0.0092 0.0572
Loa Loa (eye worm) hypothetical protein 0.0076 0.0083 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0151 0.0937
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0055 0.0373
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0015 0.0297
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0035 0.0679
Brugia malayi Dopamine receptor 0.0073 0.0077 0.0479
Onchocerca volvulus 0.0073 0.0077 0.0524
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0077 0.0076
Echinococcus multilocularis caspase 2 0.006 0.0055 0.0054
Brugia malayi G-protein coupled receptor 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0024 0.0021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0077 0.0069
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0012 0.0069
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 0.186
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0024 0.0146
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0118
Schistosoma mansoni loxhd1 0.004 0.0019 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0077 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0022 0.0132
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0315 0.0495 1
Brugia malayi jmjC domain containing protein 0.0311 0.0488 0.3037
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.0495 0.0498
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0035 0.0691
Echinococcus granulosus jumonji domain containing protein 0.0081 0.009 0.0082
Schistosoma mansoni amine GPCR 0.0073 0.0077 0.0075
Onchocerca volvulus 0.004 0.0019 0.0129
Brugia malayi Matrixin family protein 0.0396 0.0636 0.3954
Loa Loa (eye worm) hypothetical protein 0.0439 0.071 0.4415
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.0077 0.0524
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) latrophilin receptor protein 2 0.0131 0.0178 0.1103
Mycobacterium ulcerans lipase LipD 0.0071 0.0074 0.077
Onchocerca volvulus 0.0073 0.0077 0.0524
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Brugia malayi CHE-14 protein 0.0041 0.0022 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0132
Echinococcus granulosus neuropeptide receptor 0.0073 0.0077 0.0069
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0049 0.0449
Loa Loa (eye worm) hypothetical protein 0.01 0.0124 0.0768
Loa Loa (eye worm) hypothetical protein 0.0096 0.0116 0.0718
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0084 0.1702
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0035 0.07
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.008 0.1613
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0074 0.0066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0077 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0024 0.0023
Echinococcus multilocularis somatostatin receptor 0.0073 0.0077 0.0076
Schistosoma mansoni amine GPCR 0.0073 0.0077 0.0075
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0019 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0074 0.077
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0077 0.0075
Schistosoma mansoni DNA polymerase eta 0.0057 0.0049 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0077 0.0069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0024 0.0146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0106 0.0659
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0077 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0151 0.0937
Brugia malayi hypothetical protein 0.0136 0.0185 0.1151
Brugia malayi neuropeptide F receptor 0.0073 0.0077 0.0479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0024 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0015 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0024 0.0146
Trypanosoma brucei protein kinase, putative 0.0315 0.0495 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0015 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0077 0.0075
Schistosoma mansoni hypothetical protein 0.0284 0.0441 0.0444
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0015 0.0097
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0022 0.0132
Trypanosoma cruzi ISWI complex protein 0.003 0.0003 0.0059
Loa Loa (eye worm) inositol-1 0.0075 0.008 0.0494
Schistosoma mansoni alpha glucosidase 0.0077 0.0084 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0082 0.0092 0.009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0077 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0133 0.965
Echinococcus granulosus lysine specific demethylase 5A 0.0311 0.0488 0.0486
Trypanosoma brucei unspecified product 0.0039 0.0019 0.0369
Echinococcus multilocularis geminin 0.0694 0.115 0.1149
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0028 0.0025
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0133 0.0131
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0396 0.0636 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Onchocerca volvulus Matrilysin homolog 0.0879 0.147 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0049 0.0304
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0074 0.1496
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0 0.0036
Trichomonas vaginalis esterase, putative 0.0071 0.0074 0.1496
Brugia malayi G-protein coupled receptor 0.0073 0.0077 0.0479
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0 0.001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0024 0.0146
Onchocerca volvulus Matrix metalloproteinase homolog 0.0879 0.147 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0138 0.013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.008 0.5795
Loa Loa (eye worm) hypothetical protein 0.0145 0.0201 0.1248
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.0156 0.0155
Schistosoma mansoni amine GPCR 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0092 0.0572
Brugia malayi Melibiase family protein 0.007 0.0072 0.0445
Brugia malayi neuropeptide F receptor 0.0073 0.0077 0.0479
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0019 0.001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0118 0.0117
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0133 0.1534
Schistosoma mansoni microtubule-associated protein tau 0.5735 0.9861 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.008 0.0845
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0074 0.1488
Loa Loa (eye worm) matrix metalloproteinase 0.0396 0.0636 0.3954
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0074 0.077
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0063 0.1232
Schistosoma mansoni amine GPCR 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0284 0.0441 0.2743
Plasmodium falciparum thioredoxin reductase 0.014 0.0193 0.378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0106 0.0659
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0035 0.0691
Schistosoma mansoni hypothetical protein 0.0131 0.0178 0.0177
Schistosoma mansoni hypothetical protein 0.0108 0.0138 0.0136
Loa Loa (eye worm) hypothetical protein 0.0415 0.0668 0.4155
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0086 0.0099 0.0091
Schistosoma mansoni neuropeptide receptor 0.0243 0.0371 0.0373
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.0077 0.0069
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0315 0.0495 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0418 0.0674 0.068
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0084 0.1702
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni hypothetical protein 0.0694 0.115 0.1164
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1441 0.2442 0.2469
Onchocerca volvulus 0.0042 0.0024 0.0159
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0319 0.0503 0.6335
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0074 0.077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0009 0.0056
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0315 0.0495 0.3076
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0077 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0024 0.0021
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0324 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0232 0.144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0415 0.0668 0.4155
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0324 0.051 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Echinococcus granulosus phd:f box containing protein 0.0082 0.0092 0.0084
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0212 0.0317 0.3929
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0133 0.0131
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0259
Echinococcus granulosus peregrin 0.0063 0.0059 0.0051
Echinococcus multilocularis GPCR, family 2 0.0131 0.0178 0.0177
Echinococcus multilocularis lysosomal alpha glucosidase 0.0348 0.0552 0.0551
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0035 0.0691
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0024 0.0015
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0133 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Onchocerca volvulus 0.004 0.0019 0.0129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.008 0.1605
Echinococcus multilocularis muscleblind protein 0.0145 0.0201 0.02
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0077 0.0075
Brugia malayi hypothetical protein 0.004 0.0019 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0307 0.0482 0.0481
Echinococcus multilocularis protein dispatched 1 0.0047 0.0032 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0158 0.0979
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0 0.001
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0035 0.0259
Echinococcus multilocularis neuropeptide s receptor 0.1517 0.2573 0.2572
Echinococcus granulosus dna polymerase kappa 0.0057 0.0049 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0077 0.0075
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0133 0.2606
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0082 0.0092 0.186
Plasmodium falciparum thioredoxin reductase 0.0049 0.0035 0.0679
Onchocerca volvulus 0.0071 0.0074 0.05
Mycobacterium ulcerans hydrolase 0.0483 0.0785 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0074 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0077 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0063 0.0625
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0024 0.0015
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0077 0.0075
Schistosoma mansoni hypothetical protein 0.0131 0.0178 0.0177
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0133 0.0824
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0015 0.0088
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0124 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.0193 0.0186
Brugia malayi larval opioid receptor 0.0073 0.0077 0.0479
Echinococcus multilocularis zinc finger protein 0.0039 0.0018 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0311 0.0488 0.0492
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0024 0.0021
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0116 0.0115
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0035 0.0679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0009 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0133 0.2687
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi Hemopexin family protein 0.0562 0.0922 0.5736
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0077 0.0069
Echinococcus granulosus somatostatin receptor 0.0073 0.0077 0.0069
Toxoplasma gondii hypothetical protein 0.0111 0.0143 0.2813
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Echinococcus granulosus hypothetical protein 0.0073 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.0229 0.0347 0.2159
Brugia malayi jmjC domain containing protein 0.0082 0.0092 0.0572
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0035 0.07
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0019 0.0369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.5735 0.9861 0.9861
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0049 0.0047
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) thioredoxin reductase 0.014 0.0193 0.1197
Mycobacterium ulcerans hypothetical protein 0.0071 0.0074 0.077
Brugia malayi hypothetical protein 0.0073 0.0077 0.0479
Plasmodium falciparum glutathione reductase 0.0049 0.0035 0.0679
Schistosoma mansoni peptidase Clp (S14 family) 0.0324 0.051 0.0514
Onchocerca volvulus 0.0073 0.0077 0.0524
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0024 0.0146
Brugia malayi Matrixin family protein 0.0396 0.0636 0.3954
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.008 0.1565
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.0077 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0077 0.0069
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0082 0.0092 0.186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0 0.001
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.0255 0.0249
Echinococcus granulosus sex peptide receptor 0.0073 0.0077 0.0069
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0077 0.0069
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0252 0.1709
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0077 0.0076
Loa Loa (eye worm) doublecortin family protein 0.004 0.0019 0.0118
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0077 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0074 0.1451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0024 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.008 0.1613
Schistosoma mansoni hypothetical protein 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0252 0.5086
Schistosoma mansoni neuropeptide receptor 0.0073 0.0077 0.0075
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0022 0.0012
Brugia malayi hypothetical protein 0.0229 0.0347 0.2159
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0355 0.0564 0.7134
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0024 0.0146
Echinococcus granulosus lysosomal alpha glucosidase 0.0348 0.0552 0.0551
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0019 0.001
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0077 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0049 0.0988
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0024 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0024 0.0159
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0077 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0063 0.006
Loa Loa (eye worm) matrixin family protein 0.0879 0.147 0.9147
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0022 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0074 0.1496
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0239 0.0363 0.2259
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0035 0.07
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0077 0.0069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0077 0.0069
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0024 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0077 0.0076
Entamoeba histolytica hypothetical protein 0.0108 0.0138 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0074 0.1496
Trypanosoma cruzi ISWI complex protein 0.003 0.0003 0.0059
Echinococcus granulosus caspase 2 0.006 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0077 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0133 0.2687
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Mycobacterium tuberculosis Probable dehydrogenase 0.0319 0.0503 0.6335
Echinococcus granulosus neuropeptide s receptor 0.1517 0.2573 0.2602
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0409 0.8272
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0035 0.0679
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Brugia malayi jmjC domain containing protein 0.0082 0.0092 0.0572
Trypanosoma brucei unspecified product 0.0057 0.0049 0.0988
Loa Loa (eye worm) hypothetical protein 0.0058 0.0051 0.0315
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0082 0.0092 0.1812
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0303 0.0474 0.2948
Brugia malayi Cell death protein 3 precursor 0.006 0.0055 0.0341
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0077 0.0075
Echinococcus granulosus mitogen activated protein kinase 3 0.0315 0.0495 0.0493
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0077 0.0069
Mycobacterium ulcerans beta-lactamase 0.0071 0.0074 0.077
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0133 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Loa Loa (eye worm) hypothetical protein 0.015 0.021 0.1303
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0049 0.0047
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0319 0.0503 0.6335
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0016
Schistosoma mansoni protein phosphatase 2C 0.0082 0.0092 0.009
Loa Loa (eye worm) glutathione reductase 0.014 0.0193 0.1197
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.0193 0.2311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus granulosus dna polymerase eta 0.0057 0.0049 0.004
Schistosoma mansoni lipoxygenase 0.0176 0.0255 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0019 0.0369
Entamoeba histolytica hypothetical protein 0.0108 0.0138 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0138 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0074 0.077
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.008 0.1605
Plasmodium vivax glutathione reductase, putative 0.014 0.0193 0.378
Echinococcus multilocularis lysine specific demethylase 6a 0.0082 0.0092 0.0091
Echinococcus granulosus X box binding protein 1 0.0296 0.0462 0.046
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0049 0.0988
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0049 0.004
Onchocerca volvulus 0.0396 0.0636 0.4323
Mycobacterium tuberculosis Probable reductase 0.0319 0.0503 0.6335
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0201 0.02
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.0077 0.0524
Loa Loa (eye worm) hypothetical protein 0.007 0.0072 0.0445
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0319 0.0503 0.6335
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0216 0.0323 0.201
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0092 0.0572
Echinococcus multilocularis X box binding protein 1 0.0296 0.0462 0.0461
Echinococcus granulosus RUN 0.004 0.0019 0.001
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0133 0.2679
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0035 0.0213
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0035 0.0691
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0324 0.051 0.0508
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0084 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0024 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0084 0.1694
Brugia malayi Matrixin family protein 0.0958 0.1607 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0133 0.2687
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0319 0.0503 0.6335
Schistosoma mansoni hypothetical protein 0.0562 0.0922 0.0932
Brugia malayi nuclear receptor NHR-88 0.0042 0.0024 0.0146
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0092 0.0572
Brugia malayi Probable ClpP-like protease 0.0324 0.051 0.3171
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0187 0.0186
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0084 0.1702
Onchocerca volvulus 0.0047 0.0032 0.0212
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0111 0.0143 0.2813
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0347 0.0346
Echinococcus multilocularis dna polymerase eta 0.0057 0.0049 0.0048
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0077 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0024 0.0146
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0315 0.0495 1
Brugia malayi sulfakinin receptor protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0009 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0131 0.0178 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Schistosoma mansoni polycystin 1-related 0.0174 0.0251 0.0252
Plasmodium falciparum pyruvate kinase 0.0037 0.0015 0.0288
Echinococcus multilocularis serotonin receptor 0.0073 0.0077 0.0076
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.0738 0.9389
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0133 0.2679
Brugia malayi Inositol-1 0.0075 0.008 0.0494
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.0049 0.0988
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0035 0.0259
Loa Loa (eye worm) hypothetical protein 0.0396 0.0636 0.3954
Treponema pallidum NADH oxidase 0.0049 0.0035 0.0679
Schistosoma mansoni lozenge 0.0055 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Schistosoma mansoni biogenic amine receptor 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Mycobacterium leprae PROBABLE HYDROLASE 0.0483 0.0785 1
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0024 0.0146
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0324 0.051 0.0509
Loa Loa (eye worm) hypothetical protein 0.0057 0.0049 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0106 0.0104
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0074 0.077
Echinococcus granulosus expressed conserved protein 0.009 0.0106 0.0098
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0024 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0024 0.0146
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0077 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0071 0.0074 0.0458
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0077 0.0076
Echinococcus granulosus peptidase Clp S14 family 0.0212 0.0317 0.0313
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0077 0.0076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0074 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0049 0.0988
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0691
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0019 0.0381
Schistosoma mansoni hypothetical protein 0.0073 0.0077 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0077 0.0075
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0035 0.0026
Schistosoma mansoni opsin-like receptor 0.0073 0.0077 0.0075
Brugia malayi Latrophilin receptor protein 2 0.0131 0.0178 0.1103
Brugia malayi Bromodomain containing protein 0.0063 0.0059 0.0365
Schistosoma mansoni hypothetical protein 0.0694 0.115 0.1164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0077 0.0076
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.008 0.0177
Schistosoma mansoni rab6-interacting 0.004 0.0019 0.0016
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0084 0.0521
Echinococcus granulosus lysine specific demethylase 6a 0.0082 0.0092 0.0084
Schistosoma mansoni hypothetical protein 0.0073 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0035 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0019 0.0369
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0024 0.0015
Echinococcus granulosus allatostatin A receptor 0.0073 0.0077 0.0069
Schistosoma mansoni adenoreceptor 0.0073 0.0077 0.0075
Echinococcus multilocularis lysosomal alpha glucosidase 0.0348 0.0552 0.0551
Schistosoma mansoni inositol monophosphatase 0.0075 0.008 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.0085 0.0097 0.0603
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0315 0.0495 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0311 0.0488 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0106 0.0104
Onchocerca volvulus 0.0562 0.0922 0.6271
Schistosoma mansoni pyruvate kinase 0.0037 0.0015 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0077 0.0479
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0324 0.051 0.6429
Brugia malayi Bromodomain containing protein 0.0149 0.0209 0.1295
Loa Loa (eye worm) hypothetical protein 0.0483 0.0785 0.4884
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0072 0.007
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0077 0.0076
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0049 0.0997
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0077 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0074 0.1496
Loa Loa (eye worm) hypothetical protein 0.0439 0.071 0.4415
Onchocerca volvulus 0.0073 0.0077 0.0524
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0074 0.077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0077 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0041 0.0022 0.0019
Schistosoma mansoni alpha-glucosidase 0.0299 0.0468 0.0472
Loa Loa (eye worm) hypothetical protein 0.0081 0.0091 0.0562
Schistosoma mansoni inositol monophosphatase 0.0075 0.008 0.0078
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0355 0.0564 0.7134
Onchocerca volvulus 0.0071 0.0074 0.05
Brugia malayi PHD-finger family protein 0.005 0.0036 0.0224
Brugia malayi Serotonin receptor 0.0073 0.0077 0.0479
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0051 0.0315
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.0409 0.2544
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0077 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.1517 0.2573 0.2572
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0146
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479
Brugia malayi MH2 domain containing protein 0.0116 0.0151 0.0937
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0024 0.0021
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1528 0.2591 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0077 0.0479

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 22 Evaluated for analgesic activity and increase in reaction time in mouse by hot-plate assay ChEMBL. 7190613
Activity (functional) = 289 turns hr-1 Evaluated for induce circlingbehavior in the rat expressed as rotational behavior (turns/h) ChEMBL. 7190613
ED50 (functional) = 0.25 uM kg-1 Evaluated for inhibition of pressor response during central sciatic nerve stimulation in cat ChEMBL. 7190613
Reduction (functional) = 64 % Evaluated for drug-induced inhibition of exploratory activity in mouse ChEMBL. 7190613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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