Detailed information for compound 291258

Basic information

Technical information
  • TDR Targets ID: 291258
  • Name: (2R)-2-[[(2R)-2-[[(2S)-2,6-diacetamidohexanoy l]amino]propanoyl]amino]propanoic acid
  • MW: 372.417 | Formula: C16H28N4O6
  • H donors: 5 H acceptors: 6 LogP: -0.95 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)C)C)CCCCNC(=O)C
  • InChi: 1S/C16H28N4O6/c1-9(14(23)19-10(2)16(25)26)18-15(24)13(20-12(4)22)7-5-6-8-17-11(3)21/h9-10,13H,5-8H2,1-4H3,(H,17,21)(H,18,24)(H,19,23)(H,20,22)(H,25,26)/t9-,10-,13+/m1/s1
  • InChiKey: VIHGYLJIMMKSBR-BREBYQMCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-[[(2R)-2-[[(2S)-2,6-diacetamido-1-oxohexyl]amino]-1-oxopropyl]amino]propanoic acid
  • (2R)-2-[[(2R)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]propanoyl]amino]propionic acid
  • (Ac)2-L-Lys-D-Ala-D-Ala
  • (Ac)2-L-lysyl-D-alanyl-D-alanine
  • C03326

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0017 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0035
Brugia malayi ancient conserved domain protein 2 0.0019 0.0047 0.009
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.3255 1
Schistosoma mansoni zinc finger protein 0.0022 0.0078 0.0107
Onchocerca volvulus 0.0088 0.0755 0.2854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0174 0.0331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0174 0.0201
Schistosoma mansoni smad 0.0017 0.0022 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0077 0.0119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0174 0.0237
Loa Loa (eye worm) inositol-1 0.0038 0.0236 0.0449
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.2522 0.2921
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0204 0.0236
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0101 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Loa Loa (eye worm) chloride channel 3 0.0019 0.0047 0.009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0153 0.1434 0.1661
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0072 0.0137
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0434 0.0592
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0047 0.0105
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0164 0.019
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.027 0.0369
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0236 0.0273
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0236 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0174 0.0331
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0033 0.0038
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0224
Echinococcus multilocularis zinc finger protein 0.0022 0.0078 0.0091
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0022 0.0026
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0465 0.0885
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0077 0.003
Loa Loa (eye worm) hypothetical protein 0.0057 0.0434 0.0824
Schistosoma mansoni inositol monophosphatase 0.0038 0.0236 0.0322
Echinococcus granulosus histone acetyltransferase MYST2 0.0064 0.0515 0.0703
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0891 0.1216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0174 0.0331
Schistosoma mansoni jumonji domain containing protein 0.008 0.0676 0.0923
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1139 0.1556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0341 0.0647
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1201 0.1391
Onchocerca volvulus 0.0019 0.0047 0.0178
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0019 0.0047 0.0105
Mycobacterium ulcerans cystathionine beta-synthase 0.0019 0.0047 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0174 0.0331
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0174 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0174 0.0331
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.3255 1
Schistosoma mansoni survival motor neuron protein 0.0053 0.0391 0.0534
Leishmania major chloride channel protein, putative 0.0019 0.0047 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1434 0.5281
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.4974 0.6792
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.027 0.0369
Onchocerca volvulus Putative GMP reductase 0.0136 0.1262 0.4767
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0236 0.0589
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2949 0.9057
Mycobacterium tuberculosis Probable lipase LipD 0.0153 0.1434 0.1394
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0077 0.0089
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0174 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0174 0.0331
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0172 0.1635 0.4951
Brugia malayi PHD-finger family protein 0.0028 0.0137 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1139 0.3457
Brugia malayi CXXC zinc finger family protein 0.003 0.0159 0.0303
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0019 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0341 0.0394
Entamoeba histolytica hypothetical protein 0.0116 0.1047 1
Echinococcus multilocularis musashi 0.006 0.0465 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0204 0.0278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0021
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0019 0.0047 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0174 0.0237
Trichomonas vaginalis set domain proteins, putative 0.027 0.2647 1
Trypanosoma cruzi GMP reductase 0.0328 0.3255 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0174 0.0331
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0111 0.0152
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0153 0.1434 0.1394
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0047 0.0105
Schistosoma mansoni microtubule-associated protein tau 0.0719 0.7324 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0077 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0891 0.1032
Mycobacterium ulcerans esterase/lipase LipP 0.0153 0.1434 0.4369
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0214 0.0407
Echinococcus granulosus beta LACTamase domain containing family member 0.0153 0.1434 0.1958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0174 0.0331
Brugia malayi MH2 domain containing protein 0.0017 0.0022 0.0042
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0022 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0019 0.0025
Onchocerca volvulus 0.027 0.2647 1
Echinococcus multilocularis lamin 0.006 0.0465 0.0539
Schistosoma mansoni protein kinase subunit gamma 0.0019 0.0047 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0174 0.0237
Loa Loa (eye worm) hypothetical protein 0.0075 0.0624 0.1185
Mycobacterium ulcerans hypothetical protein 0.0019 0.0047 0.0079
Onchocerca volvulus 0.0153 0.1434 0.5418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0174 0.0331
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0019 0.0047 0.0063
Schistosoma mansoni smad1 5 8 and 0.0017 0.0022 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0174 0.0201
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0281 0.0827
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0174 0.0237
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0195 0.0149
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0101 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0164 0.0389
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0174 0.0201
Brugia malayi hypothetical protein 0.0017 0.0019 0.0035
Brugia malayi loechrig isoform VII 0.0019 0.0047 0.009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0022 0.003
Toxoplasma gondii exonuclease III APE 0.0022 0.0077 0.0093
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0019 0.0047 0.0065
Leishmania major chloride channel protein, putative 0.0019 0.0047 0.0105
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0174 0.0657
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0174 0.0237
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0047 0.0065
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0164 0.0364
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0755 0.0875
Onchocerca volvulus 0.006 0.0465 0.1759
Loa Loa (eye worm) hypothetical protein 0.0059 0.0454 0.0863
Brugia malayi steroid hormone receptor 0.0032 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0349 0.3472 0.4741
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0064 0.0515 0.0597
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0341 0.0647
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0018
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0174 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0174 0.0331
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.024 0.0328
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0022 0.0042
Echinococcus granulosus H:Cl exchange transporter 3 0.0019 0.0047 0.0065
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1139 0.1556
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0341 0.0465
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0521 0.526 1
Onchocerca volvulus 0.0153 0.1434 0.5418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0174 0.0331
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1139 0.3474
Brugia malayi N-terminal motif family protein 0.0188 0.1801 0.3424
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.0218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0174 0.0237
Loa Loa (eye worm) hypothetical protein 0.0047 0.0332 0.0632
Schistosoma mansoni lamin 0.006 0.0465 0.0636
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0377 0.1121
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Schistosoma mansoni intermediate filament proteins 0.006 0.0465 0.0636
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0064 0.0515 0.0703
Brugia malayi follicle stimulating hormone receptor 0.0521 0.526 1
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0079 0.0151
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0018
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0755 0.1031
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0174 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0174 0.0657
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0101 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0281 0.0827
Schistosoma mansoni chloride channel protein 0.0019 0.0047 0.0065
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0164 0.0364
Loa Loa (eye worm) hypothetical protein 0.0257 0.2522 0.4794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0341 0.0465
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0236 0.0663
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0164 0.0224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0035
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0172 0.1635 0.1595
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0174 0.0331
Trypanosoma brucei RNA helicase, putative 0.0532 0.538 1
Echinococcus granulosus peregrin 0.0033 0.019 0.026
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0111 0.0129
Plasmodium vivax hypothetical protein, conserved 0.0153 0.1434 0.4562
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0116 0.1047 0.143
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0328 0.3255 1
Schistosoma mansoni hypothetical protein 0.0022 0.0072 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0174 0.0201
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0019 0.0047 0.0055
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0525 0.0717
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.0018
Leishmania major guanosine monophosphate reductase 0.0328 0.3255 1
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0047 0.0105
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0195 0.0461
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0504 0.0958
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0236 0.0589
Mycobacterium tuberculosis Probable hydrolase 0.0153 0.1434 0.1394
Onchocerca volvulus 0.0035 0.0204 0.077
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0164 0.0224
Schistosoma mansoni chloride channel protein 0.0019 0.0047 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0392 0.0535
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0022 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0174 0.0331
Toxoplasma gondii hypothetical protein 0.0048 0.0345 0.093
Echinococcus multilocularis histone acetyltransferase MYST2 0.0064 0.0515 0.0597
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.1434 0.2648
Brugia malayi PHD-finger family protein 0.0031 0.0164 0.0312
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0021
Brugia malayi jmjC domain containing protein 0.0101 0.0891 0.1693
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0019 0.0025
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0019 0.0047 0.0055
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0153 0.1434 0.4369
Brugia malayi Bromodomain containing protein 0.0033 0.019 0.0361
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0236 0.0619
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0174 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0341 0.0465
Brugia malayi ancient conserved domain protein 4 0.0019 0.0047 0.009
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0328 0.3255 0.3223
Schistosoma mansoni Smad4 0.0017 0.0022 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0231 0.0268
Loa Loa (eye worm) hypothetical protein 0.0052 0.0385 0.0732
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.8633 1
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0022 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0719 0.7324 1
Brugia malayi nuclear hormone receptor 0.0032 0.0174 0.0331
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0184 0.0251
Loa Loa (eye worm) hypothetical protein 0.0043 0.0293 0.0558
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0064 0.0515 0.0979
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0077 0.0093
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0033 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0101 0.0163
Brugia malayi Bromodomain containing protein 0.0041 0.0267 0.0507
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.1047 0.143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0174 0.0331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1139 0.3457
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0236 0.1639
Entamoeba histolytica hypothetical protein 0.0116 0.1047 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0328 0.3255 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0136 0.1262 0.2399
Brugia malayi nuclear receptor RXR 0.0017 0.0019 0.0035
Loa Loa (eye worm) IMP dehydrogenase 1 0.0328 0.3255 0.6187
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0033 0.0044
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0385 0.0732
Loa Loa (eye worm) loechrig isoform VII 0.0019 0.0047 0.009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1314 0.4013
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0101 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0391 0.0743
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0174 0.0237
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0236 0.0687
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.0407
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0174 0.0237
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0174 0.0201
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.153 0.1772
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0035
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0308 0.3052 1
Brugia malayi Inositol-1 0.0038 0.0236 0.0449
Echinococcus granulosus lamin 0.006 0.0465 0.0636
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.1801 0.6805
Mycobacterium ulcerans hypothetical protein 0.0153 0.1434 0.4369
Mycobacterium tuberculosis Conserved protein 0.0153 0.1434 0.1394
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.2949 0.9057
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0156 0.1464 0.4418
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Brugia malayi Bromodomain containing protein 0.0081 0.0689 0.1309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0385 0.0732
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0385 0.0732
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0236 0.0687
Schistosoma mansoni inositol monophosphatase 0.0038 0.0236 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0164 0.0293
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0077 0.0197
Loa Loa (eye worm) hypothetical protein 0.0053 0.0392 0.0745
Schistosoma mansoni hypothetical protein 0.013 0.1201 0.164
Loa Loa (eye worm) GMP reductase 0.0136 0.1262 0.2399
Loa Loa (eye worm) chloride channel protein 7 0.0019 0.0047 0.009
Echinococcus granulosus dnaJ subfamily B 0.0431 0.4325 0.5905
Trypanosoma brucei GMP reductase 0.0328 0.3255 0.604
Mycobacterium tuberculosis Conserved protein 0.0153 0.1434 0.1394
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0105
Brugia malayi MH2 domain containing protein 0.0017 0.0022 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0144 0.0197
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0174 0.0201
Brugia malayi hypothetical protein 0.0017 0.0019 0.0035
Brugia malayi jmjC domain containing protein 0.0041 0.027 0.0514
Echinococcus multilocularis Smad4 0.0017 0.0022 0.0025
Entamoeba histolytica hypothetical protein 0.0025 0.0101 0.0247
Mycobacterium ulcerans beta-lactamase 0.0153 0.1434 0.4369
Echinococcus multilocularis microtubule associated protein 2 0.0719 0.7324 0.8483
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0174 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0019 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0174 0.0331
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0021
Brugia malayi Pre-SET motif family protein 0.0035 0.0204 0.0388
Brugia malayi CLC chloride channel protein 0.0019 0.0047 0.009
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0434 0.0502
Echinococcus granulosus zinc finger protein 0.0022 0.0078 0.0107
Mycobacterium ulcerans hypothetical protein 0.0157 0.148 0.451
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0077 0.0197
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0434 0.0592
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0274
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0174 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1434 0.4384
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0174 0.0331
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.2949 0.5471
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1139 0.3405
Echinococcus granulosus smad 0.0017 0.0022 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0022 0.0041
Onchocerca volvulus 0.0057 0.0434 0.1638
Onchocerca volvulus 0.006 0.0465 0.1759
Schistosoma mansoni chloride channel protein 0.0019 0.0047 0.0065
Echinococcus granulosus cpg binding protein 0.0034 0.0198 0.0271
Brugia malayi beta-lactamase family protein 0.0153 0.1434 0.2727
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.4325 0.501
Schistosoma mansoni coup transcription factor 0.0032 0.0174 0.0237
Mycobacterium tuberculosis Probable lipase LipE 0.0153 0.1434 0.1394
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0153 0.1434 0.2727
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0077 0.554
Leishmania major cytochrome p450-like protein 0.0017 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.009
Brugia malayi Cytochrome P450 family protein 0.0028 0.0137 0.0261
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.048 0.1348
Onchocerca volvulus Alhambra homolog 0.0031 0.0164 0.062
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0101 0.0167
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0101 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0174 0.0331
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.1047 0.143
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0174 0.0237
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0236 0.0322
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0019 0.0047 0.0065
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0101 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0312
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0328 0.3255 0.377
Brugia malayi MH2 domain containing protein 0.025 0.2446 0.4649
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1434 0.5281
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0077 0.0146
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0434 0.0824
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0144 0.0167
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.1047 0.1213
Trypanosoma cruzi GMP reductase 0.0328 0.3255 1
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0434 0.0592
Leishmania major CBS domain protein, conserved 0.0019 0.0047 0.0105
Schistosoma mansoni hypothetical protein 0.0431 0.4325 0.5905
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1314 0.2424
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0392 0.0535
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0308 0.3052 1
Schistosoma mansoni hypothetical protein 0.0036 0.0214 0.0292
Loa Loa (eye worm) intermediate filament protein 0.006 0.0465 0.0885
Mycobacterium ulcerans lipase LipD 0.0153 0.1434 0.4369
Toxoplasma gondii IMP dehydrogenas 0.0328 0.3255 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0047 0.0065
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0174 0.0331
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0077 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1139 0.1556
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0236 0.0619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0021
Schistosoma mansoni hypothetical protein 0.0532 0.538 0.7346
Brugia malayi beta-lactamase family protein 0.0153 0.1434 0.2727
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0174 0.0201
Brugia malayi ecdysteroid receptor 0.0032 0.0174 0.0331
Echinococcus granulosus Smad4 0.0017 0.0022 0.003
Brugia malayi intermediate filament protein 0.006 0.0465 0.0885
Schistosoma mansoni hypothetical protein 0.0192 0.1843 0.2517
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0047 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.004 0.0055
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0755 0.1031
Brugia malayi MH1 domain containing protein 0.0017 0.0022 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.052 0.071
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0236 0.0415
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0328 0.3255 0.4444
Onchocerca volvulus 0.0032 0.0174 0.0657
Brugia malayi CBS domain containing protein 0.0019 0.0047 0.009
Echinococcus granulosus H:Cl exchange transporter 7 0.0019 0.0047 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1434 0.1958
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0236 0.0619
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0328 0.3255 0.4444
Loa Loa (eye worm) hypothetical protein 0.0028 0.0133 0.0253
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0101 0.0178
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0289 0.0395
Mycobacterium ulcerans hypothetical protein 0.0019 0.0047 0.0079
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0434 0.1638
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0328 0.3255 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1314 0.4013
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0101 0.0167
Brugia malayi mbt repeat family protein 0.0057 0.0434 0.0824
Brugia malayi GMP reductase 0.0136 0.1262 0.2399
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0755 0.1436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.027 0.0369
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0174 0.0237
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0159 0.0303
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0022 0.0042
Giardia lamblia PHD finger protein 15 0.0031 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.009
Brugia malayi Voltage gated chloride channel family protein 0.0019 0.0047 0.009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0389 0.074
Onchocerca volvulus 0.0153 0.1434 0.5418
Echinococcus granulosus lamin dm0 0.006 0.0465 0.0636
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.2446 0.4649
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0228 0.2212 0.3021
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0019 0.0047 0.0055
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0101 0.0245
Trichomonas vaginalis esterase, putative 0.0153 0.1434 0.5281
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0019 0.0047 0.0055
Leishmania major inosine-5-monophosphate dehydrogenase 0.0328 0.3255 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.148 0.144
Echinococcus multilocularis geminin 0.0192 0.1843 0.2135
Brugia malayi hypothetical protein 0.0116 0.1047 0.1991
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0064 0.0515 0.0979
Brugia malayi Smad1 0.0017 0.0022 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0341 0.0394
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.027 0.0514
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.3255 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0022 0.003
Schistosoma mansoni hypothetical protein 0.0192 0.1843 0.2517
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.003
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.4974 0.5762
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0022 0.0041
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0164 0.0312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0281 0.0827
Brugia malayi nuclear receptor NHR-88 0.0032 0.0174 0.0331
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1139 0.132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0153 0.1434 0.1394
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0204 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1434 0.1958
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0156 0.1464 0.4462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.052 0.0603
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1139 0.3457
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0177 0.0337
Echinococcus multilocularis tumor protein p63 0.0358 0.3566 0.413
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0434 0.0592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0341 0.0465
Echinococcus granulosus intermediate filament protein 0.006 0.0465 0.0636
Schistosoma mansoni ap endonuclease 0.0022 0.0077 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0174 0.0331
Brugia malayi Pre-SET motif family protein 0.0237 0.2308 0.4387
Mycobacterium ulcerans hypothetical protein 0.0019 0.0047 0.0079
Mycobacterium tuberculosis Conserved protein 0.0153 0.1434 0.1394
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.009
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0047 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0392 0.0454
Mycobacterium leprae conserved hypothetical protein 0.0153 0.1434 0.4324
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0174 0.0237
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.4974 0.5762
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1434 0.5281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0392 0.0535
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0019 0.0035
Brugia malayi hypothetical protein 0.0257 0.2522 0.4794
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0047 0.0105
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0101 0.008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1139 0.1097
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0022 0.003
Toxoplasma gondii ABC1 family protein 0.0153 0.1434 0.4324
Schistosoma mansoni thyroid hormone receptor 0.0162 0.153 0.2089
Onchocerca volvulus 0.0052 0.0389 0.1471
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0331
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0289 0.0335
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0019 0.0025
Echinococcus granulosus tumor protein p63 0.0358 0.3566 0.4869
Onchocerca volvulus 0.003 0.0159 0.0602
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0136 0.1262 0.2399
Loa Loa (eye worm) hypothetical protein 0.0188 0.1801 0.3424
Onchocerca volvulus 0.0053 0.0391 0.1476
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0088 0.0755 0.1436
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1434 0.5281
Loa Loa (eye worm) MBCTL1 0.0064 0.0515 0.0979
Echinococcus granulosus geminin 0.0192 0.1843 0.2517
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.024 0.0279
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0019 0.0047 0.0055
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.2522 0.3443
Schistosoma mansoni hypothetical protein 0.0053 0.0391 0.0534
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0022 0.0025
Mycobacterium tuberculosis Probable esterase LipL 0.0153 0.1434 0.1394
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0328 0.3255 0.604
Echinococcus multilocularis cpg binding protein 0.0034 0.0198 0.023
Mycobacterium ulcerans transcriptional regulator 0.0019 0.0047 0.0079
Echinococcus granulosus neuropeptide s receptor 0.0493 0.4974 0.6792
Echinococcus multilocularis smad 0.0017 0.0022 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0077 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1434 0.5281
Loa Loa (eye worm) hypothetical protein 0.0153 0.1434 0.2727
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0111 0.0152
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0019 0.0047 0.0065
Echinococcus multilocularis lamin dm0 0.006 0.0465 0.0539
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1201 0.164
Entamoeba histolytica hypothetical protein 0.0116 0.1047 1
Schistosoma mansoni cpg binding protein 0.0034 0.0198 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0077 0.0197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0204 0.0488
Loa Loa (eye worm) hypothetical protein 0.0028 0.0133 0.0253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.009
Schistosoma mansoni bromodomain containing protein 0.0069 0.056 0.0764
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0047 0.0105
Loa Loa (eye worm) Smad1 0.0017 0.0022 0.0042
Entamoeba histolytica hypothetical protein 0.0116 0.1047 1
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0465 0.0885
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0077 0.0146
Brugia malayi chloride channel protein 7 0.0019 0.0047 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0174 0.0331
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0434 0.0502
Mycobacterium leprae Probable lipase LipE 0.0153 0.1434 0.4324
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0228 0.2212 0.2563
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0077 0.2543
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.003
Brugia malayi Cytochrome P450 family protein 0.0017 0.0022 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0137 0.0261
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0281 0.0499
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0153 0.1434 0.1394
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0174 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0341 0.0465
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1434 0.4384
Schistosoma mansoni ap endonuclease 0.0022 0.0077 0.0105
Leishmania major hypothetical protein, conserved 0.0153 0.1434 0.4384
Echinococcus multilocularis peregrin 0.0033 0.019 0.022
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0389 0.0532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0174 0.0237
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0047 0.0065
Loa Loa (eye worm) hypothetical protein 0.006 0.0465 0.0885
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0328 0.3255 0.6187
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0174 0.0657
Brugia malayi MH1 domain containing protein 0.0017 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0508
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0021
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0308 0.3052 0.9374
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.2446 0.4649
Brugia malayi mbt repeat family protein 0.0057 0.0434 0.0824
Loa Loa (eye worm) beta-lactamase 0.0153 0.1434 0.2727
Loa Loa (eye worm) hypothetical protein 0.0053 0.0392 0.0746
Plasmodium vivax SET domain protein, putative 0.0035 0.0204 0.0427
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0153 0.1434 0.2727
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0174 0.0237
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0177 0.0337
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0033 0.0044
Schistosoma mansoni myelin transcription factor 1 myt1 0.0064 0.0515 0.0703
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0039 0.0075
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0434 0.0592
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0101 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2949 0.9057
Brugia malayi beta-lactamase 0.0153 0.1434 0.2727
Schistosoma mansoni lamin 0.006 0.0465 0.0636
Brugia malayi Cytochrome P450 family protein 0.0017 0.0022 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0022 0.003
Schistosoma mansoni cpg binding protein 0.0034 0.0198 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0019 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.2308 0.4387
Schistosoma mansoni thyroid hormone receptor 0.0162 0.153 0.2089
Echinococcus granulosus H:Cl exchange transporter 4 0.0019 0.0047 0.0065

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 13 mM inhibitory activity of compound using pentapeptide cell-wall peptidoglycan (PG) substrates ChEMBL. 11958980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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