TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 846.962 | Formula: C45H58N4O12
H donors: 4 H acceptors: 6 LogP: 3.96 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CO[C@H]1C[C@H](C)CC2=C(NCCCCOc3ccc4c(c3)oc(cc4=O)N3CCOCC3)C(=O)C=C(C2=O)NC(=O)/C(=C/C=C\[C@@H]([C@H](/C(=C/[C@@H]([C@H]1O)C)/C)OC(=O)N)OC)/C
InChi: 1S/C45H58N4O12/c1-26-20-32-40(47-14-7-8-17-59-30-12-13-31-34(50)25-39(60-37(31)23-30)49-15-18-58-19-16-49)35(51)24-33(42(32)53)48-44(54)27(2)10-9-11-36(56-5)43(61-45(46)55)29(4)22-28(3)41(52)38(21-26)57-6/h9-13,22-26,28,36,38,41,43,47,52H,7-8,14-21H2,1-6H3,(H2,46,55)(H,48,54)/b11-9-,27-10+,29-22+/t26-,28+,36+,38+,41-,43+/m1/s1
InChiKey: RNEIVUJDZFEHCS-LDQBKUDJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock protein 90kDa alpha (cytosolic), class A member 1	Starlite/ChEMBL	References
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium falciparum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	heat shock protein 86, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90, related	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium berghei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	Endoplasmin precursor	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium ulcerans	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-alpha, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	putative heat shock protein 81-2	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90-like protein, related	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium parvum	Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	heat shock protein 83,heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Treponema pallidum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium hominis	heat shock protein 83	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein HSP90	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Grp94/Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	hypothetical protein	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K09487 heat shock protein 90kDa beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Theileria parva	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock 90 kDa protein homolog	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K04079 molecular chaperone HtpG, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Babesia bovis	hsp90 protein	Get druggable targets OG5_126623	All targets in OG5_126623

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0052
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.001	0	0.0001
Schistosoma mansoni	hypothetical protein	0.001	0.0003	0.0002
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0061	0.0204
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0061	0.0204
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0061	0.0204
Brugia malayi	hypothetical protein	0.0017	0.0036	0.0122
Brugia malayi	hypothetical protein	0.0017	0.0036	0.0122
Giardia lamblia	Histone acetyltransferase GCN5	0.0037	0.0137	0.0262
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0012	0.0009	0.0018
Plasmodium falciparum	endoplasmin, putative	0.0024	0.0072	0.0191
Loa Loa (eye worm)	doublecortin family protein	0.0017	0.0036	0.0122
Echinococcus multilocularis	dnaJ subfamily B	0.0303	0.1502	0.15
Mycobacterium ulcerans	hypothetical protein	0.0138	0.0656	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0072	0.032	0.0841
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0203	0.0201
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0023	0.0065	0.0208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0061	0.0059
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0031	0.0109	0.0284
Brugia malayi	Bromodomain containing protein	0.003	0.01	0.0336
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0061	0.0204
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0061	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Leishmania major	hypothetical protein, conserved	0.001	0.0002	0.0008
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.015	0.0504
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0096	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0052
Schistosoma mansoni	cellular tumor antigen P53	0.0035	0.0126	0.033
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0014	0.0045
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0012	0.0012	0.004
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0013	0.0016	0.0044
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0012	0.0012	0.0031
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0012	0.0012	0.004
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0052
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0027	0.0086	0.0289
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.007	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Plasmodium vivax	SET domain protein, putative	0.0023	0.0065	0.0165
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0203	0.0201
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0121	0.0567	0.0566
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0012	0.0009	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0036	0.0122
Schistosoma mansoni	hypothetical protein	0.0014	0.0021	0.0051
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0591	0.2976	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0138	0.0656	0.2204
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0031	0.0109	0.0358
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0591	0.2976	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0103	0.0479	0.1262
Entamoeba histolytica	acyl-coA synthetase, putative	0.0017	0.0038	0.0128
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0109	0.0366
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0027	0.0086	0.0289
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0036	0.0121
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0034	0.0124	0.0417
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0591	0.2976	0.7869
Plasmodium falciparum	heat shock protein 90	0.0039	0.015	0.0454
Onchocerca volvulus		0.0035	0.0126	0.0425
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0061	0.0156
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0038	0.012
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0036	0.0121
Leishmania major	hypothetical protein, conserved	0.0017	0.0037	0.0126
Onchocerca volvulus		0.0138	0.0656	0.2204
Echinococcus multilocularis	microtubule associated protein 2	0.0748	0.3782	0.3781
Echinococcus granulosus	transmembrane protease serine 3	0.0138	0.0656	0.173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus granulosus	Protein patched homolog 1	0.0031	0.0108	0.0281
Echinococcus multilocularis	endoplasmin	0.0031	0.0109	0.0107
Schistosoma mansoni	cpg binding protein	0.0024	0.0071	0.0183
Brugia malayi	PHD-finger family protein	0.0022	0.0059	0.02
Echinococcus multilocularis	chromobox protein 1	0.0048	0.0193	0.0191
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0155	0.0741	0.2491
Schistosoma mansoni	alpha-glucosidase	0.0104	0.0481	0.1268
Brugia malayi	heat shock protein 90	0.0039	0.015	0.0504
Brugia malayi	Hsp90 protein	0.0016	0.0031	0.0105
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0086	0.0289
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0037	0.0138	0.0464
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0124	0.0123
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0027	0.0086	0.0289
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0138	0.0656	0.173
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0012	0.0009	0.0029
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0203	0.0532
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.015	0.0504
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	transmembrane protease serine 3	0.0138	0.0656	0.0654
Brugia malayi	hypothetical protein	0.0138	0.0656	0.2204
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0591	0.2976	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0591	0.2976	0.7869
Loa Loa (eye worm)	trypsin family protein	0.0138	0.0656	0.2204
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0038	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0144	0.0483
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0124	0.0324
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0163	0.0538
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0086	0.0289
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0138	0.0656	0.0655
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.015	0.0504
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0072	0.032	0.1074
Echinococcus granulosus	fetal alzheimer antigen falz	0.0017	0.0034	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0034	0.0124	0.0409
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Brugia malayi	hypothetical protein	0.0015	0.0027	0.0092
Brugia malayi	latrophilin 2 splice variant baaae	0.0025	0.0078	0.0263
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	0.1555	0.1554
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0012	0.004
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0109	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0591	0.2976	1
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0016	0.0031	0.0105
Toxoplasma gondii	exonuclease III APE	0.0034	0.0124	0.0409
Mycobacterium ulcerans	heat shock protein 90	0.0031	0.0109	0.1629
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0037	0.0138	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0197	0.066
Schistosoma mansoni	rab6-interacting	0.0017	0.0036	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0086	0.0288
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0034	0.0124	0.0417
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0061	0.0204
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0045	0.0181	0.0475
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0061	0.0204
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0591	0.2976	1
Schistosoma mansoni	rab6-interacting	0.0017	0.0036	0.0091
Brugia malayi	cytochrome P450	0.001	0.0003	0.0009
Schistosoma mansoni	patched 1	0.0031	0.0108	0.0281
Schistosoma mansoni	hypothetical protein	0.003	0.0102	0.0266
Echinococcus multilocularis	Niemann Pick C1 protein	0.0072	0.032	0.0318
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0012	0.0009	0.0019
Brugia malayi	Trypsin-like protease protein 5	0.0138	0.0656	0.2204
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0061	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0046	0.0154
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Onchocerca volvulus		0.0138	0.0656	0.2204
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0038	0.0128
Schistosoma mansoni	microtubule-associated protein tau	0.0748	0.3782	1
Entamoeba histolytica	hypothetical protein	0.0012	0.0012	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0046	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus granulosus	heat shock protein	0.0039	0.015	0.0392
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0061	0.0059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0019	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0052
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0014	0.0019	0.0056
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0025	0.0075	0.0193
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0138	0.0656	0.1731
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0046	0.0184	0.0483
Echinococcus granulosus	glycoprotein Antigen 5	0.0138	0.0656	0.173
Echinococcus multilocularis	serine protein kinase ATM	0.0012	0.0012	0.001
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0052
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0038	0.0128
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0016	0.0031	0.0078
Leishmania major	eukaryotic initiation factor 4a, putative	0.0591	0.2976	1
Schistosoma mansoni	lipoxygenase	0.0048	0.0193	0.0507
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0013	0.0016	0.5
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.0019
Echinococcus granulosus	sterol regulatory element binding protein	0.0031	0.0108	0.0281
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0591	0.2976	0.2975
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Echinococcus multilocularis	Polycystic kidney disease protein	0.0017	0.0036	0.0034
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Schistosoma mansoni	lipoxygenase	0.0017	0.0036	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0034	0.0124	0.0217
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0038	0.0544
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0003	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Schistosoma mansoni	heat shock protein	0.0039	0.015	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Brugia malayi	CHE-14 protein	0.0031	0.0108	0.0363
Loa Loa (eye worm)	CHromoDomain protein family member	0.001	0.0002	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0511	0.1716
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0012	0.0009	0.0018
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0027	0.0086	0.0084
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0203	0.0532
Brugia malayi	Niemann-Pick C1 protein precursor	0.0072	0.032	0.1074
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.007	0.0237
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0034	0.0124	0.0417
Schistosoma mansoni	ap endonuclease	0.0034	0.0124	0.0324
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0027	0.0086	0.0289
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0147	0.0496
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0012	0.0027
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0027	0.0086	0.0289
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0109	0.0366
Brugia malayi	Bromodomain containing protein	0.0056	0.0235	0.0789
Loa Loa (eye worm)	heat shock protein 90	0.0039	0.015	0.0504
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0017	0.0038	0.3341
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0163	0.0426
Brugia malayi	Trypsin family protein	0.0138	0.0656	0.2204
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.007	0.0237
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0061	0.0204
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0203	0.0682
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0086	0.0288
Onchocerca volvulus		0.0138	0.0656	0.2204
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0591	0.2976	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Giardia lamblia	Grp94/Hsp90	0.0031	0.0109	0.0166
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0591	0.2976	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0023	0.0068	0.0227
Onchocerca volvulus		0.0138	0.0656	0.2204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.015	0.0504
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0061	0.0204
Brugia malayi	Endoplasmin precursor	0.0039	0.015	0.0504
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Brugia malayi	AMP-binding enzyme family protein	0.0017	0.0038	0.0128
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0038	0.0128
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0046	0.0185	0.0613
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0034	0.0124	0.0053
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.001	0.0003	0.0009
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.007	0.0185
Echinococcus granulosus	RUN	0.0017	0.0036	0.0091
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0017	0.0036	0.0034
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0012	0.0012	0.004
Schistosoma mansoni	loxhd1	0.0017	0.0036	0.0091
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0061	0.0204
Echinococcus granulosus	enteropeptidase	0.0138	0.0656	0.173
Schistosoma mansoni	hypothetical protein	0.0303	0.1502	0.3967
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0012	0.0012	0.0027
Echinococcus granulosus	endoplasmin	0.0031	0.0109	0.0284
Plasmodium falciparum	heat shock protein 90, putative	0.0016	0.0031	0.0053
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0021	0.0058	0.0195
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0014	0.0045
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0163	0.0538
Schistosoma mansoni	hypothetical protein	0.003	0.0102	0.0266
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0096	0.0323
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0591	0.2976	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0138	0.0656	0.0654
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0591	0.2976	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.0019
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0019	0.0065
Trypanosoma brucei	heat shock protein 84, putative	0.0016	0.0031	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0012	0.004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0027	0.0086	0.0288
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0017	0.0038	0.0544
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.001	0.0003	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Plasmodium vivax	RNA helicase-1, putative	0.0591	0.2976	1
Schistosoma mansoni	endoplasmin	0.0039	0.015	0.0392
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0003	0.0004
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0073	0.0325	0.0856
Schistosoma mansoni	hypothetical protein	0.003	0.0102	0.0266
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0591	0.2976	1
Echinococcus multilocularis	Mastin	0.0138	0.0656	0.0654
Echinococcus multilocularis	tissue type plasminogen activator	0.0017	0.0037	0.0036
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0027	0.0086	0.0281
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0121	0.0567	0.1906
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Loa Loa (eye worm)	heat shock protein 75	0.0016	0.0031	0.0105
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0061	0.0204
Schistosoma mansoni	hypothetical protein	0.001	0.0002	0.0002
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0017	0.0038	0.0544
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.007	0.0185
Onchocerca volvulus		0.007	0.0307	0.103
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Echinococcus multilocularis	RUN	0.0017	0.0036	0.0034
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0016	0.0031	0.003
Echinococcus multilocularis	tumor protein p63	0.0237	0.1162	0.1161
Plasmodium vivax	multidomain scavenger receptor, putative	0.0017	0.0036	0.007
Echinococcus granulosus	Polycystic kidney disease protein	0.0017	0.0036	0.0091
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.0036	0.0121
Leishmania major	eukaryotic initiation factor 4a, putative	0.0591	0.2976	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0034	0.0124	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0591	0.2976	0.7869
Loa Loa (eye worm)	heterochromatin protein 1	0.0048	0.0193	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0038	0.0128
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0021	0.0058	0.0149
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0038	0.0544
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.007	0.0237
Echinococcus granulosus	tissue type plasminogen activator	0.0017	0.0037	0.0094
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0061	0.0204
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0017	0.0038	0.0128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.015	0.0504
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0138	0.0656	0.0654
Onchocerca volvulus		0.0017	0.0036	0.0122
Echinococcus multilocularis	cpg binding protein	0.0024	0.0071	0.0069
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0591	0.2976	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0163	0.0497
Trichomonas vaginalis	heat shock protein, putative	0.0016	0.0031	0.0105
Loa Loa (eye worm)	bromodomain containing protein	0.0015	0.0028	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0002	0.0007
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Echinococcus granulosus	microtubule associated protein 2	0.0748	0.3782	1
Echinococcus granulosus	tumor protein p63	0.0237	0.1162	0.307
Schistosoma mansoni	hypothetical protein	0.003	0.0102	0.0266
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Onchocerca volvulus		0.0176	0.085	0.2857
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0105	0.0272
Brugia malayi	Trypsin family protein	0.0138	0.0656	0.2204
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0109	0.0366
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0027	0.0086	0.0289
Trichomonas vaginalis	ap endonuclease, putative	0.0034	0.0124	0.0417
Schistosoma mansoni	hypothetical protein	0.0025	0.0078	0.0202
Echinococcus multilocularis	protein dispatched 1	0.0035	0.0131	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Trypanosoma brucei	ISWI complex protein	0.001	0.0002	0.0008
Brugia malayi	CXXC zinc finger family protein	0.0021	0.0058	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Onchocerca volvulus		0.0017	0.0038	0.0128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0012	0.0009	0.0007
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0036	0.0121
Plasmodium vivax	heat shock protein, putative	0.0016	0.0031	0.0053
Plasmodium falciparum	cysteine repeat modular protein 1	0.0017	0.0037	0.0074
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0012	0.0012	0.0031
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Toxoplasma gondii	Hsp90 domain-containing protein	0.0016	0.0031	0.0096
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0012	0.004
Echinococcus granulosus	chromobox protein 1	0.0048	0.0193	0.0506
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0036	0.0122
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0048	0.0193	0.0507
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0086	0.0289
Schistosoma mansoni	heat shock protein	0.0016	0.0031	0.0078
Echinococcus granulosus	lysosomal alpha glucosidase	0.0121	0.0567	0.1496
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0072	0.032	0.1074
Brugia malayi	Trypsin family protein	0.0138	0.0656	0.2204
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0138	0.0656	0.173
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.015	0.0504
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Schistosoma mansoni	heat shock protein	0.0039	0.015	0.0392
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0086	0.0289
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0012	0.0012	0.0031
Leishmania major	hypothetical protein, conserved	0.0024	0.007	0.0237
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0591	0.2976	0.2975
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus multilocularis	zinc finger protein	0.0018	0.0041	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0034	0.0124	0.0324
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0012	0.0009	0.0029
Echinococcus granulosus	serine protein kinase ATM	0.0012	0.0012	0.0027
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Trypanosoma brucei	Heat shock protein 83, putative	0.0039	0.015	0.0504
Trypanosoma brucei	glucosidase, putative	0.0027	0.0086	0.0289
Trypanosoma cruzi	heat shock protein, putative	0.0016	0.0031	0.0105
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.0654
Schistosoma mansoni	zinc finger protein	0.0018	0.0041	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Toxoplasma gondii	kringle domain-containing protein	0.0017	0.0037	0.0117
Leishmania major	heat shock protein, putative	0.0016	0.0031	0.0105
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0591	0.2976	1
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0072	0.0243
Leishmania major	cytochrome p450-like protein	0.001	0.0003	0.0009
Trypanosoma cruzi	Heat shock protein 83, putative	0.0039	0.015	0.0504
Toxoplasma gondii	heat shock protein HSP90	0.0039	0.015	0.0496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0061	0.0204
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0012	0.0027
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.015	0.0504
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0133	0.0628	0.1658
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0038	0.0544
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0016	0.0031	0.0105
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0038	0.0128
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Schistosoma mansoni	hypothetical protein	0.0017	0.0036	0.0091
Loa Loa (eye worm)	endoplasmin	0.0039	0.015	0.0504
Brugia malayi	eukaryotic initiation factor 4A	0.0591	0.2976	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Onchocerca volvulus		0.0138	0.0656	0.2204
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0408
Trichomonas vaginalis	endoplasmin, putative	0.0024	0.0072	0.0243
Plasmodium falciparum	histone acetyltransferase GCN5	0.0037	0.0137	0.0411
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0034	0.0124	0.1861
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0034	0.0124	0.0367
Echinococcus multilocularis	enteropeptidase	0.0138	0.0656	0.0654
Schistosoma mansoni	bromodomain containing protein	0.0048	0.0194	0.0508
Brugia malayi	Kringle domain containing protein	0.0017	0.0037	0.0126
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0036	0.0121
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0094
Echinococcus granulosus	lipoxygenase domain containing protein	0.0017	0.0036	0.0091
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0034	0.0124	1
Trypanosoma cruzi	ISWI complex protein	0.001	0.0002	0.0008
Onchocerca volvulus		0.0021	0.0056	0.0188
Schistosoma mansoni	endoplasmin	0.0039	0.015	0.0392
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0012	0.0012	0.004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0014	0.0045
Plasmodium vivax	heat shock protein 90, putative	0.0016	0.0031	0.0053
Schistosoma mansoni	chromobox protein	0.0048	0.0193	0.0506
Schistosoma mansoni	alpha glucosidase	0.0027	0.0086	0.0223
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0108	0.0363
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0017	0.0034	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Loa Loa (eye worm)	acetyltransferase	0.0138	0.0656	0.2205
Brugia malayi	Pre-SET motif family protein	0.0023	0.0065	0.0217
Schistosoma mansoni	hypothetical protein	0.0138	0.0656	0.173
Schistosoma mansoni	alpha-glucosidase	0.0104	0.0481	0.1268
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0029	0.0096	0.0323
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0025	0.0075	0.0073
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0037	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0019	0.0065
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.001	0.0002	0.0007
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.015	0.0504
Schistosoma mansoni	cytochrome P450	0.001	0.0003	0.0002
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0031	0.0109	0.0166
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0193	0.0648
Brugia malayi	Doublecortin family protein	0.0017	0.0036	0.0122
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0034	0.0124	0.0122
Trypanosoma cruzi	heat shock protein 90, putative	0.0031	0.0109	0.0366
Echinococcus granulosus	chromobox protein 1	0.0048	0.0193	0.0506
Loa Loa (eye worm)	PHD-finger family protein	0.0014	0.0021	0.0071
Leishmania major	hypothetical protein, conserved	0.0114	0.0532	0.1788
Echinococcus granulosus	GPCR family 2	0.0012	0.0009	0.0019
Leishmania major	cytochrome p450-like protein	0.001	0.0003	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0138	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0056	0.0188
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.0012	0.001
Echinococcus multilocularis	chromobox protein 1	0.0048	0.0193	0.0191
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0203	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Schistosoma mansoni	zinc finger protein	0.001	0.0002	0.0002
Entamoeba histolytica	acetyltransferase, GNAT family	0.0037	0.0137	0.0461
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Echinococcus granulosus	Mastin	0.0138	0.0656	0.173
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0313	0.1555	0.411
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0003	0.0002
Echinococcus granulosus	heat shock protein 90	0.0039	0.015	0.0392
Echinococcus multilocularis	heat shock protein 90	0.0039	0.015	0.0148
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0017	0.0036	0.0509
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0012	0.0012	0.0031
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0027	0.0086	0.0289
Onchocerca volvulus		0.0017	0.0037	0.0126
Brugia malayi	hypothetical protein	0.0024	0.007	0.0237
Echinococcus granulosus	zinc finger protein	0.0018	0.0041	0.0103
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0203	0.0682
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0121	0.0567	0.1906
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0017	0.0037	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0061	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0078	0.0263
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0061	0.0204
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0061	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0086	0.0288
Trypanosoma cruzi	ISWI complex protein	0.001	0.0002	0.0008
Schistosoma mansoni	ap endonuclease	0.0034	0.0124	0.0324
Toxoplasma gondii	heat shock protein 90, putative	0.0039	0.015	0.0496
Plasmodium falciparum	LCCL domain-containing protein	0.0017	0.0036	0.007
Schistosoma mansoni	cpg binding protein	0.0024	0.0071	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.015	0.0306
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0023	0.0065	0.0166
Echinococcus multilocularis	expressed conserved protein	0.0068	0.0297	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0109	0.0365
Onchocerca volvulus		0.0021	0.0058	0.0195
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0012	0.0009	0.0007
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0003	0.0002
Echinococcus granulosus	cpg binding protein	0.0024	0.0071	0.0183
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Echinococcus granulosus	lipoxygenase domain containing protein	0.0017	0.0036	0.0091
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0036	0.0121
Echinococcus granulosus	dnaJ subfamily B	0.0303	0.1502	0.3967
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0061	0.0196
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0036	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0126
Brugia malayi	Cytochrome P450 family protein	0.001	0.0003	0.0009
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0038	0.0544
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0061	0.0204
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0034	0.0124	0.0417
Trypanosoma brucei	cytochrome P450, putative	0.0017	0.0036	0.0121
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.015	0.0504
Brugia malayi	exodeoxyribonuclease III family protein	0.0034	0.0124	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0024	0.007	0.0237
Trypanosoma brucei	heat shock protein, putative	0.0039	0.015	0.0504
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0017	0.0038	0.012
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0038	0.0128
Echinococcus multilocularis	heat shock protein 90	0.0031	0.0109	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0086	0.0289
Entamoeba histolytica	protein kinase rad3, putative	0.0012	0.0012	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Toxoplasma gondii	heat shock protein 75, putative	0.0016	0.0031	0.0096
Brugia malayi	Trypsin family protein	0.0138	0.0656	0.2204
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.007	0.0228
Schistosoma mansoni	polycystin 1-related	0.0017	0.0036	0.0091
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0124	0.0418
Trichomonas vaginalis	ap endonuclease, putative	0.0034	0.0124	0.0417
Brugia malayi	chromobox protein homolog 3	0.0027	0.0086	0.0288
Echinococcus granulosus	neutral alpha glucosidase AB	0.0027	0.0086	0.0223
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0086	0.0289
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0017	0.0038	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0656	0.2204
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0061	0.0156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0124	0.0324
Echinococcus granulosus	expressed conserved protein	0.0068	0.0297	0.0782
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0121	0.0567	0.0566
Brugia malayi	Pre-SET motif family protein	0.0155	0.0741	0.2491
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0012	0.0009	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0203	0.0532
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0061	0.0156
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0203	0.0532
Trichomonas vaginalis	set domain proteins, putative	0.0176	0.085	0.2857
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0138	0.0656	0.173
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0363
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0037	0.0126
Onchocerca volvulus		0.0138	0.0656	0.2204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0017	0.0038	0.0544
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.001	0.0003	0.0009
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0045	0.0181	0.018
Echinococcus multilocularis	sterol regulatory element binding protein	0.0031	0.0108	0.0106
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0031	0.0109	1
Schistosoma mansoni	hypothetical protein	0.0138	0.0656	0.173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0037	0.0138	0.0464
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0061	0.0156
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0017	0.0038	0.3341
Brugia malayi	acetyltransferase, GNAT family protein	0.0138	0.0656	0.2205
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0031	0.0109	0.0366
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0163	0.0547
Echinococcus multilocularis	GPCR, family 2	0.0012	0.0009	0.0007
Brugia malayi	Heterochromatin protein 1	0.0048	0.0193	0.0648
Loa Loa (eye worm)	TK/ROR protein kinase	0.0017	0.0037	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.028
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0012	0.0009	0.0018
Leishmania major	cytochrome p450-like protein	0.0017	0.0036	0.0121
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0193	0.0648
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0017	0.0034	0.0086
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0591	0.2976	0.7869
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0034	0.0124	0.0367
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0031	0.0108	0.0363
Echinococcus multilocularis	heat shock protein	0.0039	0.015	0.0148
Plasmodium falciparum	heat shock protein 90, putative	0.0016	0.0031	0.0053
Echinococcus multilocularis	protein patched	0.0031	0.0108	0.0106
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0138	0.0656	0.173
Brugia malayi	Latrophilin receptor protein 2	0.0012	0.0009	0.0029
Leishmania major	alpha glucosidase II subunit, putative	0.0027	0.0086	0.0289
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.001	0.0003	0.0009
Schistosoma mansoni	cercarial elastase (S01 family)	0.0138	0.0656	0.173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0027	0.0086	0.0289
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0061	0.0204
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0061	0.0204
Echinococcus granulosus	heat shock protein 90	0.0031	0.0109	0.0284
Leishmania major	heat shock protein 83-1	0.0039	0.015	0.0504
Plasmodium vivax	heat shock protein 86, putative	0.0039	0.015	0.0454
Brugia malayi	CHD4 protein	0.001	0.0002	0.0006
Schistosoma mansoni	chromobox protein	0.0048	0.0193	0.0506
Plasmodium vivax	endoplasmin, putative	0.0039	0.015	0.0454
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0017	0.0038	0.0544
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0147	0.0496
Echinococcus multilocularis	Niemann Pick C1 protein	0.0103	0.0479	0.0477
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0013	0.0016	0.0199
Loa Loa (eye worm)	cytochrome P450	0.001	0.0003	0.0009
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0591	0.2976	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0034	0.0124	0.0417
Onchocerca volvulus		0.003	0.0105	0.0351
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0163	0.0547
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0017	0.0036	0.0034
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.0019
Onchocerca volvulus		0.0017	0.0036	0.0122
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0019	0.0065
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0086	0.0289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0124	0.0324
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0061	0.0204
Toxoplasma gondii	FATC domain-containing protein	0.0012	0.0012	0.0032
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0048	0.0193	0.0192
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0023	0.0065	0.0063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0061	0.0204
Echinococcus multilocularis		0.001	0.0003	0.0001
Treponema pallidum	ATP-dependent RNA helicase	0.0591	0.2976	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0017	0.0038	0.0128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.004
Schistosoma mansoni	cpg binding protein	0.0021	0.0058	0.0149

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 10 uM	Competetive binding towards Heat shock protein HSP 90-alpha	ChEMBL.	11294389
EC50 (binding)	= 10 uM	Competetive binding towards Heat shock protein HSP 90-alpha	ChEMBL.	11294389
IC50 (binding)	= 13.9 uM	Inhibition of DNA dependent protein kinase activity without hsp90 alpha protein	ChEMBL.	11294389
IC50 (binding)	= 13.9 uM	Inhibition of DNA dependent protein kinase activity without hsp90 alpha protein	ChEMBL.	11294389
IC50 (binding)	= 200 uM	Inhibition of Phoshoinositol 3 kinase from MCF-7 breast cancer cells	ChEMBL.	11294389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL366637

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 303702