Detailed information for compound 307188

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.622 | Formula: C20H31N5O2S2
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/N=C(/NCCc1ccc(cc1)S(=O)(=O)N1CCN(C1=N)C1CCCCC1)\S
  • InChi: 1S/C20H31N5O2S2/c1-2-22-20(28)23-13-12-16-8-10-18(11-9-16)29(26,27)25-15-14-24(19(25)21)17-6-4-3-5-7-17/h8-11,17,21H,2-7,12-15H2,1H3,(H2,22,23,28)
  • InChiKey: YHPFXYQPXZBXAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0208
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1101 0.1094
Loa Loa (eye worm) hypothetical protein 0.0051 0.0347 0.0347
Echinococcus multilocularis aldo keto reductase 0.0064 0.0464 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0206 0.1011
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0049 0.0238
Brugia malayi RE40412p 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.0106
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0311 0.0304
Onchocerca volvulus 0.0031 0.0159 0.0159
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0206 0.1011
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0019 0.0048 0.0861
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0261 0.0261
Brugia malayi jmjC domain containing protein 0.0025 0.0106 0.0106
Schistosoma mansoni rab6-interacting 0.0065 0.0474 0.0467
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.042 0.0413
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0261 0.0254
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0204 0.0197
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0159 0.0152
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.042 0.1601
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0208
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0019 0.0048 0.0181
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0058 0.0696
Brugia malayi TAR-binding protein 0.0063 0.0452 0.0452
Onchocerca volvulus 0.0096 0.0757 0.0757
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0114 0.056
Schistosoma mansoni hypothetical protein 0.0082 0.063 0.0623
Loa Loa (eye worm) hypothetical protein 0.0049 0.033 0.033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0208 0.0358
Brugia malayi Bromodomain containing protein 0.0029 0.0142 0.0142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0208
Brugia malayi jmjC domain containing protein 0.0093 0.0732 0.0732
Echinococcus granulosus notch 0.003 0.0157 0.0149
Brugia malayi notch-like transmembrane receptor 0.003 0.0157 0.0157
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.009 0.0344
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0087 0.0678 0.0678
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1106 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0142 0.296
Brugia malayi Cadherin domain containing protein 0.003 0.0157 0.0157
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0206 0.1011
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0187 0.0187
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0106 0.0098
Loa Loa (eye worm) hypothetical protein 0.0096 0.0757 0.0757
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0276 0.24 0.9159
Leishmania major hypothetical protein, conserved 0.0034 0.0189 0.0722
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.1279 0.1273
Echinococcus granulosus neural cadherin 0.003 0.0157 0.0149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0106 0.0403
Schistosoma mansoni hypothetical protein 0.0254 0.22 0.2194
Trypanosoma brucei unspecified product 0.0073 0.0541 0.2065
Loa Loa (eye worm) hypothetical protein 0.0269 0.2337 0.2337
Plasmodium vivax JmjC domain containing protein 0.0025 0.0106 0.2106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1323 0.2353
Brugia malayi RNA binding protein 0.0063 0.0452 0.0452
Brugia malayi jmjC domain containing protein 0.0025 0.0106 0.0106
Schistosoma mansoni alpha-glucosidase 0.0139 0.1151 0.1145
Echinococcus granulosus dna polymerase eta 0.0078 0.0591 0.0584
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.019 0.0326
Loa Loa (eye worm) animal heme peroxidase 0.0355 0.3127 0.3127
Schistosoma mansoni tyrosine kinase 0.0059 0.042 0.0413
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0784 0.0777
Echinococcus granulosus slit 2 protein 0.003 0.0157 0.0149
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0463 0.0463
Onchocerca volvulus 0.003 0.0157 0.0157
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.1357 0.1357
Schistosoma mansoni DNA polymerase eta 0.0078 0.0591 0.0584
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0591 0.0591
Schistosoma mansoni cell polarity protein 0.003 0.0157 0.0149
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0625 0.5596 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.063 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1176 0.4487
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0049 0.0238
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0058 0.0283
Echinococcus granulosus neurogenic locus notch protein 0.003 0.0157 0.0149
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0189 0.0182
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0049 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0208
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0311 0.0311
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0225 0.0218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Onchocerca volvulus 0.0047 0.0311 0.0311
Onchocerca volvulus Neurogenic locus notch homolog 0.003 0.0157 0.0157
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.1103
Echinococcus granulosus fibropellin Ia 0.003 0.0157 0.0149
Entamoeba histolytica alcohol dehydrogenase, putative 0.0019 0.0048 0.0198
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.042 0.0413
Toxoplasma gondii aldo-keto reductase 0.0019 0.0048 0.088
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0119 0.0452
Giardia lamblia Aldose reductase 0.0064 0.0464 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.077 0.077
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0106 0.2106
Loa Loa (eye worm) RecQ helicase 0.002 0.0058 0.0058
Brugia malayi Peroxidasin 0.0355 0.3127 0.3127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0152
Trypanosoma brucei unspecified product 0.0036 0.021 0.0802
Schistosoma mansoni hypothetical protein 0.0036 0.0204 0.0197
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.042 0.0413
Brugia malayi hypothetical protein 0.0026 0.0119 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.2383
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0021 0.0021
Onchocerca volvulus 0.0355 0.3127 0.3127
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0058 0.0058
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0206 0.0858
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0106 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Brugia malayi DnaJ domain containing protein 0.0064 0.0463 0.0463
Echinococcus granulosus neurogenic locus notch protein 4 0.003 0.0157 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0049 0.0486
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0106 0.0098
Brugia malayi Protein kinase domain containing protein 0.013 0.1071 0.1071
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Echinococcus multilocularis aldo keto reductase 0.0064 0.0464 0.0457
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0276 0.24 0.9159
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0087 0.1749
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0463 0.2271
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Leishmania major DNA polymerase kappa, putative 0.0016 0.0027 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0014 0.001 0.0051
Echinococcus granulosus insulin receptor 0.013 0.1071 0.1064
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0034 0.0187 0.018
Onchocerca volvulus 0.0064 0.0464 0.0464
Schistosoma mansoni tyrosinase precursor 0.0096 0.0757 0.075
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0007 0.0028
Brugia malayi mbt repeat family protein 0.0047 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Entamoeba histolytica alcohol dehydrogenase, putative 0.0019 0.0048 0.0198
Onchocerca volvulus 0.0064 0.0464 0.0464
Loa Loa (eye worm) blistered cuticle protein 3 0.0355 0.3127 0.3127
Echinococcus multilocularis peregrin 0.0038 0.0229 0.0222
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1106 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0261 0.0254
Echinococcus multilocularis notch 0.003 0.0157 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0452 0.0445
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0157 0.0157
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1232 0.1226
Schistosoma mansoni peroxidasin 0.0355 0.3127 0.3122
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0464 0.2276
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0014 0.001 0.0053
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.042 0.0738
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0206 0.0786
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0058 0.005
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0114 0.199
Loa Loa (eye worm) TK/INSR protein kinase 0.013 0.1071 0.1071
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0208 0.429
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0049 0.0185
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0732 0.0726
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.0757 0.0757
Plasmodium falciparum aldehyde reductase, putative 0.0019 0.0048 0.0861
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0757 0.0757
Schistosoma mansoni tyrosine kinase 0.0059 0.042 0.0413
Brugia malayi hypothetical protein 0.0087 0.0678 0.0678
Echinococcus multilocularis aldo keto reductase 0.0064 0.0464 0.0457
Mycobacterium leprae Possible oxidoreductase 0.0019 0.0048 0.088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0269
Loa Loa (eye worm) oxidoreductase 0.0064 0.0464 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0027 0.0104
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0106 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0293 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.027 0.103
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0319 0.0319
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0463 0.0456
Loa Loa (eye worm) animal heme peroxidase 0.0355 0.3127 0.3127
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0474 0.0467
Mycobacterium ulcerans hypothetical protein 0.0019 0.0048 0.0072
Brugia malayi Animal haem peroxidase family protein 0.0355 0.3127 0.3127
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0591 0.2255
Brugia malayi polk-prov protein 0.0043 0.0269 0.0269
Brugia malayi Blistered cuticle protein 3 0.0355 0.3127 0.3127
Loa Loa (eye worm) hypothetical protein 0.0082 0.063 0.063
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0311 0.0304
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0633 0.0626
Entamoeba histolytica hypothetical protein 0.0036 0.0204 0.0849
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0204 0.0197
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0477 0.0477
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0319 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Mycobacterium ulcerans hypothetical protein 0.0048 0.0319 0.0558
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0474 0.0467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0732 0.0726
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0152
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Schistosoma mansoni hypothetical protein 0.0064 0.0463 0.0456
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0106 0.0098
Onchocerca volvulus 0.0018 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0065 0.0474 0.0474
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Onchocerca volvulus 0.003 0.0157 0.0157
Brugia malayi Muscle positioning protein 4 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0246 0.0239
Onchocerca volvulus 0.0064 0.0464 0.0464
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.0464 0.1771
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Echinococcus multilocularis insulin receptor 0.013 0.1071 0.1064
Giardia lamblia Aldose reductase 0.0064 0.0464 1
Trypanosoma brucei aldo-keto reductase, putative 0.0064 0.0464 0.1771
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.019 0.0326
Brugia malayi jmjC domain containing protein 0.0153 0.1279 0.1279
Brugia malayi Augmenter of liver regeneration 0.0034 0.0189 0.0189
Trypanosoma brucei unspecified product 0.0036 0.021 0.0802
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.0319 0.0319
Echinococcus granulosus GPCR family 2 0.0016 0.0021 0.0014
Schistosoma mansoni flap endonuclease-1 0.0023 0.0092 0.0084
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0528
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1176 0.4487
Echinococcus multilocularis dual specificity 0.0276 0.24 0.2395
Echinococcus multilocularis voltage gated potassium channel subunit 0.0019 0.0048 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.1103
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0027 0.0104
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0452 0.0452
Entamoeba histolytica hypothetical protein 0.0036 0.0204 0.0849
Echinococcus granulosus RUN 0.0065 0.0474 0.0467
Brugia malayi CHE-14 protein 0.0042 0.0261 0.0261
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0601 0.1063
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0049 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0119
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0058 0.005
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0114 0.0114
Onchocerca volvulus 0.0096 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.004 0.0247 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0319 0.0558
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0142 0.2896
Echinococcus granulosus arachidonate 5 lipoxygenase 0.039 0.3445 0.3441
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0239 0.2068 0.2062
Echinococcus granulosus conserved hypothetical protein 0.0014 0.001 0.0002
Schistosoma mansoni aldo-keto reductase 0.0064 0.0464 0.0457
Echinococcus granulosus jumonji domain containing protein 0.004 0.0246 0.0239
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.009 0.0148
Echinococcus granulosus delta-like protein 1 0.003 0.0157 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Onchocerca volvulus Dual oxidase homolog 0.0355 0.3127 0.3127
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.0157 0.0149
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0261 0.1279
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Brugia malayi Muscleblind-like protein 0.0148 0.1232 0.1232
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0189 0.0722
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0049 0.0049
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0474 0.0467
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0007 0.0028
Loa Loa (eye worm) oxidoreductase 0.0064 0.0464 0.0464
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0007 0.0028
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0189 0.3898
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2621 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.036 0.0353
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0371 0.0364
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Loa Loa (eye worm) animal heme peroxidase 0.0355 0.3127 0.3127
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Onchocerca volvulus Peroxidasin homolog 0.0355 0.3127 0.3127
Schistosoma mansoni polycystin 1-related 0.0065 0.0474 0.0467
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.0319 0.0319
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0106 0.0106
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.0732 0.0726
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.036 0.0353
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0259 0.0987
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.042 0.042
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0319 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0319 0.0558
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Echinococcus multilocularis protein patched 0.0042 0.0261 0.0254
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0189 0.0722
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1619 0.1613
Loa Loa (eye worm) hypothetical protein 0.0048 0.0319 0.0319
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0119 0.2383
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0786
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Brugia malayi ShTK domain containing protein 0.0096 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0106 0.0403
Onchocerca volvulus Peroxidase homolog 0.0355 0.3127 0.3127
Mycobacterium ulcerans hypothetical protein 0.0016 0.0027 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0319 0.133
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0114 0.0436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0293 0.0286
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0027 0.0428
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0114 0.0107
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0064 0.0464 0.1771
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0189 0.3984
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0276 0.24 0.9159
Schistosoma mansoni hypothetical protein 0.004 0.0247 0.024
Trypanosoma brucei prostaglandin f synthase 0.0064 0.0464 0.1771
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.033 0.033
Echinococcus granulosus aldehyde reductase 0.0046 0.0294 0.0287
Loa Loa (eye worm) hypothetical protein 0.0078 0.0591 0.0591
Brugia malayi Animal haem peroxidase family protein 0.0355 0.3127 0.3127
Onchocerca volvulus Peroxidasin homolog 0.0355 0.3127 0.3127
Echinococcus multilocularis expressed conserved protein 0.0092 0.0716 0.0709
Loa Loa (eye worm) hypothetical protein 0.0096 0.0757 0.0757
Loa Loa (eye worm) oxidoreductase 0.0064 0.0464 0.0464
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Onchocerca volvulus 0.003 0.0157 0.0157
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0189 0.0722
Echinococcus granulosus protein jagged 1 0.003 0.0157 0.0149
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0319 0.0558
Echinococcus granulosus expressed conserved protein 0.0092 0.0716 0.0709
Echinococcus multilocularis peroxidasin 0.0355 0.3127 0.3122
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.003 0.0157 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0072 0.0538 0.0538
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0319 0.1218
Brugia malayi Protein kinase domain containing protein 0.0276 0.24 0.24
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0049 0.0185
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0114 0.2341
Echinococcus granulosus bloom syndrome protein 0.002 0.0058 0.005
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Schistosoma mansoni tyrosinase precursor 0.0096 0.0757 0.075
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0452 0.0445
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.001 0.0051
Schistosoma mansoni peroxidasin 0.0355 0.3127 0.3122
Toxoplasma gondii EGF family domain-containing protein 0.003 0.0157 0.327
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.042 0.0413
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.063 0.0623
Onchocerca volvulus 0.0096 0.0757 0.0757
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0185
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.063 0.0623
Onchocerca volvulus Slit protein homolog 0.003 0.0157 0.0157
Echinococcus multilocularis 0.0017 0.0034 0.0026
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0102 0.0809 0.0809
Brugia malayi Animal haem peroxidase family protein 0.0355 0.3127 0.3127
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0239 0.2068 0.2062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0106 0.0106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0014
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Onchocerca volvulus 0.003 0.0157 0.0157
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0027 0.0104
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0259 0.5503
Brugia malayi Doublecortin family protein 0.0065 0.0474 0.0474
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0474 0.0467
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0106 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0014 0.001 0.0051
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.009 0.1812
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Schistosoma mansoni SET domain protein 0.0034 0.0185 0.0178
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0106 0.0098
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0027 0.0104
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0633 0.0626
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0027 0.0437
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0106 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.1279 0.1273
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.7243 0.7241
Echinococcus granulosus insulin growth factor 1 receptor beta 0.013 0.1071 0.1064
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0208 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0206 0.1011
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.001 0.0051
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0263 0.1005
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1153 0.1147
Echinococcus granulosus voltage gated potassium channel subunit 0.0019 0.0048 0.004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Schistosoma mansoni septate junction protein 0.003 0.0157 0.0149
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0464 0.2276
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.0106
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.0157 0.0149
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.009 0.1773
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0464 0.2276
Brugia malayi NADH-dependent xylose reductase 0.0019 0.0048 0.0048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0007 0.0028
Onchocerca volvulus 0.0014 0.0007 0.0007
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0477 0.0477
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.009 0.1812
Schistosoma mansoni alpha glucosidase 0.0036 0.0206 0.0199
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0058 0.1079
Loa Loa (eye worm) Notch2 0.003 0.0157 0.0157
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0007 0.0036
Schistosoma mansoni tyrosine kinase 0.013 0.1071 0.1064
Echinococcus granulosus protein jagged 1 0.003 0.0157 0.0149
Loa Loa (eye worm) hypothetical protein 0.0065 0.0474 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0269 0.1026
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Brugia malayi hypothetical protein 0.0065 0.0474 0.0474
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0477 0.047
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.009 0.1773
Schistosoma mansoni laminin gamma-3 chain 0.003 0.0157 0.0149
Echinococcus multilocularis GPCR, family 2 0.0016 0.0021 0.0014
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0157 0.0157
Trypanosoma brucei aldo/keto reductase, putative 0.0019 0.0048 0.0181
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0474 0.0467
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Brugia malayi hypothetical protein 0.0355 0.3127 0.3127
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0189 0.0722
Plasmodium vivax hypothetical protein, conserved 0.0014 0.001 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0082 0.063 0.0623
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0014 0.001 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0786
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0477 0.1821
Echinococcus granulosus aldo keto reductase 0.0064 0.0464 0.0457
Schistosoma mansoni pol-related 0.0064 0.0464 0.0457
Echinococcus multilocularis aldehyde reductase 0.0046 0.0294 0.0287
Echinococcus granulosus protein jagged 2 0.003 0.0157 0.0149
Plasmodium vivax SET domain protein, putative 0.0031 0.0159 0.3245
Brugia malayi Animal haem peroxidase family protein 0.0355 0.3127 0.3127
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.009 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0058 0.005
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.001 0.0002
Echinococcus multilocularis aldo keto reductase 0.0064 0.0464 0.0457
Brugia malayi hypothetical protein 0.0065 0.0474 0.0474
Entamoeba histolytica aldose reductase, putative 0.0064 0.0464 0.1933
Schistosoma mansoni loxhd1 0.0065 0.0474 0.0467
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1106 1 1
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Onchocerca volvulus 0.0014 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Echinococcus granulosus aldo keto reductase 0.0064 0.0464 0.0457
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0293 0.0293
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.0757 0.0757
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0261 0.0254
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0424 0.0424
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0007 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0027 0.0104
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0319 0.6828
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0452 0.0445
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0283
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Plasmodium vivax aldehyde reductase, putative 0.0019 0.0048 0.0861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0293 0.0286
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0206 0.0199
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0114 0.0436
Echinococcus granulosus protein jagged 2 0.003 0.0157 0.0149
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.077 0.3209
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0106 0.0098
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0319 0.6828
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0159 0.0152
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.0157 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2621 1
Echinococcus granulosus muscleblind protein 0.0148 0.1232 0.1226
Onchocerca volvulus 0.0019 0.0048 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0119 0.2383
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.2621 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Mycobacterium leprae Conserved hypothetical protein 0.0046 0.0294 0.6281
Schistosoma mansoni notch 0.003 0.0157 0.0149
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0319 0.0558
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0142 0.296
Schistosoma mansoni eyes absent homolog 0.0087 0.0678 0.0671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.019 0.0326
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.036 0.1499
Toxoplasma gondii hypothetical protein 0.0048 0.032 0.6849
Echinococcus granulosus dna polymerase kappa 0.0079 0.0601 0.0594
Schistosoma mansoni DNA helicase recq5 0.002 0.0058 0.005
Loa Loa (eye worm) tyrosinase 1 0.0096 0.0757 0.0757
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0106 0.0098
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0019 0.0048 0.004
Schistosoma mansoni serine/threonine protein kinase 0.1106 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0541 0.2065
Loa Loa (eye worm) hypothetical protein 0.0087 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Trypanosoma brucei glucosidase, putative 0.0036 0.0206 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.027 0.103
Schistosoma mansoni notch 0.003 0.0157 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.042 0.042
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0276 0.24 0.24
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0189 0.0182
Schistosoma mansoni tyrosine kinase 0.0058 0.0411 0.0404
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1176 0.4487
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.039 0.3445 0.3441
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0206 0.0199
Leishmania major DNA polymerase eta, putative 0.0078 0.0591 0.2255
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0311 0.0304
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0189 0.3984
Mycobacterium ulcerans oxidoreductase 0.0064 0.0464 0.0817
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0106 0.0403
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0474 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0049 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0027 0.0104
Loa Loa (eye worm) MBCTL1 0.0054 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Onchocerca volvulus 0.0014 0.0007 0.0007
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0106 0.0098
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0311 0.0304
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.009 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0276 0.24 0.9159
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0206 0.1011
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0058 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Echinococcus multilocularis protein jagged 1 0.003 0.0157 0.0149
Brugia malayi mbt repeat family protein 0.0047 0.0311 0.0311
Schistosoma mansoni tyrosine kinase 0.0059 0.042 0.0413
Loa Loa (eye worm) notch protein 0.003 0.0157 0.0157
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0591 0.2255
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0058 0.0058
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.0601 0.2949
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0882
Toxoplasma gondii zinc finger cdgsh type protein 0.0014 0.001 0.0053
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.022
Loa Loa (eye worm) hypothetical protein 0.0148 0.1232 0.1232
Echinococcus multilocularis neurogenic locus notch protein 4 0.003 0.0157 0.0149
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.063 0.0623
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0319 0.0558
Brugia malayi Delta serrate ligand family protein 0.003 0.0157 0.0157
Echinococcus multilocularis dna polymerase eta 0.0078 0.0591 0.0584
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0119 0.2436
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.036 0.036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0159 0.0152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0208
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0007 0.0031
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0206 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0269 0.1026
Brugia malayi jmjC domain containing protein 0.0025 0.0106 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.0276 0.24 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Echinococcus multilocularis fibropellin Ia 0.003 0.0157 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.033 0.033
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.013 0.1071 0.1064
Onchocerca volvulus 0.0355 0.3127 0.3127
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0106 0.0098
Leishmania major mitochondrial DNA polymerase beta 0.03 0.2621 1
Brugia malayi hypothetical protein 0.0017 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Loa Loa (eye worm) oxidoreductase 0.0014 0.0007 0.0007
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0019 0.0048 0.088
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0452 0.0445
Plasmodium falciparum phd finger protein, putative 0.0029 0.0142 0.2896
Echinococcus multilocularis muscleblind protein 0.0148 0.1232 0.1226
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0348 0.1327
Onchocerca volvulus 0.0014 0.001 0.001
Plasmodium falciparum aldo-keto reductase, putative 0.0019 0.0048 0.0861
Schistosoma mansoni notch 0.003 0.0157 0.0149
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.0601 0.2949
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0019 0.0048 0.088
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0477 0.1988
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0464 0.2276
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0474 0.0474
Entamoeba histolytica protein kinase, putative 0.0276 0.24 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1619 0.1613
Trypanosoma cruzi aldo-keto reductase 0.0064 0.0464 0.1771
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0208 0.0358
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.063 0.063
Brugia malayi Animal haem peroxidase family protein 0.0355 0.3127 0.3127
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0185 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0206 0.1011
Schistosoma mansoni potassium channel beta 0.0019 0.0048 0.004
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0027 0.0428
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.0732 0.0732
Schistosoma mansoni hypothetical protein 0.0065 0.0474 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.027 0.103
Schistosoma mansoni tyrosine kinase 0.013 0.1071 0.1064
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0106 0.0106
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0601 0.2294
Echinococcus granulosus neurogenic locus notch protein 0.003 0.0157 0.0149
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0027 0.0104
Brugia malayi PHD-finger family protein 0.0029 0.0142 0.0142
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0114 0.229
Entamoeba histolytica protein kinase, putative 0.0276 0.24 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Loa Loa (eye worm) hypothetical protein 0.0065 0.0474 0.0474
Echinococcus multilocularis protein jagged 1 0.003 0.0157 0.0149
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0452 0.0452
Schistosoma mansoni lipoxygenase 0.039 0.3445 0.3441
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0208 0.429
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Echinococcus granulosus hypothetical protein 0.0064 0.0464 0.0457
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0048 0.0233
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0106 0.2152
Loa Loa (eye worm) hypothetical protein 0.0064 0.0464 0.0464
Echinococcus granulosus peroxidasin 0.0355 0.3127 0.3122
Entamoeba histolytica hypothetical protein 0.0036 0.0204 0.0849
Loa Loa (eye worm) oxidoreductase 0.0064 0.0464 0.0464
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.1357 0.1351
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Echinococcus multilocularis protein dispatched 1 0.0048 0.0315 0.0308
Plasmodium falciparum flap endonuclease 1 0.0026 0.0114 0.229
Brugia malayi Pre-SET motif family protein 0.0031 0.0159 0.0159
Mycobacterium leprae conserved hypothetical protein 0.0023 0.009 0.1812
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0027 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1357 0.1351
Onchocerca volvulus 0.0355 0.3127 0.3127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Onchocerca volvulus 0.0014 0.001 0.001
Leishmania major aldo-keto reductase-like protein 0.0064 0.0464 0.1771
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0474 0.0467
Schistosoma mansoni hypothetical protein 0.004 0.0247 0.024
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0019 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Giardia lamblia High cysteine protein 0.003 0.0157 0.2963
Echinococcus granulosus flap endonuclease 1 0.0026 0.0114 0.0107
Entamoeba histolytica aldose reductase, putative 0.0064 0.0464 0.1933
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0464 0.2276
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0452 0.0452
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0319 0.1218
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0464 0.0464
Schistosoma mansoni tyrosine kinase 0.0058 0.0411 0.0404
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0106 0.2152
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0263 0.1005
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Schistosoma mansoni hypothetical protein 0.004 0.0247 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0048 0.0233
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0189 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0014
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0757 0.0757
Schistosoma mansoni rab6-interacting 0.0065 0.0474 0.0467
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0159 0.3317
Echinococcus granulosus dual specificity 0.0276 0.24 0.2395
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0027 0.0104
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1106 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0882
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0014
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0106 0.0098
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0225 0.0218
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0021 0.0021
Onchocerca volvulus 0.0064 0.0464 0.0464
Echinococcus granulosus tar DNA binding protein 0.0063 0.0452 0.0445
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0464 0.2276
Onchocerca volvulus 0.0096 0.0757 0.0757
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0269 0.2337 0.2337
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.0732 0.0726
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0114 0.0436
Onchocerca volvulus Peroxidase homolog 0.0355 0.3127 0.3127
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0206 0.1011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0263 0.1005
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.009 0.0148
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0464 0.0464
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0206 0.4351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Schistosoma mansoni aldo-keto reductase 0.0064 0.0464 0.0457
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0027 0.0104
Onchocerca volvulus 0.0064 0.0464 0.0464
Leishmania major DNA polymerase eta, putative 0.0042 0.0259 0.0987
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0007 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.036 0.036
Entamoeba histolytica hypothetical protein 0.0036 0.0204 0.0849
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.009 0.0148
Onchocerca volvulus Chorion peroxidase homolog 0.0355 0.3127 0.3127
Onchocerca volvulus Alhambra homolog 0.0029 0.0142 0.0142
Echinococcus multilocularis protein jagged 2 0.003 0.0157 0.0149
Brugia malayi jmjC domain containing protein 0.0025 0.0106 0.0106
Brugia malayi Cadherin domain containing protein 0.003 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0047 0.0311 0.0311
Leishmania major DNA damage repair protein, putative 0.0016 0.0027 0.0104
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0019 0.0048 0.0048
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0049 0.0202
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0625 0.5596 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0206 0.1011
Brugia malayi hypothetical protein 0.0036 0.0204 0.0204
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0142 0.0135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0293 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0293 0.0293
Schistosoma mansoni notch 0.003 0.0157 0.0149
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0474 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0311 0.0304
Echinococcus multilocularis RUN 0.0065 0.0474 0.0467
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.0452
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0204 0.0197
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.036 0.0353
Loa Loa (eye worm) hypothetical protein 0.0148 0.1232 0.1232
Echinococcus multilocularis dna polymerase kappa 0.0079 0.0601 0.0594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Schistosoma mansoni hypothetical protein 0.0292 0.2546 0.254
Entamoeba histolytica aldose reductase, putative 0.0064 0.0464 0.1933
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0007 0.0028
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Echinococcus granulosus aldo keto reductase 0.0064 0.0464 0.0457
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0007 0.0028
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.009 0.0344
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0058 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0293 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0293 0.0286
Brugia malayi Pre-SET motif family protein 0.0208 0.1778 0.1778
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0206 0.1011
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.077 0.0763
Entamoeba histolytica recQ family helicase, putative 0.002 0.0058 0.024
Entamoeba histolytica hypothetical protein 0.0023 0.009 0.0375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0319 0.0558
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.1357 0.1357
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0263 0.1005
Schistosoma mansoni notch 0.003 0.0157 0.0149
Schistosoma mansoni DNA helicase recq1 0.002 0.0058 0.005
Toxoplasma gondii aldose reductase, putative 0.0064 0.0464 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0452 0.0445
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.0082 0.063 0.0623
Mycobacterium tuberculosis Probable oxidoreductase 0.0064 0.0464 0.0817
Loa Loa (eye worm) hypothetical protein 0.0102 0.0809 0.0809
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0319 0.133
Leishmania major hypothetical protein, conserved 0.0025 0.0106 0.0403
Echinococcus multilocularis slit 2 protein 0.003 0.0157 0.0149
Leishmania major prostaglandin f synthase, putative 0.0064 0.0464 0.1771
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0371 0.0364
Echinococcus granulosus phd:f box containing protein 0.0025 0.0106 0.0098
Loa Loa (eye worm) hypothetical protein 0.0355 0.3127 0.3127
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0142 0.0142
Giardia lamblia DINP protein human, muc B family 0.0059 0.042 0.8983
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.0157 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0371 0.0364
Brugia malayi RE40412p 0.0014 0.001 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0319 0.0558
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0477 0.1821
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0477 0.047
Schistosoma mansoni alpha-glucosidase 0.0139 0.1151 0.1145
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0477 0.047
Onchocerca volvulus Neurogenic locus notch protein homolog 0.003 0.0157 0.0157
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0477 0.1821
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.063 0.0623
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0601 0.2294
Onchocerca volvulus 0.0065 0.0474 0.0474
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.042 0.0413
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0158 0.1323 0.2353
Onchocerca volvulus 0.0094 0.0734 0.0734
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0463 0.0456
Mycobacterium tuberculosis Conserved protein 0.0019 0.0048 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.042 0.1601
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0021 0.0021
Schistosoma mansoni slit 0.003 0.0157 0.0149
Echinococcus multilocularis bloom syndrome protein 0.002 0.0058 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0106 0.0098
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0064 0.0464 0.1771
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0157 0.0157
Schistosoma mansoni tyrosine kinase 0.0058 0.0411 0.0404
Brugia malayi GCC2 and GCC3 family protein 0.003 0.0157 0.0157
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0159 0.0152
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Echinococcus multilocularis neural cadherin 0.003 0.0157 0.0149
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0098 0.077 0.077
Echinococcus granulosus peregrin 0.0038 0.0229 0.0222
Onchocerca volvulus 0.0064 0.0464 0.0464
Onchocerca volvulus 0.0083 0.0633 0.0633
Loa Loa (eye worm) animal heme peroxidase 0.0355 0.3127 0.3127
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0206 0.0206
Schistosoma mansoni notch 0.003 0.0157 0.0149
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0371 0.0364
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0319 0.1218
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.077 0.0763
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0007 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0119 0.0452
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Loa Loa (eye worm) oxidoreductase 0.0064 0.0464 0.0464
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0014
Brugia malayi EGF-like domain containing protein 0.003 0.0157 0.0157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.036 0.0353
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0049 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0319 0.133
Schistosoma mansoni patched 1 0.0042 0.0261 0.0254
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.063 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0633 0.0633
Entamoeba histolytica hypothetical protein 0.0276 0.24 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1778 0.1778
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0114 0.0476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0464 0.0457
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Onchocerca volvulus 0.0065 0.0474 0.0474
Schistosoma mansoni lipoxygenase 0.0273 0.2372 0.2366
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0058 0.0283
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2039 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0206 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0139 0.0132
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0477 0.1821
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0464 0.2276
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0064 0.0464 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0633 0.0626
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Leishmania major hypothetical protein, conserved 0.0026 0.0119 0.0452
Leishmania major hypothetical protein, unknown function 0.0014 0.001 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0452 0.0445
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0371 0.0371
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0254 0.22 0.2194
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0311 0.0304
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0048 0.0233
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0319 0.0558
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0142 0.0135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.036 0.0631
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0041
Schistosoma mansoni hypothetical protein 0.0029 0.0142 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.24 0.2395
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1153 0.1147
Trypanosoma cruzi aldo/keto reductase, putative 0.0019 0.0048 0.0181
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0096 0.0757 0.0757
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0601 0.1063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0152
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0464 0.0457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0293 0.0286
Echinococcus multilocularis fat cadherin tumor suppressor 0.003 0.0157 0.0149
Brugia malayi Flap endonuclease-1 0.0026 0.0114 0.0114
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0185 0.0178
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0041
Schistosoma mansoni apoptosis regulator bax 0.0082 0.063 0.0623
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0464 0.0464
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0189 0.3898
Echinococcus granulosus neurogenic locus protein delta 0.003 0.0157 0.0149
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0058 0.022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.019 0.0326
Onchocerca volvulus 0.003 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1106 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0048 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0601 0.2294
Onchocerca volvulus 0.0236 0.2039 0.2039
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0371 0.0364
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0058 0.0058
Toxoplasma gondii exonuclease III APE 0.0019 0.0049 0.0902
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0019 0.0048 0.0233
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0149
Onchocerca volvulus 0.0048 0.0319 0.0319
Brugia malayi Common central domain of tyrosinase family protein 0.0096 0.0757 0.0757
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0311 0.0304
Onchocerca volvulus Putative cubilin 0.003 0.0157 0.0157
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0464 0.0464
Giardia lamblia PHD finger protein 15 0.0029 0.0142 0.2637
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1357 0.1351
Loa Loa (eye worm) RNA binding protein 0.0063 0.0452 0.0452
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1106 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0142 0.0135
Leishmania major DNA polymerase kappa, putative 0.0059 0.042 0.1601
Onchocerca volvulus 0.0102 0.0809 0.0809

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) = 0.016 mM kg-1 Hypoglycemic activity by lowering blood glucose in normal rats by 20% after oral administration. ChEMBL. 6864736
ED50 (functional) = 0.14 mM kg-1 Hypoglycemic activity by lowering blood glucose in normal rats by 50% after oral administration. ChEMBL. 6864736

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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