Detailed information for compound 335787

Basic information

Technical information
  • TDR Targets ID: 335787
  • Name: 1-[1-(4-fluorophenyl)-2-[4-[4-(2-methoxynapht halen-1-yl)butyl]piperazin-1-yl]ethyl]-4-prop an-2-ylpiperazine
  • MW: 546.762 | Formula: C34H47FN4O
  • H donors: 0 H acceptors: 0 LogP: 6.24 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1CCCCN1CCN(CC1)CC(c1ccc(cc1)F)N1CCN(CC1)C(C)C)cccc2
  • InChi: 1S/C34H47FN4O/c1-27(2)38-22-24-39(25-23-38)33(29-11-14-30(35)15-12-29)26-37-20-18-36(19-21-37)17-7-6-10-32-31-9-5-4-8-28(31)13-16-34(32)40-3/h4-5,8-9,11-16,27,33H,6-7,10,17-26H2,1-3H3
  • InChiKey: SLGLZEJKMBCODK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazin-1-yl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine
  • 1-[2-(4-fluorophenyl)-2-(4-isopropyl-1-piperazinyl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine
  • 1-[1-(4-fluorophenyl)-2-[4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazin-1-yl]ethyl]-4-propan-2-yl-piperazine
  • 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine
  • 1-[1-(4-fluorophenyl)-2-[4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl]ethyl]-4-isopropyl-piperazine
  • 1-[1-(4-fluorophenyl)-2-[4-[4-(2-methoxy-1-naphthyl)butyl]-1-piperazinyl]ethyl]-4-isopropylpiperazine
  • PDSP1_001289
  • PDSP2_001273

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0118 0.0439 0.0439
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0095 0.1508
Onchocerca volvulus 0.0118 0.0439 0.7935
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0211
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.0418 0.0418
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0103 0.1947
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0046 0.014
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus multilocularis pyruvate kinase 0.0034 0.0069 0.0069
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0103 0.0315
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0118 0.0439 0.0439
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0095 0.0814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0095 0.0095
Onchocerca volvulus 0.007 0.0229 0.3701
Brugia malayi hypothetical protein 0.0033 0.0066 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0088 0.1904
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0128 0.0484 0.0532
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0147 0.2439
Echinococcus multilocularis somatostatin receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni cathepsin D (A01 family) 0.0313 0.1294 0.1294
Echinococcus granulosus calpain A 0.0042 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus cathepsin l cysteine peptidase 0.007 0.0229 0.0229
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0155 0.0155
Echinococcus granulosus tm gpcr rhodopsin 0.062 0.2643 0.2643
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0229 0.3929
Brugia malayi Serotonin receptor 0.0118 0.0439 0.1336
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0147 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Plasmodium falciparum plasmepsin X 0.0056 0.0166 0.3275
Onchocerca volvulus 0.0118 0.0439 0.7935
Plasmodium vivax plasmepsin IV, putative 0.0128 0.0484 1
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0229 0.3929
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Brugia malayi Tachykinin-like peptides receptor 99D 0.0118 0.0439 0.1336
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0478 0.1453
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0074
Echinococcus granulosus dro:myosuppressin receptor 0.0118 0.0439 0.0439
Leishmania major pyruvate kinase 0.0034 0.0069 0.1441
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0155 0.0155
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0118 0.0439 0.1336
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0118 0.0439 0.0439
Echinococcus granulosus serotonin receptor 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Toxoplasma gondii kringle domain-containing protein 0.0034 0.0069 0.0065
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0751 0.0751
Loa Loa (eye worm) MBCTL1 0.0053 0.0155 0.0471
Plasmodium vivax unspecified product 0.0022 0.0016 0.0105
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus sex peptide receptor 0.0118 0.0439 0.0439
Brugia malayi Dopamine receptor protein 2 0.0118 0.0439 0.1336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Brugia malayi cathepsin L-like precursor 0.0049 0.0133 0.0405
Toxoplasma gondii aspartyl protease 0.0056 0.0166 0.0174
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.062 0.2643 0.2643
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0405
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0484 0.0484
Brugia malayi Cathepsin L-like precursor 0.0022 0.0016 0.005
Onchocerca volvulus 0.0047 0.0126 0.1621
Echinococcus multilocularis disks large 3 0.0023 0.0022 0.0022
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0188 0.0744 0.0744
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0118 0.0439 0.0439
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0104 0.166
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0088 0.1904
Onchocerca volvulus 0.0118 0.0439 0.7935
Loa Loa (eye worm) hypothetical protein 0.0052 0.0147 0.0446
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0042 0.0104 0.166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0155 0.0155
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0103 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0069 0.0211
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0478 0.1453
Brugia malayi 6-phosphofructokinase 0.0112 0.0413 0.1258
Schistosoma mansoni opsin-like receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis neuropeptide Y receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0117 0.0356
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0126 0.0126
Schistosoma mansoni calpain C (C02 family) 0.0042 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0058 0.0173 0.0526
Plasmodium falciparum plasmepsin I 0.0128 0.0484 1
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0413 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0107 0.2386
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Leishmania major cysteine peptidase A (CPA) 0.007 0.0229 0.5421
Schistosoma mansoni pyruvate kinase 0.0034 0.0069 0.0069
Onchocerca volvulus 0.0118 0.0439 0.7935
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0751 0.0751
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0118 0.0439 0.0439
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0103 0.1947
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0133 0.3023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0103 0.1947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0128 0.0128
Echinococcus granulosus neuropeptide FF receptor 2 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Leishmania major hypothetical protein, conserved 0.0034 0.0069 0.1443
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0095 0.0814
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi Dopamine receptor 0.0118 0.0439 0.1336
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0088 0.0268
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0128 0.0484 0.1472
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0104 0.2291
Loa Loa (eye worm) hypothetical protein 0.0142 0.0542 0.1648
Onchocerca volvulus 0.0049 0.0133 0.1756
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0118 0.0439 0.0439
Brugia malayi beta-lactamase family protein 0.004 0.0095 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0147 0.2864
Onchocerca volvulus Neuropeptide F receptor homolog 0.0118 0.0439 0.7935
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0223 0.0679
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0069 0.0065
Echinococcus multilocularis g protein coupled receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0076 0.0252 0.0767
Echinococcus granulosus neuropeptides capa receptor 0.0118 0.0439 0.0439
Schistosoma mansoni inositol monophosphatase 0.0043 0.0107 0.0107
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0046 0.014
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.0229 0.0229
Schistosoma mansoni biogenic amine receptor 0.0118 0.0439 0.0439
Onchocerca volvulus 0.0118 0.0439 0.7935
Loa Loa (eye worm) calpain family protein 1 0.0082 0.0278 0.0846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0173 0.0526
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.0886
Plasmodium falciparum plasmepsin II 0.0128 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0109 0.0331
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Onchocerca volvulus 0.0118 0.0439 0.7935
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0147 0.2864
Plasmodium falciparum plasmepsin VIII, putative 0.0056 0.0166 0.3275
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0118 0.0439 0.0439
Echinococcus granulosus cathepsin L 0.0038 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi hypothetical protein 0.0142 0.0542 0.1648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Schistosoma mansoni amine GPCR 0.0118 0.0439 0.0439
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0103 0.2287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0173 0.0526
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0093 0.0283
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi hypothetical protein 0.0056 0.0166 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0413 0.851
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.0886
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0846
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0053 0.0886
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Schistosoma mansoni biogenic amine receptor 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Plasmodium falciparum plasmepsin VII 0.0056 0.0166 0.3275
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0069 0.1226
Onchocerca volvulus 0.0118 0.0439 0.7935
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0229 0.0229
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0107 0.173
Loa Loa (eye worm) neuropeptide F receptor 0.0118 0.0439 0.1336
Echinococcus granulosus hypothetical protein 0.0118 0.0439 0.0439
Echinococcus granulosus neuropeptide receptor 0.0118 0.0439 0.0439
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0088 0.0534
Schistosoma mansoni biogenic amine (5HT) receptor 0.0118 0.0439 0.0439
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0095 0.0289
Giardia lamblia Cathepsin B precursor 0.0057 0.0169 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Schistosoma mansoni lamin 0.0029 0.0046 0.0046
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0229 0.5421
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0104 0.166
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.005
Plasmodium vivax calpain, putative 0.0042 0.0104 0.1949
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0107 0.2386
Schistosoma mansoni hypothetical protein 0.0118 0.0439 0.0439
Trypanosoma brucei glucosidase, putative 0.0042 0.0103 0.2287
Schistosoma mansoni biogenic amine receptor 0.0118 0.0439 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Loa Loa (eye worm) fibroinase 0.007 0.0229 0.0698
Echinococcus granulosus cathepsin l1 0.0049 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0133 0.2573
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0229 0.0229
Plasmodium falciparum plasmepsin IV 0.0128 0.0484 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0118 0.0439 0.0439
Schistosoma mansoni adenoreceptor 0.0118 0.0439 0.0439
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0116 0.0429 0.0429
Giardia lamblia Cathepsin B precursor 0.0057 0.0169 1
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118 0.0439 0.0439
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0118 0.0439 0.0439
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi mbt repeat family protein 0.0047 0.0126 0.0384
Onchocerca volvulus 0.007 0.0229 0.3701
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0229 0.3929
Plasmodium vivax aspartyl protease, putative 0.0056 0.0166 0.3275
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni neuropeptide F-like receptor 0.0118 0.0439 0.0439
Plasmodium vivax vivapain-1 0.0038 0.0088 0.162
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0088 0.0088
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0413 0.7248
Schistosoma mansoni cathepsin D (A01 family) 0.0313 0.1294 0.1294
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus pyruvate kinase 0.0034 0.0069 0.0069
Echinococcus granulosus cysteine protease 0.0038 0.0088 0.0088
Brugia malayi Serotonin receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) aspartyl protease 6 0.0056 0.0166 0.0506
Schistosoma mansoni amine GPCR 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0088 0.1904
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0104 0.0104
Echinococcus granulosus alpha 1A adrenergic receptor 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0095 0.1771
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.2291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Brugia malayi Protein kinase domain containing protein 0.0034 0.0069 0.0211
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0118 0.0439 0.0439
Plasmodium falciparum cysteine proteinase falcipain 2b 0.007 0.0229 0.4614
Loa Loa (eye worm) hypothetical protein 0.0047 0.0126 0.0384
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0038 0.0088 0.138
Schistosoma mansoni neuropeptide receptor 0.0118 0.0439 0.0439
Schistosoma mansoni cell polarity protein 0.0023 0.0022 0.0022
Plasmodium falciparum plasmepsin VI 0.0128 0.0484 1
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0107 0.0107
Echinococcus multilocularis cathepsin L 0.0038 0.0088 0.0088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0747 0.0747
Onchocerca volvulus Cathepsin L homolog 0.007 0.0229 0.3701
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Echinococcus granulosus disks large 3 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0098 0.0351 0.1069
Echinococcus multilocularis G protein coupled receptor 139 0.0118 0.0439 0.0439
Echinococcus granulosus G protein coupled receptor 139 0.0118 0.0439 0.0439
Trichomonas vaginalis esterase, putative 0.004 0.0095 0.1771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0118 0.0439 0.7935
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.007 0.0229 0.0698
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.0252 0.5096
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0104 0.2291
Brugia malayi 6-phosphofructokinase 0.0112 0.0413 0.1258
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0147 0.2439
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0069 0.0564
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0252 0.0252
Plasmodium vivax vivapain-3 0.0038 0.0088 0.162
Echinococcus granulosus tachykinin peptides receptor 99D 0.1054 0.4549 0.4549
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0103 0.1947
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.0229 0.4614
Plasmodium vivax unspecified product 0.0038 0.0088 0.162
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0147 0.3365
Echinococcus multilocularis neuropeptide s receptor 0.0118 0.0439 0.0439
Toxoplasma gondii melibiase subfamily protein 0.0113 0.0418 0.0458
Leishmania major hypothetical protein, conserved 0.0052 0.0147 0.3365
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0016 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0103 0.1658
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi hypothetical protein 0.0052 0.0147 0.0446
Loa Loa (eye worm) calpain 5 0.0029 0.0048 0.0147
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0103 0.0103
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0118 0.0439 0.1336
Onchocerca volvulus Huntingtin homolog 0.0142 0.0542 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0418 0.0418
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0069 0.0211
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Brugia malayi neuropeptide F receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.007 0.0229 0.0698
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0118 0.0439 0.0439
Echinococcus multilocularis cysteine protease 0.007 0.0229 0.0229
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0095 0.2081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0057 0.0169 0.3925
Onchocerca volvulus 0.0118 0.0439 0.7935
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0126 0.0126
Echinococcus multilocularis fmrfamide receptor 0.0118 0.0439 0.0439
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0046 0.014
Echinococcus multilocularis lamin 0.0029 0.0046 0.0046
Echinococcus granulosus biogenic amine 5HT receptor 0.0118 0.0439 0.0439
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0048 0.0918
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0034 0.0069 0.1228
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Brugia malayi Guanylate kinase family protein 0.0026 0.0033 0.01
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0011 0.0011
Loa Loa (eye worm) melatonin receptor type 1A 0.0118 0.0439 0.1336
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0095 0.0814
Entamoeba histolytica cysteine protease, putative 0.007 0.0229 0.5421
Echinococcus granulosus g protein coupled receptor 0.0118 0.0439 0.0439
Schistosoma mansoni alpha-glucosidase 0.0162 0.0631 0.0631
Echinococcus granulosus cathepsin L cysteine protease 0.0038 0.0088 0.0088
Schistosoma mansoni biogenic amine (5HT) receptor 0.0118 0.0439 0.0439
Giardia lamblia Cathepsin B precursor 0.0057 0.0169 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0118 0.0439 0.0439
Echinococcus granulosus calpain 7 C02 family 0.0042 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Echinococcus granulosus cathepsin b 0.0147 0.0566 0.0566
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0088 0.138
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0011 0.0011
Echinococcus multilocularis cathepsin b 0.0147 0.0566 0.0566
Echinococcus granulosus tissue type plasminogen activator 0.0034 0.0069 0.0069
Loa Loa (eye worm) beta-lactamase 0.004 0.0095 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0229 0.3929
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni lamin 0.0029 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Schistosoma mansoni hypothetical protein 0.0042 0.0103 0.0103
Loa Loa (eye worm) cysteine protease 0.007 0.0229 0.0698
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0069 0.1044
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0128 0.0484 0.0484
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0016 0.0089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0118 0.0439 0.0439
Plasmodium vivax aspartyl proteinase, putative 0.0128 0.0484 1
Schistosoma mansoni hypothetical protein 0.0118 0.0439 0.0439
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0118 0.0439 0.0439
Schistosoma mansoni neuropeptide receptor 0.0118 0.0439 0.0439
Entamoeba histolytica hypothetical protein 0.0042 0.0103 0.2265
Echinococcus multilocularis musashi 0.0029 0.0046 0.0046
Entamoeba histolytica cysteine proteinase 1, putative 0.0038 0.0088 0.1904
Brugia malayi hypothetical protein 0.0042 0.0103 0.0312
Onchocerca volvulus 0.004 0.0095 0.0992
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0173 0.0526
Echinococcus multilocularis calpain 7 (C02 family) 0.0042 0.0104 0.0104
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0056 0.0166 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Brugia malayi hypothetical protein 0.0056 0.0166 0.0506
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0413 0.1258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Echinococcus multilocularis serotonin receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1054 0.4549 0.4549
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0405
Echinococcus multilocularis pyruvate kinase 0.0027 0.0038 0.0038
Onchocerca volvulus 0.004 0.0095 0.0992
Echinococcus granulosus intermediate filament protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0116 0.0429 0.0429
Echinococcus granulosus 7tm_1 domain containing protein 0.0118 0.0439 0.0439
Brugia malayi ORL1-like opioid receptor 0.0118 0.0439 0.1336
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0418 0.0418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0747 0.0747
Schistosoma mansoni amine GPCR 0.0118 0.0439 0.0439
Loa Loa (eye worm) neuropeptide F receptor 0.0118 0.0439 0.1336
Brugia malayi Dopamine receptor protein 1 0.0118 0.0439 0.1336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.0566 0.0566
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0103 0.2287
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0118 0.0439 0.0439
Echinococcus multilocularis dro:myosuppressin receptor 0.0118 0.0439 0.0439
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.1039 1
Loa Loa (eye worm) guanylate kinase 0.0019 0.0005 0.0014
Leishmania major pyruvate kinase 0.0034 0.0069 0.1441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0095 0.1771
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni hypothetical protein 0.0188 0.0744 0.0744
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0069 0.1226
Brugia malayi G-protein coupled receptor 0.0118 0.0439 0.1336
Schistosoma mansoni hypothetical protein 0.0118 0.0439 0.0439
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0069 0.0473
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.166
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0069 0.1046
Loa Loa (eye worm) cathepsin B 0.0057 0.0169 0.0515
Echinococcus multilocularis calpain A 0.0116 0.0429 0.0429
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0126 0.1621
Echinococcus multilocularis cathepsin b 0.0147 0.0566 0.0566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0405
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0229 0.3929
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0069 0.1044
Echinococcus granulosus neuropeptide Y receptor 0.0118 0.0439 0.0439
Brugia malayi MH2 domain containing protein 0.0127 0.0478 0.1453
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0103 0.1947
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0116 0.0429 0.0429
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0056 0.0166 0.0174
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0133
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0418 0.0418
Schistosoma mansoni amine GPCR 0.0118 0.0439 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0095 0.1771
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0024 0.0316
Onchocerca volvulus 0.007 0.0229 0.3701
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0118 0.0439 0.0439
Onchocerca volvulus 0.0118 0.0439 0.7935
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0155 0.0471
Echinococcus multilocularis cysteine protease 0.007 0.0229 0.0229
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Plasmodium vivax vivapain-2 0.007 0.0229 0.4614
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0069 0.1441
Brugia malayi G-protein coupled receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus multilocularis g protein coupled receptor 0.0118 0.0439 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0128 0.0128
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.0747 0.0747
Loa Loa (eye worm) AStacin protease 0.0028 0.0043 0.0131
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0118 0.0439 0.0439
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0147 0.0152
Brugia malayi cathepsin B-like cysteine proteinase 0.0147 0.0566 0.1722
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0088 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0506
Chlamydia trachomatis pyruvate kinase 0.0034 0.0069 1
Leishmania major kinesin, putative 0.0029 0.0048 0.0918
Echinococcus granulosus Tolloid protein 1 0.0045 0.0117 0.0117
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0413 0.0413
Onchocerca volvulus 0.0118 0.0439 0.7935
Echinococcus multilocularis orexin receptor type 2 0.0118 0.0439 0.0439
Echinococcus multilocularis sex peptide receptor 0.0118 0.0439 0.0439
Schistosoma mansoni neuropeptide receptor 0.0118 0.0439 0.0439
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0095 0.1771
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0095 0.0814
Plasmodium vivax plasmepsin V, putative 0.0056 0.0166 0.3275
Echinococcus granulosus neuropeptides capa receptor 0.0118 0.0439 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0128 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0413 0.851
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus allatostatin A receptor 0.0118 0.0439 0.0439
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0103 0.1658
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0049 0.0133 0.2191
Plasmodium falciparum cysteine repeat modular protein 1 0.0034 0.0069 0.1228
Plasmodium falciparum cysteine proteinase falcipain 2a 0.007 0.0229 0.4614
Brugia malayi sulfakinin receptor protein 0.0767 0.3286 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.2291
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0103 0.0103
Entamoeba histolytica cysteine proteinase 2 0.0038 0.0088 0.1904
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0413 1
Schistosoma mansoni hypothetical protein 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0118 0.0439 0.1336
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0118 0.0439 0.0439
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0118 0.0439 0.1336
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.166
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0413 0.1258
Toxoplasma gondii ABC1 family protein 0.004 0.0095 0.0094
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0053 0.0047
Schistosoma mansoni myosin xvIII 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Echinococcus granulosus peptide allatostatin:somatostatin 0.0118 0.0439 0.0439
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0413 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0103 0.1947
Schistosoma mansoni intermediate filament proteins 0.0029 0.0046 0.0046
Brugia malayi larval opioid receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) G-protein coupled receptor 0.0118 0.0439 0.1336
Echinococcus multilocularis calpain 5 0.0042 0.0104 0.0104
Brugia malayi hypothetical protein 0.0767 0.3286 1
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni pyruvate kinase 0.0034 0.0069 0.0069
Echinococcus granulosus g-protein coupled receptor 0.0118 0.0439 0.0439
Onchocerca volvulus 0.007 0.0229 0.3701
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0126 0.0126
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0413 0.851
Echinococcus multilocularis calpain 0.0042 0.0104 0.0104
Echinococcus granulosus cathepsin L cysteine proteinase 0.007 0.0229 0.0229
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0126 0.0384
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Loa Loa (eye worm) hypothetical protein 0.0147 0.0566 0.1722
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0103 0.1947
Echinococcus granulosus neuropeptide Y receptor 0.0118 0.0439 0.0439
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0103 0.0103
Brugia malayi calpain 7 0.0042 0.0104 0.0315
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Echinococcus multilocularis fmrfamide receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0767 0.3286 1
Echinococcus multilocularis calpain family protein 1, d 0.0082 0.0278 0.0278
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0104 0.166
Echinococcus multilocularis hypothetical protein 0.0042 0.0104 0.0104
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.0886
Schistosoma mansoni neuropeptide f receptor 76f 0.0118 0.0439 0.0439
Brugia malayi Eukaryotic aspartyl protease family protein 0.0056 0.0166 0.0506
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0118 0.0439 0.1336
Brugia malayi putative neuropeptide receptor 0.0118 0.0439 0.1336
Toxoplasma gondii aspartyl protease ASP1 0.0128 0.0484 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.0229 0.4614
Onchocerca volvulus 0.007 0.0229 0.3701
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0088 0.0743
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0095 0.2081
Loa Loa (eye worm) hypothetical protein 0.0018 0 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0088 0.0268
Echinococcus multilocularis g-protein coupled receptor 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0229 0.5421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Mycobacterium ulcerans hypothetical protein 0.004 0.0095 0.2081
Loa Loa (eye worm) hypothetical protein 0.0142 0.0542 0.1648
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0104 0.166
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0088 0.1904
Loa Loa (eye worm) TYRA-2 protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0118 0.0439 0.1336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0095 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Echinococcus multilocularis neuropeptide receptor A26 0.0118 0.0439 0.0439
Schistosoma mansoni histamine h1 receptor 0.0118 0.0439 0.0439
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.0566 0.0566
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi calpain family protein 1 0.0111 0.0407 0.1237
Brugia malayi GnHR receptor homolog 0.0118 0.0439 0.1336
Onchocerca volvulus 0.0109 0.0398 0.7105
Onchocerca volvulus 0.0118 0.0439 0.7935
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0126 0.0126
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0118 0.0439 0.1336
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0069 0.1441
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0128 0.0388
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Echinococcus granulosus pyruvate kinase 0.0034 0.0069 0.0069
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0053 0.0047
Trypanosoma brucei cysteine peptidase C (CPC) 0.0057 0.0169 0.3925
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0042 0.0104 0.2291
Echinococcus granulosus lamin 0.0029 0.0046 0.0046
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Echinococcus granulosus cathepsin b 0.0147 0.0566 0.0566
Schistosoma mansoni hypothetical protein 0.029 0.1192 0.1192
Onchocerca volvulus 0.0056 0.0166 0.2426
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus fmrfamide receptor 0.0118 0.0439 0.0439
Mycobacterium ulcerans lipase LipD 0.004 0.0095 0.2081
Onchocerca volvulus 0.007 0.0229 0.3701
Echinococcus multilocularis neuropeptides capa receptor 0.0118 0.0439 0.0439
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0095 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0107 0.0108
Onchocerca volvulus 0.0118 0.0439 0.7935
Leishmania major hypothetical protein, conserved 0.004 0.0095 0.2081
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi neuropeptide F receptor 0.0118 0.0439 0.1336
Echinococcus granulosus somatostatin receptor 0.0118 0.0439 0.0439
Schistosoma mansoni growth hormone secretagogue receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0088 0.1904
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0016 0.005
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0413 0.0413
Echinococcus granulosus neuropeptide receptor A26 0.0118 0.0439 0.0439
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0118 0.0439 0.0439
Plasmodium vivax aspartyl proteinase, putative 0.0056 0.0166 0.3275
Loa Loa (eye worm) ctsf protein 0.007 0.0229 0.0698
Mycobacterium leprae Probable lipase LipE 0.004 0.0095 0.0747
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0011
Plasmodium vivax hypothetical protein, conserved 0.004 0.0095 0.1771
Mycobacterium ulcerans beta-lactamase 0.004 0.0095 0.2081
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Schistosoma mansoni opsin-like receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0128 0.0128
Loa Loa (eye worm) calpain 0.0042 0.0104 0.0315
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0118 0.0439 0.0439
Brugia malayi Melatonin receptor type 1A 0.0118 0.0439 0.1336
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.2291
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0413 0.0413
Echinococcus multilocularis microtubule associated protein 2 0.2296 1 1
Plasmodium falciparum plasmepsin V 0.0056 0.0166 0.3275
Schistosoma mansoni microtubule-associated protein tau 0.2296 1 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0042 0.0104 0.0104
Onchocerca volvulus 0.0118 0.0439 0.7935
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis lamin dm0 0.0029 0.0046 0.0046
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0053 0.2652
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0413 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Trypanosoma cruzi kinesin, putative 0.0029 0.0048 0.0665
Schistosoma mansoni alpha-glucosidase 0.0162 0.0631 0.0631
Plasmodium falciparum plasmepsin III 0.0056 0.0166 0.3275
Echinococcus granulosus tm gpcr rhodopsin 0.0118 0.0439 0.0439
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0095 0.0814
Schistosoma mansoni alpha glucosidase 0.0042 0.0103 0.0103
Mycobacterium leprae conserved hypothetical protein 0.004 0.0095 0.0747
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0103 0.1947
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.0747 0.2272
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0107 0.2031
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Echinococcus granulosus lamin dm0 0.0029 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0169 0.3341
Echinococcus granulosus calpain A 0.0116 0.0429 0.0429
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Onchocerca volvulus 0.0069 0.0223 0.3573
Brugia malayi G protein-coupled receptor F59B2.13 0.0118 0.0439 0.1336
Echinococcus granulosus 7TM GPCR rhodopsin 0.0118 0.0439 0.0439
Echinococcus granulosus g protein coupled receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0039 0.0093 0.0283
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0133 0.0133
Schistosoma mansoni cathepsin s 0.0022 0.0016 0.0016
Echinococcus granulosus neuropeptide receptor 0.0118 0.0439 0.0439
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0418 0.0418
Schistosoma mansoni neuropeptide receptor 0.0118 0.0439 0.0439
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0118 0.0439 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Schistosoma mansoni opsin-like receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.0229 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0147 0.2864
Plasmodium falciparum cysteine proteinase falcipain 3 0.007 0.0229 0.4614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0229 0.5421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0088 0.162
Plasmodium vivax aspartyl protease, putative 0.0056 0.0166 0.3275
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0133 0.2573
Echinococcus granulosus neuropeptide s receptor 0.0118 0.0439 0.0439
Plasmodium falciparum cysteine proteinase falcipain 1 0.0038 0.0088 0.162
Onchocerca volvulus Cathepsin F homolog 0.007 0.0229 0.3701
Loa Loa (eye worm) G-protein coupled receptor 0.0118 0.0439 0.1336
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0107 0.2031
Trypanosoma brucei kinesin, putative 0.0029 0.0048 0.0918
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0022 0.0017 0.005
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0413 1
Brugia malayi Melibiase family protein 0.0076 0.0252 0.0767
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0252 0.0252
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0126 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0107 0.2031
Onchocerca volvulus 0.007 0.0229 0.3701
Schistosoma mansoni amine GPCR 0.0118 0.0439 0.0439
Echinococcus granulosus calpain 0.0042 0.0104 0.0104
Onchocerca volvulus Huntingtin homolog 0.0142 0.0542 1
Schistosoma mansoni inositol monophosphatase 0.0043 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0024 0.0074
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0118 0.0439 0.0439
Brugia malayi G protein-coupled receptor 0.0118 0.0439 0.1336
Echinococcus multilocularis g protein coupled receptor 0.0118 0.0439 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Schistosoma mansoni memapsin-2 (A01 family) 0.0458 0.1932 0.1932
Echinococcus granulosus cathepsin l1 0.007 0.0229 0.0229
Echinococcus multilocularis neuropeptide receptor 0.0118 0.0439 0.0439
Echinococcus granulosus geminin 0.0188 0.0744 0.0744
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.0418 0.0418
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0413 1
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0069 0.1441
Brugia malayi intermediate filament protein 0.0029 0.0046 0.014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.0229 0.0229
Brugia malayi phosphofructokinase 0.0112 0.0413 0.1258
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0103 0.0104
Brugia malayi Cathepsin L-like precursor 0.0049 0.0133 0.0405
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0128 0.0388
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0413 0.0413
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0413 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0103 0.2287
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.0886
Echinococcus granulosus orexin receptor type 2 0.0118 0.0439 0.0439
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0229 0.0698
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0069 0.0211
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0147 0.0566 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0103 0.0103
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0053 0.0155 0.0471
Brugia malayi aspartic protease BmAsp-1, identical 0.0056 0.0166 0.0506
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0088 0.138
Mycobacterium tuberculosis Conserved protein 0.004 0.0095 0.0814
Onchocerca volvulus 0.0118 0.0439 0.7935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Echinococcus multilocularis neuropeptide receptor 0.0118 0.0439 0.0439
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Brugia malayi beta-lactamase family protein 0.004 0.0095 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Onchocerca volvulus Cathepsin L homolog 0.007 0.0229 0.3701
Echinococcus multilocularis neuropeptides capa receptor 0.0118 0.0439 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0088 0.162
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0095 0.1508
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0069 0.0211
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Brugia malayi Kringle domain containing protein 0.0034 0.0069 0.0211
Entamoeba histolytica cysteine protease, putative 0.0038 0.0088 0.1904
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0126 0.0126
Echinococcus multilocularis pyruvate kinase 0.0034 0.0069 0.0069
Mycobacterium tuberculosis Conserved protein 0.004 0.0095 0.0814
Entamoeba histolytica hypothetical protein 0.0042 0.0103 0.2265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0011 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0016 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0057 0.0169 0.2845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Onchocerca volvulus 0.0118 0.0439 0.7935
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0128 0.0484 0.1472
Onchocerca volvulus 0.0118 0.0439 0.7935
Echinococcus granulosus calpain 5 0.0042 0.0104 0.0104
Loa Loa (eye worm) TK/ROR protein kinase 0.0034 0.0069 0.0211
Echinococcus multilocularis neuropeptide Y receptor 0.0118 0.0439 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118 0.0439 0.0439
Plasmodium vivax vivapain-2 0.007 0.0229 0.4614
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0211
Entamoeba histolytica hypothetical protein 0.0042 0.0103 0.2265
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0413 0.1258
Echinococcus multilocularis serotonin receptor 0.0118 0.0439 0.0439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0169 0.0169
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0069 0.0473
Toxoplasma gondii aspartyl protease ASP3 0.0056 0.0166 0.0174
Onchocerca volvulus 0.004 0.0095 0.0992
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0011 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0506
Brugia malayi aspartic protease BmAsp-2, identical 0.0056 0.0166 0.0506
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0118 0.0439 0.0439
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0103 0.0315
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0229 0.0698
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0107 1
Toxoplasma gondii cathepsin CPL 0.007 0.0229 0.0245
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0107 0.0107
Brugia malayi putative neuropeptide receptor NPR1 0.0118 0.0439 0.1336
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0107 0.2386
Brugia malayi calpain family protein 1 0.0111 0.0407 0.1237
Echinococcus multilocularis G-protein coupled receptor, putative 0.0118 0.0439 0.0439
Loa Loa (eye worm) inositol-1 0.0043 0.0107 0.0327
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0069 0.0473
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0413 0.851
Brugia malayi Cathepsin L-like precursor 0.0049 0.0133 0.0405
Toxoplasma gondii cathepsin B 0.0057 0.0169 0.0178
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0107 0.2386
Echinococcus multilocularis neuropeptide FF receptor 2 0.0118 0.0439 0.0439
Plasmodium falciparum pyruvate kinase 0.0034 0.0069 0.1226
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0413 1
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0093
Brugia malayi beta-lactamase 0.004 0.0095 0.0289
Loa Loa (eye worm) calpain family protein 1 0.0111 0.0407 0.1237
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0126 0.0126
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0022 0.0022
Trypanosoma cruzi cysteine protease, putative 0.0038 0.0088 0.138
Mycobacterium tuberculosis Conserved protein 0.004 0.0095 0.0814
Brugia malayi RE15519p 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0128 0.0128
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.0747 0.2272
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0116 0.0429 0.0429
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0104 0.2291
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0095 0.0289
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0069 0.1226
Trypanosoma brucei antigen, putative 0.0042 0.0104 0.2291
Brugia malayi Inositol-1 0.0043 0.0107 0.0327
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.2291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0128 0.0128
Onchocerca volvulus 0.0034 0.0069 0.0475
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0886
Brugia malayi calpain 5 0.0029 0.0048 0.0147
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0088 0.1904
Leishmania major cathepsin L-like protease 0.007 0.0229 0.5421
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.2043 0.889 1
Entamoeba histolytica protein kinase, putative 0.0029 0.0048 0.0918
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Trypanosoma cruzi kinesin, putative 0.0029 0.0048 0.0665
Entamoeba histolytica hypothetical protein 0.0042 0.0103 0.2265
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0053 0.1041
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0053 0.1041
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0229 0.4614
Brugia malayi hypothetical protein 0.0118 0.0439 0.1336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0107 0.173
Schistosoma mansoni neuropeptide F-like receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis geminin 0.0188 0.0744 0.0744
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0128 0.0484 0.0484
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0095 0.0095
Giardia lamblia Pyruvate kinase 0.0034 0.0069 0.3671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0229 0.4614
Loa Loa (eye worm) hypothetical protein 0.0111 0.0407 0.1237
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0103 0.1947
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0053 0.0047
Brugia malayi mbt repeat family protein 0.0047 0.0126 0.0384
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0104 0.166
Brugia malayi AKH receptor 0.0118 0.0439 0.1336
Loa Loa (eye worm) hypothetical protein 0.0118 0.0439 0.1336
Echinococcus granulosus g protein coupled receptor 0.0118 0.0439 0.0439
Brugia malayi follicle stimulating hormone receptor 0.0118 0.0439 0.1336
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0104 0.166
Brugia malayi Cathepsin L-like precursor 0.007 0.0229 0.0698
Brugia malayi Pepsin A precursor 0.0056 0.0166 0.0506
Onchocerca volvulus 0.0118 0.0439 0.7935
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0095 0.2081
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0118 0.0439 0.0439
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0095 0.0814
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0166 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0111 0.0407 0.0407
Echinococcus multilocularis tissue type plasminogen activator 0.0034 0.0069 0.0069
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0104 0.2291
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0088 0.0088
Schistosoma mansoni calpain (C02 family) 0.0042 0.0104 0.0104
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0069 0.0211
Onchocerca volvulus 0.0056 0.0166 0.2426
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0118 0.0439 0.0439
Schistosoma mansoni hypothetical protein 0.0034 0.0069 0.0069
Plasmodium falciparum plasmepsin IX 0.0056 0.0166 0.3275
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0128 0.0484 1
Plasmodium vivax aspartyl protease, putative 0.0056 0.0166 0.3275
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0133 0.0405
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0413 0.3913
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118 0.0439 0.0439
Echinococcus multilocularis allatostatin A receptor 0.0118 0.0439 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0095 0.1771
Echinococcus granulosus rhodopsin orphan GPCR 0.0118 0.0439 0.0439
Echinococcus granulosus tm gpcr rhodopsin 0.0118 0.0439 0.0439

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8.13 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
IC50 (binding) = 8.13 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
IC50 (binding) = 12.7 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
IC50 (binding) = 12.7 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
IC50 (binding) = 22 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
IC50 (binding) = 22 nM Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells ChEMBL. 17234422
Ki (binding) = 7.9 nM Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand ChEMBL. 15863313
Ki (binding) = 7.9 nM Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand ChEMBL. 15863313

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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