Detailed information for compound 34893

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.835 | Formula: C19H12ClN3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(ccc1Sc1ccc2c(c1)cccc2)n1ncc(=O)[nH]c1=O
  • InChi: 1S/C19H12ClN3O2S/c20-16-10-14(23-19(25)22-18(24)11-21-23)6-8-17(16)26-15-7-5-12-3-1-2-4-13(12)9-15/h1-11H,(H,22,24,25)
  • InChiKey: ZQJQNWYVIORWMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0201 0.0476
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0167
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0011 0.0002 0.0003
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Chlamydia trachomatis DNA polymerase I 0.0065 0.0106 1
Treponema pallidum DNA ligase (lig) 0.0021 0.0022 0.1931
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0001 0.001
Echinococcus granulosus microtubule associated protein 2 0.2184 0.4201 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0126 0.0885
Echinococcus granulosus FTZ F1 alpha 0.001 0.0001 0.0003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0126 0.1071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Schistosoma mansoni microtubule-associated protein tau 0.2184 0.4201 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0312 0.0583 0.118
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0024 0.019
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0019 0.0149
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0065 0.0106 0.8396
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0001 0.0002
Giardia lamblia DINP protein human, muc B family 0.002 0.002 0.0066
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0024 0.0381
Leishmania major cytochrome p450-like protein 0.002 0.0019 0.0064
Brugia malayi SWIRM domain containing protein 0.0043 0.0065 0.0089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0012
Onchocerca volvulus 0.0019 0.0018 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.1096
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0167
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.009 0.0814
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0024 0.0081
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0019 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0066
Onchocerca volvulus 0.0019 0.0018 0.0016
Echinococcus multilocularis 0.0043 0.0065 0.013
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0038 0.0265
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.0353 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Schistosoma mansoni DNA ligase IV 0.0021 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0167
Leishmania major UDP-galactopyranose mutase 0.0043 0.0065 0.0231
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0011 0.0002 0.0003
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0312 0.0583 0.4087
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0024 0.0205
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0065 0.013
Entamoeba histolytica hypothetical protein 0.0114 0.0201 0.3431
Schistosoma mansoni tar DNA-binding protein 0.013 0.0233 0.0552
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0022 0.0074
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0022 0.003
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0452 0.0854 0.2033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0022 0.0074
Brugia malayi Patched related family protein 4 0.0019 0.0018 0.0024
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0022 0.0074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0233 0.1636
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0001 0.0002
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0019 0.0017 0.0271
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0022 0.0044
Schistosoma mansoni topbp1 0.0021 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0046 0.007 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0022
Echinococcus multilocularis muscleblind protein 1 0.0473 0.0895 0.1811
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.0748 0.1427 0.3397
Brugia malayi Cytochrome P450 family protein 0.002 0.0019 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0001 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0019 0.0161
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0019 0.0161
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0022 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0081 0.0111
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0081
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0019 0.0149
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0024 0.0081
Onchocerca volvulus 0.0019 0.0018 0.0016
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0065 0.0231
Brugia malayi hypothetical protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0011 0.0002 0.0012
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0316 0.0593 0.1408
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0019 0.0064
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0024 0.0081
Onchocerca volvulus Protein patched homolog 0.0019 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0011 0.0002 0.0002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0024 0.0048
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Onchocerca volvulus 0.0032 0.0043 0.0041
Brugia malayi nuclear hormone receptor 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0019 0.0161
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0003
Brugia malayi protein C24B5.3 0.0019 0.0018 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0002
Toxoplasma gondii helicase, putative 0.0019 0.0017 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0019 0.0161
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0126 0.2141
Brugia malayi protein C24B5.3 0.0019 0.0018 0.0024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.002 0.0066
Toxoplasma gondii hypothetical protein 0.0019 0.0018 0.0059
Echinococcus granulosus dna polymerase eta 0.002 0.002 0.0046
Trypanosoma brucei telomerase reverse transcriptase 0.1416 0.2718 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0024 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Onchocerca volvulus 0.0022 0.0024 0.0022
Echinococcus granulosus Niemann Pick C1 protein 0.0312 0.0583 0.1388
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0065 0.0583
Schistosoma mansoni importin beta-1 0.003 0.0039 0.0089
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0011 0.0002 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0084 0.076
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0019 0.0017 0.0058
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0019 0.0149
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0038 0.0133
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Treponema pallidum DNA polymerase I (polA) 0.0065 0.0106 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0065 0.0153
Schistosoma mansoni DNA polymerase I 0.0019 0.0017 0.0038
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.0044
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0024 0.0055
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2566 0.494 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.008
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0024 0.019
Echinococcus granulosus expressed conserved protein 0.0293 0.0547 0.1301
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0126 0.0174
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0612 0.1164 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0019 0.0149
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1416 0.2718 1
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0046 0.007 0.0252
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0019 0.0149
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Brugia malayi aldehyde dehydrogenase 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Echinococcus granulosus nibrin 0.0021 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0276 0.038
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0125
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0019 0.0017 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0111 0.0262
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0065 0.0231
Brugia malayi hypothetical protein 0.0043 0.0065 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0084 0.076
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0165
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0134 0.024 0.057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0019 0.0161
Mycobacterium leprae putative cytochrome p450 0.002 0.0019 0.1392
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0081
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.0628
Schistosoma mansoni hypothetical protein 0.0317 0.0593 0.141
Echinococcus multilocularis Niemann Pick C1 protein 0.0445 0.0842 0.1703
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0027
Brugia malayi Cytochrome P450 family protein 0.0029 0.0038 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0019 0.0161
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0022
Brugia malayi Cytochrome P450 family protein 0.0029 0.0038 0.0052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.0353 0.3251
Entamoeba histolytica Ran family GTPase 0.0022 0.0024 0.0374
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0065 0.0174
Schistosoma mansoni cpg binding protein 0.0034 0.0046 0.0106
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0024 0.0053
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0049 0.0068
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0022 0.0074
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0065 0.0089
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0024 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0022
Schistosoma mansoni cpg binding protein 0.0034 0.0046 0.0106
Onchocerca volvulus 0.0022 0.0024 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Schistosoma mansoni hypothetical protein 0.0129 0.023 0.0545
Loa Loa (eye worm) hypothetical protein 0.0473 0.0895 0.6269
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0024 0.1777
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0353 0.0836
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0019 0.0161
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0022 0.0849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Plasmodium vivax importin-beta 2, putative 0.003 0.0039 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Schistosoma mansoni patched 1 0.0134 0.024 0.0567
Schistosoma mansoni hypothetical protein 0.0129 0.023 0.0545
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0081 0.0565
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0065 0.015
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Echinococcus multilocularis snurportin 1 0.0317 0.0593 0.1201
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0019 0.0149
Brugia malayi Aldehyde dehydrogenase protein 4 0.0011 0.0002 0.0002
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.002 0.031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0066
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0155
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.0448
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0027
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0019 0.1392
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0038 0.0265
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0126 1
Brugia malayi TAR-binding protein 0.013 0.0233 0.0321
Schistosoma mansoni tar DNA-binding protein 0.013 0.0233 0.0552
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0019 0.0017 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0002
Brugia malayi Telomerase reverse transcriptase 0.3769 0.7264 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Echinococcus granulosus snurportin 1 0.0317 0.0593 0.1412
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0038 0.0133
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.0044
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0065 0.0174
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0612 0.1164 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0022 0.0347
Trypanosoma brucei unspecified product 0.002 0.002 0.0066
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0125
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0019 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0066
Echinococcus granulosus cpg binding protein 0.0034 0.0046 0.0109
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0097 0.0352
Loa Loa (eye worm) hypothetical protein 0.0748 0.1427 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0019 0.0149
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0024 0.019
Entamoeba histolytica hypothetical protein 0.0114 0.0201 0.3431
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0019 0.0161
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0022 0.0052
Echinococcus multilocularis tar DNA binding protein 0.013 0.0233 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0024 0.019
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.003 0.0039 0.0271
Echinococcus multilocularis 0.002 0.0019 0.0038
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0022 0.0849
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0038 0.0133
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0024 0.019
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0065 0.0174
Brugia malayi RNA binding protein 0.013 0.0233 0.0321
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0066
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0023 0.0025 0.0085
Entamoeba histolytica hypothetical protein 0.0114 0.0201 0.3431
Loa Loa (eye worm) aldehyde dehydrogenase 0.0011 0.0002 0.0012
Schistosoma mansoni hypothetical protein 0.0452 0.0854 0.2031
Loa Loa (eye worm) histone methyltransferase 0.001 0 0.0002
Trichomonas vaginalis ran, putative 0.0022 0.0024 0.0915
Leishmania major GTP-binding protein, putative 0.0022 0.0024 0.008
Schistosoma mansoni hypothetical protein 0.0129 0.023 0.0545
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0046 0.007 0.0252
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0126 0.1071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.0353 0.0713
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0019 0.0045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Brugia malayi hypothetical protein 0.0114 0.0201 0.0277
Echinococcus multilocularis survival motor neuron protein 1 0.0748 0.1427 0.2889
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.0353 0.0839
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0136
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0024 0.0205
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0024 0.0081
Echinococcus multilocularis muscleblind protein 0.0473 0.0895 0.1811
Brugia malayi CHE-14 protein 0.0134 0.024 0.033
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0022
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0024 0.0205
Entamoeba histolytica hypothetical protein 0.0021 0.0022 0.0347
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Loa Loa (eye worm) TAR-binding protein 0.013 0.0233 0.1636
Loa Loa (eye worm) cytochrome P450 0.002 0.0019 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0019 0.0161
Brugia malayi hypothetical protein 0.0748 0.1427 0.1965
Toxoplasma gondii patched family protein 0.0019 0.0018 0.0059
Toxoplasma gondii patched family protein 0.0019 0.0018 0.0059
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0001 0.001
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.002 0.0066
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0011 0.0002 0.0012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0024 0.0167
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0065 0.0174
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0126 0.1071
Echinococcus multilocularis protein dispatched 1 0.0153 0.0276 0.0559
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0001 0.0002
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0024 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0201 0.0407
Leishmania major cytochrome p450-like protein 0.002 0.0019 0.0064
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0024 0.0081
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0019 0.0017 0.0058
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0046 0.007 0.0634
Echinococcus multilocularis nibrin 0.0021 0.0022 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.1096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0126 0.1071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Schistosoma mansoni hypothetical protein 0.0129 0.023 0.0545
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0126 0.1154
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0134 0.024 0.1679
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0038 0.0265
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.002 0.0039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.0353 0.1292
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0024 0.093
Schistosoma mansoni tar DNA-binding protein 0.013 0.0233 0.0552
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.0628
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0011 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0046 0.007 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.024 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.0593 0.4158
Mycobacterium ulcerans 5'-3' exonuclease 0.0046 0.007 0.0588
Leishmania major DNA polymerase eta, putative 0.002 0.002 0.0066
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Brugia malayi topoisomerase 0.0021 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Onchocerca volvulus 0.0019 0.0018 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0126 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0001 0.001
Brugia malayi DKFZp564C0469 protein 0.0021 0.0022 0.003
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0019 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0126 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0126 0.2141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0353 0.3018
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0019 0.0149
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.008
Brugia malayi hypothetical protein 0.0021 0.0022 0.003
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0046 0.007 0.0195
Mycobacterium ulcerans hypothetical protein 0.0075 0.0126 0.1071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0126 0.1071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0019 0.0161
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0569 0.1081 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0081
Echinococcus multilocularis importin subunit beta 1 0.003 0.0039 0.0078
Brugia malayi ecdysteroid receptor 0.001 0.0001 0.0002
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0022 0.0074
Echinococcus granulosus importin subunit beta 1 0.003 0.0039 0.0091
Echinococcus granulosus Niemann Pick C1 protein 0.0445 0.0842 0.2003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Loa Loa (eye worm) RNA binding protein 0.013 0.0233 0.1636
Echinococcus granulosus muscleblind protein 0.0473 0.0895 0.2129
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0065 0.5059
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.009 0.0267
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0126 0.0459
Plasmodium falciparum telomerase reverse transcriptase 0.1416 0.2718 1
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Loa Loa (eye worm) twinkle helicase 0.0014 0.0008 0.0056
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Onchocerca volvulus 0.0019 0.0018 0.0016
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0022 0.0049
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.008
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0024 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Loa Loa (eye worm) hypothetical protein 0.0075 0.0126 0.0885
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0136
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0081
Schistosoma mansoni tar DNA-binding protein 0.013 0.0233 0.0552
Onchocerca volvulus 0.0153 0.0276 0.0275
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0018 0.015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0038 0.031
Schistosoma mansoni hypothetical protein 0.0153 0.0276 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0022 0.0074
Schistosoma mansoni survival motor neuron protein 0.0153 0.0276 0.0654
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0019 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.009 0.0756
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.0628
Echinococcus multilocularis cpg binding protein 0.0034 0.0046 0.0093
Toxoplasma gondii patched family protein 0.0019 0.0018 0.0059
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Schistosoma mansoni ran 0.0022 0.0024 0.0053
Schistosoma mansoni hypothetical protein 0.0035 0.0049 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0022 0.003
Brugia malayi DNA polymerase I family protein 0.0019 0.0017 0.0024
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0065 0.0541
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.002 0.0757
Schistosoma mansoni amine oxidase 0.0043 0.0065 0.015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0001 0.0003
Brugia malayi Patched related family protein 12 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0019 0.0161
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Brugia malayi hypothetical protein 0.0019 0.0018 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0001 0.0003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0024 0.0205
Brugia malayi Muscleblind-like protein 0.0473 0.0895 0.1232
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Echinococcus multilocularis twinkle protein, mitochondrial 0.0014 0.0008 0.0016
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0066
Brugia malayi Cytochrome P450 family protein 0.0062 0.0101 0.0138
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.1777
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Onchocerca volvulus 0.0022 0.0024 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0065 0.015
Onchocerca volvulus 0.0021 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0001 0.0002
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Brugia malayi Patched related family protein 10 0.0019 0.0018 0.0024
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0011 0.0002 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0134 0.024 0.057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0065 0.0174
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0068 0.0245
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.0628
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.0628
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0019 0.0017 0.0058
Echinococcus multilocularis GPCR, family 2 0.0016 0.0013 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0065 0.0174
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1416 0.2718 1
Echinococcus granulosus GPCR family 2 0.0016 0.0013 0.003
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0065 0.0153
Echinococcus multilocularis dnaJ subfamily B 0.0452 0.0854 0.1729
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0126 0.0459
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0024 0.008
Echinococcus multilocularis expressed conserved protein 0.0293 0.0547 0.1106
Onchocerca volvulus 0.0019 0.0018 0.0016
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0024 0.0081
Schistosoma mansoni topbp1 0.0021 0.0022 0.0049
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0019 0.0161
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0011 0.0002 0.0002
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0164 0.0298 0.2086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.009 0.8024
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0019 0.0161
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.002 0.0046
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0019 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0081 0.0111
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0019 0.0149
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.003
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0024 0.019
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0022 0.0849
Leishmania major telomerase reverse transcriptase, putative 0.1416 0.2718 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0065 0.013
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0024 0.019
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0043 0.0298
Schistosoma mansoni amine oxidase 0.0043 0.0065 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Echinococcus multilocularis sterol regulatory element binding protein 0.0134 0.024 0.0485
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0101 0.0704
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Entamoeba histolytica hypothetical protein 0.0114 0.0201 0.3431
Schistosoma mansoni hypothetical protein 0.0114 0.0201 0.0476
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0019 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0002
Echinococcus multilocularis dna polymerase kappa 0.002 0.002 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0126 0.1154
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0312 0.0583 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.002 0.0757
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0065 0.0106 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0065 0.0583
Schistosoma mansoni cytochrome P450 0.002 0.0019 0.0042
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0014 0.0008 0.0007
Mycobacterium ulcerans DNA polymerase I 0.0065 0.0106 0.0899
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0019 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0084 0.076
Brugia malayi steroid hormone receptor 0.001 0.0001 0.0002
Onchocerca volvulus Protein patched homolog 0.0019 0.0018 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0089
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0046 0.007 0.0252
Echinococcus granulosus dna polymerase kappa 0.002 0.002 0.0046
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0024 0.1777
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0084 0.076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0001 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.1096
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0353 0.0836
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0126 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0019 0.0161
Toxoplasma gondii patched family protein 0.0019 0.0018 0.0059
Onchocerca volvulus 0.0022 0.0024 0.0022
Brugia malayi cytochrome P450 0.002 0.0019 0.0026
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0019 0.0149
Brugia malayi hypothetical protein 0.0019 0.0018 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0019 0.0149
Trichomonas vaginalis DNA polymerase I, putative 0.0019 0.0017 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0065 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0024 0.019
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0032
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0024 0.0056
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0039 0.0136
Brugia malayi CXXC zinc finger family protein 0.0032 0.0043 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Plasmodium vivax patched family protein, putative 0.0019 0.0018 0.0001
Echinococcus multilocularis dna polymerase eta 0.002 0.002 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0353 0.3018
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0022 0.0849
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0019 0.0017 0.0058
Loa Loa (eye worm) oxidoreductase 0.0022 0.0024 0.0167
Leishmania major cytochrome p450-like protein 0.0029 0.0038 0.0133
Onchocerca volvulus 0.0019 0.0018 0.0016
Mycobacterium ulcerans dehydrogenase 0.0043 0.0065 0.0541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Toxoplasma gondii RNA-directed DNA polymerase 0.1416 0.2718 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0001 0.0002
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0065 0.5049
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0019 0.0161
Mycobacterium ulcerans oxidoreductase 0.0043 0.0065 0.0541
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0154
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0201 0.0479
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0065 0.0541
Loa Loa (eye worm) hypothetical protein 0.0075 0.0126 0.0885
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0353 0.3018
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0453
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0011 0.0002 0.0003
Brugia malayi nuclear receptor NHR-88 0.001 0.0001 0.0002
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0022 0.1931
Loa Loa (eye worm) hypothetical protein 0.0134 0.024 0.1679
Brugia malayi Niemann-Pick C1 protein precursor 0.0312 0.0583 0.0803
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0024 0.0047
Brugia malayi Myosin head containing protein 0.0019 0.0018 0.0024
Onchocerca volvulus 0.0043 0.0065 0.0063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0019 0.0161
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0081 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0126 0.1071
Brugia malayi Patched protein homolog 1 0.0019 0.0018 0.0024
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0125
Schistosoma mansoni cpg binding protein 0.0032 0.0043 0.0098
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0065 0.0231
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0011 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0473 0.0895 0.6269
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.0138
Giardia lamblia Telomerase catalytic subunit 0.1416 0.2718 1
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0066
Brugia malayi Importin beta-1 subunit 0.003 0.0039 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.2184 0.4201 0.8504
Plasmodium falciparum importin beta, putative 0.003 0.0039 0.0078
Brugia malayi RNA, U transporter 1 0.0084 0.0144 0.0199
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0065 0.0106 0.0969
Leishmania major DNA polymerase kappa, putative 0.002 0.002 0.0066
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0126 0.2141
Brugia malayi hypothetical protein 0.0021 0.0022 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.009 0.0267
Brugia malayi hypothetical protein 0.0019 0.0018 0.0024
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0024 0.0205
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0001 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0024 0.0167
Echinococcus granulosus tar DNA binding protein 0.013 0.0233 0.0555
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0019 0.0149
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0022 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0019 0.0161
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.0022 0.1621
Schistosoma mansoni ran 0.0022 0.0024 0.0053
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0019 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0233 0.0321
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0019 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0126 0.0174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0126 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0024 0.0033
Schistosoma mansoni tar DNA-binding protein 0.013 0.0233 0.0552
Onchocerca volvulus 0.0075 0.0126 0.0125
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0024 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.002 0.0066
Echinococcus granulosus twinkle protein mitochondrial 0.0014 0.0008 0.0018
Plasmodium vivax telomerase reverse transcriptase, putative 0.1416 0.2718 1
Brugia malayi Patched family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0125
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0024 0.093
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0022 0.0849
Echinococcus multilocularis protein patched 0.0134 0.024 0.0485

Activities

Activity type Activity value Assay description Source Reference
Log 1/MEC (functional) = 0.48 Minimum effective concentration for anti-coccidial activity against oocytes of coccidian parasite Eimeria tenella in chicks expressed as mmol/kg of feed ChEMBL. 1635056
Log 1/MEC (functional) = 0.48 Tested for anti-coccidial activity ChEMBL. 8411009
MEC (functional) = 125 p.p.m. Minimum effective concentration in feed to protect chickens against infections caused by Eimeria tenella ChEMBL. 6895527
MEC (functional) = 125 p.p.m. Minimum effective concentration (MEC) value was determined as a measure of anti-coccidial activity (MEC is expressed as mmol/kg of feed). ChEMBL. 2061927

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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