Detailed information for compound 39161

Basic information

Technical information
  • TDR Targets ID: 39161
  • Name: 6-chloro-2-(4-methylpiperazin-1-yl)-5-methyls ulfanylpyrimidin-4-amine
  • MW: 273.786 | Formula: C10H16ClN5S
  • H donors: 1 H acceptors: 2 LogP: 1.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1c(N)nc(nc1Cl)N1CCN(CC1)C
  • InChi: 1S/C10H16ClN5S/c1-15-3-5-16(6-4-15)10-13-8(11)7(17-2)9(12)14-10/h3-6H2,1-2H3,(H2,12,13,14)
  • InChiKey: AQNXEGXXMPANLU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-2-(4-methylpiperazin-1-yl)-5-methylsulfanyl-pyrimidin-4-amine
  • 6-chloro-2-(4-methyl-1-piperazinyl)-5-(methylthio)-4-pyrimidinamine
  • [6-chloro-2-(4-methylpiperazino)-5-(methylthio)pyrimidin-4-yl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References
Rattus norvegicus Dopamine receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine receptor   475 aa 405 aa 33.3 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine receptor   475 aa 398 aa 34.2 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0114 0.0858 0.0818
Trypanosoma cruzi major cysteine proteinase, putative 0.014 0.1101 0.1101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0599 0.1218
Leishmania major cathepsin L-like protease 0.0377 0.3328 0.3328
Trypanosoma brucei kinesin, putative 0.0045 0.0208 0.0165
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0294 0.255 0.255
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0114 0.0858 0.0853
Trypanosoma cruzi histone deacetylase, putative 0.0677 0.6148 0.6148
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.3831 0.3831
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0136 0.0152
Toxoplasma gondii preprocathepsin c precursor, putative 0.0086 0.0599 0.0558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0086 0.0599 0.0594
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Plasmodium vivax unspecified product 0.0086 0.0599 0.091
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0546 0.4916 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0064 0.0389 0.0384
Plasmodium falciparum plasmepsin II 0.005 0.0252 0.0342
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0086 0.0599 0.091
Toxoplasma gondii histone deacetylase HDAC3 0.0546 0.4916 0.4894
Brugia malayi hypothetical protein 0.0231 0.1954 0.1919
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0114 0.0858 0.0853
Trypanosoma brucei histone deacetylase 1 0.0546 0.4916 0.4894
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.2222 0.4519
Mycobacterium tuberculosis Conserved protein 0.0106 0.0779 0.0732
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0064 0.0389 0.0389
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.1624 0.162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Giardia lamblia Alanyl dipeptidyl peptidase 0.0114 0.0858 0.151
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.2401 0.2401
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0043 0.0038
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0086 0.0599 0.0969
Echinococcus multilocularis cathepsin L cysteine protease 0.0377 0.3328 0.3325
Echinococcus granulosus histone deacetylase 6 0.0677 0.6148 0.6146
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0178 0.1455 0.1451
Brugia malayi cathepsin Z-like cysteine proteinase 0.0086 0.0599 0.0558
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0054 0.0297 0.0603
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1705 0.1701
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Brugia malayi Histone deacetylase family protein 0.0677 0.6148 0.6131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0389
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0675 0.6129 0.6816
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0294 0.255 0.255
Trypanosoma cruzi oligopeptidase b 0.0432 0.3848 0.3848
Brugia malayi PHD-finger family protein 0.0028 0.0052 0.0009
Echinococcus granulosus histone deacetylase 8 0.0278 0.2401 0.2397
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Loa Loa (eye worm) histone deacetylase 3 0.0546 0.4916 0.4913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0254 0.0249
Onchocerca volvulus 0.0047 0.0228 0.0186
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0136 0.0093
Onchocerca volvulus 0.0377 0.3328 0.3299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0054 0.0297 0.0254
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0599 0.1218
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.017 0.1383 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0294 0.255 0.5186
Echinococcus granulosus histone deacetylase 3 0.0546 0.4916 0.4914
Leishmania major histone deacetylase, putative 0.0546 0.4916 0.4916
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.0779 0.0732
Plasmodium falciparum serine repeat antigen 6 0.0086 0.0599 0.091
Toxoplasma gondii cathepsin CPC1 0.0086 0.0599 0.0558
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0114 0.0858 0.0853
Echinococcus multilocularis histone deacetylase 3 0.0546 0.4916 0.4914
Echinococcus multilocularis calpain 0.0064 0.0389 0.0384
Trypanosoma cruzi histone deacetylase 1, putative 0.0546 0.4916 0.4916
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0054 0.0297 0.0291
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0114 0.0858 0.0858
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0054 0.0297 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Brugia malayi hypothetical protein 0.0052 0.0274 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Plasmodium falciparum importin beta, putative 0.0028 0.005 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1705 0.3469
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0424 0.0419
Onchocerca volvulus 0.0106 0.0779 0.0739
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0086 0.0599 0.1218
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0114 0.0858 0.0851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0599 0.0558
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0599 0.0593
Brugia malayi cathepsin L-like cysteine proteinase 0.0086 0.0599 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0758 0.6906 0.6904
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0858 0.0818
Trypanosoma cruzi histone deacetylase 1, putative 0.0546 0.4916 0.4916
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Toxoplasma gondii histone deacetylase HDAC4 0.0278 0.2401 0.2368
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0086 0.0599 0.091
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Leishmania major cathepsin L-like protease 0.0377 0.3328 0.3328
Giardia lamblia Histone deacetylase 0.0546 0.4916 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0377 0.3328 0.3325
Loa Loa (eye worm) hypothetical protein 0.0546 0.4916 0.4913
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1705 0.1701
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0432 0.3848 0.3848
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.0779 0.0732
Schistosoma mansoni histone deacetylase 4 5 0.0677 0.6148 0.6146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0086 0.0599 0.0594
Toxoplasma gondii cathepsin B 0.0294 0.255 0.2517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Echinococcus granulosus histone deacetylase 7 0.0677 0.6148 0.6146
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0779 0.1585
Loa Loa (eye worm) hypothetical protein 0.1087 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0086 0.0599 0.091
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Trypanosoma brucei prolyl oligopeptidase, putative 0.0432 0.3848 0.3821
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0054 0.0297 0.0291
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0758 0.6906 0.6904
Loa Loa (eye worm) histone deacetylase 11 0.0278 0.2401 0.2396
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0546 0.4916 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0086 0.0599 0.091
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Echinococcus granulosus histone deacetylase 6 0.0677 0.6148 0.6146
Leishmania major kinesin, putative 0.0045 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Plasmodium falciparum plasmepsin IV 0.005 0.0252 0.0342
Toxoplasma gondii hypothetical protein 0.0114 0.0858 0.0818
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0377 0.3328 0.5381
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0136 0.0093
Schistosoma mansoni cathepsin B (C01 family) 0.0086 0.0599 0.0594
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0054 0.0297 0.029
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Loa Loa (eye worm) histone deacetylase 1 0.0546 0.4916 0.4913
Loa Loa (eye worm) hypothetical protein 0.0259 0.2222 0.2217
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0054 0.0297 0.029
Schistosoma mansoni inositol monophosphatase 0.0156 0.1249 0.1245
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0037
Echinococcus granulosus geminin 0.0184 0.152 0.1515
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0274 0.0379
Onchocerca volvulus 0.0241 0.205 0.2015
Plasmodium falciparum histone deacetylase 1 0.0546 0.4916 0.7982
Echinococcus multilocularis histone deacetylase 1 0.0546 0.4916 0.4914
Trypanosoma cruzi metacaspase, putative 0.0027 0.0043 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0136 0.0136
Entamoeba histolytica cysteine protease, putative 0.0377 0.3328 0.677
Giardia lamblia Hypothetical protein 0.0086 0.0599 0.0969
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0054 0.0297 0.0415
Plasmodium falciparum serine repeat antigen 4 0.0086 0.0599 0.091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0072 0.0066
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Echinococcus granulosus calpain A 0.0178 0.1455 0.1451
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0054 0.0297 0.0603
Echinococcus granulosus cathepsin b 0.0758 0.6906 0.6904
Giardia lamblia Cathepsin B precursor 0.0294 0.255 0.5049
Brugia malayi cathepsin L-like precursor 0.0259 0.2222 0.2188
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Onchocerca volvulus 0.0377 0.3328 0.3299
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0779 0.1585
Schistosoma mansoni calpain-7 (C02 family) 0.0064 0.0389 0.0384
Trichomonas vaginalis inositol monophosphatase, putative 0.0156 0.1249 0.2541
Brugia malayi Histone deacetylase 1 0.0546 0.4916 0.4894
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.3831 0.3831
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.0779 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0086 0.0599 0.1218
Trichomonas vaginalis brca1-associated protein, putative 0.0054 0.0297 0.0603
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0424 0.0419
Giardia lamblia Hypothetical protein 0.0086 0.0599 0.0969
Loa Loa (eye worm) hypothetical protein 0.0278 0.2401 0.2396
Trypanosoma brucei oligopeptidase b 0.0432 0.3848 0.3821
Plasmodium vivax unspecified product 0.0118 0.0893 0.1392
Entamoeba histolytica histone deacetylase, putative 0.0546 0.4916 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0043 0.0038
Onchocerca volvulus Cathepsin L homolog 0.0377 0.3328 0.3299
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0054 0.0297 0.0415
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0086 0.0599 0.091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0377 0.3328 0.3325
Echinococcus multilocularis hypothetical protein 0.0064 0.0389 0.0384
Brugia malayi cathepsin L precursor 0.0086 0.0599 0.0558
Plasmodium vivax SET domain protein, putative 0.003 0.0072 0.0046
Loa Loa (eye worm) hypothetical protein 0.0259 0.2222 0.2217
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0072 0.0066
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0054 0.0297 0.0297
Echinococcus granulosus cathepsin L 0.0204 0.1705 0.1701
Plasmodium vivax serine-repeat antigen (SERA) 0.0086 0.0599 0.091
Loa Loa (eye worm) hypothetical protein 0.0758 0.6906 0.6904
Giardia lamblia Cathepsin B precursor 0.0086 0.0599 0.0969
Leishmania major histone deacetylase, putative 0.0546 0.4916 0.4916
Plasmodium falciparum serine repeat antigen 7 0.0086 0.0599 0.091
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1087 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0599 0.0558
Giardia lamblia Alanyl dipeptidyl peptidase 0.0114 0.0858 0.151
Plasmodium falciparum serine repeat antigen 1 0.0086 0.0599 0.091
Loa Loa (eye worm) hypothetical protein 0.0231 0.1954 0.1948
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0174 0.142 0.1383
Plasmodium falciparum cysteine proteinase falcipain 3 0.0377 0.3328 0.5381
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0432 0.3848 0.3848
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Entamoeba histolytica cysteine proteinase 2 0.0204 0.1705 0.3469
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0114 0.0858 0.0818
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0118 0.0893 0.0853
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0086 0.0599 0.0594
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0114 0.0858 0.1744
Plasmodium falciparum serine repeat antigen 8 0.0086 0.0599 0.091
Leishmania major hypothetical protein, conserved 0.0054 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Plasmodium falciparum plasmepsin VI 0.005 0.0252 0.0342
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0054 0.0297 0.0254
Brugia malayi Pre-SET motif family protein 0.003 0.0072 0.0028
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0054 0.0297 0.0254
Trypanosoma brucei histone deacetylase 2 0.0278 0.2401 0.2368
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Schistosoma mansoni cathepsin F (C01 family) 0.0377 0.3328 0.3325
Echinococcus multilocularis histone deacetylase 6 0.0677 0.6148 0.6146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1624 0.162
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0043 0.0038
Brugia malayi histone deacetylase 1 (HD1) 0.0546 0.4916 0.4894
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0054 0.0297 0.0254
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.0779 0.0732
Leishmania major oligopeptidase b 0.0432 0.3848 0.3848
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0779 0.0779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0254 0.0249
Leishmania major histone deacetylase, putative 0.0677 0.6148 0.6148
Toxoplasma gondii histone deacetylase HDAC2 0.0546 0.4916 0.4894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0136 0.0136
Echinococcus multilocularis histone deacetylase 0.0677 0.6148 0.6146
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0114 0.0858 0.0853
Trichomonas vaginalis esterase, putative 0.0106 0.0779 0.1585
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0297 0.0415
Brugia malayi follicle stimulating hormone receptor 0.0253 0.2161 0.2127
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Loa Loa (eye worm) cathepsin B 0.0294 0.255 0.2545
Brugia malayi Bromodomain containing protein 0.0044 0.0195 0.0153
Echinococcus multilocularis histone deacetylase 7 0.0677 0.6148 0.6146
Onchocerca volvulus 0.0377 0.3328 0.3299
Echinococcus multilocularis acylamino acid releasing enzyme 0.0114 0.0858 0.0853
Entamoeba histolytica protein kinase, putative 0.0045 0.0208 0.0422
Trypanosoma brucei cysteine peptidase C (CPC) 0.0294 0.255 0.2517
Onchocerca volvulus 0.0377 0.3328 0.3299
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0377 0.3328 0.677
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0432 0.3848 0.3821
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0274 0.0232
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0156 0.1249 0.2541
Brugia malayi cathepsin F-like cysteine proteinase 0.0086 0.0599 0.0558
Brugia malayi calpain family protein 1 0.017 0.1383 0.1346
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0054 0.0297 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Giardia lamblia Encystation-specific protease 0.0086 0.0599 0.0969
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Echinococcus multilocularis cysteine protease 0.0377 0.3328 0.3325
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0779 0.1585
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0043 0.0043
Echinococcus granulosus cathepsin L 0.0086 0.0599 0.0594
Echinococcus granulosus cathepsin l1 0.0377 0.3328 0.3325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1705 0.3469
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0086 0.0599 0.091
Plasmodium falciparum histone deacetylase, putative 0.0677 0.6148 1
Loa Loa (eye worm) calpain family protein 1 0.017 0.1383 0.1377
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0599 0.1218
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0054 0.0297 0.0415
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.0779 0.0774
Echinococcus granulosus caspase 0.0027 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0453 0.4044 0.404
Echinococcus granulosus caspase 2 0.0027 0.0043 0.0038
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1705 0.1705
Echinococcus multilocularis histone deacetylase 6 0.0731 0.6658 0.6657
Giardia lamblia Cathepsin B precursor 0.0294 0.255 0.5049
Loa Loa (eye worm) aspartic protease BmAsp-2 0.005 0.0252 0.0245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0779 0.0774
Echinococcus multilocularis caspase 2 0.0027 0.0043 0.0038
Echinococcus multilocularis cathepsin b 0.0758 0.6906 0.6904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Toxoplasma gondii histone deacetylase HDAC5 0.0278 0.2401 0.2368
Trypanosoma brucei histone deacetylase 4 0.0677 0.6148 0.6131
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0054 0.0297 0.0415
Plasmodium vivax vivapain-1 0.0204 0.1705 0.2723
Leishmania major cathepsin L-like protease 0.043 0.3831 0.3831
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0377 0.3328 0.3325
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0758 0.6906 0.6906
Giardia lamblia Cysteine protease 0.0086 0.0599 0.0969
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1249 0.1211
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Plasmodium vivax vivapain-3 0.0204 0.1705 0.2723
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1249 0.1249
Loa Loa (eye worm) calpain 5 0.0045 0.0208 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0252 0.0247
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Trypanosoma brucei prolyl endopeptidase 0.1087 1 1
Schistosoma mansoni bromodomain containing protein 0.0072 0.0462 0.0457
Echinococcus granulosus acylamino acid releasing enzyme 0.0114 0.0858 0.0853
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0779 0.1206
Schistosoma mansoni hypothetical protein 0.0184 0.152 0.1515
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0858 0.0858
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0254 0.0249
Plasmodium vivax vivapain-2 0.0377 0.3328 0.5381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1705 0.1669
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0114 0.0858 0.0818
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.0779 0.1733
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.0779 0.0773
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0114 0.0858 0.1744
Schistosoma mansoni histone deacetylase hda2 0.0731 0.6658 0.6657
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.017 0.0165
Loa Loa (eye worm) calpain 0.0064 0.0389 0.0382
Toxoplasma gondii histone deacetylase HDAC1 0.0677 0.6148 0.6131
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Brugia malayi hypothetical protein 0.0034 0.0101 0.0059
Giardia lamblia Cathepsin B precursor 0.0086 0.0599 0.0969
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.255 0.2546
Loa Loa (eye worm) prolyl oligopeptidase 0.0114 0.0858 0.0851
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0389
Schistosoma mansoni ap endonuclease 0.0037 0.0136 0.0131
Leishmania major hypothetical protein, conserved 0.0052 0.0274 0.0274
Plasmodium vivax vivapain-2 0.0377 0.3328 0.5381
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0043 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0054 0.0297 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Echinococcus multilocularis cysteine protease 0.0377 0.3328 0.3325
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Brugia malayi Importin beta-1 subunit 0.0028 0.005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0399 0.3533 0.3529
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0027 0.0022
Brugia malayi cathepsin F-like cysteine proteinase 0.0118 0.0893 0.0853
Echinococcus multilocularis cathepsin b 0.0758 0.6906 0.6904
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Leishmania major cathepsin L-like protease 0.043 0.3831 0.3831
Echinococcus granulosus histone deacetylase 1 0.0546 0.4916 0.4914
Plasmodium vivax importin-beta 2, putative 0.0028 0.005 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.0779 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0779 0.0779
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0858 0.0858
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0377 0.3328 0.677
Echinococcus multilocularis importin subunit beta 1 0.0028 0.005 0.0045
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0178 0.1455 0.1451
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Onchocerca volvulus 0.0086 0.0599 0.0558
Echinococcus granulosus snurportin 1 0.0299 0.26 0.2596
Brugia malayi beta-lactamase family protein 0.0106 0.0779 0.0739
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0274 0.0232
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Onchocerca volvulus 0.0106 0.0779 0.0739
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.26 0.2595
Loa Loa (eye worm) hypothetical protein 0.0114 0.0858 0.0851
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0178 0.1455 0.1451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1249 0.2541
Plasmodium falciparum histone deacetylase 2 0.0677 0.6148 1
Loa Loa (eye worm) cysteine protease 0.0377 0.3328 0.3324
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0054 0.0297 0.0603
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0086 0.0599 0.0594
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0599 0.0558
Schistosoma mansoni hypothetical protein 0.0299 0.26 0.2596
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0054 0.0297 0.0297
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0114 0.0858 0.0853
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0086 0.0599 0.0594
Brugia malayi Inositol-1 0.0156 0.1249 0.1211
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1705 0.3469
Brugia malayi cathepsin Z-like cysteine proteinase 0.0086 0.0599 0.0558
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.0779 0.0732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Schistosoma mansoni brca1-associated protein (brap2) 0.0054 0.0297 0.0291
Trypanosoma cruzi prolyl endopeptidase 0.1087 1 1
Schistosoma mansoni importin beta-1 0.0028 0.005 0.0045
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0114 0.0858 0.1744
Echinococcus granulosus caspase 8 0.0027 0.0043 0.0038
Toxoplasma gondii cathepsin CPC2 0.0086 0.0599 0.0558
Schistosoma mansoni cathepsin D (A01 family) 0.0146 0.1159 0.1155
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0054 0.0297 0.0291
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0432 0.3848 0.3848
Leishmania major cathepsin L-like protease 0.0377 0.3328 0.3328
Echinococcus multilocularis histone deacetylase 8 0.0278 0.2401 0.2397
Brugia malayi Cathepsin L-like precursor 0.0259 0.2222 0.2188
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0274 0.0274
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1705 0.1705
Plasmodium vivax calpain, putative 0.0064 0.0389 0.0566
Echinococcus granulosus cathepsin L cysteine protease 0.0204 0.1705 0.1701
Entamoeba histolytica hypothetical protein, conserved 0.0114 0.0858 0.1744
Schistosoma mansoni survival motor neuron protein 0.0047 0.0228 0.0223
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.2401 0.2401
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0274 0.0379
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.0235
Entamoeba histolytica cysteine proteinase, putative 0.0377 0.3328 0.677
Onchocerca volvulus Cathepsin F homolog 0.0377 0.3328 0.3299
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0086 0.0599 0.0593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0758 0.6906 0.6904
Echinococcus granulosus histone deacetylase 0.0677 0.6148 0.6146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Mycobacterium tuberculosis Conserved protein 0.0106 0.0779 0.0732
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0086 0.0599 0.091
Echinococcus granulosus calpain 0.0064 0.0389 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0599 0.1218
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0114 0.0858 0.0818
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Brugia malayi RNA, U transporter 1 0.008 0.0536 0.0495
Plasmodium falciparum serine repeat antigen 2 0.0086 0.0599 0.091
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0858 0.1744
Echinococcus granulosus cysteine protease 0.0204 0.1705 0.1701
Plasmodium falciparum serine repeat antigen 3 0.0086 0.0599 0.091
Schistosoma mansoni histone deacetylase hda2 0.0278 0.2401 0.2397
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1705 0.1669
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0118 0.0893 0.0887
Schistosoma mansoni hypothetical protein 0.0184 0.152 0.1515
Schistosoma mansoni cathepsin S (C01 family) 0.0086 0.0599 0.0594
Schistosoma mansoni histone deacetylase 0.0546 0.4916 0.4914
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1705 0.1669
Loa Loa (eye worm) histone deacetylase 7A 0.0677 0.6148 0.6145
Echinococcus granulosus cathepsin l cysteine peptidase 0.0377 0.3328 0.3325
Entamoeba histolytica calpain large subunit domain III containing protein 0.0045 0.0208 0.0422
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0136 0.0276
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0432 0.3848 0.4222
Brugia malayi BRCA1-associated protein 2 containing protein 0.0054 0.0297 0.0254
Loa Loa (eye worm) hypothetical protein 0.005 0.0254 0.0247
Trypanosoma brucei histone deacetylase, putative 0.0677 0.6148 0.6131
Schistosoma mansoni histone deacetylase 0.0546 0.4916 0.4914
Loa Loa (eye worm) ctsf protein 0.0377 0.3328 0.3324
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0389 0.0347
Echinococcus granulosus cathepsin b 0.0758 0.6906 0.6904
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0054 0.0297 0.0291
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.005 0.0252 0.0247
Schistosoma mansoni calpain C (C02 family) 0.0064 0.0389 0.0384
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.005 0.0252 0.0512
Schistosoma mansoni brca1-associated protein (brap2) 0.0054 0.0297 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0086 0.0599 0.091
Trypanosoma cruzi histone deacetylase, putative 0.0677 0.6148 0.6148
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0599 0.0593
Loa Loa (eye worm) hypothetical protein 0.0125 0.0962 0.0956
Onchocerca volvulus Histone deacetylase 10 homolog 0.0278 0.2401 0.2368
Brugia malayi histone deacetylase 11 0.0278 0.2401 0.2368
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0389 0.0347
Toxoplasma gondii prolyl endopeptidase 0.1087 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0086 0.0599 0.0558
Schistosoma mansoni cathepsin D (A01 family) 0.0146 0.1159 0.1155
Echinococcus granulosus prolyl endopeptidase 0.1087 1 1
Echinococcus granulosus calpain 7 C02 family 0.0064 0.0389 0.0384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.1624 0.162
Trichomonas vaginalis set domain proteins, putative 0.0241 0.205 0.4169
Echinococcus granulosus BRCA1 associated protein 0.0054 0.0297 0.0291
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0086 0.0599 0.0969
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0779 0.1585
Loa Loa (eye worm) hypothetical protein 0.0052 0.0274 0.0268
Plasmodium vivax aspartyl proteinase, putative 0.005 0.0252 0.0342
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0054 0.0297 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0599 0.1218
Loa Loa (eye worm) hypothetical protein 0.0106 0.0781 0.0775
Brugia malayi Pre-SET motif family protein 0.0212 0.1775 0.1739
Loa Loa (eye worm) fibroinase 0.0377 0.3328 0.3324
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0139 0.1096 0.1092
Brugia malayi Cathepsin L-like precursor 0.0377 0.3328 0.3299
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0136 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1705 0.3469
Entamoeba histolytica hypothetical protein 0.0086 0.0599 0.1218
Onchocerca volvulus Cathepsin L homolog 0.0377 0.3328 0.3299
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0086 0.0599 0.091
Toxoplasma gondii aspartyl protease ASP1 0.005 0.0252 0.021
Trypanosoma cruzi kinesin, putative 0.0045 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.1624 0.1619
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1705 0.1701
Brugia malayi Cathepsin L-like cysteine proteinase 0.0259 0.2222 0.2188
Trypanosoma cruzi cruzipain precursor, putative 0.0118 0.0893 0.0893
Loa Loa (eye worm) hypothetical protein 0.008 0.0542 0.0535
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0086 0.0599 0.1218
Leishmania major histone deacetylase, putative 0.0677 0.6148 0.6148
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0061 0.0056
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0086 0.0599 0.091
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1705 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Plasmodium falciparum serine repeat antigen 9 0.0086 0.0599 0.091
Brugia malayi cathepsin B-like cysteine proteinase 0.0758 0.6906 0.6892
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0086 0.0599 0.0969
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1705 0.3469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Entamoeba histolytica cysteine proteinase 1, putative 0.0204 0.1705 0.3469
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0858 0.1744
Plasmodium vivax histone deacetylase, putative 0.0278 0.2401 0.3862
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0779 0.1585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1624 0.162
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0086 0.0599 0.091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.2222 0.4519
Leishmania major cathepsin L-like protease 0.0377 0.3328 0.3328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0114 0.0858 0.0853
Onchocerca volvulus 0.0106 0.0779 0.0739
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1954 0.1949
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.017 0.0165
Loa Loa (eye worm) hypothetical protein 0.005 0.0252 0.0245
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0136 0.0131
Giardia lamblia Cysteine protease 0.0086 0.0599 0.0969
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0114 0.0858 0.0858
Trypanosoma cruzi histone deacetylase, putative 0.0677 0.6148 0.6148
Echinococcus granulosus cathepsin l1 0.0259 0.2222 0.2218
Plasmodium vivax unspecified product 0.0204 0.1705 0.2723
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0114 0.0858 0.1744
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0086 0.0599 0.0594
Trichomonas vaginalis histone deacetylase, putative 0.0546 0.4916 1
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0054 0.0297 0.0291
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.1624 0.1588
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0858 0.1744
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1087 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0858 0.0818
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0546 0.4916 1
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0054 0.0297 0.0254
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0054 0.0297 0.029
Schistosoma mansoni inositol monophosphatase 0.0156 0.1249 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0054 0.0297 0.029
Brugia malayi Histone deacetylase family protein 0.0677 0.6148 0.6131
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.0779 0.0739
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0054 0.0297 0.0254
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0156 0.1249 1
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Mycobacterium ulcerans lipase LipD 0.0106 0.0779 0.1733
Onchocerca volvulus 0.0377 0.3328 0.3299
Onchocerca volvulus 0.0259 0.2222 0.2188
Echinococcus multilocularis prolyl endopeptidase 0.1087 1 1
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0054 0.0297 0.0254
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.3831 0.3831
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.1624 0.162
Leishmania major hypothetical protein, conserved 0.0054 0.0297 0.0297
Echinococcus multilocularis inositol monophosphatase 1 0.0156 0.1249 0.1245
Onchocerca volvulus 0.0377 0.3328 0.3299
Plasmodium vivax histone deacetylase 1, putative 0.0546 0.4916 0.7982
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0858 0.1334
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0054 0.0297 0.0336
Echinococcus multilocularis calpain family protein 1, d 0.0125 0.0962 0.0957
Giardia lamblia Hypothetical protein 0.0054 0.0297 0.0336
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.2161 0.2156
Leishmania major cysteine peptidase A (CPA) 0.0377 0.3328 0.3328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.2222 0.4519
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0136 0.0136
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0156 0.1249 0.2999
Trypanosoma cruzi cysteine peptidase, putative 0.0377 0.3328 0.3328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0072 0.0028
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0054 0.0297 0.0603
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Onchocerca volvulus Prolyl endopeptidase homolog 0.1087 1 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Brugia malayi beta-lactamase family protein 0.0106 0.0779 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1249 0.1249
Echinococcus multilocularis calpain A 0.0178 0.1455 0.1451
Giardia lamblia Cathepsin L precursor 0.0086 0.0599 0.0969
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Echinococcus granulosus cathepsin L cysteine proteinase 0.0377 0.3328 0.3325
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0054 0.0297 0.0291
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0313 0.2724 0.2724
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0054 0.0297 0.0291
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.017 0.1383 0.1377
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0758 0.6906 0.6904
Plasmodium falciparum serine repeat antigen 5 0.0086 0.0599 0.091
Plasmodium vivax plasmepsin IV, putative 0.005 0.0252 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Brugia malayi Cathepsin L-like precursor 0.0259 0.2222 0.2188
Schistosoma mansoni hypothetical protein 0.0047 0.0228 0.0223
Echinococcus granulosus importin subunit beta 1 0.0028 0.005 0.0045
Giardia lamblia Cathepsin B precursor 0.0086 0.0599 0.0969
Plasmodium falciparum plasmepsin I 0.005 0.0252 0.0342
Loa Loa (eye worm) hypothetical protein 0.0118 0.0893 0.0887
Brugia malayi calpain 5 0.0045 0.0208 0.0165
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0043 0.0043
Loa Loa (eye worm) inositol-1 0.0156 0.1249 0.1243
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1705 0.1705
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0086 0.0599 0.1218
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Echinococcus multilocularis caspase 8 0.0027 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0151 0.1202 0.1196
Echinococcus multilocularis calpain 7 (C02 family) 0.0064 0.0389 0.0384
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1954 0.1949
Brugia malayi calpain 7 0.0064 0.0389 0.0347
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.0893 0.0893
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Onchocerca volvulus 0.0106 0.0781 0.0741
Schistosoma mansoni calpain-7 (C02 family) 0.0064 0.0389 0.0384
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0114 0.0858 0.0818
Brugia malayi calpain family protein 1 0.017 0.1383 0.1346
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0389 0.0347
Schistosoma mansoni cathepsin C 0.0086 0.0599 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0086 0.0599 0.1218
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.005 0.0252 0.021
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0599 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0043 0.0088
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.0779 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0779 0.0739
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0178 0.1455 0.1451
Schistosoma mansoni cathepsin s 0.0118 0.0893 0.0888
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0054 0.0297 0.0415
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0043 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Giardia lamblia Cysteine protease 0.0086 0.0599 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0858 0.1744
Mycobacterium tuberculosis Probable peptidase 0.0432 0.3848 0.4222
Toxoplasma gondii cathepsin CPL 0.0377 0.3328 0.3299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0054 0.0297 0.029
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0432 0.3848 1
Echinococcus multilocularis cathepsin L 0.0204 0.1705 0.1701
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0156 0.1249 0.1211
Entamoeba histolytica cysteine protease, putative 0.0086 0.0599 0.1218
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0086 0.0599 0.0594
Loa Loa (eye worm) histone deacetylase 0.0677 0.6148 0.6145
Trypanosoma cruzi major cysteine proteinase, putative 0.0086 0.0599 0.0599
Trypanosoma cruzi metacaspase, putative 0.0027 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0599 0.1218
Leishmania major metacaspase, putative 0.0027 0.0043 0.0043
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0389 0.0389
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0136 0.0276
Echinococcus granulosus calpain A 0.0064 0.0389 0.0384
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0114 0.0858 0.0858
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Schistosoma mansoni cathepsin F (C01 family) 0.0377 0.3328 0.3325
Echinococcus multilocularis cathepsin L 0.0086 0.0599 0.0594
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0228 0.0186
Leishmania major cathepsin L-like protease 0.043 0.3831 0.3831
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0274 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.1624 0.162
Brugia malayi fibroinase precursor 0.0086 0.0599 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0086 0.0599 0.1218
Loa Loa (eye worm) hypothetical protein 0.0259 0.2222 0.2217
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0054 0.0297 0.0254
Entamoeba histolytica cysteine proteinase, putative 0.0377 0.3328 0.677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0377 0.3328 0.677
Plasmodium falciparum cysteine proteinase falcipain 1 0.0204 0.1705 0.2723
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0086 0.0599 0.1218
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0054 0.0297 0.0297
Brugia malayi Cathepsin L-like precursor 0.0118 0.0893 0.0853
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0054 0.0297 0.0254
Giardia lamblia Cathepsin B precursor 0.0086 0.0599 0.0969
Echinococcus multilocularis caspase 0.0027 0.0043 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0054 0.0297 0.0603
Plasmodium vivax histone deacetylase, putative 0.0677 0.6148 1
Schistosoma mansoni histone deacetylase 4 5 0.0677 0.6148 0.6146
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0432 0.3848 1
Echinococcus multilocularis geminin 0.0184 0.152 0.1515
Echinococcus multilocularis calpain 5 0.0064 0.0389 0.0384
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0858 0.0818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0054 0.0297 0.0603
Mycobacterium ulcerans hypothetical protein 0.0106 0.0779 0.1733
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1087 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0136 0.0152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0779 0.0774
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0118 0.0893 0.0887
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0027 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0156 0.1249 0.1245
Echinococcus granulosus histone deacetylase 6 0.0731 0.6658 0.6657
Schistosoma mansoni histone deacetylase 1 2 3 0.0278 0.2401 0.2397
Mycobacterium ulcerans beta-lactamase 0.0106 0.0779 0.1733
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0973 0.8929 1
Trypanosoma cruzi oligopeptidase b 0.0432 0.3848 0.3848
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.1775 0.177
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0377 0.3328 0.3324
Trypanosoma brucei antigen, putative 0.0064 0.0389 0.0347
Onchocerca volvulus 0.003 0.0072 0.0028
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0054 0.0297 0.0297
Trypanosoma brucei histone deacetylase 3 0.0677 0.6148 0.6131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.3831 0.3804
Toxoplasma gondii ABC1 family protein 0.0106 0.0779 0.0739
Echinococcus granulosus Dipeptidyl peptidase 9 0.0114 0.0858 0.0853
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0086 0.0599 0.0969
Echinococcus granulosus calpain 5 0.0064 0.0389 0.0384
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0114 0.0858 0.0818
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0139 0.1096 0.1032
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.005 0.0252 0.0247
Schistosoma mansoni calpain (C02 family) 0.0064 0.0389 0.0384
Brugia malayi histone deacetylase 3 (HD3) 0.0546 0.4916 0.4894
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0858 0.0818
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0136 0.0129
Loa Loa (eye worm) hypothetical protein 0.0377 0.3328 0.3324
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0086 0.0599 0.1218
Loa Loa (eye worm) prolyl oligopeptidase 0.0114 0.0858 0.0851
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0086 0.0599 0.1218
Brugia malayi beta-lactamase 0.0106 0.0779 0.0739
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0114 0.0858 0.0853
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0086 0.0599 0.091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Mycobacterium tuberculosis Conserved protein 0.0106 0.0779 0.0732
Echinococcus multilocularis snurportin 1 0.0299 0.26 0.2596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1705 0.3469
Onchocerca volvulus 0.0377 0.3328 0.3299
Leishmania major cathepsin L-like protease 0.0377 0.3328 0.3328
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1249 0.2541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0377 0.3328 0.677
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0086 0.0599 0.091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0072 0.0066
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0377 0.3328 0.5381
Loa Loa (eye worm) hypothetical protein 0.0044 0.0196 0.019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0377 0.3328 0.3324
Schistosoma mansoni cathepsin F (C01 family) 0.0259 0.2222 0.2218
Giardia lamblia Cathepsin L-like protease 0.0086 0.0599 0.0969
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0136 0.0131
Giardia lamblia Cysteine protease 0.0086 0.0599 0.0969
Loa Loa (eye worm) hypothetical protein 0.0086 0.0599 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1375 0.2797
Trypanosoma cruzi cysteine protease, putative 0.0204 0.1705 0.1705
Trypanosoma cruzi metacaspase, putative 0.0027 0.0043 0.0043
Trichomonas vaginalis BRCA1-associated protein, putative 0.0054 0.0297 0.0603
Plasmodium vivax histone deacetylase 2, putative 0.0677 0.6148 1
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1624 0.162
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.0779 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0086 0.0599 0.1218
Trypanosoma cruzi cruzipain precursor, putative 0.043 0.3831 0.3831
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0054 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.0215
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0027 0.0022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0086 0.0599 0.0594
Schistosoma mansoni ap endonuclease 0.0037 0.0136 0.0131
Loa Loa (eye worm) hypothetical protein 0.0106 0.0779 0.0773
Trypanosoma cruzi metacaspase, putative 0.0027 0.0043 0.0043
Giardia lamblia Cathepsin B precursor 0.0294 0.255 0.5049
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0136 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0274 0.0274
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Plasmodium falciparum peptidase, putative 0.0114 0.0858 0.1334
Giardia lamblia Cathepsin L-like protease 0.0086 0.0599 0.0969
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0254 0.0249
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0204 0.1705 0.1705
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.005 0.0007
Entamoeba histolytica cysteine protease, putative 0.0204 0.1705 0.3469
Loa Loa (eye worm) hypothetical protein 0.0174 0.142 0.1414
Trypanosoma cruzi kinesin, putative 0.0045 0.0208 0.0208
Toxoplasma gondii exonuclease III APE 0.0037 0.0136 0.0093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0086 0.0599 0.0594
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0086 0.0599 0.091
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0389 0.0389
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0054 0.0297 0.0254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.0779 0.1733
Echinococcus multilocularis histone deacetylase 6 0.0677 0.6148 0.6146
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0043 0.0038
Leishmania major hypothetical protein, conserved 0.0106 0.0779 0.0779
Brugia malayi Papain family cysteine protease containing protein 0.0377 0.3328 0.3299
Echinococcus multilocularis BRCA1 associated protein 0.0054 0.0297 0.0291
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1249 0.1249
Loa Loa (eye worm) calpain family protein 1 0.0125 0.0962 0.0956
Brugia malayi Bromodomain containing protein 0.0085 0.0587 0.0546
Giardia lamblia Cathepsin B precursor 0.0086 0.0599 0.0969
Trypanosoma brucei calpain-like protein, putative 0.0064 0.0389 0.0347
Loa Loa (eye worm) beta-lactamase 0.0106 0.0779 0.0773
Loa Loa (eye worm) hypothetical protein 0.0118 0.0893 0.0887

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 620 nM In vitro binding affinity was measured as the inhibition of [3H]-Clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes ChEMBL. 3016265
Ki (binding) = 620 nM In vitro binding affinity was measured as the inhibition of [3H]-Clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes ChEMBL. 3016265
Ki (binding) = 820 nM In vitro binding affinity was measured as the inhibition of [3H]-WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranes ChEMBL. 3016265
Ki (binding) = 820 nM In vitro binding affinity was measured as the inhibition of [3H]-WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranes ChEMBL. 3016265
Ki (binding) = 1000 nM In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]-spiroperidol displacement. ChEMBL. 3016265
Ki (binding) = 1000 nM In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]-spiroperidol displacement. ChEMBL. 3016265

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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