Detailed information for compound 402113

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1258.43 | Formula: C62H83N17O12
  • H donors: 17 H acceptors: 14 LogP: -0.49 Rotable bonds: 43
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C[C@@H](C(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)CCCN=C(N)N)C
  • InChi: 1S/C62H83N17O12/c1-33(2)22-50(61(90)91)77-58(87)49(27-40-30-67-32-71-40)74-55(84)46(24-37-17-19-41(81)20-18-37)73-54(83)45(16-11-21-68-62(64)65)72-57(86)48(26-39-29-66-31-70-39)75-56(85)47(25-38-28-69-44-15-10-9-14-42(38)44)76-60(89)52(35(5)80)79-59(88)51(34(3)4)78-53(82)43(63)23-36-12-7-6-8-13-36/h6-10,12-15,17-20,28-35,43,45-52,69,80-81H,11,16,21-27,63H2,1-5H3,(H,66,70)(H,67,71)(H,72,86)(H,73,83)(H,74,84)(H,75,85)(H,76,89)(H,77,87)(H,78,82)(H,79,88)(H,90,91)(H4,64,65,68)/t35-,43+,45+,46+,47+,48+,49+,50+,51+,52+/m1/s1
  • InChiKey: LCZQYCJQZFDPNB-BWLHFABRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens major histocompatibility complex, class I, A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0312 0.048 0.0479
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0341 0.0525 0.3742
Schistosoma mansoni hypothetical protein 0.022 0.0333 0.1567
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0166 0.0778
Schistosoma mansoni tyrosine kinase 0.025 0.038 0.1791
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0036 0.0166
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0849 0.6053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0006 0.0041
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0586 0.0916 0.2645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.0831 0.5923
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0009 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0125 0.0181 0.052
Leishmania major hypothetical protein, unknown function 0.0125 0.0181 0.0491
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Onchocerca volvulus 0.003 0.0029 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Giardia lamblia Kinase, CMGC CK2 0.0145 0.0213 0.22
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0014 0.0039
Echinococcus multilocularis GPCR, family 2 0.0015 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.0901 0.6422
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0031 0.0927
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0003 0.0014
Leishmania major phosphatidylinositol kinase, putative 0.0125 0.0181 0.0491
Echinococcus multilocularis casein kinase ii subunit alpha 0.0145 0.0213 0.0213
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0011 0.007
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0014 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Brugia malayi intracellular kinase 0.0054 0.0068 0.0479
Trypanosoma cruzi dynamin-1-like protein 0.011 0.0156 0.045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0006 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0098 0.0097
Echinococcus granulosus chromobox protein 1 0.0012 0.0001 0.0001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0031 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0011 0.0299
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.218 0.3463 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0166 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0068 0.0183
Leishmania major protein kinase, putative 0.0017 0.0009 0.0022
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0044 0.0124
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0125 0.0181 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.022 0.0333 0.0333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0596 0.0932 0.6644
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0003 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0052 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.002 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0033 0.0032
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0596 0.0932 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0011 0.0076
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0051 0.0062 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0557 0.087 0.6201
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0027 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.0901 0.6422
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0312 0.048 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.0901 0.6422
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.0525 0.2475
Echinococcus granulosus casein kinase ii subunit beta 0.0039 0.0044 0.0044
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0125 0.0181 0.0181
Toxoplasma gondii dynamin gtpase 0.0072 0.0097 0.1077
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Brugia malayi intermediate filament protein 0.0028 0.0027 0.0186
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0095 0.0132 0.0132
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0095
Echinococcus granulosus serine protein kinase ATM 0.0328 0.0505 0.0505
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0003 0.0012
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0341 0.0525 0.2785
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0044 0.0306
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0576 0.0901 0.9667
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0166 0.045
Brugia malayi Cytochrome P450 family protein 0.0031 0.0032 0.0222
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0203 0.0306 0.0305
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0218 0.033 0.3539
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0125 0.0181 0.1283
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0036 0.025
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0016 0.0083
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0663 0.1041 0.7417
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Onchocerca volvulus 0.0013 0.0003 0.0045
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Entamoeba histolytica protein kinase rad3, putative 0.0312 0.048 0.3418
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.0779 0.0779
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0515 0.0805 0.8614
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0164 0.0243 0.2598
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0014 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0012
Schistosoma mansoni fkbp-rapamycin associated protein 0.0312 0.048 0.2261
Loa Loa (eye worm) calcium channel 0.0034 0.0036 0.0186
Trypanosoma brucei polo-like protein kinase 0.0203 0.0306 0.3278
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0014 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.014 0.0205 0.0591
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.019 0.0284 0.2021
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0932 0.6644
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0596 0.0932 0.2691
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0003 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6145
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0364 0.0563 0.6035
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.033 0.2351
Echinococcus multilocularis casein kinase ii subunit beta 0.0039 0.0044 0.0043
Echinococcus granulosus epidermal growth factor receptor 0.047 0.0732 0.0732
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0181 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0181 0.1283
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0036 0.0035
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.089 0.1403 0.405
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.002 0.009
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0146
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0065 0.0085 0.0397
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0203 0.0306 0.0881
Trypanosoma brucei Casein kinase II 0.0145 0.0213 0.2283
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0125 0.0181 0.0849
Trichomonas vaginalis hypothetical protein 0.0012 0.0001 0.0000039043
Schistosoma mansoni hypothetical protein 0.0054 0.0068 0.032
Brugia malayi Protein kinase domain containing protein 0.0142 0.0208 0.1479
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0203 0.0306 0.0834
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6145
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0006 0.0026
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0031 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0092 0.0128 0.0603
Echinococcus granulosus insulin growth factor 1 receptor beta 0.015 0.0221 0.0221
Loa Loa (eye worm) RGS-3 protein 0.002 0.0014 0.0071
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0014 0.0071
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0014 0.0063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0011 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0145 0.1026
Entamoeba histolytica hypothetical protein 0.0012 0.0001 0.0000039043
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0218 0.033 0.2351
Brugia malayi serine/threonine-protein kinase plk-2 0.0203 0.0306 0.2178
Echinococcus granulosus cyclin dependent kinase 19 0.0142 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0596 0.0932 0.2691
Onchocerca volvulus 0.025 0.0381 0.7241
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0596 0.0932 0.0932
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0031 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.051
Toxoplasma gondii dynamin-related protein DRPB 0.011 0.0156 0.1745
Loa Loa (eye worm) hypothetical protein 0.0312 0.048 0.2544
Echinococcus granulosus epidermal growth factor receptor 0.0252 0.0385 0.0385
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0058 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0068 0.0479
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0014 0.0013
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.022 0.0333 0.0332
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0044 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0014 0.0014
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0068 0.0067
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0036 0.0036
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0042 0.0042
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0014 0.0252
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0166 0.9153
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0031 0.1336
Echinococcus granulosus high voltage activated calcium channel beta 0.0092 0.0128 0.0128
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0003 0.0016
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0000039043
Schistosoma mansoni dynamin 0.011 0.0156 0.0735
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.045 0.07 0.4985
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0542 0.3861
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0102 0.0144 0.0677
Schistosoma mansoni protein kinase 0.0145 0.0213 0.1004
Onchocerca volvulus 0.0028 0.0027 0.05
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0027 0.0186
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.0181 0.1283
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0044 0.13
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0033 0.0032
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0125 0.0181 0.1283
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0005 0.0054
Echinococcus granulosus GPCR family 2 0.0015 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0641 0.1006 0.1006
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0014 0.0063
Echinococcus granulosus cpg binding protein 0.0031 0.0032 0.0032
Echinococcus multilocularis Zinc finger, PHD finger 0.0218 0.033 0.033
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0068 0.0621
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0218 0.033 0.033
Giardia lamblia Hypothetical protein 0.0125 0.0181 0.1845
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0011 0.0076
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0341 0.0525 0.0525
Brugia malayi Casein kinase II, alpha chain 0.0145 0.0213 0.1517
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0031 0.0218
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0345 0.0532 0.595
Schistosoma mansoni hypothetical protein 0.0178 0.0266 0.1252
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0532 0.0831 0.8915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0498 0.3548
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0014 0.0095
Echinococcus multilocularis lamin 0.0028 0.0027 0.0026
Echinococcus granulosus dynamin 1 0.0118 0.017 0.017
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0166 0.0875
Brugia malayi Serotonin receptor 0.0495 0.0771 0.5494
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0085 0.0243
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0029 0.0149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0012 0.0001 0.0002
Toxoplasma gondii hypothetical protein 0.0021 0.0014 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0001 0.0000039043
Plasmodium vivax hypothetical protein, conserved 0.0125 0.0181 0.5457
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0019 0.0012 0.0078
Echinococcus multilocularis expressed conserved protein 0.0086 0.012 0.0119
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.0027 0.0027
Brugia malayi Furin-like cysteine rich region family protein 0.047 0.0732 0.5213
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0166 0.0165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0166 0.1176
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0017 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0218 0.033 0.0952
Echinococcus multilocularis epidermal growth factor receptor 0.0252 0.0385 0.0384
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.002 0.002
Echinococcus granulosus expressed conserved protein 0.0086 0.012 0.012
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.002 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0328 0.0505 0.541
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0014 0.0417
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.134 0.2121 1
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0036 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0098 0.0459
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.005
Schistosoma mansoni axis inhibition protein axin 0.002 0.0014 0.0063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0058 0.0412
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.001
Brugia malayi PXA domain containing protein 0.0022 0.0016 0.0112
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0132 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0085 0.06
Echinococcus multilocularis musashi 0.0028 0.0027 0.0026
Entamoeba histolytica hypothetical protein 0.0328 0.0505 0.3595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0025
Entamoeba histolytica dynamin-1-like protein, putative 0.011 0.0156 0.1111
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0016
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0166 0.0476
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0006 0.0027
Echinococcus multilocularis cpg binding protein 0.0031 0.0032 0.0031
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0596 0.0932 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0014 0.0098
Entamoeba histolytica hypothetical protein 0.0073 0.0098 0.0694
Plasmodium vivax dynamin-like protein, putative 0.011 0.0156 0.4725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6145
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0181 0.0955
Brugia malayi Csnk2b protein 0.0039 0.0044 0.0306
Giardia lamblia Kinase, PLK 0.0203 0.0306 0.3206
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0125 0.0181 0.052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0643 0.4584
Echinococcus granulosus lamin dm0 0.0028 0.0027 0.0027
Brugia malayi Dynamin 0.0118 0.017 0.1207
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0014 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.0306
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0218 0.033 0.2351
Brugia malayi Cytochrome P450 family protein 0.0021 0.0014 0.0097
Brugia malayi Protein kinase domain containing protein 0.015 0.0221 0.1573
Loa Loa (eye worm) RecQ helicase 0.0022 0.0017 0.0089
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0006 0.0005
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0068 0.0317
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0027 0.0139
Schistosoma mansoni survival motor neuron protein 0.0102 0.0144 0.0677
Schistosoma mansoni lamin 0.0028 0.0027 0.0124
Brugia malayi SET domain containing protein 0.0014 0.0004 0.0021
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0445 0.0693 0.4934
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0039 0.0044 0.048
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0014 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Schistosoma mansoni netrin receptor unc5 0.0015 0.0006 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0006 0.0035
Loa Loa (eye worm) gastrulation defective protein 1 0.0138 0.0202 0.107
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.014
Brugia malayi Pre-SET motif family protein 0.0032 0.0033 0.0228
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0001 0.000000000185
Entamoeba histolytica protein kinase domain containing protein 0.0145 0.0213 0.1517
Leishmania major phosphatidylinositol 3-kinase, putative 0.0532 0.0831 0.2269
Entamoeba histolytica dynamin-1-like protein, putative 0.0033 0.0034 0.0241
Schistosoma mansoni ap endonuclease 0.0018 0.0011 0.0047
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0063
Trypanosoma cruzi target of rapamycin kinase 3 0.0576 0.0901 0.2602
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0366 0.0567 0.4036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0586 0.0916 0.0916
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0203 0.0306 0.0306
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0044 0.13
Brugia malayi SH2 domain containing protein 0.036 0.0557 0.3968
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0011 0.5
Toxoplasma gondii hypothetical protein 0.0021 0.0014 0.0154
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0125 0.0181 0.0849
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0382 0.2022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0012 0.0001 0.0002
Schistosoma mansoni kinase 0.0105 0.0149 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Loa Loa (eye worm) TK/EGFR protein kinase 0.047 0.0732 0.388
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Leishmania major phosphatidylinositol kinase related protein, putative 0.014 0.0205 0.0559
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0306 0.1441
Brugia malayi Protein kinase domain containing protein 0.0341 0.0525 0.3742
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0366 0.0567 0.4036
Onchocerca volvulus 0.0052 0.0065 0.1233
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0014 0.0072
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0596 0.0932 0.2545
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0586 0.0916 0.0916
Echinococcus granulosus axis inhibition protein axin 0.002 0.0014 0.0014
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0005 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0011 0.0011
Onchocerca volvulus Serine\/threonine kinase homolog 0.0203 0.0306 0.5821
Giardia lamblia Dynamin 0.011 0.0156 0.1583
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0095 0.0132 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0166 0.1176
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0085 0.0243
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Brugia malayi hypothetical protein 0.0499 0.0779 0.555
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.002 0.0019
Brugia malayi hypothetical protein 0.0173 0.0258 0.1834
Entamoeba histolytica hypothetical protein 0.0742 0.1167 0.8316
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0014 0.0014
Onchocerca volvulus 0.0044 0.0052 0.0977
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0025
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.052
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0033 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0027 0.0189
Schistosoma mansoni vav2 0.0014 0.0003 0.0014
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.089 0.1403 0.405
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0181 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0014 0.0013
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0341 0.0525 1
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0382 0.2717
Brugia malayi phosphofructokinase 0.0115 0.0166 0.1176
Loa Loa (eye worm) hypothetical protein 0.0345 0.0532 0.2819
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0218 0.033 1
Schistosoma mansoni serine/threonine-protein kinase 0.0012 0.0001 0.0001
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0021 0.0014 0.0229
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0166 0.1176
Echinococcus granulosus protein kinase shaggy 0.0054 0.0068 0.0068
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0218 0.033 0.2351
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0663 0.1041 0.7417
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0173 0.0258 0.1365
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0036 0.0035
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0146
Leishmania major GTP-binding protein, putative 0.011 0.0156 0.0426
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0011 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0058 0.0412
Loa Loa (eye worm) phosphatidylinositol 3 0.0242 0.0368 0.1947
Schistosoma mansoni tyrosine kinase 0.047 0.0732 0.3448
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0177
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0332 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.0505 0.3595
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.089 0.1403 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.5457
Echinococcus multilocularis 0.0125 0.0181 0.018
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0014 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0125 0.0181 0.5457
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0166 0.1176
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0013 0.0374
Schistosoma mansoni hypothetical protein 0.0073 0.0098 0.0459
Echinococcus multilocularis dynamin 1 0.0118 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.022 0.0333 0.1763
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.015 0.0221 0.0221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.0181 0.1283
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0068 0.0194
Entamoeba histolytica hypothetical protein 0.0125 0.0181 0.1283
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0006 0.0005
Echinococcus granulosus death domain containing protein 0.0015 0.0006 0.0006
Toxoplasma gondii target of rapamycin (TOR), putative 0.0571 0.0893 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0312 0.048 0.1384
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.033 0.1555
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0027 0.0189
Schistosoma mansoni tyrosine kinase 0.0252 0.0385 0.1811
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0139
Loa Loa (eye worm) hypothetical protein 0.0125 0.0181 0.0955
Leishmania major hypothetical protein, conserved 0.2305 0.3662 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0125 0.0181 0.5457
Plasmodium vivax SET domain protein, putative 0.0032 0.0033 0.0971
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0144 0.1023
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0031 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.0831 0.5923
Brugia malayi hypothetical protein 0.002 0.0014 0.0095
Entamoeba histolytica serine/threonine protein kinase, putative 0.0203 0.0306 0.2178
Leishmania major phosphatidylinositol 3-kinase, putative 0.0218 0.033 0.0901
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0085 0.0085
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0218 0.033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0557 0.087 0.6201
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0011 0.007
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0012 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0389 0.0602 0.4287
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.1931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0152
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0001 0.000000000068323
Entamoeba histolytica hypothetical protein 0.0012 0.0001 0.0000039043
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0366 0.0567 0.4036
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0063
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0029
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.001 0.0044
Entamoeba histolytica hypothetical protein 0.0014 0.0003 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0145 0.1026
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0031 0.0225
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0036 0.0035
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0166 1
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0068 0.0067
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0003 0.0006
Onchocerca volvulus 0.0125 0.0181 0.343
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0017 0.0119
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0273 0.0417 0.4407
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.134 0.2121 0.2121
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0085 0.0903
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0042 0.0298
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0218 0.033 0.175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0328 0.0505 0.3595
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0005 0.0023
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0125 0.0181 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0044 0.13
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.001
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0014 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0073 0.081
Leishmania major protein kinase, putative 0.0017 0.0009 0.0022
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.011 0.0156 0.1111
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0017 0.0017
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0068 0.0356
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.0532 0.3788
Echinococcus multilocularis Ankyrin 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0641 0.1006 0.5333
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0098 0.0098
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0312 0.048 0.3418
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0063
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0012 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.1192 0.1885 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0341 0.0525 0.2785
Entamoeba histolytica hypothetical protein 0.0012 0.0001 0.0000039043
Entamoeba histolytica protein kinase, putative 0.0054 0.0068 0.0479
Entamoeba histolytica hypothetical protein 0.0073 0.0098 0.0694
Plasmodium vivax unspecified product 0.0145 0.0213 0.6451
Schistosoma mansoni cpg binding protein 0.003 0.0029 0.0133
Schistosoma mansoni hypothetical protein 0.0086 0.012 0.0561
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.002 0.0101
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0203 0.0306 0.1621
Onchocerca volvulus 0.0102 0.0144 0.2737
Loa Loa (eye worm) hypothetical protein 0.0297 0.0456 0.2415
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0166 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0068 0.0479
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.0027 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Schistosoma mansoni tyrosine kinase 0.0252 0.0385 0.1811
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0036 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.003 0.003
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0125 0.0181 0.1283
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0009 0.0023
Schistosoma mansoni tyrosine kinase 0.025 0.038 0.1791
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0014 0.0072
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0009 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0001 0.000000000185
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Mycobacterium leprae conserved hypothetical protein 0.0125 0.0181 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0106 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0003 0.0007
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0145 0.0213 0.1129
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Trypanosoma cruzi casein kinase II, putative 0.0145 0.0213 0.0614
Schistosoma mansoni axis inhibition protein axin 0.002 0.0014 0.0063
Giardia lamblia Casein kinase II beta chain 0.0039 0.0044 0.0358
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6275 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.5457
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.0306 0.0882
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Trypanosoma brucei dynamin-1-like protein 0.011 0.0156 0.1672
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0011 0.0027
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0014 0.0154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.0181 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.002 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0542 0.3861
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0065 0.0085 0.0084
Loa Loa (eye worm) Csnk2b protein 0.0039 0.0044 0.0227
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0766 0.1204 0.858
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0003 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Schistosoma mansoni single-minded 0.0052 0.0064 0.0299
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0596 0.0932 0.6644
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0095
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0014 0.0245
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0125 0.0181 0.2015
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0065 0.0085 0.0243
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0003 0.0016
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.019 0.0284 0.1504
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0016
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0166 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0208 0.0978
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0641 0.1006 0.1005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.033 0.3693
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0218 0.033 0.2351
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0003 0.0016
Echinococcus multilocularis tumor protein p63 0.0358 0.0554 0.0553
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0036 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0034 0.0238
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0031 0.0927
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0039 0.0044 0.046
Brugia malayi PAS domain containing protein 0.0052 0.0064 0.0451
Loa Loa (eye worm) hypothetical protein 0.0203 0.0306 0.1619
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0085 0.06
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0036 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Echinococcus multilocularis dynamin 0.011 0.0156 0.0156
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Brugia malayi Cytochrome P450 family protein 0.0021 0.0014 0.0097
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0006 0.0028
Onchocerca volvulus 0.0107 0.0152 0.2878
Echinococcus multilocularis epidermal growth factor receptor 0.047 0.0732 0.0731
Echinococcus multilocularis lamin dm0 0.0028 0.0027 0.0026
Brugia malayi Pre-SET motif family protein 0.022 0.0332 0.2363
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0011 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0218 0.033 0.0952
Brugia malayi PXA domain containing protein 0.0022 0.0016 0.0112
Echinococcus granulosus Chromobox protein 3 0.0012 0.0001 0.0001
Toxoplasma gondii dynamin-related protein DRPA 0.011 0.0156 0.1745
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Brugia malayi hypoxia-induced factor 1 0.016 0.0236 0.1681
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0063
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0166 0.0875
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0044 0.0306
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0028
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0014 0.0095
Loa Loa (eye worm) hypothetical protein 0.036 0.0557 0.2953
Echinococcus granulosus bloom syndrome protein 0.0022 0.0017 0.0017
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0065 0.0085 0.0903
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0366 0.0567 0.4036
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0001 0.000000000043497
Leishmania major cytochrome p450-like protein 0.0021 0.0014 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.089 0.1403 1
Trypanosoma brucei dynamin-1-like protein 0.011 0.0156 0.1672
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0014 0.0013
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0009 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0596 0.0932 0.4394
Schistosoma mansoni casein kinase II beta subunit 0.0039 0.0044 0.0203
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0036 0.0035
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0068 0.0356
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0166 0.177
Toxoplasma gondii ck2 beta subunit 0.0039 0.0044 0.048
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0181 0.0955
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0218 0.033 0.0901
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0032 0.0165
Toxoplasma gondii CMGC kinase, CK2 family 0.0145 0.0213 0.2383
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0065 0.0085 0.06
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.0027 0.0189
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0166 0.0778
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0000039043
Schistosoma mansoni tyrosine kinase 0.015 0.0221 0.1041
Entamoeba histolytica hypothetical protein 0.0125 0.0181 0.1283
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0068 0.2037
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0125 0.0181 0.1931
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.002 0.0101
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0027 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6144
Brugia malayi CHD4 protein 0.0014 0.0003 0.0019
Brugia malayi hypothetical protein 0.0073 0.0098 0.0694
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0003 0.0002
Brugia malayi Dynamin central region family protein 0.011 0.0156 0.1111
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0016
Schistosoma mansoni tyrosine kinase 0.015 0.0221 0.1041
Schistosoma mansoni chromobox protein 0.0012 0.0001 0.0001
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0006 0.0101
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.0152
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0025
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.0027 0.0189
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0068 0.2037
Echinococcus granulosus axis inhibition protein axin 0.002 0.0014 0.0014
Trichomonas vaginalis set domain proteins, putative 0.025 0.038 0.2708
Loa Loa (eye worm) hypothetical protein 0.0499 0.0779 0.4131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0033 0.0359
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0125 0.0181 0.2015
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0014 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0281 0.1998
Giardia lamblia Phosphatidylinositol 4-kinase 0.0125 0.0181 0.1845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0586 0.0916 0.653
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0218 0.033 0.2351
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0586 0.0916 0.4319
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Loa Loa (eye worm) hypothetical protein 0.0107 0.0152 0.0801
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Plasmodium falciparum calcium-dependent protein kinase 7 0.0012 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0366 0.0567 0.4036
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0031 0.0927
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0011 0.0106
Loa Loa (eye worm) phosphatidylinositol 3 0.0596 0.0932 0.4945
Toxoplasma gondii exonuclease III APE 0.0018 0.0011 0.011
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0596 0.0932 0.6644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0932 0.6644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.0581 0.4139
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0014 0.0147
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0544 0.0849 0.2318
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0014 0.0095
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0001 0.0001
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0252 0.0385 0.0385
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0644 0.101 0.7194
Loa Loa (eye worm) DRP-1 protein 0.011 0.0156 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Schistosoma mansoni chromobox protein 0.0012 0.0001 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0006
Loa Loa (eye worm) TK/INSR protein kinase 0.015 0.0221 0.1171
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0014 0.0013
Trichomonas vaginalis dynamin, putative 0.011 0.0156 0.1111
Echinococcus granulosus intermediate filament protein 0.0028 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.048 0.3418
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0742 0.1167 0.8316
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0052 0.0365
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0068 0.0752
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0324 0.0498 0.3548
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0333 0.2369
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0014 0.0252
Brugia malayi Dynamin 0.0118 0.017 0.1207
Echinococcus granulosus tumor protein p63 0.0358 0.0554 0.0554
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0014 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0011 0.0299
Schistosoma mansoni tyrosine kinase 0.025 0.038 0.1791
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0003 0.0016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0125 0.0181 0.0849
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0125 0.0181 0.5457
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0014 0.0095
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0544 0.0849 0.911
Brugia malayi hypothetical protein 0.0107 0.0152 0.1078
Loa Loa (eye worm) hypothetical protein 0.0118 0.017 0.0898
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0014 0.0417
Schistosoma mansoni hypothetical protein 0.0125 0.0181 0.0849
Echinococcus multilocularis dynamin 1 protein 0.011 0.0156 0.0156
Onchocerca volvulus 0.0054 0.0068 0.1282
Echinococcus multilocularis geminin 0.0178 0.0266 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0181 0.1283
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0542 0.3861
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0031 0.0927
Echinococcus multilocularis 0.0145 0.0214 0.0213
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0366 0.0567 0.1635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6144
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.0831 0.5923
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.0901 0.6422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.0831 0.5923
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0031 0.0218
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0006 0.0154
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0031 0.0342
Trichomonas vaginalis mgm1, putative 0.011 0.0156 0.1111
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.134 0.2121 0.2121
Entamoeba histolytica hypothetical protein 0.0125 0.0181 0.1283
Brugia malayi M-phase phosphoprotein, mpp8 0.0107 0.0152 0.1076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0000039043
Onchocerca volvulus 0.0125 0.0181 0.343
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0218 0.033 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0862 0.6145
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0017 0.0119
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0064 0.0299
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0044 0.0819
Onchocerca volvulus 0.0107 0.0152 0.2878
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0125 0.0181 0.018
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0341 0.0525 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Echinococcus granulosus Chromo domain 0.0012 0.0001 0.0001
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0242 0.0368 0.106
Echinococcus granulosus casein kinase ii subunit alpha 0.0145 0.0213 0.0213
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0068 0.0068
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0014 0.0013
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0145 0.0213 0.6451
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.052
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0044 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0011 0.007
Entamoeba histolytica hypothetical protein 0.0073 0.0098 0.0694
Echinococcus multilocularis insulin receptor 0.015 0.0221 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.055 0.3917
Echinococcus granulosus insulin receptor 0.015 0.0221 0.0221
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0036 0.0036
Echinococcus granulosus single minded 2 0.0038 0.0042 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0596 0.0932 0.0932
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.0236 0.1251
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0218 0.033 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0011 0.0076
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0328 0.0505 0.2378
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0039 0.0044 0.0117
Echinococcus granulosus dynamin 0.011 0.0156 0.0156
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0166 0.1176
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0417 0.0647 0.305
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0006 0.0025
Plasmodium vivax dynamin protein, putative 0.011 0.0156 0.4725
Giardia lamblia GTOR 0.0596 0.0932 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0006 0.0027
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0014 0.0095
Entamoeba histolytica casein kinase, putative 0.0145 0.0213 0.1517
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0084 0.0392
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.033 0.3693
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0306 0.2178
Leishmania major casein kinase II, putative 0.0145 0.0213 0.0581
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0125 0.0181 0.2015
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.1354 0.1354
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0166 0.9116
Echinococcus granulosus Ankyrin 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.00000000003237
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0366 0.0567 0.6074
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0001 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.0779 0.0778
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0000039043
Echinococcus granulosus chromobox protein 2 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0134
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0044 0.0819
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0014 0.0648
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0596 0.0932 0.2545
Echinococcus multilocularis cyclin dependent kinase 19 0.0142 0.0208 0.0207
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0142 0.0208 0.11
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0158
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0095
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0218 0.033 0.033
Schistosoma mansoni serine/threonine-protein kinase 0.0012 0.0001 0.0001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0044 0.0306
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Loa Loa (eye worm) hypothetical protein 0.0107 0.0152 0.0802
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0181 0.0955
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0011 0.007
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0014 0.0014
Plasmodium falciparum dynamin-like protein 0.011 0.0156 0.4725
Schistosoma mansoni hypothetical protein 0.0178 0.0266 0.1252
Brugia malayi 6-phosphofructokinase 0.0115 0.0166 0.1176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0000039043
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0052 0.0365
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.089 0.1403 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0006 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0072 0.051
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0065 0.0085 0.06
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0213 0.1517
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0001 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0005
Brugia malayi Death domain containing protein 0.0015 0.0006 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0068 0.0479
Echinococcus multilocularis expressed protein 0.0396 0.0613 0.0613
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0166 0.1176
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0044 0.13
Loa Loa (eye worm) phosphatidylinositol 3 0.0544 0.0849 0.4504
Onchocerca volvulus 0.0028 0.0027 0.05
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0065 0.0305
Echinococcus multilocularis high voltage activated calcium channel beta 0.0092 0.0128 0.0128
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0125 0.0181 0.0181
Plasmodium falciparum casein kinase 2, alpha subunit 0.0145 0.0213 0.6451
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0001 0.000000000043497
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0036 0.0166
Schistosoma mansoni dynamin 0.0118 0.017 0.0799
Brugia malayi Uncoordinated protein 44 0.0015 0.0006 0.0037
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0586 0.0916 0.2645
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0071
Onchocerca volvulus 0.0038 0.0042 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.0932 0.6644
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0063
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0328 0.0505 0.1456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.0901 0.6422
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0006 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0068 0.0479
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0063
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0003 0.0007
Echinococcus multilocularis serine protein kinase ATM 0.0328 0.0505 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.0893 0.6366
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0031 0.0342
Echinococcus granulosus serine/threonine protein kinase 0.0012 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.089 0.1403 1
Echinococcus granulosus expressed protein 0.0396 0.0613 0.0613
Schistosoma mansoni chromobox protein 0.0012 0.0001 0.0001
Echinococcus granulosus chromobox protein 1 0.0012 0.0001 0.0001
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0068 0.0621
Entamoeba histolytica hypothetical protein 0.0073 0.0098 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0095
Brugia malayi CXXC zinc finger family protein 0.003 0.0029 0.0201
Brugia malayi 6-phosphofructokinase 0.0115 0.0166 0.1176
Plasmodium falciparum dynamin-like protein 0.011 0.0156 0.4725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0212 0.1504
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0006
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0576 0.0901 0.246
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0006 0.0041
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0021 0.0014 0.0229
Trypanosoma brucei protein kinase, putative 0.0054 0.0068 0.0721
Schistosoma mansoni chromobox protein 0.0012 0.0001 0.0001
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0014 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Toxoplasma gondii FATC domain-containing protein 0.0328 0.0505 0.5647
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0014 0.0063
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.0128 0.0128
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0052 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0011 0.0028
Loa Loa (eye worm) phosphatidylinositol kinase 0.0125 0.0181 0.0955
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0166 0.1176
Entamoeba histolytica dynamin-like protein 0.011 0.0156 0.1111
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.0128 0.0128
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0042 0.2061
Leishmania major phosphatidylinositol 4-kinase, putative 0.0125 0.0181 0.0491
Brugia malayi FAT domain containing protein 0.022 0.0333 0.2369
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.089 0.1403 1
Toxoplasma gondii hypothetical protein 0.0057 0.0072 0.08
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0006 0.0037
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.0306 0.0882
Schistosoma mansoni intermediate filament proteins 0.0028 0.0027 0.0124
Echinococcus granulosus dynamin 1 protein 0.011 0.0156 0.0156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0006 0.0037
Echinococcus granulosus lamin 0.0028 0.0027 0.0027
Echinococcus granulosus geminin 0.0178 0.0266 0.0266
Plasmodium vivax hypothetical protein 0.0125 0.0181 0.5457
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0132 0.0622
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0065 0.0085 0.06
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0036 0.0035
Schistosoma mansoni ap endonuclease 0.0018 0.0011 0.0047
Brugia malayi hypothetical protein 0.002 0.0014 0.0095
Schistosoma mansoni lamin 0.0028 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0052 0.0065 0.0343
Schistosoma mansoni dynamin 0.0118 0.017 0.0799
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0281 0.1998

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.025 MHC class I HLA-A*0201 binding affinity assayed by based inhibition of binding of a radiolabeled standard peptide (FLPSDYFPSV) ChEMBL. 11606121
Log IC50 (binding) = 6.025 MHC class I HLA-A*0201 binding affinity assayed by based inhibition of binding of a radiolabeled standard peptide (FLPSDYFPSV) ChEMBL. 11606121

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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